Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| the association of congenital hypothyroidism and congenital gastrointestinal anomalies in down's syndrome infants. | to study the prevalence of congenital hypothyroidism in infants with down's syndrome and to verify whether there is an association with other congenital defects. | 1998 | 9642639 |
| [a case of primary squamous cell lung cancer invading the wall of the distal aortic arch and the left subclavian artery: successful surgical management using ecc with selective cerebral perfusion]. | a 37-year-old male was referred to our hospital with symptoms suggesting pneumonia. the preoperative diagnosis was primary lung cancer of the left upper lobe invading the distal aortic arch (daa) (t4, stage iiib). complete resection was performed with associated resection of the pneumonectomy, daa, and left subclavian artery. dacron graft replacement was performed using ecc with selective cerebral perfusion. histological examination revealed squamous cell carcinoma, n1 and negative surgical marg ... | 1998 | 9642697 |
| a randomised comparison of 'casodex' (bicalutamide) 150 mg monotherapy versus castration in the treatment of metastatic and locally advanced prostate cancer. | to evaluate the efficacy and tolerability of 'casodex' monotherapy (150 mg daily) for metastatic and locally advanced prostate cancer. | 1998 | 9643663 |
| uv-dna damage in mouse and human cells induces the expression of tumor necrosis factor alpha. | ultraviolet light induces the expression of tumor necrosis factor alpha (tnf alpha) in many mammalian cells. we have examined the signal for this induction in a human dna repair-deficient cell line carrying a transgene composed of the murine tnf regulatory sequences fused to the chloramphenicol acetyltransferase (cat) structural gene. when compared by fluence, uvc was a more efficient inducer of cat than was uvb, but they were equivalent inducers when compared by the frequency of cyclobutyl pyri ... | 1998 | 9644008 |
| [predictive significance of reflex otalgia in local radical radiotherapy of oropharyngeal carcinomas]. | patients with carcinomas of the upper aero-digestive tract often suffer from ear pain as a tumor associated syndrome. this prospective study examines the predictive and prognostic value of this symptom. | 1998 | 9645211 |
| characterization of gene-specific dna repair by primary cultures of rat hepatocytes. | at present, almost all the information on gene-specific dna repair in mammals comes from studies with transformed cell lines and proliferating primary cells obtained from rodents and humans. in the present study, we measured the repair of specific dna regions in primary cultures of nondividing rat hepatocytes (parenchymal cells). dna damage was induced by irradiating the primary cultures of hepatocytes with ultraviolet (uv) light, and the presence of cyclobutane pyrimidine dimers (cpds) was meas ... | 1998 | 9648918 |
| multigenerational study of the effects of consumption of pcb-contaminated carp from saginaw bay, lake huron, on mink. 1. effects on mink reproduction, kit growth and survival, and selected biological parameters. | this study was conducted to determine the multigenerational effects of consumption of pcb-contaminated carp (cyprinus carpio) from saginaw bay (lake huron) on mink (mustela vison) reproduction and health and to examine selected biomarkers as potential indicators of polyhalogenated hydrocarbon toxicity in mink. the mink were fed diets formulated to provide 0 (control), 0.25, 0.5, or 1.0 ppm polychlorinated biphenyls (pcbs) through substitution of saginaw bay carp for ocean fish in the diets. to d ... | 1998 | 9650571 |
| safety of beating heart anastomosis during video-assisted coronary surgery attested by cardiac troponin i. | our objective was to evaluate the safety of coronary anastomosis on the beating heart by measuring the release of cardiac troponin i during minimally invasive coronary artery bypass grafting (micabg). cardiac troponin i (ctni) is a reliable marker of cardiac ischemia during heart operations under cardiopulmonary bypass (cpb). ten patients (8 males and 2 females, aged 41-63) underwent micabg with single vessel bypass grafting for left anterior descending coronary artery (lad) stenosis (n = 7) or ... | 1998 | 9650674 |
| prostate-thyroid axis: stimulatory effects of ventral prostate secretions on thyroid function. | endocrine cells of the prostate secrete thyrotropin (tsh)-releasing hormone (trh), trh- and tsh-like peptides, and growth factors. propylthiouracil- and methimazole-induced hypothyroidism increased prostatic levels of trh in rats as in hypothalamus, whereas thyroxine (t4) replacement decreased trh. from these reports, we inferred the existence of a prostate-thyroid axis. | 1998 | 9650910 |
| relation between bone mineral content and clinical, hormonal and biochemical parameters in postmenopausal women. | we studied factors related to bone mass after a natural or surgical menopause in 73 healthy women attending the menopause clinic of a university hospital. in the natural menopause group we found inverse correlations between bone mineral density (bmd) vs. menopausal duration; bmd vs. body mass index (bmi) and bmi vs. inorganic phosphate (pi), borderline correlations between weight vs. thyroxin (t4) and weight vs. luteinising hormone (lh) and a positive correlation between androstenedione (d4a) vs ... | 1998 | 9651656 |
| disposition of 2-methylimidazole in rats. | 2-methylimidazole (2-mi), widely used as a chemical intermediate, is also present in cigarette smoke and may form in food and forage as a result of ammoniation of simple sugars. 2-mi has been shown to be neurotoxic in several animal species and to alter serum levels of t3, t4, and thyroid-stimulating hormone (tsh) in the rat, apparently leading to hyperplasia of thyroid follicular cells. in order to better characterize 2-mi-induced toxicity, the disposition of [2-(14)c]-2-mi has been investigate ... | 1998 | 9652548 |
| induction chemotherapy and radiotherapy in loco-regionally advanced epidermoid carcinoma of the anal canal. | to evaluate the efficacy of induction chemotherapy in combination with radiotherapy for treatment of loco-regionally advanced epidermoid anal carcinoma. | 1998 | 9652850 |
| a hypopituitary patient who attained tall stature without growth hormone. | we describe an unusual patient with hypopituitarism who attained tall stature even without growth hormone (gh). a 37-year-old man was devoid of secondary sexual characteristics, but manifested tall stature with a eunuchoidal feature. serum levels of gh, insulin-like growth factor-i, gonadotropins and testosterone were all below normal. gh secretion was not enhanced by any provocative stimulus. adrenocorticotropic hormone increased after administration of corticotropin releasing hormone, but not ... | 1998 | 9652904 |
