Publications

[genetic characterization of the zaliv terpeniya virus (ztv, bunyaviridae, phlebovirus, uukuniemi serogroup) strains isolated from the ticks ixodes (ceratixodes) uriae white, 1852, obligate parasites of the alcidae birds, in high latitudes of northern eurasia and the mosquitoes culex modestus ficalbi, 1889, in subtropics transcaucasus].	complete genome sequences were obtained for the leiv-13841ka (id genbank kf767463-65) and leiv-279az (id genbank kf767460-62) virus strains, which were classified as different strains of the zaliv terpeniya virus (ztv). leiv-13841ka was isolated from the ticks ixodes (ceratixodes) uriae white, 1852 collected on ariy kamen (commander islands) in 1986. leiv-279az was isolated from the mosquitoes culex modestus ficalbi, 1889, collected in heron colony (ardea linnaeus, 1758) in azerbaijan (1969) and ...	2016	25065140
differential use of the c-type lectins l-sign and dc-sign for phlebovirus endocytosis.	bunyaviruses represent a growing threat to humans and livestock globally. the receptors, cellular factors and endocytic pathways used by these emerging pathogens to infect cells remain largely unidentified and poorly characterized. dc-sign is a c-type lectin highly expressed on dermal dendritic cells that has been found to act as an authentic entry receptor for many phleboviruses (bunyaviridae), including rift valley fever virus (rvfv), toscana virus (tosv) and uukuniemi virus (uukv). we found t ...	2016	26990254
rna encapsidation and packaging in the phleboviruses.	the bunyaviridae represents the largest family of segmented rna viruses, which infect a staggering diversity of plants, animals, and insects. within the family bunyaviridae, the phlebovirus genus includes several important human and animal pathogens, including rift valley fever virus (rvfv), severe fever with thrombocytopenia syndrome virus (sftsv), uukuniemi virus (uukv), and the sandfly fever viruses. the phleboviruses have small tripartite rna genomes that encode a repertoire of 5-7 proteins. ...	2016	27428993
electron microscopy of the uukuniemi virus, an ungrouped arbovirus.		2016	4871955
low ph and anionic lipid-dependent fusion of uukuniemi phlebovirus to liposomes.	many phleboviruses (family bunyaviridae) are emerging as medically important viruses. these viruses enter target cells by endocytosis and low ph-dependent membrane fusion in late endosomes. however, the necessary and sufficient factors for fusion have not been fully characterized. we have studied the minimal fusion requirements of a prototypic phlebovirus, uukuniemi virus, in an in vitro virus-liposome assay. we show that efficient lipid mixing between viral and liposome membranes requires close ...	2016	26811337
[genetic characterization of new komandory virus (komv; bunyaviridae, phlebovirus) isolated from the ticks ixodes uriae, collected in guillemot (uria aalge) nesting sites on komandorski islands, the bering sea].	unclassified virus named komandory virus (komv) isolated in komandorski islands from the ticks ixodes uriae in 1986 was partially sequenced. the komv nucleocapsid (n) protein sequence shows 30-40% identity level with the mosquito-borne phleboviruses and 43% with the uukuniemi virus (uukv) group (phlebovirus, bunyaviridae). the maximum identity (65%) for the komv n protein is observed for the manawa virus. the komv glycoprotein identity with the uukv group viruses ranges from 45% to 59%. the komv ...	2016	24772641
differential antagonism of human innate immune responses by tick-borne phlebovirus nonstructural proteins.	in recent years, several newly discovered tick-borne viruses causing a wide spectrum of diseases in humans have been ascribed to the phlebovirus genus of the bunyaviridae family. the nonstructural protein (nss) of bunyaviruses is the main virulence factor and interferon (ifn) antagonist. we studied the molecular mechanisms of ifn antagonism employed by the nss proteins of human apathogenic uukuniemi virus (uukv) and those of heartland virus (hrtv) and severe fever with thrombocytopenia syndrome ...	2017	28680969