Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| dissecting the order of bacteriophage t4 dna polymerase holoenzyme assembly. | most biological organisms rely upon a dna polymerase holoenzyme for processive dna replication. the bacteriophage t4 dna polymerase holoenzyme is composed of the polymerase enzyme and a clamp protein (the 45 protein), which functions as a processivity factor by strengthening the interaction between dna and the holoenzyme. the 45 protein must be loaded onto dna by a clamp loader atpase complex (the 44/62 complex). in this paper, the order of events leading to holoenzyme formation is investigated ... | 1998 | 9601035 |
| specific binding of l-triiodothyronine modulates na(+)-k(+)-atpase activity in adult rat cerebrocortical synaptosomes. | interactions of l-triiodothyronine (t3) in adult rat cerebrocortical synaptosomes were studied in vitro. scatchard plot analysis revealed two sets of t3 binding sites. the degree of saturation of t3 binding sites (putative receptor) correlated well with the dose-dependent inhibition of na(+)-k(+)-atpase activity in synaptosomes. the relative binding affinities and relative inhibition of enzyme activities for different th analogues were l-t3 > t3-amine > triac = l-t4 > r-t3 > t2 and l-t3 > t3-ami ... | 1998 | 9601684 |
| hepatic enzyme induction and acute endocrine effects of 2,3,3',4',6-pentachlorobiphenyl in prepubertal female rats. | polychlorinated biphenyls (pcbs) with the labile 2,3,6-substitution are important components of atmospheric and certain food chain exposures, but little is known about their biological activities. chlorobiphenyl 110 (2,3,3',4',6-pentacb) was investigated in weanling female rats dosed ip on days 21 and 22 and killed on day 23 of age. the initial preparation of cb 110 markedly induced 7-ethoxyresorufin o-dealkylase (erod) activity and was found to be contaminated with coplanar 3,3',4,4',5-pentacb ... | 1998 | 9601926 |
| endothoracic sonography with color doppler availability during video assisted thoracic surgery (videothoracoscopic operative staging with ultrasound color doppler) for lung cancer staging. | the preoperative staging of lung cancer can be problematical when we attempt to evaluate t factor (t2-t3 versus t4) and n factor (n0 versus n1-n2). in some cases, radiology tests (ct scan, magnetic resonance imaging) cannot entirely dispel the possibility that the mediastinal structures have been infiltrated. n factor is evaluated mainly by dimensional criteria. however, mediastinoscopy and mediastinotomy do not allow the full exploration of all mediastinal mode stations. | 1998 | 9601997 |
| effects of cisatracurium in children during halothane-nitrous oxide anesthesia. | to determine the neuromuscular blocking effect and recovery profile of cisatracurium besylate in children after administration of a bolus dose that was twice the estimated dose required to produce 95% of the maximum effect (2 x ed95; 0.08 mg/kg) followed by an infusion during halothane-nitrous oxide anesthesia. | 1998 | 9603588 |
| occurrence of a sequence in marine cyanophages similar to that of t4 g20 and its application to pcr-based detection and quantification techniques. | viruses are ubiquitous components of marine ecosystems and are known to infect unicellular phycoerythrin-containing cyanobacteria belonging to the genus synechococcus. a conserved region from the cyanophage genome was identified in three genetically distinct cyanomyoviruses, and a sequence analysis revealed that this region exhibited significant similarity to a gene encoding a capsid assembly protein (gp20) from the enteric coliphage t4. the results of a comparison of gene 20 sequences from thre ... | 1998 | 9603813 |
| effect of storage conditions on cortisol, total thyroxine, and free thyroxine concentrations in serum and plasma of dogs. | to determine for dogs stability of cortisol, thyroxine (t4), and free thyroxine (ft4) in plasma and serum stored in glass or plastic tubes at -20, 4, 25, and 37 c. | 1998 | 9604024 |
| effect of time of sample collection on serum thyroid-stimulating hormone concentrations in euthyroid and hypothyroid dogs. | to determine effect of time of sample collection on serum thyrotropin (canine thyroid-stimulating hormone [ctsh]) concentrations in euthyroid and hypothyroid dogs. | 1998 | 9604026 |
| the value of cyfra 21-1, a new tumor marker, in nasopharyngeal carcinoma. | cyfra 21-1 (cyfra) is a newly-developed tumor marker which is useful in evaluating non-small cell lung carcinoma, especially the squamous cell type. the purpose of this study was to assess the clinical value of cyfra in patients with nasopharyngeal carcinoma (npc). serum levels of cyfra (cis bio-international, france) were measured in 80 patients with untreated npc. the histologic diagnosis of all patients was confirmed by biopsy. twenty two (27.5%) of the tumors were classified as undifferentia ... | 1998 | 9604997 |
| use of the single-cell gel electrophoresis assay for the immunofluorescent detection of specific dna damage. | the single-cell gel electrophoresis assay or comet assay is now a widely used method to assess the level of dna damage in irradiated or chemically modified cells. we propose an adaptation of the currently applied protocol, aimed at singling out a defined modified base, using an immunodetection approach. after the electrophoresis step, the dna tail moment was measured using ethidium bromide. simultaneously, cyclobutane pyrimidine dimers (cpds), the targeted lesions, were revealed by an indirect i ... | 1998 | 9606136 |
| differences in thyroid function between bipolar manic and mixed states. | high rates of thyroid axis abnormalities have been reported in most studies of patients with rapid-cycling bipolar disorder. mixed states share similarities with rapid-cycling, including close temporal occurrence of manic and depressive symptoms, predominance in women, poor outcome, and less robust response to lithium compared with pure mania; however, thyroid axis abnormalities have not been well studied in mixed mania. | 1998 | 9606526 |
| endocrine responses to weaning and changes in post-weaning diet in the young pig. | the effects of weaning and changing post-weaning diet composition on growth patterns and growth-related hormonal profiles were evaluated in neonatal pigs. forty-eight crossbred piglets were assigned to two groups (n = 24/group) based on weaning at 2 or 3 wk of age (2w and 3w groups. respectively). at weaning, piglets were removed from the sow and placed on a commercial starter ration for the first 11 d post-weaning (phase i diet). at day 12 post-weaning, pigs were placed on a growing ration for ... | 1998 | 9606600 |