| localization and characterization of the dimerization domain of holliday structure resolving endonuclease vii of phage t4. | endonuclease vii (endo vii) is a holliday structure resolving enzyme of bacteriophage t4. its nucleolytic activity depends on subactivities, which in order of execution are: (i) dimerization, (ii) binding to dna, (iii) and cleavage of dna. in an effort to assign these subfunctions to the primary sequence of the protein, a series of spontaneous point mutations deficient in dna cleavage was isolated. some of these mutations affected the dimerization of endo vii. compared with wild-type protein, wh ... | 1998 | 9653032 |
| effects of bulky polycyclic aromatic hydrocarbon adducts on dna replication by exonuclease-deficient t7 and t4 dna polymerases. | in vitro dna replication by exonuclease-deficient t7 dna polymerase (sequenase) and an exonuclease deficient t4 dna polymerase was examined on a 244-nucleotide dna template treated with three electrophilic polycyclic aromatic hydrocarbon (pah) metabolites: racemic trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (bapde), trans-2,3-dihydroxy-anti-1,10b-epoxy-10b,1,2,3-tetrahydrofluoranthene (fade), or 3,4-epoxy-3,4-dihydrocyclopenta[cd]pyrene (cppe). the dna replication termi ... | 1998 | 9655247 |
| effect of ergotamine and ergonovine on plasma concentrations of thyroid hormones and cortisol in cattle. | plasma samples from two experiments were processed to determine whether ergot alkaloids associated with endophyte-infected tall fescue altered peripheral thyroxine (t4), triiodothyronine (t3), or cortisol concentrations in cattle. in exp. 1, seven angus steers (294 kg) received i.v. bolus injections of saline (sal), ergonovine maleate (7 mg; em), or ergotamine tartrate (7 mg; et) at weekly intervals, and they received all treatments during the study. blood was sampled every 15 min for 5 h, and t ... | 1998 | 9655585 |
| [early treated congenital hypothyroidism. evaluation of school learning]. | the aim of this paper was to evaluate school learning in early treated ch children in order to investigate whether and how this pathology influences school performance. | 1998 | 9658792 |
| mapping of functional sites on the primary structure of the tail lysozyme of bacteriophage t4 by mutational analysis. | tail lysozyme of bacteriophage t4, product of gene 5 (gp5), functions upon infection by locally digging a hole in the peptidoglycan layer, so that the tail tube, through which the phage dna is injected, can penetrate to the inner membrane. it has been inferred from dna sequence and expression of the tail lysozyme on a plasmid in escherichia coli that the tail lysozyme is synthesized as a precursor of 62 k and is later cleaved to form a mature tail lysozyme of 42 k. furthermore, gp5 has a region ... | 1998 | 9659385 |
| extended operation for t4 lung carcinoma. | the extended surgery for t4 lung carcinoma was reviewed. from literature in the last decade, the 5-year survival rate has been under 10% worldwide. however a more favorable prognosis will be expected nowadays because of the progress of perioperative intensive care and appearance of effective anticancerous agents for induction chemotherapy. we compared the results of surgery for t4 lung carcinoma from 1978 to 1989, to those from 1992 to 1997. the 3 and 5-year survivals in the former period were 6 ... | 1998 | 9660907 |
| randomized trial of pamidronate in patients with thyroid cancer: bone density is not reduced by suppressive doses of thyroxine, but is increased by cyclic intravenous pamidronate. | patients taking suppressive doses of t4 are thought to have accelerated bone loss and increased risk of osteoporosis. we therefore randomize 55 patients taking suppressive doses of t4 to treatment with pamidronate (apd) 30 mg i.v. every 3 months for 2 yr (apd/t4), or placebo (placebo/t4). patients had measurements of bone mineral density (bmd) of the spine, hip, radius, and total body every 6 months for 2 yr. there was no significant bone loss at any site in the placebo/t4 group. ninety five per ... | 1998 | 9661603 |
| changes in the degree of sialylation of carbohydrate chains modify the biological properties of circulating thyrotropin isoforms in various physiological and pathological states. | variation in asparagine-linked carbohydrate chains have a major impact on tsh biological properties. in particular, highly sialylated tsh is characterized by impaired intrinsic bioactivity and prolonged half-life. the aim of the present study was to investigate the changes in the degree of sialylation of circulating tsh isoforms that may occur in several physiological and clinical situations. bioactivity and terminal sugar residues of immunopurified tsh were studied in 26 normal adults (day- and ... | 1998 | 9661632 |
| effect of propylthiouracil-induced hypothyroidism on the onset of skeletal muscle necrosis in dystrophin-deficient mdx mice. | 1. duchenne and becker muscular dystrophies are x-linked disorders caused by defects in muscle dystrophin. the mdx mouse is an animal model for duchenne muscular dystrophy which has a point mutation in the dystrophin gene, resulting in little (<3%) or no expression of dystrophin in muscle. mdx mice show a characteristic pattern of muscle necrosis and regeneration. muscles are normal until the third postnatal week when widespread necrosis commences. this is followed by muscle regeneration, with t ... | 1998 | 9662489 |
| water enema computed tomography (we-ct) in the local staging of low colorectal neoplasms: comparison with transrectal ultrasound. | to determine the accuracy of computed tomography performed with a water enema application (we-ct) in the local staging of low colorectal neoplasms and to compare the results with those of transrectal ultrasonography (trus). | 1998 | 9663271 |
| results of accelerated radiotherapy for supraglottic carcinoma: a massachusetts general hospital and massachusetts eye and ear infirmary experience. | carcinoma of the supraglottic larynx is a relatively common malignancy treated with either surgery, radiotherapy, or a combined approach. | 1998 | 9663664 |
| mismatch negativity to speech stimuli in 8-month-old infants and adults. | the mismatch negativity (mmn) was measured in 15 normal awake 8-month-old infants and 10 adults to the speech consonants /da/ and /ta/. erps were analyzed at 11 electrodes (fz, cz, pz, c3, c4, t3, t4, t5, t6, p3, p4). four-hundred trials were presented: the /da/ standards with 80% probability and the /ta/ deviants with 20% probability. the isi was 600 ms. an mmn was observed for both adults and infants but with different scalp distributions. a clear infant mmn was observed only at c3 and t3 elec ... | 1998 | 9664230 |
