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rat-bite fever in a gerbil breeder.a case of rat-bite fever caused by streptobacillus moniliformis in a gerbil-breeder is described. such a case has not been previously recorded.19883351317
fatal streptobacillus moniliformis infection in a two-month-old infant.streptobacillus moniliformis is an uncommon human pathogen contracted from exposure to rodents. it usually produces a mild, protracted illness (rat-bite fever, haverhill fever, erythema arthriticum epidemicum) that has either a favorable response to antibiotic therapy or spontaneously resolves. this report describes a fatal case of streptobacillus moniliformis in an infant bitten by a wild rat. the autopsy findings included an interstitial pneumonia, fibrinous endocarditis, mild mononuclear meni ...19892718962
streptobacillus moniliformis epizootic in barrier-maintained c57bl/6j mice and susceptibility to infection of different strains of mice.we report a streptobacillus moniliformis epizootic in barrier-maintained spf mice. although various inbred and f1 hybrid strains of mice have been kept in this animal facility, only c57bl/6j han [corrected] mice showed clinical signs of disease. during the course of the epizootic, 825 breeding animals (approximately 36% of the breeders) died or had to be killed because of severe clinical signs. although sequential treatment with ampicillin and chlortetracycline gave good therapeutic results, the ...19902172624
[arthritis caused by streptobacillus moniliformis: a case of fever induced by a rat bite].a 54-year-old female had fever with chills, polyarthritis and diffuse rash. anamnesis led to the suspicion of rat-bite fever. the etiology was confirmed when and organism which was identified as streptobacillus moniliformis was isolated from articular fluid by means of gas chromatography of tissue fatty acids. in our opinion, this is the first case of that condition reported in this country. we review the literature, and we insist on the need to inform the microbiologist of the clinical suspicio ...19902192206
[pathological changes in streptobacillus moniliformis infection of c57bl/6j mice].an epizootic disease caused by streptobacillus moniliformis occurred in c57bl/6j mice. pathological lesions included abscessation of lymph nodes and chronic polyarthritis and osteomyelitis. histological features of the disease are described. the most important differential diagnosis, infectious ectromelia of mice, is discussed.19902317186
scanning and transmission electron microscopic observations of bacteria adhering to ileal epithelial cells in growing broiler and white leghorn chickens.1. bacteria adhering to the ileal epithelial cells in broiler and white leghorn (wl) chickens aged 1 to 60 d were observed with scanning (sem) and transmission (tem) electron microscopes. 2. in sem observations, bacteria were not found on day 1 after hatching in either breed. in 10-d-old broilers many bacteria were observed around the apical area of villi. the number decreased with age and disappeared by 50 d. in wl chicks, the bacteria were first observed at 20 d. numbers were much fewer than i ...19902354369
isolation of streptobacillus moniliformis from the middle ear of rats.streptobacillus moniliformis was isolated from the middle ear of 9 of 16 rats used for otological studies. examination of rat sera for the presence of anti-streptobacillus moniliformis antibodies using an elisa technique resulted in 15 seropositive animals. the source of the s. moniliformis infection was not determined.19911826334
[acute purulent polyarthritis induced by streptobacillus moniliformis]. 19911835055
rat bite fever in a greek child.rat bite fever was diagnosed in a 10-year-old boy in a rural area of south-west greece. the clinical presentation was typical for this disease and the relevant causative agent (streptobacillus moniliformis) was isolated from blood cultures of the febrile patient. erythromycin treatment was efficient. although extremely rare in continental europe, this infection must be taken into account as a potential hazard of a rat bite.19921411320
rat bite fever (streptobacillus moniliformis) with septicemia in a child.a 5-year-old girl was admitted to hospital with fever, headache and nausea. her c-reactive protein raised from less than 11 mg/l to 65 mg/l and she developed a maculopapular, petechial rash, especially pronounced on the soles and palms. after incubation for 3 days, streptobacillus moniliformis was found in all blood cultures that had been taken. some weeks before her admission, the girl had been playing with her grandmother's pet rats, which later had died from an unknown disease. there was no h ...19921411321
isolation of streptobacillus moniliformis from a guinea pig with granulomatous pneumonia. 19921460856
streptobacillus moniliformis isolated from otitis media of conventionally kept laboratory rats.streptobacillus moniliformis (sm) was isolated from the middle ear of two inbred albino rats (strain cap/kuv) suffering from murine respiratory mycoplasmosis and purulent bilateral otitis media. the animals were kept under conventional conditions and used for immunological studies. the biochemical pattern of the isolate was identical with that of four other sm strains of different origin but differed in its ability to lyse erythrocytes in sheep blood agar. this is the first sm strain with hemoly ...19921534999
streptobacillus moniliformis endocarditis: case report and review.a 46-year-old man with rat-bite fever due to streptobacillus moniliformis that was complicated by endocarditis is reported. other unusual features of this case include septic arthritis with prominent involvement of the sternoclavicular joint and the absence of a rash. sixteen cases of streptobacillary endocarditis have previously been described. this condition occurs most often in the setting of previously damaged heart valves, usually as a result of rheumatic heart disease. echocardiography dem ...19921562665
