Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| are all 5-ht3 receptor antagonists the same? | a number of 5-ht3 receptor antagonists are currently in clinical development as antiemetics. in this paper we focus on two of these antagonists, granisetron and ondansetron, and compare their antimetic activity against cisplatin (10 mg/kg i.v.)- or whole body x-irradiation (200 rads)-induced emesis in the conscious ferret. the results presented here have been discussed in the light of the recently published literature. our data suggest that in comparison to ondansetron, granisetron is a more pot ... | 1992 | 1320915 |
| hematological and plasma chemical characteristics in beech marten (martes foina). | 1. the normal values of hematological and clinical-chemical variables in plasma of 21 males and 27 females of beech marten (martes foina) have been illustrated and compared to corresponding normal values in mink (mustela vison) and ferret (mustela putorius). 2. the number of erythrocytes, the hematocrit value, and the hemoglobin concentration were higher in male than in female beech marten. 3. divergences according to age in the investigated variables have been found. 4. the erythrocytes in beec ... | 1992 | 1355036 |
| trophic influences of excitatory and inhibitory synapses on neurones in the auditory brain stem. | the effects of a reduction during development of excitatory and inhibitory synaptic input on cns neurones were studied in the lateral superior olivary nucleus (lso) of the ferret following neonatal, unilateral cochlear removal. lso neurones normally receive excitatory input from the ipsilateral ear and inhibitory input from the contralateral ear. after cochlear removal, the ipsilateral lso was smaller and contained fewer neurones than either the contralateral or the normal lso. no difference was ... | 1992 | 1515583 |
| effects of endothelin on intracellular ca2+ and contractility in single ventricular myocytes from the ferret and human. | we investigated the role of endothelin-1 on peak intracellular ca2+ ([ca2+]i) and peak shortening of ventricular myocytes (loaded with indo-1/am) from failing human hearts. 10 nm of et-1 significantly increased the cell peak shortening (84 +/- 29%, p less than 0.05) without significantly increasing the peak [ca2+]i (15 +/- 7%, p greater than 0.05). further studies on ferret cardiac myocytes indicated that in addition to producing dose-dependent (0.1-10 nm) significant increases in peak shortenin ... | 1992 | 1516644 |
| helicobacter mustelae isolation from feces of ferrets: evidence to support fecal-oral transmission of a gastric helicobacter. | helicobacter mustelae has been isolated from stomachs of ferrets with chronic gastritis and ulcers. when h. mustelae is inoculated orally into h. mustelae-negative ferrets, the animals become colonized and develop gastritis, a significant immune response, and a transient hypochlorhydria. all of these features mimic helicobacter pylori-induced gastric disease in humans. because the epidemiology of h. pylori infection is poorly understood and its route of transmission is unknown, the feces of wean ... | 1992 | 1370432 |
| cytoarchitectonic heterogeneities in the thalamic reticular nucleus of cats and ferrets. | the thalamic reticular nucleus has been classically defined as a group of cells surrounding most of the rostral and lateral surfaces of the dorsal thalamus, lateral to the fibres of the external medullary lamina and medial to those of the internal capsule. with the use of nissl staining and antibodies to gamma-aminobutyric acid (gaba), somatostatin, and parvalbumin, this study describes the cytoarchitecture of the thalamic reticular nucleus of cats and ferrets. in cats, three subdivisions of the ... | 1992 | 1381730 |
| pulmonary venous pressure increases during alveolar hypoxia in isolated lungs of newborn pigs. | the purpose of this study was to determine whether pulmonary venous pressure increases during alveolar hypoxia in lungs of newborn pigs. we isolated and perfused with blood the lungs from seven newborn pigs, 6-7 days old. we maintained blood flow constant at 50 ml.min-1.kg-1 and continuously monitored pulmonary arterial and left atrial pressures. using the micropuncture technique, we measured pressures in 10 to 60-microns-diam venules during inflation with normoxic (21% o2-69-74% n2-5-10% co2) a ... | 1992 | 1399980 |
| induced periapical lesions in ferret canines: histologic and radiographic evaluation. | ferrets have been utilized in endodontic research to study periapical responses. however, various aspects of induction and healing of periapical pathosis in ferrets are unclear. this study evaluated the radiographic and histopathologic features of induced periapical lesions. periapical pathosis was consistently produced in 8 canines of 2 ferrets by extirpating the pulp, leaving the cavities open for a week, then sealing for 12 weeks. the resulting lesions were evaluated radiographically every tw ... | 1992 | 1521506 |
| membrane and synaptic properties of developing lateral geniculate nucleus neurons during retinogeniculate axon segregation. | during the first postnatal month in the ferret (mustela putorius furo), the projections from the retina to the lateral geniculate nucleus (lgn) become segregated into eye-specific layers and on and off sublayers, a process that is thought to depend in part on neuronal activity. remarkably, virtually nothing is known about the physiological features of lgn neurons during this period. we have recorded intracellularly from 46 a-layer neurons in slices of the ferret lgn between the ages of postnatal ... | 1992 | 1409711 |
| novel 5-ht3 antagonists. isoquinolinones and 3-aryl-2-pyridones. | synthesis and pharmacological evaluation of a series of 1,2-dihydro-1-[(5-methyl-1-imidazol-4-yl)methyl]-2-oxopyridine 5-ht3 antagonists are described. the key pharmacophoric elements were defined as a basic nitrogen, a linking group capable of hydrogen bonding interactions, and an aromatic moiety. 1,2-dihydro-2-oxopyridine moiety could be a good linking group because of its nicely planar structure. the steric limitations of the aromatic moiety were investigated by x-ray analysis and computer an ... | 1992 | 1527780 |
| 'reverse use-dependent' effects of 4-aminopyridine on the transient outward potassium current in ferret right ventricular myocytes. | 1992 | 1529768 | |
| mr lymphography with iron oxide compound ami-227: studies in ferrets with filariasis. | the purpose of this study was to assess the mr lymphographic potential of ami-227 to reduce the signal intensity of hyperplastic inflammatory lymph nodes by using ferrets with filariasis as the animal model. both interstitial and iv modes of administration were studied. | 1992 | 1529857 |
| dat-582, a novel serotonin3 receptor antagonist, is a potent and long-lasting antiemetic agent in the ferret and dog. | the antiemetic effects of a novel serotonin3 receptor antagonist, dat-582 [(6r)-(-)-n-[1-methyl-4-(3-methylbenzyl)hexahydro-1h-1,4- diazepin-6-yl]-1h-indazole-3-carboxamide dihydrochloride] were compared with those of the existing serotonin3 receptor antagonists, ondansetron and granisetron, in experimental animals. in ferrets, dat-582 (0.003-0.1 mg/kg i.v. twice) dose-relatedly prolonged the latency to the first emetic episode and decreased the number of emetic episodes induced by cisplatin (10 ... | 1992 | 1532032 |
