Publications

stuttering, sickling, and cerebral malaria: a possible organic basis for stuttering.		1982	6123022
visual in-vitro test for determining the drug sensitivity of plasmodium falciparum.		1982	6123641
chloroquine-resistant falciparum malaria in semi-immune african tanzaniana.		1982	6123770
antimalarial activity of mefloquine and qinghaosu.		1982	6124713
in vitro mefloquine resistant plasmodium falciparum from the philippines.		1982	6124728
prostacyclin in falciparum malaria.		1982	6125752
abo blood groups in malaria and schistosomiasis haematobium.	we sought to determine if there was any relationship between abo blood groups and susceptibility to malaria and urinary schistosomiasis. in epe and outlying villages in south-western nigeria, we examined 681 people for their blood groups, malaria parasitemia and for the presence of schistosoma haematobium eggs in their urine specimens. two hundred and sixty-nine individuals were parasitemic for falciparum malaria, 97 subjects had urinary schistosomiasis and 56 people carried concurrent infection ...	1982	6126100
airport malaria in belgium.		1982	6126742
glycophorin as a possible receptor for plasmodium falciparum.	human red cells deficient in glycophorin b are partly resistant to invasion by plasmodium falciparum and become completely resistant when glycophorin a is removed from their surface by trypsin treatment. similar treatment of cells which have a hybrid glycophorin molecule renders them glycophorin-deficient and resistant to invasion. tn and wrb -ve cells with defined alterations in glycophorin a or b are also resistant to invasion. these findings suggest that both glycophorins a and b are involved ...	1982	6127459
falciparum malaria despite pyrimethamine/suifadoxine in five tourists to east africa.		1982	6127518
possible role of drug malabsorption in recrudescence of falciparum malaria.		1982	6128470
type ii mefloquine resistance in thailand.		1982	6128616
immunity to asexual erythrocytic stages of plasmodium falciparum: role of defined antigens in the humoral response.		1982	6174413
[exo-erythrocytic schizogony of plasmodium falciparum in the monkey cebus apella (author's transl)].	p. falciparum sporozoïtes obtained by membrane-feeding of anopheles stephensi with blood containing gametocytes were injected intravenously to the monkey cebus apella. 5 days later, a great number of exo-erythrocytic stages were found in the liver, and appeared to be morphologically similar to those described in man. the host specificity of the sporozoïte seems less restricted than that of the merozoïte.	1982	6178483
circulating interferon in patients with plasmodium falciparum, p. ovale and p. vivax malaria.		1982	6180528
translation in vitro of rna from the human malarial parasite plasmodium falciparum.	rna has been isolated from the human malarial parasite, plasmodium falciparum, and translated in vitro using two systems: rabbit-reticulocyte lysate and xenopus laevis oocytes. polypeptides are synthesized that are characteristic of the parasite isolate and the developmental stage from which the rna was purified. many of these polypeptides are precipitated by antibody from an immune monkey. analysis of the primary structure of these polypeptides should give the information necessary to produce a ...	1982	6182932
[anti-plasmodium falciparum monoclonal antibodies. preliminary results].	p. falciparum grown in culture was used to immunize mice and to obtain hybridomas. two hybrids were selected secreting high titers of monoclonal antibodies directed against the cytoplasm of erythrocytic forms of the plasmodium and not against the membrane of normal or parasitized erythrocytes. such antibodies are of potential value in the immuno-diagnosis of malaria.	1982	6183726
plasmodium falciparum merozoites: isolation by density gradient centrifugation using percoll and antigenic analysis.	merozoites of plasmodium falciparum were isolated and immunocytochemically analyzed. mature parasites from knobby (k+) and knobless (k-) strains were incubated for 4 to 5 hr in rpmi 1640 with 10% serum and 10% rbc extract. about 12 to 14% of the merozoites released were recovered by density gradient centrifugation using percoll. from 1 to 3 x 10(9) merozoites were obtained per collection. the merozoite preparations were contaminated with 10% residual bodies, about 0.1% infected and uninfected er ...	1982	6184466