rat bite fever without the bite.the case is reported of a patient who developed an acute arthropathy, which was initially diagnosed as acute septic arthritis. the true diagnosis of rat bite fever due to streptobacillus moniliformis was delayed because of difficulty in growing the organism, which has fastidious growth requirements. the patient had no history of rat bite, which is the usual form of transmission of this disease.19921575596
dog-associated bacterial infections in humans: isolates submitted to an australian reference laboratory, 1981-1992.over the period 1981-92, 32 bacterial isolates were referred to the microbiological diagnostic unit from infected dog-bite wounds and 10 isolates were submitted from blood cultures after dog bites or close contact with dogs. the isolates from the bite wounds were identified, or confirmed, as pasteurella multocida (11 isolates), pasteurella dagmatis (3), cdc group m-5 (9), cdc group ef-4a (8) and streptococcus anginosus (1). five of the 9 patients from whom cdc group m-5 was cultured had mixed in ...19938165003
[streptobacillus moniliformis: a rare anthropozoonosis sometimes observed in urban area]. 19938210127
an enzyme-linked immunosorbent assay (elisa) for monitoring rodent colonies for streptobacillus moniliformis antibodies.an enzyme-linked immunosorbent assay (elisa) to measure streptobacillus moniliformis antibodies in mice and rats was developed. twelve s. moniliformis strains originating from cases of rat-bite fever and haverhill fever in man and from various rodent species, showed considerable serological relationship. the elisa appeared specific since antibodies to s. moniliformis were absorbed by autologous and homologous antigen, but not by heterologous bacterial antigens. acholeplasma laidlawii showed part ...19938277708
[rat-bite--an infant bitten by a rat].three days after a rat-bite a two-month-old girl developed clinical symptoms of streptobacillus moniliformis infection, called rat-bite fever. she became seriously ill, but responded well to treatment with benzylpencillin. in the light of our case and previous publications, we recommend prophylactic penicillin to be given to infants after rat-bites.19938316977
cutaneous abscess: a rare complication of streptobacillus moniliformis infection. 19938369220
polyarthritis in wild mice (mus musculus) caused by streptobacillus moniliformis.mice trapped on farms in south-eastern queensland had chronic abscessating osteoarthritides mainly involving the carpi and tarsi. pleomorphic bacteria were shown by silver staining to be plentiful within lesions. streptobacillus moniliformis was isolated from the joints, and streptobacillary polyarthritis was diagnosed. other lesions observed included subcutaneous and hepatic abscesses.19948067948
streptobacillus moniliformis infection in a child with chickenpox. 19948072828
rat-bite fever caused by streptobacillus moniliformis. 19947667732
streptobacillus moniliformis--a zoonotic pathogen. taxonomic considerations, host species, diagnosis, therapy, geographical distribution.streptobacillus moniliformis (sm), the causative agent of rat-bite fever and haverhill fever in man, is also a pathogen in certain laboratory and domestic animals. with the introduction of modern maintenance systems, this microorganism seemed to be eradicated from laboratory animal units, but recent reports of streptobacillus moniliformis (sm) in colonies of laboratory rodents give evidence that this 'forgotten' bacterium can still be found even behind hygienic barrier systems. although various ...19957707673
difficulties encountered in identification of a nutritionally deficient streptococcus on the basis of its failure to revert to streptococcal morphology.difficulties were encountered in the recognition of a nutritionally deficient streptococcus which continued to display aberrant morphologic forms (especially bulbous swellings and filament formation) despite provision of growth factors. with isolates displaying diverse morphologic entities not characteristic of a given species, e.g., streptobacillus moniliformis or erysipelothrix rhusiopathiae, nutritionally deficient streptococci should be considered.19957790428
mutual viral and bacterial infections after housing rats of various breeders within an experimental unit.fifteen athymic rat strains from 11 breeding colonies were housed within an experimental facility for an immunological study. health status records supplied with 14 of the strains listed infections by kilham's rat virus (krv), clostridium piliforme (bacillus piliformis) and pasteurella pneumotropica for 2, 2 and 1 colonies respectively. in sera taken previous to the study from euthymic rats of 10 strains, antibodies to krv were detected in 3 strains, to pneumonia virus of mice (pvm), rat corona ...19968709572
streptobacillus moniliformis infection in swiss white mice.an epizootic of disease attributed to infection with streptobacillus moniliformis occurred in a colony of swiss white mice. the mortality rate among the 180 breeding females in the 6 affected pens was 100%, and most of the sucking young died from starvation. acute septicemia, subacute septicemia, and polyarthritis were the 3 forms of disease observed. clinically, septicemic mice either were found dead or were depressed and hunched for 1-2 days prior to death. about a half of these mice had brown ...19968744742
[streptobacillus moniliformis septic oligoarthritis (fever caused by rat bite)]. 19968767083
isolation of presumptive streptobacillus moniliformis from abscesses associated with the female genital tract.we report three cases in which streptobacillus moniliformis was isolated from abscesses. abscess material in each case contained small, pleomorphic, gram-negative to gram-variable bacilli. anaerobic blood agar cultures yielded pinpoint colonies adjacent to small gray-white colonies. the pinpoint colonies did not gram stain, and the gray-white colonies varied from gram-variable coccobacilli to long, curly, gram-variable rods. the pinpoint colonies microscopically resembled l-forms on dienes-stain ...19968852965