| value of sextant biopsies in the assessment of local cure following external beam radiotherapy of prostatic adenocarcinoma. | between 1982 and 1992, 73 patients received radical external beam radiotherapy (ebr) for prostatic adenocarcinoma at the central hospital, västerås, with an average dose of 68.1 gy (range 64.5-72.5 gy) and an average cumulative radiation effect (cre) of 18.2 (range 17.1-19.9) all patients had a negative bone scan prior to treatment and presented with clinical stage t1-t4,nx,mo. twenty-four out of 36 surviving patients consented to participate in a follow-up study which included transrectal, ultr ... | 1998 | 9606782 |
| [endoscopic ultrasonography in the staging of esophageal cancer. therapeutic implications]. | endoscopic ultrasonography (eus) provides accurate visualization of the different layers of the gastrointestinal wall and surrounding structures, allowing tn staging of tumors prior surgery. the aim of this study was to evaluate the sensitivity, specificity and accuracy of eus in the staging of esophageal carcinoma as well as its applicability and usefulness in tumors with nontraversable stenoses. eus was performed in 43 patients with esophageal carcinoma. the technique was carried out with a ra ... | 1998 | 9607290 |
| antiparallel dna duplex formation between alternating alpha d(ga)n and beta d(ga)n sequences. | alternating polypurine d(ga)n, sequences exhibit a considerable polymorphism. here we report that alpha d(ga) x d(ga) sequences form an antiparallel stranded duplex dna at neutral ph. the spectroscopic, electrophoretic and thermodynamic properties of the alpha/beta chimeric oligodeoxynucleotide, 5'-d(ga)4(t)4 alpha d(ag)4t-3', support the formation of a hairpin structure with antiparallel strands in the stem. the optical properties of this novel antiparallel structure are different from the para ... | 1998 | 9607333 |
| ethmoid sinus cancer: twenty-nine cases managed with primary radiation therapy. | to describe the outcome of patients with carcinoma of the ethmoid sinus managed with a policy of primary radiation therapy with surgery for salvage of persistent or progressive disease. | 1998 | 9607352 |
| locally recurrent nasopharyngeal carcinoma: treatment results for patients with computed tomography assessment. | to study the treatment outcome in patients with locally recurrent nasopharyngeal carcinoma as restaged by computed tomography (ct). | 1998 | 9607354 |
| preoperative serum vascular endothelial growth factor can predict stage in colorectal cancer. | neovascularization has been shown to be essential for the growth of solid tumors. vascular endothelial growth factor (vegf) is one of the most important mediators of angiogenesis. this study was conducted to determine the significance of this cytokine as a tumor marker for staging colorectal cancer. preoperative serum vegf was measured in 108 colorectal cancer patients and in 136 normal healthy controls. the results of this study showed a significant difference between the four t classes, union ... | 1998 | 9607588 |
| fasting-induced increase in type ii iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus. | the importance of local formation of t3 in the feedback effect of the thyroid gland on hypothalamic trh-producing cells has been established. primary failure of the thyroid gland results in a fall in circulating t4 and t3 levels, leading to an elevation in the production and release of trh in the hypothalamic paraventricular nucleus. in contrast, during short term fasting, declining plasma levels of thyroid hormones coincide with suppressed trh production and release. in the brain, the prevalent ... | 1998 | 9607797 |
| the decrease of liver ldl receptor mrna during fasting is related to the decrease in serum t3. | fasting is associated with a reduction in serum t3 and t4 and a rise of plasma ldl cholesterol. we hypothesized that an hypothyroid-like condition induced by fasting is responsible for the rise in ldl cholesterol. we therefore examined the relation between changes in thyroid hormone and cholesterol metabolism in rats fasted for 0, 8, 12, 24 or 48 h. fasting resulted in a decrease of liver 5'-deiodinase mrna from 8 h (to 50%, p < 0.05, n = 6), of serum t3 from 12 h and of serum t4 at 48 h; serum ... | 1998 | 9608674 |
| nocturnal increases in the triiodothyronine/thyroxine ratio in the rat thymus and pineal gland follow increases of type ii 5'-deiodinase activity. | the type ii 5'-deiodinase (5'd-ii) is regulated by the light-dark cycle in some tissues in which the enzyme is present. this prompted us to investigate putative influences of light-dark cycle on thyroid hormone concentrations in these tissues. the results revealed the following facts: (a) deiodinase activity in the rat thymus exhibits a nyctohemeral profile with peak values late at night and basal values during the day. the thyroid hormone concentrations in the thymus also show a 24 h rhythm wit ... | 1998 | 9608677 |
| flexibility of the thyroiditogenic t cell repertoire for murine autoimmune thyroiditis in cd8-deficient (beta2m -/-) and t cell receptor vbeta(c) congenic mice. | in murine experimental autoimmune thyroiditis (eat), previous studies have revealed a highly adaptable thyroiditogenic t cell repertoire which involves both cd4+ and cd8+ t cells in the susceptible h2k strain. to further test this flexibility, congenic b10.k mice lacking cd8+ t cells (b2m -/-) or harboring 70% t cell receptor (tcr) vbeta gene deletions (vbeta(c)) were immunized with mouse thyroglobulin (mtg) and evaluated for eat 28 days later. all b2m -/- mice developed moderate antibodies to m ... | 1998 | 9609129 |
| transmural care of terminal cancer patients: effects on the quality of life of direct caregivers. | the burden of caring for terminal cancer patients has a negative effect on the informal caregivers' quality of life. | 1998 | 9610646 |
| thyroid function in postmenopausal women with breast cancer on tamoxifen. | in 42 postmenopausal women with breast cancer, aged 48-85 years (mean age 62.4 years) serum thyroid hormone concentrations were measured before and after 6 months of tamoxifen therapy (20 mg daily). in particular triiodothyronine (t3), thyroxine (t4), free triiodothyronine (ft3), free thyroxine (ft4), thyroxine-binding globulin (tbg) and thyroid-stimulating hormone (tsh) concentrations before and 30 minutes after thyrotrophin-releasing hormone (trh) administration (200 microg i.v.) were measured ... | 1998 | 9611055 |
| characterization of werner syndrome protein dna helicase activity: directionality, substrate dependence and stimulation by replication protein a. | werner syndrome is an inherited disease characterized by premature aging, genetic instability and a high incidence of cancer. the wild type werner syndrome protein (wrn) has been demonstrated to exhibit dna helicase activity in vitro. here we report further biochemical characterization of the wrn helicase. the enzyme unwinds double-stranded dna, translocating 3'-->5' on the enzyme-bound strand. hydrolysis of datp or atp, and to a lesser extent hydrolysis of dctp or ctp, supports wrn-catalyzed st ... | 1998 | 9611231 |
