Publications

the effects of soybean diet on thyroid hormone and thyrotropin levels in aging rats.	objective: to estimate the effect of soybean diet on serum level of thyroid hormone, its metabolites and thyrotropin (tsh) during aging in rats. methods: male donryu rats were fed laboratory chow containing 40 (group a) or 10 volume percent (group b) soybean protein, while controls (group c) received regular laboratory chow. groups of 10 animals of each groups were sacrificed by decapitation at the age of 12, 18, 24 and 30 months. serum total thyroxine (t4), free thyroxine (ft4), 3,5,3'-triiodot ...	1998	10200590
spontaneous hyperthyroidism in an aged male and female macaca mulatta.	a 31-year-old male and a 31-year-old female rhesus monkey developed clinical signs consistent with hyperthryoidism. these included a ravenous appetite, hyperactivity, and accentuated ratchet movement and hand tremors while performing fine motor tasks. bilaterally enlarged thyroid glands were palpated in both monkeys. a unique clinical finding of the female as the hypertrophic cardiomyopathy. the t3 and t4 levels in the male rhesus were 3.79 ng/ml and 28.20 microg/dl, respectively. t3 and t4 leve ...	1998	10203006
the igf-i response to very low rhgh doses is preserved in human ageing.	the activity of the gh/igf-i axis varies during life and is clearly reduced in the elderly. in fact, gh, igf-i and igfbp-3 levels in older people are clearly reduced and similar to those observed in patients with gh deficiency. the declining activity of the gh/igf-i axis with advancing age may contribute to changes in body composition, structure, function and metabolism. in fact, treatment with pharmacological doses of rhgh restored plasma igf-i levels, increased lean body mass and muscle streng ...	1998	10209563
secondary adrenal insufficiency associated with autoimmune disorders: a report of twenty-five cases.	addison's disease is frequently a component of autoimmune polyendocrinopathies while secondary adrenal insufficiency associated with autoimmune disorders is believed to be a rare event. we present a series of patients with secondary adrenal insufficiency coexisting with autoimmune diseases and/or antithyroid autoantibodies.	1998	10209566
immunological and endocrinological disturbances in patients after prolonged coma following head injury.	it has been previously reported that following severe brain damage, a deficit of cellular immunity could be detected in the early phase after the occurence of the lesion. we report here the results of a cross-sectional study on long term effects of severe brain damage on immunological and neuro-endocrine changes in patients who recovered from prolonged coma caused by head injury. results obtained from post-comatose (pc) patients were compared with those obtained from two control groups made up o ...	1998	10210826
[comparative evaluation of triamcinolone in coccidiosis control in fattening chickens].	the effectiveness of triancinolone as a protector against coccidiosis in broilers was tested in a random design experiment. cobb x cobb one-day old chicken were assigned to the treatments: t1: no medication-no inoculation; t2: no medication-inoculation; t3: triancinolone-inoculation; t4: sodic monensin-inoculation; and t5: sodic salinomycin-inoculation. the inoculation was accomplished with 10,000 oocysts of eimeria tenella and 40,000 of intestinal eimerias. the results of the intestinal damage ...	1998	10205918
[the influence of salmon calcitonin on changes in thyroid hormone concentration and on tsh secretion. i].	the aim of this investigation was determination of salmon calcitonin (sct) influence on changes of thyroid hormones levels in serum. the investigation was carried out on a group of 26 patients. the group was divided in two different ways: into people younger and older than 65 years, and into men and women. investigation protocol consists of 4 days. on the 1st day patients received 100u of sc, on the 2nd day--100u of sc and 0.4 mg trh, on the 3rd day--0.4 mg trh, on the 4th day--0.9% solution of ...	1998	10335024
[the effect of the patient's hormonal status on the outcome of an operation for stomach cancer].	the comparative analysis of the blood serum contents of triiodthyronine (t3), thyroxin (t4), hydrocortisone, prolactin and insulin in 59 survived and in 13 dead patients with gastric cancer was conducted. the prognostical significance of hormonal stress disorders was revealed. the prognosis for gastric cancer patients while the anabolic processes suppression is nonfavourable.	1998	10077922
[endosonographic staging of rectal tumors in a surgical department].	in 1997 and 1998 the authors implemented and evaluated endosonographic examinations of the rectum in 34 patients, incl. 22 on account of carcinoma and 12 for adenoma. carcinomas classification t1 were recorded in 9%, t2 in 27.3%, t3 in 54.5% and t4 in 9%. agreement with histopathological staging was recorded in 63.6%. in adenomas in 17% a suspect malignant appearance and spread into the muscularis propria was found and this was confirmed by histological examination. the results confirmed the con ...	1998	10081324
[iodine deficiency and pregnancy].	iodine availability for maternal thyroid during pregnancy results from a combination of specific factors (increased urinary iodine loss, fetal-placental unit competition) and is critically reduced by the nutritional deficiency. hyperestrogenism is associated with increased circulating thyroxine-binding globulin (tbg) levels and a higher binding capacity for t4 and t3, because of a reduced clearance rate of the protein. our study carried out in a moderately iodine deficiency area from north-easte ...	1998	10052168
[recurrence of stomach cancer following surgery].	the purpose of this article is to review the incidence and characteristic of first recurrence in a group of 182 patients who underwent curative surgery with extended lymphadenectomy (> or = d2). the median follow up was 46.4 months (range 14-111). the incidence of relapses was 3.3% in the early gastric cancer and 50.8% in the advanced cancer. first recurrence site was systemic in 69.4% of cases and locoregional in 22.6%. the major site of systemic recurrences were peritoneal surface (64.8%), liv ...	1998	10052210
early cancer in achalasia.	esophagus achalasia is considered by many authors a preneoplasic disease and, for this reason, they propose a follow-up with endoscopies and brush cytology. for others, the possibility of cancer in achalasia is very low and the surveillance is not justified owing to its fallibility and high cost. generally, cancer in achalasia has a late diagnosis as a consequence of megaesophagus and of many years of symptoms attributed to achalasia disease. the rate of resectability is low and 5-year survival ...	1998	10071806
effect of propylthiouracil induced hypothyroidism in developing rat cerebellum: comparison of cerebellar parameters in five day old normal and treated rat pups.	the effect of pre and postnatal hypothyroid environment on the development of cerebellum in the rat pups was determined. four groups of rat dams, namely control, group i, ii and iii were treated with propylthiouracil (ptu) in water for different length of time during pregnancy and nursing periods. the pups born from these dam groups were subsequently named after the corresponding dam group, namely control, group i, ii and iii. general quantitative results showed that pups from the treated dams h ...	1998	10065197
