Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| antifungal activity against plant pathogenic fungi of chaetoviridins isolated from chaetomium globosum. | the chaetomium globosum strain f0142, which was isolated from barnyard grass, showed potent disease control efficacy against rice blast (magnaporthe grisea) and wheat leaf rust (puccinia recondita). two antifungal substances were purified from broth from this organism and identified as chaetoviridins a and b. chaetoviridin a exhibited higher antifungal activity than chaetoviridin b against plant pathogenic fungi both in vitro and in vivo. treatment with chaetoviridin a at 62.5 microg/ml suppress ... | 2005 | 16209910 |
| [cloning and characterization of glyceraldehyde-3-phosphate dehydrogenase gene from chaetomium globosum]. | the amino acid sequence of glyceraldehyde 3-phosphate dehydrogenase (gapdh) gene from neurospora crassa (xp-327967) and colletotrichum lindemuthianu (p35143) were subjected to local tblastn searching against the ests local datebase of chaetomium globosum. the full length cdna sequence of 1240bp encoding gapdh gene with an open reading frame of 1014bp and encoding 337 amino acids was obtained. the protein molecular weight was 36.1kd. the dna sequence of gapdh gene was obtained through pcr amplifi ... | 2005 | 16496697 |
| development of aflp-derived, functionally specific markers for environmental persistence studies of fungal strains. | the ability to rapidly identify and quantify a microbial strain in a complex environmental sample has widespread applications in ecology, epidemiology, and industry. in this study, we describe a rapid method to obtain functionally specific genetic markers that can be used in conjunction with standard or real-time polymerase chain reaction (pcr) to determine the abundance of target fungal strains in selected environmental samples. the method involves sequencing of randomly cloned aflp (amplified ... | 2006 | 16699570 |
| chemokine receptor ccr-5 inhibitors produced by chaetomium globosum. | two novel chemokine receptor ccr-5 inhibitors, sch 210971 (1) and sch 210972 (2), were isolated from the fungal fermentation broth of chaetomium globosum by normal- and reversed-phase hplc purifications. the structure determination of 1 and 2 was accomplished on the basis of uv, ms, and nmr spectral data analyses including cosy, noesy, hmqc, and hmbc experiments. the structure and relative configuration of 2 were determined unequivocally by x-ray crystallographic analysis. the major component 2 ... | 2006 | 16872138 |
| a new dihydroxanthenone from a plant-associated strain of the fungus chaetomium globosum demonstrates anticancer activity. | bioassay-guided fractionation of a cytotoxic etoac extract of the fungal strain, chaetomium globosum, inhabiting the rhizosphere of the christmas cactus, opuntia leptocaulis, of the sonoran desert afforded a new dihydroxanthenone, globosuxanthone a (1), a new tetrahydroxanthenone, globosuxanthone b (2), two new xanthones, globosuxanthone c (3) and d (4), 2-hydroxyvertixanthone (5), and two known anthraquinones (6 and 7). the structures of the new compounds 1-4 were elucidated by nmr and ms techn ... | 2006 | 16904330 |
| a case of subcutaneous phaeohyphomycosis caused by chaetomium globosum and the sequences analysis of c. globosum. | a 14-year-old boy developed painful erythema and necrosis on his face with petechia on his upper extremities. microscopically, necrotic tissue treated with potassium hydroxide showed branched, dematiaceous, septate hyphae. chaetomium globosum was isolated repeatedly from the necrotic tissues. morphology and thermotolerance test of the pathogen were also studied. the internal transcribed spacer region in rrna gene was amplified and sequenced. the sequence of this patient matched well with that of ... | 2006 | 16966171 |
| chaetocochins a-c, epipolythiodioxopiperazines from chaetomium cochliodes. | three new epipolythiodioxopiperazines, chaetocochins a (1), b (2), and c (3), along with dethio-tetra (methylthio) chetomin (4) and chetomin (5), were isolated from the ethyl acetate extract of the solid-state fermented rice culture of the fungus chaetomium cochliodes. their structures were elucidated on the basis of spectroscopic analysis. compounds 1, 3, and 4 exhibited significant cytotoxicity in vitro against cancer cell lines bre-04, lu-04, and n-04. | 2006 | 16989540 |
| chaetopyranin, a benzaldehyde derivative, and other related metabolites from chaetomium globosum, an endophytic fungus derived from the marine red alga polysiphonia urceolata. | cultivation of the endophytic fungus chaetomium globosum, which was isolated from the inner tissue of the marine red alga polysiphonia urceolata, resulted in the isolation of chaetopyranin (1), a new benzaldehyde secondary metabolite. ten known compounds were also isolated, including two benzaldehyde congeners, 2-(2',3-epoxy-1',3'-heptadienyl)-6-hydroxy-5-(3-methyl-2-butenyl)benzaldehyde (2) and isotetrahydroauroglaucin (3), two anthraquinone derivatives, erythroglaucin (4) and parietin (5), fiv ... | 2006 | 17125234 |
| in-vessel composting of household wastes. | the process of composting has been studied using five different types of reactors, each simulating a different condition for the formation of compost; one of which was designed as a dynamic complete-mix type household compost reactor. a lab-scale study was conducted first using the compost accelerators culture (trichoderma viridae, trichoderma harzianum, trichorus spirallis, aspergillus sp., paecilomyces fusisporus, chaetomium globosum) grown on jowar (sorghum vulgare) grains as the inoculum mix ... | 2006 | 16153815 |
| chaetoglobosin u, a cytochalasan alkaloid from endophytic chaetomium globosum ifb-e019. | a new cytotoxic cytochalasan-based alkaloid named chaetoglobosin u (1), along with four known analogues, chaetoglobosins c (2), f (3), and e (5) and penochalasin a (4), has been characterized from the etoac extract of a solid culture of chaetomium globosum ifb-e019, an endophytic fungus residing inside the stem of healthy imperata cylindrica. the structure of chaetoglobosin u was determined through correlative analyses of its uv, ir, cd, ms, and 1d ((1)h and(13)c nmr and dept) and 2d nmr (cosy, ... | 2006 | 16499339 |
| characterization of fungi from hypersaline environments of solar salterns using morphological and molecular techniques. | the cabo rojo solar salterns located on the southwest coast of puerto rico are composed of two main ecosystems (i.e., salt ponds and microbial mats). even though these locations are characterized by high solar radiation (mean light intensity of 39 mol photons m-2d-1) they harbour a diverse microscopic life. we used morphological and molecular techniques to identify a series of halotolerant fungi. a total of 183 isolates and 36 species were cultured in this study. from the water from the salt pon ... | 2006 | 16904880 |
| association between sensitization to aureobasidium pullulans (pullularia sp) and severity of asthma. | recent data indicate that fungi may contribute to increased severity of asthma. | 2007 | 17304882 |