| nodal disease in purely glottic carcinoma: is elective neck treatment worthwhile? | although there is a generalized understanding of the relatively low overall incidence of nodal disease from purely glottic carcinoma, the exact role for elective neck treatment in the management of this disease remains controversial. the purpose of this study was to identify the incidence of occult nodal disease (including paratracheal) in patients who have glottic carcinoma without significant extraglottic extension and to identify which patients are at risk for this. a retrospective chart revi ... | 1998 | 9665247 |
| surgery versus radiation therapy as single-modality treatment of tonsillar fossa carcinoma: the roswell park cancer institute experience (1971-1991). | to compare the efficacy and treatment outcomes in patients with tonsillar fossa cancer using surgery or radiation as a single modality therapy. | 1998 | 9665249 |
| exonuclease-polymerase active site partitioning of primer-template dna strands and equilibrium mg2+ binding properties of bacteriophage t4 dna polymerase. | the binding of bacteriophage t4 dna polymerase (t4 pol) to primer-template dna with 2-aminopurine (2ap) located at the primer terminus results in the formation of a hyperfluorescent 2ap state. changes in this hyperfluorescent state were utilized to investigate the fractional concentration of primer-templates bound at the exonuclease and statically quenched polymerase sites. in the absence of mg2+, a hydrophobic exonuclease site dominates over the polymerase site for possession of the primer term ... | 1998 | 9665720 |
| stopped-flow fluorescence study of precatalytic primer strand base-unstacking transitions in the exonuclease cleft of bacteriophage t4 dna polymerase. | dna polymerases are complex enzymes which bind primer-template dna and subsequently either extend or excise the terminal nucleotide on the primer strand. in this study, a stopped-flow fluorescence anisotropy binding assay is combined with real-time measurements of a fluorescent adenine analogue (2-aminopurine) located at the 3'-primer terminus. using this combined approach, the exact time course associated with protein binding, primer terminus unstacking, and base excision by the 3' --> 5' exonu ... | 1998 | 9665721 |
| [cervical epidural hematoma caused by cervical twisting after epidural anesthesia: a case report]. | a case of cervical epidural hematoma caused by cervical twisting after epidural anesthesia was reported. a 41-year-old man who had had anterior fusion of c5 - 7 using a plate due to cervical spondylosis fifteen months before admission, had undergone epidural anesthesia through the c7/t1 interspace without difficulty for shoulder pain in a pain clinic. two hours after injection, he complained of severe pain in his neck and both shoulders just after cervical twisting as was his custom. within minu ... | 1998 | 9666497 |
| prognostic factors in muscle-invasive bladder cancer treated with radiotherapy: an immunohistochemical study. | to determine the prognostic role of p53, ki-67 and p21 for patients with muscle-invasive bladder cancer treated with curative intent by radiotherapy. | 1998 | 9666772 |
| local immune response after intravesical interferon gamma in superficial bladder cancer. | to investigate the lymphocyte subpopulations (t4, t8 and macrophages) and major histocompatibility (mhc) ii antigens in patients with superficial bladder cancer before and after intravesical instillations of recombinant interferon-gamma (ifn-gamma). | 1998 | 9666774 |
| optimizing data acquisition and analysis of morphometric x-ray absorptiometry. | morphometric x-ray absorptiometry (mxa) uses dual-energy x-ray absorptiometry (dxa) scanners to perform vertebral morphometric measurements of the vertebrae. in this study we evaluated the four available mxa scan modes--single-energy (se) and dual-energy fast (f), array (a) and high definition (hd)--on a commercial bone densitometer (hologic qdr-4500a). sixty postmenopausal women (mean age 59 years, range 40-73 years) were recruited and split into two groups matched for body mass index (bmi, kg/ ... | 1998 | 9666943 |
| [hypotension in acyclovir therapy]. | a 51 year old man developed herpes zoster on the right arm (c5/c6) treated subsequently with aciclovir infusions (500 mg, 3/day). ten months before hospital admission he did have a radical resection of a epi-oro-hypopharyngeal carcinoma (t4/n1/g2, m0; lymphangiosis carcinomatosa) as well as a partial laryngeal resection for a recurrence 3 months later and removal of a cervical lymph node metastasis after two further months. during aciclovir treatment the patient experienced repeated bradycardia ... | 1998 | 9865134 |
| [current results of the treatment of cervical metastatic lymph nodes by concurrent hyperfractionation of carboplatin and irradiation]. | the results of the treatment of metastatic neck nodes is evaluated after a mean follow-up of 24 months (maximum 45 months). fifty-seven patients with epidermoid carcinoma of the head and neck were treated according to a hyperfractionated chemoradiation schedule including two fractions a day. each fraction consisted of 10 mg carboplatin + 115 cgy. two fractions were given each day, five days a week, for a total dose of 700 mg carboplatin + 8050 cgy. whenever possible, surgical salvage was perform ... | 1998 | 9866222 |
| utility of third generation thyrotropin assays in thyroid function testing. | determination of thyrotropin (tsh) by sensitive immunometric assays is currently judged as the most sensitive and also most cost-effective first-line approach to thyroid function testing. further improvement of assay sensitivity has led to the description of third generation tsh assays with a functional sensitivity in the range of 0.01 to 0.02 mu/l. in the present study, we analyzed interassay precision profiles of a commercially available third generation assay (acs:180 tsh-3) and documented th ... | 1998 | 9867193 |
| thyrotropin-secreting pituitary adenoma. | thyrotropin (tsh)-secreting pituitary adenoma (tspa) is a rare cause of hyperthyroidism and detailed reports of this entity in taiwan are uncommon. we report a patient with tspa with symptoms of hyperthyroidism and describe the presentation, endocrine and histologic findings, and treatment. the patient, a 42-year-old man, presented with a 2-year history of weight loss, palpitation, anxiety, and bad temper. he had increased basal serum thyroxine (t4, 18.3 micrograms/dl) and triiodothyronine (t3, ... | 1998 | 9884490 |
