Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [burkitt-like lymphoma: diagnosis, clinical features, and response to chemotherapy (author's transl)]. | the burkitt-like lymphoma is extremely rare. it shows a predominance of presentation in abdominal and pelvic sites and an older median age as compared to the endemic burkitt's lymphoma. both are independent prognostic determinants and reflect a poor prognosis. this might be the reason for the low response rate to cytotoxic treatment. cyclophosphamide is a substantial part of any chemotherapeutic regimen used. serum lactic dehydrogenase (ldh) levels are closely correlated with the extent of tumor ... | 1979 | 229308 |
| effect of chloroquine on epstein-barr virus expression. | 1979 | 229421 | |
| guillain-barré syndrome associated with epstein-barr virus in a cytomegalovirus-negative patient. | epstein-barr virus and cytomegalovirus have both been associated with guillain-barré syndrome after antibody investigations in several patients. in the teenage female patient in this present report, guillain-barré syndrome following infectious mononucleosis was associated with sero-conversion against epstein-barr virus but not cytomegalovirus. the findings are consistent with the hypothesis that epstein-barr virus might be an etiological agent for the guillain-barré syndrome and that infection w ... | 1979 | 230116 |
| burkitt's lymphoma cells: membrane properties and surface morphology as seen by scanning electron microscopy. | 1979 | 230393 | |
| comparison of membrane proteins of burkitt's lymphoma and ebv-transformed b lymphoblast cell lines and of con a-activated t lymphocytes and t lymphoblast cell lines. | 1979 | 230395 | |
| infectious mononucleosis. | 1979 | 223111 | |
| sites of sequence variability in epstein-barr virus dna from different sources. | the intracellular epstein-barr virus (ebv) dna present in virus-transformed cells was partly purified from 23 cell lines or biopsies of burkitt lymphoma, nasopharyngeal carcinoma, infectious mononucleosis, or healthy carrier origin. such dna was cleaved in fragments (a-k) of molecular weights between 1 x 10(6) and 30 x 10(6) with restriction enzyme ecori, and these fragments were analyzed by standard methods involving agarose gel electrophoresis, transfer to nitrocellulose filters, and hybridiza ... | 1979 | 223159 |
| epstein-barr virus rna in burkitt tumor tissue. | 1979 | 222455 | |
| infectious mononucleosis. | an up-to-date review of the clinical diagnostic and treatment of infectious mononucleosis, emphasizing on new etiological concepts (epstein-barr virus) and pathogenetic (t and b lymphocytes) interaction is presented. | 1979 | 224362 |
| development of antibodies reactive in antibody-dependent cellular cytotoxicity in infectious mononucleosis. | serial sera from patients with infectious mononucleosis were examined for the emergence of antibodies reactive in antibody-dependent cellular cytotoxicity tests, using epstein-barr virus-superinfected raji cells as targets. for this specific purpose, the antibody-dependent cellular cytotoxicity test proved to be of limited sensitivity because only relatively high serum dilutions can be tested dependably, due to prozone effects at low serum concentrations, and because antibody-dependent cellular ... | 1979 | 222678 |
| persistent infection of a human lymphoblastoid cell line with equine herpesvirus 1. | infection of a human lymphoblastoid cell line (jijoye line derived from a burkitt lymphoma which contains epstein-barr virus) with equine herpesvirus 1, maintained and observed for 53 days, was characterized by the continuous production of infectious extracellular and intracellular virus. maximum virus production correlated with active cell multiplication. less than 15% of the cells possessed viral capsid antigen at any one time. five percent of the cells in the jijoye line possess epstein-barr ... | 1979 | 222688 |
| long-term c-cell-mediated immunity to epstein-barr virus in man. ii. components necessary for regression in virus-infected leukocyte cultures. | regression of eb-virus-induced transformation occurs exclusively in cultures of leukocytes from seropositive donors. studies have shown that the strength of regression could be assayed in terms of the proportion of t cells which must be added to the autologous eb virus-infected t-cell-depleted population in order to establish regression in the culture. the in vitro regression phenomenon was strongly t-cell-dependent but did not require the presence of either monocytes or, as a potential antigeni ... | 1979 | 222690 |
| [c3 receptor expression in lymphocytes]. | 1979 | 224224 | |
