Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| cytomegalovirus seropositivity and serum total cholesterol levels in young patients. | atherosclerosis is a chronic inflammatory disease of arteries, associated with multiple genetic and environmental factors, including hypertension, diabetes mellitus, cigarette smoking, modified and elevated ldl cholesterol, elevated plasma homocysteine, and infectious microorganisms such as chlamydia pneumoniae and cytomegalovirus (cmv). cmv has been implicated in atherogenesis by epidemiological studies, animal research, and molecular analyses that have demonstrated cmv nucleic acids within hum ... | 2001 | 11337905 |
| asymptomatic respiratory infection with chlamydia pneumoniae : what does it mean? | 2001 | 11348931 | |
| role of infection in alzheimer's disease. | alzheimer's disease (ad) is a chronic condition in which inflammation has been shown to contribute to neurodegeneration. current thinking suggests that deposition of beta-amyloid in the brain promotes inflammation resulting in neuronal damage/death. alternatively, our data suggest that chronic inflammation observed in late-onset sporadic ad may be stimulated by infection with the obligate, intracellular bacterium, chlamydia pneumoniae. our results indicate that c. pneumoniae is found in high fre ... | 2001 | 11794745 |
| use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study. | eradication of chlamydia pneumoniae infection and inhibition of elastolytic matrix metalloproteinases with doxycycline have been suggested to reduce the growth rates of small abdominal aortic aneurysms (aaa). we designed a study to investigate the efficacy of doxycycline in reducing the expansion of small aaas. | 2001 | 11668312 |
| [implication and mode of action of infectious agents in the formation of atheromatous plaques. infection and atherosclerosis]. | different kinds of infectious agents seem to be implied in the atherosclerotic process. indeed, some bacteria and viruses have been identified in atherosclerotic lesions: chlamydia pneumoniae, helicobacter pylori, streptococcus sanguis, porphyromonas gingivalis, herpes simplex viruses type 1 and 2, coxsakievirus b and hepatitis virus a. by their ability to induce antigenic and functional changes in the cells of the vascular wall (endothelial cells, smooth muscle cells, monocytes/macrophages, and ... | 2001 | 11776694 |
| overview of infections and cardiovascular diseases. | microbes have been proposed as inciting agents of tissue injury and inflammation, both of which underlie the pathogenesis of atherosclerosis. viruses, including the herpes simplex virus and cytomegalovirus, as well as bacteria such as chlamydia pneumoniae, have been implicated in the process. in vitro, these agents promote a proinflammatory and a procoagulant phenotype in vascular cells. viruses augment cell accumulation through alterations of apoptosis. infectious agents may play a role in path ... | 2001 | 11586278 |
| acute-phase proteins and chlamydia pneumoniae infection: which one is more important in acute coronary syndrome? | elevated levels of acute-phase proteins, a systemic marker for inflammation, predict coronary events; chlamydia pneumoniae (c. pneumoniae) infection is associated with coronary atherosclerosis. the present study investigated whether inflammation or infection is involved in the pathogenesis of acute coronary syndrome (acs) and which one has the more important role. the study group comprised 49 patients with angiographically diagnosed acs, 48 cases of chronic coronary heart disease (cchd), and 44 ... | 2001 | 11665787 |
| in vitro susceptibility and eradication of chlamydia pneumoniae cardiovascular strains from coronary artery endothelium and smooth muscle cells. | recovery of viable chlamydia pneumoniae from atheromas of coronary heart diseases patients has initiated pilot studies to eradicate c. pneumoniae from vascular tissue by antibiotic treatment. to provide data for the selection of effective antibiotics, we investigated the in vitro activity of anti-chlamydial antibiotics to eliminate vascular strains of c. pneumoniae from coronary endothelial and smooth muscle cells, celltypes that are involved in the pathogenesis of atherosclerosis. | 2001 | 11713894 |
| association between sézary t cell-activating factor, chlamydia pneumoniae, and cutaneous t cell lymphoma. | sézary t cell-activating factor (saf) was originally defined as an inducer of functional interleukin-2 (il-2) receptors on normal and malignant t cells in patients suffering from sézary syndrome. in fact, a combination of saf and il-2 stimulated the propagation of t cell lines from the peripheral blood mononuclear cells (pbmc) of those patients, with approximately one third of those cell lines containing the predominant malignant clone as determined via cytogenetic and/or t cell receptor gene re ... | 2001 | 11594584 |
| characterization of antiapoptotic activities of chlamydia pneumoniae in human cells. | chlamydia pneumoniae is an obligate intracellular bacterium which frequently causes airway infection in humans and has been implicated in atherosclerosis. here we show that infection with c. pneumoniae protects hela human epithelioid cells against apoptosis induced by external stimuli. in infected hela cells, apoptosis induced by staurosporine and cd95-death-receptor signaling was strongly reduced. upon treatment with staurosporine, generation of effector caspase activity, processing of caspase- ... | 2001 | 11598088 |
| macrolide treatment after coronary stent placement. | 2001 | 11784661 | |
| antibodies anti-chlamydia pneumoniae and anti-mycoplasma pneumoniae in patients with negative serology for hantavirus. retrospective study. | the seroprevalence of chlamydia pneumoniae and mycoplasma pneumoniae in hantavirus seronegative patients, who had symptoms and signs compatible with pneumonia was established. for this purpose we used the indirect fluorescent antibody test. titers > or = 1:16 for c. pneumoniae and m. pneumoniae were found in 8.6% and 17.1% of the serum, respectively, showing evidence of recent or current infection. | 2001 | 11784935 |
