Publications

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observations on antiviral screening. 19654285592
investigations on interferon induced by statolon. 19654285373
effect of iododeoxyuridine on encephalomyocarditis virus. 19654286923
nature of the antiviral activity of statolon. 19654286924
nucleic acid-induced resistance to viral infection.takano, kouichi (chas. pfizer & co., inc., terre haute, ind.), joel warren, keith e. jensen, and alan l. neal. nucleic acid resistance to viral infection. j. bacteriol. 90:1542-1547. 1965.-administration of nonviral nucleic acids to mice increased their resistance to a subsequent infection with influenza or encephalomyocarditis viruses. injection of ribonucleic acid or deoxyribonucleic acid by peripheral routes did not modify susceptibility to intranasal infection. lung tissue extracts from anim ...19654285332
necrosis of the pancreas, parotid and lachrymal glands associated with encephalomyocarditis virus infection. 19654287144
isolation and activity of propionin a, an antiviral polypeptide from propionibacteria. 19654289463
peculiarities of virus multiplication in explants and monolayer cell cultures from immune mouse organs. 19654379437
the role of interferon in tick-borne encephalitis virus-infected l cells. iv. origin of insusceptibility of persistently infected l cells to the action of exogenous interferon. 19654379466
[new light on the mode of action of oral immunization]. 196514267524
the role of interferon in tick-borne encephalitis virus-infected l cells. i. acute infection. 196514299351
the induction of mutations in encephalomyocarditis virus with nitrous acid. 196514299357
the role of interferon in tick-borne encephalitis virus-infected l cells. ii. persistent infection. 196514299366
the intracellular site of formation of encephalomyocarditis virus ribonucleic acid. 196514304870
intracellular fate of mengo virus ribonucleic acid.homma, m. (the wistar institute, philadelphia, pa.), and a. f. graham. intracellular fate of mengo virus ribonucleic acid. j. bacteriol. 89:64-73. 1965.-p(32)-labeled, purified preparations of mengo virus adsorbed rapidly and irreversibly to l cells maintained in suspension cultures. at intervals after adsorption of labeled virus, the total ribonucleic acid (rna) of infected cells was extracted by a phenol technique. infectivity titrations on this rna showed that it retained its full biological ...196514255683
studies on emc viral rna synthesis and its localization in infected krebs ascites cells. 196514319717
a density mutant of encephalomyocarditis virus. 196514322748
studies on the biological properties and classification of sv4 virus. 196514323044
some properties of the encephalomyocarditis, columbia sk and mengo viruses. 196514328905
infection of escherichia coli k-12 with rna of encephalomyocarditis virus. 196514282021
sites of synthesis of encephalomyocarditis virus components in infected l-cells. 196514331701
studies on protein and nucleic acid metabolism in virus-infected mammalian cells. the formation of a virus-specific antigen in krebs ii ascites-tumour cells infected with encephalomyocarditis virus.1. krebs ii mouse ascites-tumour cells infected with encephalomyocarditis virus were found to contain, in addition to mature virus, a virus-specific protein antigen. an assay, based on the ability of this antigen to block the neutralization of purified virus by its specific antiserum, was developed. 2. this antigen was present both in the culture fluid 17 hr. after the infection of cells with virus and intracellularly, where its titre increased at a time when viral capsid protein was being synth ...196514348194
studies of three variants of mengo encephalomyelitis virus. 3. effect of overlay and polyanions of plaque size. 196514329134
insusceptibility of cell cultures to the action of exogenous interferon as the result of virus infection of the cells. 19664380469
activity of salicylates as inhibitors of virus replication in vitro and their mode of action. 19664381329
defective t particles of vesicular stomatitis virus. ii. biologic role in homologous interference. 19664288277
[spectrophotometric and column-chromatographic analysis of ribonucleic acid extracted from suspensions of the brains of mice infected with mm virus exposed to the action of heat]. 19664287543