| activation of prothrombin by two subtilisin-like serine proteases from acremonium sp. | two novel subtilisin-like serine proteases (as-e1 and -e2) that activate prothrombin have been identified in a culture of the fungus acremonium sp. the enzymes were purified through repeated hydrophobic interaction chromatography. the n-terminal sequences of as-e1 (34.4 kda) and as-e2 (32 kda) showed high similarity to the internal sequences of two distinct subtilisin-like hypothetical proteins from chaetomium globosum. both enzymes proteolytically activated prothrombin to meizothrombin(desf1)-l ... | 2007 | 17482570 |
| sch 213766, a novel chemokine receptor ccr-5 inhibitor from chaetomium globosum. | a novel fungal secondary metabolite, sch 213766 was isolated from the fungal fermentation broth of chaetomium globosum as the chemokine receptor ccr-5 inhibitor and shown to be the methyl ester of the previously described tetramic acid sch 210972 on the basis of uv, ms and nmr spectral data analyses. sch213766 exhibited an ic(50) value of 8.6 mum in the ccr-5 receptor in vitro binding assay. | 2007 | 17827664 |
| effect of selected natural dyes in reduction on colour changes of egyptian linen textiles by fungi. | linen is the most historical egyptian textile fibre liable to fungal deterioration. fungal deterioration of dyed linen textiles may appear as undesirable different stains. in order to success in removing of fungal stains from biodeteriorated historical egyptian dyed linen textiles, it is necessary to understand the nature and causes of these stains, hence their subsequent removal. so this paper aims to investigate the effect of fungi on dyed linen textiles. in this study linen textile samples we ... | 2007 | 17867537 |
| [adaptation of chaetomium globosum 3250 kunze ex fr. to the rhizosphere of spring wheat and its ability to colonize the root system]. | the ability of the natural strain of marsupial fungus chaetomium globosum 3250 to adapt to the rhizosphere soil of the spring wheat, and to colonize its root system has been studied in the laboratory and field experiments. it is established that c. globosum 3250 adapts to the rhyzosphere soil of culture during vegetative period, actively colonizes the culture root system, forcing the agents of roots rots out of it. a preparation of khetomyk is created on the basis of the above culture for the im ... | 2007 | 17977453 |
| first spanish case of onychomycosis caused by chaetomium globosum. | members of the fungal genus chaetomium usually colonize cellulose-containing plant remains but on rare occasions may cause opportunistic mycoses and cutaneous infection in otherwise healthy individuals. to our knowledge, there have been only five credible descriptions of onychomycosis caused by members of this genus and only two of these contained information on therapy. we describe the first case of chaetomium globosum onychomycosis recorded in spain. the etiologic significance of the fungus wa ... | 2007 | 17464849 |
| electrospray tandem mass spectrometry of epipolythiodioxopiperazines. | low-energy collision-induced electrospray ionization tandem mass spectrometry esi-cid-ms/ms (in the positive ion mode) was used for the structural characterization of a series of five representative epioplythiodioxopipreazines: dethiotetra(methylthio)chemotin, chaetocochins a, b and c, and chemotin isolated from the fungus chaetomium cochliodes. the fragmentation pathways were elucidated by esi-it-ms(n). the elemental compositions of most of the product ions were confirmed by low-energy esi-cid- ... | 2007 | 17492721 |
| growth and mycotoxin production by chaetomium globosum. | chaetomium globosum, the most common species within this genus, produces chaetoglobosins a and c when cultured on building material. relatively low levels of these compounds have been shown to be lethal to various tissue culture cell lines. this study had two major objectives: (1) to determine the frequency at which chaetomium species are isolated in water-damaged buildings and (2) to examine the production of chaetoglobosins a and c in isolates of c. globosum obtained from different buildings. ... | 2007 | 17551849 |
| quantitative pcr analysis of molds in the dust from homes of asthmatic children in north carolina. | the vacuum bag (vb) dust from the homes of 19 asthmatic children in north carolina (nc) was analyzed by mold specific quantitative pcr. these results were compared to the analysis of the vb dust from 176 homes in the hud, american healthy home survey of homes in the us. the environmental relative moldiness index (ermi) was calculated for each of the homes. the mean and standard deviation (sd) of the ermi values in the homes of the nc asthmatic children was 16.4 (6.77), compared to the hud survey ... | 2007 | 17671663 |
| a heat shock protein gene (hsp22.4) from chaetomium globosum confers heat and na2co3 tolerance to yeast. | a small heat shock protein gene (hsp22.4) was cloned from chaetomium globosum using rapid amplification of cdna ends (race). the 986-bp full-length hsp22.4 cdna contains a 609-bp open reading frame encoding a 202-amino-acid protein with an estimated molecular mass of 22.4 kda. the hsp22.4 gene was amplified using specific primers in the 5' and 3' untranslated regions of the hsp22.4 cdna. the temporal expression of hsp22.4 was measured in c. globosum by real-time reverse transcriptase-polymerase ... | 2007 | 17940762 |
| variation of soil mycoflora in decomposition of rice stubble from rice-wheat cropping system. | the colonization pattern and extent of decay produced in paddy stubble by soil inhabiting mycoflora were done by using nylon net bag technique. among the three methods used for isolation of fungi, dilution plate technique recorded the highest number of fungi followed by damp chamber and direct observation method. nutrient availability and climatic conditions (temperature, humidity and rainfall) influenced the occurrence and colonization pattern of fungi. maximum fungal population was recorded in ... | 2007 | 24015096 |
| ecological and physiological studies on soil fungi at western region, libya. | sixty three species and 5 varieties belonging to 30 fungal genera were collected from 75 soil samples. cultivated (29 genera and 58 species + 5 var.), desert (22 and 35 + 2 var.) and saline soil (21 and 41 + 1 var.) fungi were recovered on glucose-, cellulose- and 50% sucrose-czapek's agar at 28℃. the most common genera were alternaria, aspergillus, emericella, fusarium, mycosphaerella, nectria and penicillium. the most prevalent species from the three types of soils on the three types of media ... | 2008 | 23997599 |
| fungal communities in herbaceous medicinal plants from the malnad region, southern india. | fungal communities were isolated from surface sterilized leaf segments of nine ethnopharmaceutically important medicinal herbs collected from the bhadra river project area, the malnad region, southern india. a total of 2159 isolates belonging to 55 different fungal species were isolated from 3600 leaf segments collected during the wet and dry seasons. chaetomium globosum (7.3%), aureobasidium pullulans (6.1%), cladosporium cladosporioides (3.9%), curvularia lunata (1.9%), nigrospora oryzae (1.7% ... | 2008 | 21558683 |