in vitro repair synthesis of bcnu-induced dna damage.	the nitrosoureas including bcnu are potent chemotherapeutic drugs and have been used extensively for treatment of brain tumors and other neoplasias but the mechanisms of action for the dna lesions created and their repair are still unclear. we have recently determined the in vitro repair of bcnu-treated dna with cellular extracts and with dna modifying enzymes. bcnu not only caused an increase in breaks in plasmid dna, but an increase in cross-linked dna was also observed after restriction enzym ...	1998	10072211
effects of thyroid hormones on myofibrillar proteolysis and activities of calpain, proteasome, and cathepsin in primary cultured chick muscle cells.	the effects of thyroxine (t4) and triiodothyronine (t3) on growth, muscle protein degradation, and proteases activities in cultured chick muscle cells were studied. the cells were treated with a physiological level of t4 (60 ng/ml) or t3 (12 ng/ml) for 6 d. calpain, cathepsins, and proteasome activities and n tau-methylhistidine release were measured as indexes of myofibrillar protein breakdown. creatine kinase activity was also measured as an index of myotube formation. calpain activity was inc ...	1998	10197311
cost effectiveness of screening for subclinical hypothyroidism in the elderly. a decision-analytical model.	the value of early detection of subclinical hypothyroidism is the object of a long lasting debate. in this study, we assessed the cost effectiveness of a policy based upon screening for this condition through thyroid-stimulating hormone (tsh), triiodothyronine (t3) and thyroxine (t4) serum level measurements in the elderly.	1998	10186461
amphibian metamorphosis as a model for studying the developmental actions of thyroid hormone.	a salient feature of the thyroid hormones. l-thyroxine (t4) and triiodo-l-thyronine (t3), is the multiplicity of their physiological and biochemical actions in a wide variety of vertebrates. important among these is their profound effects on postembryonic development. analysis of their developmental action in mammals is vitiated by the exposure of the developing foetus to a number of maternal factors which do not allow one to specifically define the role of thyroid hormone (th) or that of other ...	1998	10189985
final height and endocrine function in thalassaemia intermedia.	we present data of a detailed study of endocrine function in 50 patients (21 males, 29 females) with thalassaemia intermedia, 15-46 years old (mean age 28.7 yr), with raised serum ferritin levels (mean 1540 micrograms/l). mean haemoglobin concentration was 8.1 g/dl. half of them had had more than 50 transfusions in their life and had received irregular intramuscular or subcutaneous chelation therapy. delayed puberty was one of the most frequent (36%) clinical endocrine abnormalities found in our ...	1998	10091174
seasonal variation of serum tsh and thyroid hormones in males living in subarctic environmental conditions.	to evaluate the seasonal influence upon thyroid hormone dynamics, we took blood samples every two months during a period of 14 months from 20 healthy males living in northern finland (69-70 degrees n), where the mean daily temperature ranges from a winter minimum of -40 degrees c to a summer maximum of 2 degrees c, while the photoperiod changes from a polar night of 6 days in winter to a polar day of 45 days in summer. the subjects were allowed free choice of diet, exercise, and outdoor exposure ...	1998	10093311
the prevalence of goitre and cretinism in a population of the west ivory coast.	iodine deficiency is a major public health problem in developing countries. the main areas where goitre is prevalent have been identified, but the different degrees of severity and the populations affected have not. most countries are now attempting to obtain reliable and more extensive data. a pilot study was carried out in the ivory coast in order to improve epidemiological knowledge of iodine deficiency and collect the information required to set up an elimination programme. the aim of this s ...	1998	10097418
activity losses among t4 lysozyme variants after adsorption to colloidal silica.	maintaining a specific molecular conformation is essential for the proper functioning of an enzyme. a substantial loss of catalytic activity can occur from the displacement caused by even a single amino acid substitution. activity may also be lost as an enzyme undergoes a conformational change during adsorption. in this study, we investigated the effect of thermostability on the activities of three t4 lysozyme variants after adsorption to 9 nm colloidal silica particles. less-stable t4 lysozyme ...	1998	10099305
contribution of protein charge to partitioning in aqueous two-phase systems.	protein partitioning in aqueous two-phase systems based on phase-forming polymers is strongly affected by the net charge of the protein, but a thermodynamic description of the charge effects has been hindered by conflicting results. many of the difficulties could be because of problems in isolating electrochemical effects from other interactions of phase components. we explored charge effects on protein partitioning in poly(ethylene glycol)-dextran two-phase systems by using two series of geneti ...	1998	10099360
evaluation and characterization of congenital hypothyroidism in rdw dwarf rats.	the rdw rat is a new strain of dwarf mutant that has decreased blood thyroxine (t4) and growth hormone (gh) concentrations and testicular enlargement during development and aging. to confirm whether this strain can be used as a new hypothyroid model, the experiments reported here were carried out, using adult rdw rats, rdw rats treated with thyroxine, and clinically normal (n) wistar-imamichi rats. clinical parameters of deficient thyroid function in rdw rats were chosen for evaluation and chara ...	1998	10090064
role of colestipol in the treatment of hyperthyroidism.	the enterohepatic circulation of thyroxine (t4) and triiodothyronine (t3) is higher in thyrotoxicosis. bile-salt sequestrants bind iodothyronines and thereby increase their fecal excretion. we, therefore, evaluated the effect of colestipol-hydrochloride administration on clinical and biochemical indices of patients with hyperthyroidism. in a prospective, controlled trial, ninety-two adult volunteers with graves' disease, toxic autonomous nodule or toxic multinodular goiter were randomly assigned ...	1998	9972670
characteristics of gene 28 product, the constituent of the central part of bacteriophage t4 baseplate.	the phage td gene 28 product has been partially characterized and its biological role has been examined. it was found to be a protein with a molecular size of 24 kda which cosediments with the membrane fraction of the bacterial extracts and could only be washed out by a 0.2% sarcosyl solution. other observations indicate that gp 28 has a majority of hydrophobic residues on its surface and forms a homotrimeric complex in the absence of other phage proteins. the product was finally identified as a ...	1998	9990707