[provocation of an infection through vaccination. x. prevention of viral infection provocation through oral immunization with inactivated virus during the incubation period]. 19664295196
factors controlling amino acid incorporation by ribosomes from krebs ii mouse ascites-tumour cells.1. a ribosome-cell sap system capable of supporting the incorporation of (14)c-labelled amino acids into protein has been prepared from krebs ii mouse ascites-tumour cells. the requirements of this system for optimum activity and response to added messenger rna have been investigated. one such system has been obtained for which amino acid incorporation is almost wholly dependent on the addition of suitable messenger rna. 2. ribosomes of widely different but predictable activities in the cell-fre ...19664287844
role of interferon during viremia. i. production of circulating interferon. 19664285558
[desoxyribonuclease i activity of the hepato-splenic and cerebral tissue of rats during experimental infection with encephalomyocarditis virus]. 19664291609
effect of interferon on polymerization of single-stranded and double-stranded mengovirus ribonucleic acid.gordon, irving (university of southern california, los angeles), sara s. chenault, douglas stevenson, and jean d. acton. effect of interferon on polymerization of single-stranded and double-stranded mengovirus ribonucleic acid. j. bacteriol. 91:1230-1238. 1966.-the effect of interferon on actinomycin-resistant mengovirus ribonucleic acid (rna) replication in l cells was investigated to determine whether defective or partially polymerized rna products were made and whether synthesis of any specif ...19664286447
[active and passive homologous and heterologous interference experiements with col. sk virus in mice]. 19664293172
role of interferon during viremia. ii. protective action of circulating interferon. 19664285559
pathogenicity of the m and e variants of the encephalomyocarditis (emc) virus. ii. lesions of the pancreas, parotid and lacrimal glands. 19664286132
[action of formaldehyde on the infectious character of mm virus and on its ribonucleic acid]. 19664292030
[anatomo-pathological and virological study of murine infection with encephalomyocarditis virus (columbia-sk strain) in otorhinolaryngology]. 19664297257
effect of interferon on the production and action of viral rna polymerase. 19664290527
enhancement and inhibition by anionic polymers of plaque development by a variant of mengo encephalomyelitis virus. 19664290666
effect of cortisone on activation of lysosomal enzymes resulting from mengovirus infection of l-929 cells. 19664285387
non-heritable interferon resistance in a fraction of virus populations. 19664286948
studies of relationship between mouse cytomegalovirus and interferon. 19664286949
the pathogenesis of experimental infections with encephalomyocarditis (emc) virus. 19664286251
pathogenicity of the m and e variants of the encephalomyocarditis (emc) virus. i. myocardiotropic and neurotropic properties. 19664285783
antiviral activity of ammonium picrate in mice. 19664285507
inhibition of mengo virus by interferon.gauntt, charles j. (the university of texas, austin), and royce z. lockart, jr. inhibition of mengo virus by interferon. j. bacteriol. 91:176-182. 1966.-the inhibition of mengo virus replication in l cells resulting from interferon was studied quantitatively. interferon was titrated on l cells with western equine encephalomyelitis (wee) virus as the challenge virus. one protective unit (pu) of interferon is the least amount of interferon which prevents cytopathic effects when a large multiplicit ...19664285530
properties of a virus-induced rna polymerase in ascites cells infected with encephalomyocarditis virus. 19664161759
symposium on replication of viral nucleic acids. 3. replication of mengovirus ribonucleic acid. 19664287031
replication of mengovirus. ii. general properties of the viral-induced ribonucleic acid polymerase.plagemann, peter g. w. (western reserve university, cleveland, ohio), and h. earle swim. replication of mengovirus. ii. general properties of the viral-induced ribonucleic acid polymerase. j. bacteriol. 91:2327-2332. 1966.-mengovirus induces the appearance of a ribonucleic acid (rna) polymerase activity in novikoff hepatoma cells which is readily distinguished from the deoxyribonucleic acid (dna)-dependent rna polymerase since it is not inhibited by actinomycin d or deoxyribonuclease, but is inh ...19664287586
