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multidrug-resistant corynebacterium striatum endocarditis successfully treated with daptomycin. 201222817918
[a corynebacterium striatum endocarditis on a carrier of pacemaker].we report a new case of a corynebacterium striatum endocarditis on a carrier of a pacemaker. corynebacterium striatum was isolated from blood culture, the pulse generator and the pacing lead. a literature review of corynebacterium striatum endocarditis on a carrier of pacemaker was conducted.201222565181
identification and diversity of multiresistant corynebacterium striatum clinical isolates by maldi-tof mass spectrometry and by a multigene sequencing approach.the genus corynebacterium is composed of gram-positive bacteria that are widely distributed throughout the environment; these bacteria are also part of the normal microbiota of human skin and mucous membranes. multiple studies have shown that species of this genus, including c. striatum, become pathogenic to humans under special conditions. our aim was to determine the characteristics of clinical multiresistant strains of c. striatum that were isolated in our geographical region, to determine th ...201222475029
non-diphtheriae corynebacterium species: an emerging respiratory pathogen.the purpose of the study was to describe the microbiological and clinical features of ten cases of lower respiratory tract infection due to corynebacterium striatum, corynebacterium propinquum and corynebacterium pseudodiphtheriticum. respiratory samples were recovered from hospitalised patients who were diagnosed of pneumonia and exacerbations of chronic respiratory infections. the samples were gram-stained and seeded on conventional bacterial growing media. bacteria were identified by matrix-a ...201223271676
sonication of explanted cardiac implants improves microbial detection in cardiac device infections.the sonication technique has been shown to be a promising tool for microbiological diagnosis of device-related infections. we evaluated the usefulness of the sonication method for pathogen detection in 80 explanted cardiac components collected from 40 patients, and the results were compared with those of conventional cultures. forty subjects undergoing cardiac device removal were studied: 20 had cardiac device infection, and 20 subjects underwent elective generator replacement or revision in the ...201323196364
clonal multidrug-resistant corynebacterium striatum within a nosocomial environment, rio de janeiro, brazil.corynebacterium striatum is a potentially pathogenic microorganism with the ability to produce outbreaks of nosocomial infections. here, we document a nosocomial outbreak caused by multidrug-resistant (mdr) c. striatum in rio de janeiro, brazil. c. striatum identification was confirmed by 16s rrna and rpob gene sequencing. fifteen c. striatum strains were isolated from adults (half of whom were 50 years of age and older). c. striatum was mostly isolated in pure culture from tracheal aspirates of ...201323440110
comparison of the staphylococcus quickfish bc test with the tube coagulase test performed on positive blood cultures for evaluation and application in a clinical routine setting.many studies demonstrate that delayed proper therapy in bloodstream infections caused by staphylococcus aureus increases the mortality rate, emphasizing the need to shorten the turnaround time for positive blood cultures. different techniques are currently available, from phenotypic methods to more complex tests such as matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof), real-time pcr (rt-pcr), and fluorescence in situ hybridization using peptide nucleic aci ...201323100336
about a bloodstream corynebacterium striatum isolate.corynebacterium striatum is often dismissed as a contaminant when cultivated from blood samples; indeed, it is a skin saprophyte that may therefore be introduced into the clinical specimen accidentally. nevertheless, the organism can be responsible for true bacteraemias, and multidrug resistance spread among nosocomial strains is of increasing concern. specific criteria for testing have not been defined yet, but we however suggest to report clear resistances (i.e. absence of any inhibition zones ...201323397249
corynebacterium striatum: an emerging nosocomial drug-resistant endocardial pathogen.endocarditis due to corynebacterium striatum has been rarely reported. a 78-year-old patient developed pacemaker endocarditis caused by multidrug-resistant c. striatum, complicated by vertebral osteomyelitis and epidural abscess. daptomycin therapy successfully eradicated the bacteremia and metastatic infection. a review of the english literature on this emerging nosocomial, multidrug-resistant pathogen is included.201324151771
