Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| first report of maconellicoccus hirsutus (green, 1908) (hemiptera: coccoidea: pseudococcidae) and the associated parasitoid anagyrus kamali moursi, 1948 (hymenoptera: encyrtidae), in brazil. | the pink hibiscus mealybug (phm), maconellicoccus hirsutus (green) (hemiptera: pseudococcidae) and the associated hymenopterous parasitoid, anagyrus kamali moursi, 1948 (hymenoptera: encyrtidae), are reported for the first time in brazil. specimens of the phm were collected on nine hosts plants, annona muricata l. (anonnaceae), glycine max (l.) merr. (fabaceae), centrolobium paraensis tul. (fabaceae), inga edulis mart. (fabaceae), hibiscus rosa-sinensis l. (malvaceae), psidium guajava l. (myrtac ... | 2013 | 23917571 |
| synergistic larvicidal effect and morphological alterations induced by ethanolic extracts of annona muricata and piper nigrum against the dengue fever vector aedes aegypti. | phytopesticide combinations of different botanical sources are seldom reported. annona muricata seed and piper nigrum fruit ethanolic extracts enriched in acetogenins and piperamides, respectively, were synergistically used as larvicides against the dengue fever vector aedes aegypti. | 2013 | 23112098 |
| in vitro anthelmintic activity of aqueous leaf extract of annona muricata l. (annonaceae) against haemonchus contortus from sheep. | despite the overall progress of sheep farming in brazil, infections with the gastrointestinal parasite haemonchus contortus represent one the most important problems in sheep production, aggravated by the increasing resistance of nematodes to traditional anthelmintic drugs caused by inadequate sheep flock management by breeders. ethnopharmacological data indicate annona muricata as a promising alternative for the control of gastrointestinal nematodes because of its general anthelmintic propertie ... | 2013 | 23583362 |
| different susceptibilities of leishmania spp. promastigotes to the annona muricata acetogenins annonacinone and corossolone, and the platymiscium floribundum coumarin scoparone. | leishmaniasis is a zoonotic disease that can manifest itself in visceral and cutaneous form. the aim of this study was to search for new leishmanicidal compounds. preliminarily, artemia salina assay was applied to compounds from two plants found in northeastern brazil, platymiscium floribundum and annona muricata. then these compounds were tested against three leishmania species (leishmania donovani, leishmania mexicana and leishmania major). a screening assay using luciferase-expressing promast ... | 2013 | 23232251 |
| [analysis of the microbiological quality and potential presence of listeria monocytogenes in custard apple (annona muricata), mango (mangifera indica) and passion fruit (passiflora edulis) pulps from costa rica]. | the objective of this work was to determine some of the indicators associated to shelf life, hygiene, process and storage conditions for some of custard apple, mango and passion fruit pulps distributed by the main supermarket chains of the metropolitan area of san josé, costa rica, as well as to examine the potential presence of listeria monocytogenes in them. sixty fruit pulp samples were analyzed. tests included ph determination, total aerobic plate count, yeasts and mold count, lactic bacteri ... | 2013 | 24167958 |
| effect of selected local medicinal plants on the asexual blood stage of chloroquine resistant plasmodium falciparum. | the development of resistant to current antimalarial drugs is a major challenge in achieving malaria elimination status in many countries. therefore there is a need for new antimalarial drugs. medicinal plants have always been the major source for the search of new antimalarial drugs. the aim of this study was to screen selected malaysian medicinal plants for their antiplasmodial properties. | 2014 | 25510573 |
| [survival of trypanosoma cruzi in experimentally contaminated drinks]. | trypanosoma cruzi is the causative agent of chagas disease, transmitted primarily by triatomine insects. however, in 2005, oral transmission was documented in countries where the disease is endemic for chagas disease. this trend may also occur in colombia, a situation that motivated epidemiological alerts and the necessity for exploring the risk level of oral, human-to-human infection by t. cruzi. | 2014 | 23235795 |
| the association between chromaticity, phenolics, carotenoids, and in vitro antioxidant activity of frozen fruit pulp in brazil: an application of chemometrics. | a total of 19 brazilian frozen pulps from the following fruits: açai (euterpe oleracea), blackberry (rubus sp.), cajá (spondias mombin), cashew (anacardium occidentale), cocoa (theobroma cacao), coconut (cocos nucifera), grape (vitis sp.), graviola (annona muricata), guava (psidium guajava), papaya (carica papaya), peach (prunus persica), pineapple (ananas comosus), pineapple and mint (a. comosus and mentha spicata), red fruits (rubus sp. and fragaria sp.), seriguela (spondias purpurea), strawbe ... | 2014 | 24547813 |
