Publications

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hemadsorption-negative plaque test: new assay for rubella virus revealing a unique interference.a simple and rapid plaque procedure has been developed for detecting and accurately assaying rubella virus in a noncytopathic virus-cell relationship. plaque-formation is based on the development, in individual cells infected with rubella virus, of a unique type of intrinsic interference to infection with newcastle disease virus. rubella virus-infected cells challenged with newcastle disease virus and tested for hemadsorption 15 hours later stand out as hemadsorption-negative areas. individual l ...19654283964
[research on the levels of attenuated poliomyelitis viruses as a function of the age of human embryonal cell cultures]. 19654284019
constitution and function of polyribosomes of poliovirus-infected hela cells. 19654157608
radioautographic studies of poliovirus binding by human immunoglobulins. 19654158158
viral antibody in the cerebrospinal fluid and serum of multiple sclerosis patients. 19654159846
[determination of the synthesis of poliovirus antigens with the use of gamma-globulin labled with i-131]. 19654161096
[neurovirulence of a new attenuated poliovirus type 3 (usol-d) in a monkey experiment]. 19654956397
poliovirus in febrile vaccinees. 196514219480
comparative sensitivity of human fetal diploid kidney cell strains and monkey kidney cell cultures for isolation of certain human viruses. 196514275846
stimulation of the incorporation of choline in poliovirus-infected cells. 196514277072
the fate of the inoculum in hela cells infected with poliovirus. 196514277073
[increase in the virus-activating effect of peracetic acid by n-propyl alcohol]. 196514277110
inhibition of poliovirus minute-plaque mutants and echoviruses by sulfated polysaccharides. 196514277676
location and regeneration of enteriovirus receptors of hela cells.zajac, ihor (hahnemann medical college, philadelphia, pa.), and richard l. crowell. location and regeneration of enterovirus receptors of hela cells. j. bacteriol. 89:1097-1100. 1965.-treatment of live hela cells with chymotrypsin or trypsin completely inactivated the viral receptors for coxsackievirus b3 and poliovirus t1, respectively. enzyme-treated cells regained their enterovirus receptor activity after incubation in culture medium. the existence of intracellular receptors for virus could n ...196514279119
characterization of virus neutralizing antibodies in human serum and nasal secretions. 196514279784
[on the determination of the neurovirulence of live poliovirus vaccines. ii. pathomorphology of ape poliomyelitis caused by attenuated polioviruses after intralumbar injection with special reference to differences between the virus types]. 196514271779
effect of enzymes on the interaction of enteroviruses with living hela cells.zajac, ihor (hahnemann medical college, philadelphia, pa.), and richard l. crowell. effect of enzymes on the interaction of enteroviruses with living hela cells. j. bacteriol. 89:574-582. 1965.-eight crude enzyme preparations and two crystalline enzymes were tested for ability to inactivate coxsackie group b and poliovirus receptors on living hela cells. receptor-destroying enzyme, erepsin, lysozyme, collagenase, proteinase, and cobra venom did not alter attachment of coxsackie b3 or poliovirus ...196514273631
chromatography of poliovirus on calcium phosphate and its application to the identification of vaccine progeny strains.ozaki, yoshikatsu (baylor university college of medicine, houston, tex.), arwin r. diwan, mizuho takizawa, and joseph l. melnick. chromatography of poliovirus on calcium phosphate and its application to the identification of vaccine progeny strains. j. bacteriol. 89:603-610. 1965.-virulent and attenuated polioviruses were studied chromatographically with calcium phosphate as adsorbent and neutral phosphate buffer as eluent. for type 1, the attenuated lsc2ab strain and the virulent mahoney strain ...196514273634
[comparison of enteroviruses isolated from clinical material and the viral spectrum of berlin sewage water]. 196514275535
mechanism of photodynamic inactivation of viruses containing rna and dna. 196514275611
toluca-3, a newly recognized enterovirus. 196514268630
interference between proflavine treated reovirus and related and unrelated viruses. 196514269254
properties of a new attenuated type 3 poliovirus. ii. neurovirulence tests on monkeys. 196514269256
properties of a new type 3 attenuated poliovirus. 3. a small scale trial with usol-d bac virus in a closed child community. 196514269257
detection of poliovirus type 1 in human cerebrospinal fluid. 196514264307