[corynebacterium striatum]. 201323940879
septic arthritis of the shoulder due to corynebacterium striatum. 201323688845
epidemiological investigation of a nosocomial outbreak of multidrug-resistant corynebacterium striatum at one belgian university hospital.during an 8-month period, 24 corynebacterium striatum isolates recovered from lower respiratory tract specimens of 10 hospitalized patients were characterized. the organisms were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) and by 16s rrna gene sequencing. the cluster of c. striatum exclusively affected patients who had been admitted to an intensive care unit and/or subsequently transferred to one medium-size respiratory care unit. pro ...201423586637
quadricuspid aortic valve complicated with infective endocarditis: report of a case.congenital quadricuspid aortic valve is a rare cardiac malformation with an unknown risk of infective endocarditis. we report a case of quadricuspid aortic valve complicated with infective endocarditis. a 53-year-old japanese woman was hospitalized with leg edema and a fever of unknown origin. corynebacterium striatum was detected in the blood culture. echocardiography demonstrated a quadricuspid aortic valve with vegetation and severe functional regurgitation. the condition was diagnosed as a q ...201424496979
[drug susceptibility and homologous analysis on corynebacterium striatum strains isolated from inpatients].to explore the molecular epidemiological features and in vitro susceptibility profile of corynebacterium striatum strains isolated from different sites of inpatients, and further provide new data and idea for clinicians to better get knowledge of the clinical significance of corynebacterium striatum.201425410920
respiratory infection by corynebacterium striatum: epidemiological and clinical determinants.the increasing prevalence of advanced chronic respiratory disease, with frequent exposure to broad-spectrum antibiotics for repeated and prolonged hospitalizations, favours the emergence of nosocomial respiratory infection by gram-positive bacteria, such as outbreaks of corynebacterium striatum. there is little evidence about patterns of respiratory infection, transmission and adaptive ability of this pathogen. seventy-two c. striatum isolates from 51 advanced respiratory patients, mainly chroni ...201425356355
corynebacterium striatum: an emerging nosocomial pathogen in a case of laryngeal carcinoma.corynebacterium striatum is an emerging nosocomial pathogen associated with wound infections, pneumonia and meningitis. it is also a multidrug-resistant pathogen causing high morbidity. this is a report of an unusual case of wound infection in a patient with laryngeal carcinoma. accurate diagnosis of the infection and prompt management helped in a favourable outcome for the patient. this case highlights the role of c. striatum as an important nosocomial pathogen in immunocompromised patients.201425008830
septic arthritis of a native knee joint due to corynebacterium striatum.we report a case of septic arthritis of a native knee joint due to corynebacterium striatum, a rare and unusual cause of septic arthritis of native joints. the isolate was identified by a combination of phenotypic, mass spectrometric, and nucleic acid-based assays and exhibited high-level resistance to most antimicrobials.201424574280
antimicrobial activity of chemokine cxcl10 for dermal and oral microorganisms.cxcl10 (ip-10) is a small 10 kda chemokine with antimicrobial activity. it is induced by ifn-γ, chemoattracts mononuclear cells, and promotes adhesion of t cells. recently, we detected cxcl10 on the surface of the skin and in the oral cavity. in the current study, we used broth microdilution and radial diffusion assays to show that cxcl10 inhibits the growth of escherichia coli, staphylococcus aureus, corynebacterium jeikeium, corynebacterium striatum, and candida albicans hmv4c, but not coryneb ...201425859394
rapid emergence of daptomycin resistance in clinical isolates of corynebacterium striatum… a cautionary tale.the objective of this study was to investigate the observation of daptomycin resistance in corynebacterium striatum, both in vivo and in vitro. we describe a case of c. striatum bacteremia in a patient with a left ventricular assist device (lvad); the initial isolate recovered was daptomycin susceptible with a minimum inhibitory concentration (mic) of 0.125 μg/ml. two months later, and after daptomycin therapy, the individual became bacteremic with an isolate of c. striatum with a daptomycin mic ...201424973133