| quantification of bioactive compounds in pulps and by-products of tropical fruits from brazil. | this study aimed to quantify the levels of resveratrol, coumarin, and other bioactives in pulps and by-products of twelve tropical fruits from brazil obtained during pulp production process. pineapple, acerola, monbin, cashew apple, guava, soursop, papaya, mango, passion fruit, surinam cherry, sapodilla, and tamarind pulps were evaluated as well as their by-products (peel, pulp's leftovers, and seed). total phenolic, anthocyanins, yellow flavonoids, β-carotene and lycopene levels were also deter ... | 2014 | 24054258 |
| antiproliferative activity and induction of apoptosis by annona muricata (annonaceae) extract on human cancer cells. | annona muricata (a. muricata) is widely distributed in asia, africa and south america. different parts of this plant are used to treat several diseases in cameroon. the aim of this study is to determine the in vitro anti-proliferative effects and apoptotic events of a. muricata extracts on hl-60 cells as well as to quantify its phenols content. | 2014 | 25539720 |
| the antioxidant activity of soursop decreases the expression of a member of the nadph oxidase family. | cellular oxidative stress produced by an increase in free radicals is one of the factors that promote the development of chronic degenerative diseases; therefore, consuming natural antioxidants helps minimize their negative effects. this study evaluated the cytotoxicity of the soursop extract (annona muricata), its cytoprotective capacity against oxidative stress induced by hydrogen peroxide, the inhibitory potential of reactive oxygen species (ros), the molecular mechanism of its antioxidant ac ... | 2014 | 24337133 |
| antidiabetic and antioxidant effects of annona muricata (annonaceae), aqueous extract on streptozotocin-induced diabetic rats. | the leaves of annona muricata are used in cameroon to manage diabetes and its complications. the aim of this study was to evaluate the antidiabetic, antioxidant activities and the potential toxicity of aqueous extract of annona muricata in streptozotocin-induced diabetic rats. | 2014 | 24076471 |
| gastroprotective activity of annona muricata leaves against ethanol-induced gastric injury in rats via hsp70/bax involvement. | the popular fruit tree of annona muricata l. (annonaceae), known as soursop and graviola, is a widely distributed plant in central and south america and tropical countries. leaves of a. muricata have been reported to possess antioxidant and anti-inflammatory activities. in this study, the gastroprotective effects of ethyl acetate extract of a. muricata leaves (eeam) were investigated against ethanol-induced gastric injury models in rats. the acute toxicity test of eeam in rats, carried out in tw ... | 2014 | 25378912 |
| phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of annona muricata (graviola). | to determine the phytochemical composition, antioxidant and anticancer activities of ethanolic and water leaves extracts of annona muricata (a. muricata) from the eastern uganda. | 2014 | 25312150 |
| annona muricata leaves induce g₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human hct-116 and ht-29 colon cancer cells. | annona muricata known as "the cancer killer" has been widely used in the traditional medicine for the treatment of cancer and tumors. the purpose of this study is to investigate the anticancer properties of ethyl acetate extract of annona muricata leaves (eeam) on ht-29 and hct-116 colon cancer cells and the underlying mechanisms. | 2014 | 25195082 |
| mechanisms of analgesic and anti-inflammatory properties of annona muricata linn. (annonaceae) fruit extract in rodents. | unripe fruit of annona muricata linn. (annonaceae) (soursop) is used in traditional african medicine for the treatment of neuralgia, rheumatism, and arthritic pain. this study sought to investigate the analgesic and anti-inflammatory effects of lyophilized fruit extract of annona muricata (am) in rodents. the analgesic activity was evaluated using the mouse writhing, formalin, and hot-plate tests while the anti-inflammatory action was investigated using the carrageenan-induced rat paw edema and ... | 2014 | 25133801 |
| annona muricata leaves induced apoptosis in a549 cells through mitochondrial-mediated pathway and involvement of nf-κb. | annona muricata leaves have been reported to have antiproliferative effects against various cancer cell lines. however, the detailed mechanism has yet to be defined. the current study was designed to evaluate the molecular mechanisms of a. muricata leaves ethyl acetate extract (ameae) against lung cancer a549 cells. | 2014 | 25127718 |
