Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| reduced incidence of stress ulcer in germ-free sprague dawley rats. | recent findings with respect to the role of spiral gram-negative bacteria in peptic ulcer disease have stimulated interest in discerning the role of these agents in stress ulcer disease. we tested the hypothesis that a standard restraint-cold ulcerogenic procedure would fail to produce ulcers in axenic rats. axenic, as well as normal sprague dawley rats, were exposed to a cold-restraint procedure. the germ-free condition was maintained throughout the study in the axenic rats. axenic rats had sig ... | 1993 | 8366772 |
| evaluation of new therapy for eradication of h. pylori infection in nude mouse model. | developing a new therapy for eradication of h. pylori by using the nude mouse model. | 1993 | 8362832 |
| studies on the mechanism of action of colloidal bismuth subcitrate. i. interaction with sulfhydryls. | the present study was designed to examine the reaction pathway of colloidal bismuth subcitrate (cbs) with thiols. studies were performed using the monothiol glutathione (gsh), the dithiol dithiothreitol (dtt) and the thiol enzymes papain and h+/k(+)-atpase. uv-vis spectra showed that cbs forms complexes with gsh and dtt. the gsh/cbs complex but not the dtt/cbs complex was cleared by 5,5'-dithiobis-(2-nitrobenzoic acid). cbs inhibited h+/k(+)-atpase (ic50: 23 +/- 6.5 mumol/l) but failed to inhibi ... | 1993 | 8395060 |
| the association of helicobacter pylori with differentiated-type early gastric cancer. | recent studies have indicated that infection with helicobacter pylori is closely associated with increased risk for gastric cancer. previous studies, however, usually have been made on cases of advanced gastric cancer. | 1993 | 8364862 |
| [helicobacter pylori and hiv infection]. | 1993 | 8399480 | |
| evaluation of new antiinfective drugs for helicobacter pylori infection: revisited and updated. | 1993 | 8399892 | |
| effect of helicobacter pylori colonization on quantitative distribution of antral g-cells in apparently healthy subjects and in duodenal ulcer patients. a morphometric study. | to investigate whether antral colonization by helicobacter pylori (hp) modifies gastrin-cell population, the number of g-cells was evaluated in antral biopsy specimens from 22 apparently healthy subjects and from 48 duodenal ulcer patients using a morphometric method. the level of serum immunoreactive gastrin in a sample of fasting serum obtained at the time of biopsy was also measured. in healthy subjects the g-cell count (evaluated according to g/i index) and the serum gastrin levels were not ... | 1993 | 8400368 |
| helicobacter pylori and intestinal metaplasia: comparison between british and yemeni patients. | there have been suggestions linking gastric carcinoma with helicobacter pylori on the one hand and type iii intestinal metaplasia on the other hand. this study was aimed at investigating the relationship between intestinal metaplasia and its subtypes, and the presence or absence of h. pylori in gastric biopsies from two geographically different patient populations, one with a much higher prevalence of h. pylori than the other. antral biopsies from 179 british and 123 yemeni patients with dyspeps ... | 1993 | 8362833 |
| biochemical and histopathological aspects in duodenogastric reflux gastritis patients with or without prior cholecystectomy. | the aim of this study was to evaluate some biochemical and histopathological aspects in a group of patients with a view to identifying any differences depending on whether the pathology was associated with previous cholecystectomy or idiopathic. the study involved 23 patients (8 post-cholecystectomy cases and 15 ulcer-free dyspeptic patients) with the diagnosis of duodenogastric reflux gastritis confirmed by endoscopic histopathological evaluation. the following parameters were considered: 1. ph ... | 1993 | 8368047 |
| granulomatous gastritis: a morphological and diagnostic approach. | the final diagnosis of granulomatous gastritis is based on morphological findings and clinical and laboratory data. detailed analysis of the morphological features of the granulomas together with associated mucosal changes could generate more information on aetiology and pathogenesis. biopsies from 71 patients diagnosed as having granulomatous gastritis were reviewed. thirty-seven of these patients (52%) had crohn's disease. in 18 patients (25%) an isolated granulomatous gastritis was diagnosed. ... | 1993 | 8365714 |
| mnng-induced gastric carcinoma in ferrets infected with helicobacter mustelae. | n-methyl-n-nitro-n'-nitrosoguanidine (mnng) is a gastric carcinogen in several animal species and has been used in a number of systems to dissect the co-carcinogenic potential of various compounds in the induction of gastric adenocarcinoma. recent epidemiological evidence suggests that helicobacter pylori may play a role as a co-carcinogen in the etiology of this tumor in humans and we have been interested in developing an animal model to study this possibility. a related organism, h. mustelae, ... | 1993 | 8403224 |
| local gastric and serum amoxicillin concentrations after different oral application forms. | the high recolonization rate after monotherapy of helicobacter pylori-positive gastritis may be due to insufficient local drug concentrations. to investigate the role of local diffusion, we measured levels of amoxicillin, a drug with good in vitro activity against h. pylori, in the mucosa and serum. one gram of amoxicillin was given to healthy volunteers as a tablet (n = 6) or as water-dissolved, fizzing "tab" (n = 6). gastroscopy with biopsies from the antrum, corpus, and fundus was performed a ... | 1993 | 8363383 |
| [colloidal bismuth subcitrate and amoxicillin in the treatment of helicobacter pylori infection in children]. | we have analyzed the effect of treatment with colloidal bismuth subcitrate (cbs) and amoxicillin in a series of 60 children (age range: 2.9-18 years) infected by helicobacter pylori (hp). the following results were found: clinical remission 70%; endoscopic normalization 55%; histological normalization 61.6% and hp eradication 53.3%. the improvement of histological activity (100% vs 11.7%) and histological normalization (90.6% vs 28.5%) were significantly more frequent in the hp eradicated group ... | 1993 | 8368681 |