| [combined deficiency of thyroid stimulating hormone and growth hormone in a diabetic patient with hashimoto thyroiditis]. | we report the case of a 36-year-old female patient with insulin dependent diabetes who developed hypothyroidism of pituitary origin after giving birth. she had low levels of free t4 and tsh with no response to i.v. trh. antimicrosome antibodies were increased (1/25000), suggesting hashimoto's thyroiditis. the other hormones were normal except for a low level of growth hormone and insulin growth factor 1. there were no antibodies against the pituitary. mri of the pituitary was normal. we suspect ... | 1998 | 9614334 |
| pre-autoimmune thyroid abnormalities in the biobreeding diabetes-prone (bb-dp) rat: a possible relation with the intrathyroid accumulation of dendritic cells and the initiation of the thyroid autoimmune response. | thyroid autoimmune reactions start with an accumulation of mainly dendritic cells in the thyroid. there is increasing evidence that, apart from being antigen-presenting cells, they are also able to control the growth and hormone synthesis of neighbouring endocrine cells. the questions thus arise: are dendritic cells accumulating in the pre-autoimmune thyroid in response to an altered proliferative or metabolic activity of thyrocytes, and do cytokines, monocyte chemoattractants, or both, have a r ... | 1998 | 9614356 |
| antenatal triiodothyronine improves neonatal pulmonary function in preterm lambs. | to characterize 1) pulmonary gas exchange, 2) pulmonary function, 3) lung fluid and tissue phospholipid content, and 4) thyroid hormone in the premature lamb (0.85 of term) after intra-amniotic administration of 100 micrograms of triiodothyronine (t3) 2 weeks before delivery. | 1998 | 9614640 |
| [locally advanced prostate carcinoma (t2b-t4 n0) without and with clinical evidence of local progression (tx n+) with lymphatic metastasis. is radiotherapy for pelvic lymphatic metastasis indicated or not?]. | there is a greater controversy regarding the indication of radiotherapy of the pelvic lymphatics in patients with suspected lymph node metastases in locally advanced prostate cancer (t2b-4 n0) on the one hand and in patients with pathologically proven lymph node metastases in locoregional advanced prostate cancer (tx pn+) on the other hand following definitive radiotherapy and radical prostatectomy. this paper investigates the possible indications for radiotherapy of the pelvic lymphatics in the ... | 1998 | 9614950 |
| effects of 6-n-propyl-2-thiouracil on growth, hormonal profiles, carcass and reproductive traits of boars. | neonatal 6-n-propyl-2-thiouracil (ptu)-induced hypothyroidism reduces body weight but increases testicular size in adult male rodents. the objective of this study was to determine the effect of prepubertal ptu treatment on boars. for experiment i, boars (n = 28) were randomly allotted to eight pens. each pen received one of four ptu doses (0, 0.01, 0.03 and 0.1% in a basal diet) between 28 and 56 days of age (doa). due to a lack of difference among three ptu treatments, ptu-treated boars were po ... | 1998 | 9615182 |
| changes in circulating lh, sex steroid hormones, thyroid hormones and corticosterone in relation to breeding and molting in captive humboldt penguins (spheniscus humboldti) kept in an outdoor open display. | penguins are highly adapted to marine life. their hydrodynamic efficiency depends on feathers which wear with age and need to be replaced regularly. during molting, penguins can not enter the sea to forage and are forced to fast. therefore the duration of molting is necessarily brief. to better understand molting in penguins, we collected plasma samples from 16 (8 pairs) humboldt penguins kept in an open display pen at tokyo sea life park from may to september, 1994 and estimated circulating con ... | 1998 | 9615622 |
| thyroid hormone concentrations and muscle metabolism in amenorrheic and eumenorrheic athletes. | the relationship between resting thyroid hormone concentrations and exercise muscle metabolism was examined among eumenorrheic endurance-trained (n = 11), amenorrheic endurance-trained (n = 8), and eumenorrheic nonathletic (n = 13) subjects. muscle metabolism was assessed with 31phosphorous magnetic resonance spectroscopy by measuring changes in phosphocreatine (pcr), inorganic phosphate (pi), and ph during plantar flexion exercise and recovery. all groups had similar pi/pcr ratios and ph change ... | 1998 | 9615871 |
| effect of thyroid hormone on plasma apolipoproteins and apoa- and apob-containing lipoprotein particles. | apolipoprotein and apob- and apoa-containing lipoprotein particle concentrations were determined in 10 athyreotic patients 4 weeks after withdrawal of synthroid replacement therapy [t4, 0.96 +/- 0.66 microgram ml-1; thyroid-stimulating hormone (tsh), 62.7 +/- 22.8 muiu ml-1] and again 4 weeks after reinstitution of treatment. | 1998 | 9615901 |
| bronchoalveolar lavage causes decrease in pao2, increase in (a-a) gradient value and bronchoconstriction in asthmatics. | the aims of this study were to (1) record the changes of (arterial oxygen partial pressure) pao2, (arterial carbon dioxide partial pressure) paco2, (percentage saturation of haemoglobin with oxygen in arterial blood) sao2 and alveolar-arterial (a-a) oxygen gradiant resulting from bronchoalveolar lavage (bal) in asthmatic and normal subjects; (2) measure changes in forced expiratory volume in 1 s (fev1), vital capacity forced (fvc) associated with bal; and (3) assess possible predictive factors f ... | 1998 | 9616511 |
| [combination of transcatheter arterial infusion of smancs and embolization (smancs-tae) for hepatocellular carcinoma--second report]. | patients with unresectable hepatocellular carcinoma (hepatoma) with hypervascularity were treated by smancs-tae. a superselective catheterization technique was used to inject gelatin sponge particles after administration of smancs. in 30 patients of first hepatoma treated by smancs-tae. grade 4 was obtained after 1.7(1-3) courses. the 2-year survival rate was 22%. some of the 24 patients of second hepatoma treated by smancs-tae have survived over 2 years. sixteen patients with advanced hepatoma ... | 1998 | 9617326 |
| [tnm classification of brain tumor]. | tm staging proposed by uicc was classified mainly by histology and tumor size (extension). staging trial was done by using the data of astrocytic tumor cases of the supratentorial region collected both during the periods between 1978 to 1987 by the brain tumor registry of japan (permission for publication: sep. 1994). survival curves classified by t classification in each histology, such as astrocytoma, malignant astrocytoma, glioblastoma, showed a great differences from each other, even at the ... | 1998 | 9617336 |