| an annotated checklist of scale insects (hemiptera: coccoidea) of saint lucia, lesser antilles . | an annotated list of 83 scale insect species (hemiptera: sterorrhyncha: coccoidea) recorded from saint lucia is presented, based on data gathered from uk quarantine interceptions, samples collected in an urban coastal habitat in the north west of the island in 2013, and published records. thirty-three species (40%) are recorded for the first time for the country, including dysmicoccus joannesiae (costa lima), a south american mealybug, and poliaspoides formosana (takahashi), an asian armoured sc ... | 2014 | 25112239 |
| effects of propylene glycol alginate and sucrose esters on the physicochemical properties of modified starch-stabilized beverage emulsions. | this study was conducted to investigate the effect of main emulsion components namely, modified starch, propylene glycol alginate (pga), sucrose laurate and sucrose stearate on creaming index, cloudiness, average droplet size and conductivity of soursop beverage emulsions. generally, the use of different emulsifiers or a mixture of emulsifiers has a significant (p < 0.05) effect on the response variables studied. the addition of pga had a significant (p < 0.05) effect on the creaming index at 55 ... | 2014 | 24962400 |
| effect of the application of 1-methylcyclopropene and wax emulsions on proximate analysis and some antioxidants of soursop (annona muricata l.). | the effect of the application of 1-methylcyclopropene (1-mcp) and wax emulsions, alone or combined, on composition analysis, vitamin c, polyphenols, and antioxidant capacity of soursop was evaluated. fruits were stored as follows: at 25 °c (control), and at 16 °c: fruits sprayed with candelilla or flava emulsions, fruits treated with 1500 nl/l of 1-mcp (20 °c, 12 h), and fruits treated with 1-mcp and then sprayed with emulsions. fruits were allowed to ripen and the edible part was used for analy ... | 2014 | 24892105 |
| three new anti-proliferative annonaceous acetogenins with mono-tetrahydrofuran ring from graviola fruit (annona muricata). | bioassay-guided fractionation of the fruit powder of graviola (annona muricata) yielded three novel compounds: muricins j, k, and l. the compounds are all c35 annonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. their structures were elucidated by spectral methods and chemical modification after isolation via chromatographic techniques and hplc purification. these three acetogenins demonstrated an antiproliferative against human prostate cancer pc-3 cells. | 2014 | 24780120 |
| the effect of prime emulsion components as a function of equilibrium headspace concentration of soursop flavor compounds. | perceptions of food products start when flavor compounds are released from foods, transported and appropriate senses in the oral and nose are triggered. however, the long-term stability of flavor compounds in food product has been a major concern in the food industry due to the complex interactions between key food ingredients (e.g., polysaccharides and proteins). hence, this study was conducted to formulate emulsion-based beverage using natural food emulsifiers and to understand the interaction ... | 2014 | 24708894 |
| influence of annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats. | to evaluate the effect of hydroalcoholic extract of a. muricata on biodistribution of two radiopharmaceuticals: sodium phytate and dimercaptosuccinic acid (dmsa), both labeled with 99mtechnetium. | 2014 | 24626725 |
| a systematic review of medicinal plants used for weight loss in brazil: is there potential for obesity treatment? | obesity is a pandemic disease and its prevalence is still increasing. moreover, it has important costs to public health. in brazil, many plants are used for weight loss by overweight or obese people, but there is a lack of scientific basis for this practice. many ethnobotanical studies aiming to characterize this usage have been published, but they are still limited by the region considered and the diversity of the popular knowledge. | 2015 | 26520790 |
| method development for quantification of the environmental neurotoxin annonacin in rat plasma by uplc-ms/ms and application to a pharmacokinetic study. | annonacin is an environmental neurotoxin identified in the pulp of several fruits of the annonaceae family (for example in annona muricata, asimina triloba), whose consumption was linked with the occurrence of sporadic atypical parkinsonism with dementia. pharmacokinetic parameters of this molecule are unknown. a method for its quantification in rat plasma was developed, using its analogue annonacinone as an internal standard. extraction from plasma was performed using ethylacetate with a good r ... | 2015 | 26444335 |
| in vitro protective potentials of annona muricata leaf extracts against sodium arsenite-induced toxicity. | sodium arsenite (naaso2) is a metalloid which is present widely in the environment and its chronic exposure can contribute to the induction of oxidative stress, resulting in disturbances in various metabolic functions including liver cell death. hence, there is a need to develop drugs from natural sources, which can reduce arsenic toxicity. while there have been reports regarding the antioxidant and protective potentials of annona muricataleaf extracts, our study is the first ofits kind to exten ... | 2015 | 26033234 |