protective antibodies against erythrocytic stages of plasmodium falciparum in experimental infection of the squirrel monkey, saimiri sciureus.	serum and ascitic fluid from squirrel monkeys (saimiri sciureus) inoculated with erythrocytic stages of plasmodium falciparum were collected at different periods of the infection. protection against p. falciparum was achieved by passive transfer of the sera or fluid recovered from animals after spontaneous or drug-induced cure. purified immunoglobulins from the ascitic fluid also conferred protection. in contrast, protective antibodies directed against erythrocytic stages of p. falciparum could ...	1982	6185908
antigenic differences among isolates of plasmodium falciparum demonstrated by monoclonal antibodies.	hybridomas raised against two papua new guinea (png) isolates of plasmodium falciparum secreted monoclonal antibodies which bound to schizonts of all seven png isolates tested but not to schizonts of four non-png isolates from thailand, nigeria, ghana, and the netherlands. some of the monoclonal antibodies were tested for their ability to inhibit the growth of one png isolate, one thai isolate, and one nigerian isolate in vitro. only the growth of the png isolate was inhibited, thus demonstratin ...	1982	6185427
determination of malarial antibodies by means of screening and differentiating antigens.	4455 human sera with malarial antibodies were analysed with regard to their reactivity to screening antigens (plasmodium fieldi and p. falciparum) and to differentiating antigens (p. vivax, p. ovale and p. malariae/brasilianum). results were obtained by indirect fluorescent antibody test. the identification rate of antibodies was significantly higher with p. fieldi than with p. falciparum antigen, and was lowest for both of the screening antigens in sera with antibodies to p. ovale. the highest ...	1982	6184910
comparison of various serological test results using antigens from different strains of plasmodium falciparum.	suitability of different strains of plasmodium falciparum grown continuously in vitro was compared using the indirect haemagglutination (iha) the indirect immunofluorescent (ifa) tests and elisa. in the tests employing soluble antigens (iha and elisa), there was a significant higher mean log titer of the same sera tested against different strains. ranking of the strains in term of sensitivity for the detection of malaria antibody in people in the endemic area were g-112 = so = cc greater than su ...	1982	6183756
antigenic diversity in the human malaria parasite plasmodium falciparum.	monoclonal antibodies against blood forms of plasmodium falciparum were used to demonstrate considerable antigenic diversity in this species. different isolates were distinguished by their ability to react with certain antibodies, and most of the antibodies reacted specifically with merozoites, schizonts, or both. the distribution of different antigenic types appeared not to be related to geographic origin. serological typing with monoclonal antibodies extends the range of methods for identifica ...	1982	6178159
malaria and the red cell.		1982	6129468
a radical interpretation of immunity to malaria parasites.	asexual forms of malaria parasites in erythrocytes are sensitive to oxidant stress. immunity to these parasites is thymus-dependent and may be mediated by the blinding of effector cells (macrophages or natural killer cells) to the surface of parasitised cells, with concomitant production of the superoxide anion (o2-). this can lead to degeneration of parasites in erythrocytes. antibodies can facilitate the binding of effector cells to parasitised erythrocytes, reinforcing the effects of cell-med ...	1982	6129509
inhibition of the in vitro growth of plasmodium falciparum by d vitamins and vitamin d-3 derivatives.	d vitamins are effective inhibitors of the in vitro intraerythrocytic growth of plasmodium falciparum. disappearance of the parasitemia was observed after 48 h contact between infected cells and 5 x 10(-6) m 1 alpha-hydroxycholecalciferol, 5 x 10(-5) m 25-hydroxycholecalciferol (25-oh-d-3), 1 alpha, 25-dihydroxycholecalciferol or 2.5 x 10(-4) vitamin d-2 and d-3. a 48 h pretreatment of healthy erythrocytes with 5 x 10(-5) m 25-oh-d-3 did not change their susceptibility to invasion by the parasit ...	1982	6283344
enzymes of purine and pyrimidine metabolism from the human malaria parasite, plasmodium falciparum.	plasmodium falciparum trophozoites were isolated by mechanical rupture of infected human erythrocytes followed by a series of differential centrifugation steps. after lysis with sonication, the 100 000 x g supernatant of parasites and uninfected host cells was used to determine the specific activities of a number of enzymes involved in purine and pyrimidine metabolism. p. falciparum possessed the purine salvage enzymes: adenosine deaminase, purine nucleoside phosphorylase, hypoxanthine-guanine p ...	1982	6285190