| one-day therapy for treatment of helicobacter pylori infection. | the present study evaluated the effect of a one-day high-dose combined therapy on helicobacter pylori infection. thirty-two consecutive patients (suffering from either peptic ulcer or nonulcer dyspepsia) with helicobacter pylori infection received omeprazole (40 mg) + bismuth subcitrate (240 mg x 4) + amoxicillin suspension (2000 mg x 4) + metronidazole (500 mg x 4), for only one day. endoscopy, histology, culture, and susceptibility studies were done at entry and 30 and 90 days after the treatm ... | 1993 | 8359079 |
| colloidal bismuth subcitrate, ranitidine, and ranitidine plus metronidazole in the treatment of duodenal ulcer and helicobacter pylori infection: a controlled and prospective study. | a controlled, prospective clinical trial of colloidal bismuth subcitrate (cbs), ranitidine and ranitidine plus metronidazole for the treatment of duodenal ulcer (du) is reported here, with evaluation of the possible pathogenic role of helicobacter pylori (hp) on du in a six-month follow-up. a total of 42 patients with active du on endoscopy were randomly selected to receive oral cbs (300 mg 1 hour before each meal, and at bedtime, n = 16), ranitidine (150 mg bid; n = 12) or ranitidine (150mg b.i ... | 1993 | 8364776 |
| in vitro susceptibility of helicobacter pylori to trospectomycin, pirlimycin (u-57930e), mirincamycin (u-24729a) and n-demethyl clindamycin (u-26767a). | the in vitro activity of trospectomycin, pirlimycin, mirincamycin and n-demethyl clindamycin was measured against 46 clinical isolates of helicobacter pylori using an agar dilution technique. the mic50 and mic90 were 4 and 64 micrograms/ml for pirlimycin and n-demethyl clindamycin, and 32 and 128 micrograms/ml for mirincamycin, respectively. all 46 strains were sensitive to trospectomycin with an mic50 of 8 micrograms/ml and an mic90 of 16 micrograms/ml. of seven strains with the highest trospec ... | 1993 | 8404921 |
| detection of immunoglobulin g antibodies to helicobacter pylori in urine by an enzyme immunoassay method. | urine and serum samples from 306 patients undergoing upper endoscopy were evaluated prospectively to determine the presence of immunoglobulin g (igg) antibodies to helicobacter pylori by an enzyme immunoassay method. forty-nine selected urine specimens were also tested by western blotting (immunoblotting). when compared with bioptic methods (culture, stain, urease testing), the sensitivity and specificity of the assay for urine igg to h. pylori were 95.9 and 90%, respectively. results of testing ... | 1993 | 8370747 |
| comparisons between degree of histological gastritis and dna fingerprints, cytotoxicity and adhesivity of helicobacter pylori from different gastric sites. | thirty-six isolates of h. pylori from up to three gastric biopsy sites (antrum, corpus and fundus) from 13 patients in italy with different degrees of histological gastritis were investigated. all strains were tested for motility, cytotoxicity and degree of adhesion, and were typed by analysis of ribosomal rna gene patterns (ribopatterns). seventeen different dna types (ribotypes) were identified, with each patient possessing h. pylori of one or more unique types. only two patients had identical ... | 1993 | 8405318 |
| [costs and effectiveness of diagnosis and treatment of patients with dyspepsia, determined with the aid of a computer model]. | a theoretical investigation was carried out to determine whether the use of an antibody test for helicobacter pylori (hp) and the use of bismuth oxide with optional antibiotics, would be cost effective in the diagnosis and treatment of patients with dyspepsia. with literature data on therapeutic effectiveness a computer simulation was carried out. a quick antibody test reduced the number of gastroscopic investigations necessary. gastroscopic investigation still had to be carried out for patients ... | 1993 | 8371821 |
| [ranitidine therapeutically effective in functional dyspepsia with reflux-like symptoms]. | to investigate the effect of ranitidine in patients with functional dyspepsia according to different subgroups. | 1993 | 8371822 |
| fluorinated probes to measure carboxylesterase activities using 19f nmr spectroscopy: application to erythrocytes and helicobacter pylori. | eight fluorinated compounds were tested as putative probes to measure carboxylesterase activity employing 19f nuclear magnetic resonance spectroscopy. the method takes advantage of the sensitivity of fluorine resonances to the changes in the chemical bonding in the covalent structures where they are located. determination of the kinetic parameters of ethyl fluoroacetate and diethyl fluoromalonate in hemolysates showed that these probes were well suited to study carboxylesterase activities in com ... | 1993 | 8373162 |
| [clinico-pharmacologic considerations in helicobacter pylori eradication therapy]. | problems and pitfalls of treatment regimens for eradication of helicobacter pylori (hp) are discussed from a clinical, pharmacological and microbiological point of view. problems concerning the physician who treats the patient consists mainly in inappropriate indication and suboptimal knowledge of drugs, doses and duration of therapy against hp. for successful triple therapy with complicated dosage protocols cooperation with and compliance by the patient is stressed. physicochemical, pharmacolog ... | 1993 | 8379234 |
| bacterial infections and gastrointestinal lymphomas. | 1993 | 8406427 | |
