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properties of a murine sarcoma virus. 19705538357
[demonstration of bicatenar rna in a cellular line transformed and chronically infected by murine sarcoma virus]. 19704987723
aspects of harvey murine sarcoma virus complex. 19704376364
neoplastic bone lesions induced in rats and hamsters by moloney and harvey murine sarcoma viruses. 19704376388
acceleration by thymosin of the development of resistance to murine sarcoma virus-induced tumor in mice.the development of resistance to progressive tumor growth and the effect of a thymic extract upon this developmental process were examined in cba/wh mice. inoculating mice of various ages with murine sarcoma virus (moloney) permitted the assessment of the period of time postnatally at which the animals developed a threshold level of resistance to progressive tumor growth. resistance in cba/wh mice, at the virus dose used, was first detected at approximately two weeks of age and was completely de ...19705273447
antigenic properties of a nonreleaser neoplasm induced in the mouse by murine sarcoma virus. 197011515430
immunosuppression by murine sarcoma virus (moloney).infection of mice with the murine sarcoma virus (moloney) markedly suppressed the humoral antibody response to sheep erythrocyte antigen injected 10 days after infection, when tumor size was maximal, and on day 26, when primary tumors had partially regressed. humoral antibody response was also inhibited when antigen was injected at the time secondary tumors and metastases were evident. no significant suppression of humoral antibody was seen when mice were injected with sheep erythrocyte antigen ...197016557730
pathologic and virologic studies of tumors induced in mice by two strains of murine sarcoma virus. 197011515450
carcinogenesis by rna sarcoma viruses. xiv. infection of stationary cultures with murine sarcoma virus (harvey). 19704318031
viral interference in feline leukemia-sarcoma complex.feline leukemia viruses replicate in feline embryo fibroblast cultures without causing visible effects. the virus-infected cultures acquire a resistance to superinfection with the closely related focus-forming feline leukemia pseudotypes of murine sarcoma virus and the feline sarcoma viruses. this induction of viral interference in tissue cultures with the cell-transforming effects of the challenge viruses can be used as a quantitative in vitro assay for the detection of feline leukemia viruses. ...197118619364
rescue of murine sarcoma virus genome in mixed cultures of 'non-producer' hamster tumour cells and helper virus carrier cell lines. 19715542485
inhibition of murine sarcoma virus oncogenesis with living bcg. 19714943924
comparative pathology and ultrastructure of rodent sarcomas induced by the murine sarcoma virus (moloney). 19715091659
recovery of moloney murine sarcoma virus added to bovine milk. 19715101994
interference of daunomycin and adriamycin on the growth and aggression of murine sarcoma virus (moloney) tumors in mice. 19715120294
[resistance of akr mice to the oncogenic action of moloney murine sarcoma virus]. 19715126159
quantitative interactions of feline leukaemia virus and its pseudotype of murine sarcoma virus in cat cells: requirement for dna synthesis. 19715157829
studies on murine sarcoma virus. ii. detection of group-specific antigens by immunofluorescence. 19714993663
[action of actinomycin d on cell conversion induced by the murine sarcoma virus, moloney isolate]. 19714997223
potentiation of murine sarcoma virus (harvey) (moloney) oncogenicity in lactic dehydrogenase-elevating virus-infected mice. 19715554478
ultrastructure of giant cells in tumours induced in golden hamsters by murine sarcoma virus-harvey. 19715559595
the age related responses of new zealand mice to a murine sarcoma virus. 19715576664
glycopeptides from the surface of control and virus-transformed cells.glycopeptides were removed by trypsin digestion from the surface of control cells and cells transformed by rous sarcoma virus, murine sarcoma virus, or polyoma virus. after digestion with pronase, the glycopeptides were analyzed by gel filtration. the elution profiles suggest that there are differences in the glycopeptides from the surface of control cells and those from transformed cells.19714323250
retention of antigen specificity of murine sarcoma viruses grown in hamster cells in vitro. 19714324572
in vivo enhancement of a murine sarcoma virus by diethylaminoethyl-dextran. 19714325778
cellular interactions in vitro with cells derived from tumors induced by murine sarcoma virus (harvey). 19714325932