| growth and mycotoxin production by chaetomium globosum is favored in a neutral ph. | chaetomium globosum is frequently isolated in water-damaged buildings and produces two mycotoxins called chaetoglobosins a and c when cultured on building material. in this study, the influence of ambient ph on the growth of c. globosum was examined on an artificial medium. this fungus was capable of growth on potato dextrose agar ranging in ph from 4.3 to 9.4 with optimal growth and chaetoglobosin c production occurring at a neutral ph. in addition, our results show that sporulation is favored ... | 2008 | 19330080 |
| three isolations of chaetomium globosum from erythematous epilation of canine skin. | chaetomium globosum is commonly found in natural environments worldwide and is known to be a causative agent for emerging fungal infections. the present study describes a case of erythematous epilation of a dog caused by c. globosum. a mixed-breed young dog, a 4-months-old male, weighing 7.25 kg, showed depilation, scales, and dermatitis with slightly itchiness on his skin. the main symptom was an erythematous epilation on the left subocular skin 7.5 cm in diameter, accompanied by elephantiasis- ... | 2008 | 18608918 |
| chaetoglobins a and b, two unusual alkaloids from endophytic chaetomium globosum culture. | chaetoglobins a (1) and b (2), two azaphilone alkaloid dimers with an unprecedented skeleton, were characterized from an endophytic fungus chaetomium globosum with the former ascertained to be a significant cytotoxin valuable for anti-tumor drug discovery. | 2008 | 19030558 |
| analysis of epipolythiodioxopiperazines in fungus chaetomium cochliodes using hplc-esi-ms/ms/ms. | a series of epipolythiodioxopiperazines in the fungus chaetomium cochliodes was investigated using reversed-phase liquid chromatography with diode array detection and electrospray quadrupole time-of-flight-type tandem mass spectrometry in the positive ion mode. the fragmentation of protonated molecular ions including low-abundance parent ions, [m+h]+ for five known epipolythiodioxopiperazines, dethiotetra(methylthio)chetomin, chaetocochins a-c, and chetomin, was carried out using low-energy coll ... | 2008 | 18052340 |
| evidence for horizontal transfer of a secondary metabolite gene cluster between fungi. | filamentous fungi synthesize many secondary metabolites and are rich in genes encoding proteins involved in their biosynthesis. genes from the same pathway are often clustered and co-expressed in particular conditions. such secondary metabolism gene clusters evolve rapidly through multiple rearrangements, duplications and losses. it has long been suspected that clusters can be transferred horizontally between species, but few concrete examples have been described so far. | 2008 | 18218086 |
| prevalence of allergic sensitization to indoor fungi in west virginia. | exposure to indoor fungi is of growing concern in residential and occupational environments in the united states. the purpose of this study was to determine the prevalence of sensitization to common indoor fungal species in an atopic population. we evaluated 102 patients (73 female and 29 male patients) for immunoglobulin e (ige) reactivity to a panel of skin-prick test (spt) reagents used for routine allergy testing. patients also were tested for six additional fungi that are common indoor cont ... | 2008 | 18302835 |
| heat stability of chaetoglobosins a and c. | chaetomium globosum is commonly found in water-damaged buildings and produces the mycotoxins chaetoglobosin a and chaetoglobosin c (ch-a and ch-c, respectively). while attempting to purify ch-a and ch-c, we observed that these mycotoxins were broken down after heating. the objective of this study was to determine the temperature and the amount of time necessary to break down ch-a and ch-c. we demonstrated that the amounts of ch-a were significantly reduced when exposed to 75 degrees c for 24 h a ... | 2008 | 18449228 |
| cloning and characterization of a novel chitinase gene (chi46) from chaetomium globosum and identification of its biological activity. | chitinases play a major role in the defensive strategies of plants against fungal pathogens. in the current study, the gene for a 46-kda endochitinase (chi46) was cloned from chaetomium globosum, an important biocontrol fungus. the corresponding complementary deoxyribonucleic acid sequence was 1,350 bp in length, encoding 449 amino acid residues. the temporal expression of chi46, in response to the treatments of cell walls of six pathogens and confrontation against two fungal pathogens, was meas ... | 2008 | 18563407 |
| differential sensitivity of fungi to lithium chloride in culture media. | forty species of fungi, representing a range of ecological and taxonomic groups, were tested for their ability to grow on agar media amended with lithium chloride (licl) at 1.5, 3 and 6 g l(-1). species of trichoderma varied considerably in their sensitivity to licl; at one week on 6 g l(-1) licl medium, the growth of seven species of trichoderma was considerably inhibited; however, by three weeks at this level, four of the species tested were able to attain > or =30% of control growth. of the s ... | 2008 | 18495451 |
| chaetomugilins, new selectively cytotoxic metabolites, produced by a marine fish-derived chaetomium species. | chaetomugilins a-f have been isolated from a strain of chaetomium globosum originally isolated from the marine fish mugil cephalus, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses, including 1d and 2d nmr techniques, some chemical transformations and an x-ray analysis. these compounds exhibited significant growth inhibition against cultured p388 cells and hl-60 cells. in addition, chaetomugilins a, c and f showed selective cytotoxic activities agai ... | 2008 | 19168975 |
| study of codon bias perspective of fungal xylanase gene by multivariate analysis. | fungal xylanases has important applications in food, baking, pulp and paper industries in addition to various other industries. xylanases are produced extensively by both bacterial and fungal sources and has tremendous potential of being active at extremes of temperature and ph. in the present study an effort has been made to explore the codon bias perspective of this potential enzyme using bioinformatics tools. multivariate analysis has been used as a tool to study codon bias perspectives of xy ... | 2009 | 19759864 |
| cytotoxic activities of endophytic fungi isolated from the endangered, chinese endemic species dysosma pleiantha. | eleven strains of endophytic fungi which habitat in an endangered, chinese endemic medicinal plant, dysosma pleiantha (hance) woodson, were isolated and tested for their cytotoxic activity using the brine shrimp lethality bioassay. six isolates were found to exhibit some cytotoxic activity. extracts of f1273, f1276, and f1280, which were identified as trichoderma citrinoviride, chaetomium globosum and ascomycete sp., in particular, showed most potent activity with lc50 values of 4.86, 7.71, and ... | 2009 | 19791503 |