| a plant transformation vector with a minimal t-dna ii. irregular integration patterns of the t-dna in the plant genome. | a minimal t-dna binary vector was used for agrobacterium-mediated transfer of a chimeric t4 lysozyme gene located next to the left border, and transgenic potato plants which expressed t4 lysozyme protein were identified and further analysed. frequent rearrangements of t4 lysozyme transgenes were detected. a vector derivative containing two matrix associated regions (mars) flanking its multiple cloning site was constructed. in transgenic potato plants, reduced variability in gene expression due t ... | 1998 | 9617825 |
| quantitative reverse transcription strand displacement amplification: quantitation of nucleic acids using an isothermal amplification technique. | recent advances in nucleic acid amplification techniques have allowed for quantitation of viral nucleic acid levels in clinical specimens. the most prevalent testing is carried out for hiv viral load. strand displacement amplification (sda) is an isothermal dna amplification system utilizing a restriction enzyme and a dna polymerase with strand displacement properties. sda was adapted for quantitative rna amplification (qrt-sda) of an hiv gag sequence by including amv reverse transcriptase, a qu ... | 1998 | 9618201 |
| sucrase-isomaltase ontogeny: synergism between glucocorticoids and thyroxine reflects increased mrna and no change in cell migration. | during postnatal maturation of the rat small intestine, glucocorticoid hormones (gc) and thyroxine (t4) act synergistically to elicit a precocious increase of sucrase activity. the current work shows that the synergistic effect on sucrase activity is paralleled by increased steady-state levels of sucrase-isomaltase mrna. the enhancing effects of t4 on dexamethasone (dex)-induced sucrase activity was seen even after prolonged treatment (9 days). moreover, when the location of sucrase-bearing cell ... | 1998 | 9618286 |
| [axillary node removal in clinical node-negative breast carcinoma. can its indication be individualized by "sentinel node" detection?]. | the status of the axillary lymph node(s) is an important prognostic factor in breast cancer and thus decisive in the indication for adjuvant treatment. this study investigated the extent to which examination of the sentinel node (sn) can individualize the need for axillary resection and the diagnosis of lymph nodes be optimized. | 1998 | 9618639 |
| effect of selective substitution of 5-bromocytosine on conformation of dna triple helices. | three triplex dnas containing 5-bromocytosine[brc] were studied by vibrational spectroscopy and molecular modelling. firstly, three oligodeoxypyrimidines of 5'-(tc)3-t4-(brct)3 [cbrc], 5'-(tbrc)3-t4-(ct)3 [brcc] and 5'-(tbrc)3-t4-(brct)3 [brcbrc] were synthesized and then reacted with an oligodeoxypurine of 5'-(ag)3 at ph=4.5 in phosphate buffer respectively to form three comparative hairpin triplex named cy,yc and yy. the results of ft-raman and ir revealed that yy is almost in a-like form, cy ... | 1998 | 9619512 |
| rad52 forms ring structures and co-operates with rpa in single-strand dna annealing. | the rad52 epistasis group in saccharomyces cerevisiae is involved in various types of homologous recombination including recombinational double-strand break (dsb) repair and meiotic recombination. a reca homologue, rad51, plays a pivotal role in homology search and strand exchange. genetic analysis has shown that among members of its epistasis group, rad52 alone is required for recombination between direct repeats yielding deletions. very little has been discovered about the biochemical roles an ... | 1998 | 9619627 |
| infrapetiole exploration of the supraglottis for exposure of the anterior glottal commissure. | effective microlaryngoscopic surgery of the anterior glottal commissure depends on adequate exposure of this region. despite the use of elevated vector suspension and external laryngeal counter-pressure, there are some individuals in whom inadequate exposure precludes execution of the planned surgery. to solve this problem, a procedure was designed in which the anterior vestibular folds and the infrapetiole region of the supraglottis are resected to facilitate complete exposure of the broyle's l ... | 1998 | 9619988 |
| immunoregulatory mechanisms and stress hormones in psoriasis (part 1) | in an earlier paper, the author noted that psoriatic eruptions may be produced in phases of humoral and cellular immunodeficiency and in the presence of streptococcal antigen-releasing inflammatory foci. in this study it was investigated as to whether stress hormones glucocorticoids, catecholamines) are substantially involved in the activity phases (eruptions) of psoriasis. | 1998 | 9620481 |
| the effects of thyroid hormone modulation on rat liver injury associated with ischemia-reperfusion and cold storage. | we investigated the effects of thyroid hormone modulation on liver injury associated with ischemia-reperfusion (i-r) and cold storage in rats. first, euthyroid and thyroxine (t4)-pretreated rats were exposed in vivo to 20-min global liver ischemia, then 30-min reperfusion. liver injury was assessed by measuring serum alanine aminotransferase (alt) levels. liver concentrations of adenine nucleotides, reduced glutathione (gsh), and oxidized glutathione were evaluated. second, rats were given the a ... | 1998 | 9620501 |
| [the function of the thyroid and thyrotropic function in patients with chronic ischemic heart disease and rhythm disorders]. | measured in 119 patients with chronic heart disease (exercise-induced angina in 62, cardiosclerosis in 57 cases) presenting with arrhythmias (extrasystolic arrhythmia, permanent form cardiac fibrillation, association of cardiac fibrillation with ventricular arrhythmia, with n = 58, 38, 23 respectively) were blood levels of thyroid-stimulating hormone (tsh), triiodothyronine (t3) and thyroxin (t4) using immunoradiometric assay. in extrasystolic arrhythmia, permanent form cardiac fibrillation, the ... | 1998 | 9621622 |
| effect of protein and protein-free energy intake on plasma concentrations of insulin-like growth factor i and thyroid hormones in preruminant calves. | we conducted two experiments with preruminant calves weighing 80 to 240 kg to study the long-term nutritional regulation of circulating igf-i, thyroxine (t4), and triiodothyronine (t3). the two experiments were similar in design but were performed with calves of two live weight ranges: 80 to 160 kg (exp. 1) and 160 to 240 kg (exp. 2). in each experiment, 36 calves were allocated to one of 12 dietary treatments, which consisted of six protein intake levels at each of two energy intake levels. dig ... | 1998 | 9621941 |
| spuriously high free thyroxine with the access free t4 assay. | 1998 | 9622776 | |