| chlamydia trachomatis and mycobacterium tuberculosis lung infection in an hiv-positive homosexual man. | a 31-year-old homosexual man, who was human immunodeficiency virus (hiv)-positive was admitted for fever and cough. chest computed tomography (ct) revealed the presence of diffuse interstitial reticular nodulation, and brain nuclear magnetic resonance imaging showed the presence of nodular frontal lesions. microscopic examination of sputum and other body fluids showed the presence of acid-fast bacilli and culture-only growth mycobacterium tuberculosis. serology for respiratory tract pathogens wa ... | 2001 | 11788074 |
| constant relative rate of protein evolution and detection of functional diversification among bacterial, archaeal and eukaryotic proteins. | detection of changes in a protein's evolutionary rate may reveal cases of change in that protein's function. we developed and implemented a simple relative rates test in an attempt to assess the rate constancy of protein evolution and to detect cases of functional diversification between orthologous proteins. the test was performed on clusters of orthologous protein sequences from complete bacterial genomes (chlamydia trachomatis, c. muridarum and chlamydophila pneumoniae), complete archaeal gen ... | 2001 | 11790256 |
| chronic infections and atherosclerosis. | the inability of traditional risk factors such as hypercholesterolemia, hypertension, and smoking to explain the incidence of atherosclerosis (at) in about 50% of the cases prompted a search for additional putative risk factors involved in the development of the disease. infectious agents have long been suspected to initiate/contribute to the process of at. it has also been suggested that inflammation, either related to infectious agents or independent from infection, may mediate the atherogenic ... | 2001 | 11791347 |
| [unrecognized chronic bronchitis]. | 2001 | 11721487 | |
| evidence that chlamydia pneumoniae affects platelet activity in patients with acute myocardial infarction and st-segment elevations. | this study concerns platelet activity at myocardial infarctions and possible relationships with chlamydia pneumoniae seroreactivity. fourteen patients with acute myocardial infarction and st-segment elevations were enrolled. they all received thrombolytic therapy. the subjects were examined within 24 h after hospital admission (day 1) and after 6 months of recovery. on day 1, c. pneumoniae igm antibody titres were analysed and on day 1 and during recovery c. pneumoniae igg and soluble p-selectin ... | 2001 | 11728040 |
| atherosclerosis and tuberculosis: are they both chronic infectious diseases? | 2001 | 11728058 | |
| advances in experimental dyslipidemia and atherosclerosis. | among the models of dyslipidemia and atherosclerosis, a number of wild-type, naturally defective, and genetically modified animals (rabbits, mice, pigeons, dogs, pigs, and monkeys) have been characterized. in particular, their similarities to and differences from humans in respect to relevant biochemical, physiologic, and pathologic conditions have been evaluated. features of atherosclerotic lesions and their specific relationship to plasma lipoprotein particles have been critically reviewed and ... | 2001 | 11555665 |
| prevalence of chlamydia pneumoniae in peripheral blood mononuclear cells in italian patients with acute ischaemic heart disease. | chlamydia pneumoniae infection generally starts in the respiratory tract and probably disseminates systemically in the blood stream within alveolar macrophages. we investigated the prevalence of c. pneumoniae dna in peripheral blood mononuclear cells (pbmc) in patients with acute ischaemic heart disease. samples of blood were obtained from 93 consecutive patients with acute ischaemic heart disease and from 42 healthy subjects, for detection of c. pneumoniae dna in pbmc by polymerase chain reacti ... | 2001 | 11730834 |
| the significance of chlamydia pneumoniae in symptomatic carotid stenosis. | an association between symptomatic carotid stenosis and recent infection with chlamydia pneumoniae is reported. thirty-five patients (20 symptomatic and 15 asymptomatic) with carotid stenosis of 70% to 90% underwent carotid endarterectomy. endarterectomy was performed without patch and shunt; the average occlusion time of the internal carotid artery was 14 +/- 3 min. the atheromatic plaque and a portion of the thyroid artery were examined with polymerase chain reaction and peripheral vein blood ... | 2001 | 11570660 |
| prevention and management of infection in children with sickle cell anaemia. | sickle cell anaemia (sca) predisposes a child to infections for various reasons, including increased bone marrow turnover, poor perfusion and functional asplenia leading to decreased opsonisation of polysaccharide encapsulated organisms. bacteria and viruses that most frequently cause serious infections in children with sickle cell disease are streptococcus pneumoniae, haemophilus influenzae type b, salmonella spp., escherichia coli, staphylococcus aureus, mycoplasma pneumoniae, chlamydia pneumo ... | 2001 | 11735665 |
| mechanism of arterial infection by chlamydia pneumoniae. | 2001 | 11571261 | |
| c-reactive protein levels and viable chlamydia pneumoniae in carotid artery atherosclerosis. | an elevated serum level of c-reactive protein, an inflammatory marker, is an independent predictor of stroke and coronary artery disease. to determine whether chronic infection with chlamydia pneumoniae, which has been identified in atherosclerotic plaques, is responsible for systemic inflammation, we studied the association between serum c-reactive protein levels and infection of carotid artery atherosclerotic plaque with viable c pneumoniae. | 2001 | 11739967 |
| potential infectious etiologies of atherosclerosis: a multifactorial perspective. | coronary heart disease (chd) contributes substantially to illness and death worldwide. experimental studies demonstrate that infection can stimulate atherogenic processes. this review presents a spectrum of data regarding the link between chd and infection. in addition, the need for improved diagnostic tools, the significance of multiple pathogens, and potential intervention strategies are discussed. | 2001 | 11747688 |