| ca(2+)-independent isoforms of protein kinase c differentially translocate in smooth muscle. | it is generally assumed that smooth muscle contraction is dependent on changes in intracellular ca2+ concentration ([ca2+]i); however, we have previously reported that alpha-agonist-induced contraction of aorta smooth muscle cells can occur in the absence of changes in [ca2+]i [collins, e. m., m. p. walsh, and k. g. morgan. am. j. physiol. 262 (heart circ. physiol. 31): h754-h762, 1992]. the mechanism of this [ca2+]i-independent contraction is controversial. we have now identified the ca(2+)-ind ... | 1992 | 1415520 |
| biocompatibility of retrograde filling materials in the ferret canine. amalgam and irm. | periapical tissue response to retrograde fillings of amalgam and irm were compared in the mandibular canine of the adult male ferret. teeth were cleaned and shaped with a standard technique and obturated with gutta-percha. the root apex was then exposed and retrofillings were placed. the animals were grouped according to observation periods of 5, 10, and 15 weeks. at the proper time the animals were killed and the lower canine tooth along with the surrounding bone was removed. the tissue blocks ... | 1992 | 1437046 |
| myocardial energetics during ventricular fibrillation investigated by magnetization transfer nuclear magnetic resonance spectroscopy. | ventricular fibrillation (vf) is known to produce alterations in myocardial energetics, but the mechanism of these changes remains unclear. to investigate energy metabolism during vf, phosphorus nuclear magnetic resonance spectroscopy and magnetization transfer were applied to isolated perfused ferret hearts. vf was induced either by perfusion with digitalis (strophanthidin, 30 microm) or by high-frequency electrical stimulation. we measured the flux in two critical reactions: from inorganic pho ... | 1992 | 1394873 |
| proteoglycan secretory components of surface epithelial cells in postnatal ferret trachea. | 1992 | 1541184 | |
| effects of endothelin-1 on tracheal submucosal gland secretion and epithelial function in the ferret. | 1992 | 1541210 | |
| pituitary adenylate cyclase activating peptide: a novel vasoactive intestinal peptide-like neuropeptide in the gut. | pituitary adenylate cyclase activating peptide (pacap) is a vasoactive intestinal peptide (vip)-like hypothalamic peptide occurring in two forms, pacap-27 and the c-terminally extended pacap-38. the predicted rat and human pacap sequence is identical to the isolated ovine one. in the present study, the occurrence and distribution of pacap-like peptides were examined in the gut of several species by immunocytochemistry and immunochemistry using an antibody raised against pacap-27. pacap-like immu ... | 1992 | 1542417 |
| the attenuation phenotype conferred by the m gene of the influenza a/ann arbor/6/60 cold-adapted virus (h2n2) on the a/korea/82 (h3n2) reassortant virus results from a gene constellation effect. | a single gene reassortant (sgr) virus that derived its m gene from the attenuated influenza a/ann arbor/6/60 cold-adapted (ca) donor virus and the remaining genes from the a/korea/82 (h3n2) wild type (wt) virus (designated a/korea/82 ca m-sgr) was previously shown to be attenuated in mice, hamsters, ferrets, and humans. the attenuation (att) phenotype of this sgr virus could result directly from an altered function of the mutant m gene product of the a/ann arbor/6/60 ca virus, which differs from ... | 1992 | 1413993 |
| mouse model for pneumocystis carinii pneumonia that uses natural transmission to initiate infection. | animal models for pneumocystis carinii, for the most part, have been limited to immunosuppressed rats and ferrets, while a dependable mouse model has been more difficult to develop. a p. carinii mouse model has now been established with several strains of mice, including c3heb/fej, c3hen, balb/c, dba/2n, and balb/c nu/nu (athymic). in lieu of using invasive methods for initiating p. carinii infections, mice harboring p. carinii transmitted the disease to mice without latent infection via short-t ... | 1992 | 1548065 |
| development of high-affinity 5-ht3 receptor antagonists. 2. two novel tricyclic benzamides. | two new classes of potent 5-ht3 agents have been developed and examined as inhibitors of cytotoxic drug induced emesis in the ferret and dog. the absolute configuration of the most active molecules 10 and 18 have been determined by x-ray crystallography. these two compounds are more potent than known 5-ht3 receptor antagonists both in vivo and in vitro in blocking 5-ht3 receptor activation and preventing chemotherapeutic induced emesis. compared with 5-ht3 antagonists, such as gr 38032f, zacopri ... | 1992 | 1548679 |
| [effects of magnesium on early post-depolarization and trigger activity induced by cesium on purkinje fibers in ferrets]. | the effects of magnesium (mg) on afterdepolarisations and cesium-induced activity were studied in 15 preparations of ferret purkinje fibres. when the perfusion medium was enriched with mg to concentrations of 5 mm, the duration of the action potentials stopped increasing and the diastolic membrane potential was stabilised despite persistent exposure to cesium. a suppressor effect of mg on the high and low voltage early afterdepolarisations was observed which was significant at 2.2 mm (p less tha ... | 1992 | 1550438 |
| force production in voltage-clamped human atrial muscle. | human atrial muscle preparations obtained during open heart surgery were mounted in a sucrose gap. force and membrane currents were recorded during voltage clamp. after a 20-s rest, 10 clamps from a holding potential of -40 to 0 mv at 1.0 hz were given. this was followed by a test clamp (called 1) of a varied duration and amplitude and two more test clamps (called 2 and 3) as during the priming period. peak force of contraction 1 (f1) was independent of clamp duration from 2s to about 100 ms but ... | 1992 | 1442125 |
| an angiographic method for in vivo study of arteries of the circle of willis in small animals. | an x-ray imaging technique designed to allow sequential diameter measurements of the cerebral vessels in intact, anesthetized small animals under relatively physiological conditions is described. the ferret and the rabbit were chosen as potentially useful animal models for studying the cerebrovascular system because of the advantageous anatomic characteristics of these relatively small species. a commercially available and relatively inexpensive x-ray imaging system with a small focal spot provi ... | 1992 | 1443212 |