| [diagnosis of bronchial carcinoma]. | in addition to conventional chest x-rays in ap and lateral projection, computed tomography of the chest, upper abdomen, and head, precutaneous ultrasonography of the abdomen, and bone scintigraphy represent the standard procedures for the primary diagnosis and staging of bronchial carcinoma. magnetic resonance imaging should be reserved for special situations and patients with allergy to i.v. contrast medium. the clinical value of positron emission tomography (pet) primarily with respect to lymp ... | 1998 | 9622819 |
| [urothelial carcinoma of the upper urinary tract. survival and prognostic factors]. | to analyze the survival and the main prognostic factors in patients with transitional cell carcinoma of the upper urinary tract. | 1998 | 9622915 |
| [dysphagia as a symptom of myxedema]. | we present a 79 year old female patient with dysphagia since two years. she showed also a lack of initiation and dysphonia. in the region of the larynx an edema was found and the tongue was hypertrophied. the x-ray examination demonstrated a dilated esophagus without impairment of the passage way. esophagoscopy showed also important edema in the hypopharynx and the entry into the esophagus. the tsh-0 was 74.45 mmu/l, the t3 0.23 and the t4 was 24 nmol/l. scintigraphically an only cherry-stone sm ... | 1998 | 9623334 |
| double-blind comparison of extradural block with three bupivacaine-ketamine mixtures in knee arthroplasty. | we have compared 0.5% bupivacaine 75 mg (group a; n = 15) with three 0.5% bupivacaine 75 mg-ketamine mixtures for extradural block in 59 asa i-iii patients undergoing total knee replacement in a randomized, double-blind study. the following doses of preservative-free 1% ketamine were used: 0.3 mg kg-1 (group b: n = 14); 0.5 mg kg-1 (group c: n = 5); and 0.67 mg kg-1 (group d: n = 15). level of sensory block, degree of motor weakness and sedation scores were recorded before and after operation. d ... | 1998 | 9623427 |
| insulin-like growth factor-binding protein-3 (igfbp-3) but not insulin-like growth factor-i (igf-i) remains elevated in euthyroid tsh-suppressed graves' disease. | thyroid hormones have been shown to be involved in the regulation of insulin-like growth factor-i (igf-i) and igf binding protein-3 (igfbp-3) expression. this is a cross-sectional study to look at the effects of thyroid hormone status on the circulating levels of igf-i and igfbp-3 in a group of 127 patients, aged 20-80 years, who were hyperthyroid, hypothyroid, rendered euthyroid and clinically euthyroid with normal free thyroxine (ft4), but suppressed thyroid stimulating hormone (tsh) levels. t ... | 1998 | 9623636 |
| the effects of thyroid status on serum apolipoprotein a-i-containing lipoprotein particles. | alterations of lipid profile are a well-known phenomenon in thyroid dysfunction. however, little is known about the influence of thyroid hormone on lp a-i and lpa-i:a-ii particles. we have, therefore, studied lpa-i and lpai:a-ii concentrations in a group of 20 patients with hyperthyroidism and in a group of 15 patients with hypothyroidism before and one month after attainment of euthyroidism. in hypothyroid patients, ldl-cholesterol and apo b concentrations decrease significantly after l-t4 repl ... | 1998 | 9623637 |
| preliminary results of bladder preservation by concurrent intraarterial chemotherapy and radiotherapy for muscle-invasive bladder cancer. | we previously reported favorable results of intraarterial doxorubicin chemotherapy in combination with low-dose radiotherapy for locally-advanced bladder cancer. we have now designed a new intraarterial chemotherapy regimen to achieve a higher tumor response rate while preserving a functional bladder. | 1998 | 9624552 |
| neuropsychological impairment and altered thyroid hormone levels in epilepsy. | neuropsychological impairment is a common problem in epilepsy which interferes with the quality of life of patients. similarly, thyroid hormone levels have been observed to be abnormal in patients with epilepsy on various treatments. this study aimed to ascertain any possible correlation between neuropsychological performance and thyroid hormone levels among epilepsy patients. | 1998 | 9624864 |
| occult papillary thyroid carcinoma in hashimoto's thyroiditis presenting as a metastatic bone tumor. | some occult thyroid carcinomas are hypothesized to regress and be eventually obliterated. we report here a patient whose condition supports this hypothesis. a 51-year-old male with primary hypothyroidism due to hashimoto's thyroiditis suffered from a rib bone tumor. he had a diffuse goiter with no nodular lesion. serum ft4 and tsh concentrations were 0.8 ng/dl and 36.4 microu/ml on taking 100 microg/day of t4. anti-tg- and -tpo-ab were strongly positive (99 and 1380 u/ml). the iodine 123 scintig ... | 1998 | 9625454 |
| 99tc(m)-mibi scanning of the thyroid gland in patients with markedly decreased pertechnetate uptake. | diffusely reduced 99tc(m)-pertechnetate uptake is a relatively infrequent but annoying finding that impairs evaluation of the thyroid gland. we studied 32 female patients aged 19-85 years with markedly reduced pertechnetate uptake. the following causes of reduced pertechnetate uptake were recognized: treatment with iodinated pharmaceuticals (n = 15), suppression therapy with t4 (n = 11), subacute thyroiditis (n = 5) and massive tumour replacement (n = 1). 99tc(m)-mibi thyroid scintigraphy was pe ... | 1998 | 9625501 |
| quantitation of amyloid beta-protein (a beta) in the cortex during aging and in alzheimer's disease. | in this study we sought to learn about when and how amyloid beta-protein (a beta) accumulates in the cortex of normal individuals and about the difference in the a beta accumulation between normal aged and alzheimer's disease (ad) brains. from consecutive autopsy cases and ad cases, hippocampus ca1 and occipitotemporal cortex t4 were sampled for a beta quantitation by the well characterized two-site enzyme immunoassays (eias). there was a strong tendency toward a beta 42 accumulation between the ... | 1998 | 9626067 |
| intense sympathetic nerve activity in adults with hypopituitarism and untreated growth hormone deficiency. | perturbations in the sympathetic nervous system may be anticipated in adults with hypopituitarism and untreated gh deficiency, because the syndrome is associated with both peripheral and central factors known to modulate sympathetic traffic. the higher prevalence of hypertension and increased cardiovascular morbidity/mortality reported in gh-deficient patients may suggest increased activity of the sympathetic nervous system. we recorded muscle sympathetic nerve activity (msna) in 10 hypopituitar ... | 1998 | 9626113 |