| interferon-beta induction by chlamydia pneumoniae in human smooth muscle cells. | clinical studies have suggested a causal or contributory role of chlamydia pneumoniae infection in asthma and atherosclerosis. the activation of synthetic functions of smooth muscle cells (smc) including the production of cytokines and growth factors plays a major role in the formation of fibrous atherosclerotic plaques as well as in structural remodelling of the airway wall in chronic asthma. in this study we demonstrated that c. pneumoniae induced the production of low levels of interferon (if ... | 2001 | 11750216 |
| oxidative processes in human promonocytic cells (thp-1) after differentiation into macrophages by incubation with chlamydia pneumoniae extracts. | human monocytes differentiated into macrophages by chlamydia pneumoniae were able to oxidize blood lipoproteins, as discovered by kalayoglu et al. (1998). using a model of human promonocytic cells (thp-1), the cells were differentiated into macrophages by preincubation with c. pneumoniae extract, and further stimulated by phorbol myristate acetate. in these conditions, the differentiated cells oxidized a thiol compound and released superoxide anion as demonstrated respectively by gas liquid chro ... | 2001 | 11563864 |
| ultrastructural study of chlamydia pneumoniae in a continuous-infection model. | we have established an in vitro model of long-term continuous chlamydia pneumoniae infection in hep-2 cells. using transmission electron microscopy, we demonstrated the presence of spontaneous abnormal chlamydial inclusions similar in appearance to the persistent chlamydial forms induced in vitro by treatment with cytokines or antibiotics or by nutrient deprivation. | 2001 | 11574601 |
| chlamydia pneumoniae infection in acute exacerbations of chronic obstructive pulmonary disease: analysis of 250 hospitalizations. | two hundred fifty hospitalizations were included in a serologically based prospective study to assess the role of chlamydia pneumoniae in episodes of acute exacerbation of chronic obstructive pulmonary disease (aecopd) and the percentage of copd patients chronically infected with this pathogen. chlamydia pneumoniae-specific igg, iga and igm antibody titers were determined using a commercial kit with the microimmunofluorescence method. a significantly higher geometric mean titer in the copd patie ... | 2001 | 11757970 |
| chlamydia pneumoniae-infected monocytes exhibit increased adherence to human aortic endothelial cells. | interactions between monocytes and endothelial cells play an important role in the pathogenesis of atherosclerosis, and monocyte adhesion to arterial endothelium is one of the earliest events in atherogenesis. work presented in this study examined human monocyte adherence to primary human aortic endothelial cells following monocyte infection with chlamydia pneumoniae, an intracellular pathogen associated with atherosclerosis by a variety of sero-epidemiological, pathological and functional studi ... | 2001 | 11580983 |
| [prevalence of chlamydia pneumoniae antibodies in patients with coronary heart disease]. | a possible role of infectious agents in the pathogenesis and progression of cardiovascular system diseases has been postulated by many scientists. the purpose of our study was to evaluate the correlation between chlamydia pneumoniae infections and coronary heart disease. a group of 211 patients including: 120 patients with coronary heart disease (chd) [63 patients enrolled for precutaneous coronary interventions (ptca), 14 with proven restenosis after ptca and 43 after coronary artery bypass gra ... | 2001 | 11761832 |
| antibiotic use and occlusive stroke: weighing a negative result. | 2001 | 11583648 | |
| biology and clinical significance of chlamydiae. | 2001 | 11764738 | |
| [establishment and experimental study on mouse model of chlamydia pneumoniae pneumonitis]. | to evaluate mice as experimental animals for chlamydia pneumoniae (c. pneumoniae) infection and investigate the pathogenesis of c. pneumoniae pneumonitis. | 2001 | 11770419 |
| differential expression of pmp10 in cell culture infected with chlamydia pneumoniae cwl029. | the complete genome of chlamydia pneumoniae contains a total of 21 genes encoding polymorphic membrane proteins (pmp). from this large pmp family three genes, pmp8, pmp10 and pmp11, were cloned and antibodies against recombinant full-length pmp proteins were produced. indirect immunofluorescence microscopy of hep-2 cells infected with c. pneumoniae cwl029 was performed with the pmp antibodies in combination with a chlamydia-specific anti-lipopolysaccharide (lps) antibody. this double staining te ... | 2001 | 11583841 |
| impact of infectious burden on extent and long-term prognosis of atherosclerosis. | recent findings suggest a causative role of infections in the pathogenesis of atherosclerosis. in hypothesizing an association between infectious agents and the development of atherosclerosis, we would expect a correlation to the extent of atherosclerosis. moreover, this effect could be multiplied by the number of pathogens to which an individual had been exposed. | 2002 | 11772870 |
| chlamydia pneumoniae secretion of a protease-like activity factor for degrading host cell transcription factors required for [correction of factors is required for] major histocompatibility complex antigen expression. | chlamydia pneumoniae is a causative agent for many respiratory infections and has been associated with cardiovascular diseases in humans. the pathogenicity of c. pneumoniae is thought to depend on its ability to cause persistent infection and to evade host defense. genome sequence analysis indicates that c. pneumoniae encodes a homologue of a chlamydial protease-like activity factor from c. trachomatis (cpafct). we designated the c. pneumoniae homologue as cpafcp. recombinant cpafcp was produced ... | 2002 | 11748200 |
| genomic approach for analysis of surface proteins in chlamydia pneumoniae. | chlamydia pneumoniae, a human pathogen causing respiratory infections and probably contributing to the development of atherosclerosis and heart disease, is an obligate intracellular parasite which for replication needs to productively interact with and enter human cells. because of the intrinsic difficulty in working with c. pneumoniae and in the absence of reliable tools for its genetic manipulation, the molecular definition of the chlamydial cell surface is still limited, thus leaving the mech ... | 2002 | 11748203 |
