Publications

synthesis and antifungal activity in vitro of isoniazid derivatives against histoplasma capsulatum var. capsulatum.	histoplasmosis is a severe infection that affects millions of patients worldwide and is endemic in the americas. amphotericin b (amb) and itraconazole are highly effective for the treatment of severe and milder forms of the disease, but amb is toxic, and the bioavailability of itraconazole is erratic. therefore, it is important to investigate new classes of drugs for histoplasmosis treatment. in this study, a series of nine isoniazid hydrazone derivatives were synthesized and evaluated for their ...	2014	24514090
histoplasmosis infections worldwide: thinking outside of the ohio river valley.	in the united states, histoplasmosis is generally thought to occur mainly in the ohio and mississippi river valleys, and the classic map of histoplasmosis distribution reflecting this is second nature to many u.s. physicians. with the advent of the hiv pandemic reports of patients with progressive disseminated histoplasmosis and aids came from regions of known endemicity, as well as from regions not thought to be endemic for histoplasmosis throughout the world. in addition, our expanding armamen ...	2015	26279969
disseminated histoplasmosis partially mimicking a dermatomyositis in a patient with rheumatoid arthritis.	histoplasma capsulatum var. capsulatum is a dimorphic fungus endemic to america and subtropical regions. several cases of this opportunist mycosis have been reported in immunocompromised patients. we report the case of a patient treated with methotrexate and corticosteroid therapy for rheumatoid arthritis and who presented with disseminated histoplasmosis that partially mimicked a dermatomyositis.	2015	26197989
primary cutaneous histoplasmosis developed in the penis of an immunocompetent patient.	a 70-year-old male presenting a 3-month history of genital painless erythematous nodules in the balanopreputial sulcus was referred to our service. histopathological exam presented a chronic dermatitis with epithelioid granulomas and grocott staining revealed numerous fungal structures with a suggestive morphology of histoplasma sp. cultures evidenced histoplasma capsulatum var. capsulatum. treatment with oral itraconazole led to complete remission of lesions.	2015	25831000
fluorescent in situ hybridization of pre-incubated blood culture material for the rapid diagnosis of histoplasmosis.	fluorescence in situ hybridization (fish) has been shown to be useful for the detection of candida and cryptococcus species in blood culture materials. fish procedures for the detection of histoplasma capsulatum var. capsulatum have not been reported so far. this study describes the development and evaluation of fluorescently labeled rrna-targeting fish probes to detect and identify h. capsulatum in blood cultures. all three analyzed h. capsulatum reference strains and clinical isolates showed p ...	2015	25537280
[clustered cases of histoplasmosis due to histoplasma capsulatum var. capsulatum in martinique: case reports and environmental investigation].	between the 24th of june and the 6th of july 2005, nine men came to fort-de-france emergency department (martinique, french west indies) with more or less pronounced pulmonary symptoms associated in two cases with skin lesions. three weeks before these nine men performed work in a deserted house. the diagnosis of histoplasmosis was based on pulmonary sample mycological analysis (direct examination and culture), molecular biology and serological tests. interrogatory and environmental investigatio ...	2016	27727098
histoplasma capsulatum infection with extensive lytic bone lesions mimicking lch.	multiple lytic bone lesions in a child can be a manifestation of various diseases like langerhans cell histiocytosis, metastatic neuroblastoma, leukemia, hyperparathyroidism, multifocal osteomyelitis and histoplasmosis. disseminated histoplasmosis caused by histoplasma capsulatum var. duboisii is well known to present with multiple osteolytic lesions in immunocompromised adults and is mostly restricted to the african subcontinent. histoplasmosis seen in american and asian countries is caused by ...	2016	27329388
antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against histoplasma capsulatum strains in vitro.	recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. this study investigated the in vitro susceptibility of histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. the susceptibility assay was performed according to clinical and laboratory standards institute guidelines. all strains were inhibited by the protease ...	2016	26748233
histoplasma capsulatum-induced cytokine secretion in lung epithelial cells is dependent on host integrins, src-family kinase activation, and membrane raft recruitment.	histoplasma capsulatum var. capsulatum is a dimorphic fungus that causes histoplasmosis, a human systemic mycosis with worldwide distribution. in the present work, we demonstrate that h. capsulatum yeasts are able to induce cytokine secretion by the human lung epithelial cell line a549 in integrin- and src-family kinase (sfk)-dependent manners. this conclusion is supported by small interfering rna (sirna) directed to α3 and α5 integrins, and pp2, an inhibitor of sfk activation. sirna and pp2 red ...	2016	27148251
amplification of blood smear dna to confirm disseminated histoplasmosis.	the prevalence of the histoplasma capsulatum var. capsulatum (hcc) histoplasmosis may be underestimated west africa, both because the diagnosis is not mentioned in the early stages of the disease and due to limited biological resources available.	2017	28214953
unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy.	histoplasmosis is the most common endemic mycoses among hiv-infected people. patients with suppressed cell immunity mainly due to hiv are at increased risk of disseminated disease. dermatological manifestations of immune reconstitution inflammatory syndrome (iris) and cutaneous manifestations of histoplasmosis similar to an iris event have been previously described. we report the case of a 43-year-old male who presented with cutaneous disseminated histoplasmosis due to histoplasma capsulatum var ...	2017	28210571
a case of orbital histoplasmosis.	histoplasma capsulatum var capsulatum is a dimorphic fungus endemic to the ohio and mississippi river valleys of the united states. in this case report, a 33-year-old woman who presented with a right orbital mass causing progressive vision loss, diplopia, and facial swelling is described. lateral orbitotomy with lateral orbital wall bone flap was performed for excisional biopsy of the lesion. the 1.5 × 1.8 × 2.3 cm cicatricial mass demonstrated a granulomatous lesion with necrosis and positive s ...	2017	25186215