transformation of mouse 3t3 cells by murine sarcoma virus: release of virus-like particles in the absence of replicating murine leukemia helper virus.small numbers of virus-like particles were observed by electron microscopy in each of two cloned lines of 3t3 cells transformed by murine sarcoma virus, even though these lines were free of detectable quantities of infectious leukemia and sarcoma virus. the morphology and occurrence of the particles were identical to those of the murine leukemia-sarcoma group. moreover, the particles incorporated uridine and had a buoyant density of 1.16 g/ml in sucrose gradients. no evidence of sarcoma or leuke ...19714327005
nucleic acid and proteins isolated from a strain of murine sarcoma virus (msv-o). 19714327113
the effects of oronasal administration of two strains of murine sarcoma virus in mice. 19714330220
lack of requirement of murine leukemia virus for early steps in infection of mouse embryo cells by murine sarcoma virus. 19714331113
cytoplasmic dna synthesis induced by rna tumor viruses.infection of mouse embryo cells with two strains of murine sarcoma virus and one strain of murine leukemia virus was followed rapidly by synthesis of dna in the cytoplasm. persistently infected cells have not shown such synthesis, and ultraviolet-irradiated virus did not induce dna synthesis. this new dna presumably represents an intermediate in the virus replication cycle specified by the virion dna polymerase(s). failure to observe cytoplasmic dna synthesis in persistently infected cells sugge ...19714331562
the kinetics of rescue of the murine sarcoma virus genome from a nonproducer line of transformed mouse cells. 19714331729
chemical induction of focus-forming virus from nonproducer cells transformed by murine sarcoma virus.focus-forming virus can be induced by chemicals from virus-negative clonal lines of cells transformed by murine sarcoma virus. the viruses activated from such nonproducer cells have the host range and serologic properties of endogenous helper viruses of the cells rather than those of the sarcoma virus used to transform them. the evidence indicates that murine sarcoma virus-transformed nonproducer cells of two species contain the genetic information for both murine sarcoma and helper virus produc ...19714332005
rescue of murine sarcoma virus from a sarcoma-positive leukemia-negative cell line: requirement for replicating leukemia virus.the nature of murine sarcoma virus (msv) "defectiveness" was investigated by employing an msv-transformed mouse 3t3 cell line which releases noninfectious virus-like particles. rescue kinetics of msv, observed after murine leukemia virus (mulv) superinfection of these "sarcoma-positive leukemia-negative (s + l -)" mouse 3t3 cells, consisted of a 9- to 12-hr eclipse period followed by simultaneous release of both msv and mulv with no evidence for release of infectious msv prior to the production ...19714332138
cell line derived from a murine sarcoma virus (moloney pseudotype)-induced tumor: cultural, antigenic, and virological properties.a cell line derived from a murine sarcoma virus (moloney pseudotype)-induced tumor has been established. it retains oncogenicity, releases both sarcoma and leukemia viruses, and has virus-induced cellular antigens.19714332935
clonal isolation of murine sarcoma virus (msv): characterization of virus produced from transformed cells. 19714332977
characterization of murine sarcoma virus (kirsten) transformation of mouse and human cells. 19714333712
demonstration of differences in murine sarcoma virus foci formed in mouse and rat cells under a soft agar overlay. 19714333721
immune complex diseases. i. pathological changes in the kidneys of balb-c mice neonatally infected with moloney leukaemogenic and murine sarcoma viruses. 19714333814
the murine sarcoma virus (msv). 19714333859
alterations in the susceptibility of cultured mouse cells to transformation by murine sarcoma virus (harvey). 19714107845
rifamycin derivatives strongly inhibiting rna leads to dna polymerase (reverse transcriptase) of murine sarcoma viruses. 19724114001
revertants of mouse cells transformed by murine sarcoma virus. i. characterization of flat and transformed sublines without a rescuable murine sarcoma virus. 19724117128
isolation of temperature-sensitive mutants of murine sarcoma virus.three separate murine sarcoma virus nonproducer cell lines have been isolated which are temperature sensitive for the maintenance of transformation. in each case, a viral rather than a cellular genetic mutation is the reason for the temperature-sensitive effect. superinfection of one of the mutants with murine leukemia virus overcomes the temperature-sensitive change in the transformed state.19724117345