aac(3)-xi, a new aminoglycoside 3-n-acetyltransferase from corynebacterium striatum.corynebacterium striatum bm4687 was resistant to gentamicin and tobramycin but susceptible to kanamycin a and amikacin, a phenotype distinct among gram-positive bacteria. analysis of the entire genome of this strain did not detect any genes for known aminoglycoside resistance enzymes. yet, annotation of the coding sequences identified 12 putative acetyltransferases or gcn5-related n-acetyltransferases. a total of 11 of these coding sequences were also present in the genomes of other corynebacter ...201526149994
multidrug-resistant corynebacterium striatum bacteremia: first case in korea. 201526131424
urethritis due to corynebacterium striatum: an emerging germ.corynedbacterium striatum (cs) is a gram-positive coryneform bacillus that is part of mucous and skin flora. it has been considered as a causative agent of many infections in intensive care, neurology, traumatology and urology, but was never implicated in non-gonococcal urethritis. we report the case of a nosocomial urethritis due to corynebacterium striatum following resection of an intrameatus condyloma.201525955369
biofilm production by multiresistant corynebacterium striatum associated with nosocomial outbreak.corynebacterium striatum is a potentially pathogenic microorganism that causes nosocomial outbreaks. however, little is known about its virulence factors that may contribute to healthcare-associated infections (hais). we investigated the biofilm production on abiotic surfaces of multidrug-resistant (mdr) and multidrug-susceptible (mds) strains of c. striatum of pulsed-field gel electrophoresis types i-mdr, ii-mdr, iii-mds and iv-mds isolated during a nosocomial outbreak in rio de janeiro, brazil ...201525946249
draft genome sequence of corynebacterium striatum 1961 br-rj/09, a multidrug-susceptible strain isolated from the urine of a hospitalized 37-year-old female patient.corynebacterium striatum commonly colonizes the normal skin and nasopharyngeal tract of humans; however, this potentially pathogenic bacterium has been identified as the causative agent of several nosocomial infections. the current study describes the draft genome of strain 1961 br-rj/09, isolated from the urine of a hospitalized patient from brazil.201526251495
central venous catheter-related bloodstream infection by corynebacterium striatum identified by 16s rrna and rpob gene sequencing. 201526206696
relapsing bacteraemia due to corynebacterium striatum in a patient with peripheral arterial disease.we describe the first reported case of corynebacterium striatum (c. striatum) relapsing bacteraemia in a patient with peripheral arterial disease and proven corynebacterium species colonization of a chronic foot ulcer, focusing on the difficulties in the management of the patient. we conclude that the optimal duration of the antibiotic treatment for relapsing c. striatum bacteraemia from a chronic ulcer should be 6 weeks together with surgical treatment.201526638539
management of a patient with small-area burns, severe sepsis and superficial vein thrombosis.sepsis is frequently seen in severely burned patients, however it is not common in those with small-area burns. we present a case of a 22-year-old man suffering from a hot crush injury to his left hand dorsum covering 1% of his total body surface area. the patient developed severe sepsis and superficial vein thrombosis, probably due to wound infection. culture of the wound secretion indicated corynebacterium striatum. following intensive topical and systemic treatment the severe sepsis was contr ...201525647435
emergence of high-level daptomycin resistance in corynebacterium striatum in two patients with left ventricular assist device infections.we describe the clinical and microbiologic courses of two patients with ventricular assist device infections secondary to corynebacterium striatum treated with daptomycin. in both cases, the pathogen was initially susceptible to daptomycin (minimum inhibitory concentration [mic] <0.125 mg/l) but became resistant (mic >256 mg/l) during therapy.201626544621
[native valve endocarditis due to corynebacterium striatum; report of a case].we recently encountered a case of native valve endocarditis caused by corynebacterium striatum (c. striatum) in the absence of immunosuppression and a prosthetic valve. a 49-year-old woman was urgently admitted for disturbance of consciousness and nosebleeds. careful clinical examination revealed infective endocarditis caused by c. striatum, for which replacement of aortic and mitral valves was performed. the postoperative course was favorable, and we were able to save the patient with no postop ...201627220933
