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an evaluation of an adjuvant influenza virus vaccine tested against influenza b in 1954-1955. 195613372524
[virological and biological characteristics of influenza virus b isolated during 1955]. 195613392712
[severe bronchopneumopathy caused by apc virus with probable pneumococcal superinfection developing after influenza b virus infection]. 195613396602
[epidemiological observations in east hesse during influenza b epidemic in 1955]. 195713423631
enzymatic variants of influenza virus. i. isolation and characterization of slowly reacting enzymatic variants of influenza b virus.slowly reacting enzymatic variants of the lee strain of influenza b virus were isolated by the serial application of a technique which concentrated the fraction of the virus population obtained by slow elution followed by passage of this fraction at high dilution in chicken embryos. the variants were stable upon serial passage in chicken embryos and did not differ significantly from the parent virus in any of the characteristics tested other than those relating to the virus enzyme. enzymatically ...195713439115
studies on the enzymatic properties of influenza viruses. i. the action of influenza b virus and rde on the hemagglutinin inhibitor of human meconium. 195713443208
[homologous interference by heat-inactivated influenza-b-virus absorbed on erythrocytes]. 195713447900
[cleavage of n-acetyl-neuraminic acid from serum by influenza virus b (lee) and a-toxin of clostridium welchii]. 195713474661
the influence of cortisone on experimental viral infection. iil effects on certain dynamics of influenza virus increase.the administration of cortisone to chicken embryos infected with influenza b virus results in (a) an initial inhibition of viral synthesis and (b) an eventual increase in the final yield of virus attained. increased yields of virus are attained regardless of the number of viral particles in the infecting inoculum or the proportion of particles which are infective. changes in the distribution ratios of allantoic fluid and intramembrane virus are effected by cortisone only as the secondary result ...195713481248
the influence of cortisone on experimental viral infection. iv. negation of interference as the mechanism by which cortisone induces increased virus yields.the interference with viral synthesis which is induced by large quantities of non-infective influenza b virus is inhibited or negated with small quantities of cortisone and other c-21 steroids. the specificity of this effect is attested by the inactivity of 11-alpha hydroxy epimers of highly active compounds. maximal activity in negation of interference is associated with the presence of oxygen at the c-11 position of the steroid molecule. in view of the demonstration that negation of interferen ...195713481249
[antibody titers against influenza virus type b and against the far east strain of influenza virus in slovak inhabitants towards the end of 1957]. 195813585398
enzymatic variants of influenza virus. ii. effect of environmental factors on enzymatic characteristics of a variant of influenza b virus.the rate of elution of the variant virus from chicken rbc is progressively decreased as the temperature of incubation is increased above 25 degrees c. the activity of the parent virus, on the other hand, is increased as the temperature is increased up to 40 degrees c. the major cause of the decreased activity of the variant at temperatures above 2s degrees c. is an inhibition of the variant enzyme rather than its inactivation. the activity of the variant enzyme is stimulated in the presence of s ...195813587849
protective effect of seaweed extracts for chicken embryos infected with influenza b or mumps virus. 195813614432
development of resistance of influenza b virus to polysaccharides.algal polysaccharide obtained from carrageenin protects 80 to 100 percent of chicken embryos against fatal infections with the lee strain of influenza virus. this report describes the rapid emergence of a stable variant of this virus which is resistant to the protective action of this polysaccharide.195813615309
antibodies to asian influenza and influenza b: edinburgh, 1958. 195913629023
some new or little-known respiratory viruses.the characters and relationships of a number of viruses of potential importance in human respiratory diseases are reviewed. among the myxoviruses discussed are viruses related to influenza a (swine and horse influenza, british and czechoslovak duck influenza, fowl plague), influenza b and c, mumps and newcastle disease, and the para-influenzas. the echo viruses, 2060 and jh viruses, chimpanzee coryza agent and the common cold are also considered. in the final section of the paper the attempted t ...195913651924
[a new photometric technic for titration of the hemagglutination power of mixed viruses. i. influenza virus type b]. 195913663474
[basic properties of hemagglutination by influenza virus b]. 195913663475
comparison of the pathogenesis of newcastle disease virus and influenza b virus in chicken embryos. 196014425334
meningoencephalitis due to influenza virus b. 196014425918
[clinical aspects and therapy of influenza b during the period of the winter outbreak]. 196013682268