| the effects of intraluminal and extraluminal drug application on secretion and smooth muscle tone in the ferret liquid-filled trachea in vitro. | with the ferret liquid-filled trachea in vitro, intraluminal methacholine (mch), phenylephrine (pe) and histamine (hist) increased smooth muscle tone and salbutamol (salb) decreased tone. lysozyme output was increased by intraluminal mch and pe. albumin transport into the lumen was not altered by intraluminal hist, salb or pe. the concentration-response curves for smooth muscle contraction and for lysozyme output to extraluminal mch lay to the left of those for intraluminal mch. indomethacin shi ... | 1992 | 1446138 |
| malignant lymphoma in ferrets: clinical and pathological findings in 19 cases. | the clinical and pathological findings in 19 ferrets (mustela putorius furo) with malignant lymphoma are reviewed. peripubescent ferrets had rapidly progressive stage iv high grade immunoblastic or small non-cleaved cell lymphoma. adult ferrets had stage ii or iv low grade diffuse small lymphocytic (dsl) lymphoma, stage iv high grade small non-cleaved cell lymphoma, or stage iv high grade immunoblastic polymorphous (ibp) lymphoma. three ferrets had concurrent ibp and dsl lymphoma involving diffe ... | 1992 | 1556256 |
| effect of immunisation against vasoactive intestinal polypeptide on gastric corpus tone and motility in the ferret. | the role of vasoactive intestinal polypeptide in the control of gastric corpus tone and motility was investigated using auto-antibodies to neutralise endogenous vasoactive intestinal polypeptide. six ferrets were immunised with vasoactive intestinal polypeptide thyroglobulin conjugate in freund's complete adjuvant which resulted in a significant increase in plasma vasoactive intestinal polypeptide binding activity compared with unimmunised control animals. in acute experiments the level of spont ... | 1992 | 1452070 |
| neuropharmacology of emesis in relation to clinical response. | 5-ht3 receptor antagonists such as ondansetron, granisetron, ics205-930 and zacopride are highly effective in the ferret, cat or dog to prevent emesis caused by cisplatin and other chemotherapeutic agents, and radiation treatment. the anti-emetic effects may be mediated centrally in the area postrema and associated structures of the emetic reflex such as the nucleus tractus solitarius, which have a very high density of 5-ht3 receptors. additional sites of action may be found on the 5-ht3 recepto ... | 1992 | 1467196 |
| metabolic changes during ischaemia and their role in contractile failure in isolated ferret hearts. | 1. the effects of global ischaemia on phosphorus metabolites, intracellular ph (phi) and developed pressure were measured in isolated whole ferret hearts using 31p nuclear magnetic resonance (nmr) spectroscopy. 2. brief (10 min) periods of global ischaemia reduced left ventricular developed pressure (lvdp) to undetectable levels. this fall in lvdp was accompanied by a fall in the intracellular concentration of phosphocreatine (pcr) and increases in the concentrations of inorganic phosphate (pi) ... | 1992 | 1474498 |
| concurrent mammary gland hyperplasia and adrenocortical carcinoma in a domestic ferret. | mammary gland hyperplasia associated with adrenocortical carcinoma in a domestic ferret had a histologic appearance similar to that observed in cats. it is important to consider this hyperplastic condition in the differential diagnosis of mammary gland enlargement in the ferret. | 1992 | 1483915 |
| mechanisms by which cancer chemotherapeutic drugs induce emesis. | because the area postrema seems essential for chemotherapy-induced vomiting, both circulating and/or neurally mediated stimuli in this area could trigger the emetic response. in our laboratories results of cross-circulation and direct intracerebroventricular infusion experiments in dogs do not support a role for circulating substances. the large increases in serum vasopressin induced by cisplatin were not blocked by inhibitors of the angiotensin-converting enzyme. in the ferret inhibition of ser ... | 1992 | 1485177 |
| position of growth cones within the retinal nerve fibre layer of fetal ferrets. | optic axons are added to the retinal nerve fibre layer of fish along its vitreal border in a chronotopic manner. likewise, the optic tract of all vertebrate species acquires axons preferentially along the superficial surface of the pathway. we have examined the developing retina of fetal ferrets (mustela putorius furo) aged between embryonic day 27 (e27) and e34 to see whether a similar segregation of growth cones is apparent within the mammalian retinal nerve fibre layer. the distributions of g ... | 1992 | 1401254 |
| influenza vaccine strain selection: equivalence of two antigenically distinct haemagglutinin variants of 1989 h3n2 influenza a virus in protection of mice. | precise antigenic analysis with haemagglutinin-inhibition (hi) tests of 1989 h3n2 influenza a viruses with polyclonal ferret, rabbit and mouse antisera has shown, first, significant differences among 1989 wild-type isolates, second, antigenic differences between two high-yield vaccine candidate reassortant viruses, third, significant antigenic differences of one reassortant (x-105) from the wild-type virus (a/guangdong a/39) from which it was derived, and fourth, dependence of antigenic characte ... | 1992 | 1502837 |
| age-related differences in vascular effects of pentoxifylline in isolated perfused ferret lungs. | we have determined the magnitude and sites of action of pentoxifylline (ptx), a methylxanthine derivative, in the adult and 3- to 4-week old ferret pulmonary circulation. lungs of 8 ferrets, four 3- to 4-week-old and 4 adult, were isolated and perfused with blood. during perfusion, blood flow was kept constant, as were airway and left atrial pressures (6 and 8 cm h2o respectively, zone 3 conditions). in all lungs, pulmonary artery pressure was measured continuously and the circulation was partit ... | 1992 | 1483354 |
| interactions of the exchange inhibitory peptide with na-ca exchange in bovine cardiac sarcolemmal vesicles and ferret red cells. | the na-ca exchange inhibitory peptide (xip), which corresponds to residues 251-270 of the na-ca exchange protein, specifically inhibits exchange activity (li, z., nicoll, d. a, collins, a., hilgemann, d. w., filoteo, a. g., penniston, j. t., weiss, j. n., tomich, j. m., and philipson, k. d. (1991) j. biol. chem. 266, 1014-1020). we have found that xip decreased na+i-dependent ca2+ uptake to 46 and 20% of control in mixed and inside-out bovine sarcolemmal (sl) vesicles, respectively, and to 22% o ... | 1992 | 1517221 |
| jaw-muscle activity in ferrets, mustela putorius furo. | electromyographical (emg) activity was recorded bilaterally from the masseter and temporalis muscles of alert ferrets (mustela putorius furo) during mastication and crushing. electromyographic activity was also recorded during biting while a bite-force transducer placed between the carnassial teeth registered forces ranging from 1.5 to 48.8 n. linear regression analysis demonstrates that temporalis and masseter emg activity are linearly related to bite force. electromyographic activity from the ... | 1992 | 1518073 |