major group-specific protein of rat type c viruses.the major internal protein of a rat type c virus pseudotype of murine sarcoma virus, msv(ralv), was purified by isoelectric focusing (pi = 8.6) and used to prepare antibody in guinea pigs. the protein was identified by its reaction with antisera reactive with the mammalian type c virus group-specific (gs) antigenic determinant, gs-3. the guinea pig antisera mainly contained species-specific (gs-1) antibody for reactions in gel diffusion with other type c viruses were limited to those of rat orig ...19724117346
expression of a new complement-fixing antigen reactive with murine sarcoma virus rat antiserum in rat cells transformed by polyoma virus. 19724334196
stimulation of dna synthesis and enhancement of murine sarcoma virus replication in mouse embryo cells by sv 40. 19724334773
ultraviolet inactivation of moloney leukaemia virus: relative target size required for virus replication and rescue of 'defective' murine sarcoma virus. 19724334784
age dependent resistance to polyoma and murine sarcoma viruses in mice. 19724334879
increased uptake of amino acids and 2-deoxy-d-glucose by virus-transformed cells in culture.transformed and nontransformed cells in tissue culture differ in their rate of uptake of certain nutrients, as determined by a polyester-coverslip technique. a 2.5- to 3.5-fold increased rate of uptake of alpha-aminoisobutyric acid, cycloleucine, and 2-deoxy-d-glucose was observed with polyoma virus-transformed baby hamster kidney (bhk) 21 cells and simian virus 40 (sv40)-transformed balb/3t3 (mouse fibroblast) cells, compared to their nontransformed counterparts. kinetic analysis suggested that ...19724335068
properties of a murine sarcoma virus isolated from a tumor arising in an nzw-nzb f 1 hybrid mouse. i. isolation and pathology of tumors induced in rodents. 19724335642
properties of a murine sarcoma virus isolated from a tumor arising in an nzw-nzb f 1 hybrid mouse. ii. physical and biological characteristics. 19724335643
deficiency of viral ribonucleic acid-dependent deoxyribonucleic acid polymerase in noninfectious virus-like particles released from murine sarcoma virus-transformed hamster cells.virions from hamster cells transformed by a new strain of murine sarcoma virus (msv) appear to represent a form of msv deficient in one or more of the viral components necessary for infectivity. both the noninfectious virions and the sarcoma virus-transformed cells, which have no detectable replicating leukemia helper virus of either murine or hamster origin, are deficient in viral-type ribonucleic acid (rna)-dependent deoxyribonucleic acid (dna) polymerase activity (i.e., reverse transcriptase ...19724335663
replication of radiation-induced murine leukemia virus in normal and transformed mouse cells.autonomous radiation-induced leukemia virus (radlv) replication could be detected in mouse 3t3 cells by the development of interference with murine sarcoma virus (msv), the appearance of covert helper activity for defective msv, and by the induction of cytopathic effect type foci in msv-transformed, leukemia virus-negative (s+l-) cells. a chronic infection of either 3t3 or s+l- cells with radlv could be established. both radlv infectivity and helper activity were demonstrated in the same peak at ...19724335664
co-infection of mouse spleen cells with murine sarcoma virus and guaroa virus.enhancement of tumor induction by oncornaviruses through a dual viral infection has been described by several investigators. the mechanism(s) of this enhancement has not as yet been determined. by using a murine sarcoma virus and a bunyawera group arbovirus (guaroa virus) in an in vitro system, evidence was obtained for enhancement of the oncogenic potential of the viruses by genetic interaction with the nononcogenic virus as well as the production of increased amounts of the oncogenic virus. th ...19724336016
[loss of cellular sensitivity to endogenous interferon induced with the murine sarcoma virus]. 19724336176
comparison of murine sarcoma viruses in nonproducer and s + l - -transformed cells.the biologic properties of murine sarcoma viruses in nonproducer and s(+)l(-) cells were compared. each virus was found to be genetically stable through at least two cycles of rescue and transmission to new cells. there was no evidence for production of a defective murine leukemia virus by s(+)l(-) cells. the results are most consistent with the hypothesis that the sarcoma genome in s(+)l(-) cells contains information for replication functions which the virus in nonproducer cells either lacks or ...19724336564