| serum selenium levels in multinodular goitre. | serum selenium levels were measured in 22 patients with a multinodular goitre and compared to 15 normal controls using atomic absorption spectrophotometry. the serum selenium was significantly low in these patients (patients' mean = 9.6 +/- 1.24 mcg/l, versus control mean = 11.7 +/- 1.64 mcg/l and p < 0.005). serum t4 and t3 were within the normal range in all patients and controls. their levels correlated positively, though weakly, with the serum selenium levels (r = 0.4 and 0.36, respectively) ... | 1998 | 9884803 |
| repeated exposure of adult rats to aroclor 1254 causes brain region-specific changes in intracellular ca2+ buffering and protein kinase c activity in the absence of changes in tyrosine hydroxylase. | polychlorinated biphenyls (pcbs) are ubiquitous environmental contaminants, some of which may be neurotoxic. in vitro studies from this laboratory indicated that noncoplanar pcbs perturbed intracellular signal transduction mechanisms including ca2+ homeostasis, receptor-mediated inositol phosphate production, and translocation of protein kinase c (pkc). in the present study, we examined the effects of pcbs in vivo by dosing adult male long-evans rats orally with aroclor 1254 (0, 10, or 30 mg/kg/ ... | 1998 | 9878590 |
| [thyroid hormone production and its regulation]. | thyroid gland fulfills two functions. on one hand, it synthesizes and builds up stocks of thyroid hormones in thyroglobulin molecules of the colloid in its follicles, such as they can maintain the hormonal secretion during several days and even weeks. to do this, it captures and concentrates plasma iodide through a specific membrane transporter and it oxidizes iodide through the action of thyroperoxidase and h2o2. this makes it able to bind to tyrosine residus of thyroglobulin. then, the iodotyr ... | 1998 | 9881007 |
| [low t3 syndrome]. | many nonthyroidal illnesses are associated with reduced serum t3 and, in more severe conditions, t4 concentrations, without increased serum tsh secretion. the term euthyroid sick syndrome (ess) identifies these low t3 and low t3-t4 states. it may be difficult to exclude central hypothyroidism in patients admitted to medical intensive care units. the mortality rate has been found to be inversely correlated with the serum t4 concentration. these abnormalities are a consequence of altered hepatic t ... | 1998 | 9881012 |
| [thyrotropic deficiency]. | central hypothyroidism (thyrotropic deficiency) is due to a defect in tsh secretion by thyrotrophs (or alternatively to an altered bioactivity of tsh). central hypothyroidism is rare and is often associated with other pituitary deficiencies as it is generally encountered in case of hypothalamo-pituitary tumoral process. clinical symptoms are milder than those of primary thyroid failure. diagnosis is based on free t4 measurement whose level is decreased while tsh concentration is normal or minima ... | 1998 | 9881013 |
| the effect of electrical stimulation on colonic transit following spinal cord injury in cats. | the effect of direct electrical stimulation on colinic transit and manometric recordings following spinal cord injury were assessed in five adult male cats. intra-colonic catheters were surgically placed, stimulating electrodes were sutured to the colonic serosa and a laminectomy with spinal cord clamping at a t4 level was done to induce spinal cord injury (sci). twenty radiopaque markers were inserted through an intra-colonic catheter located 1 cm distal to the cecum and were monitored with dai ... | 1998 | 9881734 |
| post-operative thyroid status of patients with graves' disease is determined by the responsiveness of thyrocyte to tsh under the present thyroid gland remnant. | in order to determine whether thyrocyte responsiveness to tsh is correlated with post-operative thyroid status, thyrocytes obtained from 51 patients with graves' disease were cultured for 3 days. this was followed by culture with 10 mu/ml of tsh (tsh group) or without tsh (control group) for 3 additional days. on the 8th culture day, the amount of thyroglobulin (tg) secreted into the culture medium was assayed and the tg ratio (amount of tg from the stimulated group/amount of tg from the control ... | 1998 | 9881901 |
| angiogenesis in normal tissue adjacent to colon cancer. | angiogenesis in malignant neoplasms, as measured by microvessel density, has been shown to correlate with survival or stage in some studies of breast, gastric, and colorectal cancer. we hypothesized that aggressive cancers promote angiogenesis in normal tissue adjacent to the invading neoplasm. | 1998 | 9881940 |
| protection provided by exogenous dna ligase in g0 human lymphocytes treated with restriction enzyme mspi or bleomycin as shown by the comet assay. | dna double-strand breaks (dsb) may arise either spontaneously during cellular processes or as a result of exposure to dna-damaging agents such as ionizing radiation, or radiomimetic agents such as restriction endonucleases or bleomycin. it is widely accepted that nonrepaired or misrepaired dsb are the main lesions leading to the production of chromosomal aberrations, mutagenesis, oncogenic transformation, and cell killing. studies focusing on this relationship, as well as the possible modulation ... | 1998 | 9882008 |
| labeling efficiency of oligonucleotides by t4 polynucleotide kinase depends on 5'-nucleotide. | 1998 | 9882420 | |
| measurements of vertebral shape by radiographic morphometry: sex differences and relationships with vertebral level and lumbar lordosis. | to examine sex-related and vertebral-level-specific differences in vertebral shape and to investigate the relationships between the lumbar lordosis angle and vertebral morphology. | 1998 | 9730329 |
| prognostic assessment of 1310 patients with non-small-cell lung cancer who underwent complete resection from 1980 to 1993. | the tnm staging system of lung cancer is widely used as a guide for estimating prognosis and selecting treatment modality. in 1997, the international union against cancer and the american joint committee on cancer have adopted a revised stage grouping for lung cancer. however, the validity of the new stage grouping has not been fully established. we investigated the prognoses of patients who had resection of non-small-cell lung cancer to confirm the validity of the revised classification. | 1998 | 9731782 |
| validation of an eia kit for determination of total thyroid hormones in rat serum. effects of different anaesthetics. | two enzyme immunoassays for the quantitative determination of total thyroxine (t4) and total triiodothyronine (t3) in human serum were validated to measure total t4 and t3 in rat serum. the specificity, sensitivity, detectability and reproducibility have been tested as well as the effects of different anaesthetics (pentobarbital and a mixture of ketamine and xylacine) on serum thyroid hormone levels. hormones were quantified, by means of a previously validated technique, 18 hours after surgery f ... | 1998 | 9732104 |