| diagnostic aspects of the cytomegalovirus mononucleosis syndrome in previously healthy persons. | the mononucleosis-like syndrome due to cytomegalovirus (cmv) has many clinical features in common with classic epstein-barr virus (ebv) induced infectious mononucleosis (im). the hematologic and hepatic findings in both diseases are identical. diagnosis of the cmv-im syndrome usually can be made on the basis of indirect immunofluorescence for cmv macroglobulins (cmv-igm). ebv virologic tests may also be necessary, as patients with primary ebv infections may have cross-reactions at low titer in t ... | 1979 | 224385 |
| kawasaki disease without epstein-barr virus. | 1979 | 225579 | |
| cytotoxic effect of neocarzinostatin on human lymphoid cells. | effect of a protein antitumor antibiotic, neocarzinostatin (ncs) was examined on epstein-barr virus (ebv)-carrying human lymphoid cell lines and normal human lymphocytes. a marked cytotoxic effect of ncs on umbilical cord lymphocytes freshly transformed by ebv was observed, whereas the cells before transformation were affected only very little by ncs. majority of long-term cultured cell lines were affected only slightly, while shorter-term cultured lines were more susceptible to the effect of nc ... | 1979 | 225845 |
| polyclonal immunoglobulin secretion by human b lymphocytes exposed to epstein-barr virus in vitro. | 1979 | 221572 | |
| lymphocyte activation by the tumor-promoting agent 12-o-tetradecanoylphorbol-13-acetate (tpa). | tpa, a highly active tumor-promoting agent, is an effective mitogen for primate peripheral blood lymphocytes. optimal stimulation of human lymphocytes was obtained 4 days after the addition of tpa at a concentration of 7.5 ng/ml. lymphocyte fractionation experiments demonstrated that both t and b cells incorporated 3h-thymidine significantly in response to tpa. lymphocyte blastogenesis was not due to the reactivation of latent herpesviruses by the tumor promoter, since similar responses to tpa w ... | 1979 | 221578 |
| in vitro transforming activity of epstein-barr virus (ebv). ii. differences between m81 and b95-8 ebv strains. | lymphocytes from 38 human cord blood and 9 adult circulating blood were aliquoted and infected in parallel either with the b95-8 ebv strain (produced by cotton-top marmoset lymphocytes transformed by ebv originating from an infectious mononucleosis line) or with the m81 eb virus (produced by callithrix jacchus marmoset lymphocytes transformed by ebv originating from a nasopharyngeal carcinoma (npc) derived line). significant differences were observed in the lymphoblastoid lines obtained and invo ... | 1979 | 224964 |
| serum glycoproteins and immunoglobulins in nasopharyngeal carcinoma: correlations with epstein-barr virus associated antibodies and clinical tumor stage. | 1979 | 225960 | |
| analysis of early and late epstein-barr virus associated polypeptides by immunoprecipitation. | 1979 | 224588 | |
| enhancement of epstein-barr virus replication in producer cell lines by a combination of low temperature and corticosteroids. | 1979 | 224594 | |
| infectious mononucleosis test performance on cap survey specimens. | the participant performances on 1977 and 1978 infectious mononucleosis survey specimens are tabulated. the various methods utilized gave similar results on negative specimens. commercial reagent kits incorporating differential absorption performed somewhat better on positive specimens than kits without differential absorption. many of the commercial reagent kits performed very poorly on the false postitive specimen. | 1979 | 224693 |
| etiology of liver disease in renal-transplant patients. | the etiology of 72 episodes of liver disease that developed in 62 of 162 renal-transplant recipients was evaluated. infection with hepatitis b virus was a minor problem, and none of our patients had evidence of infection with hepatitis a. cytomegalovirus infection was ubiquitous in the population and probably accounted for many episodes of acute liver disease. this agent's role in causing chronic hepatitis is less secure. infections with other viruses including epstein-barr virus, adenovirus, an ... | 1979 | 224742 |
| cells containing epstein--barr nuclear antigen (ebna) in peripheral blood. | the anti-complement immunofluorescence (acif) method was used to demonstrate ebna in b lymphocytes separated from the peripheral blood of patients with infectious mononucleosis (im) or other diseases. in the acute phase of im of epstein-barr virus (ebv) origin, 0.5--1% of the b lymphocytes proved to be positive in 6 of the 8 patients tested. in two of the positive cases the test was repeated 20 and 26 days, respectively, after clinical symptoms had appeared; the result was negative in both cases ... | 1979 | 225932 |
| [the epstein-barr virus, lymphoma and immunodeficiency state]. | 1979 | 226463 | |