| separate effects of ischemia and reperfusion on vascular permeability in ventilated ferret lungs. | in systemic organs, ischemia-reperfusion injury is thought to occur during reperfusion, when oxygen is reintroduced to hypoxic ischemic tissue. in contrast, the ventilated lung may be more susceptible to injury during ischemia, before reperfusion, because oxygen tension will be high during ischemia and decrease with reperfusion. to evaluate this possibility, we compared the effects of hyperoxic ischemia alone and hyperoxic ischemia with normoxic reperfusion on vascular permeability in isolated f ... | 1992 | 1490978 |
| nicotine increases ciliary beat frequency by a direct effect on respiratory cilia. | we studied the direct effects of nicotine on the ciliary beat frequency (cbf) undisturbed by interference from mucus secretion by using epithelial strips from ferret tracheae which contain no goblet cells and, because the glands were left behind in the submucosa, no gland tissue either. strips were studied in a chamber perfused with medium m-199 at 37 degrees c at a perfusion rate of 1.6 ml min-1 using a perfusion pump (braun, melsungen). cbf was determined photometrically, the signal being subj ... | 1992 | 1521039 |
| paf-induced muscarinic cholinoceptor hyperresponsiveness of ferret tracheal smooth muscle and gland secretion in vitro. | 1. the effects of exposure of the ferret trachea in vitro to platelet activating factor (paf) were examined on methacholine-induced smooth muscle contraction, mucus volume and lysozyme outputs, and albumin transport across the tracheal epithelium. 2. methacholine (0.1-30 microm) produced concentration-dependent increases in tracheal smooth muscle tone and mucus volume, lysozyme and albumin outputs from the trachea. 3. the concentration-response curves for methacholine-induced smooth muscle contr ... | 1992 | 1596686 |
| lymphatic imaging in experimental filariasis using magnetic resonance. | to evaluate acquired lymphatic abnormalities caused by filariasis, the authors examined the peripheral lymphatic system in normal ferrets and those chronically infected with brugia malayi using magnetic resonance imaging (mri). the findings were compared with previously obtained lymphangioscintigraphic (las) images in ferrets both with and without experimental filariasis. | 1992 | 1601619 |
| intracellular calcium and ventricular function. effects of nisoldipine on global ischemia in the isovolumic, coronary-perfused heart. | ischemia-induced ventricular dysfunction has been shown to be associated with increased diastolic and systolic intracellular concentrations of free, ionized calcium ([ca2+]i). the present study was designed to determine the effects of the ca2+ antagonist nisoldipine on the relationship between [ca2+]i and left ventricular contraction and relaxation during ischemia and reperfusion on a beat-to-beat basis. nine isovolumic coronary-perfused ferret hearts were made globally ischemic for 3 min and re ... | 1992 | 1602012 |
| bile salt stimulated lipase: comparative studies in ferret milk and lactating mammary gland. | bile salt stimulated lipase (bssl) activity is 10-20 times higher in ferret milk than in human milk. we have used the ferret to study bssl activity in lactating mammary gland and in mammary cells isolated by hyaluronidase-collagenase treatment followed by ficoll gradient centrifugation. furthermore, we have compared the characteristics of bssl in the tissue preparations (homogenate or cells) to bssl of ferret milk and to bssl purified from ferret and human milk. the characteristics of bssl in fe ... | 1992 | 1491611 |
| rapid development of the auditory brainstem response threshold in individual ferrets. | the development of the ferret auditory system was examined using the auditory brainstem response (abr). longitudinal recordings were obtained under short-acting anaesthesia from individual animals at 4-h or 24-h intervals. particular attention was focused on the period from postnatal day (p) 26 to p32 when the ferret auditory system becomes functional. abr thresholds to click stimuli presented in a free-field were found to decline precipitously within a 4-h period during the first 24 h following ... | 1992 | 1606688 |
| activation of two types of fibres in ferret, mustela putorius furo, cremaster muscle. | some contractile, histochemical, morphological and electrophysiological properties of ferret, mustela putorius furo, cremaster muscle have been estimated. histochemical fibre typing revealed the presence of two types of fibres (type i 66.2%, type ii 33.8%). morphometry performed on atpase-stained transverse sections showed that type i was composed of a large amount (40%) of small (less than 1400 microns2) cells. in mammalian ringer two groups of fibres could be recognized on the basis of the val ... | 1992 | 1534331 |
| endocardial endothelium modulates myofilament ca2+ responsiveness in aequorin-loaded ferret myocardium. | the influence of selective removal of the endocardial endothelium (by a 1-second exposure to the detergent triton x-100, 0.5%) on myofilament ca2+ responsiveness and intracellular ca2+ transients was studied in ferret papillary muscles loaded with the ca(2+)-regulated bioluminescent indicator aequorin. the removal of endocardial endothelium produced three major effects: 1) a decrease in peak developed tension and an early onset in isometric relaxation without corresponding changes in the intrace ... | 1992 | 1551201 |
| effect of mebeverine hydrochloride on jejunal motility and epithelial transport in the anesthetized ferret. | previous in vitro and in vivo studies demonstrate that mebeverine, administered to isolated smooth muscle preparations or given intravenously, (i.v.), acts as an antispasmodic agent and may be useful in treating intestinal hypermotility. whether mebeverine affects intestinal mucosal transport is, however, unknown. the aim of the present study was to characterize the effect of mebeverine on both small intestinal motor activity and electrogenic epithelial transport in the urethane anesthetized fer ... | 1992 | 1612107 |
| endogenous arachidonic acid metabolism by calcium ionophore stimulated ferret lungs. effect of age, hypoxia. | we have studied the metabolism of endogenous arachidonic acid by isolated perfused lungs of ferrets when stimulated with calcium ionophore a23187 at two ages, neonatal (2- to 3-week-old) and adult (greater than 6 months). we have also determined the effect of hypoxia on lung metabolism of arachidonic acid in the two age groups. lungs were perfused with kreb's bicarbonate buffer in a recirculating system and eicosanoid production was stimulated by addition of a23187 (5 microm). eicosanoids produc ... | 1992 | 1538590 |
| role of transsarcolemmal ca2+ entry in the negative inotropic effect of nitrous oxide in isolated ferret myocardium. | the purpose of this study was to investigate the effects of nitrous oxide (n2o) on transsarcolemmal calcium influx in isolated ferret right ventricular myocardium. using a range of loading conditions, papillary muscles were equilibrated in 50% nitrogen (n2) or 50% n2o in oxygen in the presence and absence of ryanodine, a specific inhibitor of calcium release from the sarcoplasmic reticulum. after equilibration in 50% n2o or 50% n2 in oxygen, peak developed force, peak isotonic shortening, and ma ... | 1992 | 1554125 |