impairment of emc viral infectivity by cell-associated ribonuclease. 19664287697
heterogeneous rna's occurring during the replication of western equine encephalomyelitis virus. 19664286764
differential effects of nucleoside analogs on l-cell macromolecular synthesis and virus growth. 19664288420
effects of cortisol on interferon production by mouse peritoneal leukocytes and spleen in vitro and in vivo. 19664288628
effect of 8-azaguanine on encephalomyocarditis virus multiplication. 19664288633
some nuclear-substituted derivatives of alpha-methyldopa. 19664291024
in vitro and in vivo antiviral action of an interferon-like substance induced by toxoplasma gondii. 19664289528
the loss of photosensitivity of proflavine-sensitized encephalomyocarditis virus on contact with nonsusceptible cells. 19664289828
effect of choline salicylates and some other analogues of salicylic acid on the replication of emc virus in vitro. 19664289220
electrophoretic separation of two plaque-type variants of encephalomyocarditis virus. 19664288088
characterization of the products formed by the rna polymerases of cells infected with encephalomyocarditis virus. 19664287898
virulence and immunogenicity in mice of airborne encephalomyocarditis viruses and their infectious nucleic acids. 19664288720
defined media and development of mammalian eggs in vitro. 19664290121
effect of temperature and relative humidity on survival of airborne columbia sk group viruses.three strains of the columbia sk (col-sk) group of viruses [mengo, maus elberfeld (me), and col-sk viruses] have been studied in the airborne state. all three strains were found to give identical aerosol decay patterns at 16 or 26 c, when held at the same relative humidity (rh). during the first 5 min of aerosol storage time at 16 c, virus inactivation was rh-dependent, with survival maximal at either high (greater than 80%) or low (less than 5%) rh. after 5 min at 16 c, further inactivation, re ...19664291235
[cerebrospinal fluid findings, clinical aspects and virus etiology in acute polyneuritis]. 19664293974
replication of mengovirus. i. effect on synthesis of macromolecules by host cell.plagemann, peter g. w. (western reserve university, cleveland, ohio), and h. earle swim. replication of mengovirus. i. effect on synthesis of macromolecules by host cell. j. bacteriol. 91:2317-2326. 1966.-the replication of mengovirus was studied in two strains of novikoff (rat) hepatoma cells propagated in vitro. the replicative cycle in both strains required 6.5 to 7 hr. infection resulted in a marked depression of ribonucleic acid (rna) and protein synthesis by strain n1s1-63. inhibition of r ...19664287585
sensitivity to, and production of interferon by three variants of mengo virus. 19674292852
isolation of a series of mengo virus variants differing in sensitivity to polyanions. 19674291974
statolon-induced resistance of mice to mengovirus.mice receiving statolon intraperitoneally were 1,000 times more resistant to intraperitoneal challenge with mengovirus than were untreated controls. protection was afforded when statolon was administered 1 day before or 1 day after intraperitoneal inoculation with the virus. no therapeutic effect was observed when treatment with statolon was delayed for 2 days or more after virus infection. exposure of mice to a simulated space cabin environment did not increase their susceptibility to the letha ...19674291957
observations on the assay of infectious viral ribonucleic acid: effects of dmso and deae-dextran. 19674290717
a sensitive assay for infectivity of mengovirus rna in l cells. 19674291297
influence of heavy water (d2o) on the multiplication of adeno and mengo virus. 19674294141
polyribosome patterns in emc-virus infected krebs-2 cells and cell extracts. 19674294862
interaction of encephalomyocarditis virus with ultraviolet-irradiated host cells.ultraviolet light (uv) impaired the capacity of l cells to support growth of encephalomyocarditis virus. the loss of capacity was partially restored by high multiplicity of infection (moi). this phenomenon was not due to an increased probability of an infectious virus particle reaching a site of replication undamaged by uv, since uv-inactivated virus at high moi induced restoration of the capacity to support multiplication of nonirradiated virus adsorbed at low moi. multiplicity reactivation of ...19674318958