| activation of suppressor t cells during epstein-barr-virus-induced infectious mononucleosis. | infectious mononucleosis is caused by the epstein-barr virus (ebv), an unusual human pathogen because it preferentially infects b lymphocytes and consequently activates them to produce immunoglobulins. when cultures of lymphocytes from patients with infectious mononucleosis were stimulated with polyclonal activators, unseparated cells failed to produce immunoglobulins, whereas purified b cells responded normally. cocultures demonstrated profound suppressor t-cell activity in blood from patients ... | 1979 | 226884 |
| surface markers and size of lymphocytes in human umbilical cord blood stimulated into deoxyribonucleic acid synthesis by epstein-barr virus. | we characterized subpopulations of lymphocytes in human umbilical cord blood which are stimulated into deoxyribonucleic acid synthesis by epstein-barr virus. lymphocytes were examined simultaneously for deoxyribonucleic acid synthesis by autoradiography and for surface markers by rosette formation with sheep erythrocytes or erythrocytes coated with antibody and mouse complement (eac). the subpopulation which incorporated [3h]thymidine after exposure to virus consisted mainly of cells which forme ... | 1979 | 227794 |
| histopathology of nasopharyngeal carcinoma: correlations with epidemiology, survival rates and other biological characteristics. | a total of 363 cases of nasopharyngeal carcinoma (npc) in singapore were classified into squamous cell carcinoma (scc; 73 cases), non-keratinizing carcinoma (nkc; 178 cases) and undifferentiated carcinoma (uc; 172 cases). possible biological differences between these histologic types and between tumors with and without lymphocytic infiltration were investigated by correlations with survival rates and with selected epidemiologic, immunovirologic, and immunogenetic data on the disease. the 5-year ... | 1979 | 225002 |
| epstein-barr virus-specific serum immunoglobulin a as an acute-phase antibody in infectious mononucleosis. | immunoglobulin a (iga) antibodies to epstein-barr virus viral capsid antigen were assayed serially in 19 patients with infectious mononucleosis and in 38 controls. seventy-four percent of infectious mononucleosis patients demonstrated iga antibody, whereas this was found in 13% of controls. this antibody appeared early in infectious mononucleosis and was virtually gone 10 weeks after onset. comparison of iga antibody kinetics was made with igg and igm antibodies to viral capsid antigen, heteroph ... | 1979 | 227922 |
| detection of virus and cellular-determined antigens in situ using [125i]protein a and autoradiography. | the present paper describes the use of [125i]protein a, isolated from staphylococcus aureus, in detecting antigen-antibody complexes by autoradiography on single cells. the method is relatively quick, reproducible, potentially more sensitive than immunofluorescence, and should be useful in combination with conventional radioimmuno-assays. we have used it to detect the cellular expression of igm, kappa, lambda, and beta 2-microglobulin, as well as the expression of epstein-barr virus (ebv)-associ ... | 1979 | 227963 |
| the structure of the termini of the dna of epstein-barr virus. | we have studied the dna of epstein-barr virus (ebv) isolated from the b95-8 strain of that virus (miller and lipman, 1973). when ebv dna is partially digested with lambda-exonuclease and allowed to reanneal, up to 50% of the full-length molecules circularize. the arrangements of nucleotide sequences containing the terminal repeats identified in this circularization experiment have been determined. those fragments of viral dna generated by digestion with restriction endonucleases which are termin ... | 1979 | 225039 |
| the role of viral transformation and cytogenetic changes in viral oncogenesis. | a wide variety of dna viruses and a more restricted family of rna viruses can transform normal cells in vitro. transformation means either immortalization and/or the appearance of certain phenotypic changes. although it has been often inferred that in vitro transformation can be essentially equated with malignant transformation, increasing evidence indicates that the latter, reflected by tumorigenicity in vivo, requires additional cytogenetic changes. the evidence will be reviewed for eb virus-a ... | 1979 | 225148 |
| elevated titer of antibodies to simian sarcoma virus envelope antigen (gp70) and normal response to influenza virus in untreated danish hodgkin's patients. | untreated danish hodgkin's disease (hd) patients and paired age- and sex-matched controls were tested for serum antibodies to epstein-barr virus (ebv), six strains of influenza virus and simian sarcoma virus/simian sarcoma-associated virus [ssv(ssav)] antigens. hd sera showed significantly elevated titers against ebv and both increased incidence and mean titer of antibodies to the envelope glycoprotein of ssv(ssav), whereas testing against the influenza viruses revealed no differences between hd ... | 1979 | 225281 |
