Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| long-term dynamics of sin nombre viral rna and antibody in deer mice in montana. | infections with hantaviruses in the natural host rodent may result in persistent, asymptomatic infections involving shedding of virus into the environment. laboratory studies have partially characterized the acute and persistent infection by sin nombre virus (snv) in its natural host, the deer mouse (peromyscus maniculatus). however, these studies have posed questions that may best be addressed using longitudinal studies involving sequential sampling of individual wild-caught, naturally infected ... | 2005 | 16244056 |
| hantaviruses are here in india. | 2005 | 16251773 | |
| metabolic activity of macrophages infected with hantavirus, an agent of hemorrhagic fever with renal syndrome. | monocytes/macrophages are thought to play an important role in pathogenesis of viral infections. these cells are involved in distribution and persistence of viruses in the organism and also influence the regulation of immune reactions. the functional and enzymatic activities of macrophages infected with an agent of hemorrhagic fever with renal syndrome were analyzed for the first time. this disease is caused by a virus of the hantavirus genus, the bunyaviridae family. activities of ectoenzymes 5 ... | 2005 | 16266269 |
| [analysis of part of m gene and genotyping for m segment of hantavirus detected from hfrs patients' sera in qingdao region during 2000 - 2003]. | to study the molecular epidemiological characteristics of hantavirus seen during 2000-2003 in qingdao region of shandong province. | 2005 | 16201465 |
| a retrospective study of hantavirus infection in kinmen, taiwan. | in this retrospective study, 140 serum samples collected from 85 scrub typhus-negative patients in kinmen island in 2000 were tested for antibodies to hantavirus using enzyme-linked immunosorbent assay. seven patients (8.23%) were confirmed as having hantavirus infection as demonstrated by increased hantavirus-specific immunoglobulin m and/or immunoglobulin g antibodies in their convalescent serum samples. analysis of indirect immunofluorescence assay showed that seoul type was the etiologic age ... | 2005 | 16211143 |
| hemorrhagic fever with renal syndrome in the pomurje region of slovenia--an 18-year survey. | to determine the etiology of hemorrhagic fever with renal syndrome (hfrs) in the north-eastern part of slovenia (pomurje region) together with demographic, epidemiological and clinical data on 25 patients from this region who were diagnosed and treated at the general hospital in murska sobota between 1986 and 2003. | 2005 | 16053195 |
| quality assurance for the diagnostics of viral diseases to enhance the emergency preparedness in europe. | the threat posed by emerging and re-emerging communicable diseases and, more recently, by the intentional release of infectious agents in a susceptible population, has been receiving considerable attention at the national and international levels. public health efforts to strengthen disease detection, surveillance and control have been intensified. however, clinicians and clinical microbiology laboratories play an important role in the early detection of disease, the identification of the putati ... | 2005 | 16077216 |
| state-by-state incidences of hantavirus pulmonary syndrome in the united states, 1993-2004. | we investigated geographic disparity in numbers of hantavirus pulmonary syndrome (hps) cases in the united states. the 12-year incidences of hps (cases/100,000 for total and rural residents) by state did not parallel the number of cases per state. the state with the greatest overall incidence was new mexico, with montana ranking second. when rural incidence based on rural human population sizes were compared, new mexico also had the highest incidence, but utah, nevada, montana, arizona, and colo ... | 2005 | 16011436 |
| hantaviruses: molecular biology, evolution and pathogenesis. | hantaviruses are tri-segmented negative sense single stranded rna viruses that belong to the family bunyaviridae. in nature, hantaviruses are exclusively maintained in the populations of their specific rodent hosts. in their natural host species, hantaviruses usually develop a persistent infection with prolonged virus shedding in excreta. humans become infected by inhaling virus contaminated aerosol. unlike asymptomatic infection in rodents, hantaviruses cause two acute febrile diseases in human ... | 2005 | 16375712 |
| hantavirus infection. | 2005 | 16267154 | |
| [the renal failure and capillary leak during the acute stage of (dobrava) dob and puu (puumala) infection]. | the target organ for puumala (puu) and dobrava (dob) viruses is the kidney, but the impact on renal function seems far more important in dob infection than in puu infections. aim of study was to estimate the renal failure and capillary leak during the acute stage of dob-infection and puu-infection. 50 patients with serological conformed diagnosis of acute hantavirus infection were included in the study. diuresis, serum urea and creatinine were measured. size of kidneys and presence of ascites wa ... | 2005 | 16018388 |
| [genetics subtypes and distribution of seoul virus in henan]. | to investigate the sub-genotypes and distribution ot seoul virus in henan. | 2005 | 16390005 |
| hantavirus: 'tis the season. | 2005 | 16027428 | |
| development and evaluation of serological assays for detection of human hantavirus infections caused by sin nombre virus. | the hantavirus cardiopulmonary syndrome (hcps) was first recognized in 1993 after a cluster of acute respiratory distress syndrome deaths in the southwestern of the united states. the major causative agent of hcps in north america is the sin nombre virus (snv) carried by the deer mouse peromyscus maniculatus. the first hcps case imported to europe was reported in 2002. | 2005 | 15911448 |
| detection of human hantavirus infections in lithuania. | in europe certain hantaviruses are known to cause hemorrhagic fever with renal syndrome of different severity. the objective of the present investigation was to study the presence of hantavirus infections in lithuania. | 2005 | 15827873 |