| study on the diversity of endophytic communities from rice (oryza sativa l.) and their antagonistic activities in vitro. | endophytic populations were isolated from 2400 segments of oryza sativa collected from bhadra river project area, southern india during december 2005 (winter) and april 2006 (summer). overall colonization rates from surface sterilized tissues were 40.3% in roots and 25.83% in leaves during winter season, 20.15% in roots and 8.66% in leaves during summer season. nineteen different fungal taxa, a streptomyces sp. and bacterial species were isolated. streptomyces sp., chaetomium globosum, penicilli ... | 2009 | 17433644 |
| polyhydroxylated steroids from an endophytic fungus, chaetomium globosum zy-22 isolated from ginkgo biloba. | a novel polyhydroxylated c(29)-sterol, 25xi-methyl-22-homo-5alpha-cholest-7,22-diene-3beta,6beta,9alpha-triol, designated globosterol (1), together with one known tetrahydroxylated ergosterol (22e, 24r)-ergosta-7,22-diene-3beta,5alpha,6beta,9alpha-tetraol (2) has been isolated from the cultures of an endophytic fungus, chaetomium globosum zy-22 originated from the plant ginkgo biloba. the structures and relative configurations of 1 and 2 were established on the basis of extensive spectroscopic a ... | 2009 | 19427327 |
| bioactive metabolites produced by chaetomium globosum, an endophytic fungus isolated from ginkgo biloba. | a novel cytotoxic chlorinated azaphilone derivative named chaetomugilin d (1), together with three known metabolites, chaetomugilin a (2), chaetoglobosins a (3) and c (4), has been isolated by a bioassay-guided fractionation from the etoac extract of the cultures of chaetomium globosum, an endophytic fungus found in the leaves of ginkgo biloba. structure of 1 was established by analyses of spectroscopic methods, including 2d-nmr experiments (cosy, noesy, hmqc, and hmbc). compounds 1-4 displayed ... | 2009 | 19246197 |
| purification, characterization and mass spectrometric sequencing of a thermophilic glucuronoyl esterase from sporotrichum thermophile. | the cellulolytic system of the thermophilic fungus sporotrichum thermophile contains a recently discovered esterase that may hydrolyze the ester linkage between the 4-o-methyl-d-glucuronic acid of glucuronoxylan and lignin alcohols. the glucuronoyl esterase named stge1 was purified to homogeneity with a molecular mass of m(r) 58 kda and pi 6.7. the enzyme activity was optimal at ph 6.0 and 60 degrees c. the esterase displayed a narrow ph range stability at ph 8.0 and retained 50% of its activity ... | 2009 | 19459957 |
| absolute stereostructures of chaetomugilins g and h produced by a marine-fish-derived chaetomium species. | chaetomugilins g and h were isolated from a strain of chaetomium globosum that was originally isolated from the marine fish, mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1d and 2d nmr techniques, and chemical transformation. in addition, the absolute configuration of chaetoviridin c was established by derivatization from chaetomugilin a. these compounds exhibited a growth inhibitory activity against cultured p388, hl-60, l1 ... | 2009 | 19461670 |
| new azaphilones, seco-chaetomugilins a and d, produced by a marine-fish-derived chaetomium globosum. | seco-chaetomugilins a and d were isolated from a strain of chaetomium globosum that was originally isolated from the marine fish mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1d and 2d nmr techniques, along with the chemical transformation from known chaetomugilins a and d. seco-chaetomugilin d exhibited growth inhibitory activity against cultured p388, hl-60, l1210, and kb cells. | 2009 | 19597583 |
| cytoglobosins a-g, cytochalasans from a marine-derived endophytic fungus, chaetomium globosum qen-14. | cytoglobosins a-g (1-7), seven new cytochalasan derivatives, along with two structurally related known compounds, isochaetoglobosin d (8) and chaetoglobosin f(ex) (9), were isolated and identified from the cultures of chaetomium globosum qen-14, an endophytic fungus derived from the marine green alga ulva pertusa. the structures of the new natural products as well as their relative configurations were elucidated on the basis of 1d and 2d nmr spectra (cosy, hsqc, hmbc, and noesy) and hresims data ... | 2010 | 20225834 |
| cleavage of resveratrol in fungi: characterization of the enzyme rco1 from ustilago maydis. | ustilago maydis, the causative agent of corn smut disease, contains two genes encoding members of the carotenoid cleavage oxygenase family, a group of enzymes that cleave double bonds in different substrates. one of them, cco1, was formerly identified as a β-carotene cleaving enzyme. here we elucidate the function of the protein encoded by the second gene, termed here as ustilago maydis resveratrol cleavage oxygenase 1 (um rco1). in vitro incubations of heterologously expressed and purified um r ... | 2010 | 21073977 |
| precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action. | precursor-fed cultivation of endophytic chaetomium globosum 1c51 afforded nine novel "unnatural" halogenated chaetoglobosins including those with more preferable immunosuppressive activity. | 2010 | 21152613 |
| indoor air mycoflora of residential dwellings in jos metropolis. | the quality of air in the environment where one lives or works can have potential effects on human health. there are strong indications that in many parts of the world, our homes, schools and workplaces are heavily contaminated with air-borne molds and other biological contaminants. | 2010 | 21326971 |
| in vitro antagonism of cotton seedlings fungi and characterization of chitinase isozyme activities in trichoderma harzianum. | the antagonistic fungus trichoderma harzianum is widely recognized as a potential biocontrol agent against several soil-borne plant pathogens. t. harzinum is rich source of chitinoltic enzymes. in vitro screening of 5 isolates of t. harzinum, one isolate of chaetomium globosum and one isolate of conetherium mentance, revealed that all of them had reduced growth area of macrophomina phaseolina, fusarium solani and rhizoctonia solani on pda medium, significantly. the inhibition percentage ranged f ... | 2010 | 23961072 |
| cytotoxic chaetoglobosins from the endophyte chaetomium globosum. | two new alkaloids chaetoglobosins v (1) and w (2), together with the six known congeners 3-8, were isolated through bioassay-guided fractionations from the etoac extract of a solid culture of chaetomium globosum ifb-e041. the structures were elucidated by spectroscopic methods including mainly 1d and 2d nmr techniques. chaetoglobosin w (2) was unique in its possession of an oxolane ring formed via an oxygen bridge between c-3 and c-6. the isolated fungal metabolites exhibited moderate cytotoxic ... | 2010 | 20486076 |
| lc-ms-ms determination of ibuprofen, 2-hydroxyibuprofen enantiomers, and carboxyibuprofen stereoisomers for application in biotransformation studies employing endophytic fungi. | the purpose of this study was the development and validation of an lc-ms-ms method for simultaneous analysis of ibuprofen (ibp), 2-hydroxyibuprofen (2-oh-ibp) enantiomers, and carboxyibuprofen (cooh-ibp) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug ibp into its metabolites. resolution of ibp and the stereoisomers of its main metabolites was achieved by use of a chiralpak as-h column (150 × 4.6 mm, 5 μm particle size), ... | 2010 | 21079932 |
| [the effect of different endophytic fungi on chrysanthemum morifolium output and quality]. | to enhance the flowers yield of chrysanthemum morifolium by endophytic fungi. | 2010 | 20518295 |