rat-bite fever--new mexico, 1996.rat-bite fever (rbf) is a systemic bacterial illness caused by streptobacillus moniliformis that can be acquired through the bite or scratch of a rodent or the ingestion of food or water contaminated with rat feces. cases are rarely reported in the united states and the true incidence of disease is unknown. on august 7, 1996, a physician in a rural community reported a case of infection with s. moniliformis bacteremia in a 15-year-old boy to the new mexico department of health. this report summa ...19989480409
rat bite fever in a pet lover.rat-bite fever is an uncommon bacterial illness resulting from infection with streptobacillus moniliformis that is often transmitted by the bite of a rat. the cutaneous findings in rat-bite fever are nonspecific but have been described as maculopapular or petechial. we describe a 9-year-old girl with acrally distributed hemorrhagic pustules, fever, and arthralgias. diagnosis was delayed because of difficulty in identifying the pathologic organism. she was successfully treated with 10 days of cef ...19989486709
streptobacillus moniliformis infection: 2 cases and a literature review.two cases of streptobacillus moniliformis infection are reported in farmers bitten by rats during their work. one patient had a subcutaneous abscess requiring surgical treatment and the other streptobacillary rat bite fever. streptobacillus moniliformis was isolated from pus and blood, respectively. an erythromycin course failed to eradicate the infection in the first patient. both patients were successfully treated with penicillin.19989790145
streptobacillus moniliformis endocarditis in an hiv-positive patient.streptobacillus moniliformis is the causative agent of rat bite fever, with endocarditis being a rare but well-documented complication. we report the case of an hiv-positive man who acquired s. moniliformis endocarditis through a rat bite. no predisposing cardiac lesion was known. he was treated with ceftriaxone 2 g/day i.v. for 3 weeks, gentamicin 120 mg/day i.v. for 2 weeks and penicillin 24x10(6) units/day for 1 week. at the end of the antibiotic therapy he suffered a generalized candida albi ...200011139161
septic arthritis of the hip secondary to rat bite fever: a case report.rat bite fever is a rare infection typically caused by streptobacillus moniliformis. the mode of transmission is most commonly through a bite or scratch from an infected rat. this disease is characterized by polyarthritis, fever, and a delayed onset erythematous maculopapular rash of the extremities. the authors report a case of rat bite fever, which led to septic arthritis of the hip. to the authors' knowledge, the complication of hip sepsis requiring an arthrotomy has not been reported in the ...200011064988
streptobacillus moniliformis: case report and review of the literature.streptobacillus moniliformis is one of the causes of rat bite fever. the clinical and microbiological diagnosis of this rare infectious disease is often quite problematic. penicillin, in sufficiently high dosis, is the treatment of choice and leads to a prompt resolution of the infection, whereas lack of treatment leads to a 13% mortality rate. as far as we know, this paper reports the first human isolate in belgium.200111484516
remitting seronegative symmetrical synovitis with pitting edema associated with subcutaneous streptobacillus moniliformis abscess.we describe an 84-year-old woman who developed remitting seronegative symmetrical synovitis with pitting edema (rs3pe) associated with a subcutaneous abscess of the hand due to streptobacillus moniliformis. polyarthritis and edema were relieved after therapy with corticosteroids. we review the association of rs3pe to different rheumatologic, neoplastic, or infectious diseases.200111469482
a rare and serious consequence of a rat bite.contact with rat saliva or faeces can lead to infection with streptobacillus moniliformis and the condition known as 'rat bite fever'. we report a case of septic arthritis of the hip due to this organism following a bite on the finger of a 14-year-old boy from a rat for sale in a pet shop. the case was successfully treated by arthrotomy, drainage and joint lavage followed by administration of penicillin. septic arthritis of the hip due to s. moniliformis has not been previously described and thi ...200111518380
rat-bite fever (streptobacillus moniliformis): a potential emerging disease.to determine the relative prevalence of human infections attributable to streptobacillus moniliformis in california over the past 3 decades.200111724672
broad range polymerase chain reaction for diagnosis of rat-bite fever caused by streptobacillus moniliformis.an 11-year-old boy presented with fever, vomiting, rash, limping and blisters on his feet after a finger bite by his domestic rat. although cultures from blood, cerebrospinal fluid and urine remained negative, broad range polymerase chain reaction amplification of a part of the 16s rrna gene followed by sequencing allowed the detection and identification of streptobacillus moniliformis in blister fluid, thus confirming the suspected clinical diagnosis of rat-bite fever.200111740332
[rat-bite fever].rat bite fever and haverhill fever are caused by streptobacillus moniliformis which is part of the natural oral flora of rats and other rodents. fever accompanied by headache, nausea and myalgia develops within ten days. complications can be fatal.200111757440