| comparative vaginal cytology of the estrous cycle of black-footed ferrets (mustela nigripes), siberian polecats (m. eversmanni), and domestic ferrets (m. putorius furo). | vaginal cytology and vulva size were used to characterize the reproductive cycle of female black-footed ferrets (mustela nigripes), siberian polecats (m. eversmanni), and domestic ferrets (m. putorius furo). emphasis was on black-footed ferrets because of the need to breed these critically endangered animals and on siberian polecats because of the close taxonomic relationship to black-footed ferrets. vaginal cytology of the 3 species of ferret is similar. proestrus was characterized by an increa ... | 1992 | 1554767 |
| subacute toxicity and maximum tolerable dose of sertaconazole in repeated administration studies. | 28-day oral and dermal subacute toxicity studies of 7-chloro-3-[1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl) ethoxy-methyl] benzo [b] thiophene (sertaconazole, fi-7045, cas 99592-32-2), were carried out. the oral studies included the evaluation of subacute toxicity in rat (dose levels of 50, 150 and 300 mg/kg) and maximum tolerable dose in repeated administration in ferrets (consecutive dose levels in accordance with a geometric progression of 50, 75, 112.5, 168 and 250 mg/kg), which were the ani ... | 1992 | 1627193 |
| chronic toxicity studies of sertaconazole after oral administration to rats and ferrets. | six-month chronic oral toxicity studies of 7-chloro-3-[1-(2, 4-dichlorophenyl)-2-(1h-imidazol-1-yl)ethoxy-methyl] benzo[b]thiophene (sertaconazole, fi-7045, cas 99592-32-2) were carried out in rats and ferrets. the dose levels used were 50, 150 and 300 mg/kg in rats and 50, 150 and 250 mg/kg in ferrets. there was no mortality associated with the drug in either of the two species. the results obtained show that the toxic effects may be summarized as a smaller body weight increase in rats at 150 a ... | 1992 | 1627194 |
| eosinophilic gastroenteritis with splendore-hoeppli material in the ferret (mustela putorius furo). | eosinophilic gastroenteritis, focal or diffuse with eosinophilic infiltrations of the stomach or intestine, has been described in human beings, cats, dogs, and horses. in this paper, we describe infiltration of the gastrointestinal tract with eosinophils accompanied by a circulating eosinophilia in six ferrets (mustela putorius furo). clinical signs included chronic weight loss, anorexia, and diarrhea. the small intestines from five ferrets had diffuse infiltrates of eosinophils. this resulted i ... | 1992 | 1557863 |
| pancreatic adenocarcinoma with metastasis in two ferrets. | exocrine pancreatic adenocarcinoma with carcinomatosis was diagnosed in 2 ferrets. clinical signs included abdominal distention and hind limb weakness. ultrasonography revealed moderate ascites in both ferrets, an irregular abdominal mass in 1 ferret, and multiple abdominal masses in the other ferret. the ferrets were euthanatized, and necropsy of 1 ferret revealed carcinomatosis without visceral metastasis. | 1992 | 1506255 |
| action potential duration and endocardial modulation of myocardial contraction in the ferret. | endocardial endothelium releases substances which modulate myocardial contraction. selective endocardial removal abbreviates contraction by removing a contraction prolonging substance "endocardin". the aim of the study was to investigate whether changes in action potential duration underlie these contractile effects. | 1992 | 1638571 |
| effect of ketamine hcl on norepinephrine disposition in isolated ferret ventricular myocardium. | the purpose of this study was to determine if ketamine altered the release or disposition of norepinephrine at adrenergic nerve terminals in isolated ferret myocardium. in superfused right ventricular strips, the effect of ketamine on norepinephrine release and uptake was determined. dihydroxyphenylglycol, the intraneuronally derived metabolite of norepinephrine, served as an index of neuronal uptake and was also measured in superfusate. pharmacological manipulation of selective aspects of adren ... | 1992 | 1560358 |
| parvovirus-associated syndrome (aleutian disease) in two ferrets. | there is a paucity of information regarding natural aleutian disease, caused by a parvovirus in ferrets. with the increasing popularity of ferrets as household pets and laboratory animals, and with the advent of a usda-approved rabies vaccine, the occurrence and the etiopathogenesis of naturally acquired diseases in ferrets needs to be documented. we present the clinical and laboratory findings associated with aleutian disease in 2 domestic ferrets, one with the chronic wasting form of the disea ... | 1992 | 1644626 |
| distemper vaccination in ferrets. | 1992 | 1546441 | |
| pulp response to bases and cavity depths. | in cavities of ferret canines, preparation depth and bases were compared as to their effect on odontoblasts and to rate of dentin formation. these were measured by injecting 3h-proline at 0, 20 and 40 days post-preparation. odontoblast activity was determined by label density in each band; inter-band distances indicated the amount of dentin formed. correlations were by pearson's coefficient. the following were determined: 1) cavity depth (remaining dentin thickness) was the major factor in odont ... | 1992 | 1524748 |
| haemagglutination profiles of helicobacter species that cause gastritis in man and animals. | thirty-five helicobacter pylori isolates, 21 h. mustelae isolates and four strains of h. felis were compared for their ability to agglutinate red blood cells (rbcs). isolates were examined in a slide haemagglutination assay with rbcs from 11 animal species, including rodents, carnivores and primates, as well as man. rbcs were agglutinated by 65-90% of h. mustelae isolates and 16-57% of h. pylori isolates. treatment of h. mustelae with pronase and heat inhibited haemagglutination (ha) whereas hea ... | 1992 | 1279175 |
| origin and fate of fetuin-containing neurons in the developing neocortex of the fetal sheep. | the development of the neocortex has previously been extensively studied in carnivores (cat and ferret), rodents (rat and mouse) and primates (monkey and human). in these species, it has been shown that the initial population of cells migrating from the ventricular zone forms the primordial plexiform layer. this is subsequently split into marginal zone and subplate zone by the insertion of later-migrating cells into the primordial plexiform layer, to form the cortical plate proper. many of the c ... | 1992 | 1280010 |
| nitric oxide synthase in ferret brain: localization and characterization. | 1. in the present study, we have investigated the distribution of nitric oxide synthase in the ferret brain. nitric oxide synthase was determined biochemically and immunochemically. 2. in the rat brain, the highest nitric oxide synthase activity has been detected in the cerebellum. however, in the ferret brain, the highest activity was found in the striatum and the lowest in the cerebellum and cerebral cortex. the enzymatic activity was localized predominantly in the cytosolic fractions, it was ... | 1992 | 1282076 |