bone changes in pre- and postmenopausal women with thyroid cancer on levothyroxine therapy: evolution of axial and appendicular bone mass.	the effects of suppressive doses of levothyroxine (lt4) on bone mass are controversial. our aim was to evaluate the effects on axial and appendicular bone mineral density (bmd) and bone metabolism of long-term lt4 suppressive therapy in women by means of cross-sectional and longitudinal studies, and also to assess the potential influence of menopausal status and lt4 dose. seventy-six women (aged 47 +/- 13 years, 37 pre- and 39 postmenopausal) on suppressive therapy (67 +/- 34 months duration, me ...	1998	10024900
measurement of serum tsh in the investigation of patients presenting with thyroid enlargement.	in otherwise euthyroid patients presenting with thyroid enlargement, reduction in serum thyrotrophin (tsh) concentrations measured in a sensitive assay may be a marker of thyroid autonomy and may therefore indicate a benign underlying pathology. we investigated prospectively a cohort of 467 subjects presenting consecutively to our thyroid clinic with nodular or diffuse enlargement of the thyroid. subjects were divided into those with normal (0.4-5.5 mu/l), low but detectable (0.1-0.39 mu/l) or u ...	1998	10024927
pcr-based approaches to adduct analysis.	ligation-mediated polymerase chain reaction (lmpcr) is a pcr-based method for the detection of dna adducts at individual nucleotide positions in mammalian genes. adduct-specific enzymes, such as t4 endonuclease v, various base excision repair enzymes, uvrabc nuclease, and chemical cleavage techniques can be used to convert the adducts into dna strand breaks. the positions of these breaks are then detected by lmpcr. this method has been used primarily to map the distribution of uv-induced dna les ...	1998	10022294
expression of alpha- and beta-subunits and activity of na+k+ atpase in pig thyroid cells in primary culture: modulation by thyrotropin and thyroid hormones.	na+ k+ atpase located at the basolateral pole of thyroid epithelial cells, contributes to thyroid hormone synthesis by generating the driving force for the uptake of the substrate, iodide. we have investigated whether the expression of the alpha- and beta-subunits and activity of na+ k+ atpase were subjected to variations in response, (a) to tsh, that controls the expression of differentiation in thyroid cells and (b) to thyroid hormones as potential autocrine factors. studies were carried out o ...	1998	10022767
evaluation of the tn sub-staging in patients with initially unresectable stage iii non-small cell lung cancer treated by induction chemotherapy. the european lung cancer working party.	this study attempted to investigate, in a cohort of patients with clinical stage iii initially unresectable non-small cell lung cancer (nsclc) treated by the same induction chemotherapy regimen, the prognostic value of clinical t and n sub-groupings in order to validate the current international staging system (iss).	1998	10048473
comparison of synonymous codon distribution patterns of bacteriophage and host genomes.	synonymous codon usage patterns of bacteriophage and host genomes were compared. two indexes, g + c base composition of a gene (fgc) and fraction of translationally optimal codons of the gene (fop), were used in the comparison. synonymous codon usage data of all the coding sequences on a genome are represented as a cloud of points in the plane of fop vs. fgc. the escherichia coli coding sequences appear to exhibit two phases, "rising" and "flat" phases. genes that are essential for survival and ...	1998	10048480
[recurrences after thyroid lobectomy for benign thyroid diseases: analysis of a clinical-instrumental follow up].	the authors propose to verify the therapeutical role of lobectomy in confronting monolobar nodular thyroid disease. in a period of 4 years (1990-1993), forty-four patients (30 women, 14 men) underwent thyroid lobectomy for a benign disease and follow-up treatment for 3 years on a semestral basis. all patient were studied both before the operation and during the follow-up using us and measuring the levels of t3, t4 and tsh; 34 patients (77.2%) had undergone a scintigraphy before surgery. the indi ...	1998	10052208
gfp:hiv-1 protease production and packaging with a t4 phage expression-packaging processing system.	a bacteriophage t4-derived protein expression, packaging and processing system was used to create recombinant phage that encode, produce and package a protein composed of human hiv-1 protease fused to green fluorescent protein (gfp). the fusion protein is targeted within the phage capsid by an n-terminal capsid targeting sequence (cts), which is cleaved through proteolysis by the viral scaffold protease p21. the fusion protein is designated cts [symbol see text] gfp:pr. the [symbol see text] sym ...	1998	9863054
predictive value of bcl-2 immunoreactivity in prostate cancer patients treated with radiotherapy.	recent experimental evidence suggests that overexpression of bcl-2, a protein functioning by blocking apoptosis, may influence the treatment outcome in human tumours, including prostate cancer. to test the clinical implications of this hypothesis, tumours from patients with prostate cancer treated with external beam radiotherapy were investigated for bcl-2 immunoreactivity (ir) and correlated with prognosis and treatment outcome.	1998	10052879
[olpadronate prevents cortical and trabecular bone loss induced by supraphysiological dosis of thyroxine in ovariectomized rats].	the aim of the present report was to clarify the effect of excess t4 on axial and peripheral bone mineral density (bmd) in estrogen-depleted rats. the protective effect of olpadronate (olpa) on axial and peripheral bone mass in thyroxine-treated rats was also investigated. female sprague-dawley rats were used: sham, ovx + vh, ovx + olpa (0.3 mg/kg/week), ovx + t4 (250 micrograms/kg/day) and ovx + t4 + olpa rats. ovx + vh group presented a bmd lower than sham in the tibia (p < 0.01) but not in fe ...	1998	9922475
improved nasal breathing in snorers increases nocturnal growth hormone secretion and serum concentrations of insulin-like growth factor 1 subsequently.	in snoring men improved nasal breathing during sleep has been shown to decrease snoring and morning tiredness. the aim was to evaluate whether improved nasal breathing had any effect on growth hormone (gh) secretion, the nocturnal secretion of gh being associated with deep sleep. forty-two snoring men, mean age 45 years and mean body mass index 26 kg.m-2, slept every night during one month with the nozovent nostril dilator. before and at the end of the test period, we analysed serum insulin-like ...	1998	9923061
performance, incidence of metabolic disturbances and endocrine variables of food-restricted male broiler chickens.	1. this experiment was carried out to evaluate the productive and physiological consequences of a slight but long term food restriction of male broiler chickens from 2 commercial strains. 2. cobb-500 and ross chickens were submitted to a 20% food restriction from 8 to 21 d of age. strain, food programme and their interactive effects were analysed in terms of consequences upon performance, mortality, incidence of sudden death syndrome (sds) and ascites syndrome (as), index of right cardiac hypert ...	1998	9925321