| hantavirus infection in thailand: first clinical case report. | this study involved 115 cases of fever of unknown origin (fuo) patients who were admitted to the department of medicine, siriraj hospital from may 1999 to november 2000. among the patient sera screened by elisa for igg hantavirus, five were positive for igg hantavirus-reacting antibodies and eight tested positive for igm hantavirus-reacting antibodies. one serum had both igg and igm antibodies. the patient exhibited acute encephalitic febrile illness, thrombocytopenia, high ast and alt levels, a ... | 2005 | 16124441 |
| habitat factors associated with bank voles (clethrionomys glareolus) and concomitant hantavirus in northern sweden. | puumala virus (puuv), genus hantavirus, causes nephropathia epidemica, a mild form of hemorrhagic fever with renal syndrome in humans. in this study, bank voles, the natural reservoir of puuv, were captured at locations of previous human puuv exposure and paired controls within a region of high incidence in northern sweden. the aim of the study was to evaluate the influence of environmental factors on the abundance of bank voles and the occurrence of puuv. the total number of voles and the numbe ... | 2005 | 16417427 |
| [hantavirus nephropathy]. | 2005 | 16392314 | |
| larger than usual increase in cases of hantavirus infections in belgium, france and germany, june 2005. | 2005 | 16785666 | |
| increased hantavirus infections in luxembourg, august 2005. | 2005 | 16785690 | |
| nucleocapsid protein of cell culture-adapted seoul virus strain 80-39: analysis of its encoding sequence, expression in yeast and immuno-reactivity. | seoul virus (seov) is a hantavirus causing a mild to moderate form of hemorrhagic fever with renal syndrome that is distributed mainly in asia. the nucleocapsid (n) protein-encoding sequence of seov (strain 80-39) was rt-pcr-amplified and cloned into a yeast expression vector containing a galactose-inducible promoter. a survey of the pattern of synonymous codon preferences for a total of 22 n protein-encoding hantavirus genes including 13 of seov strains revealed that there is minor variation in ... | 2005 | 15744561 |
| [outbreak of hemorrhagic fever with renal syndrome in the ulyanovsk region]. | 2005 | 15801222 | |
| enhancing dna vaccine potency against hantavirus by co-administration of interleukin-12 expression vector as a genetic adjuvant. | the heavy incidence and mortality of hemorrhagic fever with renal syndrome, as well as no specific drugs in curing the disease, clearly indicate the need for development of the more effective hantavirus vaccine. refining the dna vaccination strategy to elicit more clinically efficacious immune responses is now under intensive investigation. in the present study, we examined the effects of using an interleukin-12 expression plasmid as a genetic adjuvant to enhance the immune responses induced by ... | 2005 | 15740670 |
| [emerging respiratory infections caused by pneumotropic viruses]. | 2005 | 15915382 | |
| the hantavirus nucleocapsid protein recognizes specific features of the viral rna panhandle and is altered in conformation upon rna binding. | hantaviruses are tripartite negative-sense rna viruses and members of the bunyaviridae family. the nucleocapsid (n) protein is the principal structural component of the viral capsid. n forms a stable trimer that specifically recognizes the panhandle structure formed by the viral rna termini. we used trimeric glutathione s-transferase (gst)-n protein and small rna panhandles to examine the requirements for specific recognition by sin nombre hantavirus n. trimeric gst-n recognizes the panhandles o ... | 2005 | 15650206 |
| tula hantavirus triggers pro-apoptotic signals of er stress in vero e6 cells. | tula virus is a member of the hantavirus genus of the family bunyaviridae. viruses of this family have an unusual pattern of intracellular maturation at the er-golgi compartment. we recently found that tula virus, similar to several other hantaviruses, is able to induce apoptosis in cultured cells [li, x.d., kukkonen, s., vapalahti, o., plyusnin, a., lankinen, h., vaheri, a., 2004. tula hantavirus infection of vero e6 cells induces apoptosis involving caspase 8 activation. j. gen. virol. 85, 326 ... | 2005 | 15708603 |
| recombinant tula hantavirus shows reduced fitness but is able to survive in the presence of a parental virus: analysis of consecutive passages in a cell culture. | tula hantavirus carrying recombinant s rna segment (rectulv) grew in a cell culture to the same titers as the original cell adapted variant but presented no real match to the parental virus. our data showed that the lower competitiveness of rectulv could not be increased by pre-passaging in the cell culture. nevertheless, the recombinant virus was able to survive in the presence of the parental virus during five consecutive passages. the observed survival time seems to be sufficient for transmis ... | 2005 | 15725355 |
| interactions and trafficking of andes and sin nombre hantavirus glycoproteins g1 and g2. | this study was designed to investigate the trafficking of andes virus (andv) and sin nombre virus (snv) glycoproteins and to determine if andv or snv glycoproteins g1 and g2 could be substituted for each other while still retaining normal trafficking. trafficking of hantaan virus (hntv) and snv glycoproteins has been studied and conflicting results were published regarding the golgi targeting of g1 and g2 when expressed individually. the results reported in this manuscript suggest that both snv ... | 2005 | 15629773 |
| epizootiology of sin nombre and el moro canyon hantaviruses, southeastern colorado, 1995-2000. | sin nombre virus (snv) is an etiologic agent of hantavirus pulmonary syndrome. to better understand the natural history of this virus we studied population dynamics and temporal pattern of infection of its rodent hosts in southeastern colorado (usa) from 1995 to 2000. we present evidence for the presence of two hantaviruses, snv in deer mice (peromyscus maniculatus) and el moro canyon virus in western harvest mice (reithrodontomys megalotis), at our study sites. sin nombre virus appeared only sp ... | 2005 | 15827206 |