pcr for the detection of streptobacillus moniliformis.streptobacillus moniliformis is a gram-negative bacterium found in various laboratory animal species and is the cause of rat bite fever and haverhill fever in man. in order to evaluate a polymerase chain reaction (pcr) for the detection of this zoonotic bacterium in animal tissues a set of primers was designed based on the dna base sequence of part of the 16s rrna gene from 11 s. moniliformis strains. the pcr detected as few as 2-6 copies of s. moniliformis dna. a 296 bp dna fragment was amplifi ...200211943086
[digital purpura revealing septicaemical rat-bite fever].infection with streptobacillus moniliformis is an uncommon illness which can lead to death if untreated. we report the case in which initially cutaneous signs permitted diagnosis and further identification of the organism.200212442129
spontaneous rat bite fever in non-human primates: a review of two cases.rat bite fever is a worldwide zoonotic, non-reportable disease. this entity encompasses similar, yet distinct, disease syndromes caused by streptobacillus moniliformis or spirillum minus. naturally occurring rat bite fever has not been previously described in non-human primates. this report describes two cases of non-human primate rat bite fever caused by s. moniliformis; a rhesus macaque (macaca mullata) with valvular endocarditis, and a titi monkey (callicebus sp.) with septic arthritis. poten ...200212519213
[acute fever due to rats].the bite of a rat can transmit diverse micro-organisms; however, the development of health measures and the improved conditions of habitability of homes have meant that the infectious diseases transmitted by the aggressions of these animals are infrequent in industrialised countries. in occasional circumstances this type of aggression can still take place, especially in depressed areas on the periphery of big cities and in uninhabited premises, this being a possibility that it is advisable to be ...200212861297
rat-bite fever in children: case report and review.we report 2 cases of rat-bite fever (rbf), a multisystem zoonosis, in children and review the literature. rbf is caused by i of 2 gram-negative organisms: streptobacillus moniliformis or, less commonly, spirillum minus. both of our cases developed in school-aged girls with a history of rat exposure who presented with a multisystem illness consisting of fever, petechial and purpuric rash, arthralgia and polyarthritis. both responded promptly to antibiotic treatment. an additional 10 cases from a ...200212160180
rat bite fever without fever.rat bite fever is a rarely reported acute febrile bacterial illness caused by streptobacillus moniliformis or spirillum minus following a rat bite. it is classically characterised by abrupt onset of fever with rigors, myalgias, headache, and the appearance of a generalised maculopapular petechial skin rash. polyarthritis complicates the course of the disease in up to 50% of infected patients, and numerous hurdles can make the diagnosis particularly difficult in the absence of fever or rash, as i ...200312922966
molecular diagnosis of arthritis due to streptobacillus moniliformis.streptobacillus moniliformis was identified as etiologic agent of arthritis utilizing a 16s rdna molecular kit in our clinical laboratory. with the increasing of human contacts with rat as pet, this method would appear suitable to identify fastidious gram-negative rod involved in arthritis specially when the clinical context is not evocative.200314711486
bacteremia by streptobacillus moniliformis: first case described in spain.described here is the case of an 87-year-old man who developed fever, chills and discomfort caused by streptobacillus moniliformis. this pathogen is one of the causes of rat-bite fever, an uncommon bacterial illness transmitted through a bite or scratch from a rodent or the ingestion of food or water contaminated with rat faeces. cases of rat-bite fever are rarely reported in spain. the patient reported no history of rat bite or rodent contact, and the only known risk factor was contact with a d ...200312709841
rat bite fever caused by streptobacillus moniliformis in a child: human infection and rat carriage diagnosed by pcr.a child owning pet rats developed an eruptive fever with blisters, polyarthritis, and spectacular desquamation of the hands. streptobacillus moniliformis was identified after culture of the child's blister fluid and was detected in rat samples by molecular methods. such detection in the pet of a human victim of rat bite fever has not been reported previously.200516254115
rat-bite fever.a 23-year-old woman presented with fever, arthralgias and a skin rash. she possessed nine pet rats, and denied that she had been bitten. blood culture was positive for streptobacillus moniliformis, which can cause rat-bite fever. the patient fully recovered after treatment with clarithromycin.200516186643
rat bite fever mimicking rheumatoid arthritis.we report a case of streptobacillus moniliformis polyarthritis mimicking a rheumatoid arthritis, in a pet shop employee. in culture of fluid joint growth a curious gram-negative bacillus was identified by polymerase chain reaction as streptobacillus moniliformis. the outcome was good after surgical debridment and rifampin-clindamycin combination during 4 weeks.200516012023
fatal rat-bite fever--florida and washington, 2003.rat-bite fever (rbf) is a rare, systemic illness caused by infection with streptobacillus moniliformis. rbf has a case-fatality rate of 7%-10% among untreated patients. s. moniliformis is commonly found in the nasal and oropharyngeal flora of rats. human infection can result from a bite or scratch from an infected or colonized rat, handling of an infected rat, or ingestion of food or water contaminated with infected rat excreta. an abrupt onset of fever, myalgias, arthralgias, vomiting, and head ...200515635289
streptobacillus moniliformis endocarditis. 200616752478
