Publications

whole genome sequencing analysis of the cutaneous pathogenic yeast malassezia restricta and identification of the major lipase expressed on the scalp of patients with dandruff.	malassezia species are opportunistic pathogenic fungi that are frequently associated with seborrhoeic dermatitis, including dandruff. most malassezia species are lipid dependent, a property that is compensated by breaking down host sebum into fatty acids by lipases. in this study, we aimed to sequence and analyse the whole genome of malassezia restricta kctc 27527, a clinical isolate from a korean patient with severe dandruff, to search for lipase orthologues and identify the lipase that is the ...	2017	27882618
proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of malassezia sympodialis.	complete and accurate genome assembly and annotation is a crucial foundation for comparative and functional genomics. despite this, few complete eukaryotic genomes are available, and genome annotation remains a major challenge. here, we present a complete genome assembly of the skin commensal yeast malassezia sympodialis and demonstrate how proteogenomics can substantially improve gene annotation. through long-read dna sequencing, we obtained a gap-free genome assembly for m. sympodialis (atcc 4 ...	2017	28100699
identification of small rnas in extracellular vesicles from the commensal yeast malassezia sympodialis.	malassezia is the dominant fungus in the human skin mycobiome and is associated with common skin disorders including atopic eczema (ae)/dermatitis. recently, it was found that malassezia sympodialis secretes nanosized exosome-like vesicles, designated malaex, that carry allergens and can induce inflammatory cytokine responses. extracellular vesicles from different cell-types including fungi have been found to deliver functional rnas to recipient cells. in this study we assessed the presence of s ...	2017	28051166
curdlan induces selective mast cell degranulation without concomitant release of ltc4, il-6 or ccl2.	mast cells are sentinel cells with a tissue-specific localization in the interface between the host and the external environment. their quick and selective response upon encountering pathogens is part of the innate host response and typically initiates the following adaptive immune response. among several pattern recognition receptors (prrs) involved in the recognition of pathogens by mast cells, the c-type lectin receptor dectin-1 has been associated with the recognition of fungi. our previous ...	2017	27989425