a rapid method for concentrating schizont-infected red cells of plasmodium falciparum.		1982	6302922
expression of strain-specific surface antigens on plasmodium falciparum-infected erythrocytes.	antigenic determinants present on the surface of squirrel monkey erythrocytes infected with late developmental stages of p. falciparum were recognized through their ability to bind antibodies present in the serum of immune monkeys. two different assays were used to demonstrate the presence of these antigenic determinants on the cell surface: the fluorescent labelling of intact cells in suspensions and the binding to protein a-sepharose. such determinants appear to be strain-specific and have, fo ...	1982	6185907
the establishment of genomic dna libraries for the human malaria parasite plasmodium falciparum and identification of individual clones by hybridisation.	the dna of plasmodium falciparum has been purified and fragmented with the restriction endonucleases ecori and hindiii. the fragments have been incorporated in vitro into derivatives of bacteriophage lambda to make libraries in which most of the parasite dna is represented. by southern hybridisation we have been able to recover from these libraries specific clones containing (a) repetitive dna sequences, (b) rrna gene(s) and (c) sequences homologous to an actin gene probe. parasite dna from two ...	1982	6213858
single-dose treatment of falciparum malaria with mefloquine: field studies with different doses in semi-immune adults and children in burma.	different doses of mefloquine (20 and 30 mg/kg of body weight in children, and 750 and 1000 mg in adults) were tested in controlled clinical trials in 89 children and 60 adults who were semi-immune carriers of plasmodium falciparum. there was no significant difference in the efficacy of the two doses, either in the children or in the adults. an ri-type resistance was found in 1 adult, when recrudescence occurred on day 7, and in 4 children, who showed recrudescence on day 14. in all 5 patients, ...	1982	6218927
conditions favoring gametocytogenesis in the continuous culture of plasmodium falciparum.		1982	6290655
activity of ketoconazole and its deacyl derivative against plasmodium falciparum and candida isolates.	deacylketoconazole was 15- to 50-fold more active against plasmodium falciparum than was ketoconazole, based on [(3)h]hypoxanthine uptake and quantitative parasite counts. in contrast, there were no significant differences between these drugs in their activity against clinical isolates of candida spp.	1982	6295271
the genome of plasmodium falciparum. i: dna base composition.	some structural properties of the dna of plasmodium falciparum were studied thoroughly using several techniques. its g+c content was found to be extremely low (17-19%), the lowest reported for a living organism. the dna seems to be composed only of the four major bases as no methylated bases were detected. this dna had a tm value of 62.5 degrees c and its denaturation profile showed no marked intramolecular heterogeneity.	1982	6278419
concentration of plasmodium falciparum-infected erythrocytes by density gradient centrifugation in percoll.		1982	6281409
[effect in vitro of artemisinine and its derivatives on plasmodium falciparum (author's transl)].		1982	6214149
mitogenic activity of extracts from continuous cultures of plasmodium falciparum.	studies were initiated to determine whether or not transformation of lymphocytes isolated from individuals functionally immune to malaria would be a useful tool for the identification of protective antigens derived from continuous cultures of plasmodium falciparum. soluble antigen preparations stimulated lymphoproliferative responses in cells isolated from immune and nonimmune individuals. to rule out the possibility that those nonspecific responses were mixed lymphocyte reactions or other, unde ...	1982	6211106
[autochthonous plasmodium falciparum malaria and the malarial liver].	when p. falciparum malaria is diagnosed in france in a patient who has not travelled to an endemic area, transmission by blood transfusion or direct contact with an infected person, and indigenous malaria should be considered. with reference to the observation reported in this paper, the manifestations of malarial hepatitis are recalled and their diagnostic significance is discussed. in p. falciparum malaria, malarial hepatitis indicates the development of a complete cycle including the pre-eryt ...	1982	6291168