| intramedullary lipoma of dorsocervicothoracic spinal cord with intracranial extension and hydrocephalus. | an intradural, intramedullary lipoma originating within the cervicothoracic cord with significant extension into the posterior fossa is reported. the lipoma was found incidentally by ct scan at the infant's age of 2 days. follow-up studies by ct and mri were performed on several occasions. because of hydrocephalus, vp shunting was performed. after shunting and shunt revisions, surgery of lipoma was performed at the age of 2 years. posterior fossa craniectomy and laminectomy from c1 to t4 reveale ... | 1998 | 9732259 |
| localization and characterization of two nucleotide-binding sites on the anaerobic ribonucleotide reductase from bacteriophage t4. | we have used 8-azidoadenosine 5'-triphosphate (8-n3atp) to investigate the nucleotide-binding sites on the nrdd subunit of the anaerobic ribonucleotide reductase from t4 phage. saturation studies revealed two saturable sites for this photoaffinity analog of atp. one site exhibited half-maximal saturation at approximately 5 microm [gamma-32p]8-n3atp, whereas the other site required 45 microm. to localize the sites of photoinsertion, photolabeled peptides from tryptic and chymotryptic digests were ... | 1998 | 9733790 |
| does feed restriction mimic the effects of increased ambient temperature in lactating sows? | we evaluated the effects of high ambient temperature and feed restriction in primiparous lactating sows. females were exposed to either a constant thermoneutral (20 degrees c) or hot environment (30 degrees c). lactating sows at 30 degrees c were given free access to feed (30al; n = 12), and sows at 20 degrees c were restricted according to the feed intake recorded at 30 degrees c (20rf; n = 6) or were given free access to feed (20al; n = 6). jugular vein catheters were surgically inserted at 10 ... | 1998 | 9734850 |
| probing rega/rna interactions using electrospray ionization-fourier transform ion cyclotron resonance-mass spectrometry. | the interactions of bacteriophage t4 rega protein, a unique translational regulator, with rnas of various size and sequence were studied using electrospray ionization-fourier transform ion cyclotron resonance-mass spectrometry. using very gentle interface conditions, rega/rna complexes with a 1:1 binding stoichiometry were observed for all four target rnas studied, consistent with solution binding studies. competitive binding of target rnas and their degradation products with rega demonstrated t ... | 1998 | 9735149 |
| functional neuromuscular stimulator for short-distance ambulation by certain thoracic-level spinal-cord-injured paraplegics. | functional neuromuscular stimulation (fns) for unbraced short-distance ambulation by traumatic complete/near-complete t4 to t12 paraplegics is based on work by graupe et al (1982), kralj et al (1980), liberson et al (1961), and others. this paper discusses methodology, performance, training, admissibility criteria, and medical observations for fns-ambulation using the parastep-i system, which is the first and only such system to have received fda approval (1994) and which emanated from these pre ... | 1998 | 9736079 |
| simultaneous formation of functional leading and lagging strand holoenzyme complexes on a small, defined dna substrate. | the biochemical characterization of leading and lagging strand dna synthesis by bacteriophage t4 replication proteins has been addressed utilizing a small, defined primer/template. the atp hydrolysis activity of 44/62, the clamp loading complex responsible for holoenzyme assembly, was monitored during assembly of both the leading and lagging strand holoenzyme complex. the atpase activity of 44/62 diminishes once a functional holoenzyme is assembled on both the leading and lagging strand. the ass ... | 1998 | 9736701 |
| etiologic study of primary congenital hypothyroidism. | the underlying causes of 35 children with primary congenital hypothyroidism at the children's hospital were studied. there were 21 girls and 14 boys. serum t4 and tsh level, 24 hours 131i uptake, and technetium-99m thyroid scintigraphy were performed after discontinuation of synthetic thyroid hormone for 4-6 weeks. athyrosis was the most common cause and accounted for forty-three per cent of the patients. twenty per cent of the patients had thyroid hypoplasia. ectopic thyroid was found in thirty ... | 1998 | 9737121 |
| prevalence of thyroid autoantibodies in children and adolescents from belarus exposed to the chernobyl radioactive fallout. | the long-term effects of ionising radiation, including radioiodine, on thyroid function are not well known. we compared thyroid immunity and function in two groups of children from belarus, one of whom was exposed to the radioactive fallout of chernobyl. | 1998 | 9737280 |
| effects of pharmacological fiber supplements on levothyroxine absorption. | to determine the effect of pharmacological fiber supplements, we measured levothyroxine (lt4) absorption without and with simultaneous ingestion of either calcium polycarbophil or psyllium hydrophilic mucilloid. serum thyroxine (t4) levels in 8 volunteers were measured following ingestion of 600 microg of lt4 on 3 separate occasions at 4-week intervals: (1) lt4 alone; (2) lt4 together with 1000 mg polycarbophil; and (3) lt4 together with 3.4 g psyllium. the amount of absorbed lt4 was calculated ... | 1998 | 9737361 |
| structure of d(gt)n.d(ga)n sequences: formation of parallel stranded duplex dna. | alternating polypurine sequences exhibit remarkable polymorphism. in this study, we report that dga.dgt sequences form parallel stranded duplex dna at neutral ph. using two model hairpins, 3'-d(gt)3-5'5'-t4(ag)3-3' (i) and 3'-d(gt)4-5'5'-t4(ag)4-3' (ii), containing 5'5' linkages which direct parallel strand formation, we systematically explored the spectroscopic and thermodynamic properties of parallel stranded d(ga)n.d(gt)n. the parallel stranded hairpins are remarkably stable structures with t ... | 1998 | 9737876 |
| [value and limits of surgery in stage iiib non-small-cell bronchial cancers]. | according to the tnm staging system for lung cancers, stage iii is divided into iiia and iiib. this division was based upon the principle that patients with iiia disease could theoretically benefit from complete resection, contrasting with iiib patients for whom surgery is not feasible. the poor prognosis of stage iiib is largely due to its classical inoperability. from the surgical point of view, stage iiib can be subdivided into four subgroups: 1) n3 where resection is possible in selected pat ... | 1998 | 9868402 |
| randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of adenocarcinoma of gastric cardia (agc)--report on 370 patients. | an attempt was made to define the role of radiotherapy before operation for agc. | 1998 | 9869212 |