haverhill fever with spine involvement.haverhill fever and rat-bite fever are closely-related syndromes caused by streptobacillus moniliformis. this infection is characterized by the abrupt onset of fever with rigors, myalgias, headache, polyarthritis, and rash. we report a case of infection with s. moniliformis that manifested as acute polyarthritis with involvement of the spine. to our knowledge, involvement of the spine has not been reported previously with this infection. diagnosis can be particularly difficult in the absence of ...200616821275
detection of antibodies to streptobacillus moniliformis in rats by an immunoblot procedure.an immunoblot (ib) technique for detecting antibodies to streptobacillus moniliformis in rat sera was evaluated. immune sera to three s. moniliformis strains showed a similar reactivity pattern with both autologous and homologous antigens in the 18-87 kda range. using a rat s. moniliformis strain as the antigen, a similar reactivity pattern was found with sera from rats infected experimentally with s. moniliformis and sentinels. two to five proteins were detected in the 32-55 kda range. over a p ...200617018215
rat-bite fever septic arthritis: illustrative case and literature review.rat-bite fever is a rare zoonotic infection caused by streptobacillus moniliformis or spirillum minus, which is characterised by fever, rash and arthritis. the arthritis has previously been described as non-suppurative and isolation of the organism from synovial fluid as very uncommon. this article reports a case of septic arthritis diagnosed as rat-bite fever when the organism was cultured from synovial fluid and reviews another 15 cases of s. moniliformis septic arthritis reported in the world ...200617096137
rat bite fever and streptobacillus moniliformis.rat bite fever, caused by streptobacillus moniliformis, is a systemic illness classically characterized by fever, rigors, and polyarthralgias. if left untreated, it carries a mortality rate of 10%. unfortunately, its nonspecific initial presentation combined with difficulties in culturing its causative organism produces a significant risk of delay or failure in diagnosis. the increasing popularity of rats and other rodents as pets, together with the risk of invasive or fatal disease, demands inc ...200717223620
rat-bite fever: a cautionary tale.we present the first ever report of streptobacillary rat-bite fever in new zealand. the patient was a young man who was admitted with systemic sepsis. he presented with a high fever, hypotension, and tender axillary lymphadenopathy. he had been bitten by a rat a week earlier. blood cultures grew streptobacillus moniliformis, thus confirming the diagnosis. the literature on rat-bite fever is also reviewed.200717515945
streptobacillus moniliformis septic arthritis: a clinical entity distinct from rat-bite fever?streptobacillus moniliformis is a zoonotic agent associated with rodent contacts. although it is more commonly reported to cause rat-bite fever with reactive arthritides, it can also lead to pyogenic infection of the joints.200717561996
fulminant endocarditis caused by streptobacillus moniliformis in a young man. 200718023687
prosthetic valve endocarditis caused by streptobacillus moniliformis: a case of rat bite fever.we report a case of rat bite fever caused by streptobacillus moniliformis in taiwan. it manifested as prosthetic valve endocarditis, which was cured by cardiac valve replacement and antimicrobial therapy. the dna sequence of the 16s rrna gene of s. moniliformis was detected in valve specimens by pcr and nucleotide sequencing.200717652475
[pet-rat bite fever and septic arthritis: molecular identification of streptobacillus moniliformis].pet-rat bite fever is a relatively rare disease consecutive to a rat bite or scratch. the authors report a case of septic arthritis following a pet rat bite. streptobacillus moniliformis was identified in the knee synovial fluid and identified by 16s rrna sequencing. this is a rapid and efficient tool for identification of fastidious bacterium. the patient was cured by an amoxicillin treatment.200717257794
rat-bite fever identified by polymerase chain reaction detection of streptobacillus moniliformis dna.a 74-year-old woman presented with erythema of the extremities, a high fever and arthralgia after being bitten by a rat. the patient was diagnosed as having rat-bite fever based on the symptoms and clinical course, as well as the polymerase chain reaction detection of streptobacillus moniliformis dna in the crust of the bite site. this is the first case to be diagnosed using polymerase chain reaction on a crusted skin lesion specimen. although clinical symptoms initially remitted with minocyclin ...200819017047
dogs as vectors of streptobacillus moniliformis infection?rat bite fever is a bacterial zoonosis transmitted through the bite of rats. one of the two etiological agents that cause rat bite fever is streptobacillus moniliformis. rat bite fever is rare and very likely under diagnosed but occurs worldwide. other animals, like dogs and cats that have mouthed a rat are often mentioned in the literature as potential risks for the attraction of rat bite fever. however, rat bite fever caused by the bite of a dog or cat has very seldom been documented. therefor ...200818061376
positive streptobacillus moniliformis pcr in guinea pigs likely due to leptotrichia spp.streptobacillus moniliformis is a zoonotic bacterium. we obtained positive s. moniliformis pcr results in oral swab samples from guinea pigs from an experimental colony and the breeding colony of origin. comparison of the dna sequence of an amplicon with deposited 16s rdna sequences revealed that leptotrichia sp. can be the source of a false positive s. moniliformis pcr outcome.200818023543