| andes virus stimulates interferon-inducible mxa protein expression in endothelial cells. | mxa is a cellular protein activated in cells treated with type i interferons. mxa protein is a member of the dynamin superfamily of large guanosine triphosphatases. a unique property of mx1 gtpases is their antiviral activity against a wide range of rna viruses. replication of several hantavirus strains is inhibited in cells constitutively expressing mxa protein. we have found that andes virus (andv) infection up regulates transcription of mxa rna and expression of mxa protein in human endotheli ... | 2005 | 15602733 |
| [expression of hsp70 in human umbilical vein endothelial cells induced by hantavirus]. | to study stress response in human umbilical vein endothelial cells (huvec) infected with hantavirus (htv). | 2005 | 15629073 |
| pathogenic hantaviruses bind plexin-semaphorin-integrin domains present at the apex of inactive, bent alphavbeta3 integrin conformers. | the alphavbeta3 integrins are linked to human bleeding disorders, and pathogenic hantaviruses regulate the function of alphavbeta3 integrins and cause acute vascular diseases. alphavbeta3 integrins are present in either extended (active) or dramatically bent (inactive) structures, and interconversion of alphavbeta3 conformers dynamically regulates integrin functions. here, we show that hantaviruses bind human alphavbeta3 integrins and that binding maps to the plexin-semaphorin-integrin (psi) dom ... | 2005 | 15657120 |
| hantavirus pulmonary syndrome in central bolivia: relationships between reservoir hosts, habitats, and viral genotypes. | in august 2002, two cases of hantavirus pulmonary syndrome (hps) were confirmed in mineros and concepcion, within the santa cruz department of bolivia. extensive alteration of the native ecosystem, from dense forest to pasture or sugarcane, had occurred in both regions. an ecologic assessment of reservoir species associated with the human disease identified a single hantavirus antibody-positive oligoryzomys microtis from mineros and three hantavirus antibody-positive calomys callosus from concep ... | 2005 | 15728866 |
| new ecological aspects of hantavirus infection: a change of a paradigm and a challenge of prevention--a review. | in the last decades a significant number of so far unknown or underestimated pathogens have emerged as fundamental health hazards of the human population despite intensive research and exceptional efforts of modern medicine to embank and eradicate infectious diseases. almost all incidents caused by such emerging pathogens could be ascribed to agents that are zoonotic or expanded their host range and crossed species barriers. many different factors influence the status of a pathogen to remain unn ... | 2005 | 15744574 |
| hantaviruses in central south america: phylogenetic analysis of the s segment from hps cases in paraná, brazil. | we sequenced the complete s segments of hantaviruses detected from 12 hps patients living in southern of brazil. samples were obtained from patients diagnosed in different years, in distinct areas, and with a broad spectrum of clinical signs. despite these differences, all the s proteins of hantavirus from paraná were identical, except for one amino acid substitution. phylogenetic analyses of the complete s segment nucleotide and amino acid sequences indicated that hantaviruses from paraná form ... | 2005 | 15977228 |
| community-acquired pneumonia: new facets of an old disease--hantavirus pulmonary syndrome. | it seems that with climatic and geoecologic changes, hantaviruses have re-emerged as human pathogens related to increases in interaction between humans and rodent reservoirs. infection with snv in north america and the andes virus in south america can produce infection manifest initially as a flu-like illness. in the setting of a history of possible exposure to rodents or their excreta, clinical symptoms and laboratory clues such as thrombocytopenia should raise the suspicion of hps. clinical de ... | 2005 | 15763221 |
| potential importance of error catastrophe to the development of antiviral strategies for hantaviruses. | hantaviruses represent an important and growing source of disease emergence in both established and developing countries. the new world hantaviruses have been touted as potential biological weapons because of their lethality to humans and high infectivity as an aerosol. it is also important to acknowledge the threat that hantaviruses can represent to us troops that operate in a foreign territory endemic for hantavirus infection, as was demonstrated in the korean war. effective vaccines, immunoth ... | 2005 | 15649565 |
| [expression and genetic immunization of hantaan virus g2 recombinant adenovirus]. | to express hantaan virus(htnv) envelope glycoprotein g(2) recombinant adenovirus(adeno-g(2)) in vero e6 cells and explore its property of inducing immune response. | 2005 | 15989780 |
| newly recognized hantaviruses associated with hantavirus pulmonary syndrome in northern brazil: partial genetic characterization of viruses and serologic implication of likely reservoirs. | following the occurrence of the first laboratory-confirmed cases of hantavirus pulmonary syndrome (hps) in maranhao state, brazil, rodents were trapped and rodent materials screened by elisa for antibodies to sin nombre and andes hantaviruses. antibody-positive samples were tested by rt-pcr, amplified products were sequenced, and phylogenetic trees were constructed for comparison with known hantaviruses. from 104 rodent blood samples collected (40 bolomys lasiurus, 52 holochilus sciureus, 12 oli ... | 2005 | 15815145 |
| clinical sin nombre hantaviral infections in children. | 2005 | 15818300 | |
| a hantavirus nucleocapsid protein segment exposed on hepatitis b virus core particles is highly immunogenic in mice when applied without adjuvants or in the presence of pre-existing anti-core antibodies. | hepatitis b virus (hbv) core particles carrying the amino-terminal 120 amino acids (aa) of the nucleocapsid (n) protein of the hantaviruses dobrava, hantaan or puumala have been demonstrated to be highly immunogenic in mice when complexed with adjuvants. here we demonstrate that even without adjuvant, these chimeric particles induced high-titered, and strongly cross-reactive n-specific antibody responses in balb/c and c57bl/6 mice. the induced n-specific antibodies represented all igg subclasses ... | 2005 | 15917119 |