| the emerging role of atypical pathogens in community-acquired pneumonia. | community-acquired pneumonia (cap) constitutes a major cause of morbidity and mortality. although streptococcus pneumoniae remains the bacterium most commonly implicated in cap, the atypical respiratory pathogens mycoplasma pneumoniae, legionella species, and chlamydia pneumoniae are being isolated with increasing frequency contrary to previous beliefs, these agents are capable of causing severe as well as mild-to-moderate illness. moreover, they can affect all age groups. indeed, atypical patho ... | 2002 | 11791627 |
| effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on chlamydia pneumoniae in a continuous-infection model. | persistent infections with chlamydia pneumoniae have been implicated in the development of chronic diseases, such as atherosclerosis and asthma. although azithromycin, clarithromycin, and levofloxacin are frequently used for the treatment of respiratory c. pneumoniae infections, little is known about the dose and duration of therapy needed to treat a putative chronic c. pneumoniae infection. in this study, we investigated the effect of prolonged treatment with azithromycin, clarithromycin, or le ... | 2002 | 11796350 |
| in vitro activities of bms-284756 against chlamydia trachomatis and recent clinical isolates of chlamydia pneumoniae. | the in vitro activities of bms-284756 (a novel des-fluoroquinolone), levofloxacin, moxifloxacin, and clarithromycin were tested against 5 strains of chlamydia trachomatis and 20 isolates of chlamydia pneumoniae. the mic at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by bms-284756 for all isolates of c. pneumoniae and c. trachomatis was 0.015 microg/ml (range, 0.015 to 0.03 microg/ml). bms-284756 was the most active ... | 2002 | 11796366 |
| association analysis of polymorphisms at the interleukin-1 locus in essential hypertension. | infection with microorganisms such as helicobacter pylori and chlamydia pneumoniae has been associated with coronary heart disease (cad) and hypertension (ht). infection increases the release of pro-inflammatory cytokines, thus facilitating interactions that lead to vascular damage and other effects. we hypothesized that genetically determined differences in activity or responsiveness of cytokine(s) might contribute to ht. the interleukin-1 gene (il1) cluster on chromosome 2q14 contains three re ... | 2002 | 11840488 |
| unraveling the host immune response to vacuolar pathogens. | 2002 | 11864817 | |
| seroepidemiology of chlamydia pneumoniae in japan between 1991 and 2000. | to clarify the endemic and epidemic status of chlamydia pneumoniae in japan, the incidence of anti-c pneumoniae antibody was evaluated over a period of 10 years. | 2002 | 11865005 |
| mycoplasma and chlamydia pneumonia in pediatrics. | mycoplasma pneumoniae and chlamydia pneumoniae are common respiratory pathogens in children 5 years of age and older. although distinctly different in structure, these organisms share similar epidemiologic and clinical characteristics in human infection and disease. pneumonia caused by these organisms usually occurs after infection of the upper respiratory tract, but may occur in the absence of antecedent upper respiratory infection. diagnosis of infection with c. pneumoniae and m. pneumoniae is ... | 2002 | 11891514 |
| evidence for infectious agents in cardiovascular disease and atherosclerosis. | during the past decade, several novel risk factors for atherosclerosis, including inflammation and infections, have been reported. seroepidemiological studies suggest an association between several microbes and coronary heart disease. microbes or their structural components are found in atherosclerotic plaques, but the only intact microbes commonly present are herpes viruses and chlamydia pneumoniae. these agents are able to initiate and accelerate atherosclerosis in animal models. if they cause ... | 2002 | 11892489 |
| relation of antibiotic use to risk of myocardial infarction in the general population. | there are conflicting reports of an association between chlamydia pneumoniae (c. pneumoniae) infection and coronary artery disease (cad); randomized trials of antibiotics for the secondary prevention of cad are currently underway. physicians may be tempted to believe that their choice of antibiotic class in treating any infection may alter the risk of cad. our objective was to determine if the use of antibiotics with antichlamydial activity in the general population reduces the risk of myocardia ... | 2002 | 11779516 |
| mannose-receptor positive and negative mouse macrophages differ in their susceptibility to infection by chlamydia species. | it has been shown that n-linked high mannose type oligosaccharides competitively inhibits attachment to and infectivity of chlamydiae in hela cells. to further study whether mannose moieties are involved in the infectivity of chlamydiae, the susceptibility of mannose-receptor negative j774a and positive j774e mouse macrophages to chlamydia trachomatis, chlamydia psittaci and chlamydia pneumoniae was evaluated. c. trachomatis infected mannose-receptor positive cells better than mannose-receptor n ... | 2002 | 11782120 |
| effect of fenofibrate on chlamydia pneumoniae antibody levels in patients with coronary artery disease. | 2002 | 11779542 | |
| antibodies to 60-kilodalton heat shock protein and outer membrane protein 2 of chlamydia pneumoniae in patients with coronary heart disease. | evidence linking chlamydia pneumoniae infection to atherosclerosis and to atherothrombotic events has recently emerged. a primary candidate implicated in these pathogenetic events is the 60-kda chlamydial heat shock protein (hsp60). another putative candidate to activate a potential proinflammatory mechanism is the chlamydial outer membrane protein 2 (omp2). we have generated both hsp60 and omp2 recombinant antigens in a nondenatured form and shown that (i) the two antigens were highly immunogen ... | 2002 | 11777831 |
| iron chelation and hydroxyl radical scavenging reduce the inflammatory response of endothelial cells after infection with chlamydia pneumoniae or influenza a. | chronic low-grade inflammation is associated with increased risk of vascular diseases. the source of inflammation is unknown but may well be chronic and/or repetitive infections with microorganisms. direct infection of endothelial cells (ecs) may also be a starting point for atherogenesis by initiating endothelial procoagulant activity, increased monocyte adherence and increased cytokine production. we hypothesized that iron-mediated intracellular hydroxyl radical formation after infection is a ... | 2002 | 11886437 |