| antimicrobial/antimold polymer-grafted starches for recycled cellulose fibers. | in this work, an antimicrobial guanidine polymer (phgh) was grafted onto starch as a carrier to form branched or grafted chains along the starch backbone. this grafting improved the antimicrobial properties and the adsorption of the starch on recycled cellulose fibers. similar work was also conducted on bleached sulfite fibers for comparison. the results showed that the starch, grafted with 12 wt% phgh, adsorbed more on recycled fibers than on sulfite fibers. by applying the antimicrobial-modifi ... | 2010 | 20534190 |
| a comparative study of activity and apparent inhibition of fungal β-glucosidases. | β-glucosidases (bgs) from aspergillus fumigates, aspergillus niger, aspergillus oryzae, chaetomium globosum, emericella nidulans, magnaporthe grisea, neurospora crassa, and penicillium brasilianum were purified to homogeneity, and analyzed by isothermal titration calorimetry with respect to their hydrolytic activity and its sensitivity to glucose (product) using cellobiose as substrate. global non-linear regression of several reactions, with or without added glucose, to a product inhibition equa ... | 2010 | 20677177 |
| onychomycosis due to ascomycete chaetomium globosum: a case report. | 2010 | 20699530 | |
| non-dermatophyte moulds as skin and nail foot mycosis agents: phoma herbarum, chaetomium globosum and microascus cinereus. | the increased prevalence of dermatomycoses along with the wide range of organisms now recognized as potential pathogens needs accurate laboratory isolation and identification of the aetiological agents. in this report three cases of foot dermatomycoses due to filamentous fungi commonly present in the environment with ubiquitous distribution are described in immunocompetent subjects. skin and nail samples were collected, suspended in 20% koh solution, examined under a light microscope and culture ... | 2010 | 20943144 |
| the human ku autoantigen shares amino acid sequence homology with fungal, but not bacterial and viral, proteins. | context: molecular mimicry between autoantigens and microbial antigens is a possible triggering mechanism of autoimmunity. human ku is a dna-associated autoantigen targeted by autoantibodies in patients with systemic lupus erythematosus and related disorders; available data are consistent with a role of molecular mimicry in the pathogenesis of anti-ku autoimmunity, but no research exist on this topic. objective: we aimed to define the most probable microbial triggers of anti-ku autoimmunity via ... | 2011 | 20718578 |
| the possible role of fungal contamination in sick building syndrome. | the following is a review of some of the work that we have done since 2007 regarding the importance of molds in the phenomenon of sick building syndrome (sbs). in these studies we first examined mold contamination in air handling units (ahu). our results showed that cladosporium sp. were commonly recovered in ahu as growth sites and free spores. they were found mainly on the blower wheel fan blades, the ductwork, and cooling coil fans. our results showed that the presence of species of molds oth ... | 2011 | 21196335 |
| azaphilones from the endophyte chaetomium globosum. | six new azaphilones, 5'-epichaetoviridin a (7), 4'-epichaetoviridin f (9), 12β-hydroxychaetoviridin c (10), and chaetoviridins g-i (11-13), and six known azaphilones, chaetoviridins a-e (1-5) and 4'-epichaetoviridin a (8), were isolated from the endophytic fungus chaetomium globosum cultivated in pdb medium for 21 days. the structure elucidation and the assignment of the relative configurations of the new natural products were based on detailed nmr and ms spectroscopic analyses. the structure of ... | 2011 | 21548578 |
| [effect of peg stress on plantlets of chrysanthemum morifolium induced by endophytic botrytis sp. (c1) and chaetomium globosum (c4)]. | the effect of the endophytic fungi botrytis sp. (c1) or chaetomium globosum (c4) on the drought resistance of chrysanthemum morifolium was studied. ch. morifolium plantlets were inoculated with c1, c4 and cultured in the pots for 60 days, then the plantlets were stressed by 0%, 10%, 20%, 30%, 40% peg6000 respectively in order to simulate different drought conditions. biomass, the activities of sod, pod, pal, the contents of mda and soluble protein of each group were determined. the results showe ... | 2011 | 21585031 |
| endophytic fungal flora from roots and fruits of an indian neem plant azadirachta indica a. juss., and impact of culture media on their isolation. | azadirachta indica a. juss. (neem), native to india, is well known worldwide for its insecticidal and ethanopharmacological properties. although endophytic microbes are known from this plant as only leaves and stems were the subjects of past reports. now, a variety of procedures and a number of different media were used to isolate the maximum number of endophytic fungi from unripe fruits and roots. a total of 272 isolates of 29 filamentous fungal taxa were isolated at rate of 68.0% from 400 samp ... | 2011 | 23024409 |
| controlling myzus persicae with recombinant endophytic fungi chaetomium globosum expressing pinellia ternata agglutinin: using recombinant endophytic fungi to control aphids. | sap-sucking insect pests have become the major threats to many crops in recent years; however, only a few biopesticides have been developed for controlling those pests. here, we developed a novel pest management strategy, which uses endophytes to express anti-pest plant lectins. | 2011 | 21414115 |
| phaeohyphomycosis and onychomycosis due to chaetomium spp., including the first report of chaetomium brasiliense infection. | chaetomium species have been rarely described as aetiological agents of invasive and dermatomycotic infections in humans. the majority of cases have been reported within the last two decades. treatment failed in most of these cases. in this paper we present two cases in which chaetomium spp. can be clearly identified as an aetiological agent in pathological conditions. in the first report, we describe a new aetiological agent, chaetomium brasiliense, which was implicated in a case of otitis exte ... | 2011 | 21466265 |
| new class azaphilone produced by a marine fish-derived chaetomiumglobosum. the stereochemistry and biological activities. | four new metabolites, chaetomugilins p-r and 11-epi-chaetomugilin i, were isolated from a strain of chaetomium globosum originally obtained from the marine fish mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1d and 2d nmr techniques and various chemical transformations. particularly, the skeleton of chaetomugilin p is different from that of other azaphilones isolated from this fungal strain to date. in addition, these compoun ... | 2011 | 21640594 |