| fractionated high-dose-rate brachytherapy in primary carcinoma of the nasopharynx. | a growing body of data suggests that local control in nasopharyngeal cancer (npc) is related to the radiation dose administered. we conducted a single-institution study of high-dose radiotherapy (rt), which incorporated high-dose-rate (hdr) brachytherapy (bt). these results were analyzed together with data obtained from controls who did not receive bt. | 1998 | 9626223 |
| thyroxine-induced production of superoxide anion by human alveolar neutrophils and macrophages: a possible mechanism for the exacerbation of bronchial asthma with the development of hyperthyroidism. | bronchial asthma worsens after the development of hyperthyroidism. however, the biochemical mechanism of this phenomenon, which is induced by thyroxine (t4), remains obscure. in the present study, we showed that t4 directly stimulates production of superoxide anion by alveolar neutrophils and macrophages. these cells, when sensitized with a patient's serum and then treated with both the patient's specific allergen and t4, produced higher amounts of superoxide anion than did sensitized cells trea ... | 1998 | 9627810 |
| phage t4 dna [n6-adenine] methyltransferase: kinetic studies using oligonucleotides containing native or modified recognition sites. | the dna-[n6-adenine] methyltransferase of t4 phage (t4 dam mtase) catalyzes methyl group transfer from s-adenosyl-l-methionine (adomet) to the n6-position of adenine in the palindromic sequence, gatc. we have investigated the effect of eliminating different structural components of the recognition site on the ability of a substrate to be bound and methylated by t4 dam. for this purpose, steady state binding (by gel shift assays) and kinetic parameters of methylation (using the methyl donor, [3h- ... | 1998 | 9628341 |
| time-course of interleukin-2 receptor expression in interferon beta-treated multiple sclerosis patients. | the time-course of cd25 (the 55-kd/alpha subunit of the interleukin-2 (il-2) receptor) expression on cd4+ t lymphocytes, and serum levels of soluble il-2 receptors (sil-2r) and il-2 were evaluated in relapsing-remitting multiple sclerosis (rrms) patients treated with interferon beta-1b (ifnbeta1b). peripheral blood samples were collected before therapy (t0), and 1 (t1), 2 (t2), 3 (t3), 6 (t4), and 12 (t5) months after therapy initiation. while at t1 and t2, half the patients showed an increased ... | 1998 | 9628465 |
| chemical and enzymatic properties of bridging 5'-s-phosphorothioester linkages in dna. | we describe physicochemical and enzymatic properties of 5' bridging phosphorothioester linkages at specific sites in dna oligonucleotides. the susceptibility to hydrolysis at various ph values is examined and no measurable hydrolysis is observed at ph 5-9 after 4 days at 25 degrees c. the abilities of three 3'- and 5'-exonuclease enzymes to hydrolyze the dna past this linkage are examined and it is found that the linkage causes significant pauses at the sulfur linkage for t4 dna polymerase and c ... | 1998 | 9628913 |
| [iatrogenic hyperthyroidism secondary to weight loss medication. predictive factors for their precocious detention]. | to establish the differential clinical characteristics between the iatrogenic hyperthyroidism for not conventional medication for obesity treatment (weight losers) and the endogenous by graves basedow disease. | 1998 | 9629770 |
| iodine status, thyroid function and pregnancy: study of swedish and sudanese women. | to examine and compare the effects of pregnancy on the thyroid hormone homeostasis in two different populations with variable iodine supply. | 1998 | 9630385 |
| relationship between spine bone mineral density and vertebral body heights. | the aim of this study was to investigate the correlation between lumbar spine bone mineral density (ls-bmd) and the vertebral body heights with advancing age and years since menopause. one hundred and sixty-three women ages 39-74 years (77 normal premenopausal, ages 39-54, and 86 normal postmenopausal, ages 46-74 years) were studied. ls-bmd was measured by dual energy x-ray absorptiometry. vertebral heights were evaluated, using morphometry, as the sum of anterior (ahs), middle (mhs), and poster ... | 1998 | 9576974 |
| contemporary hormonal management of advanced prostate cancer. | the traditional definition of "advanced" prostate cancer includes only patients with widespread osteoblastic or soft-tissue metastases (clinical or pathologic stage t any n any m1; or stage d2). current evidence indicates that this definition should be broadened. because many patients with t3 disease or local lymph node metastases progress to distant metastases, the concept of advanced prostate cancer should also include stages c and d1 (t3, t4, and any t n1). furthermore, based on pretreatment ... | 1998 | 9575524 |
| late components of the event-related potentials and their topography in parkinson's disease. | late components of the event-related potential (erp; n100, p200, n200, and p300) were elicited using an auditory oddball paradigm (with a button-press response to target stimuli) in 15 parkinson's disease (pd) patients and 50 normal control subjects. compared with control subjects, pd subjects showed a significant decrease in n200 amplitude. between-group topographical differences in n200 amplitude were evident at central (c3, cz, c4) and temporal (t5, t3, t4, t6) regions. the results may reflec ... | 1998 | 9539339 |
| neoadjuvant concurrent chemoradiotherapy followed by definitive high-dose radiotherapy or surgery for operable thoracic esophageal carcinoma. | a prospective clinical trial was undertaken to investigate the feasibility of concurrent chemoradiotherapy for esophageal carcinomas. | 1998 | 9539559 |
| context-dependent protein stabilization by methionine-to-leucine substitution shown in t4 lysozyme. | the substitution of methionines with leucines within the interior of a protein is expected to increase stability both because of a more favorable solvent transfer term as well as the reduced entropic cost of holding a leucine side chain in a defined position. together, these two terms are expected to contribute about 1.4 kcal/mol to protein stability for each met --> leu substitution when fully buried. at the same time, this expected beneficial effect may be offset by steric factors due to diffe ... | 1998 | 9541409 |
| accuracy of computed tomography in determining resectability for locally advanced primary or recurrent colorectal cancers. | to determine the accuracy of computed axial tomography (ct) in determining tumor resectability in patients with locally advanced primary (t4) or locally recurrent colorectal cancer. | 1998 | 9568652 |
| genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor. | the generation of abs recognizing the native structure of the human thyrotropin receptor (htshr) has been difficult because there is currently no method allowing the purification of correctly folded ag in the amounts required by classical immunization protocols. the majority of abs made against the htshr react preferentially with denatured molecules. we report that a humoral response against the native htshr, compatible with mab production, is elicited in mice by immunization with a dna construc ... | 1998 | 9570567 |
| a comparative study of low-dose hyperbaric spinal lidocaine 0.5% versus 5% for continuous spinal anesthesia. | concerns of cauda equina syndrome have discouraged clinicians to use 5% lidocaine for continuous spinal anesthesia. earlier reports indicated that single-shot spinal lidocaine 0.5% is effective for minor gynecologic and perianal surgery. in the present study, we evaluate the anesthetic and hemodynamic effects of low dose hyperbaric 0.5% lidocaine for continuous spinal anesthesia and compare with those of the 5% lidocaine solution in patients undergoing urologic surgery. | 1998 | 9570605 |
| spinal anesthesia with tetracaine in 0.75% glucose: influence of the vertebral interspace used for injection. | the anesthetic behavior and hemodynamic consequences of spinal anesthesia with marginally hyperbaric tetracaine containing a low concentration of glucose injected at two different interspaces were examined and compared with those of conventionally hyperbaric solution. | 1998 | 9570606 |
| implications of cartilage invasion in surgically treated laryngeal carcinoma. | cartilage invasion adversely affects the outcome of laryngeal carcinoma treated with radiotherapy. the uicc and american joint committee on cancer (ajcc) classify laryngeal carcinoma with cartilage invasion as t4 or stage iv. | 1998 | 9570622 |
| studies of the anatomy and pathology of the orbit in carcinoma of the maxillary sinus and their impact on preservation of the eye in maxillectomy. | the periorbita has been traditionally regarded as the decisive layer whose involvement in carcinoma of maxillary sinus indicates orbital exenteration. anatomic texts depict that the orbital fat rests on the periorbita. our experience at surgical dissections has been different. | 1998 | 9570623 |
| is triiodothyronine capable of ameliorating pyrethroid-induced thyroid dysfunction and lipid peroxidation? | a study on the effect of triiodothyronine (t3) in the regulation of pyrethroid (fenvalerate)-induced thyroid dysfunction and lipid peroxidation was carried out in male mice. fenvalerate (120 mg kg(-1) body wt. daily for 15 days) administration led to a decrease in the serum concentration of thyroid hormones and the activity of hepatic type i iodothyronine 5'-monodeiodinase (5'd-i) and an increase in the level of lipid peroxidation. the decrease in the activity of hepatic 5'd-i due to the adminis ... | 1998 | 9570695 |
| effect of accessory proteins on t4 dna polymerase replication fidelity. | the influence of replication accessory proteins on the fidelity of t4 dna polymerase has been examined. steady-state kinetic measurements showed that exonuclease-deficient t4 dna polymerase, alone or with clamp loaders gp44/gp62 and polymerase clamp gp45, displays decreased binding affinity for incorrect as compared to correct dntps and a deceased kcat for misinsertion as compared to correct insertion. kinetic constants were similar with and without accessory proteins, indicating that accessory ... | 1998 | 9571039 |
| treatment of refractory depression with high-dose thyroxine. | in an open clinical trial we investigated whether addition of supraphysiological doses of thyroxine (t4) to conventional antidepressant drugs has an antidepressant effect in therapy-resistant depressed patients. seventeen severely ill, therapy-resistant, euthyroid patients with major depression (12 bipolar, five unipolar) were studied. the patients had been depressed for a mean of 11.5 +/- 13.8 months, despite treatment with antidepressants and, in most cases, augmentation with lithium, carbamaz ... | 1998 | 9571653 |
| relationship between psychotropic drugs and thyroid function: a review. | some widely used psychoactive drugs, such as tricyclic antidepressants and antipsychotic phenothiazines exhibit iatrogenic effects on the thyroid. these side effects may arise from interactions at different steps of thyroid hormone biosynthesis. these drugs can induce a change in iodine capture by thyroid cells or can complex iodine, making it unavailable for thyroid hormone synthesis and thus decreasing thyroid hormone blood levels; they can also inhibit thyroid peroxidase activity and thus t3 ... | 1998 | 9571980 |
| treatment of anal canal carcinoma with high dose radiation therapy and concomitant fluorouracil-cisplatinum. long-term results in 95 patients. | to evaluate the long-term results of the treatment of anal canal carcinoma (acc) with a combined concomitant radiochemotherapy (ccrt) treatment using fluorouracil (5 fu) and cisplatinum (cddp) with a high dose of radiation therapy. | 1998 | 9572617 |
| a ribosomal function is necessary for efficient splicing of the t4 phage thymidylate synthase intron in vivo. | splicing of the group i intron of the t4 thymidylate synthase (td) gene was uncoupled from translation by introducing stop codons in the upstream exon. this resulted in severe splicing deficiency in vivo. overexpression of a uga suppressor trna partially rescued splicing, suggesting that this in vitro self-splicing intron requires translation for splicing in vivo. inhibition of translation by the antibiotics chloramphenicol and spectinomycin also resulted in splicing deficiency. ribosomal protei ... | 1998 | 9573049 |
| plasma dopamine concentration and effects of low dopamine doses on urinary output after major vascular surgery. | to evaluate plasma dopamine concentration and the effects of low doses infusion on urinary output after abdominal vascular surgery in patients with renal function impairment we performed a prospective clinical study. twenty hemodynamically stable patients (mean age 66.6 years), with serum creatinine concentration < 2 mg %, who undergoing general anesthesia for major vascular surgery participated. a low dose of dopamine (3 micrograms/kg/min) was administrated to patients with postoperative protra ... | 1998 | 9573579 |
| [results of treatment of graves-basedow disease with 131i at low calculated doses]. | to evaluate the results of treatment of graves' disease with 131i at low calculated doses. | 1998 | 9558917 |
| thyroid function in acute pancreatitis. | to analyze changes in the thyroid function in patients with acute pancreatitis. | 1998 | 9558943 |
| [psychiatric manifestations as the only clinical sign of hypothyroidism. apropos of a case]. | this article intends to demonstrate, by presenting a clinical case, the importance of the thyroid examination in psychiatric practice. after a brief presentation of the evolution of the conceptions regarding the relation between thyroid insufficiency and psychiatric pathology, a clinical case is reported. this 63 years old man was admitted in a psychiatric ward because of his persecutive delusions and behavioral disorders (agitation, agressivity). cognitive (namely memory) impairment was also pr ... | 1998 | 9559307 |