spinal anaesthesia for paediatric day-case surgery: a double-blind, randomized, parallel group, prospective comparison of isobaric and hyperbaric bupivacaine.	we have compared bupivacaine 5 mg ml-1, either isobaric in saline 0.9% or hyperbaric in 8% glucose, for spinal anaesthesia in 100 children, aged 2-115 months, in a double-blind, randomized, parallel group, prospective study. children were premedicated with diazepam 0.5 mg kg-1 orally. seventy-two children were sedated before, and 25 children after, lumbar puncture, with either propofol or thiopental (thiopentone). after lumbar puncture in the lateral decubitus position with a 24-27-gauge paediat ...	1998	9924220
epidural anaesthesia for caesarean section in an achondroplastic dwarf.	we describe the anaesthetic management of a parturient with achondroplasia presenting for caesarean section under epidural anaesthesia. a block extending from t4 to s4 was established over 25 min using a total of 12 ml of 2.0% lidocaine (lignocaine) with epinephrine (adrenaline) 1:200,000 and fentanyl 37.5 micrograms. apart from mild discomfort during peritoneal incision, her perioperative course was uneventful. achondroplasia is reviewed and the anaesthetic implications of the condition are dis ...	1998	9924247
[adjuvant chemoradiotherapy of cancers of the rectum].	increasing local control remains a major endpoint in the adjuvant setting of rectal cancer. postoperative concurrent 5fu-based chemotherapy and irradiation demonstrated its value in duke's b and c patients. toxicity decreased from the first studies to the current one's in relation with better radiotherapy technique, reduction of chemotherapy duration and quality assurance programs. because preoperative irradiation alone has demonstrated its value on local control and overall survival, preoperati ...	1998	9922776
recombination and recombination-dependent dna replication in bacteriophage t4.	general recombination is essential for growth of phage t4, because origin initiation of dna replication is inactivated during development, and recombination-dependent initiation is necessary for continuing dna replication. the requirement of recombination for t4 growth has apparently been a driving force to acquire and maintain multiple recombination mechanisms. this requirement makes this phage an excellent model to analyze several recombination mechanisms that appear redundant under optimal gr ...	1998	9928485
changes of leukocyte subsets in coronary artery bypass surgery: cardiopulmonary bypass versus 'off-pump' techniques.	the use of cardiopulmonary bypass (cpb) in coronary bypass grafting is associated with a generalized inflammatory response. this negative impact of cpb may be avoided by using new surgical techniques recently introduced to perform coronary bypass grafting 'off-pump', i.e. without cpb.	1998	9928852
[pelvic exenteration from the surgical viewpoint].	pelvic exenteration (pe) is associated with specific problems in the indication of excision and reconstructive surgery. indication are colorectal cancer or cervical cancer recurrence. in each case intensive and early cooperation of gynecologist, surgeon and urologist is warranted. thus, pe is indicated in some t3 n1 and t4 rectal carcinoma patients without distant metastases and may be superior to chemotherapy. in cervix carcinoma recurrence, pe with or without intestinal reconstruction is of sp ...	1998	9931619
[classification of ethmoid malignancies].	the uicc and ajcc never classified ethmoid malignancies prior to the latest edition (1997). most classifications in the literature refer to a single histological type (estensioneuroblastoma or carcinoma) while others basically consider the intracranial extension, without distinguishing between intra or extradural. still others consider invasion of the orbit. there is as yet no classification which considers all the prognostic factors associated with the extension of this neoplasm. the authors re ...	1998	9926446
[operation or intervention in advanced gallbladder carcinoma?].	in a retrospective study of patients with locally advanced or metastatic gallbladder cancer, we tried to define patient groups, that profit either from extended resection, palliative surgery or intervention. 102 out of 160 operative treated patients (73.8%) had uicc-tumor stages iii and iv. depending on the t-stage, resection rates were 31% for t3-stage and 12.5% for t4-stage tumors. corresponding median survival times were 20.2 and 18.1 month, respectively. patients with t3/t4-tumor stages, whe ...	1998	9931638
the effect of povidone-iodine on thyroid function of neonates with different birth sizes.	the aim of this study was to elucidate the role of povidone-iodine (pv-i) on thyroid function of newborns with different birth sizes in a high iodine-intake city. serial measurements of serum thyroxine (t4) and thyrotropin (tsh) levels were done in 44 newborns locally treated with 10% pv-i for insertion of percutaneous central venous catheters. the results showed that the thyroid function was influenced prominently in very-low-birth weight (vlbw) babies. tsh went significantly higher after appli ...	1998	9926509
[value of magnetic resonance tomography in preoperative staging of stomach carcinoma].	the value of mri as a preoperative staging procedure in stomach carcinomas compared to ct and endosonography was examined in a prospective study and correlated with the pathohistological results. mri showed better correlation with the pathohistological evaluation at the t3, t4, n and m stage than the other two test procedures. mri is thus a suitable staging procedure for stomach carcinomas.	1998	9931884
converting t4 phage lysozyme into a transglycosidase.		1998	9928113
thyrotropin secreting pituitary adenoma effectively treated with octreotide.	we report a 65-year-old woman with thyrotropin (tsh) secreting pituitary adenoma, who was diagnosed based on the lack of inhibition of serum tsh despite an increased serum free thyroxine (t4), a low response of serum tsh to thyrotropin releasing hormone, and a pituitary tumor as revealed by magnetic resonance imaging. the pituitary adenoma was, however, inoperable due to chronic respiratory failure. the treatment with octreotide in a dose of 100 microg b.i.d. resulted in inhibition of serum tsh ...	1998	9932634
radiation, hormonotherapy, survival and local control in prostatic carcinoma.	the combination of concomitant external beam radiotherapy (ert) and neoadjuvant hormonotherapy was shown to be able to significantly improve local control and disease-free survival in locally advanced prostatic carcinoma. (rtog study 8610). aim of this analysis was to assess the clinical results observed in a population of patients undergoing this combined treatment and, more particularly, to examine the prognostic impact of local control. 84 patients (t2: 47%, t3: 49.4%, t4: 3.6%) underwent con ...	1998	9932471