| cyclic gmp inhibits the inotropic response to alpha 1-adrenoceptors in the papillary muscle of the ferret. | the physiological role of cyclic gmp in the heart remains controversial. in the present study we investigated the interaction between a number of agents known to increase the level of cyclic gmp in the myocardium and alpha 1-adrenergic stimulation in isolated preparations of cardiac papillary muscle in the ferret. inotropic responses to the cumulative addition of phenylephrine were measured in papillary muscles of the ferret in the absence and presence of 1 microm sodium nitroprusside, 1 microm ... | 1992 | 1282377 |
| two components of the pineal organ in the mink (mustela vison): their structural similarity to submammalian pineal complexes and calcification. | the pineal complex in the mink (mustela vison) consists of a larger ventral and a smaller dorsal pineal. both organs contain pinealocytes, neurons, glial cells, nerve fibers and synapses in an organization characteristic of nervous tissue. the cellular elements are arranged circularly around strait lumina. these lumina correspond to the photoreceptor spaces of submammalian pineals. a 9 + 0-type cilium marks the receptory pole of the pinealocytes which may form an inner-segment-like dendrite term ... | 1992 | 1295547 |
| [the fever reaction of the polecat mustela putorius x mustela putorius furo to a bacterial pyrogen: the hypo- and hyperthermic phases]. | it has been demonstrated that the ferret (mustela putorius x mustela putorius furo) responds to intramuscular injection of salmonella typhi lipopolysaccharide (30 ng/kg-100 micrograms/kg) by biphasic change in the body temperature (tb): the initial decrease in the latter is followed by hyperthermia. maximum rise in tb (1.6 +/- 0.1 degrees c) was observed after the injection of lipopolysaccharide in the highest dose. rabbit leucocytic pyrogen/interleukin-1 (1 ml from 3.5 x 10(7) peritoneal phagoc ... | 1992 | 1302417 |
| development of high-affinity 5-ht3 receptor antagonists. 1. initial structure-activity relationship of novel benzamides. | this report describes the development of novel benzamides which are orally active, highly potent, specific antagonists of 5-ht3 receptors. described in this first report are the structure-activity relationships that led to novel structures with improved potency and selectivity. from this series of compounds, (s)-28 was identified and selected for further evaluation as a 5-ht3 receptor antagonist. compared with 5-ht3 antagonists such as gr 38032f, brl 43694, and metoclopramide, (s)-28 was most ac ... | 1992 | 1312602 |
| luteinizing hormone-releasing hormone neurons which are r-etrogradely labeled after peripheral fluoro-gold administration in the male ferret. | this study identified luteinizing hormone-releasing hormone (lhrh)-producing neurons which have access to fenestrated capillaries in prepubertal male european ferrets. fluoro-gold was injected intraperitoneally to retrogradely label neurons with terminals outside the blood-brain barrier. lhrh neurons were identified by immunofluorescence using a secondary antibody tagged with tetramethylrhodamine isothiocyanate. cell bodies which demonstrated both tetramethylrhodamine isothiocyanate and fluoro-g ... | 1992 | 21554662 |
| comparison of the lesions of aleutian disease in mink and hypergammaglobulinemia in ferrets. | gross and microscopic lesions of aleutian disease (ad) in mink and hypergammaglobulinemia in ferrets were compared. both conditions were characterized by widespread proliferation of plasma cells, but proliferation was more prominent in mink infected with ad. arteritis did not occur in hypergammaglobulinemic ferrets. minimal or no glomerular alterations occurred in infected ferrets, but were severe in mink infected with ad. bile duct proliferation was more prominent in diseased mink. tissue alter ... | 1992 | 206172 |
| the impact of population growth on environment: the debate heats up. | a proposed framework, which was introduced at the 1989 meetings of the american association for the advancement of science, included political constraints as well as population growth as a proximate cause with potentially important impacts on the environment in paul and ann ehrlich's well-known pat equation. pat limitations are identified as the 1.2 billion people caught in the debt-poverty trap, less developed countries' balance of payments deficits, and "distortionary factors" that undermined ... | 1992 | 12290504 |
| cytological diagnosis of chordoma of the tail in a ferret. | 1992 | 12671792 | |
| beta-carotene, retinol and retinyl ester concentrations in serum and selected tissues of ferrets fed beta-carotene. | the concentrations of beta-carotene, retinol and retinyl esters in serum and selected tissues of ferrets fed diets supplemented with beta-carotene (80 micrograms/g wet diet) for 3 wk were determined. the initial concentration of serum beta-carotene was 0.011 +/- 0.006 mumol/l (mean +/- sem); at the end of the experimental period it was 5.75 +/- 1.60 mumol/l. no significant differences in serum retinol and total retinyl esters were observed between beta-carotene-fed and control ferrets that had b ... | 1992 | 1512640 |
| a nuclear magnetic resonance investigation of the upper airways in ferrets. ii. contrast-enhanced imaging to distinguish vascular from other nasal fluids. | proton magnetic resonance imaging (mri), used in conjunction with the intravascular contrast agent albumin-(gd-dtpa), provides a means to distinguish vascular fluids from other nasal fluids in the upper airways. ferrets were given an intravenous dose of albumin-(gd-dtpa) followed by an intranasal challenge with either histamine (hs) or methacholine (mc). an observed increase in image intensity indicates that hs and mc both cause an accumulation of fluids in the nasal turbinate region. the mri da ... | 1992 | 1435208 |
| a nuclear magnetic resonance investigation of the upper airways in ferrets. i. effects of histamine and methacholine. | alterations induced in the upper airways of ferrets by intranasal provocation with methacholine (mc) and histamine (hs) were monitored using proton magnetic resonance imaging (mri) and spin-spin relaxation rate (r2) measurements. both mc and hs cause a significant increase in the mri signal intensity and a decrease in r2 in the nasal turbinates. a dose-dependent response is observed for 20 to 315 nmol of hs, with a maximum increase in intensity of ca. 50% occurring above 80 nmol. a single unilat ... | 1992 | 1435207 |
| translaminar deficits in the retinae of albinos. | the central retina in albino mammals is poorly developed. there is a general reduction in ganglion cell density compared with the normal animal, and there are irregularities in the center to periphery gradient in ganglion cell density. it is not known whether, and if so to what extent, this abnormality is associated with deficits in other retinal layers. in this study the distribution of cells in the ganglion cell layer has been determined in horizontally sectioned eyes from pigmented and albino ... | 1992 | 1484126 |