| Chaetoglobosin Fex from the Marine-Derived Endophytic Fungus Inhibits Induction of Inflammatory Mediators via Toll-Like Receptor 4 Signaling in Macrophages. | Chaetoglobosin Fex (Cha Fex), a cytochalasan-based alkaloid, was isolated from marine-derived endophytic fungus Chaetomium globosum QEN-14. The knowledge of its biological function is still limited. We investigated the effects and mechanism of Cha Fex on inflammatory mediators via Toll-like receptor 4 (TLR4) signaling in macrophages. Lipopolysaccharide (LPS), TLR4 ligand, was therefore designed to active TLR4 signaling pathway, and Cha Fex significantly inhibited the LPS-induced production of tu ... | 2011 | 22130243 |
| bioactive metabolites from chaetomium globosum l18, an endophytic fungus in the medicinal plant curcuma wenyujin. | an endophytic fungus, strain l18, isolated from the medicinal plant curcuma wenyujin y.h. chen et c. ling was identified as chaetomium globosum kunze based on morphological characteristics and sequence data for the internal transcribed spacer (its-5.8s-its2) of the nuclear ribosomal dna. a new metabolite named chaetoglobosin x (1), together with three known compounds erogosterol (2), ergosterol 5α,8-peroside (3) and 2-methyl-3-hydroxy indole (4), were isolated from c. globosum l18. their structu ... | 2011 | 22112725 |
| Differential effects of foliar endophytic fungi on insect herbivores attacking a herbaceous plant. | Foliar endophytic fungi appear to be ubiquitous in nature, occurring in a very wide range of herbaceous plants. However, their ecological role within forbs is very poorly known and interactions with foliar-feeding insects virtually unexplored. In this study, leaves of Cirsium arvense were infected with different combinations of endophyte fungi that had been previously isolated from this plant species. Two months later, leaf material was fed to larvae of a generalist insect, Mamestra brassicae, a ... | 2011 | 21989607 |
| evolution of multicopper oxidase genes in coprophilous and non-coprophilous members of the order sordariales. | multicopper oxidases (mco) catalyze the biological oxidation of various aromatic substrates and have been identified in plants, insects, bacteria, and wood rotting fungi. in nature, they are involved in biodegradation of biopolymers such as lignin and humic compounds, but have also been tested for various industrial applications. in fungi, mcos have been shown to play important roles during their life cycles, such as in fruiting body formation, pigment formation and pathogenicity. coprophilous f ... | 2011 | 21966247 |
| genomic evidence of repeat-induced point mutation (rip) in filamentous ascomycetes. | the genomes of 49 filamentous ascomycetes (subphylum pezizomycotina) were examined by two independent methods for evidence of multiple c→t transitions typical of rip. at least one transposable element or other repeat family was identified in each genome, and members were assessed for transition and transversion mutations relative to a model of their intact progenitor. occurrence of rip was indicated where family members differed by excess of directional transitions over transversions. transition ... | 2011 | 20854921 |
| chaetoglocins a-d, four new metabolites from the endophytic fungus chaetomium globosum. | chaetoglocins a-d (1- 4), four new secondary metabolites, were isolated from the solid-fermentation culture of chaetomium globosum (strain no. ifb-e036), an endophytic fungus residing inside the root of cynodon dactylon. the structures of these compounds were elucidated on the basis of detailed spectroscopic evidence and by comparing spectroscopic data with those in the literature. compounds 1 and 2 displayed antimicrobial activity against the gram-positive bacteria with minimum inhibitory conce ... | 2011 | 20814854 |
| [two optimized transformation protocols for a cellulose-utilizing fungus chaetomium globosum nk-102]. | we developed the transformation methods of the strain chaetomium globosum nk-102. | 2011 | 22260047 |
| composition and antifungal activities of the leaf essential oil of neolitsea parvigemma from taiwan. | the hydrodistillated leaf essential oil of neolitsea parvigemma was analyzed to determine its composition and yield. sixty-two compounds were identified, the main components being beta-caryophyllene (14.2%), beta-eudesmol (12.9%), alpha-cadinol (10.2%) and tau-cadinol (8.8%). oxygenated sesquiterpenes (48.9%) and sesquiterpene hydrocarbons (48.8%) were the predominant groups of compounds. the antifungal indexes of the leaf oil against the 7 fungi, aspergillus clavatus, a. niger, chaetomium globo ... | 2011 | 21941915 |
| [fungal population structure and its biological effect in rhizosphere soil of continuously cropped potato]. | continuous cropping obstacle is one of the main restriction factors in potato industry. in order to explore the mechanisms of potato's continuous cropping obstacle and to reduce the impact on potato's tuber yield, a field experiment combined with pcr-dgge molecular fingerprinting was conducted to investigate the fungal population structure and its biological effect in rhizosphere soil of continuously cropped potato. with the increasing year of potato' s continuous cropping, the numbers of visibl ... | 2012 | 23431794 |
| chaetoglobosins and azaphilones produced by canadian strains of chaetomium globosum isolated from the indoor environment. | chaetomium globosum is one of the most common species of fungi found growing on damp building materials in north america and europe. at doses that could be experienced in a building with some mould damage, exposure to metabolites from other fungi results in inflammatory changes in vivo and in vitro. this research requires knowledge of the dominant toxins produced by fungal strains from the built environment and characterization of pure compounds for toxicity testing. we examined 25 strains of c. ... | 2012 | 23334724 |
| the application of bioactive compounds from the food industry to control mold growth in indoor waterborne coatings. | microbial growth in indoor environments creates health problems, especially in people with asthma; approximately 80% of these patients are allergic to mold. antimicrobial coatings are formulated to generate surfaces that are easy to clean and may also incorporate active agents, commonly called biocides, which inhibit microbial colonization, subsequent growth and bio-deterioration of the substrates. some research lines seek to replace traditional organometallic and organochlorines biocides with e ... | 2012 | 23298599 |
| season and tissue type affect fungal endophyte communities of the indian medicinal plant tinospora cordifolia more strongly than geographic location. | a total of 1,151 endophytic fungal isolates representing 29 taxa were isolated from symptom-less, surface-sterilized segments of stem, leaf, petiole, and root of tinospora cordifolia which had been collected at three locations differing in air pollution in india (ramnagar, banaras hindu university, maruadih) during three seasons (summer, monsoon, winter). endophytes were most abundant in leaf tissues (29.38% of all isolates), followed by stem (18.16%), petiole (10.11%), and root segments (6.27%) ... | 2012 | 22430503 |
| free tropospheric transport of microorganisms from asia to north america. | microorganisms are abundant in the troposphere and can be transported vast distances on prevailing winds. this study measures the abundance and diversity of airborne bacteria and fungi sampled at the mt. bachelor observatory (located 2.7 km above sea level in north america) where incoming free tropospheric air routinely arrives from distant sources across the pacific ocean, including asia. overall deoxyribonucleic acid (dna) concentrations for microorganisms in the free troposphere, derived from ... | 2012 | 22760734 |