| prognostic implications of downstaging following preoperative radiation therapy for operable t3-t4 rectal cancer. | to evaluate the prognostic value of tumor downstaging after preoperative radiation for resectable rectal cancer. | 1998 | 9869213 |
| carcinoma of the tonsillar fossa: prognostic factors and long-term therapy outcome. | to identify prognostic parameters and evaluate the therapeutic outcomes for patients with carcinoma of the tonsillar fossa treated with three treatment modalities. | 1998 | 9869232 |
| analysis of factors affecting long-term treatment results of adenoid cystic carcinoma of the nose and paranasal sinuses. | at akita university hospital (from 1971 to 1987) and at chiba university hospital (from 1983 to 1988), 17 patients with adenoid cystic carcinoma of the nose and paranasal sinuses were treated by en bloc tumor resection followed by primary reconstruction of the maxilla. pre- and postoperative radiation was combined in 5 and 6 patients, respectively. ten-year cancer-free survival rates were 59.3% in the 12 patients with maxillary sinus tumors and 50% in the 4 patients with nasal tumors. one patien ... | 1998 | 9870652 |
| [non-thyroid illness" or changed thyroid hormone parameter syndrome with non-thyroid illnesses]. | the multiple effects of systemic illness on thyroid economy are commonly referred to "non-thyroidal illness" (nti) or "sick euthyroid syndrome". the various aspects of this common syndrome are summarized in this article. | 1998 | 9872043 |
| autoimmune thyroid diseases and coeliac disease. | coeliac disease may be associated with a wide variety of diseases of known or suspected immunological aetiology. | 1998 | 9872614 |
| t3-4 squamous cell carcinoma of the larynx treated with radiation therapy alone. | this article reviews the results of radiation therapy alone for t3-4 squamous cell carcinoma of the larynx. local control after radiation therapy is approximately 65% for patients with t3 glottic and supraglottic carcinoma. the likelihood of local control is inversely related to tumor volume and, for those with glottic cancers, is adversely influenced by cartilage sclerosis on pretreatment computed tomography of the larynx. local control after radiotherapy is approximately 60% for t4 glottic can ... | 1998 | 9873104 |
| results of a prospective trial on elective modified radical classical versus supraomohyoid neck dissection in the management of oral squamous carcinoma. brazilian head and neck cancer study group. | elective treatment of the neck in oral squamous cell carcinoma has changed over the last 20 years. the main object of this report is to present the results of a multi-institutional prospective study designed to compare standard treatment with modified radical classical neck dissection (mrnd) to supraomohyoid neck dissection (soh) in the management of the clinically negative neck in oral cancer patients. | 1998 | 9874426 |
| is there a methimazole dose effect on remission rate in graves' disease? results from a long-term prospective study. the european multicentre trial group of the treatment of hyperthyroidism with antithyroid drugs. | the optimal antithyroid drug regimen for graves' disease remains a matter of controversy. the european multicentre trial group has investigated the effects of methimazole drug dose on the long-term outcome of graves' disease. | 1998 | 9876342 |
| endotoxins and endocrine system. | there is good evidence for the interaction of neuroendocrine and immune systems. endotoxin (lps)-induced mediators (e.g., cytokines, prostaglandins etc) set on endocrine organs (e.g., the hypothalamo-pituitry-adrenal axis; thyroid glands etc). endotoxin-treated, intestinal ischemic, or irradiated rats show decreased t4 levels of blood. these animals cannot respond to tsh because the tsh-receptors of follicular membranes are disturbed by lps in the thyroid glands. radiodetoxified endotoxin is an ... | 1998 | 9785034 |
| [influence on patients with sjögren's syndrome after the great hanshin-awaji earthquake]. | we investigated the influence of clinical findings on patients with sjögren's syndrome after the great hanshin-awaji earthquake. fifty eight (90%) of 64 patients were struck severely by the earthquake and 26 patients (42%) were forced to take refuge in emergency shelters. there was no aggravation of clinical findings or complications in eight patients inhabiting the area where the damage was mild. dry eyes were deteriorated in 14 patients (22%). dry mouth was aggravated in 6 patients (9%). howev ... | 1998 | 9785986 |
| [an influence of preop chemotherapy on the hormonal status of the patient with stomach cancer]. | in a gastric cancer patients it was established while examining the concentration of triiodothyronine (t3), thyroxin (t4), prolactin, hydrocortisone and insulin in a blood serum, that the chemotherapy conduction simultaneously with intensive preoperative schedule do not cause the hormone control disorders. it causes an absence of increase of postoperative complications occurrence and lethality as well. | 1998 | 9787563 |
| preoperative radiation with concurrent 5-fluorouracil continuous infusion for locally advanced unresectable rectal cancer. | to determine the percentage of complete responders and the resectability rate for patients with locally advanced carcinoma of the rectum treated by 5-fluorouracil (5-fu) infusional chemotherapy and pelvic radiation. | 1998 | 9788410 |
| irradiation in carcinoma of the vulva: factors affecting outcome. | this report reviews the increasing role of radiation therapy in the management of patients with histologically confirmed vulvar carcinoma, based on a retrospective analysis of 68 patients with primary disease (2 in situ and 66 invasive) and 18 patients with recurrent tumor treated with irradiation alone or combined with surgery. | 1998 | 9788413 |
| extending the indications for breast-conserving treatment to patients with locally advanced breast cancer. | breast-conserving therapy (bcs) has generally been limited to t1 and t2 lesions because it has been thought impossible to achieve good local control with satisfactory cosmesis in patients with more advanced disease. however, many patients with t3 and t4 lesions will exhibit dramatic tumor downstaging with neoadjuvant chemotherapy. it is our hypothesis that for these patients bcs can be performed with good local control and cosmesis. | 1998 | 9788414 |
| a viral suppressor of gene silencing in plants. | gene silencing is an important but little understood regulatory mechanism in plants. here we report that a viral sequence, initially identified as a mediator of synergistic viral disease, acts to suppress the establishment of both transgene-induced and virus-induced posttranscriptional gene silencing. the viral suppressor of silencing comprises the 5'-proximal region of the tobacco etch potyviral genomic rna encoding p1, helper component-proteinase (hc-pro) and a small part of p3, and is termed ... | 1998 | 9789044 |