| acute sin nombre hantavirus infection complicated by renal failure requiring hemodialysis. | 2005 | 15887441 | |
| essential amino acids of the hantaan virus n protein in its interaction with rna. | the nucleocapsid (n) protein of hantavirus encapsidates viral genomic and antigenomic rnas. previously, deletion mapping identified a central, conserved region (amino acids 175 to 217) within the hantaan virus (htnv) n protein that interacts with a high affinity with these viral rnas (vrnas). to further define the boundaries of the rna binding domain (rbd), several peptides were synthesized and examined for the ability to bind full-length s-segment vrna. peptide 195-217 retained 94% of the vrna ... | 2005 | 16014963 |
| hantavirus infection in thailand: first clinical case report. | this study involved 115 cases of fever of unknown origin (fuo) in patients who were admitted to the department of medicine, siriraj hospital from may 1999 to november 2000. among the patient sera screened by elisa for igg hantavirus, five were positive for igg hantavirus-reacting antibodies and eight tested positive for igm hantavirus-reacting antibodies. one serum had both igg and igm antibodies. the patient exhibited acute encephalitic febrile illness, thrombocytopenia, high ast and alt levels ... | 2005 | 15906672 |
| inactivation of hantaan virus-containing samples for subsequent investigations outside biosafety level 3 facilities. | the potential risk of accidental infection by hantaviruses in a clinical or research laboratory necessitates special precautionary measures. a biosafety program must address handling and disposal of infectious materials as well as appropriate virus inactivation or depletion procedures to permit necessary further processing of specimens outside the biosafety level 3 laboratory. | 2005 | 15920350 |
| [nephropathia caused by hantavirus puumala: a case report]. | we present a patient from germany with hantavirus infection, admitted in the emergency room of our hospital, with fever, thrombocytopenia, acute renal failure, oliguria, mild proteinuria and hematuria. percutaneous renal biopsy revealed an acute interstitial nephritis without medulla haemorrhages. the virus infection confirmation was made by detection of igm against hantavirus puumala. this infection should be considered in patients with thrombocytopenia, fever and acute renal failure, over all ... | 2005 | 15912658 |
| hfrs causing hantaviruses do not induce apoptosis in confluent vero e6 and a-549 cells. | hantaviruses are known to cause little or no cytopathic effect in vitro, but have been suggested to cause apoptosis. to determine whether different hantaviruses would induce apoptosis to varying degrees, confluent vero e6 cells were infected with the hemorrhagic fever with renal syndrome (hfrs) causing viruses hantaan, dobrava, saaremaa, and puumala. however, no difference was found in the percentage of adherent cells, or of cells with condensed nuclei, between non-infected and virus-infected ce ... | 2005 | 15834879 |
| ribavirin trials and hantavirus--what we should not conclude. | 2005 | 15844085 | |
| [the epizootological and virological characteristics of a natural hantavirus infection focus in the subtropic zone of the krasnodarsk territory]. | a natural focus of hantavirus infection was detected and examined during the studies conducted in 2000-2002 around the sochi (the western spurs of the great caucasus ridge, which descended to the black sea (the krasnodar territory of russia). at least 4 rodent species, such as microtus majori, a. (s.) ponticus, a. agrarius, a. (s.) ciscaucasicus, were shown to participate in the circulation of hantaviruses. a comparative analysis of the nucleotide sequences of genomic s- and m-segments of hantav ... | 2005 | 16078428 |
| peptide antagonists that inhibit sin nombre virus and hantaan virus entry through the beta3-integrin receptor. | specific therapy is not available for the treatment of hantavirus cardiopulmonary syndrome caused by sin nombre virus (snv). the entry of pathogenic hantaviruses into susceptible human cells is dependent upon expression of the alpha(v)beta(3) integrin, and transfection of human beta(3) integrin is sufficient to confer infectibility onto cho (chinese hamster ovary) cells. furthermore, pretreatment of susceptible cells with anti-beta(3) antibodies such as c7e3 or its fab fragment reopro prevents h ... | 2005 | 15919886 |
| [diagnostic tests: hantavirus]. | 2005 | 16111261 | |
| variability of g1 gene of hantaviruses occurring in the hubei province, p.r. china from 1985 to 2000. | we studied variability of g1 gene of hantaviruses occurring in the hubei province, p.r. china. serum samples were collected from 229 patients with hemorrhagic fever with renal syndromes (hfrs) during 1985--1989 and 1996--2000 and were tested by rt-pcr for the presence of hantaan and seoul viruses (htnvs, seovs) and by restriction fragment length polymorphism (rflp) analysis for the respective pattern. out of 229 sera 166 (72.5%) were hantavirus-positive by rt-pcr, including 124 from 1985--1989 a ... | 2005 | 15929399 |
| [infection due to hantavirus and other rodent-borne viruses]. | the term "robovirus" (rodent-borne virus) refers to viruses belonging to the bunyaviridae (genus hantavirus) and arenaviridae families, which are occasionally transmitted to human beings from rodents, their natural hosts. hantaviruses cause two human diseases: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. arenaviruses produce hemorrhagic fevers or acute central nervous system disease in humans. this article reviews the biology, epidemiology, pathogenesis, clinical feat ... | 2005 | 16185565 |