| annona muricata leaves accelerate wound healing in rats via involvement of hsp70 and antioxidant defence. | annona muricata, a member of the annonaceae family, is commonly known as soursop and graviola. the leaves of this tropical fruit tree are widely used in folk medicine against skin diseases and abscesses, however there is no scientific evidence justifying the use of a. muricata leaves. the aim of the present study is to evaluate the wound healing potential of ethyl acetate extract of a. muricata leaves (eeam) towards excisional wound models in rats. | 2015 | 25899210 |
| synergistic interactions among flavonoids and acetogenins in graviola (annona muricata) leaves confer protection against prostate cancer. | phytochemical complexity of plant extracts may offer health-promoting benefits including chemotherapeutic and chemopreventive effects. isolation of 'most-active fraction' or single constituents from whole extracts may not only compromise the therapeutic efficacy but also render toxicity, thus emphasizing the importance of preserving the natural composition of whole extracts. the leaves of annona muricata, commonly known as graviola, are known to be rich in flavonoids, isoquinoline alkaloids and ... | 2015 | 25863125 |
| the chemopotential effect of annona muricata leaves against azoxymethane-induced colonic aberrant crypt foci in rats and the apoptotic effect of acetogenin annomuricin e in ht-29 cells: a bioassay-guided approach. | annona muricata has been used in folk medicine for the treatment of cancer and tumors. this study evaluated the chemopreventive properties of an ethyl acetate extract of a. muricata leaves (eeaml) on azoxymethane-induced colonic aberrant crypt foci (acf) in rats. moreover, the cytotoxic compound of eeaml (annomuricin e) was isolated, and its apoptosis-inducing effect was investigated against ht-29 colon cancer cell line using a bioassay-guided approach. this experiment was performed on five grou ... | 2015 | 25860620 |
| antioxidant, dna protective efficacy and hplc analysis of annona muricata (soursop) extracts. | annona muricata is a naturally occurring edible plant with wide array of therapeutic potentials. in india, it has a long history of traditional use in treating various ailments. the present investigation was carried out to characterize the phytochemicals present in the methanolic and aqueous leaf extracts of a. muricata, followed by validation of its radical scavenging and dna protection activities. the extracts were also analyzed for its total phenolic contents and subjected to hplc analysis to ... | 2015 | 25829616 |
| antiproliferative activity of aqueous leaf extract of annona muricata l. on the prostate, bph-1 cells, and some target genes. | annona muricata l. has been reported to possess antitumor and antiproliferative properties. not much work has been done on its effect on bph-1 cell lines, and no in vivo studies targeting the prostate organ exist. the study determined the effect of a muricata on human bph-1 cells and prostate organ. | 2015 | 25411208 |
| distribution of phenolic contents, antidiabetic potentials, antihypertensive properties, and antioxidative effects of soursop (annona muricata l.) fruit parts in vitro. | soursop fruit has been used in folklore for the management of type-2 diabetes and hypertension with limited information on the scientific backing. this study investigated the effects of aqueous extracts (1 : 100 w/v) of soursop fruit part (pericarp, pulp, and seed) on key enzymes linked to type-2 diabetes (α-amylase and α-glucosidase) and hypertension [angiotensin-i converting enzyme (ace)]. radicals scavenging and fe(2+) chelation abilities and reducing property as well as phenolic contents of ... | 2015 | 26788368 |
| an appraisal of eighteen commonly consumed edible plants as functional food based on their antioxidant and starch hydrolase inhibitory activities. | eighteen edible plants were assessed for their antioxidant potential based on oxygen radical absorbance capacity (orac), 2,2-diphenyl-1-picrylhydrazyl (dpph) radical scavenging activity, total phenolics, vitamin c content and various lipophilic antioxidants. the inhibitory activities of the plant extracts against the enzymatic activities of α-amylase and α-glucosidase were also evaluated. | 2015 | 25491037 |
| spectral and hrtem analyses of annona muricata leaf extract mediated silver nanoparticles and its larvicidal efficacy against three mosquito vectors anopheles stephensi, culex quinquefasciatus, and aedes aegypti. | mosquitoes transmit various diseases which mainly affect the human beings and every year cause millions of deaths globally. currently available chemical and synthetic mosquitocidal agents pose severe side effects, pollute the environment vigorously, and become resistance. there is an urgent need to identify and develop the cost effective, compatible and eco-friendly product for mosquito control. the present study was aimed to find out the larvicidal potential of aqueous crude extract and green s ... | 2015 | 26410042 |