studies of antiviral factors in human milk and serum. 196514265897
swine polioencephalomyelitis viruses isolated from the brains and intestines of pigs. 196514266918
coxsackie a9 virus: mutation from drug dependence to drug independence.during the multiplication of coxsackie a9 virus dependent on 2 - (alpha - hydroxybenzyl) - benzimidazole there arise some drug-independent virus particles, which are either drug-resistant or drug-sensitive. we studied the properties of such revertant particles under conditions which did not favor the selection of resistant over sensitive virus particles. these particles exhibited a wide range of responses to 2-(alpha-hydroxybenzyl)-benzimidazole, from high sensitivity to high resistance. subclon ...196514258734
evidence for a persistent viral infection in a cell line derived from burkitt's lymphoma.henle, gertrude (children's hospital of philadelphia, philadelphia, pa.), and werner henle. evidence for a persistent viral infection in a cell line derived from burkitt's lymphoma. j. bacteriol. 89:252-258. 1965.-exposure of a cell line (eb2) derived from burkitt's lymphoma to vesicular stomatitis (vsv) and certain other viruses revealed a marked resistance of the cultures to infection. intact, but not disintegrated lymphoma cells induced resistance to vsv in human embryonic kidney, amnion and ...196514255673
photodynamic inactivation of enteroviruses.wallis, craig (baylor university college of medicine, houston, tex.), and joseph l. melnick. photodynamic inactivation of enteroviruses. j. bacteriol. 89:41-46. 1965.-enteroviruses are usually resistant to photodynamic inactivation, but they can be rendered completely photosensitive to proflavine at ph 9 to 10, if they are first purified by filtration through an anion resin. in addition, if enteroviruses are grown in cells maintained in a salt-glucose medium, they can be photosensitized. of 38 e ...196514255679
infectivity of poliovirus and its nucleic acid for dehydrated hela cell monolayers.smull, christine e. (the geisinger medical center, danville, pa.), and e. h. ludwig. infectivity of poliovirus and its nucleic acid for dehydrated hela cell monolayers. j. bacteriol. 89:52-57. 1965.-a study was made of the infectivity of poliovirus ribonucleic acid (rna), applied in various diluents, and of poliovirus, on cell monolayers which were washed free from their nutrient medium and allowed to dehydrate for periods up to 3 days prior to inoculation. the plaque formation of poliovirus rna ...196514255681
persistent polioviral infection of intact human amniotic membrane without apparent cytopathic effect.gresser, ion (children's hospital medical center, boston, mass.), charles chany, and john f. enders. persistent polioviral infection of intact human amniotic membrane without apparent cytopathic effect. j. bacteriol. 89:470-475. 1965.-poliovirus type i multiplied in organ cultures of the intact amniotic membrane. the behavior of the virus in this system differed markedly from that observed in monolayer cultures of trypsinized amnion cells, since replication of new virus was demonstrable througho ...196514255716
mechanism of dextran sulfate inhibition of attenuated poliovirus. 196514254581
anti-viral activity of two guanidine derivatives in vitro. 196514243432
infective agents and multiple sclerosis. 196514228156
cytology of the urine in children after oral poliovirus vaccine. 196514222016
[autohistioradiographic research on "enterohepatic circulation" of attenuated poliovirus type 3 of sabin labelled with i-131. experimental findings]. 196514341456
plaque formation by polio and measles viruses in bs-c-1 (hopps) cells derived from the african green monkey. 196514346117
a study of the storage stability of viral antisera. 196514346126
persistent infection of human conjunctiva cell cultures by myxovirus parainfluenza 3. 196514346128
ultracentrifugation in the concentration and detection of enteroviruses.ultracentrifugation has been evaluated as a method of concentrating enteroviruses from suspensions whose initial titers ranged from 1.7 x 10(8) to 1.6 x 10(-2) plaque-forming units (pfu) per ml. a technique employing a "trap" of 0.1 ml of 2% gelatin solution at the point at which the pellet forms in tubes for the number 30 and number 50 rotors of the spinco model l preparative ultracentrifuge has been tested and found to have a number of advantages. qualitative studies have been performed to det ...196514325278