| growth of diploid, epstein-barr virus-carrying human lymphoblastoid cell lines heterotransplanted into nude mice under immunologically privileged conditions. | human epstein-barr virus-carrying lymphoid cell lines which have been classified on the basis of studies on clonality and morphological, chromosomal and functional parameters as lymphoblastoid cell lines (lcl) of presumed non-neoplastic origin were inoculated intracerebrally into nude mice. all eighteen of them grew, killing the host mice within 7 to 25 days, except for 2 which grew more slowly. at autopsy, the brain of the nudes was found to be invaded by infiltrating lymphomas. sixteen of thes ... | 1979 | 225282 |
| epstein-barr mononucleosis in older persons. | 1979 | 225388 | |
| an unusual antibody response to epstein-barr virus during infancy. | 1979 | 225393 | |
| herpes simplex virus type 1 infection of isogenic epstein-barr virus genome-negative and -positive burkitt's lymphoma-derived cell lines. | the epstein-barr virus (ebv) genome-negative burkitt's lymphoma-derived cell lines bjab and ramos and their in vitro ebv-converted sublines bjab-b1, bjab-a5, bjab-b95-8, and aw-ramos were infected with high multiplicities of herpes simplex virus type 1 (hsv-1; 10 to 70 pfu/cell). cultures were monitored for cell growth and hsv-1 dna synthesis. ebv-converted bjab cultures were more permissive for hsv-1 infection than bjab cultures. significant cell killing and hsv-1 dna synthesis were observed du ... | 1979 | 225521 |
| dna of epstein-barr virus. v. direct repeats of the ends of epstein-barr virus dna. | previous data indicated that epstein-barr virus dna is terminated at both ends by direct or inverted repeats of from 1 to 12 copies of a 3 x 10(5)-dalton sequence. thus, restriction endonuclease fragments which include either terminus vary in size by 3 x 10(5)-dalton increments (d. given and e. kieff, j. virol. 28:524--542, 1978; s. d. hayward and e. kieff, j. virol. 23:421--429, 1977). furthermore, defined fragments containing either terminus hybridize to each other (given and kieff, j. virol. ... | 1979 | 225546 |
| dna of epstein-barr virus. vi. mapping of the internal tandem reiteration. | epstein-barr virus (b95-8) dna consists of short (10 x 10(6)) and long (87 x 10(6)) unique dna sequences joined by 10 tandem reiterations of a 1.85 x 10(6) dna segment. the reiterated sequence contains bami and bglii sites separated by 4 x 10(5). the 4.5 x 10(5) and 14.0 x 10(5) segments generated by cleavage of the reiterated dna with bami and bglii contain sequences which hybridize to each other, suggesting that the internal tandemly reiterated sequence has a direct or inverted repeat within i ... | 1979 | 225556 |
| studies on an epithelial/burkitt hybrid cell line prepared from a lymphoblastoid cell line with one ebv genome equivalent per cell. | 1979 | 225868 | |
| [igg- and iga-antibodies to the epstein-barr virus in the sera of patients with nasopharyngeal carcinoma in cuba]. | sera from 24 patients with nasopharyngeal carcinoma (npc) and from 60 normal subjects were examined for the presence of igg and iga antibody to various antigens associated with epstein-barr virus (ebv). the results indicate that npc in cuba, like in other countries, was accompanied by high titers of ebv-specific igg antibody the levels of which differed markedly from those in normal subjects. serological activity of the patients differed depending on the stage of the illness and its duration. ge ... | 1979 | 225887 |
| [levels of humoral antibodies to epstein-barr virus in the population of cuba]. | indirect immunofluorescence was used to study the levels of humoral antibodies to capsid (vca) and early (ea) antigens of epstein-barr virus (ebv) in sera of 322 normal subjects living in the province of habana and varying in ages from several months to 93 years. the results suggest that the population of cuba, like in other countries, is widely infected with ebv, although the pattern of spread of this infection has some specific features. in particular, the infection rate of the pediatric popul ... | 1979 | 225888 |
| biological and biochemical observations on isolates of eb virus from the malignant epithelial cells of two nasopharyngeal carcinomas. | foetal, adult seronegative, and cotton-top marmoset lymphocytes have been transformed into cell lines by eb virus from the malignant epithelial cells of two nasopharyngeal carcinomas. the nature of the cell lines was checked by karyotyping and by light and electron microscopy, and the presence of the eb virus genome was demonstrated by immunofluorescence tests. immunofluorescence also showed the incidence of eb virus-producing cells in each line and this was checked by electron microscopy and th ... | 1979 | 226484 |