| [non-transmissible diseases and infections]. | 2002 | 11887222 | |
| prospective case-control study of chlamydia, legionella and mycoplasma infections in patients with pityriasis rosea. | a double-blind placebo-controlled trial reported the benefit of erythromycin in treating pityriasis rosea (pr), a postulated mechanism being the eradication of bacteria susceptible to erythromycin. the aim of this study was to investigate the association between pr and chlamydia pneumoniae, c. trachomatis, legionella longbeachae, l. micdadei, l. pneumophila, and mycoplasma pneumoniae infections. we recruited 13 patients aged seven to 46 years (mean: 26.8 years) diagnosed to have pr in a primary ... | 2002 | 11872416 |
| chlamydia pneumoniae and severity of asthma. | a substantial increase in the prevalence of asthma in the western world during the last few decades has led to a continuous search for novel factors that might be involved in the development of the disease. we carried out a study to clarify whether there is a relationship between severity of asthma and chlamydia pneumoniae-specific titres at the group level and whether antibodies to the 60 kda chlamydial heat shock protein (chsp60) are associated with asthma. a total of 116 (31 men, 85 women) co ... | 2002 | 11874160 |
| chlamydia pneumoniae and atherosclerosis: critical assessment of diagnostic methods and relevance to treatment studies. | a number of studies have found that inflammation of the vessel wall plays an essential role in both the initiation and progression of atherosclerosis and erosion and fissure and the eventual rupture of plaques. chlamydia pneumoniae is one of the infectious agents that have been investigated as possible causes of this inflammation. initial studies of the association of c. pneumoniae and cardiovascular disease (cvd) were seroepidemiologic, and these were followed by studies in which the organism w ... | 2002 | 11781264 |
| newly characterized species-specific immunogenic chlamydophila pneumoniae peptide reactive with murine monoclonal and human serum antibodies. | a monoclonal antibody (mab) directed against an unknown chlamydophila pneumoniae epitope has been characterized, and the respective peptide mimotope has been identified. a murine mab specific for c. pneumoniae was used to select peptides from phage display libraries. the peptides identified from the phage display library clones reacted specifically with the respective target murine mab and with human sera previously identified as having antibody titers to c. pneumoniae. the selected peptide mimo ... | 2002 | 11874892 |
| macrolides for chronic asthma. | asthma is a chronic disease of the airways in which inflammation of the respiratory mucosa plays a crucial role. the mechanisms responsible for the maintaining of this inflammatory response are only partially known and there is evidence that a role could be paid by chronic infection by intracellular pathogens (such as chlamydia pneumoniae). macrolides are antibiotics with both antimicrobial and anti-inflammatory activities and thus their use in asthmatic patients could lead to reduction of the a ... | 2002 | 11869648 |
| evaluation of chlamydia pneumoniae and mycoplasma pneumoniae as etiologic agents of persistent cough in adolescents and adults. | chlamydia pneumoniae and mycoplasma pneumoniae were evaluated as agents of persistent cough in adolescents and adults (n = 491). tests of 473 respiratory specimens by culture or pcr or both identified four episodes (0.8%) of m. pneumoniae-associated illness and no episodes of c. pneumoniae illness, suggesting that these bacteria do not frequently cause persistent cough. | 2002 | 11825984 |
| culture-negative endocarditis due to chlamydia pneumoniae. | we report on the case of a 54-year-old woman diagnosed as having culture-negative endocarditis (clinical and histopathologic evidence compatible with a recent episode of endocarditis). the responsibility of chlamydia pneumoniae in this episode of endocarditis was suggested by a serological study and was then confirmed by the positive results of pcr and in situ hybridization tests with aortic and mitral valves tissues. to our knowledge, this is the first case of endocarditis due to c. pneumoniae ... | 2002 | 11826006 |
| seroepidemiology in chlamydia pneumoniae-- atherosclerosis association. | 2002 | 11812058 | |
| serological markers of chlamydia pneumoniae infection in men and women and subsequent coronary events; the scottish heart health study cohort. | to investigate the relationship between serum markers of chlamydia pneumoniae infection and subsequent coronary events. methods and | 2002 | 11812066 |
| chlamydia pneumoniae and cardiovascular disease. | chlamydia pneumoniae, a respiratory pathogen, has been suggested as a risk factor for cardiovascular disease. epidemiologic data are very controversial. histopathologic and microbiologic studies have established an association between atherosclerosis and presence of c. pneumoniae, consistently finding c. pneumoniae dna and antigens in atherosclerotic arteries. c. pneumoniae has been cultured from atherosclerotic arteries in several centers. an etiologic role for c. pneumoniae in initiation, acce ... | 2002 | 11853655 |
| detection and typing of respiratory adenoviruses in a single-tube multiplex polymerase chain reaction. | a multiplex polymerase chain reaction (pcr) assay that is capable of detecting and typing six serotypes of respiratory adenovirus (ad) was developed, using multiple sets of type-specific primers. the detection of each different serotype depended on distinguishing different numbers and sizes of amplification products on agarose gels following pcr. the multiplex pcr was tested with 26 clinical ad isolates and other respiratory viruses including influenza viruses, parainfluenza viruses, and respira ... | 2002 | 11857530 |