| [therapy of helicobacter pylori infection: current status]. | h. pylori is closely associated with gastritis, peptic ulcer disease and gastric cancer. a causative role of h. pylori is now established in type b gastritis, its role in non ulcer dyspepsia is unresolved. eradication of h. pylori results in a marked decrease of peptic ulcer relapse rates. gastric cancer risk is 2- to 8-fold increased if gastric mucosa is colonized by h. pylori. treatment of h. pylori infection is difficult although the organism is highly sensitive to several antibiotics in vitr ... | 1993 | 8379235 |
| helicobacter pylori infection. | the discovery of helicobacter pylori is arguably the most significant advance made in gastroduodenal pathology this century. it is the most important cause of chronic gastritis, and almost certainly the major aetiological factor responsible for duodenal ulcer and probably for gastric ulcer as well. evidence is accumulating which suggests that it may play an important role in the pathogenesis of gastric cancer. h. pylori is thought to be transmitted by the faecal-oral route or possibly oral-oral ... | 1993 | 8407699 |
| enhanced cultivation of helicobacter pylori in liquid media. | to evaluate a technique for culture of helicobacter pylori in large quantities of liquid media and to determine the factors that could influence the results. | 1993 | 8408702 |
| distribution of helicobacter pylori colonisation and associated gastric inflammatory changes: difference between patients with duodenal and gastric ulcers. | to determine the gastric distribution of helicobacter pylori in patients with duodenal and gastric ulcers; and to examine the mucosal inflammatory response. | 1993 | 8408703 |
| are routine duodenal and antral biopsies useful in the management of "functional" dyspepsia? a diagnostic and therapeutic study. | fifty-three patients with previously uninvestigated chronic dyspepsia symptoms in the absence of gastrointestinal or extra-gastrointestinal disease (functional dyspepsia) underwent antral and duodenal mucosal biopsies to detect the role of such samplings in the presence of normal endoscopic findings. patients were enrolled in a randomized, placebo-controlled, double-blind trial, receiving either eradicating treatment (colloidal bismuth subcitrate plus metronidazole) or placebo if they had helico ... | 1993 | 8409311 |
| prevalence of helicobacter pylori in brazilian patients with gastric carcinoma. | investigators have speculated on the role of helicobacter pylori in gastric carcinogenesis. the current study was performed to evaluate prospectively the prevalence of h. pylori infection in the stomachs of brazilian patients with gastric carcinoma. forty patients receiving gastrectomy for gastric carcinoma were studied. h. pylori was examined in four areas without atrophy or with minor atrophic changes. mucosal fragments were obtained for microbiologic studies in 19 cases. h. pylori was detecte ... | 1993 | 8379532 |
| an in vitro adherence assay reveals that helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium. | helicobacter pylori is a microaerophilic bacterium found in the stomach of asymptomatic humans as well as patients with acid peptic disease and gastric adenocarcinoma. we have developed an in situ adherence assay to examine the cell lineage-specific nature of binding of this organism and to characterize the nature of cell surface receptors that recognize its adhesin. fluorescein isothiocyanate-labeled h. pylori strains were bound to surface mucous cells present in the pit region of human and rat ... | 1993 | 8383333 |
| prevalence of helicobacter pylori in patients with chronic renal failure. | the prevalence of helicobacter pylori (h. pylori) was investigated in 164 consecutive patients with different degrees of renal function; group i (normal renal function) n = 84, group ii (chronic renal failure, clcr > or = 5 < 90 ml/min) n = 45, group iii (haemodialysis therapy) n = 35, to test the hypothesis that the resulting different concentrations of urea in the gastric juice would have an influence on the colonization of the gastric mucosa by these urea-splitting bacteria. as every individu ... | 1993 | 8390002 |
| [comparison of acid and helicobacter pylori in ulcerogenesis of duodenal ulcer disease]. | to test the efficacy of short-term ranitidine and antibacterial drugs in patients with h. pylori associated duodenal ulcer disease and to compare the importance of acid and h. pylori in ulcerogenesis, 90 outpatients were randomly assigned to one of five regimens: ranitidine, 150 mg in the morning and at bedtime; gentamicin, 40 mg tid; terramycin, 500 mg tid; furazolidone, 100 mg tid; or berberine, 300 mg tid. the patients were evaluated endoscopically, microbiologically and histologically before ... | 1993 | 8395315 |
| are routine cleaning methods sufficient to remove helicobacter pylori from endoscopic equipment? | 1993 | 8404717 | |
| transmission of helicobacter pylori by endoscopy? | 1993 | 8404718 | |
| cloning, expression and sequencing of helicobacter felis urease genes. | urease genes from helicobacter felis were cloned and expressed in escherichia coli cells. a genomic bank of sau3a-digested h. felis chromosomal dna was created using a cosmid vector. cosmid clones were screened for urease activity following subculture on a nitrogen-limiting medium. subcloning of dna from an urease-positive cosmid clone led to the construction of pill205 (9.5 kb) which conferred a urease activity of 1.2 +/- 0.5 mumole urea min-1 mg-1 bacterial protein to e. coli hb101 bacteria gr ... | 1993 | 8412683 |
| more on the eradication of helicobacter pylori and the recurrence of duodenal ulcer. | 1993 | 8413426 | |
| gastrospirillum hominis in a child with chronic gastritis. | 1993 | 8414788 | |
| helicobacter pylori and intestinal metaplasia: possible implications in gastric carcinogenesis. | 1993 | 8404719 | |
| growth of helicobacter pylori in media containing cyclodextrins. | we show that solid and liquid media, supplemented only with cyclodextrins and free of blood and its derivatives, support the growth of helicobacter pylori. these media can be used for primary isolation of the bacteria from biopsy samples, routine laboratory growth, and large-scale industrial fermentation. | 1993 | 8417026 |
| helicobacter pylori serology. | 1993 | 8417028 | |