the immunogenicity of malarial antigen obtained from infected human placenta.	malarial placenta antigen (mpa) was obtained from heavily parasitized human placenta. the immunogenicity of this antigen was tested by immunizing rabbits. the rabbit antiserum to malarial placenta antigen (anti-mpa) was absorbed with homogenate from nonparasitized human placenta. the anti-mpa serum was also absorbed with malarial placenta extract. evaluation of the anti-mpa serum was done using the ouchterlony immunodiffusion technique and by immunoelectrophoresis in agar. the results show that ...	1982	6307027
review of data on susceptibility of mosquitoes in the ussr to imported strains of malaria parasites.	studies on the susceptibility of mosquitos in the ussr to imported species and strains of human malaria parasites have revealed that anopheles atroparvus, a. messeae, and a. sacharovi are highly susceptible to strains of plasmodium vivax from africa, asia, and south america. there was no significant variation in the level of adaptation to the various vector species.in experiments on infection of a. atroparvus and a. messeae with imported strains of p. falciparum from africa and southern asia, al ...	1982	6761003
epidemiology: malaria 1980.		1982	6802318
plasmodium falciparum malaria in nigerians who live in britain.		1982	6802368
plasmodium falciparum malaria in nigerians who live in britain.		1982	6804003
fatal falciparum malaria and the availability of parenteral antimalarial drugs in hospitals.		1982	6805600
delayed diagnosis of malaria.		1982	6805629
fatal falciparum malaria and the availability of parenteral antimalarial drugs in hospitals.		1982	6805705
incipient resistance of plasmodium falciparum to chloroquine among a semi-immune population of the united republic of tanzania. 2. the impact of chloroquine used as a chemosuppressant on the immune status of the population.	decreased sensitivity and incipient resistance of plasmodium falciparum strains to chloroquine have been reported from mto-wa-mbu, in the north-east of the united republic of tanzania. in this locality the population had been exposed to chloroquine pressure for about two decades, in the form of medicated salt and through easy availability of the drug itself. in an attempt to find out whether such chemosuppression had influenced the immune response of the population, two seroepidemiological surve ...	1982	6761004
an evaluation of five regimens for the outpatient therapy of falciparum malaria in thailand 1980-81.	five regimens for the radical treatment of falciparum malaria were compared in five geographically separate areas of thailand. the cure rate for sulfadoxine-pyrimethamine was found to be low in the area of the kampuchean border and in the northeastern and western parts of the country. this distribution may be related to the spread of resistant parasites through the migration of labourers. a 7-day course of quinine was found to be uniformly effective, with an overall cure rate of 90% in these pri ...	1982	6761005
quinine by intravenous infusion for falciparum malaria.		1982	6809115
chemoprophylaxis of malaria in africa: the spent "magic bullet".		1982	6809183
pernicious syndromes in plasmodium infections.	records of 560 male patients with plasmodium vivax and p. falciparum infection, who were admitted to a military hospital in the northeastern sector of india during the period from june, 1978, to june, 1980, have been analysed to establish the prevalence of pernicious syndromes. one hundred and seventy-eight patients (31.8%) had p. vivax malaria, 309 (55.1%) had p. falciparum malaria, and the remaining 73 (13.1%) were found to have mixed infection (p. vivax and p. falciparum). pernicious syndrome ...	1982	6761563
antimalarial activity of selected aromatic chelators. iii. 8-hydroxyquinolines (oxines) substituted in positions 5 and 7, and oxines annelated in position 5,6 by an aromatic ring.		1982	6811856
the treatment and control of parasitic diseases.	in many parts of world, transmission of malaria due to plasmodium falciparum can no longer be controlled by insecticides. furthermore, this species has developed an amazing capacity for resistance to polyvalent drugs. the advent of new drugs and the possibility of developing a vaccine offer some hope for control of falciparum malaria. the fact that the spread of many parasitic diseases is promoted by contaminated water supplies resulting from inadequate waste disposal raises important questions ...	1982	6812199
dexamethasone deleterious in cerebral malaria.		1982	6812711