| norway rat population in baltimore, maryland, 2004. | norway rats are reservoirs for several zoonotic agents, including hantaviruses, and are implicated in the transmission of pathogens to humans in urban environments. the rat population of baltimore, maryland was estimated from surveys in 1949 and again in 1952, but has not been evaluated for more than 50 years. previously identified sociodemographic risk factors for rat infestation, including median income, human density, and percentage of rental properties, were used to categorize census block g ... | 2005 | 16187901 |
| hanta hemorrhagic fever with renal syndrome: a case report and review. | hantavirus infection is seldom reported in taiwan. the spectrum of clinical severity ranges from mild to severe and may cover hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome (hfrs). we report a case of hfrs in a 24-year-old soldier presenting with fever, chills, abdominal pain and generalized myalgia. his clinical course progressed through febrile, hypotensive, oliguria and polyuria phases. hantavirus infection was proven by serology at the second hospital week. the patie ... | 2005 | 15986074 |
| [genotype of isolated strain of hantavirus in liaoning area]. | to isolate hantavirus and to genotype isolated strains of hantavirus (sy 13) in liaoning province. | 2005 | 16201470 |
| [increase of hantavirus infections in france, 2003]. | hantaviral infections causing hemorrhagic fever with renal syndrome are endemic in north eastern france. humans are contaminated by the inhalation of aerosols contaminated by rodent faeces. in february 2003, the national reference centre (nrc) for hemorrhagic fevers detected an increased number of cases. an investigation was carried out to confirm the outbreak and take appropriate control measures. | 2005 | 15780895 |
| cross-species transfer of viruses: implications for the use of viral vectors in biomedical research, gene therapy and as live-virus vaccines. | all living organisms are continuously exposed to a plethora of viruses. in general, viruses tend to be restricted to the natural host species which they infect. from time to time viruses cross the host-range barrier expanding their host range. however, in very rare cases cross-species transfer is followed by the establishment and persistence of a virus in the new host species, which may result in disease. recent examples of viruses that have crossed the species barrier from animal reservoirs to ... | 2005 | 15986492 |
| hantavirus gc glycoprotein: evidence for a class ii fusion protein. | hantavirus cell entry is promoted by its envelope glycoproteins, gn and gc, through cell attachment and by fusion between viral and endosomal membranes at low ph. however, the role of gn and gc in receptor binding and cell fusion has not yet been defined. in this work, a sequence presenting characteristics similar to those of class ii fusion peptides (fps) of alphavirus e1 and flavivirus e proteins is identified within the hantavirus gc glycoprotein. a three-dimensional comparative molecular mod ... | 2005 | 16227214 |
| [hantavirus infections]. | hantaviruses are cosmopolite anthropozoonosis considered as an emerging disease. four pathogenic types for humans and part of the bunyaviridae species are hosted by rodents and have been isolated: the sin nombre virus responsible for the severe american respiratory form; the hantaan and seoul viruses responsible for hemorrhagic fevers with renal syndrome (hfrs) of severe to moderate expression in asia and also in the balkans; the puumala virus responsible for hfrs of moderate expression or the s ... | 2005 | 15859577 |
| are humans infected by hantaviruses in australia? | hantavirus antibody-positive rodents have been found across australia although, to date, there are no reports of infections in humans. this could be due to misdiagnosis clinically and/or inadequate laboratory technique/skills. there are close trading ties between australia and asian countries as well as our geographical neighbours where both human and rodent infections are found, so importation is a continuing threat. we consider that further sero-epidemiological surveys are warranted among rode ... | 2005 | 16248862 |
| low seroprevalence among farmers from nebraska and vicinity suggests low level of human exposure to sin nombre virus. | 2005 | 15927920 | |
| a pilot study for serological evidence of hantavirus infection in human population in south india. | hantaviruses are rodent-borne viruses of the family bunyaviridae that have been identified as aetiological agents of two human diseases, haemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). there are no reports of hantavirus infections in humans from india, hence this pilot study was undertaken to provide the serological evidence of hantavirus infections in humans in south india. | 2005 | 16251777 |
| diffusion and home range parameters from rodent population measurements in panama. | simple random walk considerations are used to interpret rodent population data collected in hantavirus-related investigations in panama regarding the short-tailed cane mouse, zygodontomys brevicauda. the diffusion constant of mice is evaluated to be of the order of (and larger than) 200 meters squared per day. the investigation also shows that the rodent mean square displacement saturates in time, indicating the existence of a spatial scale which could, in principle, be the home range of the rod ... | 2005 | 15998498 |
| human and rodent humoral immune responses to andes virus structural proteins. | in the present work we identified b-cell epitopes recognized by sera of humans and rodents naturally infected with andes virus, a hantavirus present in chile and argentina. analysis of patient and rodent sera with overlapping peptides revealed 21 human and rodent epitopes on the three structural proteins. whereas in the nucleoprotein the region comprising aa 248-260 was shown to be the key determinant of human sera, the major antigenic site of rodent antibody reactivity is located at aa 326-338. ... | 2005 | 15780882 |
| [rodents as the vectors of infective agents in the natural foci of infections in the moscow megapolis]. | this work deals with the results of 40-year observations on the circulation of infective agents in the natural foci of infections (tularemia, leptospirosis, hemorrhagic fever with renal syndrome) among rodents and other small mammals in the territory of the moscow. the monitoring of their frequency and the infection rates remains the main effective measure for the prophylaxis of dangerous infections among the population of the megapolis. | 2005 | 16279545 |
| hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties. | in recent years important progress has been made studying the nucleocapsid (n) protein of hantaviruses. the n protein presents a good example of a multifunctional viral macromolecule. it is a major structural component of a virion that encapsidates viral rna (vrna). it also interacts with the virus polymerase (l protein) and one of the glycoproteins. on top of these "house keeping" duties, the n protein performs interactive "ambassadorial" functions interfering with important regulatory pathways ... | 2005 | 15931462 |
| distribution and abundance of sigmodontine rodents in relation to hantavirus in neuquén, argentina. | in order to estimate spatial distribution, temporal variation, and prevalence of andes hantavirus antibody in the rodent community, and especially in oligoryzomys longicaudatus populations, four different ecosystems were trapped seasonally between spring 2001 and winter 2002 in neuquen, northwestern argentinean patagonia. five peridomestic settings were sampled within the same period. the rodent o. longicaudatus had the widest distribution in neuquen, as it was the only species captured at every ... | 2005 | 16007965 |
| a preliminary study of the patterns of sin nombre viral infection and shedding in naturally infected deer mice (peromyscus maniculatus). | deer mice (peromyscus maniculatus) were trapped in southern manitoba, canada and tested for evidence of sin nombre virus infection. viral genome was amplified from tissues as well as saliva/oropharyngeal fluid, and urine samples were collected from seropositive animals. detection of viral rna in tissue samples and excreta/secreta from mice suggest that differences may exist between naturally infected rodents with respect to viral shedding. | 2005 | 16011428 |
| central european dobrava hantavirus isolate from a striped field mouse (apodemus agrarius). | dobrava virus (dobv) is a hantavirus that causes hemorrhagic fever with renal syndrome (hfrs) in europe. it is hosted by at least two rodent species, apodemus flavicollis and a. agrarius. according to their natural hosts they form the distinct genetic lineages dobv-af and dobv-aa, respectively. we have now established a dobv isolate named slovakia (sk/aa) from an a. agrarius animal captured in slovakia. the complete s and m and partial l segment nucleotide sequences of the new isolate were deter ... | 2005 | 15956394 |
| [addition of an arterio-venous shunt during veno-arterial extracorporeal life support in a patient with hantavirus pulmonary syndrome]. | a subgroup of patients infected with the hantavirus develops a pulmonary syndrome (hps) characterized by severe acute respiratory failure and myocardial depression, that has a high mortality rate. extracorporeal life support (ecls) could be a valuable therapeutic tool in such patients. we report a 24 years old male with hps that was successfully managed when an arterio-venous shunt was added to a conventional veno-arterial ecls technique. precise criteria have been developed to predict which pat ... | 2005 | 16341389 |
| clinical survey of hantavirus in southern brazil and the development of specific molecular diagnosis tools. | hantavirus pulmonary syndrome (hps) is an emerging disease caused by an increasing number of distinct hantavirus serotypes found worldwide. it is also a very severe immune disease. it progresses quickly and is associated with a high mortality rate. at the prodrome phase, hantavirosis symptoms can resemble those of other infectious diseases such as leptospirosis and influenza. thus, prognosis could be improved by developing a rapid and sensitive diagnostic test for hantavirus infection, and by im ... | 2005 | 15964966 |
| regulation of rodent-borne viruses in the natural host: implications for human disease. | prevalence and transmission rates of rodent-borne viruses within host populations vary in time and space and among host-virus systems. improving our understanding of the causes of these variations will lead to a better understanding of changes in disease risk to humans. the regulators of prevalence and transmission can be categorized into five major classes: (1) environmental regulators such as weather and food supply affect transmission rates through their effect on reproductive success and pop ... | 2005 | 16355867 |
| l protein, the rna-dependent rna polymerase of hantaviruses. | l protein of hantaviruses is the rna transcriptase and replicase that transcribes mrnas and replicates the genomic rna using antigenomic rna as an intermediate. it also appears to have endonuclease activity. in this review, the current knowledge on the hantavirus l protein is presented including sequence motifs conserved in rna polymerases, mechanisms of rna synthesis and also the most recent findings on homologous rna recombination and membrane association. | 2005 | 15503219 |
| delayed viremia and antibody responses in puumala hantavirus challenged passively immunized cynomolgus macaques. | no specific therapy is currently available against hemorrhagic fever with renal syndrome (hfrs) or hantavirus pulmonary syndrome. in order to study if passive immunization could inhibit hantavirus infection and/or symptoms, we inoculated two cynomolgus macaques with neutralizing monoclonal antibodies and subsequently challenged them with wild-type puumala virus (puuv), recently shown to induce typical signs of milder hfrs in cynomolgus macaques. although viral load and antibody titers did not di ... | 2005 | 15449139 |
| cellular entry of hantaan virus a9 strain: specific interactions with beta3 integrins and a novel 70kda protein. | cellular entry of pathogenic hantaviruses had been shown to be mediated by beta3 integrins. however, no direct evidence exists that hantavirus binds to beta3 integrins, and integrin beta3 subunit is not expressed on some cells permissive to hantavirus infection. in this report, utilizing beta3-integrin-transfected cho cells, we demonstrated that integrin beta3 subunit renders cho cells susceptible to chinese hantaan virus (htn) strain a9 (isolated in china), and the viral infection was correspon ... | 2006 | 16310165 |