| adherence of helicobacter pylori to cultured human gastric epithelial cells. | experiments were performed to demonstrate that adherence of helicobacter pylori to gastric epithelial cells causes alterations in the cell cytoskeleton. h. pylori intimately attached to cultured human gastric epithelial cells on small cellular projections, while there was no intimate association of h. pylori with cultured human esophageal epithelial cells. fluorescein-conjugated phalloidin staining of gastric epithelial cells showed that h. pylori adherence stimulated actin polymerization; this ... | 1993 | 8418061 |
| biotype and molecular fingerprints of metronidazole-resistant strains of helicobacter pylori from antral gastric mucosa. | biotypes, ribosomal rna gene restriction patterns (ribopatterns), whole-cell protein patterns and plasmid profiles of paired helicobacter pylori isolates from 17 patients were examined. each pair comprised a pre- and a post-treatment isolate; nine of the 17 post-treatment isolates were obtained after treatment with tripotassium dicitrate bismuthate (de-nol) and metronidazole. all strains of h. pylori had identical biotypes, but exhibited diversity between pairs in their molecular fingerprints. e ... | 1993 | 8418295 |
| helicobacter pylori infection: independent risk indicator of gastric adenocarcinoma. | helicobacter pylori has been implicated as a possible etiologic factor in gastric cancer. this case control study was performed to determine the association between h. pylori and gastric cancer, taking into account the possibility of confounding by other background factors. | 1993 | 8405854 |
| susceptibility of helicobacter pylori and pharmacokinetic properties in mice of new 5-nitroimidazole derivatives devoid of mutagenic activity in the ames test. | the minimum inhibitory concentrations of metronidazole and four new 5-nitroimidazole derivatives (eu 11100, eu 11102, eu 11103, eu 11104), obtained by the reaction of 1-methyl-5-nitroimidazolyl-2-carboxyaldehyde and terbutyl-phenol, were determined against 25 clinical isolates of helicobacter pylori. three of them (eu 11100, eu 11103, eu 11104) exhibited an antibacterial activity higher than that of metronidazole. the last one, the molecule eu 11102, was less active than metronidazole. in mice, ... | 1993 | 8371126 |
| effect of ranitidine and amoxicillin plus metronidazole on the eradication of helicobacter pylori and the recurrence of duodenal ulcer. | persistent infection with helicobacter pylori is associated with the recurrence of duodenal ulcer. whether the efficacy of bismuth therapy in reducing the rate of recurrence of duodenal ulcer is due to its antimicrobial effects on h. pylori or to a direct protective action on the mucosa is still a matter of debate. | 1993 | 8419816 |
| treatment of peptic ulcers caused by helicobacter pylori. | 1993 | 8419823 | |
| use of serum specific immunoglobulin antibodies to determine helicobacter pylori associated gastritis. | a prospective study in 169 consecutive patients referred for upper gastrointestinal endoscopy was initiated to investigate the diagnostic performance of serum helicobacter pylori (hp) specific immunoglobulin (ig) g antibodies. using an enzyme linked immunosorbent assay (elisa) an excellent correlation between serologic evidence of hp and the demonstration of this organism by histology and urease test in 79 hp-positive patients was found. serum igg also correlated with the histological degree and ... | 1993 | 8379229 |
| [prevalence of helicobacter pylori and gastritis in southern germany. results of a representative cross-sectional study]. | the recent discussions about the relationship between helicobacter-pylori-infection, gastritis and the occurrence of stomach cancer caused us to analyse blood sera of 543 participants randomly selected from the general population in the age of 25 to 34 and of 55 to 64 years from mosbach (neckar-odenwald-kreis), the county of deggendorf (lower-bavaria) and augsburg (upper-bavaria) regarding igg-antibodies against helicobacter pylori and the concentrations of the pepsinogens a and c. the latter we ... | 1993 | 8379230 |
| [qualitative and semiquantitative invasive and noninvasive diagnosis of helicobacter pylori colonization of gastric mucosa]. | in 110 patients with unknown helicobacter pylori status and without anti-bacterial treatment submitted for routine endoscopy of the upper gastrointestinal tract biopsies were taken from the antral and body mucosa, which were assessed for h. pylori colonisation and/or gastritis by an urease test (jatrox h. p.-test), microscopy after methylene-blue staining of a mucosal smear, specific culture and histology (stains: haematoxylin & eosin and warthin-starry). in addition, a simplified 13c-urea breat ... | 1993 | 8379231 |
| comparison of helicobacter pylori and attaching-effacing escherichia coli adhesion to eukaryotic cells. | adhesion of helicobacter pylori was reported previously to be morphologically identical to "attaching and effacing" escherichia coli. therefore, the aim of the present study was to define the adhesion phenotype of h. pylori lc-11 to hep-2, kato-iii, hel, and cho tissue culture cells. by using both staining of f-actin with fluorescein-labeled phalloidin and ultrastructural analysis, diffuse bacterial adhesion to discrete microvillus-denuded regions of the plasma membrane was observed in each of t ... | 1993 | 8380793 |
| effect of ph variation on the susceptibility of helicobacter pylori to three macrolide antimicrobial agents and temafloxacin. | the in vitro susceptibility of 27 clinical isolates of helicobacter pylori to erythromycin, clarithromycin, azithromycin and temafloxacin under various ph conditions was evaluated. clarithromycin (mic90 0.03 micrograms/ml) was found to be significantly more active than either erythromycin (mic90 0.125 micrograms/ml) or azithromycin (mic90 0.25 micrograms/ml) at a neutral ph. lowering the ph to 5.75 resulted in a loss in efficacy from 8- to 32-fold for all three macrolides studied. the mic90 of c ... | 1993 | 8388791 |