detection of streptobacillus spp. in feral rats by specific polymerase chain reaction.streptobacillus moniliformis is an etiological agent of rat-bite fever and haverhill fever in human infection. as the currently available methods for identifying the causative bacteria are not satisfactory, we attempted to establish them by pcr using newly designed primers for the 16s rrna gene of s. moniliformis. we then determined the prevalence of streptobacillus spp. in two species of feral rats that inhabit an urban region in japan, because information on the prevalence of the bacteria in f ...200818352907
isolation of streptobacillus moniliformis from a pet rat.we isolated streptobacillus moniliformis, the causative agent of rat-bite fever in humans, from the salivary gland of a pet rat postmortem. the isolate was a gram-negative pleomorphic coccobacillus, which produced acid from glucose and showed enzymatic activities for eight items in the api zym system. the results were consistent with those of the reference strain, atcc 14647(t), except for acid production from dextrin. partial sequencing of 16s rrna (1,440 bp) and gyrb genes (514 bp) of the isol ...200818525173
streptobacillus moniliformis as the causative agent in spondylodiscitis and psoas abscess after rooster scratches.we report a case of streptobacillus moniliformis spondylodiscitis accompanied by a psoas abscess in an 80-year-old man scratched by a rooster. s. moniliformis was identified from abscess fluid by use of 16s rrna gene sequencing. after 18 weeks of antimicrobial therapy, the clinical condition of the patient improved.200818562588
[zoonoses transmitted by mouse and rat maintained as laboratory or pet animals].large numbers of mice (mus spp.) and rats (rattus spp.) are maintained for scientific reasons and as pet animals in germany. while laboratory animals are monitored for pathogenic agents, the hygienic status of pet animals is usually completely unknown. despite great efforts, zoonotic infections were reported even in laboratory settings, e.g. with hantavirus (seoul virus), streptobacillus moniliformis, and trichphyton mentagrophytes. however, in current reports, zoonotic infections were transmitt ...200818712260
rainfall and outbreaks of drinking water related disease and in england and wales.a case-crossover study compared rainfall in the 4 weeks before drinking water related outbreaks with that in the five previous control years. this included public and private drinking water related outbreaks in england and wales from 1910 to 1999. of 111 outbreaks, 89 met inclusion criteria and the implicated pathogens included giardia, cryptosporidium, e. coli, s. typhi, s. paratyphi, campylobacter and streptobacillus moniliformis. weather data was derived from the british atmospheric data cent ...200918957770
complete genome sequence of streptobacillus moniliformis type strain (9901).streptobacillus moniliformis levaditi et al. 1925 is the type and sole species of the genus streptobacillus, and is of phylogenetic interest because of its isolated location in the sparsely populated and neither taxonomically nor genomically much accessed family 'leptotrichiaceae' within the phylum fusobacteria. the 'leptotrichiaceae' have not been well characterized, genomically or taxonomically. s. moniliformis,is a gram-negative, non-motile, pleomorphic bacterium and is the etiologic agent of ...200921304670
rat bite fever: a misnomer?we report a case of rat bite fever (streptobacillus moniliformis) in a young man who presented generally unwell with pyrexia, vomiting, arthralgia and deranged liver function. two weeks before his illness he had disposed of a dead rat but was not bitten by it. this zoonotic infection was treated with broad spectrum antibiotics and he made a complete recovery. it is a rarely diagnosed but likely common infection given the frequent contact between humans and rodents. in the past, confirmation of t ...200922180758
the rise of the rats: a growing paediatric issue.rat bite fever (rbf), a systemic infection of streptobacillus moniliformis or spirillum minus characterized by fever, arthralgias and petechial-purpuric rash on the extremities, carries a mortality rate of 7% to 10% if untreated. in canada, one adult and two paediatric cases of rbf have been reported since 2000. in recent years, pet rats have become quite popular among children, placing them at an increased risk for rbf. thus, paediatricians need to be more wary of the potential for rbf in their ...201021358889
[unexplained fever after exposure to rats: rat bite fever or haverhill fever].a 24-year old man presented himself to the emergency ward with complaints of fever, nausea, headache, muscle ache and chest pain. two weeks before presentation he had been bitten by a pet rat. we determined that he had bacteraemia caused by a streptobacillus moniliformis infection, which led to the development of an illness called rat bite fever. s. moniliformis is a pleomorphic gram-negative rod-shaped bacterium that is considered part of the normal nasopharyngeal flora in rats. it is the cause ...201020619014
streptobacillus moniliformis bacteremia in a child: case report.background: we report a case of bacteremia caused by streptobacillus moniliformis. case presentation and intervention: a 2 years and 3 months female kuwaiti child presented with febrile convulsions, mild cough and vomiting. the patient's history, clinical findings and radiological investigations were reviewed. there was no history of rat/animal bite, but the child had been camping in the desert prior to the illness and may have been exposed to rodent excreta. on two occasions, blood culture spec ...201020639668
isolation of streptobacillus moniliformis from the blood of a child with acute lymphoblastic leukaemia.this is an unusual report of isolation of streptobacillus moniliformis from the blood of a male child with acute lymphoblastic leukaemia. no history of rat bite was there, but rats were present in the house. the possible source of infection may be food or water contaminated with rat excreta. whether this bacteria can cause opportunistic infection in leukaemic patients, need to be evaluated further.201020966577