identification and structural characterization of a novel member of the vitamin d binding protein family.	the apparent high degree of homology of a blood protein with a unique dual binding affinity for two distinct hormones, thyroxin (t4) and vitamin d, isolated from a turtle, trachemys scripta (family emydidae) and mammalian vitamin d binding protein (dbp) prompted further interspecific comparison to better understand the structure of functional binding sites. using polymerase-chain reaction (pcr) with primers derived from the putative nucleotide sequences encoding peptides from the degradation of ...	1998	9972311
dual role of betel leaf extract on thyroid function in male mice.	the effects of betel leaf extract (0.10, 0.40, 0.80 and 2.0 g kg-1 day-1 for 15 days) on the alterations in thyroid hormone concentrations. lipid peroxidation (lpo) and on the activities of superoxide dismutase (sod) and catalase (cat) were investigated in male swiss mice. administration of betel leaf extract exhibited a dual role, depending on the different doses. while the lowest dose decreased thyroxine (t4) and increased serum triiodothyronine (t3) concentrations, reverse effects were observ ...	1998	9990660
higher thyroid hormone levels in neonatal life result in reduced testis volume in postpubertal bulls.	thyroid hormones appear to determine adult testis size in rodents by regulating the period of sertoli cell proliferation in the neonatal period. in the present study, the correlation between neonatal thyroid hormone levels (t3 and thyroxin, t4) and postpubertal testis size in simental bulls was examined. t3 and t4 levels were measured in blood plasma from 35 calves immediately after their arrival at the ai centre at age 3-6 months. testis size (height and width) was measured at 12 months of age ...	1998	9972493
preoperative chemoradiation for advanced vulvar cancer: a phase ii study of the gynecologic oncology group.	to determine the feasibility of using preoperative chemoradiotherapy to avert the need for more radical surgery for patients with t3 primary tumors, or the need for pelvic exenteration for patients with t4 primary tumors, not amenable to resection by standard radical vulvectomy.	1998	9747823
antibiotic inhibition of rna catalysis: neomycin b binds to the catalytic core of the td group i intron displacing essential metal ions.	the aminoglycoside antibiotic neomycin b induces misreading of the genetic code during translation and inhibits several ribozymes. the self-splicing group i intron derived from the t4 phage thymidylate synthase (td) gene is one of these. here we report how neomycin b binds to the intron rna inhibiting splicing in vitro. footprinting experiments identified two major regions of protection by neomycin b: one in the internal loop between the stems p4 and p5 and the other in the catalytic core close ...	1998	9737922
solution structure of a na cation stabilized dna quadruplex containing g.g.g.g and g.c.g.c tetrads formed by g-g-g-c repeats observed in adeno-associated viral dna.	we have applied nmr and molecular dynamics computations including intensity based refinement to define the structure of the d(g-g-g-c-t4-g-g-g-c) dodecanucleotide in 100 mm nacl solution. the g-g-g-c sequence is of interest since it has been found as tandem repeats in the dna sequence of human chromosome 19. the same g-g-g-c sequence is also seen as islands in adeno-associated virus, a human parvovirus, which is unique amongst eukaryotic dna viruses in its ability to integrate site-specifically ...	1998	9737926
a k cation-induced conformational switch within a loop spanning segment of a dna quadruplex containing g-g-g-c repeats.	we have identified a unique structural transition (in slow exchange on the nmr time scale) in the tertiary fold of the d(g-g-g-c-t4-g-g-g-c) quadruplex on proceeding from na+ to k+ as counterion in aqueous solution. both monovalent cation-dependent conformations exhibit certain common structural features, which include head-to-tail dimerization of two symmetry-related stem-hairpin loops, adjacent strands which are antiparallel to each other and adjacent stacked g(syn).g(anti). g(syn).g(anti) tet ...	1998	9737927
an apyrimidinic site kinks dna and triggers incision by endonuclease vii of phage t4.	apurinic/apyrimidinic lesions (ap-sites) occur frequently in dna, generated by physically and chemically induced or spontaneous loss of bases. repair mechanisms have evolved in organisms to deal efficiently with ap-sites by first incising the dna at the lesion, followed by excision and resynthesis of the damaged strand. here we report that endonuclease vii (endo vii) of phage t4, which was originally classified as a debranching and holliday structure resolving enzyme, also recognizes ap-sites wi ...	1998	9742246
tyrosine 130 is an important outer ring donor for thyroxine formation in thyroglobulin.	the thyroid couples two iodotyrosine molecules to produce thyroid hormone at the acceptor site in thyroglobulin, leaving dehydroalanine or pyruvate at the donor position. previous work has located the acceptors but not the principal iodotyrosine donors. we incorporated [14c]tyrosine into beef thyroid slices, isolated and iodinated the [14c]thyroglobulin (tg i), separated its n-terminal approximately 22-kda hormone-rich peptide, and digested the latter with trypsin and endoproteinase glu-c (ec 3. ...	1998	9737985
[brief preoperative radiotherapy in surgical therapy of rectal carcinoma. long-term results of a prospective randomized study].	to ascertain whether preoperative short-term radiotherapy can improve local tumor control and the long-term survival of patients with operable rectal cancer, a prospective randomised trial was performed from 1988 to 1993. ninety-three patients with rectal cancer were either directly treated with surgery (n = 46) or underwent preoperative radiotherapy with 5 x 3.3 gy irradiation and operation within 48 h (n = 47). if indicated (t4, uicc stage iii) patients also received postoperative irradiation. ...	1998	9738225
thyroid accumulation and adverse effects of imipramine and desipramine in rats after long-term administration.	the respective adverse effects of imipramine and desipramine on serum thyroid hormone levels and their accumulation in thyroid were investigated in male wistar rats. two groups of 30 rats were gavaged for 4 weeks with 30 mg/kg/day imipramine hydrochloride (imi) or desipramine hydrochloride (desi), while the control group (12 rats) received the arabic gum vehicle only. in the imi-treated group, the serum thyroxine (t4) level significantly decreased (by 13%) and imi and its metabolite desi were ac ...	1998	9742289
[value of (f18)-2-fluorodeoxyglucose pet scanning in staging mouth cavity carcinoma. comparative evaluation of pet findings before and after preoperative radiochemotherapy with histological and computerized tomography findings].	the lack of sensitivity and specificity of conventional imaging techniques based on morphological critera is responsible for considerable limitations in the staging and surveillance of oral cancer. therefore, this study investigates the contribution of [f18]-2-fluordesoxyglucose (fdg) positron emission tomography (pet) to tumor management with special regard to lymphnode involvement and therapeutic monitoring after radiotherapy.	1998	9738366