| annona muricata leaf extract-mediated silver nanoparticles synthesis and its larvicidal potential against dengue, malaria and filariasis vector. | mosquitoes transmit several diseases which cause millions of deaths every year. the use of synthetic insecticides to control mosquitoes caused diverse effects to the environment, mammals, and high manufacturing cost. the present study was aimed to test the larvicidal activity of green synthesized silver nanoparticles using annona muricata plant leaf extract against third instar larvae of three medically important mosquitoes, i.e., aedes aegypti, anopheles stephensi, and culex quinquefasciatus. t ... | 2015 | 26002825 |
| annona muricata (annonaceae): a review of its traditional uses, isolated acetogenins and biological activities. | annona muricata is a member of the annonaceae family and is a fruit tree with a long history of traditional use. a. muricata, also known as soursop, graviola and guanabana, is an evergreen plant that is mostly distributed in tropical and subtropical regions of the world. the fruits of a. muricata are extensively used to prepare syrups, candies, beverages, ice creams and shakes. a wide array of ethnomedicinal activities is contributed to different parts of a. muricata, and indigenous communities ... | 2015 | 26184167 |
| stability, antimicrobial activity, and effect of nisin on the physico-chemical properties of fruit juices. | heat processing is the most commonly used hurdle for inactivating microorganisms in fruit juices. however, this preservation method could interfere with the organoleptic characteristics of the product. alternative methods have been proposed and bacteriocins such as nisin are potential candidates. however, the approval of bacteriocins as food additives is limited, especially in foods from vegetal origin. we aimed to verify the stability, the effect on physico-chemical properties, and the antimicr ... | 2015 | 26162590 |
| anti-microbial efficacy of soursop leaf extract (annona muricata) on oral pathogens: an in-vitro study. | annona muricata also called as soursop is a, flowering evergreen tree native to mexico, cuba, central america and parts of india. the miracle tree as it is widely known as a natural cancer killer that is 10,000 times stronger than chemotherapy. based on these miraculous claims, the leaves of these plants were used as an extract at varying concentrations as an antibacterial agent against oral pathogens. | 2016 | 28050493 |
| antibacterial activity of leaf extract of annona muricata and simarouba glauca on enterococcus faecalis. | to determine the antimicrobial effect of water extracts of leaves of annona muricata and simarouba glauca on enterococcus faecalis using agar diffusion method. | 2016 | 27659082 |
| identification of lactic acid bacteria in fruit pulp processing byproducts and potential probiotic properties of selected lactobacillus strains. | this study aimed to identify lactic acid bacteria (lab) in byproducts of fruit (malpighia glabra l., mangifera indica l., annona muricata l., and fragaria vesca l.) pulp processing. fifty strains of lab were identified using matrix-assisted laser desorption/ionization-time of flight mass spectrometry (maldi-tof ms) and 16s rrna gene sequence (16s rrna) analysis. species belonging to lactobacillus genus were the predominant lab in all fruit pulp processing byproducts. the average congruency betwe ... | 2016 | 27625647 |
| antibacterial activities of the methanol extracts of canarium schweinfurthii and four other cameroonian dietary plants against multi-drug resistant gram-negative bacteria. | bacterial infections are among the major cause of morbidity and mortality worldwide. the present study was designed to evaluate the in vitro antibacterial activities of the methanol extracts of five cameroonian edible plants namely colocasia esculenta, triumfetta pentandra, hibiscus esculentus, canarium schweinfurthii and annona muricata against a panel of 19 multidrug resistant gram-negative bacterial strains. the liquid broth microdilution was used to determine the minimal inhibitory concentra ... | 2016 | 27579004 |
| isolation and identification of biocellulose-producing bacterial strains from malaysian acidic fruits. | biocellulose (bc) is pure extracellular cellulose produced by several species of micro-organisms that has numerous applications in the food, biomedical and paper industries. however, the existing biocellulose-producing bacterial strain with high yield was limited. the aim of this study was to isolate and identify the potential biocellulose-producing bacterial isolates from malaysian acidic fruits. one hundred and ninety-three bacterial isolates were obtained from 19 local acidic fruits collected ... | 2016 | 27002476 |