cellulitis and bacteremia due to corynebacterium striatum identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry.corynebacterium striatum has been described as a pathogen in immunocompromised patients; however, correctly identifying corynebacterium spp. is often difficult, and cases of cellulitis caused by c. striatum are only rarely reported. we herein describe a case of cellulitis and bacteremia due to c. striatum identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry. antimicrobial susceptibility testing was performed using the strepto-haemo supplement method, and van ...201627150881
corynebacterium striatum empyema and osteomyelitis in a patient with advanced rheumatoid arthritis.corynebacterium striatum, which is a common coloniser of human skin and mucous membranes, is increasingly being recognised as an emerging pathogen. we present a case of a 69-year-old woman with empyema and osteomyelitis caused by c. striatum. to the best of our knowledge, this is the first case where these two infections from this bacterium were identified together in the same individual.201626944378
[acute exacerbation of bronchiectasis: imputability of a corynebacterium striatum infection?]. 201626795081
multidrug-resistant corynebacterium striatum associated with increased use of parenteral antimicrobial drugs. 201627767926
an unusual case of corynebacterium striatum endocarditis in a patient with congenital lymphedema and rheumatic heart disease.corynebacterium striatum (c. striatum) is a ubiquitous saprophyte with a potential to cause bacteremia. we report the first case of c. striatum endocarditis in a patient with congenital lymphedema and rheumatic heart disease.201627751312
rare case of corynebacterium striatum septic arthritis.corynebacterium species are aerobic, gram-positive bacilli that are commensal organisms of skin and mucosal membranes. although its pathogenicity is well established, corynebacterium striatum is frequently isolated in cultures and generally regarded as a contaminant. rarely, this bacterium causes septic arthritis. we present a case of right shoulder joint septic arthritis due to c. striatum in a lung-transplant recipient with end-stage renal disease. a brief review of the literature regarding c. ...201627664229
staphylococcus aureus shifts toward commensalism in response to corynebacterium species.staphylococcus aureus-human interactions result in a continuum of outcomes from commensalism to pathogenesis. s. aureus is a clinically important pathogen that asymptomatically colonizes ~25% of humans as a member of the nostril and skin microbiota, where it resides with other bacteria including commensal corynebacterium species. commensal corynebacterium spp. are also positively correlated with s. aureus in chronic polymicrobial diabetic foot infections, distinct from acute monomicrobial s. aur ...201627582729
[corynebacterium striatum meningitis]. 201627461372
extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines.chronic venous ulcer (cvu) represents a dreaded complication of chronic venous disease (cvd). the onset of infection may further delay the already precarious healing process in such lesions. some evidences have shown that matrix metalloproteinases (mmps) are involved and play a central role in both cvus and infectious diseases. two groups of patients were enrolled to evaluate the expression of mmps in infected ulcers and the levels of inflammatory cytokines as well as their prevalence. group i c ...201624618232
diphtheroids-important nosocomial pathogens.diphtheroids are defined as aerobic, non-sporulating, pleomorphic gram-positive bacilli which are more uniformly stained than corynebacterium diphtheriae, lack the metachromatic granules and are arranged in a palisade manner. they are usually commensals of the skin and mucous membranes. they differ from c.diphtheriae in biochemical rea-ctions as well as in toxin production. since, they are usually found as commensals on the skin, they are often considered as mere contaminants when isolated from ...201628208859
susceptibility to aminoglycosides and distribution of aph and aac(3)-xi genes among corynebacterium striatum clinical isolates.corynebacterium striatum is an opportunistic pathogen, often multidrug-resistant, which has been associated with serious infections in humans. aminoglycosides are second-line or complementary antibiotics used for the treatment of corynebacterium infections. we investigated the susceptibility to six aminoglycosides and the molecular mechanisms involved in aminoglycoside resistance in a collection of 64 corynebacterium striatum isolated in our laboratory during the period 2005-2009. antimicrobial ...201627936101
native valve endocarditis due to corynebacterium striatum confirmed by 16s ribosomal rna sequencing: a case report and literature review.corynebacterium species are non-fermentous gram-positive bacilli that are normal flora of human skin and mucous membranes and are commonly isolated in clinical specimens. non-diphtheriae corynebacterium are regarded as contaminants when found in blood culture. currently, corynebacterium striatum is considered one of the emerging nosocomial agents implicated in endocarditis and serious infections. we report a case of native-valve infective endocarditis caused by c. striatum, which was misidentifi ...201627659439