| replication and immunoactivity of the recombinant peromyscus maniculatus cytomegalovirus expressing hantavirus g1 glycoprotein in vivo and in vitro. | previously, we have shown that cmv isolated from deer mouse could be used in vivo and in vitro to express sin nombre virus (snv) glycoprotein g1 in deer mice [rizvanov aa, van geelen ag, morzunov s, et al. generation of a recombinant cytomegalovirus for expression of a hantavirus glycoprotein. j.virol. 2003;77(22):12203-10]. in this report, we further characterize replication of wild-type (wt) and recombinant peromyscus cmv (pcmv) in vivo and in vitro using realtime pcr, and infectious center as ... | 2006 | 16125285 |
| hantavirus cardiopulmonary syndrome: immune response and pathogenesis. | hantaviruses are emerging viruses in the americas that cause cardiopulmonary syndrome with high lethality. the intense cellular immune response to hantavirus alters normal endothelial cell barrier functions and seems to be harmful to the host. on the other hand, the humoral immune response seems to be essential for recovery from infection. | 2006 | 16793309 |
| mathematical models for hantavirus infection in rodents. | hantavirus pulmonary syndrome is an emerging disease of humans that is carried by wild rodents. humans are usually exposed to the virus through geographically isolated outbreaks. the driving forces behind these outbreaks is poorly understood. certainly, one key driver of the emergence of these viruses is the virus population dynamics within the rodent population. two new mathematical models for hantavirus infection in rodents are formulated and studied. the new models include the dynamics of sus ... | 2006 | 16794943 |
| genetic analysis of puumala hantavirus strains from austria. | sequences of the small (s) and the medium (m) genome segments of puumala hantavirus (puuv) were recovered from bank voles clethrionomys glareolus trapped at 2 locations, klippitztörl (carinthia) and ernstbrunn (lower austria). lung tissue samples from 12 rodents earlier found hantavirus antibody-positive were further screened for the presence of hantaviral n-antigen using immunoblotting. rna purified from 7 n-ag-positive samples was subjected to the reverse transcription-polymerase chain reactio ... | 2006 | 16798703 |
| emergency medicine and the public's health: emerging infectious diseases. | in recent years, multiple global forces have contributed to the emergence and widespread distribution of previously unknown disease entities. this article discusses ebola virus, west nile virus, and hantavirus as representative emerging infectious diseases. smallpox is discussed along with concerns about the safety of the smallpox vaccine, given the uncertain risk of bioterrorism and smallpox exposure. ed physicians must become familiar with the presentation, management, and public health impact ... | 2006 | 16982350 |
| clinical and laboratory findings related to a favorable evolution of hantavirus pulmonary syndrome. | the medical records of 27 patients with hantavirus pulmonary syndrome were analyzed according to the need for invasive mechanical ventilation in relation to the following data up on hospital admission: age, gender, fever, cough, dyspnea, systolic arterial blood pressure, heart rate, levels of hemoglobin, hematocrit, leukocytes, lymphocytes, platelets, creatinine and arterial blood gases. the volume infused during the first 24 hours after admission, the use of inotropic agents, the use of cortico ... | 2006 | 16906244 |
| hemorrhagic fever with renal syndrome complicated with pregnancy: a case report. | hantaviruses cause two forms of human disease: hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome. hantavirus infection can occur in pregnant women and it can have an influence on the maternal and fetal outcomes, although this is a rare finding even in endemic areas. we describe here a recent case of hfrs complicating pregnancy. | 2006 | 16913449 |
| [first serological evidence of hantavirus infection in rodents in colombia]. | determining hantavirus infection prevalence in rodents in the c6rdoba department, colombia. | 2006 | 16925117 |
| evaluation of promed-mail as an electronic early warning system for emerging animal diseases: 1996 to 2004. | to identify emerging animal and zoonotic diseases and associated geographic distribution, disease agents, animal hosts, and seasonality of reporting in the program for monitoring emerging diseases (promed)-mail electronic early warning system. | 2006 | 17014355 |
| drotrecogin alpha (activated) in two patients with the hantavirus cardiopulmonary syndrome. | hantavirus cardiopulmonary syndrome (hcps) is associated with rapid cardiopulmonary collapse from endothelial injury, resulting in massive capillary leak, shock and severe hypoxemic respiratory failure. to date, treatment remains supportive and includes mechanical ventilation, vasopressors and extracorporeal membrane oxygenation, with mortality approaching 50%. two hcps survivors initially given drotrecogin alpha (activated) (daa) for presumed bacterial septic shock are described. vasoactive med ... | 2006 | 16896430 |
| a pseudotype vesicular stomatitis virus containing hantaan virus envelope glycoproteins g1 and g2 as an alternative to hantavirus vaccine in mice. | we examined whether a vesicular stomatitis virus (vsv) pseudotype bearing the hantavirus envelope glycoproteins (gps) g1 and g2 (vsvdeltag*htn) could be used as a safe and effective alternative to native hantavirus. mice were immunized with purified particles of vsvdeltag*htn. after the second immunization, all mice produced anti-gp antibody as detected in elisa and a neutralization test. after the third immunization, the mice were challenged with hantaan virus. neither anti-np antibody producti ... | 2006 | 16426712 |