| role of pulmonary blood flow in postpneumonectomy lung growth. | to study the influence of blood flow on postpneumonectomy lung growth, we banded the left caudal lobe pulmonary artery of eight ferrets in such a way that blood flow to the caudal lobe did not increase when the right lung was excised 1 wk later. the fraction of the cardiac output received by the right lung before pneumonectomy was therefore directed entirely to the left cranial lobe. three weeks after pneumonectomy the weight, volume, and protein and dna contents of the two lobes of the left lun ... | 1992 | 1490957 |
| transfusions in exotic species. | there has been a considerable increase in the popularity of exotic species as pets, particularly, birds and domestic ferrets. blood transfusions in birds and ferrets are discussed. there is a brief review of hematology, blood collection techniques, the selection and maintenance of donor animals, and the mechanics of transfusion. because of the marked differences between birds and mammals, attention is given to avian anatomy and physiology as it applies clinically to blood transfusions. | 1992 | 1472773 |
| responses of sagittally aligned purkinje cells during perturbed locomotion: relation of climbing fiber activation to simple spike modulation. | 1. the purpose of these experiments is to test the hypothesis that the synchronous activation of sagittally aligned purkinje cells by a physiologically relevant stimulus is associated with an increase in the simple spike responses of the same neurons. 2. this hypothesis was tested using a perturbed locomotion paradigm in decerebrate locomoting ferrets. the responses of 3-5 sagittally aligned purkinje cells were recorded simultaneously in response to the intermittent perturbation of the forelimb ... | 1992 | 1479447 |
| aleutian disease in ferrets. | 1992 | 1441131 | |
| visual projections routed to the auditory pathway in ferrets: receptive fields of visual neurons in primary auditory cortex. | how does cortex that normally processes inputs from one sensory modality respond when provided with input from a different modality? we have addressed such a question with an experimental preparation in which retinal input is routed to the auditory pathway in ferrets. following neonatal surgical manipulations, a specific population of retinal ganglion cells is induced to innervate the auditory thalamus and provides visual input to cells in auditory cortex (sur et al., 1988). we have now examined ... | 1992 | 1527604 |
| responses of sagittally aligned purkinje cells during perturbed locomotion: synchronous activation of climbing fiber inputs. | 1. these experiments were performed to test the hypothesis that climbing fiber inputs to sagittally aligned purkinje cells located in a single folium are activated synchronously in response to a perturbation of the step cycle that interrupts the trajectory of the ipsilateral forelimb. 2. the experiments were performed in acutely decerebrate ferrets capable of walking spontaneously on a moving treadmill. a multiple single-unit recording technique was employed utilizing a fixed array of five sagit ... | 1992 | 1527576 |
| emesis in ferrets following exposure to different types of radiation: a dose-response study. | ferrets were exposed to gamma rays (60co), fission neutrons, high-energy electrons (18.5 mev) or iron particles (56fe, 600 mev/amu) in order to establish the dose-response relationships for emesis following exposure to different types of radiation. the results showed that the mean effective doses (ed50s) for iron particles (35 cgy) and neutrons (40 cgy) were similar. high-energy electrons were the least effective radiation, with an ed50 of 138 cgy. gamma rays, with an ed50 of 95 cgy, showed an i ... | 1992 | 1510644 |
| pharmacology and preclinical antiemetic properties of ondansetron. | ondansetron (gr 38032) has potent and highly selective antagonist properties at the 5-hydroxytryptamine (5-ht, serotonin) 5-ht3 receptor. the selectivity ratio for ondansetron on 5-ht3 receptors compared with actions on other neurotransmitter receptor types is greater than 1,000. the antiemetic properties of ondansetron have been determined in ferrets against the nausea and vomiting induced by cisplatin, cyclophosphamide, and whole-body radiation. ondansetron (intravenous 0.01 to 0.1 mg/kg or su ... | 1992 | 1387245 |
| inhibition of cisplatin-induced emesis in ferrets by the non-nmda receptor antagonists nbqx and cnqx. | the excitatory amino acid (eaa) receptor antagonists, 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(f)quinoxaline (nbqx) and 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx), which preferentially block non-n-methyl-d-aspartate (non-nmda) subtypes of eaa receptors, effectively inhibit cisplatin-induced emesis in ferrets. a high dose of cisplatin (10 mg/kg i.v.) was used which induced emesis in all saline-treated control ferrets. at 10 mg/kg i.v., nbqx totally prevented cisplatin-induced emesis in 5 of 6 fer ... | 1992 | 1350077 |
| evaluation of plasma cortisol and corticosterone responses to synthetic adrenocorticotropic hormone administration in ferrets. | plasma cortisol and corticosterone responses of 8 clinically normal adult ferrets to synthetic acth (cosyntropin) were evaluated. cosyntropin was administered iv at 4 dosages (0.5, 1.0, 5.0, and 10 micrograms/kg of body weight) at 2- to 4-week intervals, with blood samples collected 60 and 120 minutes after injection. after completion of the studies, an additional acth stimulation test was performed by administering cosyntropin (1.0 micrograms/kg) im. the baseline plasma cortisol concentrations ... | 1993 | 8427469 |
| [clinical pharmacology of ondansetron]. | ondansetron (ods) is a new carbazole which exerts selective and potent antagonism on serotoninergic neurotransmission at serotonin 3 (5-ht3) receptors. animal and clinical studies show that ods reduces the incidence and severity of nausea and vomiting induced by cytotoxic drugs and radiotherapy. the antiemetic properties of this agent have been determined in ferrets against the nausea and vomiting induced by cisplatin, cyclophosphamide and whole-body radiation. the current hypothesis is that the ... | 1993 | 8372609 |
| changes induced in the representation of auditory space in the superior colliculus by rearing ferrets with binocular eyelid suture. | there have been conflicting reports concerning the importance of visual experience in the development of auditory localization mechanisms. we have examined the representation of auditory space in the superior colliculus of adult ferrets that were visually deprived by binocular eyelid suture from postnatal days 25-28, prior to natural eye opening, until the time of recording. this procedure attenuated the transmission of light by a factor of a least 20-25 and blurred the image so that, as long as ... | 1993 | 8359258 |
| a technique for catheterization of ferrets for chronic intratracheal material administration. | a method was needed for repeated administration of a liquid surfactant suspension into the lungs of nonrodent animals for the purpose of safety testing. catheters were implanted surgically into the tracheas of 66 juvenile ferrets and exteriorized at the back of the neck. after the ferrets had recovered from surgery, liquid was administered via the catheters into the ferrets' tracheas multiple times, for periods up to 1 month. ferrets were conscious and free-breathing during the intratracheal adm ... | 1993 | 8231092 |