| in vivo antimalarial activity of annona muricata leaf extract in mice infected with plasmodium berghei. | malaria is one of the most important infectious diseases in the world. the choice for the treatment is highly limited due to drug resistance. hence, finding the new compounds to treat malaria is urgently needed. the present study was attempted to evaluate the antimalarial activity of the annona muricata aqueous leaf extract in plasmodium berghei infected mice. aqueous leaf extract of a. muricata was prepared and tested for acute toxicity in mice. for efficacy test in vivo, standard 4-day suppres ... | 2016 | 27092277 |
| beneficial effect of medicinal plants on the contractility of post-hypoxic isolated guinea pig atria - potential implications for the treatment of ischemic-reperfusion injury. | context ischemic-reperfusion injury is accompanied by a decreased contractility of the myocardium. positive-inotropic agents have proven useful for treating this condition but may exert serious side-effects. objective in this study, aqueous preparations from abelmoschus esculentus l. moench (malvaceae), annona muricata l. (annonaceae), bixa orellana l. (bixaceae), cecropia peltata l. (moraceae), erythrina fusca lour. (fabaceae), psidium guajava l. (myrtaceae) and terminalia catappa l. (combretac ... | 2016 | 26730936 |
| herbal remedies and functional foods used by cancer patients attending specialty oncology clinics in trinidad. | cancer is a major disease worldwide, and many patients use complementary and alternative treatments. the purpose of this study was to identify the herbal remedies and functional foods used as complementary medicine by prostate, breast and colorectal cancer patients at speciality care facilities in trinidad. we also sought to determine how patients rated the efficacy of these modalities compared with conventional treatment. | 2016 | 27769229 |
| thermal processing alters the chemical quality and sensory characteristics of sweetsop (annona squamosa l.) and soursop (annona muricata l.) pulp and nectar. | the objective of this study was to investigate the effect of thermal processing on the chemical quality and sensory characteristics of annona squamosa l. and annona muricata l. fruit pulps and nectar. the fruit pulps were pasteurized at 85 °c for 20 min and nectar prepared as per food safety and standards authority of india (fssai) specifications. the chemical composition of fresh and heated pulps of a. squamosa and a. muricata showed that compared to fresh, the chemical profile and sensory prof ... | 2016 | 26642109 |
| vortex- and co2 -gas-assisted liquid-liquid microextraction with salt addition for the high-performance liquid chromatographic determination of furanic compounds in concentrated juices and dried fruits. | a novel microextraction method based on vortex- and co2 -assisted liquid-liquid microextraction with salt addition for the isolation of furanic compounds (5-hydroxymethyl-2-furaldehyde, 5-methyl-2-furaldehyde, 2-furaldehyde, 3-furaldehyde, 2-furoic and 3-furoic acids) was developed. purging the sample with co2 was applied after vortexing to enhance the phase separation and mass transfer of the analytes. the optimum extraction conditions were: extraction solvent (volume), propyl acetate (125 μl); ... | 2016 | 26718308 |
| chronic consumption of annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild-type and mapt transgenic mice. | in the pathogenesis of tauopathies, genetic and environmental factors have been identified. while familial clustering led to the identification of mutations in mapt encoding the microtubule-associated protein tau, the high incidence of a sporadic tauopathy endemic in guadeloupe was linked to the plant-derived mitochondrial complex i inhibitor annonacin. the interaction of both factors was studied in the present work in a realistic paradigm over a period of 12 months. mice over-expressing either ... | 2016 | 27569447 |
| anti-cancer effect of annona muricata linn leaves crude extract (amce) on breast cancer cell line. | annona muricata linn which comes from annonaceae family possesses many therapeutic benefits as reported in previous studies and to no surprise, it has been used in many cultures to treat various ailments including headaches, insomnia, and rheumatism to even treating cancer. however, annona muricata linn obtained from different cultivation area does not necessarily offer the same therapeutic effects towards breast cancer (in regards to its bioactive compound production). in this study, anti-proli ... | 2016 | 27558166 |
| polyketide natural products, acetogenins from graviola (annona muricata l), its biochemical, cytotoxic activity and various analyses through computational and bio-programming methods. | plants became the basis of traditional medicine system throughout the world for thousands of years and continue to provide mankind with new remedies. annona muricata, the plant of annonaceae family, is also known as sour sop or graviola. in recent years, many compounds have been reported and have gained organic chemist's and biochemist's attention because of their novel structure and wide range of bioactivity. local populations have used the bark, leaves, roots, fruit, seeds and flowers for thou ... | 2016 | 27262333 |