amantadine hydrochloride: inhibitory effect on murine sarcoma virus infection in cell cultures. 19724336828
the genome of rna tumor viruses contains polyadenylic acid sequences.the 70s genome of two rna tumor viruses, murine sarcoma virus and avian myeloblastosis virus, binds to millipore filters in buffer with high salt concentration and to glass fiber filters containing poly(u). these observations suggest that 70s rna contains adenylic acid-rich sequences. when digested by pancreatic rnase, 70s rna of murine sarcoma virus yielded poly(a) sequences that contain 91% adenylic acid. these poly(a) sequences sedimented as a relatively homogenous peak in sucrose gradients w ...19724337237
stress and murine sarcoma virus (moloney)-induced tumors. 19724337829
transformation of guinea pig embryo cells by a murine sarcoma virus. 19724337992
reversion of murine sarcoma virus transformed mouse cells: variants without a rescuable sarcoma virus.murine sarcoma virus transformed mouse 3t3 cells, which are negative for murine leukemia virus and which yield sarcoma virus after superinfection with murine leukenmia virus, spotaneously give rise to flat variants front which murine sarcoma virus can no longer be rescued. the revertants support leukemia viruis growth and show an enhanced sensitivity to murine sarcoma superinfection and, like normal cells, do not release rna-dependent dna polymerase activity. because revertants could be obtained ...19724338196
viral rna subunits in cells transformed by rna tumor viruses.single-stranded 35s and 20s viral rna species are synthesized in virus-producing mouse and rat cells transformed by the murine sarcoma virus. a transformed hamster cell line that does not produce virus synthesizes 35s, but not 20s viral rna.19724338254
3-cyclic amine derivatives of rifamycin: strong inhibitors of the dna polymerase activity of rna tumor viruses.derivatives of rifamycin-sv with substituted cyclic-amine side chains in position 3 of the ansa ring are strong inhibitors of rna-directed dna and dna-directed dna polymerase activity of rna tumor viruses of murine, feline, and avian origin. among 37 3-amine derivatives of rifamycin-sv that were tested, 29 3-cyclic amine derivatives were good inhibitors of the viral polymerases. especially active were 3-piperidyl derivatives of rifamycin-sv with cyclohexyl and cyclohexylalkyl substituents. deriv ...19724338589
gazdar strain of murine sarcoma virus. biologic and antigenic interactions with the heterologous hamster host. 19724339068
tumors and other lesions induced by murine sarcoma viruses. 19724339212
rescue of the genome of the defective murine sarcoma virus from a non-producer hamster tumor cell line, pm-1, with murine and feline leukemia viruses as helpers. 19724339414
correlation between murine sarcoma virus buoyant density, infectivity, and viral rna electrophoretic mobility. 19724342084
transformation of a rat epithelial-like cell line by murine sarcoma virus. 19724342614
retransformation of ts sv40 transformants by murine sarcoma virus at non-permissive temperature. 19724343945
effects of dibutyryl cyclic adenosine phosphate plus theophylline on murine sarcoma virus transformed non-producer cells. 19724345701
an anemia-inducing virus derived from tumors caused by murine sarcoma virus--moloney. 19724345969
immunobiological studies of tumors induced by murine sarcoma virus (kirsten). 19724333497
detection of some murine leukemia virus antigens in virus particles derived from 3t3 cells transformed only by murine sarcoma virus. 19724333569
immunologic and virologic studies of a nonproducer tumor induced by murine sarcoma virus (harvey). 19724347035
rescue of the murine sarcoma virus genome from non-producer cells by the rd-114 type c virus. 19724358036
cell-mediated reaction against tumors induced by oncornaviruses. i. kinetics and specificity of the immune response in murine sarcoma virus (msv)-induced tumors and transplanted lymphomas. 19724128690
enhancement and suppression of murine sarcoma virus induced tumors by polyriboinosinic-polyribocytidylic acid. 19725007472