| [evolution of diagnostic and therapeutic criteria in graves' disease in spain. comparison of the results of 2 surveys in 1987 and 1995]. | to assess the new diagnostic and therapeutic trends for hyperthyroidism due to graves' disease in spain and the differences with respect to a previous study performed in 1987. | 1998 | 9789225 |
| sexuality during pregnancy and the year postpartum. | there have been a few studies conducted on couples' sexual behavior during pregnancy and the year postpartum, but those studies contain sampling bias resulting from recruiting volunteers for sex research. the sample for the current research was recruited for a far less sensitive study, and includes data from both mothers and fathers. | 1998 | 9789517 |
| the effect of exercise training intensity on thyroid activity at rest. | the influence of exercise training intensity on thyroid activity at rest was studied in male wistar rats, weighting 114 g +/- 24 (mean +/- sd) at the beginning of the experiment. animals were assigned to the following groups: untrained controls and rats trained on a treadmill at the speed of 20 m/min over a 5-week period with different intensities: 2 x 60 min weekly, 4 x 60 min, 6 x 20 min, 6 x 40 min and 6 x 60 min weekly. thyroid peroxidase (tpo) and hepatic iodothyronine 5'-monodeiodinase (5' ... | 1998 | 9789797 |
| missense mutation (c1263r) in the thyroglobulin gene causes congenital goiter with mild hypothyroidism by impaired intracellular transport. | metabolic abnormalities in thyroid hormonogenesis cause congenital goiter. here we studied a case of mild hypothyroidism caused by a novel missense mutation in the thyroglobulin (tg) gene. a female patient underwent thyroidectomy twice at the age of 27 and 43 years because of gradual enlargement of the thyroid. by rnase cleavage assay and pcr direct sequencing we identified a thymine to cytosine transition at nucleotide 3828 (from the transcription start site) which causes amino acid change from ... | 1998 | 9790265 |
| thyroxine (t4) metabolism in an athyreotic patient who had taken a large amount of t4 at one time. | as we had an opportunity to take blood samples from a totally thyroidectomized patient who had attempted suicide by taking 2,000 microg of levothyroxine (l-t4), the serum levels of thyroid hormones were sequentially measured to investigate the metabolism of circulating thyroid hormones in an athyreotic human. the serum concentrations of most thyroid hormones reached a peak on the second day, but the serum t3 level showed a peak one day later. the maximum concentrations of t4 (315 microg/l), ft4 ... | 1998 | 9790272 |
| amyloid goiter presented as a subacute thyroiditis-like symptom in a patient with hypersensitivity vasculitis. | we present a 25-year-old woman with amyloid goiter due to hypersensitivity vasculitis, who developed transient thyrotoxicosis resembling subacute thyroiditis. she received prednisolone (20 mg/ day) for three years for hypersensitivity vasculitis, and was diagnosed as having secondary amyloidosis by biopsies of the stomach, rectum and kidneys. she noticed neck swelling with severe right neck tenderness, palpitation, hyperhidrosis and weight loss. an elastic firm diffuse goiter was palpable, and t ... | 1998 | 9790279 |
| long term results of primary radiotherapy with/without neck dissection for squamous cell cancer of the base of tongue. | there are several management options for patients with squamous cell cancer of the base of tongue. we have had an interest in using primary radiotherapy with or without neck dissection, in an effort to provide optimal oncologic as well as functional outcomes. | 1998 | 9790286 |
| single-stranded dna binding properties of the uvsx recombinase of bacteriophage t4: binding parameters and effects of nucleotides. | bacteriophage t4 provides an important model for the biochemistry and genetics of dna metabolism. phage-encoded proteins conduct all essential steps of t4 dna replication, repair, and recombination. central to these three processes is the t4 uvsx protein, a member of the filamentous, atp-dependent class of general recombination enzymes typified by the escherichia coli reca protein. like reca, uvsx forms presynaptic filaments on single-stranded (ss) dna, which are the obligatory nucleoprotein int ... | 1998 | 9790840 |
| identification of the nuclease active site in the multifunctional recbcd enzyme by creation of a chimeric enzyme. | the recombinational hot spot chi modulates the nuclease and helicase activities of the recbcd enzyme, leading to generation of an early dna intermediate for homologous recombination. here we identify the subunit location of the nuclease active site in recbcd. the isolated recb protein cleaves circular single-stranded m13 phage dna, but recb1-929, comprising only the 100 kda n-terminal domain of recb, does not. we reported previously that the reconstituted recb1-929cd enzyme also is not a nucleas ... | 1998 | 9790841 |
| interaction of recbcd enzyme with dna at double-strand breaks produced in uv-irradiated escherichia coli: requirement for dna end processing. | the recbcd enzyme has a powerful duplex dna exonuclease activity in vivo. we found that this activity decreased strongly when cells were irradiated with uv light (135 j/m2). the activity decrease was seen by an increase in survival of phage t4 2(-) of about 200-fold (phage t4 2(-) has defective duplex dna end-protecting gene 2 protein). the activity decrease depended on excision repair proficiency of the cells and a postirradiation incubation. during this time, chromosome fragmentation occurred ... | 1998 | 9791113 |
| delineation of an evolutionary salvage pathway by compensatory mutations of a defective lysozyme. | model-free approaches (random mutagenesis, dna shuffling) in combination with more "rational," three-dimensional information-guided randomization have been used for directed evolution of lysozyme activity in a defective t4 lysozyme mutant. a specialized lysozyme cloning vector phage, derived from phage lambda, depends upon t4 lysozyme function for its ability to form plaques. the substitution w138p in t4 lysozyme totally abolishes its plaque-forming ability. compensating mutations in w138p t4 ly ... | 1998 | 9792108 |
| continuous positive airway pressure requirement during the first month of treatment in patients with severe obstructive sleep apnea. | (1) to compare the continuous positive airway pressure (cpap) requirement at the time of diagnosis (t0), after 2 weeks (t2), and after 4 weeks (t4) of cpap treatment, in patients with severe obstructive sleep apnea (osa); and (2) to assess whether any alteration in cpap requirement over the first 4 weeks of cpap treatment would influence daytime alertness, subjective sleepiness, or mood. | 1998 | 9792578 |