effect of chronic thyroxine treatment on pregnancy in rats: effects on oestrogen, progesterone, prolactin and gh receptors in uterus, liver and mammary gland.	we have previously shown that experimental hyperthyroidism produces premature and difficult delivery and absence of lactation in spite of apparently adequate luteolysis and lactogenesis. to study the possible causes of these alterations we measured the effect of treatment with t4 (0.25 or 1 mg kg(-1), s.c., daily, started 10-15 days before mating, ht0.25 and ht1) on serum hormones and their receptor (r) concentrations in reproductive tissues on day 20 of pregnancy (1800 hours), comparing them wi ...	1998	9738703
the role of trus-guided biopsies for determination of internal and external spread of prostate cancer.	this study hopes to define local extent of newly diagnosed prostate cancer by comparing sextant biopsies with transrectal ultrasound-guided diagnostic and staging biopsies. the study group consists of 110 men with sextant biopsy proven prostate cancer who presented for an opinion for prognosis and treatment options. all patients were rediagnosed and staged by transrectal ultrasound-guided and staging biopsies. tumor diagnosis was substantiated in 94.5% (104 of 110). for the 5.4% (6 of 110) not d ...	1998	9741417
neo-adjuvant chemotherapy and supracricoid partial laryngectomy with cricohyoidopexy for advanced endolaryngeal carcinoma classified as t3-t4: 5-year oncologic results.	historically, total laryngectomy with voice-prosthesis insertion and near-total laryngectomy were the surgical options advocated for advanced supraglottic and transglottic tumors classified as t3-t4.	1998	9744458
t4 dna ligase synthesizes dinucleoside polyphosphates.	t4 dna ligase (ec 6.5.1.1), one of the most widely used enzymes in genetic engineering, transfers amp from the e-amp complex to tripolyphosphate, adp, atp, gtp or datp producing p4a, ap3a, ap4a, ap4g and ap4da, respectively. nicked dna competes very effectively with gtp for the synthesis of ap4g and, conversely, tripolyphosphate (or gtp) inhibits the ligation of dna by the ligase. as t4 dna ligase has similar requirements for atp as the mammalian dna ligase(s), the latter enzyme(s) could also sy ...	1998	9744812
leptin levels in protracted critical illness: effects of growth hormone-secretagogues and thyrotropin-releasing hormone.	prolonged critical illness is characterized by feeding-resistant wasting of protein, whereas reesterification, instead of oxidation of fatty acids, allows fat stores to accrue and associate with a low-activity status of the somatotropic and thyrotropic axis, which seems to be partly of hypothalamic origin. to further unravel this paradoxical metabolic condition, and in search of potential therapeutic strategies, we measured serum concentrations of leptin; studied the relationship with body mass ...	1998	9745404
3,3'-diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors and of healthy subjects during acute stress.	in this article we describe the development of a highly sensitive, accurate, and reproducible ria for the measurement of 3,3'-diiodothyronine (3,3'-t2) in human serum and brain tissue. the detection limits were 1.8 fmol/g and 1.5 pmol/l in human brain tissue and serum, respectively. serum concentrations of 3,3'-t2 were measured in 4 groups of patients with nonthyroidal illnesses (nti), i.e. brain injuries (n = 15), sepsis (n = 24), liver disease (n = 22), and brain tumors (n = 23). the mean seru ...	1998	9745405
salsalate administration--a potential pharmacological model of the sick euthyroid syndrome.	this study examined salsalate ingestion as a model of the sequelae of acute inhibition of thyroid hormone binding to serum protein. one dose of salsalate (60-65 mg/kg) was administered to healthy volunteers. serum salsalate concentrations peaked at 2 h (82 micrograms/ml), then declined at 8 h to 1.2 micrograms/ml. serum total t4 (tt4) and total t3 (tt3) concentrations declined for 4 h, then recovered by 96 h, while t4 binding protein concentrations remained unchanged. tt3 was reduced to a greate ...	1998	9745409
effects of continuous light, continuous darkness and pinealectomy on pineal-thyroid-gonadal axis of the female indian palm squirrel, funambulus pennanti.	effects of continuous light (cl; 24l:0d), continuous darkness (cd; 24d:0l) and pinealectomy (px) were tested on pineal-thyroid-gonadal axis of a tropical seasonally breeding rodent, funambulus pennanti during its sexually active reproductive phase (february-march). cl had no effect on pineal, thyroid and ovarian functions as judged by weight, plasma level of thyroxine (t4) and estradiol (e2). however, cd reduced significantly thyroid and ovarian weight and plasma t4, and e2 levels. px was stimul ...	1998	9720970
metabolic consequences of 5-year growth hormone (gh) therapy in children treated with gh for idiopathic short stature. genentech collaborative study group.	in a multicenter study the metabolic effects of 5 yr of gh therapy in children with idiopathic short stature were evaluated. patients received 0.3 mg/kg.week recombinant human gh. of the 121 patients who entered the study, data for 62 were analyzed at the final 5 yr point. routine laboratory determinations were available for all 62 subjects at the 5 yr point. special laboratory determinations, such as postprandial glucose and insulin, were available for only a subset of patients. mean insulin-li ...	1998	9745413
are autoimmune thyroid dysfunction and depression related?	the objective of this study was to examine the relationship between autoimmune thyroid disease and depression in perimenopausal women. thyroid function [tsh, free t4, and thyroid peroxidase antibodies (tpo-ab)] and depression (using the edinburgh depression scale) were assessed cross-sectionally together with other determinants of depression. the subjects were 583 randomly selected perimenopausal women (aged 47-54 yr) from a community cohort of 6846 women. the main outcome measures were the occu ...	1998	9745425
blocking of kc1o4-induced metamorphosis in premetamorphic sea lampreys by exogenous thyroid hormones (th); effects of kc1o4 and th on serum th concentrations and intestinal thyroxine outer-ring deiodination.	immediately premetamorphic larval sea lampreys (petromyzon marinus) (>/=120 mm in length) were treated for 4, 8, or 16 weeks with one of two concentrations of either exogenous thyroxine (t4; 1 or 0.5 mg/l) or 3,5,3'-triiodothyronine (t3; 1 or 0.25 mg/l) in the presence or absence of the goitrogen potassium perchlorate (kc1o4; 0.05%) as well as with kc1o4 alone. larvae from all treatments were examined for signs of metamorphosis, changes in serum t4 and t3 concentrations (serum t4 and serum t3), ...	1998	9748403
ndd, the bacteriophage t4 protein that disrupts the escherichia coli nucleoid, has a dna binding activity.	early in a bacteriophage t4 infection, the phage ndd gene causes the rapid destruction of the structure of the escherichia coli nucleoid. even at very low levels, the ndd protein is extremely toxic to cells. in uninfected e. coli, overexpression of the cloned ndd gene induces disruption of the nucleoid that is indistinguishable from that observed after t4 infection. a preliminary characterization of this protein indicates that it has a double-stranded dna binding activity with a preference for b ...	1998	9748458