| fungal life in the dead sea. | the waters of the dead sea currently contain about 348 g/l salts (2 m mg(2+), 0.5 m ca(2+), 1.5 m na(+), 0.2 m k(+), 6.5 m cl(-), 0.1 m br(-)). the ph is about 6.0. after rainy winters the surface waters become diluted, triggering development of microbial blooms. the 1980 and 1992 blooms were dominated by the unicellular green alga dunaliella and red archaea. at least 70 species (in 26 genera) of oomycota (chromista), mucoromycotina, ascomycota, and basidiomycota (fungi) were isolated from near- ... | 2012 | 22222829 |
| functional analysis of the degradation of cellulosic substrates by a chaetomium globosum endophytic isolate. | most photosynthetically fixed carbon is contained in cell wall polymers present in plant biomasses, the largest organic carbon source in the biosphere. the degradation of these polymers for biotechnological purposes requires the combined action of several enzymes. to identify new activities, we examined which enzymes are activated by an endophytic strain of chaetomium globosum to degrade cellulose-containing substrates. after biochemical analyses of the secretome of the fungus grown on cellulose ... | 2012 | 22389369 |
| a case report of a mixed chaetomium globosum/trichophyton mentagrophytes onychomycosis. | recently, an increasing prevalence of nondermatophyte mold onychomycosis was observed, in which chaetomium globosum was rarely involved as primary pathogenic agent. besides this, reports of mixed infection associating a dermatophyte and a nondermatophyte mold have become more frequent. here, we present a clinical case of a mixed onychomycosis infection of a toenail caused by chaetomium globosum and trichophyton mentagrophytes. to our knowledge, this specific association is reported for the first ... | 2012 | 24371744 |
| a pks gene, pks-1, is involved in chaetoglobosin biosynthesis, pigmentation and sporulation in chaetomium globosum. | chaetomium globosum is one of the most common fungi in nature. it is best known for producing chaetoglobosins; however, the molecular basis of chaetoglobosin biosynthesis is poorly understood in this fungus. in this study, we utilized rna interference (rnai) to characterize a polyketide synthase gene, pks-1, in c. globosum that is involved in the production of chaetoglobosin a. when pks-1 was knocked down by rnai, the production of chaetoglobosin a dramatically decreased. knock-down mutants also ... | 2012 | 23233225 |
| identification and characterization of the chaetoviridin and chaetomugilin gene cluster in chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase. | we report the identification and characterization of the caz biosynthetic cluster from chaetomium globosum and the characterization of a highly reducing polyketide synthase (pks) that acts in both a sequential and convergent manner with a nonreducing pks to form the chaetomugilin and chaetoviridin azaphilones. genetic inactivation studies verified the involvement of individual caz genes in the biosynthesis of the azaphilones. through in vitro reconstitution, we demonstrated the in vitro synthesi ... | 2012 | 23072467 |
| probing the role of sigma π interaction and energetics in the catalytic efficiency of endo-1,4-β-xylanase. | chaetomium globosum endo-1,4-β-xylanase (xylcg) is distinguished from other xylanases by its high turnover rate (1,860 s(-1)), the highest ever reported for fungal xylanases. one conserved amino acid, w48, in the substrate binding pocket of wild-type xylcg was identified as an important residue affecting xylcg's catalytic efficiency. | 2012 | 23023743 |
| endophytic chaetomium globosum enhances maize seedling copper stress tolerance. | this study aims at characterisation of the impact of chaetomium globosum on copper stress resistance of maize seedlings. higher levels of copper treatment decreased maize dry weight and induced a marked increase in osmotic solutes, antioxidant enzyme activity and the level of lipid peroxidation. on the other hand, addition of the endophytic c. globosum alleviated the toxic effect of copper on maize growth. the combination of copper sulphate and chaetomium increased seedling dry weight, osmotic s ... | 2012 | 22672065 |
| three new azaphilones produced by a marine fish-derived chaetomium globosum. | three new metabolites, chaetomugilin s, dechloro-chaetomugilin a and dechloro-chaetomugilin d, were isolated from a strain of chaetomium globosum originally obtained from the marine fish mugil cephalus, and their absolute stereostructures were elucidated based on the basis of spectroscopic analyses, including 1d and 2d nmr techniques and some chemical transformations. particularly, chaetomugilins t and u are the first compounds without a chlorine atom in azaphilones isolated from this fungal str ... | 2012 | 22617549 |
| chaetoglobosin vb from endophytic chaetomium globosum: absolute configuration of chaetoglobosins. | one new cytochalasan alkaloid, chaetoglobosin v(b) (1), together with two structurally related known compounds, chaetoglobosin v (2) and chaetoglobosin g (3), was isolated from the ethyl acetate extract of a culture of the endophytic fungus chaetomium globosum, associated with the leaves of ginkgo biloba tree. the structures of the isolated compounds were elucidated by spectroscopic methods including 1d and 2d nmr and mass spectrometry. the absolute configuration of chaetoglobosin v(b) (1) was e ... | 2012 | 22593034 |
| onychomycosis due to nondermatophytic molds. | although there have been many studies about onychomycosis due to nondermatophytic molds (ndm), few studies about etiologic agents including ndm in onychomycosis have been reported in korea. | 2012 | 22577268 |
| electrospray ionization tandem mass spectrometry of chaetoglobosins. | chaetoglobosins are a family of macrocyclic polyketide alkaloids. they possess many similar isomers and exhibit a wide range of biological activities. thus, there is a need for reliable, fast, and low-cost analysis of this class of compounds. | 2012 | 22886807 |
| differential chlorate inhibition of chaetomium globosum germination, hyphal growth, and perithecia synthesis. | chaetomium globosum kunze:fr is a dermatophytic, dematiaceous fungus that is ubiquitous in soils, grows readily on cellulolytic materials, and is commonly found on water-damaged building materials. chlorate affects nitrogen metabolism in fungi and is used to study compatibility among anamorphic fungi by inducing nit mutants. the effect of chlorate toxicity on c. globosum was investigated by amending a modified malt extract agar (mea), oat agar, and carboxymethyl cellulose agar (cmc) with various ... | 2012 | 22903379 |
| overexpressing transcriptional regulator in chaetomium globosum activates a silent biosynthetic pathway: evaluation of shanorellin biosynthesis. | 2012 | 22569160 | |