clinical and bacteriological analyses of bacteremia due to corynebacterium striatum.corynebacterium striatum was recently recognized as a potential pathogen of various infectious diseases. however, the clinical entity of this microorganism has not been clearly identified. therefore, we analyzed c. striatum isolates from blood culture and explored their clinical determinants.201627654073
rapid transmission of multidrug-resistant corynebacterium striatum among susceptible patients in a tertiary hospital in china.with increasing reports about corynebacterium striatum, its potential pathogenicity and clinical significance are drawing more attention in recent years.201628036309
[chronic osteomyelitis due to corynebacterium striatum in a female adolescent].a case of a girl with chronic posttraumatic osteomyelitis of the right tibia with microbiological isolation of bacillus spp. by conventional methods and confirmation by mass spectrometry maldi-tof (matrix-assisted laser desorption/ionization time-of-flight mass) of corynebacterium striatum is presented. diagnostic methods, clinical manifestations, and resistance pattern of these infections are described.201628146197
an extremely rare case of tubo-ovarian abscesses involving corynebacterium striatum as causative agent.we present an extremely rare case of tubo-ovarian abscesses involving corynebacterium striatum (c. striatum) as causative agent in a 53-year-old woman.201627686475
[etiology of ventilator-associated pneumonia at the cardiovascular surgery clinic of iaşi].we want to assess the etiology of ventilator-associated pneumonia (vap) and emergence of resistant phenotypes for greater efficiency of the first-line antimicrobial treatment post-cardiac surgery. the study focuses on patients with vap post-cardiac surgery at the institute of cardiovascular surgery between april 2nd 2002 and august 27th 2008, divided in two groups, before and after june 14th, 2005.201623077867
clinical significance of commensal gram-positive rods routinely isolated from patient samples.commensal bacteria from the skin and mucosal surfaces are routinely isolated from patient samples and considered contaminants. the majority of these isolates are catalase-positive gram-positive rods from multiple genera routinely classified as diphtheroids. these organisms can be seen upon gram staining of clinical specimens or can be isolated as the predominant or pure species in culture, raising a priori suspicion of a possible involvement in infection. with the development and adoption of mat ...201627629905
infective endocarditis risk after percutaneous pulmonary valve implantation with the melody and sapien valves.this study compared the risk of infective endocarditis (ie) after percutaneous pulmonary valve implantation (ppvi) with the sapien and melody valves.201728279319
corynebacterium striatum bacteremia associated with a catheter-related blood stream infection.a 49-year-old woman visited our emergency department because of exertional dyspnea due to severe left ventricular functional failure. it progressed to disseminated intravascular coagulation and disturbance of consciousness on day 67 of admission. gram-positive bacilli were detected from two different blood culture samples on day 67 of admission. an api-coryne test and sequencing (1~615 bp) of the 16s rrna gene were performed, and the strain was identified as corynebacterium striatum. the bacteri ...201728197349
clinical characteristics and predictive factors for mortality in coryneform bacteria bloodstream infection in hematological patients.we examined the clinical characteristics and predictive factors for mortality in coryneform bacteria bloodstream infection in hematological patients.201728011352
septic arthritis in a native knee due to corynebacterium striatum.we describe a case of septic arthritis in a native knee due to corynebacterium striatum, gram-positive bacilli that are usually commensal organisms of skin and mucosal membranes, but are seldom implicated in native septic arthritis. an 84-year-old man with corynebacterium striatum septic arthritis of his native left knee and no response to conventional antibiotic therapy. thus, the patient was allowed to take dalbavancin for compassionate use, with an excellent clinical outcome. this case emphas ...201728283311