distribution of cell receptors and simple sugar inhibitors during encephalomyocarditis virus-cell union.encephalomyocarditis (emc) virus was studied for ability to agglutinate erythrocytes of various species. human, rat, and guinea pig erythrocytes, as well as those from young rabbits, were readily agglutinated. cells from older rabbits absorbed virus poorly, and showed little agglutination. uptake of virus by rabbit brain also diminished with age. various mouse tissues absorbed virus about equally well. hemagglutination-inhibition studies demonstrated that a number of simple sugars, particularly ...19674318947
[the effect of protein synthesis inhibitors on hemagglutinin formation and on cell destruction after infection with encephalomyocarditis virus]. 19674311448
effect of polycations on growth and dissemination of the encephalomyocarditis virus in mice.pathogenicity of the encephalomyocarditis (emc) virus for adult mice was increased when polycations of diverse type were mixed with virus and inoculated by the subcutaneous or intraperitoneal routes. diethylaminoethyl (deae) dextran, hexadimethrine (polybrene), polymyxin b, polylysine, and calf thymus histone in various concentrations stimulated multiplication of virus in tissues at the injection site and enhanced entry of virus into the blood. the nonpathogenic r(+) variant of emc which grows l ...19674316242
separation of plaque-type variants of encephalomyocarditis virus by chromatography on calcium phosphate.encephalomyocarditis (emc) virus (k-2 strain) was separated into two distinct peaks of optical density by chromatography on calcium phosphate, eluting at 0.17 and 0.31 m, respectively. the virus in these peaks could not be distinguished by infectivity (plaque-forming units), hemagglutinin activity, electron microscopic appearance, sedimentation coefficient, or base ratios. however, variants producing large plaques predominated in the first peak eluted, whereas variants producing small plaques we ...19674318950
passage of mengovirus through the zona pellucida of the mouse morula. 19674291335
incompetent relationship between coxsackievirus a6 ribonucleic acid and mouse cells. 19674290946
inhibition of rna synthesis in hela and l cells by mengovirus. 19674163399
use of kieselguhr to increase cell production for animal virus investigations. 19674291702
non-transfer of rna from parent to progeny of encephalomyocarditis virus. 19674291690
cytopathology of mengovirus infection. i. relationship between cellular disintegration and virulence. 19674290639
intrinsic interference: a unique interference system used in assaying non-cytopathic viruses. 19674301198
[the effect of protein synthesis inhibitor on krebs ii cells infected with emc virus]. 19674301378
cytopathology of mengovirus infection. ii. proliferation of membranous cisternae. 19674290640
studies of three variants of mengo encephalomyelitis virus. iv. affinities for mouse tissues in vitro and in vivo. 19674290510
thrombocytopenia in guinea pigs infected by encephalomyocarditis virus (emc). 19674298110
factors modifying host resistance to viral infection. i. effect of immunosuppressive drugs on experimental infection of mice with encephalomyocarditis virus. 19674299356
[characterization of various representatives of the columbia-sk-virus group with fluorescent antibodies. i. the reproduction cycle of mengo virus in l cells]. 19674299732
physico-chemical studies of three variants of mengo virus and their constituent ribonucleates. 19674292199
efficient, inefficient, and abortive infection of different mammalian cells by small rna viruses. 19674292343
an interferon antagonist: its effect on interferon action in mengo-infected ehrlich ascites tumor cells. 19674292344
polyribosomes in normal krebs 2 ascites tumor cells and in cells infected with encephalomyocarditis virus. 19674292778
chemical fractionation of antiviral plants. 19674292801
polycation effect on virulence of nonpathogenic r+ variant of the encephalomyocarditis virus. 19674292805
protein components of encephalomyocarditis virus. 19674293417
encephalomyocarditis virus infections in florida, 1960-1966. 19674293832
comparative growth and selection of small plaque and large plaque encephalomyocarditis virus in the absence of inhibitors from agar. 19674293935
the mutability of small-plaque-forming encephalomyocarditis virus. 19674293936
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