Publications

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pharmacokinetics and efficacy of an ivermectin implant for long-term prevention of dirofilaria immitis infection in dogs.an exploratory study was carried out to assess the in vivo efficacy of different prototypes of subcutaneous implants containing ivermectin (ivm) for the prevention of canine dirofilaria immitis infection. the implants consisted of an ethylcellulose matrix containing ivm (3.0, 4.5, and 6.0 mg/implant; from 0.29 to 0.63 mg/kg bw) as active ingredient designed to release approximately 0.1 ng of ivm/ml in the plasma for at least 12 months. six dogs were implanted on day -365. on day -12, three heart ...201728432479
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