bacteriophage t4, a model system for understanding the mechanism of type ii topoisomerase inhibitors.	bacteriophage t4 provides a simple model system for analyzing the mechanism of action of antitumor agents that inhibit dna topoisomerases. the phage-encoded type ii topoisomerase is sensitive to many of the same antitumor agents that inhibit mammalian type ii topoisomerase, including m-amsa, ellipticines, mitoxantrone and epipodophyllotoxins. results from the t4 model system provided a convincing demonstration that topoisomerase is the physiological drug target and strong evidence that the drug- ...	1998	9748648
[treatment of infiltrating cancer of the bladder with cisplatin, fluorouracil, and concurrent radiotherapy: results of a pilot study].	pilot study to assess treatment feasibility and results of a 2-drug chemotherapy (ct) regimen administered concurrently with radiotherapy (rt) for muscle-invasive bladder cancer.	1998	9749084
thyroid hormone efflux from monolayer cultures of human fibroblasts and hepatocytes. effect of lipoproteins and other thyroxine transport proteins.	we have previously shown that human skin fibroblasts exposed to preformed low density lipoprotein (ldl)-thyroxine (t4) complexes internalize more t4 than they do when exposed to t4 alone. the system is set to function when the ldl receptor is up-regulated by reducing the intracellular concentration of cholesterol, and the ldl concentration outside the cell is in the range of the kda of the receptor. high density lipoproteins (hdl), albumin (hsa), transthyretin (ttr), and thyroxine-binding globul ...	1998	9751514
surgery versus surgery and postoperative radiotherapy in squamous cell carcinoma of the buccal mucosa: a comparative study.	the efficacy of postoperative radiotherapy for squamous cell carcinoma of the buccal mucosa was evaluated.	1998	9754758
effect of increasing running velocity on electroencephalogram in a field test.	this study was designed to measure the electroencephalogram (eeg) after exercise with increasing intensity. in a field test with increments in running velocity a 2-min eeg was recorded, together with blood lactate concentration and heart rate, after each stage. an individual protocol was used, with up to six stages of running to ensure comparability of exercise intensity among the subjects, in each of 19 athletes (17 men, 2 women) experienced in leisure-time running. the exercise consisted initi ...	1998	9754974
the expression of insulin-like growth factor-1 during adipogenesis in vivo: effect of thyroxine.	the expression of insulin-like growth factor-1 (igf-1) was examined in subcutaneous (sq) adipose tissue from 105-day pig fetuses by ribonuclease protection assays and in situ hybridization using a porcine igf-1 riboprobe. fetuses were hypophysectomized (hypox) at 70 days of gestation and at 90 days thyroxine (t4) pellets were implanted into some of the hypox fetuses. fetuses were removed and sq tissues collected on day 105 of gestation. rnase protection assays followed by scanning laser densitom ...	1998	9748401
[lipoprotein(a)--a risk factor for coronary sclerosis in patients with hypothyroidism].	in a group of patients with developed primary hypothyroidism the authors investigated in a longitudinal eight-month trial the effect of hormonal substitution therapy with thyroxine (t4) on the serum concentration of lipids, apolipoprotein b and lipoprotein (a)--risk factors for the development of early coronary sclerosis. in some patients--"responders"--gradually euhormonosis, normolipaemia are induced and clinical symptoms of hypothyroidism receded. in the second group of patients with hypothyr ...	1998	9750476
effect of interleukin-8 on production of tumor-associated substances and autocrine growth of human liver and pancreatic cancer cells.	we have previously reported that human liver cancer cell lines produce interleukin-8 (il-8) at high levels. those tumor cells appeared to express two kinds of il-8 receptor on their surface. in order to analyze the role of il-8 on the biological characteristics of those tumor cells, we suppressed il-8 production from human liver (huh-7 and hucc-t1) and pancreatic cancer cell lines (hup-t4) by treatment with il-8 antisense oligonucleotides. suppression of il-8 production resulted not only in inhi ...	1998	9755878
substrate oxidation and thyroid hormone response to the introduction of a high fat diet in formerly obese women.	to investigate the adaptation in substrate utilization to a sudden change in dietary composition from a medium fat to a high fat diet, during a three day period in formerly obese and never obese women.	1998	9756245
thyroid hormones promote early metamorphosis in grouper (epinephelus coioides) larvae.	the response of grouper larvae to the thyroid hormones, thyroxine (t4) and triiodothyronine (t3), was examined. two-, 3-, and 4-week-old grouper larvae were reared in seawater containing either t4 or t3 at 0.01, 0.1, and 1 ppm. t4 or t3 induced metamorphosis in all age groups in a dose-dependent manner. regardless of the size of the larvae, metamorphosis was completed in 2 days in larvae treated with 1 ppm of either t4 or t3; 3-4 days in larvae exposed to 0.1 ppm; and 5-6 days in larvae immersed ...	1998	9748398
[isolated intramedullary cysticercosis. case report].	cysticercosis is the most common parasitic disease affecting the central nervous system. although it is still very rare in europe, the frequency will increase due to the influx of immigrants from the endemic areas and increasing trips in these countries. spinal intramedullary cysticercosis is an uncommon manifestation of neurocysticercosis.	1998	9757347
iodide induces thyroid autoimmunity in patients with endemic goitre: a randomised, double-blind, placebo-controlled trial.	iodine is essential for normal thyroid function and the majority of individuals tolerate a wide range of dietary levels. however, a subset of individuals, on exposure to iodine, develop thyroid dysfunction. in this double-blind trial, we evaluated the efficacy and tolerability of low-dose iodine compared with those of levo-thyroxine (t4) in patients with endemic goitre.	1998	9758438
in vitro inhibition of thyroid hormone sulfation by hydroxylated metabolites of halogenated aromatic hydrocarbons.	earlier studies in our laboratory showed that hydroxylated metabolites of polychlorinated biphenyls (pcbs), dibenzo-p-dioxins (pcdds), and dibenzofurans (pcdfs) competitively inhibit thyroxine (t4) binding to transthyretin (ttr) and type i deiodinase (d1) activity. in this study, we investigated the possible inhibitory effects of hydroxylated metabolites of polyhalogenated aromatic hydrocarbons (phahs) on iodothyronine sulfotransferase activity. rat liver cytosol was used as a source of sulfotra ...	1998	9760282
comparison of the effects of iodine and iodide on thyroid function in humans.	concerns have been raised over the use of iodine for disinfecting drinking water on extended space flights. most fears revolve around effects of iodide on thyroid function. iodine (i2) is the form used in drinking-water disinfection. risk assessments have treated the various forms of iodine as if they were toxicologically equivalent. recent experiments conducted in rats found that administration of iodine as i- (iodide) versus i2 had opposite effects on plasma thyroid hormone levels. i2-treated ...	1998	9761130