| inhibition of the in vitro outgrowth of epstein-barr virus-infected lymphocytes by tg lymphocytes. | human t lymphocytes subpopulations from subjects not acutely infected with ebv have been selected and examined for ability to inhibit the outgrowth of autologous b lymphocytes that have undergone in vitro infection with eb virus. the results show that only tg lymphocytes are inhibitory. tg lymphocytes from subjects who are ebv antibody-negative inhibit as well as those from subjects who have ebv antibody. tg lymphocyte populations, as well as other t cell fractions obtained from neonatal subject ... | 1979 | 226628 |
| cellular antiproliferative action exerted by auranofin. | auranofin (af) is a new orally absorbed coordinated gold compound currently undergoing phase i studies for its use in the treatment of rheumatoid arthritis. our investigations with raji lymphoma, hela carcinoma, and ebv-transformed cells indicate af exerts an inhibitory effect on dna, rna, and protein synthesis as assessed by 3h-thymidine, 3h-uridine, and 3h-leucine uptake, respectively. a rapid and persistent dose dependent inhibition of 3h-thymidine uptake was observed at gold concentrations o ... | 1979 | 226702 |
| rheumatoid factor as a cause of positive reactions in tests for epstein-barr virus-specific igm antibodies. | 1979 | 226299 | |
| a virus-free immunogen effective against epstein-barr virus. | 1979 | 226890 | |
| studies on nasopharyngeal carcinoma in the united states: a model for international comparisons. | 1979 | 228896 | |
| oncogenic herpesviruses of nonhuman primates. | 1979 | 228897 | |
| immunologic considerations in the selection of nonhuman primate models for studies of epstein--barr virus-associated diseases in man. | 1979 | 228898 | |
| a review of herpesvirus papio, a b-lymphotropic virus of baboons related to ebv. | 1979 | 228899 | |
| the rescue of epstein--barr virus from primary cultured cells of nasopharyngeal carcinoma. | 1979 | 228891 | |
| dynamics of epstein--barr virus antibody titre in nasopharyngeal carcinoma. | 1979 | 228893 | |
| a lymphoblastoid cell line from an adenosine deaminase deficient patient established by epstein-barr virus. | lymphoblastoid cell lines from a patient with adenosine deaminase (ada) deficiency and his parents were established by epstein-barr virus (ebv). ada activity in the lymphoblastoid cells from the patient was not detectable, while the enzyme activity in the cells from his parents was approximately a half level of the controls'. no inhibitor to ada could be detected in the lymphoblastoid cells from the patient. | 1979 | 227140 |
| effect of 12-o-tetradecanoyl-phorbol-13-acetate on the replication of epstein-barr virus. i. characterization of viral dna. | 1979 | 227161 | |
| epstein--barr virus infection: seroepidemiology in various population groups of the greater montreal area. | 1979 | 228894 | |
| [production of lymphoid tumors in hamsters by direct implantation of human umbilical cord leukocytes. report i. production of lymphoid tumors and culture and their serial transplantation (author's transl)]. | 1979 | 227213 | |
| [production of lymphoid tumors in hamsters by direct implantation of human umbilical cord leukocytes. report ii. cell population analysis of the lymphoid tumors (author's transl)]. | 1979 | 227214 | |
| seroepidemiology of epstein--barr virus-associated diseases--i. a pilot evaluation using a radiometric quantitative complement fixation test. | 1979 | 228895 | |
| deoxyribonuclease activity found in epstein--barr virus producing lymphoblastoid cells. | a deoxyribonuclease activity from epstein--barr (eb) virus producer lymphocyte cell lines which is correlated with viral production and which is not present in virus non-producer or negative lymphocyte cell lines has been purified 220-fold with 20% recovery and characterized. this nuclease copurifies through diethylaminoethylcellulose column chromatography with the eb virus induced deoxyribonucleic acid (dna) polymerase in eb virus producer cells which was recently reported by this laboratory, b ... | 1979 | 227441 |
| interaction of factors associated with cancer of the nasopharynx. | a retrospective study of nasopharyngeal carcinoma (npc) revealed that smoking, working under poor ventilation, use of nasal balms or oil for nasal and throat troubles, use of herbal drugs, and anti-ebv antibody titer were found statistically associated. the dural interactions of these factors to the risk of npc were presented. except in work conditions with poor ventilation and when herbal drugs are used, all the combinations were synergistic. the synergistic actions were especially remarkable w ... | 1979 | 227565 |
| relationship between epstein-barr virus genome number, amount of nuclear antigen, and early antigen inducibility in diploid and tetraploid lymphoma cells of related origin. | in a collection of near-diploid and near-tetraploid raji sublines and somatic raji/raji hybrids a linear relationship was found between the number of epstein-barr virus (ebv) genome copies and the relative amount of ebv-determined nuclear antigen per cell. inducibility of the viral cycle by iododeoxyuridine and by p3hr-1 virus superinfection coulb be related to the number of resident ebv genome copies per haploid target cell. the implications of these findings are discussed. | 1979 | 227812 |