| cloning of a novel member of the udp-galactose:beta-n-acetylglucosamine beta1,4-galactosyltransferase family, beta4gal-t4, involved in glycosphingolipid biosynthesis. | a novel putative member of the human udp-galactose:beta-n-acetylglucosamine beta1,4-galactosyltransferase family, designated beta4gal-t4, was identified by blast analysis of expressed sequence tags. the sequence of beta4gal-t4 encoded a type ii membrane protein with significant sequence similarity to other beta1,4-galactosyltransferases. expression of the full coding sequence and a secreted form of beta4gal-t4 in insect cells showed that the gene product had beta1,4-galactosyltransferase activit ... | 1998 | 9792633 |
| allosteric regulation of vaccinia virus ribonucleotide reductase, analyzed by simultaneous monitoring of its four activities. | as determined by simultaneous monitoring of its four activities, vaccinia virus-coded ribonucleoside diphosphate (rndp) reductase shows responses to individual nucleoside triphosphate effectors-atp, datp, dgtp, and dttp-similar to those previously reported for rndp reductase of mouse, which the viral enzyme closely resembles. this investigation uses the vaccinia enzyme as a readily available and convenient model for understanding the cellular enzyme. as previously reported for t4 phage aerobic r ... | 1998 | 9792658 |
| comparison of the effects of thyroxine and triiodothyronine on protein turnover and apoptosis in primary chick muscle cell cultures. | primary chick muscle cells were treated with physiological level of thyroxine (t4) or triiodothyronine (t3) to examine the effects of the hormones on growth, protein turnover, and apoptosis of the cells. creatine kinase activity, as an index of differentiation, was increased by both t4 and t3. even when the conversion from t4 to t3 was blocked by iopanoic acid, t4 increased creatine kinase activity. the rate of protein degradation estimated from [3h] tyrosine release was increased by t3 but not ... | 1998 | 9792793 |
| [prevalence of endemic goiter in the health sector of zitenga (burkina faso)]. | the prevalence of iodine deficiency disorders (idd) was studied in the health district of zitenga village (oubritenga province, burkina faso), as part of an assisted development program. the study was designed to assess the prevalence of idd in a population of more than 2,000 people. a multistage cluster sample of 210 people was randomly selected. the women in the sample were aged 0 to 45 years and the men, 0 to 25 years. clinical and laboratory results (circulating tsh concentration, t4 and iod ... | 1998 | 9794037 |
| direct measurement of the contributions of type i and type ii 5'-deiodinases to whole body steady state 3,5,3'-triiodothyronine production from thyroxine in the rat. | production of t3 from t4 in tissues is catalyzed by two 5'-deiodinases, type i (d1) and type ii (d2), but the quantitative contribution of each pathway to whole body t3 production is not well established. in the presence of propylthiouracil (ptu), d1, but not d2, can be effectively blocked, providing an experimental probe for addressing this problem. decades ago, this approach provided indirect estimates ranging from 23-44% contribution by d2, based on plasma t3 appearance rate comparisons (par3 ... | 1998 | 9794474 |
| outcome of graves' disease after antithyroid drug treatment in taiwan. | the outcome of graves' disease after treatment with antithyroid drugs (atds) varies widely among countries, and large-scale studies in asia are rare. we investigated the associations of various clinical and laboratory features with the outcome of atd therapy for graves' disease in taiwan. a total of 210 patients (177 women, 33 men; mean +/- sd age, 41.7 +/- 15.1 yr) treated with atd in taiwan were included. atd therapy started with methimazole 30 mg daily or propylthiouracil 300 mg daily and was ... | 1998 | 9795530 |
| polymorphism within the cyclin d1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. | we have examined the correlation of a frequent a/g polymorphism within exon 4 of the cyclin d1 gene (ccnd1) with genetic susceptibility and clinical outcome in 384 patients with squamous cell carcinoma (scc) of the head and neck. ccnd1 genotype frequencies were similar in the cases and 191 controls. furthermore, the ccnd1 genotype was not associated with susceptibility to scc of the larynx, pharynx, or oral cavity. the influence of the ccnd1 genotype on clinical outcome was also assessed. we fou ... | 1998 | 9796972 |
| neonatal transient hypothyroidism: aetiological study. italian collaborative study on transient hypothyroidism. | to define the aetiology of neonatal transient hypothyroidism (nth) and recommend preventive measures. | 1998 | 9797631 |
| vertebral fracture assessment using the lateral scoutview of computed tomography in comparison with radiographs. | semiquantitative vertebral fracture assessment was compared between lateral computed tomography (ct) scoutviews and conventional thoracolumbar spinal radiographs. vertebral levels t4-l4 were assessed by both techniques in a group of 56 women (mean age 60 +/- 13 years). in order to compare inter- and intra-observer variabilities for the two techniques, the images were analyzed twice by two independent observers, and percentage agreement and kappa statistics were measured both between readings and ... | 1998 | 9797902 |
| activity of foreign proteins targeted within the bacteriophage t4 head and prohead: implications for packaged dna structure. | the phage-derived expression, packaging, and processing (pepp) system was used to target foreign proteins into the bacteriophage capsid to probe the intracapsid environment and the structure of packaged dna. small proteins with minimal requirements for activity were selected, staphylococcal nuclease (sn) and green fluorescent protein (gfp). these proteins were targeted into the t4 head by means of ipiii (internal protein iii) fusions or cts (capsid targeting sequence) fusions. additional evidenc ... | 1998 | 9799633 |
| the prognostic value of proliferating cell nuclear antigen (pcna) in the advanced cancer of larynx. | it was retrospectively examined whether the tumor growth fraction determined by pcna score in the advanced cancer of larynx could be used as a prognostic factor. there was used immunohistochemical method to evaluate the pcna score of positive cells in paraffin embedded tissues of laryngeal carcinoma obtained from 90 patients. they were treated by surgery in the department of otolaryngology at the medical university in cracow, poland in 1987 and 1988. the follow-up period was not shorter than 5 y ... | 1998 | 9799997 |