| functional proteomic analysis revels that the ethanol extract of annona muricata l. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway. | annona muricata l. is used to treat cancer in some countries. extracts of annona muricata have been shown to cause apoptosis of various cancer cells in vitro, and inhibit tumor growth in vivo in animal models. however, the molecular mechanisms underlying its anti-cancer and apoptotic effects of the herb remain to be explored. | 2016 | 27224241 |
| acetogenins from annona muricata as potential inhibitors of antiapoptotic proteins: a molecular modeling study. | apoptosis is a highly regulated process crucial for maintaining cellular homeostasis and development. the b-cell lymphoma 2 (bcl-2) family of proteins play a crucial role in regulating apoptosis. overexpressed bcl-2 proteins are associated with the development and progression of several human cancers. annona muricata is a tropical plant that belongs to the annonaceae family and is well known for its anticancer properties. in this study, molecular docking and simulations were performed to investi ... | 2016 | 27110097 |
| toxicology of a peruvian botanical remedy to support healthy liver function. | the purpose of these studies was to determine the safety of a botanical treatment for supporting healthy liver function developed in peru. the formulation, a4+, contains extracts of curcuma longa l. rhizome (a4r), cordia lutea lam. flower (a4f) and annona muricata l. leaf (a4l). the tests were used to support an application for a non-traditional natural health product licence from the natural health product directorate of health canada and future clinical trials. | 2016 | 27101557 |
| experimental lachesis muta rhombeata envenomation and effects of soursop (annona muricata) as natural antivenom. | in the atlantic forest of the north and northeast regions of brazil, local population often uses the fruit juice and the aqueous extract of leaves of soursop (annona muricata l.) to treat lachesis muta rhombeata envenomation. envenomation is a relevant health issue in these areas, especially due to its severity and because the production and distribution of antivenom is limited in these regions. the aim of the present study was to evaluate the relevance of the use of soursop leaf extract and its ... | 2016 | 26957955 |
| immunomodulatory efficacy of standardized annona muricata (graviola) leaf extract via activation of mitogen-activated protein kinase pathways in raw 264.7 macrophages. | annona muricata, commonly known as graviola, has been utilized as a traditional medicine to treat various human diseases. the aim of this study was to examine the immune-enhancing activity of graviola leaf extracts in raw 264.7 macrophage cells. active ingredients in graviola leaf extracts (ge) were identified as kaempferol-3-o-rutinoside and quercetin-3-o-rutinoside by lc-ms/ms. when treated with steam or 50% ethanol ge, cell morphology was altered due to initiation of cell differentiation. whi ... | 2016 | 28096884 |
| antiallergic effect of the atomized extract of rhizome of curcuma longa, flowers of cordia lutea and leaves of annona muricata. | allergies are a problem that greatly affects the population, and hence the use of antiallergic medications is fairly widespread. however, these drugs have many adverse effects. the use of medicinal plants could be an option, but they need to be evaluated. | 2016 | 27877047 |
| valorization of soursop flowers (annona muricata l.) as potent source of natural antioxidants for stabilization of palm olein during accelerated storage. | this study investigates the effect of soursop flowers methanolic extract on the physicochemical characteristics of palm olein during accelerated storage. after analysis of the extract by determining its total phenolic content by colorimetry and identification of some of its phenolic antioxidants by hplc-dad(diode array detector), preliminary antioxidants tests have been done. after that, the extract was added in palm olein at concentrations 200-1800 ppm. bht, at 200 ppm served as standard beside ... | 2016 | 27826429 |
| cytotoxicity of methanol extracts of annona muricata, passiflora edulis and nine other cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines. | cancer cells rapidly acquire resistance leading to treatment failures. in the present study, we have evaluated the cytotoxicity of 17 methanol extracts from 11 cameroonian medicinal plants against the sensitive leukemia ccrf-cem cells and the best ones were further tested on a panel of 8 other human cancer cell lines, including various mdr phenotypes as well as against the normal aml12 hepatocytes. | 2016 | 27730025 |