[evaluation of the preventive action of 1,1-(3-oxapentamethylene)-biguanide in an outbreak of influenza b]. 196013690293
an outbreak of influenza b in panama. 196113696218
spectrum and characteristics of the virus inhibitory action of 2-(alpha-hydroxybenzyl)-benzimidazole.2-(alpha-hydroxybenzyl)-benzimidazole (hbb) inhibited the cytopathic effects of the following enteroviruses: polio 1 to 3; coxsackie a9; coxsackie b 1 to 6; and echo virus types 1 to 9, 11 to 21, and 24 to 27. the following enteroviruses were not inhibited: coxsackie a types 7, 11, 13, 16, and 18; and echo types 22, 23, and 28. other hbb-insusceptible viruses were: arbor b and c, reo 1 to 3; adeno 2 to 4; influenza b; para-influenza 2 and 3; mumps; herpes simplex, and vaccinia. hbb had no inacti ...196113725919
relationship between structure of benzimidazole derivatives and selective virus inhibitory activity. inhibition of poliovirus multiplication and cytopathic effects by 2-(alpha-hydroxybenzyl)-benzimidazole, and its 5-chloroderivative.the virus inhibitory activity and selectivity of certain benzimidazole, benzotriazole, and naphthimidazole derivatives were determined with influenza b and polio type 2 viruses. among the sixty-five compounds examined, several were highly active inhibitors of influenza b virus multiplication in the chorioallantoic membrane in vitro. the following compounds, listed in order of increasing inhibitory activity, were more than 100 times as active as benzimidazole: 5-(4'-toluenesulfonamido)-benzimidaz ...196113775109
[epidemic influenza b virus outbreak rampant this summer in tunisia]. 196113877830
similarity of outbreaks of asian influenza and influenza b. in a school community. 196119790398
myxovirus infections in acute laryngotracheobronchitis, toronto, 1961-62.virological investigations were undertaken on nasopharyngeal secretions from 186 children who were admitted to the hospital for sick children, toronto, with acute laryngotracheobronchitis between december 1961 and march 1962. patients who required tracheotomy for relief of respiratory obstruction were excluded from this series. myxoviruses which were isolated from 47 patients included the following antigenic types: 29 parainfluenza-1, four parainfluenza-2, five parainfluenza-3 and nine influenza ...196220327304
serial propagation of influenza b (lee) virus in a transmissible line of canine kidney cells.the serial propagation of influenza b (lee) virus has been demonstrated in a transmissible line of canine kidney cells, as evidenced by the presence of cytopathic effects and hemagglutinins in each of six consecutive tissue-culture passages, and by egg infectivity titers of 10-4.3 and 10-4.1 per 0.1 ml in 3rd and 5th tissue culture fluids, respectively.196213901412
influenza viruses, 1957-60.during the period 1957-60 large numbers of influenza a viruses were received at the world influenza centre from countries throughout the world. with one exception all the strains were antigenically closely related to the a2 viruses isolated early in the asian influenza epidemic, and strikingly different from the a1 strains of the previous decade. the a2 viruses were very uniform antigenically and in other in vitro characteristics such as insensitivity to the beta-inhibitor of agglutination. howe ...196220604108
[influenza b outbreaks in the ground self-defense force, january through march, 1961]. 196213915207
[influenza b and a2 epidemics in norway during the 1st months of 1961]. 196213952721
influenza b at fort yukon: report of an outbreak, 1961. 196214471738
serious respiratory tract illness as a result of asian influenza and influenza b infections in children. 196214484063
[studies on the influenza b epidemic in kyushu district, especially in kumamoto district, in the spring of 1961]. 196214493467
laboratory studies of influenza virus type b infections in children. 196314023650
acute respiratory infections in children: i. an intensive study of etiology in an open community.during a seven-month period from november 1960 to may 1961, 181 infants and children, hospitalized because of acute respiratory infections, were studied intensively to determine the responsible etiologic agents. forty-two per cent of the illnesses in this group appeared to be caused by bacterial agents, either primary or secondary to virus. parainfluenza viruses were identified as causes of laryngotracheobronchitis in nearly 50% of the cases. adenoviruses were also found to be important pathogen ...196320327546
myxoviruses associated with acute laryngotracheobronchitis in toronto, 1962-63.between november 1962 and march 1963, myxoviruses were isolated from 95 of 224 children (40.5%), most of whom were aged less than three years, who were admitted to the hospital for sick children, toronto, with acute laryngotracheobronchitis (tracheitis or croup). viral isolates included 87 strains of parainfluenza-1, five of parainfluenza-3, and three of influenza a2. an epidemic of influenza a2 afflicted toronto during march 1963, at which time this virus was isolated from tracheitis patients.m ...196314098888
strain specific complement-fixation differentiation of influenza b viruses isolated in tissue culture. 196314120357
influenza virus b as cause of acute croup syndrome. 196414067457