| enhanced gastric mucosal leukotriene b4 synthesis in patients taking non-steroidal anti-inflammatory drugs. | the effects of longstanding non-steroidal anti-inflammatory drug (nsaid) treatment on gastric mucosal synthesis of leukotriene b4 (ltb4), leukotriene c4 (ltc4), and prostaglandin e2 (pge2) was studied. gastric antral biopsies in 65 patients with arthritis taking nsaids and 23 control patients were taken and eicosanoid concentrations, stimulated by vortex mixing or calcium ionophore, were measured by radioimmunoassay. median gastric mucosal synthesis of ltb4 was increased in patients taking nsaid ... | 1993 | 8390958 |
| accuracy of a rapid 10-minute carbon-14 urea breath test for the diagnosis of helicobacter pylori-associated peptic ulcer disease. | urease in the human gastric mucosa is a marker for infection with helicobacter pylori (hp), an organism which is associated with peptic ulcer disease. to detect gastric urease, we examined 184 patients (144 males, 40 females; mean age: 49.8 +/- 15.6 years) with suspected peptic ulcer disease. fasting patients were given orally 5 microci of carbon-14 labelled urea. from each patient only one breath sample was collected in hyamine at 10 min. the amount of 14c collected at 10 min was expressed as f ... | 1993 | 8404959 |
| the relationship between helicobacter pylori and oxygen-derived free radicals in the mechanism of duodenal ulceration. | this prospective randomized study investigated the possibility that duodenal ulcer relapse associated with helicobacter pylori infection is mediated by oxygen-derived free radicals. to this end, the radical scavengers allopurinol (50 mg 4 times daily) and dimethyl sulphoxide (dmso, 500 mg 4 times daily) were administered orally. one hundred and forty-six consecutive patients with previous symptomatic endoscopy proven duodenal ulceration, which had been shown endoscopically to have healed in the ... | 1993 | 8400493 |
| anti-helicobacter pylori antibodies prevalence and gastric adenocarcinoma in portugal: report of a case-control study. | evidence from large cohort studies has established an increased risk of gastric cancer for individuals infected with helicobacter pylori (hp). in low incidence countries, like the united kingdom and sweden, case-control studies suggested that the prevalence of anti-hp antibodies in gastric cancer patients (at the time of cancer diagnosis) is greater than in control populations. we present results from a case-control study of the prevalence of igg anti-hp antibodies in gastric cancer patients and ... | 1993 | 8401171 |
| gastric cancer and helicobacter pylori infection. | 1993 | 8402077 | |
| [the diagnostic accuracy of gastric urease activity for helicobacter pylori]. | the diagnostic accuracy of gastric urease activity for helicobacter pylori (hp) infection were studied in 98 patients with peptic ulcer, gastritis and chronic renal failure. gastric aspirates were analyzed for urea nitrogen and ammonia. urease activity was calculated as the ratio of gastric ammonia to sum of gastric urea nitrogen and ammonia. gold standard assessments to hp infection were rapid urease test, histology and/or culture. the results showed that the values of urease activity in patien ... | 1993 | 8404318 |
| metronidazole-resistant helicobacter pylori in a developing country. | 1993 | 8424447 | |
| duodenal histology, ulceration, and helicobacter pylori in the presence or absence of non-steroidal anti-inflammatory drugs. | duodenitis and gastric metaplasia, which is often colonised by helicobacter pylori (h pylori), are increasingly recognised for their importance in the pathogenesis of duodenal ulcers. the situation is not clear in patients receiving non-steroidal anti-inflammatory drugs (nsaids), who have a higher risk of peptic ulceration. the aim of this study was to identify the duodenal histological abnormalities in the presence or absence of nsaids, h pylori, and duodenal ulceration. endoscopic duodenal bio ... | 1993 | 8406146 |
| amoxicillin plus omeprazole versus triple therapy for eradication of helicobacter pylori in duodenal ulcer disease: a prospective, randomized, and controlled study. | treatment with amoxicillin and omeprazole resulted in encouraging helicobacter pylori eradication rates in pilot studies that included medium term follow up. these results were evaluated in a prospective, randomised and controlled study. forty patients with active duodenal ulcer disease and h pylori colonisation of the gastric mucosa were randomly assigned to receive either omeprazole (20 mg twice daily) and amoxicillin suspension (500 mg four times daily) for two weeks (group i) or bismuth subs ... | 1993 | 8406147 |
| helicobacter pylori and peptic ulcer disease. | the role played by helicobacter pylori in the pathogenesis of peptic ulcer disease (pud) is discussed, and the epidemiology, identification, diagnosis, eradication, and treatment of h. pylori infection are reviewed. isolation of h. pylori from up to 100% of patients with duodenal ulcer and 80% of patients with gastric ulcer establishes a strong association between h. pylori and idiopathic pud, although other factors also may be essential for the development of pud. invasive procedures for diagno ... | 1993 | 8428432 |
| gastric adenocarcinoma with ciliated tumor cells. | ciliated metaplasia (cm) of gastric mucosa is common in japanese individuals but rare in whites. we studied 36 consecutive gastrectomies from chinese individuals for the presence of cm. the gastrectomies were performed for adenocarcinoma (n = 22), benign ulcer (n = 13), and malignant lymphoma (n = 1). ciliated metaplasia was found in 16 (44.4%) of the stomachs, with equal distribution between male and female patients. ciliated metaplasia was present in 11 cases (50%) of adenocarcinoma and in fiv ... | 1993 | 8406420 |