chemoprophylaxis of malaria in africa.		1982	6812805
chemoprophylaxis of malaria in africa.		1982	6814658
dexamethasone deleterious in cerebral malaria.		1982	6814688
[sero-immunologic diagnosis of malaria. methods and applications].		1982	6815403
[qinghaosu and its derivatives].		1982	6815404
malaria control and national health goals. report of the seventh asian malaria conference.		1982	6815902
plasmodium falciparum cultivation in vitro with fresh rabbit serum.		1982	6817990
prevention of malaria in travelers 1982.		1982	6818450
imported malaria in adults in auckland.	malaria is an increasing hazard of tropical travel. sixty-five cases were notified to the health department in 1980 and there is clear evidence of under notification. we reviewed the notes of 19 adults admitted to the infectious disease unit, auckland hospital, between 1 january 1979 and 31 march 1982. the typical patient admitted is a young caucasian new zealander presenting three months after returning from papua new guinea where he took prophylaxis: he is febrile, infected with p. vivax, has ...	1982	6761610
evaluation of a crude soluble antigen from in-vitro culture of plasmodium falciparum for elisa.	the present study was to evaluate the soluble antigen prepared from the in-vitro cultured p. falciparum (fcr3) as an alternative source of antigen to those obtained from in-vivo models for enzyme linked immunosorbent assay (elisa) in serology of malaria. results obtained on known positive and negative reference sera revealed good correlation between the elisa and the indirect fluorescent antibody (ifa) technique (rs = 0.797; p less than 0.001). however such close correlation was not observed on ...	1982	6761915
[resistance of plasmodium falciparum to fansidar, quinine and tetracycline].		1982	6762641
chloroquine and quinine resistant plasmodium falciparum on the island of mindoro, philippines, 1982.	a field study was conducted on the island of mindoro, republic of the philippines in which over 800 persons were screened for malaria and approximately 8% were found positive. the in vitro microtechnique was used to test for sensitivity to chloroquine, amodiaquine, mefloquine and quinine in 20 slide-confirmed p. falciparum cases. sixteen of these cases were also followed for in vivo chloroquine sensitivity. four cases showed in vitro resistance to chloroquine; 2 also showed resistance to quinine ...	1982	6763355
[what is safe in the prophylaxis and therapy of malaria?].		1982	6761299
quinine sensitivity of plasmodium falciparum in phra phutthabat hospital. a retrospective study.		1982	6761405
chloroquine-resistant plasmodium falciparum malaria in vanuatu.	cases of malaria caused by plasmodium falciparum resistant to chloroquine treatment have been probably occurring in vanuatu for many years. in this survey, seven patients with p. falciparum malaria were investigated for evidence of resistance to chloroquine. in-vitro resistance to chloroquine was demonstrated in four. two further patients who had clinical resistance to chloroquine treatment developed cerebral malaria. it is of interest that one of these patients was subsequently successfully tre ...	1982	6761561
inadequate prophylaxis of plasmodium falciparum malaria with once-a-week maloprim therapy.		1982	6761562
[current status of the physiopathology of pernicious malaria attacks].	the understanding of the pathophysiology of cerebral malaria has much benefited from the modern techniques of in vitro cultivation of plasmodium falciparum and from a better knowledge of the biology of the parasite. the demonstration of the existence of "knob-like protrusions" explains some of the processes giving way to changes in the deep capillaries of viscera and particularly of brain. in a synthetic view one can say that this localized vasculopathy is the main factor of the pathologic chang ...	1982	6755141
[drug resistance of plasmodium falciparum. analysis of factors in its appearance and spread].	after recalling the biochemical and genetic mechanisms of p. falciparum chemo-resistance, the authors report on an analytic study of the factors ruling the apparition and diffusion of resistant strains. the phenomenon is of chromosomic origin. the repetitive and high doses of drugs exert a pressure on the strains which is the main factor for revealing the selecting resistant mutants. other facilitating factors may operate such as a lack of immunity of the considered population, a possible partic ...	1982	6755142