| [diagnostic evaluation of anti-ebv(vca and ea) antibody titration in patients with nasopharyngeal carcinoma (author's transl)]. | 1979 | 228017 | |
| the effects of mitogens on the expression of epstein-barr virus antigens in human lymphoid cell lines. | treatment of human lymphoblastoid cells with either phytohemagglutinin (pha), concanavalin a, staphylococcus protein a, or polyinosinic acid-polycytidylic acid, in combination with 5-iodo-2' deoxyuridine (iudr) markedly increased the expression of epstein-barr virus (ebv) early antigen (ea) relative to iudr alone. such treatment did not, however, modify the production of virus capsid antigen in any of the lymphoid cell lines tested. the effect of pha on ea induction in raji cells was not accompa ... | 1979 | 221589 |
| cross-neutralization of infectious mononucleosis and burkitt lymphoma strains of epstein-barr virus with hyperimmune rabbit antisera. | 1979 | 221591 | |
| tumour promoter tpa enhances transformation of human leukocytes by epstein-barr virus. | 1979 | 221841 | |
| practical approach to diagnosis of infectious mononucleosis. | 1979 | 221896 | |
| expression of differentiated functions in hybrid cells. | 1979 | 223931 | |
| detection of a nuclear antigen in herpesvirus ateles-carrying marmoset lines by the acid-fixed nuclear binding technique. | in vitro binding of a herpesvirus ateles (hva)-associated soluble antigen to amphibian erythrocyte nuclei was demonstrated by the acid-fixed nuclear binding technique in combination with anticomplement immunofluorescence. incubation of concentrated salt-extracted soluble antigens derived from hva-carrying marmoset lines with methanol/acetic acid-fixed erythrocytes of frogs and salamanders resulted in a brilliant nuclear fluorescence after exposure to a live virus-boostered, anti-hvs-positive squ ... | 1979 | 221913 |
| the epstein-barr virus. | 1979 | 221971 | |
| alterations in cell characteristics in relation to malignant transformation. | 1979 | 222016 | |
| persistence, reactivation, and cell transformation by human herpeviruses: herpes simplex 1, 2 (hsv-1, hsv-2), cytomegalovirus (cmv), varicella-zoster (vzv), epstein-barr virus (ebv). | 1979 | 222414 | |
| long-term t-cell-mediated immunity to epstein-barr virus in man. iii. activation of cytotoxic t cells in virus-infected leukocyte cultures. | experiments have been conducted to determine the role played by immune t cells in the regression of eb-virus-induced transformation which is exclusively seen in leukocyte cultures from sero-positive donors. kinetic studies suggest that, in virus-infected cultures from such donors, a population of t cells proliferates within the first 2 weeks apparently in response to the appearance of virus-infected b cells. this proliferation continues to some extent during the period of regression. nonspecific ... | 1979 | 222691 |
| pleocytosis and immunoglobulin changes in cerebrospinal fluid and herpesvirus serology in patients with guillain-barré syndrome. | in a follow-up study of 24 patients with guillain-barré syndrome, 55% developed a cerebrospinal fluid (csf) mononuclear pleocytosis, which persisted for 4 months or more. raised index values of csf-immunoglobulin g (igg), csf-iga, and csf-igm, indicating synthesis of the immunoglobulin in question in the central nervous system, were found in 63, 35, and 25%, respectively. agarose gel eletrophoresis revealed oligoclonal immunoglobulin in csf in 21% and in both csf and serum in another 21% of the ... | 1979 | 222797 |
| simultaneous radioimmunoassay for specific antibodies to members of the human herpesvirus group. | a method of described for the simultaneous radioimmunoassay (ria) for antibody to members of the human herpesvirus group. the ria is compared with some of the conventional serologic techniques used to quantitate antibody to these viruses (epstein-barr virus, cytomegalovirus, herpesvirus type 1 and varicella-zoster virus). color-coded beads, each coated with the antigens of a different herpesvirus, were similtaneously placed in a well which contained a human serum to be assayed for antibody to ea ... | 1979 | 222846 |
| lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution. | human b cell lymphoma and murine t cell leukemia can be initiated by several agents. the present paper formulates some thoughts on the role of cytogenetic changes in the subsequent neoplastic process. initiation creates long-lived preneoplastic cells. in some respects, they are comparable to in vitro-transformed ("immortalized") cell lines that maintain a diploid karyotype and are not tumorigenic in vivo. the development of a tumorigenic ("autonomous") clone is dependent on additional changes at ... | 1979 | 221925 |