| adherence of helicobacter pylori to primary human gastrointestinal cells. | helicobacter pylori adheres only to gastric cells in vivo. however, the organism adheres to a wide variety of nongastric cells in vitro. in this study, we have used flow cytometry to assess the adherence of h. pylori to primary epithelial cells isolated from gastric, duodenal, and colonic biopsy specimens by collagenase digestion. after incubation of bacteria and cells together and subsequent staining with a two-stage fluorescein isothiocyanate-labelled h. pylori antibody method, cells with adhe ... | 1993 | 8406792 |
| endoscopy-negative dyspepsia. hold those forceps! | nonulcer dyspepsia (nud) is an enigmatic disorder which likely has heterogeneous etiologies. helicobacter pylori-associated gastritis has been identified in a large number of patients with nud, raising speculation that chronic infection with this organism may cause dyspepsia in some patients. prospective case-control and cohort studies however do not suggest that h. pylori prevalence is greater in nud than in asymptomatic controls. limited therapeutic trials of h. pylori-eradication therapy have ... | 1993 | 8409329 |
| development of a 14c-urea breath test in ferrets colonised with helicobacter mustelae: effects of treatment with bismuth, antibiotics, and urease inhibitors. | a 14c-urea breath test analogous to its clinical counterpart is described for use in ferrets naturally or experimentally infected with helicobacter mustelae. the test is performed within a sealed glass metabolism chamber through which air is drawn at a constant rate and expired breath collected into sodium hydroxide. peak 14co2 production occurred approximately 1 hour after substrate administration. both inter- and intra-animal responses were highly reproducible, with mean coefficients of variat ... | 1993 | 8432469 |
| experimental gastritis induced by helicobacter pylori in japanese monkeys. | we used japanese monkeys (macaca fuscata) to establish an experimental model in order to clarify the pathogenicity of helicobacter pylori in gastric and duodenal disorders. a suspension (5 ml; 10(9) cfu/ml) of h. pylori cells isolated from humans was sprayed around the antrum of the stomach of each of 12 of 17 animals with an endoscope. the remaining five animals were not inoculated; they served as a control group. on days 7, 14, and 28 after inoculation, the gastric mucosa samples were examined ... | 1993 | 8432614 |
| the helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin. | the gastric pathogen helicobacter pylori has been shown to produce a 19.6-kda protein with apparent binding activity for erythrocytes, human buccal epithelial cells, and laminin. in this report we demonstrate that it is an iron-binding protein, resembling ferritin both structurally and biochemically. also, because its binding activity for laminin, erythrocytes, and buccal cells was abolished by low concentrations of tween 20, binding is likely nonspecific. | 1993 | 8419304 |
| clinical relevance of gastrointestinal hormones: emerging interest in hypergastrinemia. | 1993 | 8420451 | |
| [helicobacter detected in children of helicobacter pylori-positive parents]. | the authors examined 48 children of helicobacter pylori positive parents: 52% were serologically positive for helicobacter pylori using the orion diagnostics pyloriset latex agglutination test. of these children 10 had upper abdominal pain, heartburn and acid eructation and osesophagogastroscopy was performed; seven were found to be helicobacter pylori positive histologically. these results draw attention to the transmission of helicobacter pylori infection within families. they suggest that the ... | 1993 | 8426729 |
| helicobacter pylori antibodies in areas of italy at varying gastric cancer risk. | in a survey of 930 adults aged 35-74 years randomly sampled from the general population of four areas of italy, two at low and two at high risk for gastric cancer, plasma levels of helicobacter pylori igg antibodies were assayed in order to investigate associations with the geographical distribution of gastric cancer and other dietary and life-style factors, as assessed by personal interview. h. pylori positivity (antibody titer above or equal to 10 micrograms/ml), 45% overall, increased with ag ... | 1993 | 8420610 |
| transformation of helicobacter pylori by electroporation. | a highly efficient method of introducing dna into an important human pathogen is reported here. electroporation-mediated transformation of a laboratory-passaged isolate of helicobacter pylori was successfully used to establish genetic mutants at a transformation frequency of > 10(5)/micrograms dna. this method should be widely applicable to all isolates of h. pylori and may eliminate the variability reported when natural transformation was used on fresh clinical isolates. | 1993 | 8431287 |
| [10 years helicobacter (campylobacter) pylori]. | 1993 | 8438600 | |
| [cytotoxic effect of ammonia produced by helicobacter pylori urease on the cultural cells]. | we investigated the action of the ammonia produced by helicobacter pylori urease on the cultured cells. the urease was purified from supernatant fluid of sonicated cell of h. pylori cultured on blood agar for 2 days at 37 degrees c under microaerophilic condition. purification was carried out by deae-sepharose chromatography, phenyl-sepharose chromatography, sephacryl s-200 sf chromatography and fast protein liquid chromatography on mono-q. vero, hela and intestin 407 cells with or without the a ... | 1993 | 8409583 |
| pathological case of the month. helicobacter pylori gastritis. | 1993 | 8438818 | |
| [anti-h. pylori antibodies of the patients with gastric cancer]. | 1993 | 8409587 | |
| [a study on the detection of helicobacter pylori in children with gastric and duodenal diseases]. | infection of hellcobacter pylori (h. pylori) in the gastric mucosa is said to participate in the pathogenesis of gastric and duodenal ulcers as well as gastritis. the detection rate of h. pylori in tissue specimens endoscopically taken from adult patients with these diseases was 75.2% (408/542). in affected children (2-15 yrs), on the other hand, 27 biopsies were performed in 22 cases but the initial positive rats was as low as 45.5%. according to the diagnosis, it was 75% for acute gastric muco ... | 1993 | 8409589 |