| mechanisms of cisplatin- and m-chlorophenylbiguanide-induced emesis in ferrets. | we investigated the involvement of peripheral and central serotonin (5-ht)3 receptors in cisplatin- and 5-ht3 receptor agonist-induced emesis in ferrets. cisplatin (10 mg/kg i.v.)-induced emesis was inhibited by intravenous ym060 (0.003-0.1 microgram/kg). a highly selective and potent 5-ht3 receptor agonist, m-chlorophenylbiguanide (1-10 mg/kg i.p.), dose dependently elicited emesis an effect which was inhibited by ym060 (0.003-0.3 microgram/kg i.v.). vagotomy markedly reduced this emesis, and t ... | 1993 | 8405104 |
| effect of hyperammonemia on brain amino acids in young and adult ferrets. | effects of arginine deficiency and hyperammonemia on the brain concentrations of amino acids and urea cycle enzyme activities in young and adult ferrets were investigated. only young ferrets developed hyperammonemia and encephalopathy immediately after consuming the arginine-free diet. brain ornithine and citrulline concentrations in young ferrets fed arginine containing diet were significantly lower than those in adult ferrets. compared to rats and other animals, young and adult ferrets had low ... | 1993 | 24190672 |
| dose-ranging antiemetic evaluation of the serotonin antagonist rg 12915 in patients receiving anticancer chemotherapy. | rg 12915 is a potent, selective 5-ht3 receptor antagonist with a biologic half-life of 11-20 hours. rg 12915 prevents cisplatin-induced emesis in ferrets at doses of 0.03 mg/kg. animal toxicology studies permitted safe testing in humans at doses of up to 2.0 mg/kg. this dose-ranging trial of intravenous rg 12915 was performed to determine the optimal dosage and adverse effects and to observe for antiemetic effects in patients receiving anticancer chemotherapy. | 1993 | 8402492 |
| plasticity of autonomic control of emesis in irradiated ferrets. | to investigate the plasticity of the emetic response to irradiation, five groups of ferrets (with the appropriate controls) had either the vagal or the splanchnic nerves transected and either were immediately irradiated under urethan anesthesia or were irradiated in a conscious state at 0.5-4, 4-9, and 24 h and 7 days after nerve transection. all the ferrets used in this study had the left carotid artery and the right jugular vein catheterized several hours before irradiation so that blood press ... | 1993 | 8238610 |
| hypokalemia downregulates cardiac alpha 1 and skeletal muscle alpha 2 isoforms of na+,k(+)-atpase in ferrets. | k+ deficiency decreases amount of na+,k(+)-atpase in cardiac and skeletal muscle (sm) and differentially regulates alpha- and beta-subunit isoforms. expression of the alpha 3 isoform during k+ deficiency is unknown, however. in the myocardium of normal adult ferrets, alpha 1 and alpha 3 isoforms are expressed. therefore, we examined in ferrets the effects of k+ deficiency in levels of alpha- and beta-subunit isoforms. a k+ deficient diet greatly reduced plasma k+ concentrations. tissue k+ conten ... | 1993 | 8216318 |
| oestrus control in ferrets. | 1993 | 8236646 | |
| experimentally induced visual projections to the auditory thalamus in ferrets: evidence for a w cell pathway. | we have previously reported that following specific neonatal brain lesions in ferrets, a retinal projection is induced into the auditory thalamus (sur et al., science 242:1437, '88). in these "rewired" ferrets, a novel visual pathway is established through auditory thalamus [the medial geniculate nucleus (mgn)] and primary auditory cortex (a1); cells in both mgn and a1 are visually responsive and exhibit properties similar to those of visual cells in the normal visual pathway. in this paper, we ... | 1993 | 8366196 |
| interactions of oral beta-carotene and canthaxanthin in ferrets. | interactive effects of an oral dose of equal quantities of beta-carotene and either canthaxanthin or lycopene on serum and tissue beta-carotene accumulations were investigated in domestic ferrets. like humans, ferrets absorb a substantial portion of ingested beta-carotene intact and accumulate it in tissues. after the ferrets ingested a low carotenoid purified diet for 13 d, they were randomly assigned to one of two groups of six animals. one group was dosed with beta-carotene (10 mg/kg body wei ... | 1993 | 8336211 |
| auditory brainstem responses in ferrets following unilateral cochlear removal. | to examine the effect of unilateral or asymmetric hearing loss on the developing brain, ferrets had the right cochlea removed at postnatal day (p)5, p25, p40 or p90. auditory brainstem responses (abr) to free-field click stimulation were obtained before and after cochlear removal in the p40 and p90 groups, and from p28 in the other groups. acute cochlear removal did not lead to any change in the morphology of the abr waveform or to any change in the abr threshold in response to stimulation on th ... | 1993 | 8376212 |
| the effects of monocular enucleation on ganglion cell number and terminal distribution in the ferret's retinal pathway. | anterograde and retrograde tracing techniques were used to examine the effects of removing one eye at birth on the remaining uncrossed retinal pathway in adult ferrets. after enucleation, the adult number of labelled ganglion cells projecting ipsilaterally changed from an average of 6068 in normal pigmented ferrets to an average of 7813 (29% increase) in pigmented enucleates. the change in albino ferrets was from 1455 in normals to 2319 in enucleates (59% increase). labelled cells scattered acro ... | 1993 | 8261115 |
| the development of retinal ganglion cell decussation patterns in postnatal pigmented and albino ferrets. | the decussation patterns of retinal ganglion cells in postnatal pigmented and albino ferrets were examined by using retrograde axonal tracers. following unilateral injections into the optic pathway of newborn pigmented ferrets, approximately 13,000 cells were labelled in the ipsilateral retina. the majority (11,500) of these were located in temporal retina. postnatally, the numbers of cells projecting ipsilaterally from temporal retina fell by 49%. high rates of loss were observed in both the sm ... | 1993 | 7505166 |
| veterinary care for ferrets. | 1993 | 8460467 | |
| dendritic development in the dorsal lateral geniculate nucleus of ferrets in the postnatal absence of retinal input: a golgi study. | in order to determine the ongoing role of retinal fibers in the development of dorsal lateral geniculate nucleus (dlgn) neurons during postnatal development, the development of dlgn neurons in the postnatal absence of retinal input was studied in pigmented ferrets using the golgi-hortega technique. the development of four dlgn cell classes, defined on the basis of somatic and dendritic morphology, was described previously in normal ferrets (sutton and brunso-bechtold, 1991, j. comp. neurol. 309: ... | 1993 | 8492109 |