| the ebv-carrying, beta2m/hla deficient burkitt lymphoma line daudi is sensitive to ebv-specific killer t-cells of mononucleosis patients. | the beta2-microglobulin/hla deficient burkitt lymphoma line daudi was tested for sensitivity to ebv-specific cytotoxicity mediated by natural killer (nk)-depleted t-cells from acute mononucleosis patients. while the daudi line was not as sensitive as the reference ebv-genome-positive target line, it was clearly sensitive in the majority of cases. this would speak against a major role of syngeneic restriction in this system. | 1979 | 222436 |
| induction of plaque-forming cells in human blood lymphocytes cultured in the presence of antigen and epstein-barr virus: a study with normal donors and infectious mononucleosis patients. | normal human peripheral blood lymphocytes, stimulated in vitro with srbc in the presence of epstein-barr virus (ebv), gave rise to plaque-forming cells (pfc) specific for the antigen. pfc levels were very low before day 4 and increased thereafter, reaching a maximum around day 8. however, the kinetics of the response varied considerably from donor to donor and from experiment to experiment. in some instances a second peak of pfc was obtained beyond day 10. large differences in the magnitude of t ... | 1979 | 222519 |
| [eb virus and lymphocytes]. | 1979 | 222920 | |
| [herpesviruses in man]. | the importance and the extent of the inter-actions between herpes viruses and man is beginning to be understood. as more is learned about the natural histories of these viruses, it is becoming apparent that they have in common: horizontal spread during childhood, often with subclinical infection. latency in the host for many years, probably for life. potential for reactivation at a later time. host immune response maintained for life. potential for oncogeneiss. a more thorough knowledge of the b ... | 1979 | 222711 |
| infectious mononucleosis and encephalitis: recovery of eb virus from spinal fluid. | 1979 | 224373 | |
| [the role of herpes and papilloma viruses in human tumors]. | 1979 | 223047 | |
| mitogenic stimulation of leukemia cells by epstein-barr virus. | 1979 | 223056 | |
| a live human b-cell activator operating in isolation of other cellular influences. | using a reversed haemolytic plaque assay, we demonstrate that live but not inactivated epstein-barr (eb) virus can induce human blood lymphocytes to polyclonal ig (igm and igg) secretion in vitro. unlike pokeweed mitogen this b-cell-activating effect takes place in relative absence of t cells. eb virus thus promises to be a tool for study of b cell function isolated from other cellular influences, although its mechanism of activation appears to be different from that of previously known b cell a ... | 1979 | 223232 |
| recovery of epstein-barr virus from nonproducer neonatal human lymphoid cell transformants. | 1979 | 223286 | |
| long regions of single-stranded dna in human cells. | 1979 | 223063 | |
| the establishment of the suspension epstein-barr virus producing cell lines from patients with tumoral diseases. | isolation of the epstein-barr virus (ebv) in suspension lymphoblastoid cell lines from human patients with tumor diseases, mainly malignant lymphoma, has been described. it has been shown that the ebv was isolated from human patients with myeloid type of leukemia in 75% of cases. a similar virus was also isolated from patients with hodgkin's disease and leukemoid reaction of the myeloid type for lung cancer. morphological, cytochemical, immunological, and cytogenetic characteristics of the cell ... | 1979 | 223867 |
| [studies on epstein barr virus (ebv)-related antigens: biochemical characterization and purification of ebv-determined nuclear antigen (ebna) (author's transl)]. | 1979 | 223952 | |
| triplex gene dosage effect of tpi and g3pd in a human lymphoblastoid cell line with partial trisomy 12p13 and 18p. | the ebv-induced lymphoblastoid line established from a patient carrying a duplication of the distal part of chromosome 12 short arm (12p13) retained the original partial trisomy and displayed the same triplex gene dosage effect for tpi and g3pd as found in the patient's rbc and wbc. | 1979 | 223966 |
| simultaneous presence of ebna-positive and colony-forming cells in peripheral blood of patients with infectious mononucleosis. | ebna-positive lymphoblast cells were detected in 0.1 to 0.9% of the t-cell-depleted lymphocytes obtained from peripheral blood samples of five patients with infectious mononucleosis (im). the same blood specimens from four of the five patients contained cells that formed ebna-positive colonies in soft agar containing ebv antibodies. the ratio of the colony formers to ebna-positive cells was higher in blood samples taken early in the disease than in those obtained in later stages of the disease. ... | 1979 | 223990 |