diverse effects of mild and potent goitrogens on blood-brain barrier nutrient transport.	populations living in goitre endemic areas consume foods rich in a variety of goitrogens of different potencies and some are severely hypothyroid. recently we observed in wistar/nin rats that chronic feeding of kscn to dams produced only a moderate hypothyroidism and decreased the transport of 2-deoxy-d-glucose (2-dg) across the blood-brain barrier (bbb) in the offspring. the present studies were conducted to assess whether severe hypothyroidism would have greater effect on bbb nutrient transpor ...	1998	9761461
time-course analysis of cd25 and hla-dr expression on lymphocytes in interferon-beta 1b-treated multiple sclerosis patients.	to identify immunological markers that could be used to monitor relapsing-remitting multiple sclerosis (rrms) course/activity during interferon beta 1b (ifn beta 1b) therapy, we longitudinally studied hla-dr and cd25 expression by t lymphocytes in 15 ifn beta 1b-treated rrms patients. peripheral blood t cell subsets were analysed before therapy (t0), and after 1 (t1), 2 (t2), 3 (t3), 6 (t4) and 12 (t5) months after therapy initiation. hla-dr expression and the cd3+hla-dr+ t cell number showed a ...	1998	9762669
prognostic factors, recurrence, and survival in transitional cell carcinoma of the upper urinary tract: a 30-year experience in 252 patients.	to review a large single-center experience of patients treated for upper tract transitional cell carcinoma (tcc) with extended follow-up in order to identify patterns of recurrence, assess patient outcomes, and determine the impact of traditional prognostic factors.	1998	9763077
perioperative cytokine release during coronary artery bypass grafting in patients of different ages.	surgical interventions and cardiopulmonary bypass (cpb) induce a systemic inflammatory response with cytokine release. ageing is perceived as a process of impaired immune functions: il-1beta, il-6 and tumour necrosis factor-alpha (tnf-alpha) secretion are increased while il-2 release is reduced in advanced age. at present, little information is available about perioperative immune reactions at different stages of ageing. the aim of the present study was to compare il-6, il-1beta, tnf-alpha, il-1 ...	1998	9764599
cloning and expression of a novel, tissue specifically expressed member of the udp-galnac:polypeptide n-acetylgalactosaminyltransferase family.	we report the cloning and expression of the fifth member of the mammalian udp-galnac:polypeptide n-acetylgalactosaminyltransferase (ppgantase) family. degenerate polymerase chain reaction amplification and hybridization screening of a rat sublingual gland (rslg) cdna library were used to identify a novel isoform termed ppgantase-t5. conceptual translation of the cdna reveals a uniquely long stem region not observed for other members of this enzyme family. recombinant proteins expressed transient ...	1998	9765313
solution-state structure of a dna dodecamer duplex containing a cis-syn thymine cyclobutane dimer, the major uv photoproduct of dna.	the solution structures of a duplex dna dodecamer containing a cis-syn cyclobutane thymine dimer d(gcacgaat[cs]taag).d(cttaattcg tgc) and its native parent sequence were determined using nmr data collected at 750 mhz. the dodecamer sequence corresponds to the section of a site-specific cis-syn dimer containing 49-mer that was found to be the binding site for the dimer-specific t4 denv endonuclease v repair enzyme by chemical and enzymatic footprinting experiments. structures of both sequences we ...	1998	9753551
[hyperthyroidism induced by iodinated roentgen contrast media].	three patients with subclinical hyperthyroid goitre, women aged 63, 72 and 75 years following intravenous administration of an iodinated contrast medium developed hyperthyroidism with a marked rise of the concentration of free t4. thyreostatic agents were unsuccessful in two patients, the third was left untreated. hyperthyroidism improved spontaneously in all three. iodine-induced hyperthyroidism is rare and is usually encountered in patients with a pre-existent autonomous thyroid function. trea ...	1998	9763853
changes in thyroid hormone levels during growth hormone therapy in initially euthyroid patients: lack of need for thyroxine supplementation.	the occurrence of central hypothyroidism in previously euthyroid children during gh therapy has been reported with widely varying incidence. we monitored the acute effects on the hypothalamic-pituitary-thyroid axis in 15 euthyroid children with classic gh deficiency during the first year of gh therapy. all were initially euthyroid, as assessed by normal baseline tsh, t4, free t4, and t3 levels and negative antithyroid antibodies. a thyroid profile (t4, free t4 index, t3, rt3, and tsh) was perfor ...	1998	9768652
low growth hormone-binding protein in infants with congenital hypothyroidism.	we evaluated the circulating levels of gh, insulin-like growth factor i (igf-i), gh-binding protein (ghbp), and igf-binding protein-3 (igfbp-3) before l-t4 therapy in 19 infants with congenital hypothyroidism (ch), aged 12-29 days, diagnosed by neonatal screening and in a group of age- and sex-matched control infants. the same parameters were reevaluated after several months of treatment. serum ghbp was measured by the high performance liquid chromatography-gel filtration method; serum gh, igf-i ...	1998	9768678
the advantages of the lateral decubitus position after spinal anesthesia with hyperbaric tetracaine.	we investigated the effects of lateral decubitus positioning after spinal anesthesia with hyperbaric tetracaine on the spread of sensory blockade and hemodynamic variables. one hundred asa physical status i or ii patients scheduled for elective surgery to the lower limb received spinal anesthesia at a rate of approximately 0.1 ml/s using 0.5% tetracaine in 7.5% glucose with 0.125% phenylephrine in the lateral decubitus position with the operated side dependent. they were randomly divided into th ...	1998	9768787
regional sympathetic function in high spinal cord injury during mental stress and autonomic dysreflexia.	centrally mediated sympathetic stimulation of subjects who have suffered a spinal cord injury (sci) does not activate the decentralized part of the body below the level of the lesion, whereas experimental data indicate an exaggerated response above the level of the lesion. sci subjects may exhibit an autonomic dysreflexia reaction following afferent stimulation below the level of the lesion. in order to investigate the function of the sympathetic nervous system above and below the level of the l ...	1998	9762959
the effect of recombinant human thyrotropin (rhtsh) on thyroid function in mice and rats.	the vast majority of studies to determine the biological activity of recombinant human thyrotropin (rhtsh) have been carried out in the mouse. we have recently reported that 0.1 mg of rhtsh im (one-ninth the dose given in thyroid cancer patients) given to normal subjects elicits a brisk rise in serum thyroxine (t4), triiodothyronine (t3), and thyroglobulin (tg) concentrations. in contrast, in initial studies in the rat, a low dose of rhtsh failed to increase serum t4 or t3 concentrations. the pr ...	1998	9777753