factors in the membrane filtration of enteroviruses.the filtration of two species of enteroviruses through membranes of porosity ranging from 50 to 220 mmu was studied. it was shown that extensive or total losses of virus may attend filtration at these porosities, apparently owing to adsorption of the virus to the membrane matrix. this could be minimized by the incorporation of serum into the virus suspension at the time of filtration, or by pretreating the membrane with serum or with a gelatin solution. it was also found that the first few drops ...196514325282
comparison of the elution and adsorption of picornaviruses by cotton and calcium alginate wool swabs.the recovery of picornaviruses by cotton and calcium alginate wool swabs was studied by use of prototype strains of poliovirus 1, echovirus 1, coxsackievirus a9, and rhinovirus 16/60. no significant differences in recovery of viruses by the two types of swabs could be demonstrated. it is suggested that use of cotton swabs in the virus laboratory be continued, since wool swabs may favor the recovery of undesirable bacterial contaminants. adsorption of viruses by cotton and wool swabs was similar ...196514325287
the influence of hydrocortisone on cellular susceptibility to infection with virulent and avirulent poliovirus. 196514328220
rescue of one phenotype in mixed infections with heat-defective mutants of type 1 poliovirus. 196514328613
antigenic differentiation of polioviruses by absorbed hyperimmune sera. i. antigenic differentiation of type i strains of diverse origin. 196514328695
cortisone on in vitro viral infection. ii. effect on distribution of cytopathic effect and acid phosphatase arrangement in human cells infected with poliovirus. 196514328963
molecular weight of a poliovirus protein. 196514329129
similarities of biophysical properties of several human enteroviruses as shown by density gradient ultracentrifugation of mixtures of the viruses. 196514329140
inhibition by exogenous interferon of replication of poliovirus ribonucleic acid in chick brain.youngner, julius s. (university of pittsburgh, pittsburgh, pa.), and marion e. kelly. inhibition by exogenous interferon of replication of poliovirus ribonucleic acid in chick brain. j. bacteriol. 90:443-445. 1965.-the replication of poliovirus was studied after the intracerebral inoculation of infectious ribonucleic acid (rna) into the brains of 2-day-old chicks; these animals are not susceptible to intact virus. single-cycle replication of virus, which reached a peak in about 12 hr, was comple ...196514329459
intracellular visualization of fluorochrome labelled poliovirus-rna by direct fluorescence microscopy at initial phase of the infection. 196514330452
studies of some substances with antiviral activity. ii. 2,4-dioxo-5-thiazolidine acetic acid derivatives (dft) as an inhibitor of growth of herpes virus and poliovirus type i in cell cultures of human embryonic kidneys. 196514334410
in vivo antiviral activity of 1,3-bis(2-chloroethyl)-1-nitrosourea.a prolongation in the lives of swiss mice inoculated intracerebrally with lymphocytic choriomeningitis virus (lcm) was observed after treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu). a variety of treatment schedules, including therapy once or twice daily up to 17 days and single treatments at various times after virus inoculation, were employed. virus titers ranging to greater than 10(4) were detected in the blood and brains of surviving drug-treated animals. in three comparative stud ...196514339266
adaptation of freshly isolated strains of dengue viruses to tissue culture. 196514336155
a procedure for screening antiviral substances. the use of agar discs in the agar diffusion method. 196514336168
infectious rna synthesized in monkey kidney tissue culture cells infected with poliovirus. 196514323992
use of micro technique for serum neutralization and virus identification. 196514290598
in vitro secondary 19s and 7s antibody responses to poliovirus in membrane cultures of separated spleen cells. 196514292777
[apropos of isolation of pure enterovirus preparations by isopyknic gradient centrifugation in cesium chloride]. 196514292780
molecular properties of poliovirus neutralizing antibodies in human colostrum and milk. 196514292781
extraction of cell-associated virus without damage of the culture. (brief report). 196514292789
studies on the mechanism of poliovirus-induced cell damage. i. the relation between poliovirus,-induced metabolic and morphological alterations in cultured cells. 196514293297
studies on the mechanism of poliovirus-induced cell damage. ii. the relation between poliovirus growth and virus-induced morphological changes in cells. 196514293299
glucose consumption of cultured cells before and after infection with enteroviruses or virus nucleic acids. 196514293873
preparation and standardization of coxsackievirus reference antisera. i. for twenty-four group a viruses. 196514294414