| biotransformation of gambogenic acid by chaetomium globosum cicc 2445. | microbial transformation of gambogenic acid (1), a caged polyprenylated xanthone isolated from the resin of garcinia hanburyi, was carried out with chaetomium globosum cicc 2445, after screening forty-six strains of filamentous fungi. a new caged polyprenylated xanthone, 16,17-dihydroxygambogenic acid (2), was specifically obtained, as a result of hydroxylation at c-16, and c-17. its structure was elucidated on the basis of spectroscopic methods. the cytotoxicity of compounds 1 and 2 against hel ... | 2012 | 22474955 |
| chaeoglobosin fex inhibits poly(i:c)-induced activation of bone marrow-derived dendritic cells. | dendritic cells (dcs) are implicated in the induction of autoimmune diseases and exist in lesions associated with several autoimmune inflammatory diseases. chaeoglobosin fex (cha fex), a cytochalasan-based alkaloid, was isolated from marine-derived endophytic fungus chaetomium globosum qen-14. in the present study, we evaluated the effect of cha fex on poly(i:c)-induced bone marrow-derived dcs. the results showed that cha fex attenuated the production of ifn-β both at the mrna and protein level ... | 2012 | 22424786 |
| cloning and expression of a small heat and salt tolerant protein (hsp22) from chaetomium globosum. | the present study reports molecular characterization of small heat shock protein gene in indian isolates of chaetomium globosum, c. perlucidum, c. reflexum, c. cochlioides and c. cupreum. six isolates of c. globosum and other species showed a band of 630bp using specific primers. amplified cdna product of c. globosum (cg 1) cloned and sequenced showed 603bp open reading frame encoding 200 amino-acids. the protein sequence had a molecular mass of 22 kda and was therefore, named hsp22. blastx anal ... | 2012 | 23305034 |
| monitoring the effects of different conservation treatments on paper-infecting fungi. | fungi are among the most degradative organisms inducing biodeterioration of paper-based items of cultural heritage. appropriate conservation measures and restoration treatments to deal with fungal infections include mechanical, chemical, and biological methods, which entail effects on the paper itself and health hazards for humans. three different conservation treatments, namely freeze-drying, gamma rays, and ethylene oxide fumigation, were compared and monitored to assess their short- (one mont ... | 2013 | 24092956 |
| targeted disruption of transcriptional regulators in chaetomium globosum activates biosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol. | postgenomic analysis revealed that many microorganisms carry numerous secondary metabolite biosynthetic genes on their genome. however, activities of those putative genes are not clearly reflected in the metabolic profile of the microorganisms, especially in fungi. a recent genome mining effort is promising in discovering new natural products. however, many fungi and other organisms are not amenable to molecular genetics manipulations, making the study difficult. here we report successful engine ... | 2013 | 23941144 |
| flavipin in chaetomium globosum cdw7, an endophytic fungus from ginkgo biloba, contributes to antioxidant activity. | 1,2-benzenedicarboxaldehyde-3,4,5-trihydroxy-6-methyl (flavipin) was found to be antagonistic against nematodes and fungi. here we demonstrated that flavipin is a potent antioxidant in vitro and in vivo, which has great potential in the therapy for free radical-associated diseases. therefore, flavipin-producing bio-source was screened from 80 endophytes in ginkgo biloba. seven endophytic fungi were able to synthesize antioxidant substances and identified by its rdna sequences. among them, chaeto ... | 2013 | 23740314 |
| onychomycosis caused by chaetomium globosum. | onychomycosis is usually caused by dermatophytes, but some nondermatophytic molds and yeasts are also associated with invasion of nails. the genus chaetomium is a dematiaceous nondermatophytic mold found in soil and plant debris as a saprophytic fungus. we report the first korean case of onychomycosis caused by chaetomium globosum in a 35-year-old male. the patient showed brownish-yellow discoloration and subungual hyperkeratosis on the right toenails (1st and 5th) and left toenails (1st and 4th ... | 2013 | 23717019 |
| combinatorial generation of complexity by redox enzymes in the chaetoglobosin a biosynthesis. | redox enzymes play a central role in generating structural complexity during natural product biosynthesis. in the postassembly tailoring steps, redox cascades can transform nascent chemical scaffolds into structurally complex final products. chaetoglobosin a (1) is biosynthesized by a hybrid polyketide synthase-nonribosomal peptide synthetase. it belongs to the chaetoglobosin family of natural products, comprising many analogs having different degrees of oxidation introduced during their biosynt ... | 2013 | 23611317 |
| intracellular targeting of ascomycetous catalase-peroxidases (katg1s). | bifunctional catalase-peroxidases (katgs) are heme oxidoreductases widely spread among bacteria, archaea and among lower eukaryotes. in fungi, two katg groups with different localization have evolved, intracellular (katg1) and extracellular (katg2) proteins. here, the cloning, expression analysis and subcellular localization of two novel katg1 genes from the soil fungi chaetomium globosum and chaetomium cochliodes are reported. whereas, the metalloenzyme from ch. globosum is expressed constituti ... | 2013 | 23589225 |
| cytotoxic azaphilone alkaloids from chaetomium globosum ty1. | three novel azaphilone alkaloids, namely chaetomugilides a-c (1-3), together with three related compounds (4-6) were isolated from the methanol extract of chaetomium globosum ty1, an endophytic fungus isolated from ginkgo biloba. their structures were elucidated on the basis of extensive 1d and 2d nmr as well as hresi-ms spectroscopic data analysis. the isolated compounds exhibited highly cytotoxic activities against human cancer cell line hepg2 with the ic50 values range from 1.7 to 53.4μm. | 2013 | 23562244 |
| identification of antifungal principle in the solvent extract of an endophytic fungus chaetomium globosum from withania somnifera. | extracts of chaetomium globosum ef18, isolated as endophytic fungus from withania somnifera, were found effective against sclerotinia sclerotiorum. ethyl acetate and methanol extracts were more effective than hexane extract showing >80% growth inhibition. bioactive compound (antibiotic sch 210971, m/z 445 and λmax 290) having antifungal activity against s. sclerotiorum has been isolated in pure form from the ethyl acetate extract following bioassay guided fractionation. apart from this compound ... | 2013 | 23519550 |
| characterization of an antigenic chitosanase from the cellulolytic fungus chaetomium globosum. | we are interested in identifying human fungal allergens and antigens from species common on water-damaged or damp building materials for use as marker proteins and diagnostic tests. the cellulolytic fungus chaetomium globosum is common on damp materials in the building environment worldwide. elisa and immunoblotting tests identified two related proteins of molecular weights 45 and 47 kda which were identified as fungal antigens found on spore surfaces and in culture filtrate. the sequences were ... | 2013 | 22985087 |