[curative treatment of malaria plasmodium falciparum, p. vivax and p. ovale malaria with mefloquine].	mefloquine (wr 142-490, ro 21.5998), and antimalarial 4-quinoleine-methanol, active on multiresistant strains of p. falciparum is a resourceful product because of its pharmacocinetics and the possibility it opens of a single day curative therapy. its mean half-live is 15 days, with important individual variations from 8 to 23 days as well as racial one within north-american, asiatic or african patients. a 1,25 to 1,50 g dose divided in 2 or 3 intakes during 16 hours has proved to be effective in ...	1982	6755143
[malaria--also a problem in our country].		1982	6761681
comparison of in vitro pyrimethamine assays and in vivo response to sulphadoxine-pyrimethamine in plasmodium falciparum from papua new guinea.	the in vitro pyrimethamine sensitivity of 20 plasmodium falciparum isolates from papua new guinea children was determined. the children were treated with sulphadoxine-pyrimethamine and six were found to have clinically resistant malaria. the p. falciparum isolated from these subjects were more resistant to pyrimethamine in vitro than 13 of the isolates from sensitive cases. these results suggest that pyrimethamine sensitivity alone may be a good indicator of in vitro response to sulphadoxine-pyr ...	1982	6761908
cultivation of fertile plasmodium falciparum gametocytes in semi-automated systems. 1. static cultures.	a semi-automated cultivation apparatus for the in vitro culture of plasmodium falciparum gametocytes is described. this apparatus has been designed to produce large numbers of fertile sexual stages for use in the development of a gamete vaccine or for the infection of suitable mosquitoes. these mosquitoes in turn may be used for the development of a possible sporozoite vaccine. loss of red cells during medium change has been eliminated and the addition of warmed fresh medium simplified compared ...	1982	6761910
plasmodium falciparum merozoite vaccination in aotus monkeys recovered spontaneously from p. falciparum infection: a clinical study.	6 aotus trivirgatus monkeys, which had all spontaneously recovered from an experimentally induced plasmodium falciparum infection, were included in a clinical study concentrating on possible adverse reactions caused by a vaccine using late schizonts and merozoites as an antigen a synthetic compound, cp-20,961, as an adjuvant. two monkeys in the study were vaccinated once, 2 twice, 1 received adjuvant alone and 1 served as a saline control. local and general inflammatory reactions as indicated by ...	1982	6755660
[a preliminary survey of sensitivity of plasmodium falciparum to chloroquine by in vitro microtechnic in china].		1982	6762283
[clinical observations on pyronaridine phosphate by intravenous drip for the treatment of malaria].		1982	6762285
a preliminary survey of malaria in occidental, mindoro, philippines.	a survey of malaria in northwest mindoro, occidental, mindoro, philippines is reported. three species of human plasmodia were identified from 600 blood films examined. the overall prevalence of malaria was 7% (2.8% p. falciparum, 4.3% p. vivax, 0.7% p. malariae). the prevalence of malaria was highest (24%) among children 0 to 15 years of age and only 4 cases (12%) were found among persons over the age of 15. males and females were equally infected. study sites with the highest slide-positivity r ...	1982	6755740
[chloroquine resistant falciparum malaria in east africa illustrated by a case of cerebral malaria].		1982	6762686
[chloroquine resistant falciparum malaria in east africa].		1982	6762687
a clinico--haematological profile of malaria.		1982	6763036
diminished red blood cell deformability in uncomplicated human malaria. a preliminary report.	six patients with active p. falciparum malaria (two resistant to chloroquine therapy), one with treated and apparently cured p. falciparum malaria, one with active p. vivax malaria and two controls from the same geographic area of amazonian brazil were studied. all malaria patients had impaired red cell deformability. this was not correlated with drug resistance or number of parasitized cells. the hypothesis is presented that the presence of parasites in red blood cells and related metabolic eff ...	1982	6763070
[autoimmune hemolytic anemia in plasmodium falciparum malaria in a cameroonese child].		1982	6763193
red cell acetylcholinesterase activity in plasmodium falciparum malaria.	red cell ache activity was determined in 19 patients with p. falciparum malaria, 13 patients during convalescence as well as in 6 normal subjects. there was no significant difference between the mean values of ache in red cells of these 3 groups. after separation these blood samples into 2 portions by centrifugation in 5% ficoll solution, the parasitized red cells in the lower portion which are mostly ring forms contained the same amount of ache activity as those of the normal subjects and the n ...	1982	6755742