the anti-viral action of rutilantin a. 196514283029
replication of animal viruses as studied by electron microscopy. 196514286808
on the growth of certain "newer" respiratory viruses in organ cultures. 196514286939
mutation to increased virulence during chronic infection with sabin lsc.2ab type i poliovirus. 196514286946
intracellular distribution of poliovirus induced rna-dependent rna polymerase (replicase) in detroit-6 cells during the replication cycle. 196514282032
protection offered to poliovirus-infected tissue-culture cells by methoxy- and hydroxy-methyl compounds related to 2-benzylbenzimidazole. 196514270709
survival of type 1 and type 3 polio vaccine virus in blowflies. (phaenicia sericata) at 40 degree c. 196514301631
[experiments on viral excretion and serum differentiation during a poliomyelitis epidemic following oral vaccination with poliovirus type-3]. 196514304400
simultaneous administration of oral polio vaccine and globulin-modified attenuated measles-virus vaccine. 196514288455
preliminary communication on the survival, the sites harboring virus and genetic stability of poliovirus in cockroaches. 196514297822
effects of cortisone on in vitro viral infection. i. inhibition of cytopathogenesis by polio, rabies and yellow fever viruses in human embryonic cells. 196514297833
virus-free infective centers produced by photodynamic inactivation of poliovirus in rhesus kidney cell suspensions. 196514297846
effect of 3-methylmercapto4-thio-6-azauracil on picornavirus multiplication. 196514299356
two outbreaks of echovirus 14 infection: a possible interference with oral poliovirus vaccine and a probable association with aseptic meningitis. 196514311095
infection and immunization in multiple sclerosis. 196514313505
establishment and characteristics of two cell lines from embryos of dd-stock mouse. 196514314111
[the persistence of poliomyelitis virus type 1 in vaccinated individuals and in their environment]. 196514317139
electron microscopic study of the formation of poliovirus. 196514319710
the formation and properties of poliovirus neutralizing antibody. 5. changes in the quality of 19s and 7s rabbit antibodies following immunization. 196514320670
enterovirus immunizing antigens in the form of cation-stabilized and concentrated virus preparations. 196514322585
plaque development and induction of interferon synthesis by rmc poliovirus.johnson, terry c. (university of minnesota, minneapolis), and leroy c. mclaren. plaque development and induction of interferon synthesis by rmc poliovirus. j. bacteriol. 90:565-570. 1965.-plaque development by rmc poliovirus on human amnion cell monolayers was investigated with regard to autointerference and to the effect of acid-agar overlay on plaquing efficiency. the virus was inhibited by acid-agar overlay, thereby exhibiting the d(-) marker typical of attenuated poliovirus strains. in addit ...196516562049
the inhibition by actinomycin d of poliovirus multiplication hep 2 cells. 19654285378
use of blood collected on filter paper disks in neutralization tests for poliovirus antibody. 19654284838
effects on host cell metabolism following synchronous infection with poliovirus. 19654159191
oral poliovirus vaccine. history of its development and prospects for eradication of poliomyelitis. 19655321495
titration and neutralization of poliovirus in micro tissue culture under increased carbon dioxide.modification of the micro tissue culture technique, including incubation under increased co(2), resulted in prolongation of the viability of the cells. as a consequence, satisfactory titrations of poliovirus and of poliovirus antiserum have been achieved by the micro method. the technique offers a number of advantages over conventional methods.19654286244
the excretion of type 1 poliovirus after challenge following primary immunization with quadruple, salk and sabin vaccines. 19654286153
infectious poliovirus rna: a sensitive method of assay. 19654285107
characterization of ribonuclease-resistant rna from poliovirus-infected hela cells. 19654286834
a poliovirus-induced double-stranded rna: double-helical properties and labelling kinetics. 19654286308
poliovirus neutralizing antibody in cerebrospinal fluid. 19654284444
[on the splitting of physically intact poliovirus particles into nucleic acid and empty protein shells on heating]. 19654380217
kinetic studies on the thermal degradation of purified poliovirus. 19654286098
surveillance of the safety of oral poliomyelitis vaccine in england and wales 1962-4. 196514321222
genetic and non-genetic factors in chromatographic behaviour of poliovirus. 19654287494
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