| impaired interleukin-12 production is associated with a defective anti-tumor response in colorectal cancer. | despite development of many chemotherapeutic regimens, colorectal cancer continues to have a high mortality. one of the major new potential therapies is interleukin-12, a heterodimeric cytokine produced by antigen presenting cells. in vitro and in vivo studies have demonstrated the role of interleukin-12 in stimulating a cell-mediated anti-tumor response against a number of colon adenocarcinoma tumor models. however, it is unknown whether patients with colorectal cancer have impaired interleukin ... | 1998 | 9559630 |
| a species barrier between bacteriophages t2 and t4: exclusion, join-copy and join-cut-copy recombination and mutagenesis in the dctpase genes. | bacteriophage t2 alleles are excluded in crosses between t2 and t4 because of genetic isolation between these two virus species. the severity of exclusion varies in different genes, with gene 56, encoding an essential dct(d)pase/dut(d)pase of these phages, being most strongly affected. to investigate reasons for such strong exclusion, we have (1) sequenced the t2 gene 56 and an adjacent region, (2) compared the sequence with the corresponding t4 dna, (3) constructed chimeric phages in which t2 a ... | 1998 | 9560366 |
| dna polymerase fidelity: from genetics toward a biochemical understanding. | this review summarizes mutagenesis studies, emphasizing the use of bacteriophage t4 mutator and antimutator strains. early genetic studies on t4 identified mutator and antimutator variants of dna polymerase that, in turn, stimulated the development of model systems for the study of dna polymerase fidelity in vitro. later enzymatic studies using purified t4 mutator and antimutator polymerases were essential in elucidating mechanisms of base selection and exonuclease proofreading. in both cases, t ... | 1998 | 9560367 |
| a new look at old mutants of t4 dna polymerase. | 1998 | 9560372 | |
| the roles of the bacteriophage t4 r genes in lysis inhibition and fine-structure genetics: a new perspective. | seldom has the study of a set of genes contributed more to our understanding of molecular genetics than has the characterization of the rapid-lysis genes of bacteriophage t4. for example, t4 rii mutants were used to define gene structure and mutagen effects at the molecular level and to help unravel the genetic code. the large-plaque morphology of these mutants reflects a block in expressing lysis inhibition (lin), the ability to delay lysis for several hours in response to sensing external rela ... | 1998 | 9560373 |
| regulation of dna polymerase exonucleolytic proofreading activity: studies of bacteriophage t4 "antimutator" dna polymerases. | 1998 | 9560374 | |
| antimutator mutants in bacteriophage t4 and escherichia coli. | antimutators are mutant strains that have reduced mutation rates compared to the corresponding wild-type strain. their existence, along with mutator mutants that have higher mutation rates compared to the wild-type strain, are powerful evidence that mutation rates are genetically controlled. compared to mutator mutants, antimutators have a very distinguishing property. because they prevent normally occurring mutations, they, uniquely, are capable of providing insight into the mechanisms of spont ... | 1998 | 9560377 |
| aspects of the ultraviolet photobiology of some t-even bacteriophages. | bacteriophage t4 dna metabolism is largely insulated from that of its host, although some host functions assist in the repair of t4 dna damage. environmental factors sometimes affect survival and mutagenesis after ultraviolet (uv) irradiation of t4, and can affect mutagenesis in many organisms. we therefore tested the effect of certain environmental factors and host genetic defects upon spontaneous and uv-induced mutagenesis and survival in t4 and some related t-even phages. plating at ph 9 enha ... | 1998 | 9560380 |
| the spectrum of acridine resistant mutants of bacteriophage t4 reveals cryptic effects of the tsl141 dna polymerase allele on spontaneous mutagenesis. | mutations in the ac gene of bacteriophage t4 confer resistance to acridine-inhibition of phage development. previous studies had localized the ac gene region; we show that inactivation of t4 open reading frame 52.2 confers the acr phenotype. thus, 52.2 is ac. the resistance mechanism is unknown. the ac gene provides a convenient forward mutagenesis assay. its compact size (156 bp) simplifies mutant sequencing and diverse mutant types are found: base substitutions leading to missense or nonsense ... | 1998 | 9560385 |
| effects of thyroidectomy or thiouracil treatment on copulatory behavior in adult male rats. | male copulatory behavior and the function of the hypothalamo-hypophysial-gonadal axis in hypothyroid male rats were investigated in the present study. hypothyroidism was induced by thyroidectomy or thiouracil. in male copulatory behavior test, intromission latencies in hypothyroid rats were significantly longer than those in euthyroid rats and ejaculation frequencies were reduced in hypothyroid male rats compared to control rats without reduction of plasma concentrations of testosterone. these c ... | 1998 | 9560772 |
| bone mineral density and menstrual irregularities. a comparative study on cortical and trabecular bone structures in runners with alleged normal eating behavior. | bone mineral density (bmd), and associated biochemical and endocrine markers were compared in a group of runners with menstrual dysfunction (ir, n=13), and a group of performance matched eumenorrheic runners (r, n=15). all subjects claimed to have normal eating habits. body height and weight, body mass index, and amount of body fat were similar. the ir group consisted of 5 presently oligomenorrheic (o) and 8 presently amenorrheic (a) runners. the bmd values of the athletes were additionally comp ... | 1998 | 9562216 |
| production of trophoblastic hormones by transitional cell carcinoma of the bladder: association to tumor stage and grade. | cancer registration statistics of economically advanced countries indicate that bladder carcinoma incidence ranks fourth in men and eighth in women, but a reliable tumor marker for predicting the disease course is still lacking. we designed an immunohistochemical study to comprehensively assess the trophoblastic hormone production profile of transitional cell carcinoma (tcc) of the bladder. moreover, we correlated histological differentiation and tumor stages with marker expression and, finally, ... | 1998 | 9563788 |