a case of septic arthritis from rat-bite fever in hawai'i.infection associated with a rat bite has been known for centuries. streptobacillus moniliformis is a zoonotic organism identified in the 20th century as the causative agent of most cases of rat bite fever outside of mainland asia. there are no previously published cases of this pathogen in hawai'i.201020397505
rat bite fever, a fatal case of streptobacillus moniliformis infection in a 14-month-old boy.streptobacillus moniliformis is the primary cause of rat bite fever in north america. children under 12 years of age are primarily infected, presenting with an acute syndrome of fever, rash, and polyarthritis. common vectors include rats and mice. transmission is predominantly from a bite or scratch, but contact with or ingestion of food contaminated with feces or saliva has also been reported. we report a fatal case of s. moniliformis infection in a 14-month-old-boy. at home, the child was expo ...201121306374
[streptobacillus moniliformis septic polyarthritis]. 201121397421
[streptobacillus moniliformis]. 201121526287
a 70-year-old man with fever and polyarthralgia. streptobacillus moniliformis. 201122002981
rat bite fever as a presenting illness in a patient with aids.the etiology of culture-negative septic arthritis is poorly characterised in persons infected with human immunodeficiency virus (hiv). new molecular methods may assist in the investigation of culture-negative infections of sterile sites, including septic arthritis. we describe the first case of septic arthritis due to the cause of rat bite fever (rbf), streptobacillus moniliformis, confirmed by 16s rrna sequence analysis, in a patient with newly diagnosed hiv infection.201121877181
Characterization of ß-galactoside phosphorylases with diverging acceptor specificities.Glycoside phosphorylases are a special group of carbohydrate-active enzymes, with characteristics in between those of glycoside hydrolases and glycosyl transferases. The phosphorylases from family GH-112 are exceptional because they employ galactose-1-phosphate instead of glucose-1-phosphate as glycosyl donor. Different acceptor specificities have been observed in this family, ranging from l-rhamnose to GlcNAc, GalNAc and a combination of the latter. Three new phosphorylases from previously unex ...201122112272
shell vial cell culture as a tool for streptobacillus moniliformis "resuscitation".streptobacillus moniliformis is a fastidious growing gram-negative bacillus responsible of rat-bite fever. we describe here the first report of this disease in la réunion and the first isolation using shell vial cell culture from a blood culture bottle with a bacterium suspected to be dead.201121292904
epidural abscess caused by streptobacillus moniliformis.we present an interesting case of a patient who developed an epidural abscess caused by streptobacillus moniliformis. this is the first report in the medical literature of a spinal epidural abscess associated with this organism. diagnosis of s. moniliformis infection requires a high degree of suspicion, and a delay may be inevitable when a relevant clinical history is lacking.201222718932
septic arthritis and concern for osteomyelitis in a child with rat bite fever.rat bite fever is a rare infection usually caused by streptobacillus moniliformis. a case of septic arthritis and possible osteomyelitis as sequelae of rat bite fever in a pediatric patient is described.201323554193
rats, cities, people, and pathogens: a systematic review and narrative synthesis of literature regarding the ecology of rat-associated zoonoses in urban centers.urban norway and black rats (rattus norvegicus and rattus rattus) are the source of a number of pathogens responsible for significant human morbidity and mortality in cities around the world. these pathogens include zoonotic bacteria (leptospira interrogans, yersina pestis, rickettsia typhi, bartonella spp., streptobacillus moniliformis), viruses (seoul hantavirus), and parasites (angiostrongylus cantonensis). a more complete understanding of the ecology of these pathogens in people and rats is ...201323590323
detection of zoonotic pathogens and characterization of novel viruses carried by commensal rattus norvegicus in new york city.norway rats (rattus norvegicus) are globally distributed and concentrate in urban environments, where they live and feed in closer proximity to human populations than most other mammals. despite the potential role of rats as reservoirs of zoonotic diseases, the microbial diversity present in urban rat populations remains unexplored. in this study, we used targeted molecular assays to detect known bacterial, viral, and protozoan human pathogens and unbiased high-throughput sequencing to identify ...201425316698
direct detection of indirect transmission of streptobacillus moniliformis rat bite fever infection.we describe the evaluation of culture-negative synovial fluid from a 3-year-old boy by pcr and electrospray ionization followed by mass spectrometry (pcr/esi-ms). our patient developed a diffuse rash and fever with systemic signs and symptoms of sepsis, but four sets of blood cultures obtained prior to initiation of antibiotics were negative. after 1 week of illness, he developed right-knee swelling. analysis of synovial fluid was consistent with infection, but cultures of specimens obtained fol ...201424719439
septic arthritis secondary to rat bite fever: a challenging diagnostic course.we describe a challenging diagnostic course of a case of septic arthritis secondary to rat bite fever (streptobacillus moniliformis) in a 29-year-old man who presented with generalised malaise, polyarthralgia and bilateral palmoplantar rash.201424695665