| study of helicobacter pylori colonization of patches of heterotopic gastric mucosa (hgm) at the upper esophagus. | helicobacter pylori (hp), known to cause active chronic gastritis, has primarily been found in gastric-type mucosa. even in the duodenum, the organism was detected in islands of metaplastic gastric mucosa. hp has also been found in gastric metaplasia of barrett's esophagus in 15-50%. the aim of our study was to determine: (1) the frequency with which hp is found on histopathological sections of heterotopic gastric mucosa (hgm) patch(es) at the upper esophagus, as compared to that of the stomach ... | 1993 | 8420747 |
| helicobacter pylori and gastroduodenal disorders in india--lessons from epidemiology. | the relationship of helicobacter pylori and gastroduodenal disorders should be compared in the developing (dg) and developed (dd) nations (table 1) for a better understanding of the etiopathogenesis of these disorders. although chronic gastritis is widespread in the dg nations, benign and malignant gastric ulcer (gu) are uncommon. repeated reinfections and longer duration of h. pylori infection in the fundus-body mucosa of patients with duodenal ulcer from the dg nations explain the lower values ... | 1993 | 8421150 |
| the 13c-urea breath test, helicobacter pylori infection, and the operated stomach. | 1993 | 8421157 | |
| the association of helicobacter pylori with gastric cancer and preneoplastic gastric lesions in chiapas, mexico. | helicobacter pylori recently was identified as a risk factor for gastric cancer. its association with preneoplastic conditions of the stomach, however, is undocumented. | 1993 | 8422620 |
| demonstration of helicobacter pylori in tracheal secretions. | a new gram-negative bacterium, helicobacter pylori, has been found in gastric secretions. in view of an almost 9% incidence of unidentified gram-negative bacteria in aspiration pneumonia, the authors set out to prove that h pylori could be found in tracheal secretions. eighteen sequential patients admitted to the intensive care unit who had endotracheal or nasogastric intubation for 24 hours or longer were studied. of 20 sets of specimens from 18 patients. helicobacter was recovered from 2(10%) ... | 1993 | 8423130 |
| ethnic differences in helicobacter pylori infection. | 1993 | 8444233 | |
| the e test for antimicrobial susceptibility testing of helicobacter pylori. | antimicrobial susceptibility testing of helicobacter pylori by conventional means (disc diffusion) is of questionable value because the bacterium grows so slowly. we have determined the susceptibilities of 20 isolates of h. pylori to ampicillin, erythromycin, gentamicin, metronidazole, rifampicin and tetracycline by the e test, a novel technique for measuring mics, and compared the results with those determined by standard agar dilution and disc diffusion methods. eighty-one per cent of e test-d ... | 1993 | 8444676 |
| nitroimidazole drugs--action and resistance mechanisms. i. mechanisms of action. | 1993 | 8444678 | |
| glucose phosphorylation in helicobacter pylori. | saccharide kinase activities in helicobacter pylori were investigated by incubating bacterial lysates with atp and mono- or disaccharides and monitoring directly the appearance of phosphorylated products using 13c or 31p nuclear magnetic resonance spectroscopy. the monosaccharides employed included two trioses, two tetroaldoses, one tetroketose, five aldopentoses, two ketopentoses, five aldohexoses, three ketohexoses, and gluconic and glucuronic acids; the disaccharides studied were maltose, tre ... | 1993 | 8424689 |
| [availability of determination of serum anti-helicobacter pylori igg antibody in diagnosis of helicobacter pylori infection]. | we studied on clinical availability of determination of serum anti-helicobacter pylori (hp) igg antibody in diagnosis of hp infection compared with bacterial culture. the population of this study consisted of patients who underwent endoscopic examination in our hospital. detection and quantification of hp were made by the culture of biopsy specimens taken from the antrum and the body of the stomach. and, simultaneously, serum anti-hp antibody (hp-ab) was measured by elisa. the levels of hp-ab in ... | 1993 | 8411745 |
| cigarette smoking and helicobacter pylori infection. | the direct urease test was used in 462 patients with normal upper digestive tracts, 108 with duodenal ulcers and 43 with gastric ulcers who attended for upper digestive endoscopy in a prospective study. there was a strong association between helicobacter pylori infection and current cigarette smoking in patients with normal endoscopy (49.6% vs 35.5%, p < 0.01). the associations of peptic ulcer both with h. pylori infection and cigarette smoking were also confirmed. the excess of peptic ulcer dis ... | 1993 | 8446549 |
| [association and concordance of parameters of helicobacter pylori infection of gastric antrum mucosa]. | 1993 | 8415437 | |
| gastric interleukin-8 and iga il-8 autoantibodies in helicobacter pylori infection. | gastric infection with helicobacter pylori is frequently characterized by neutrophil infiltration. the production of the neutrophil-activating peptide (nap-1/il-8) and mucosal iga autoantibodies to il-8 by human antral biopsies have been examined during short-term in vitro culture. detectable il-8 was secreted by 84% of h. pylori-negative patients with normal antral mucosa (range < 0.07-61.5 ng/mg biopsy protein, n = 19). concentrations in 4 patients with reactive gastritis and 10 with inactive ... | 1993 | 8418474 |
| link between helicobacter pylori-associated gastritis and duodenal ulcer. | we examined the interrelationships among the degree of fundic mucosal atrophy, the prevalence of helicobacter pylori in the gastric antrum, the gastric juice, and the duodenum with and without gastric metaplasia, in 20 duodenal ulcer patients and 20 non-duodenal ulcer patients. the detection rates of h. pylori in the antrum, the gastric juice, and the duodenum were significantly higher in duodenal ulcer patients (80%, 65%, and 60%) than in non-duodenal ulcer subjects (50%, 20%, and 5%). the freq ... | 1993 | 8420742 |