evaluation of the antimalarial activity of the phenanthrenemethanol halofantrine (wr 171,669).	halofantrine (wr 171,669) was administered to 27 nonimmune subjects infected with the multi-drug resistant vietnam smith strain of plasmodium falciparum. it was also administered to three other subjects, one infected with the cambodian buchanan strain of p. falciparum, and two with blood-induced infection with the chesson strain of p. vivax. it cured infections with all three parasites. against the highly chloroquine-resistant smith strain, it was curative in single day treatment regimens. the d ...	1982	6756175
[circulating immune complexes in 3 parasitic diseases: trichinosis, bilharziasis and malaria].		1982	6756252
susceptibility of anopheles gambiae to plasmodium yoelii nigeriensis and plasmodium falciparum.		1982	6763502
marker enzymes of plasmodium falciparum and human erythrocytes as indicators of parasite purity.	plasmodium falciparum trophozoites, isolated by mechanical rupture of infected human erythrocytes, were analyzed for purity by determination of the specific activities of a number of marker enzymes selected for high activity, stability, and convenience of assay procedures. the specific activities of the soluble enzymes lactate dehydrogenase and malate dehydrogenase were much higher in the parasite than in the erythrocyte. the soluble enzyme glutamate dehydrogenase (nadp+) was specific for the pa ...	1982	6757398
the purification of gametocytes of plasmodium falciparum and p. yoelii nigeriensis by colloidal silica (percoll) gradient centrifugation.	percoll gradient centrifugation has been applied to plasmodium falciparum- and p. yoelii-infected blood to allow rapid concentration of gametocytes. in the case of cultured p. falciparum, stage iv and v gametocytes were separated from immature stage ii and iii forms and concentrated from initial gametocytaemias of 1 to 3% to an average of greater than 80% and a maximum of 100% purity in a fraction which collected at the 1.064/1.083 g/ml interface; the rounded gametocytes of p. yoelii-infected mo ...	1982	6763789
[plasmodium falciparum malaria transmitted through human contact in a group of drug addicts].	the authors describe a case of malaria from p. falciparum occurred in a group of young drug-addicts. noteworthy is the fact that such a way of transmission did never occur before in italy. current concepts in treatment of malaria are briefly reviewed.	1982	6757799
malaria epidemiology and detectability.	conventional malaria surveys based on the microscopic examination of blood do not always detect chronic, low-grade infections caused by immunity. a model incorporating differences in detectability within the host population shows how the false negative tests caused by poor detectability confound measures of prevalence and the rates of infection and recovery. the model can also use multiple surveys on one group of individuals to estimate roughly the true prevalence. the form of data required is t ...	1982	6758220
spring transmission of malaria in alwar region (rajasthan).		1982	6759566
evaluation of cultured p. falciparum antigen in malaria indirect immunofluorescence test.		1982	6764217
placental pathologic changes in malaria. a histologic and ultrastructural study.	placenta malarial changes (pmcs) related to maternal plasmodium infection were present in 33% (247 cases) of a series of 741 placentas collected from an unselected population living in an area of high malarial endemicity (haut-ogooué, gabon, africa). plasmodia were found on material thick blood films taken at the time of delivery in 42% of the women with and 24% of women without associated pmcs. plasmodium falciparum was the most frequent infecting organism. pmcs were more frequent and, in gener ...	1982	6758604
[disseminated intravascular coagulation aa a complication of falciparum malaria].		1982	6764266
[malaria in the municipality of humaitá, state of amazonas. xiii - use of clindamycin in the treatment of patients with plasmodium falciparum infection].		1982	6764284
malaria at humaita county, amazonas state, brazil. xvi - gametocytes and lymphocytes studied in patients with plasmodium falciparum.		1982	6764285
[treatment of malaria (p. falciparum) with clindamycin. ii - dosage schedule for 5 days].		1982	6764286