streptobacillus hongkongensis sp. nov., isolated from patients with quinsy and septic arthritis, and emended descriptions of the genus streptobacillus and streptobacillus moniliformis.two bacterial strains, hku33(t) and hku34, were isolated in hong kong from the pus aspirated from the right peritonsillar abscess of a patient with quinsy and the left elbow joint fluid of another patient with tophaceous gout and left elbow septic arthritis, respectively. the bacteria were gram-stain-negative, non-motile, non-spore-forming, non-haemolytic pleomorphic bacilli. they grew best on columbia agar with 5 % defibrinated sheep blood in an anaerobic environment or aerobic environment with ...201424912824
an unusual tale of rat-bite fever endocarditis.a 49-year-old man presented to our department with an acute history of right leg tenderness, rash, swelling and fever. ct of the chest, abdomen and pelvis and a transoesophageal echocardiogram confirmed the diagnosis of mitral valve infective endocarditis with distal splenic emboli. positive blood cultures revealed the causative organism to be streptobacillus moniliformis. the patient was treated with high-dose antibiotics and had mitral valve replacement surgery.201425414213
notes from the field: fatal rat-bite fever in a child - san diego county, california, 2013.in august 2013, the county of san diego health and human services agency was notified of a fatal case of rat-bite fever (rbf) in a previously healthy male, aged 10 years, who owned pet rats. two days before his death, the patient experienced rigors, fevers, vomiting, headaches, and leg pains. his physician noted a fever of 102.6°f (39.2ºc), documented a normal examination, diagnosed viral gastroenteritis, and prescribed anti-nausea medication. during the next 24 hours, the patient experienced vo ...201425522092
a teenager with fever, rash, and arthralgia. streptobacillus moniliformis infection. 201425436846
oh rats! fever, rash and arthritis in a young woman.a 17-year-old girl presented with worsening right-sided hip and low back pain for 2 days. she had also experienced intermittent fevers and a recurring maculopapular rash over the past 2 weeks. social history revealed the presence of three domestic rats living in the girl's home. blood cultures returned positive for streptobacillus moniliformis, the causative agent of rat-bite fever. rat-bite fever often goes undiagnosed, as the clinical presentation is non-specific. untreated, the infection can ...201526701936
streptobacillus notomytis sp. nov., isolated from a spinifex hopping mouse (notomys alexis thomas, 1922), and emended description of streptobacillus levaditi et al. 1925, eisenberg et al. 2015 emend.a pleomorphic, gram-negative, rod-shaped, indole-, oxidase- and catalase-negative, non-spore-forming, non-motile bacterium was isolated in 1979 from the heart of a spinifex hopping mouse (notomys alexis thomas, 1922) with septicaemia and stored as streptobacillus moniliformis in the strain collection of the animal health laboratory, south perth, western australia (ahl 370-1), as well as under ccug 12425. on the basis of 16srrna gene sequence analyses, the strain was assigned to the genus strepto ...201526438009
a japanese patient with a rare case of streptobacillus moniliformis bacteremia.streptobacillus moniliformis is the etiological agent of rat-bite fever, a rare disease in asia that is difficult to diagnose. we describe an elderly patient living in rat-infested conditions who presented with severe sepsis. he was successfully treated with meropenem, and blood culture revealed infection with s. moniliformis.201526344724
streptobacillus felis sp. nov., isolated from a cat with pneumonia, and emended descriptions of the genus streptobacillus and of streptobacillus moniliformis.a pleomorphic, gram-stain-negative, rod-shaped, indole-, oxidase- and catalase-negative, non-spore-forming, non-motile bacterium (strain 131000547(t)) was isolated from the lungs of a cat with pneumonia. on the basis of 16s rrna gene sequence analyses the strain was assigned to the genus streptobacillus with 97.6% sequence similarity to the type strain of streptobacillus moniliformis and 94.6% to that of streptobacillus hongkongensis. the clear differentiation of strain 131000547(t) from strepto ...201525858245
root sepsis associated with insect-dwelling sebaldella termitidis in a lesser dwarf lemur (cheirogaleus medius).sebaldella termitidis is a rare fastidious microorganism of the leptotrichiaceae family. a variety of closely related species are associated with severe and even life-threatening disease in humans and animals, such as streptobacillus moniliformis, the etiological organism of rat-bite fever as well as members of leptotrichia spp. and sneathia sanguinegens, which have been reported from cases of septicaemia. in contrast, since its description some 50 years ago, s. ermitidis has so far never been r ...201526377576
streptobacillus moniliformis endocarditis: case report and review of literature.rat bite fever is a rare infection and sometimes results in complications. this case report describes native mitral valve endocarditis in a 44-year-old male patient caused by streptobacillus moniliformis. the diagnosis was confirmed by transesophageal echocardiography and blood cultures (bactec). the patient was treated with iv crystalline penicillin (6 weeks) and gentamicin (2 weeks). the fundamental importance of a high index of suspicion, interpreting investigations and appropriateness of the ...201523993005
streptobacillus moniliformis bacteremia in a rheumatoid arthritis patient without a rat bite: a case report.rat bite fever is a relatively rare infectious disease due to infection with streptobacillus moniliformis or spirillum minus mainly via directs bite by rats, mice, or other rodents. if there is no clear bite history, the diagnosis is difficult or may not be made.201526584844
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