| relationship between the epstein-barr virus genome and nasopharyngeal carcinoma in caucasian patients. | in order to explore whether undifferentiated nasopharyngeal carcinoma (npc) shows a regular association with epstein-barr virus (ebv), regardless of the geographical and ethnic origin of the patient, a correlated histopathological and nucleic acid hybridization study was performed on biopsies from caucasian patients with nasopharyngeal carcinomas and from various controls. among 12 undifferentiated npcs, 11 were positive for ebv-dna, with multiple copies of the viral genome per cell. serological ... | 1979 | 223991 |
| light and electron microscopic investigations of nasopharyngeal carcinomas with regard to the viral etiology of these tumors. | five carcinomata of the nasopharynx (four lymphoepithelial carcinomata of the regaud type and one squamous cell carcinoma) were examined light and electron microscopically. in addition to the familiar histological and cytological features of these tumors, and because of an increased antibody titer against epstein-barr virus in all five patients, all those cytoplasmic and nuclear inclusions were examined which could be interpreted as indicative of a virus contact. the following structures were fo ... | 1979 | 224065 |
| theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: iv. the viruses. | speculations are developed for a mechanism by which oncogenic viruses can induce alterations in cells allowing them to express embryonic genes. it is suggested that if viral deoxyribonucleic acid, directly or via ribonucleic acid directed deoxyribonucleic acid polymerase activity becomes inserted at particular euchromatin - heterochromatin junctions of quasidifferentiated stem-like cells, then deheterochromatization may result, causing in turn derepression of genes for acidic protein phosphokina ... | 1979 | 223021 |
| viral exposure and abnormal liver function in haemophilia. | several studies have recently documented the presence of persistently abnormal liver function tests in asymptomatic haemophiliacs. while the aetiology is unknown it is possible that repeated exposure to agents transmitted in blood products may be important. this study has attempted to determine the prevalence of viral exposure and its relationship to liver function in this multitransfused group of individuals. the prevalence of viral antibodies with the exception of antibody to hepatitis b surfa ... | 1979 | 221550 |
| [establishment of leukaemia cell lines and their significance for clinical and experimental oncology (author's transl)]. | permanent in vitro growing leukemic cell lines have been established from all types of immunologically classified childhood leukemias. essential characteristics of primary blasts and cultured cells are identical. in contrast to lymphoblastoid, non-leukemic cell lines, the epstein-barr-virus specific nuclear angiten (ebna) is not detected. up to now 8 non-b-non-t cell lines (6 of them were derived from children with acute lymphoblastic leukemia, 2 from patients with chronic myeloid leukemia), 8 t ... | 1979 | 221724 |
| tumor initiators and promoters in the induction of epstein-barr virus. | the effect of various tumor initiators and promoters on induction of persisting epstein-barr virus (ebv) in different lines of lymphoblastoid cells was analyzed. neither five polycyclic aromatic hydrocarbons, amongst them potent tumor initiators (e.g., 7,12-dimethylbenz[a]anthracene), nor the potent (ultimate) liver carcinogen n-acetoxy-n-2-acetylamino-fluorene induced ebv. a series of compounds, representing three classes of tumor-promoting diterpene esters (e.g., 12-o-tetradecanoylphorbol-13-a ... | 1979 | 218219 |
| cytomegalovirus granulomatous hepatitis. | three patients with granulomatous hepatitis due to cytomegalovirus are described. they are compared to the three previously described patients with this disease, and their clinical and serologic characteristics are discussed. similarities and differences between infectious mononucleosis (epstein-barr virus) and cytomegalovirus infections are adduced. that cytomegalovirus may be a cause of granulomatous hepatitis in the adult is stressed. | 1979 | 218449 |
| simultaneous infection with multiple herpesviruses. | 1979 | 218450 | |
| epstein-barr virus-specific rna. iii. mapping of dna encoding viral rna in restringent infection. | namalwa and raji cells, originally obtained from a burkitt tumor biopsy, grow as continuous cell lines in vitro and contain the epstein-barr virus (ebv)-related nuclear antigen ebna (b. m. reedman and g. klein, int. j. cancer 11:499-520, 1973) and rna homologous to at least 17 and 30% of the ebv genome, respectively (s. d. hayward and e. kieff, j. virol. 18:518-525, 1976; t. orellana and e. kieff, j. virol. 22:321-330, 1977). the polyribosomal and polyadenylated [poly(a)+] rna fractions of namal ... | 1979 | 219221 |