| neurotoxicity of dietary supplements from annonaceae species. | dietary supplements containing plant materials of annonaceae species (annona muricata l., a. squamosa l., a. mucosa jacq., a. squamosa × cherimola mabb.) were extracted by hot, pressurized ethyl acetate and analyzed for their effect in vitro on lund human mesencephalic neurons. cell viability was measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and cell death was determined by lactate dehydrogenase levels. three supplements strongly decreased the cell viability ... | 2016 | 26405269 |
| isolation of three new annonaceous acetogenins from graviola fruit (annona muricata) and their anti-proliferation on human prostate cancer cell pc-3. | bioassay-guided fractionation of the fruit powder of graviola (annona muricata) was continued to be conducted and yielded three more novel bioactive compounds: c-35 annonaceous acetogenins, muricins m and n, and c-37 annonaceous acetogenins, muricenin. they all contain a mono-tetrahydrofuran ring and four hydroxyl groups. the structures were elucidated by spectral methods and chemical modification after isolation via open column chromatographic separation and hplc purification. especially, muric ... | 2016 | 27499453 |
| application of the quechers method for the determination of organochlorine pesticide residues in brazilian fruit pulps by gc-ecd. | the quick, easy, cheap, effective, rugged, and safe (quechers) method was applied to the extraction of 14 organochlorine pesticides (ocps) residues from commercial fruit pulps available in supermarkets in fortaleza, northeastern brazil. the analyses were carried out by gas chromatography (gc), coupled to an electron-capture detector (ecd), and were confirmed by gc-tandem mass spectrometry (ms). the parameters of the analytical method, such as accuracy, precision, linear range, limits of detectio ... | 2017 | 27726598 |
| (1) h qnmr quantification of annonaceous acetogenins in crude extracts of annona muricata l. fruit pulp. | annonaceous acetogenins (aags) constitute a group of environmental neurotoxins, possibly implicated in sporadic atypical parkinsonism/dementia complexes. the recent evidencing of complex mixtures of aags in edible fruits and derived food products requires efficient and practical analytical tools for an estimation of human exposure. | 2017 | 28092423 |
| influence of different extraction conditions on antioxidant properties of soursop peel. | soursop is a healthy fruit. peels form about 20% of the soursop fruit and are usually discarded as waste product. with a view to utilizing soursop peel as a source of valuable compounds, this study aimed to investigate the influence of different extraction conditions on total phenolic content (tpc) and antioxidant capacity (ac) of soursop (annona muricata l.) peel. | 2017 | 28071019 |
| exploratory studies on the in vitro anti-inflammatory potential of two herbal teas (annona muricata l. and jasminum grandiflorum l.), and relation with their phenolic composition. | the need of new anti-inflammatory drugs has led to the search for safer and more potent molecules in distinct sources, such as natural products. this work aimed to explore the anti-inflammatory potential of aqueous extracts from two herbal teas (annona muricata l. and jasminum grandiflorum l.) in raw 264.7 macrophages cells and in cell-free assays. furthermore, the phenolic composition of both extracts and of their hydrolysates was characterized by hplc-dad, in order to establish possible relati ... | 2017 | 28256049 |
| antinociceptive and antihyperalgesic activity of a traditional maya herbal preparation composed of pouteria campechiana, chrysophyllum cainito, citrus limonum, and annona muricata. | preclinical research the purpose of this work was to assess the antinociceptive and antihyperalgesic properties of an herbal preparation, composed of four vegetal species: pouteria campechiana (p. campechiana), chrysophyllum cainito (c. cainito), citrus limonum (c. limonum), and annona muricata (a. muricata), that is commonly used in combination (pcca) in traditional mayan medicine for the treatment of diabetes and pain. an ethanolic extract of pcca was prepared at a ratio of 1:1:1:1 for each pl ... | 2017 | 28176363 |
| evaluation of cytotoxicity of aqueous extract of graviola leaves on squamous cell carcinoma cell-25 cell lines by 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide assay and determination of percentage of cell inhibition at g2m phase of cell cycle by flow cytometry: an in vitro study. | malignancies constitute a wide variety of disorders having high mortality and morbidity rates. current protocols for management include surgical intervention, chemotherapy, and radiation which possess numerous adverse effects. many phytochemicals are available with anticancer properties similar to anticancer drugs. major benefit of these compounds is apparent lack of toxicity to normal tissues. graviola (botanical name: annona muricata) contain bioactive compound "annonaceous acetogenins" known ... | 2017 | 26681860 |