| serological assays for the detection of human andes hantavirus infections based on its yeast-expressed nucleocapsid protein. | the objective of the study was to develop and evaluate igm and igg elisas and an igg western blot test for the serological detection of human infections with andes virus (andv), the major cause of hantavirus cardiopulmonary syndrome (hcps) in south america. | 2006 | 16428893 |
| microbiological contamination of laboratory mice and rats in korea from 1999 to 2003. | to survey the microbiological contamination of laboratory mice and rats in korea during a 5-year period, we monitored animals housed in mouse and rat facilities with either barrier or conventional systems. at barrier and conventional mouse facilities, the most important pathogen identified was mouse hepatitis virus (mhv), while mycoplasma pulmonis was the most important pathogen at conventional rat facilities. interestingly, hantavirus was recovered from both barrier and conventional mouse facil ... | 2006 | 16508207 |
| dobrava, but not saaremaa, hantavirus is lethal and induces nitric oxide production in suckling mice. | hantaviruses are the causative agents of hfrs and hcps (hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome), two severe, and often fatal human diseases. mortality from hfrs varies between hantaviruses; hantaan and dobrava show the highest, seoul intermediate, and puumala low mortality. saaremaa, genetically closely related to dobrava, is also known to induce hfrs, with low or no mortality. in this study, mice were inoculated with dobrava and saaremaa viruses to test fo ... | 2006 | 16513381 |
| generation of monoclonal antibodies of desired specificity using chimeric polyomavirus-derived virus-like particles. | foreign protein sequences presented on hamster polyomavirus (hapyv) major capsid protein vp1-derived virus-like particles (vlps) have been demonstrated to be highly immunogenic. the current study was aimed to evaluate vp1-derived chimeric vlps as tools for hybridoma technology to generate monoclonal antibodies (mabs) of desired specificity. chimeric vlps containing inserts of different size and origin were used as immunogens. chimeric vlps carrying a 9 amino acid (aa)-long cytotoxic t-cell epito ... | 2006 | 16516908 |
| [study on the association between hantavirus infection and rattus norvegicus]. | to further understand the association of hantavirus (hv) harbored and transmitted in wild brown rats. | 2006 | 16792882 |
| corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by puumala virus infection. | reported here are two cases of hantavirus pulmonary syndrome caused by puumala virus infection, which rapidly resolved after initiation of corticosteroid treatment combined with continuous veno-venous hemodiafiltration. these cases emphasize the role of the inflammatory response in the pathogenesis of hantavirus pulmonary syndrome. | 2006 | 16550348 |
| is there an association of pneumocystis infection with the presence of arena-, hanta-, and poxvirus antibodies in wild mice and shrews in finland? | as part of studies on the nature of the endemic virus infections in natural rodent hosts, the possible association of cyst forms of pneumocystis spp. with the presence of hanta-, cowpox-, and arenavirus antibodies in wild mice (apodemus flavicollis, n=105; apodemus agrarius, n=63; micromys minutus, n=50) and the common shrew (sorex araneus, n=101) was studied in south-central finland. one hantavirus (saaremaa virus, saav) seropositive a. agrarius, and 2 cowpoxvirus (cpxv) seropositive s. araneus ... | 2006 | 16556344 |
| a history of biological disasters of animal origin in north america. | this paper examines past occurrences in north america relevant to the possibility of biological disasters with animal origins. with respect to naturally occurring animal disease outbreaks, north america, while not as adversely affected by epizootics as other regions, has had its fair share of such outbreaks of both 'traditional' and emerging animal diseases. the traditional category includes such diseases as anthrax, classical swine fever, bluetongue, brucellosis, foot and mouth disease, and the ... | 2006 | 16796038 |
| biological control agents elevate hantavirus by subsidizing deer mouse populations. | biological control of exotic invasive plants using exotic insects is practiced under the assumption that biological control agents are safe if they do not directly attack non-target species. we tested this assumption by evaluating the potential for two host-specific biological control agents (urophora spp.), widely established in north america for spotted knapweed (centaurea maculosa) control, to indirectly elevate sin nombre hantavirus by providing food subsidies to populations of deer mice (pe ... | 2006 | 16623730 |
| [full length nucleotide sequence analysis of l and m segments of hantavirus q32 strain gene]. | to study the full length l and m sequence of hantavirus q32 strain gene and explore its molecular characters. | 2006 | 16816865 |
| ten-year prognosis of puumala hantavirus-induced acute interstitial nephritis. | nephropathia epidemica (ne) is a hemorrhagic fever with renal syndrome caused by puumala hantavirus. its long-term prognosis is considered favorable. there are, however, some reports about subsequent hypertension, glomerular hyperfiltration, and proteinuria after previous hantavirus infection. therefore, we studied 36 patients 5 and 10 years after acute ne, with 29 seronegative controls. office blood pressure, ambulatory 24-h blood pressure (abp), glomerular filtration rate (gfr), and proteinuri ... | 2006 | 16641933 |
| a friday afternoon case of apparent anti-glomerular basement nephritis. | 2006 | 16644771 | |
| a new puumala hantavirus subtype in rodents associated with an outbreak of nephropathia epidemica in south-east germany in 2004. | a micro-epidemic of hantavirus infections occurred in lower bavaria, south-east germany, starting in april 2004. while only three cases were registered from 2001 to 2003, a dramatically increased number of clinically apparent human hantavirus infections (n=38) was observed in 2004, plus seven additional cases by june 2005. to determine the reservoir responsible for the infections, a total of 43 rodents were trapped in lower bavaria. serological and genetic investigations revealed that puumala vi ... | 2006 | 16650330 |