a case of fatal sepsis due to multidrug-resistant corynebacterium striatum.although non-diphtheria corynebacteria have traditionally been regarded as avirulent members of human bacterial flora, their pathogenic potential is increasingly recognized in our time. reasons for this include the prolonged survival of severely ill and immunocompromised patients, the development of more invasive diagnostic and therapeutic procedures and the sub-optimal use of antibiotics that disrupts normal microbial balance and favors superinfections.201727895446
the left atrial bacterial vegetative mass due to corynebacterium striatum as a presentation of myxoma: a case report.corynebacterium striatum is a member of the non-diphtherial corynebacteria, which are ubiquitous in nature and generally colonize the skin and mucous membranes of humans. rarely, it causes infective endocarditis (ie). we report a case of rare left atrial bacterial vegetative mass due to c. striatum masquerading as a myxoma identified through a tortuous diagnostic process, and present a brief review of the relevant literature.201728549450
when good bugs go bad: epidemiology and antimicrobial resistance profiles of corynebacterium striatum, an emerging multidrug resistant, opportunistic pathogen.infections with corynebacterium striatum have been described in the literature over the last two decades, with the majority being bacteremia, central line infections, and occasionally endocarditis. in recent years, the frequency of c. striatum infections appears to be increasing; a likely factor contributing to this is the increased ease and accuracy of the identification of corynebacterium spp., including c. striatum, from clinical cultures. the objective of this study was to retrospectively ch ...201728848008
bacterial contaminants from frozen puff pastry production process and their growth inhibition by antimicrobial substances from lactic acid bacteria.seventy-five bacterial contaminants which still persisted to cleaning system from three puff pastry production lines (dough forming, layer and filling forming, and shock freezing) were identified using 16s rdna as seven genera of bacillus, corynebacterium, dermacoccus, enterobacter, klebsiella, pseudomonas, and staphylococcus with detection frequencies of 24.00, 2.66, 1.33, 37.33, 1.33, 2.66, and 30.66, respectively. seventeen species were discovered while only 11 species bacillus cereus, b. sub ...201728572930
cutaneous corynebacterium infection presenting with disseminated skin nodules and ulceration.in the context of the european migrant crisis, more and more cases of cutaneous diphtheria are seen. a typical presentation includes painful cutaneous ulcerations with grayish-whitish pseudomembranes. here we present 2 male eritrean patients suffering from cutaneous nontoxigenic corynebacterium diphtheriae (patient 1) and corynebacterium striatum (patient 2) infection.201728611629
characteristics of multidrug-resistant corynebacterium spp. isolated from blood cultures of hospitalized patients in japan.corynebacterium is a genus consisting of gram-positive, rod-shaped bacteria, that is wildly distributed in nature. we report the epidemiological characterization of corynebacterium spp. isolated from blood specimens at the kurume university hospital, between june 2008 and november 2011. twenty-two strains that were likely corynebacterium spp. were isolated from 22 hospitalized patients, of which 12 (54.5%) were identified as corynebacterium striatum. minimum inhibitory concentration tests were p ...201727357981
development of high-grade daptomycin resistance in a patient being treated for corynebacterium striatum infection. 201728483949
occurrence of corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a tunisian hospital.corynebacterium striatum is a nosocomial opportunistic pathogen increasingly associated with a wide range of human infections and is often resistant to several antibiotics. we investigated the susceptibility of 63 c. striatum isolated at the farhat-hached hospital, sousse (tunisia), during the period 2011-2014, to a panel of 16 compounds belonging to the main clinically relevant classes of antimicrobial agents. all strains were susceptible to vancomycin, linezolid, and daptomycin. amikacin and g ...201728848236
multiple pulmonary nodules caused by corynebacterium striatum in an immunocompetent patient.nondiphtherial corynebacteria are ubiquitous in nature and commonly colonize the skin and mucous membranes of humans, however they rarely account for clinical infection. we present the first reported case of multiple pulmonary nodules caused by corynebacterium striatum. the infection occurred in a 72-year-old immunocompetent female, and the diagnosis was obtained by gram's stain and culture of lung biopsy. c. striatum should be recognized as a potential pathogen in both immunocompromised and nor ...201724553616
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