| chlamydia pneumoniae as a respiratory pathogen. | chlamydia pneumoniae is a recently recognized human respiratory pathogen with a unique biphasic life cycle characterized by an obligate intracellular (replicative) and an extracellular (infectious) form of the organism. c. pneumoniae is widely distributed and, via the respiratory route, infects the majority of the world's population. the majority (70%) of acute human c. pneumoniae respiratory tract infections are asymptomatic or only mildly symptomatic but a minority (30%) cause more severe resp ... | 2002 | 11861211 |
| association between interleukin-6 and carotid atherosclerosis in hemodialysis patients. | interleukin-6 (il-6) is associated with cardiovascular complications in general subjects. although blood il-6 is greatly elevated in hemodialysis (hd) patients, the role of il-6 in the advance of atherosclerosis remains to be determined. | 2002 | 11849469 |
| parameters of inflammation and infection in a community based case-control study of coronary heart disease. | increased levels of systemic inflammatory markers appear to be related to coronary heart disease (chd) both in asymptomatic individuals and in subjects with established chd. whether these associations are related to confounding coronary risk factors or are explicable through chronic infectious conditions is not clear. | 2002 | 11849671 |
| discriminative value of serum amyloid a and other acute-phase proteins for coronary heart disease. | we studied the value of serum amyloid a (saa), a first-class acute-phase protein, as a marker for coronary heart disease (chd) in a middle-aged male population. in a working population of 16307 men (age, 35-59 years), 446 cases had a history of chd or prominent q:qs waves on electrocardiogram. for each case, two matched controls were investigated. saa, measured by immunonephelometry, was correlated with other acute-phase proteins, cardiovascular risk factors, and infectious serology markers. saa ... | 2002 | 11849673 |
| recurrent pneumonia due to persistent chlamydia pneumoniae infection. | two cases of recurrent pneumonia due to chlamydia pneumoniae are described. c. pneumoniae was continuously detected from the nasopharynx in both patients by the polymerase chain reaction and/or culture even with appropriate antibiotic therapy during the first episode. after eradication of c. pneumoniae with long-term macrolide therapy, the respiratory symptoms of both patients completely disappeared and no relapse was observed. these data indicate that new treatment strategies may be necessary t ... | 2002 | 11838587 |
| chlamydia pneumoniae infection and atherosclerosis: methodological considerations. | 2002 | 11815446 | |
| development and evaluation of real-time pcr-based fluorescence assays for detection of chlamydia pneumoniae. | chlamydia pneumoniae is an important respiratory pathogen recently associated with atherosclerosis and several other chronic diseases. detection of c. pneumoniae is inconsistent, and standardized pcr assays are needed. two real-time pcr assays specific for c. pneumoniae were developed by using the fluorescent dye-labeled taqman probe-based system. oligonucleotide primers and probes were designed to target two variable domains of the ompa gene, vd2 and vd4. the limit of detection for each of the ... | 2002 | 11825973 |
| chlamydia pneumoniae iga titres and coronary heart disease; prospective study and meta-analysis. | to examine associations between chlamydia pneumoniae iga titres and incident coronary heart disease, and to compare them with associations previously reported between c. pneumoniae igg titres and coronary heart disease. | 2002 | 11846494 |
| characterisation of 20-kda lectin-spermagglutinin from arum maculatum that prevents chlamydia pneumoniae infection of l-929 fibroblast cells. | a novel lectin from the root of arum maculatum was isolated by saline extraction and purified by cold ethanol precipitation and subsequent fractionation on superose 6 column. the lectin named a. maculatum agglutinin is a non-glycosylated protein with 20-kda molecular mass agglutinating human ejaculated spermatozoa, but not human erythrocytes. the agglutination was blocked in the presence of n-acetylneuraminic acid indicating that the lectin is sialoglycoprotein specific. chlamydia pneumoniae str ... | 2002 | 11934571 |
| increased circulating immune complexes in acute stroke: the triggering role of chlamydia pneumoniae and cytomegalovirus. | the mechanisms of immune reaction involved in the pathogenesis and clinical course of acute vascular incidents are still not completely understood. the aim of this study was to examine the presence of immune complexes (ic) in the acute stroke setting and the first month thereafter and to characterize ic by analyzing the contents of chlamydial lipopolysaccharide and anti-cytomegalovirus (cmv) antibodies in ic. | 2002 | 11935040 |
| detection of chlamydia pneumoniae in unexplained pulmonary hypertension. | the pathogenesis of primary pulmonary hypertension is still unclear. the case of a 68-yr-old female patient who complained of recurrent dizzy spells and collapses over a period of 6 weeks and died of global cardiac failure is presented. autopsy revealed severe pulmonary hypertension, slight chronic bronchitis, and bronchiolitis as well as intra-alveolar accumulation of macrophages. chlamydiae were detected within the pulmonary arteries and in intramural and intra-alveolar macrophages by immunofl ... | 2002 | 11843318 |
| atypical pneumonia in children. | 2002 | 11910135 | |
| antibiotics against chlamydia pneumoniae and prognosis after acute myocardial infarction. | there is mounting pathologic and immunologic evidence that chlamydia pneumoniae plays a role in the atherogenic pathway. however, very few clinical studies have supported these findings. | 2002 | 11835034 |
| properties of the glucose-6-phosphate transporter from chlamydia pneumoniae (hptcp) and the glucose-6-phosphate sensor from escherichia coli (uhpc). | the amino acid sequence of the proposed glucose-6-phosphate (glc6p) transporter from chlamydia pneumoniae (hptcp; hexose phosphate transporter [chlamydia pneumoniae]) exhibits a higher degree of similarity to the escherichia coli glc6p sensor (uhpc) than to the e. coli glc6p transporter (uhpt). overexpression of his-uhpc in a uhpt-deficient e. coli strain revealed that the sensor protein is also able to transport glc6p and exhibits an apparent k(m) ((glc6p)) of 25 microm, whereas his-hptcp exhib ... | 2002 | 11914341 |