| paracrystalline inclusions of a novel ferritin containing nonheme iron, produced by the human gastric pathogen helicobacter pylori: evidence for a third class of ferritins. | an abundant 19.3-kda helicobacter pylori protein has been cloned, and the sequence is homologous with a ferritin-like protein produced by escherichia coli k-12. homologies are also present with a number of eucaryotic ferritins, as well as with the heme group-containing bacterioferritins. all amino acids involved in chelation of inorganic iron by ferritins from humans and other higher species are conserved in the h. pylori protein. consistent with the structural data indicating an iron-binding fu ... | 1993 | 8432720 |
| [antibacterial activity of cefdinir and omeprazole against helicobacter pylori and their inhibition on h. pylori-producing urease]. | since helicobacter pylori is isolated very frequently from gastric ulcer specimens, the combination therapy of antimicrobial agent and proton pump inhibitor has recently been used. a study was made on whether cefdinir (cfdn), amoxicillin (ampc), metronidazole (mnz), omeprazole (opz), and omeprazole-m (opz-m) have antimicrobial activity against h. pylori and whether they can inhibit h. pylori-producing urease. 1) cfdn, ampc and mnz showed a potent antimicrobial activity against h. pylori, and esp ... | 1993 | 8409593 |
| ammonium metabolism and protection from urease mediated destruction in helicobacter pylori infection. | to investigate further the intracellular ammonium metabolism of helicobacter pylori and the mechanism of its urease mediated destruction. | 1993 | 8432895 |
| high gastric juice ascorbic acid concentrations in members of a gastric cancer family. | gastric juice ascorbic acid, total vitamin c, nitrite and n-nitroso-compound concentrations were determined in fasting gastric juice from four second generation members of a gastric cancer family, all of whom had helicobacter pylori-associated chronic gastritis and intestinal metaplasia. juice ph, nitrite and n-nitroso-compound concentrations were low. juice ascorbate levels were comparable to those found in subjects with normal histology. the findings are contrary to our previous experience wit ... | 1993 | 8435869 |
| [is helicobacter pylori gastritis a macroscopic diagnosis?]. | in a prospective study, gastroscopy and biopsies from the gastric antrum and body were undertaken in 100 consecutive patients (67 women, 33 men; mean age 58.6 [11-90] years) with unknown helicobacter pylori status. none had been on any bacteria-suppressing drugs. main indications for gastroscopy were upper abdominal pain, dyspepsia, emesis and anaemia of unknown cause. the macroscopic criteria for the diagnosis of h. pylori gastritis were the presence of at least one of the following signs: (1) ... | 1993 | 8436066 |
| [peptic ulcer and helicobacter pylori. comments on the authors' cases]. | the presence of helicobacter was tested on a group with antral or duodenal ulcer with or without gastritis, versus a group without gastric or duodenal pathology. furthermore an open trial was performed between omeprazole and colloidal bismuth subcitrate (cbs) on patients similarly affected by peptic disease. although cbs did eliminate helicobacter in more than a half of patients, what was not obtained by omeprazole, this result did not mean a better control of peptic disease: in fact the omepraz ... | 1993 | 8430247 |
| [the effect of colloidal bismuth and its combination with amoxicillin on the elimination of helicobacter pylori in patients with a duodenal ulcer and chronic antral gastritis]. | although the aetiopathogenetic role of helicobacter pylori (hp) in duodenal ulcer and in chronic gastritis seems now well defined, we have not yet standardized therapeutic schedules to achieve disappearance of hp. this study was aimed at evaluating the efficacy of two different therapeutic schedules, colloidal bismuth alone [cb(1200 mg/day)], vs. association with amoxicillin [cb+a(3 g/day)] for six weeks, to clear hp from antral specimens in a cohort of dyspeptic patients. 49 consecutive patient ... | 1993 | 8430249 |
| common-sense management of helicobacter pylori-associated gastroduodenal disease. personal views. | we have tried to present a rational approach to the medical treatment of peptic ulcer disease and nonulcer dyspepsia in the era of h. pylori. we are aware that the natural history of peptic ulcer disease is still debated. some clinicians believe that peptic ulcer disease may "burn out" over a 10- to 15-year period, and in light of this, the emphasis toward a nonsurgical "cure" for peptic ulcer disease may seem misguided. yet, all factors must be taken into account. current medical therapy has de ... | 1993 | 8449567 |
| gastric bacteria other than helicobacter pylori. | since the culture of helicobacter pylori from the human stomach in 1983 there has been renewed interest in other bacteria that had been observed in animal stomachs as early as late in the nineteenth century. many of these bacteria have now been isolated and have been shown to belong to the same genus, helicobacter, which currently contains nine species. study of the gastric helicobacters is important because it provides relevant information about how bacteria can survive in the gastric environme ... | 1993 | 8449568 |
| pathology of the gastric antrum and body associated with helicobacter pylori infection in non-ulcerous patients: is the bacterium a promoter of intestinal metaplasia? | a series of 115 consecutive, non-ulcerous, dyspeptic patients were examined for helicobacter pylori (h. pylori) colonization in the gastric antral and/or body mucosa using giemsa staining. findings were correlated with the presence and degree of activity of superficial gastritis, deep gastritis, atrophic gastritis and with the presence of intestinal metaplasia. the prevalence of h. pylori positivity was 61.7%. in 59 of the 71 positive patients (83%), h. pylori was detected in the antrum or in bo ... | 1993 | 8436350 |