lack of distinctive surface antigen on cells transformed by murine sarcoma virus.some murine sarcoma virus (msv)-transformed mouse 3t3 cells contain the msv genome in the absence of infectious helper murine leukemia virus (mulv) and msv production. these cells, designated s+l- (sarcoma positive, leukemia negative), were analyzed for the presence of a possible msv-determined membrane antigen by the mixed hemadsorption test and in vitro lymphocyte cytotoxicity assay. two different serological approaches were used: (a) isoantibody-free sera were obtained by immunizing with msv ...19725043415
synthetic rna and dna polynucleotides: in vivo and in vitro enhancement of oncogenesis by a murine sarcoma virus. 19725057579
hypogammaglobulinaemia and lipaemia initiated by the murine sarcoma virus (moloney) in rats. 19725081216
induction of rat osteosarcoma by inoculation of murine sarcoma virus into bone marrow. 19724505011
different neoplastic response of mice and rats to infection by murine sarcoma virus (moloney). 19724507708
establishment of a virus-persistent cell line and deviation of malignant cell clones from rat osteosarcoma induced by a murine sarcoma virus (moloney). 19724507709
antigenic properties of murine sarcoma virus-transformed balb-3t3 nonproducer cells.the isolation of clonal lines of murine sarcoma virus-transformed, non-producer balb/3t3 cells has provided a model system for determining whether rna tumor virus-transformed cells possess virus-specific transplantation antigens. msv nonproducer cells (k-234) were clonally derived from an inbred mouse cell line, balb/3t3. a parallel virus-producing cell line was obtained by infection of the msv nonproducer cells with rauscher leukemia virus. k-234 was much more tumorigenic than k-234(r). preimmu ...19724550769
studies on murine sarcoma virus. 3. synthesis of the viral antigens in cells of various species. 19724554131
enhanced growth of a murine coronavirus in transformed mouse cells.plaque formation by a59 virus, a murine coronavirus, was facilitated in al/n and balb mouse cells transformed by polyoma virus, simian virus 40, murine sarcoma virus, or mammary tumor virus. in these virus-transformed cells, a59 virus plaques were larger, they appeared earlier, and plaquing efficiencies were higher than in normal, untransformed cells. "spontaneously" transformed al/n cells behaved similarly to untransformed cells, whereas "spontaneously" transformed balb cells resembled virus-tr ...19724564284
effects of daunomycin and adriamycin on the murine sarcoma virus (moloney) in vitro. 19724647914
epithelial features of "nonproducer" balb-3t3 cells transformed by murine sarcoma virus. 19724650203
the effect of immunosuppression on oncogenesis by murine sarcoma virus. 19724672103
the identification of the 3'terminus of the 70 s rna of murine sarcoma virus (moloney). 197211946807
chemotherapeutic response of epithelial tumors produced by primary implantation of a nonproducer line of murine sarcoma virus-transformed balb 3t3 cells. 19734126380
senescent loss of resistance to murine sarcoma virus (moloney) in the mouse. 19734748428
in vitro cytotoxicity studies of murine sarcoma virus-induced immunity in mice. 19734762933
metyrapone-inhibited oncogenesis in mice inoculated with a murine sarcoma virus. 19734765394
in utero tumor induction by murine sarcoma virus (moloney) in the rat. i. biological characteristics. 19734791222
tumour regression and relapse in mice inoculated with murine sarcoma virus (moloney). 19734795193
prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice. 19734795530
growth-and density-dependent inhibition of deoxyglucose transport in balb 3t3 cells and its absence in cells transformed by murine sarcoma virus.the earliest measurable parameter that shows density-dependent inhibition is the uptake of [(3)h]deoxyglucose by balb 3t3 cells. the rate decreases even during the exponential phase of growth and reaches a minimum, about 8- to 10-times lower than maximum, as the culture approaches the saturation density. cells transformed by murine sarcoma virus fail to show either growth-dependent or density-dependent inhibition of deoxyglucose uptake. treatment with dibutyryl cyclic amp in the presence of theo ...19734365700
sugar effects on murine sarcoma virus transformation.transformation of nih swiss mouse fibroblasts by a murine sarcoma virus was influenced by the type of carbohydrate in the culture medium. exposure to d-mannose and 2-deoxy-d-glucose caused a reduction in the number of transformed colonies in vitro and tumor formation in vivo. this is a new type of interference in the transformation process, manifested also by the absence of the pronounced enhancement of hexose entry into transformed cells, characteristic of a sarcoma virus infection. the uptake ...19734514307
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