| elevated interleukin-6 predicts progressive carotid artery atherosclerosis in dialysis patients: association with chlamydia pneumoniae seropositivity. | the cardiovascular mortality rate is unacceptably high in patients with end-stage renal disease (esrd), which suggests an accelerated atherogenic process. the cause(s) of the accelerated atherogenesis in esrd patients are not known, though recent studies suggest that persistent infection, such as chlamydia pneumoniae, and proinflammatory cytokines may contribute. forty-five esrd patients (26 men) aged 51 +/- 2 years was studied at a time-point close to start of dialysis treatment and again after ... | 2002 | 11840367 |
| chlamydia pneumoniae respiratory infection after allogeneic stem cell transplantation. | chlamydia pneumoniae is a common cause of upper and lower respiratory tract infections in immunocompetent patients; however, its role as a respiratory pathogen in immunocompromised hosts has been infrequently recognized. we describe c. pneumoniae lower respiratory tract infection in a 19-year-old male after allogeneic stem cell transplantation. the patient developed fever on day +14, and a subsequent computed tomography scan of the chest revealed a right lateral pleural-based opacity, which was ... | 2002 | 11923709 |
| chlamydial heat shock protein 60 activates macrophages and endothelial cells through toll-like receptor 4 and md2 in a myd88-dependent pathway. | active inflammation and nf-kappab activation contribute fundamentally to atherogenesis and plaque disruption. accumulating evidence has implicated specific infectious agents including chlamydia pneumoniae in the progression of atherogenesis. chlamydial heat shock protein 60 (chsp60) has been implicated in the induction of deleterious immune responses in human chlamydial infections and has been found to colocalize with infiltrating macrophages in atheroma lesions. chsp60 might stimulate, enhance, ... | 2002 | 11801686 |
| [does chronic periodontitis play a role in the pathogenesis of cardiovascular and cerebrovascular diseases?]. | the role of chronic infections in the initiation of atherosclerotic lesions has been vividly discussed in recent years. a possible causal relationship between cardiovascular diseases and infections with, e. g., chlamydia pneumoniae, helicobacter pylori, or herpes viruses had also been established for chronic periodontitis, in particular after discovery of dna of typical periodontal pathogens in atheromatous plaques. especially in longitudinal epidemiologic studies, a low or moderate association ... | 2002 | 11904848 |
| chlamydia pneumoniae iga- and igg antibodies in young survivors of myocardial infarction. a comparison of antibody detection by a microimmunofluorescence test and an enzyme immunoassay. | chronic chlamydia pneumoniae infection is considered as a cardiovascular risk factor and antibodies are commonly analysed by the subjective microimmunofluorescence (mif) test. we wanted to investigate the c. pneumoniae iga- and igg seroprevalence in young survivors of myocardial infarction and matched controls, and to compare the agreement of detecting antibodies between a mif test and an enzyme immunoassay (eia). | 2002 | 11905590 |
| chlamydia pneumoniae and atherosclerosis -- what we know and what we don't. | the clinical manifestations of atherosclerosis include coronary artery disease (cad), stroke, abdominal aortic aneurysm and peripheral vascular disease. world-wide, cad and stroke are the leading causes of death and disability. the recognition of atherosclerosis as an inflammatory disease in its genesis, progression and ultimate clinical manifestations has created an interesting area of vascular research. apart from those well-known traditional risk factors for atherosclerosis, novel and potenti ... | 2002 | 11906495 |
| correlation of chlamydia pneumoniae infection and severity of accelerated graft arteriosclerosis after cardiac transplantation. | chlamydia pneumoniae has been associated with atherosclerosis, although its role in the process is not clearly defined. heart transplant recipients are known to have high titers of antibodies to c. pneumoniae, and the organism has been recovered from the coronary arteries of both transplant recipients and donors. this study evaluated association between c. pneumoniae infection and accelerated graft arteriosclerosis (aga), also known as cardiac allograft vasculopathy (cav), after cardiac transpla ... | 2002 | 11907424 |
| comparison of eleven commercial tests for chlamydia pneumoniae-specific immunoglobulin g in asymptomatic healthy individuals. | the seroprevalence of anti-chlamydia pneumoniae-specific immunoglobulin g (igg) antibodies is high in the adult population. experience is required to perform a microimmunofluorescence test (mif), the current "gold standard" for serological diagnosis, and the assay still lacks standardization. partially automated enzyme-linked immunosorbent assays (elisas) and enzyme immunoassays (eias), which are more standardized and for which the reading of results is less subjective, have been developed. the ... | 2002 | 11980928 |
| modulating airway defenses against microbes. | prevention and treatment of respiratory infections remain an important health care challenge as the us population ages, contains more susceptible or high-risk people, and encounters new pathogens or antibiotic resistant bacteria. reasonably protective vaccines against very common microbes are available for childhood and adult immunization, but, generally, these are underutilized. a broader definition of higher risk individuals is evolving, which will include more for immunization. different appr ... | 2002 | 11981302 |
| antibody reactivity of a standardized human serum protein solution against a spectrum of microbial pathogens and toxins: comparison with fresh frozen plasma. | in this study, we compared a standardized solution of human serum protein (hsp) and fresh frozen plasma (ffp) with regard to the antibody specificity against a number of microbial pathogens and some important pathogenicity factors of bacterial pathogens. due to the clinical use of hsp and ffp for therapeutical plasma exchange, we have chosen a spectrum of microbial pathogens for serological analysis that is critical in clinical settings. with the enzyme-linked immunosorbent assay technique, we c ... | 2002 | 11982956 |