enzymatic variants of influenza virus. iii. function of neuraminidase in the viral growth cycle.padgett, billie l. (university of wisconsin, madison), and duard l. walker. enzymatic variants of influenza virus. iii. function of neuraminidase in the viral growth cycle. j. bacteriol. 87:363-369. 1964.-multiplication of a slowly reacting enzymatic variant of influenza b virus, strain lee, was compared with that of parent virus in ovo. at 35 c, although their final yields were equal, variant virus reached its peak concentration in the allantoic fluids later than parent virus. at 39 c, multipli ...196414151058
micro diffusion precipitin tests for enteroviruses and influenza b virus.middleton, g. k., jr. (bowman gray school of medicine, winston-salem, n.c.), h. g. cramblett, h. l. moffet, j. p. black, and h. shulenberger. micro diffusion precipitin tests for enteroviruses and influenza b virus. j. bacteriol. 87:1171-1176. 1964.-a simple micro precipitin gel diffusion test has been adapted to the study of viral antigens. as far as is known from a review of recent literature, this is the first use of the echo viruses in precipitin tests and the first attempt to demonstrate by ...19644959799
[on a rare case of hemolytic anemia autoimmune caused by influenza b virus]. 19654956440
surveys of respiratory virus antibodies in an arctic indian population.a study was undertaken to determine the etiological agents responsible for epidemics in a small and relatively isolated arctic community.three serological surveys were carried out over a four-year period employing complement fixation tests. clinical information from the resident nurse was also available.the results indicated that of the two clinical epidemics of "influenza" which occurred during the period of study one was due to influenza virus type a; the other was unidentified. however, influ ...19654284108
induction of partial specific heterotypic immunity in mice by a single infection with influenza a virus.schulman, jerome l. (cornell university medical college, new york, n.y.), and edwin d. kilbourne. induction of partial specific heterotypic immunity in mice by a single infection with influenza a virus. j. bacteriol. 89:170-174. 1965.-mice infected 4 weeks previously with influenza a virus were found to be partially immune when challenged with influenza a2 virus. this partial immunity was demonstrated by reduced titers of pulmonary virus, decreased mortality, and less extensive lung lesions. a s ...196514255658
properties of hemagglutinins of influenza virus type b. 196514304762
a twenty-one-year experience with antigenic variation among influenza b viruses. 196514265902
effects of amantadines on influenza b and measles virus infection in children. 19664862167
rapid diagnosis of influenza b with fluorescent antibody. 19665330471
isolation of a new antigenic type of influenza b virus. 19665938894
influenza b in the spring of 1965. 19665959041
[isolation of influenza virus b from the lung and brain of a patient dying of meningoencephalitis]. 19665998985
[biological diagnosis of influenza b. observations made during a recent influenza epidemic]. 19666010541
an epidemic of influenza b in the province of quebec in the spring of 1966: laboratory studies.laboratory studies of an influenza b epidemic in the province of quebec carried out during the spring of 1966 are described. during that period six influenza b strains were isolated. the isolated strains did not differ markedly from previous influenza b strains. the serological studies showed that this epidemic had spread over different parts of the province of quebec.the serological studies also showed that an isolated community, such as an armed forces camp, can exhibit an epidemiological patt ...19676019961
[successive outbreaks of influenza b and a in the same locality in the winter and spring of 1966]. 19676062639
the 1967 influenza b in the ussr. 19676077621
susceptibility of the domestic swine to influenza b virus. 19675625091
[identification and characteristics of 3 influenza b virus strains isolated in latium in january 1967]. 19675629705
myxovirus dissemination by air.myxoviruses including 150 strains of parainfluenza 1, 15 of parainfluenza 3 and five of influenza b virus were isolated from nasopharyngeal secretions obtained from 300 children less than 3 years of age who developed acute laryngotracheobronchitis during the preceding 48 hours. the patients were examined between october 1966 and january 1967, the peak monthly rate of virus isolation (67%) occurring during january. parainfluenza 1 virus was isolated from air obtained in the vicinity of one of 30 ...19674290621
viral oncolysis: increased immunogenicity of host cell antigen associated with influenza virus.a2g mice could be solidly immunized against the ehrlich ascites tumor by single intraperitoneal injections of homogenized and lyophilized tumor cells which had been infected with oncolytic strains of influenza a virus. similar homogenates from noninfected tumor cells were not immunogenic, even when mixed with egg-grown virus. the immunizing principle in viral oncolysates could not be separated from the oncolytic virus by differential centrifugation or adsorption to and elution from red cells. it ...19674290961
the 1967 outbreak of influenza b in the u.s.s. r. 19674163159