| persistent chlamydiae and chronic arthritis. | urogenital infection with chlamydia trachomatis can lead to development of an acute inflammatory arthritis, and this acute disease becomes chronic in some individuals. research indicates that the organism is present in synovial tissue of patients with chronic disease in a persistent, rather than an actively growing, form. importantly, metabolic and other characteristics of persistent chlamydia differ from those of actively growing bacteria. other studies suggest that chlamydia pneumoniae can be ... | 2002 | 11879531 |
| pcr in diagnosis of infection: detection of bacteria in cerebrospinal fluids. | 2002 | 11986253 | |
| inclusion fluorescent-antibody test as a screening assay for detection of antibodies to chlamydia pneumoniae. | a study was conducted to determine the ability of the inclusion immunofluorescence assay (inclusion ifa) to act as a screening test to detect samples with antibodies to chlamydia pneumoniae; microimmunofluorescence (mif) was used as the "gold standard." in addition, the inclusion ifa was compared using hep-2 cells infected with either c. pneumoniae cm-1 or chlamydia trachomatis serovar e. a total of 331 serum samples representing a range of mif titers were evaluated. the sensitivities of the inc ... | 2002 | 11986260 |
| [anti-c. pneumoniae igg, iga and igm antibodies in patients undergoing coronary artery bypass grafting]. | the aim of the study was to analyse the prevalence of anti-c. pneumoniae specific igg, iga and igm antibodies in patients undergoing coronary artery bypass engraftment. sera of forty-six patients aged from 40 to 74 years (mean 57.3) were examined just before the time of operation. serum samples taken from 21 young healthy blood donors aged from 19 to 28 years (mean 22.4) and 23 sera taken from older blood donors aged 44-60 years (mean 54.7), were used as controls. specific igg, iga and igm serum ... | 2002 | 11957794 |
| a role for neutrophils in asthma? | 2002 | 11959064 | |
| no evidence of parvovirus b19, chlamydia pneumoniae or human herpes virus infection in temporal artery biopsies in patients with giant cell arteritis. | recent studies have suggested that infective agents may be involved in the pathogenesis of giant cell arteritis (gca), in particular chlamydia pneumoniae and parvovirus b19. we investigated temporal arteries from patients with gca for these infections as well as human herpes viruses using the polymerase chain reaction (pcr). | 2002 | 11961176 |
| autoimmunity to human heat shock protein 60, chlamydia pneumoniae infection, and inflammation in predicting coronary risk. | heat shock protein 60 (hsp60) and chlamydia pneumoniae infection have both been associated with cardiovascular diseases. our aim was to study the role of hsp60 antibodies as coronary risk predictors and their association with c pneumoniae infection and inflammation. this was a prospective, nested, case-control study. the cases consisted of 239 middle-aged finnish men who developed myocardial infarction or coronary death during the follow-up. baseline levels of iga and igg antibodies to human-spe ... | 2002 | 11884286 |
| association between chlamydia pneumoniae antibodies and intimal calcification in femoral arteries of nondiabetic patients. | chlamydia pneumoniae, a gram-negative bacterium, has been suggested to be a risk factor for atherosclerosis. calcium is a well-known component of atherosclerotic plaques, but it is uncertain whether infectious agents play a role in the calcification process of the arteries. | 2002 | 11871929 |
| etiology and management of community-acquired pneumonia in asia. | the causative organisms of community-acquired pneumonia, especially in japan and korea, are essentially similar to those in western countries. if there are any differences, these are due to the laboratory tests and criteria used to define pathogenicity. overall, streptococcus pneumoniae is the most frequently occurring pathogen and haemophilus influenzae, mycoplasma pneumoniae, chlamydia pneumoniae and viruses follow. legionella spp. look likely to be low frequency pathogens in asian countries, ... | 2002 | 11964917 |
| analysis of chlamydia pneumoniae growth in cells by reverse transcription-pcr targeted to bacterial gene transcripts. | chlamydia pneumoniae is an obligate intracellular bacterium and has a unique development cycle consisting of an elementary body (eb) and reticular body (rb). ebs survive in extracellular environments as well as infect susceptible host cells. however, ebs display no measurable metabolic activity. in contrast, rbs are metabolically active and can replicate in a host cell but are noninfectious. therefore, analysis of c. pneumoniae growth in infected cells by conventional bacterial culture may not p ... | 2002 | 11874869 |
| [acute polyradiculoneuropathy after chlamydia pneumoniae infection]. | a 36-year-old woman presented acute polyradiculoneuropathy following chlamydia pneumoniae infection. although electrophysiologic studies were normal, clinical features were typical of guillain-barré syndrome (gbs). anti-ganglioside gm1 antibodies were positive. two other cases of gbs following chlamydia pneumoniae infection have been reported, but no specific feature emerges. outcome was good in our patient after intravenous globulin then antibiotic therapy. our case supports the notion that chl ... | 2002 | 11976599 |
| chlamydia pneumoniae seropositivity and the risk of nonarteritic ischemic optic neuropathy. | to determine whether igg antibodies to chlamydia pneumoniae are associated with nonarteritic ischemic optic neuropathy (naion). | 2002 | 11927434 |
| chlamydia pneumoniae infections in patients with community-acquired pneumonia in slovenia. | it is well known that chlamydia pneumoniae is an important respiratory pathogen. in this study, the prevalence of specific antibodies to c. pneumoniae in hospitalized patients with community-acquired pneumonia (943 adult females, 990 adult males and 185 children) was evaluated over a period of 7 y (1993-99). two serum samples were obtained from all of the patients: 1 on admission and the other 3 weeks later. the specimens were tested for c. pneumoniae igg, igm and iga antibodies by means of a mi ... | 2002 | 12030388 |