adsorption of mycoplasma pneumoniae to neuraminic acid receptors of various cells and possible role in virulence.monkey, rat, and chicken tracheal epithelial cells, as well as monkey, rat, guinea pig, and chicken erythrocytes, adsorbed firmly to colonies of mycoplasma pneumoniae and m. gallisepticum. colonies of m. pulmonis also adsorbed erythrocytes but with less avidity than m. pneumoniae or m. gallisepticum; unlike the latter organisms, m. pulmonis did not adsorb tracheal epithelial cells. colonies of m. orale type 1 and m. orale type 3 adsorbed only chicken red cells. other mycoplasma species tested, i ...19684183967
encephalopathy and fatty degeneration of the viscera in childhood: ii. report of a case with isolation of influenza b virus. 19684300792
numerical taxonomy and influenza b virus. 19685637731
[influenza a2 and influenza b in the netherlands from 1957 to 1966]. 19685663170
investigetion into the attenuation of influenza viruses by serial passage.for vaccination live viruses are better than dead ones, but live influenza vaccines are difficult to prepare. one influenza a(2) and two influenza b viruses were passed in series in embryonated eggs. at several stages of their passage they were inoculated into volunteers, and their effects assessed by virus isolations, antibody rises, and clinical reactions. the a(2) virus and one of the influenza b viruses, both of which had grown readily in embryonated eggs on first isolation, continued to ind ...19685697664
[properties of influenza virus b-1 moscow 1966]. 19685698874
[the epidemiologic effectiveness of anti-influenza vaccine during the period of an epidemic of influenza b in january-february 1967]. 19685733715
cytoplasmic inclusions and nuclear changes in cells infected with influenza-b viruses. 19684195915
[lethal double infection with coxsackie virus a2 and influenza virus b in a 15-year-old girl]. 19695365460
live influenza b vaccine in volunteers. a report to the medical research council by their committee on influenza and other respiratory virus vaccines. 19695278156
influenza a2 and b in the ussr in 1966-67, and some aspects of global epidemiology of influenza.an epidemic wave of influenza caused by the a2 virus was recorded in the ussr in the winter of 1966-67; this was the fifth wave since this pandemic strain first appeared. in contrast to the last wave of 1965, it developed simultaneously with, or followed, an epidemic of influenza b. the epidemic spread of influenza was observed for a period of 2 years in the ussr; influenza b prevailed in 1966, influenza a2 in 1967, and the two viruses spread at different speeds. a slow spread and a gradual incr ...19695306546
summary report on hong kong influenza in japan.in the 2 months following the onset of the influenza epidemic in hong kong in july 1968, there must have been many importations of the virus into japan both from hong kong and from other countries subsequently involved in the epidemic. over a dozen such incidents were reported in japan and confirmed serologically or by direct virus isolation. although they must have seeded the virus at least in and near the ports of importation, a true epidemic of hong kong influenza did not start until october. ...19695309439
national influenza experience in the usa, 1968-69.an extensive outbreak of hong kong influenza occurred in the usa during the autumn and early winter of 1968-69. introduction and seeding of the virus occurred in september and early october as individuals returned from the far east. civilian outbreaks did not develop until late october and november. by 28 december, all states had experienced influenza outbreaks. limited information concerning age- and sex-specific attack rates indicates that all age segments of the population were equally involv ...19695309440
antibody responses to and efficacy of an inactivated spray vaccine.an attempt was made to assess the protective influence of killed intranasal influenza b vaccine against a homologous virus challenge. two types of trial were performed. in the first of these, the vaccine was compared with an inert placebo and, in the second, with conventional homologous and heterologous parenteral vaccines. little protective effect by the intranasal vaccine was demonstrated.19695309470
some studies on the selection and efficiency of live influenza vaccine viruses.live influenza virus vaccination has potential advantages and disadvantages compared with killed virus vaccine given by intramuscular injection.attempts have been made to achieve complete attenuation of influenza a2 and b strains by up to 30 serial passages in the allantoic cavity of eggs at 33 degrees c. no attenuation occurred. the method of passing viruses in the presence of an increasing concentration of horse serum, thus selecting inhibitor-resistant variants, has also been tested. it was s ...19695309479
the antiviral activity of the isoquinolines famotine and memotine in respiratory infections in man.a period of direct contact with a concentration of 20 mug/ml or less of either famotine (1-(p-chlorophenoxymethyl)-3,4-dihydroisoquinoline hydrochloride) or memotine (1-(p-methoxyphenoxymethyl)-3,4-dihydroisoquinoline hydrochloride) inactivates myxoviruses and paramyxoviruses. this activity has been confirmed in organ culture prepared from dog trachea and infected with an influenza a2 virus.consistent protection of mice infected intranasally with influenza a/pr/8 has not been obtained. other vir ...19695309492
susceptibility of the domestic pig to influenza b virus. 19694304929
substiuted sialic acid prosthetic groups as determinants of viral hemagglutination.inhibitors of hemagglutination by type a2 influenza virus and a recently isolated strain of type b influenza virus were separated by sucrose density gradient centrifugation and agarose gel filtration from horse serum. using selected reagents, it was demonstrated that the active substituent on the horse serum inhibitor of a2 influenza virus was 4-o-acetyl-n-acetylneuraminic acid; however, the active substituent on the inhibitor of the influenza b virus was shown to be n-acetylneuraminic acid (nan ...19694306720
prophylaxis of influenza b with uk 2054. 19694185593
[research on influenza virus inhibitors]. 196916089155
influenza in east africa, 1969-70.very little information is available concerning the frequency of influenza in east africa. following recent outbreaks of influenza in uganda, that were due to the a2/hong kong/68 virus, it was considered useful to obtain information relating to the prevalence of infection due to this virus and to the current strain of influenza b virus, not only in uganda but also in the neighbouring territories of kenya and tanzania. the results of serological testing of sera showed that widespread outbreaks of ...19705312523
evaluation of three cell culture systems as substrates for influenza virus assay.the propagation of various influenza virus strains in primary rhesus monkey kidney (rmk), primary hamster kidney (hk), and the mdck-usd canine kidney (ck) cell cultures was compared. virus-infected cultures were examined for cytopathic effect (cpe) and by performing the hemadsorption (had) technique. the highest had titers were found most often in hk, followed by rmk and ck. however, the ck cell line provided the best substrate for detecting cpe. although influenza b strains tended to grow to hi ...19704986726
an influenza b epidemic within a remote alaska community. serologic, epidemiologic, and clinical observations. 19705469025
chemoprophylactic effect of phenylethylbiguanide (dbi) on influenza a2 and influenza b virus infections in diabetic patients. 19705490569
the production of neutralizing activity in serum and nasal secretion following immunization with influenza b virus.trials were made in volunteers in 1967 and 1968 of various virus vaccines against influenza virus b. sera and serially collected nasal washings before and after immunization were tested respectively for haemagglutination-inhibiting and tissue culture virus-neutralizing antibodies to the same strain of influenza b/eng/65 virus as that used in the vaccines. infection, as determined by recovery of virus and serological changes following intranasal instillation of attenuated live virus, was accompan ...19705270204
neuraminidase- and hemagglutinin-inhibiting antibodies in serum and nasal secretions of volunteers immunized with attenuated and inactivated influenza b-eng-13-65 virus vaccines. 19705311581
plaque formation by influenza b viruses in primary calf kidney cell monolayes. 19715168242
a comparative study of attenuated influenza viruses.influenza a and influenza b viruses were adapted to growth at 25 degrees c. when given to volunteer subjects, the viruses were attenuated but remained infective and antigenic. the minimum immunizing dose of an egg-adapted virus appeared to be 10(5.0) eid(50). cloning by plaque selection at 25 degrees c gave seed cultures of relatively low infectivity titres. these titres were increased when necessary by passage at 33 degrees c. no reversion to virulence was observed.viruses attenuated in the uni ...19715316742
antigenic relationship between influenza b viruses.the object of this study was to determine whether antigenic groupings exist among influenza b viruses. altogether, 22 influenza type b strains isolated during the years 1940-68 were examined by reciprocal haemagglutination-inhibition, strain-specific complement-fixation, and serum neutralization tests with sera produced in ferrets and guinea-pigs. it was found that the strain-specific complement-fixation test was superior for separating influenza b viruses into groups whereas the haemagglutinati ...19715317011
the association of viruses with clinical pertussis.this study describes the results of attempts to grow viruses from per-nasal swabs taken from 136 children with clinical pertussis.altogether 37 strains of a variety of different viruses were isolated. adenovirus was the most frequent, making up 30% of the total. besides these, herpes simplex, measles, influenza a2, influenza b, mumps, poliovirus and respiratory syncytial virus were detected.bordetella pertussis was isolated from 22% of the cases.it appears that a pertussis-like syndrome can be c ...19714328794
analysis of antigenic and biological properties of influenza b virus strains, isolated in leningrad in 1955-1967. 19714400426
antibody responses and resistance to challenge in volunteers vaccinated with live attenuated, detergent split and oil adjuvant a2-hong kong-68 (h 3 n 2 ) influenza vaccines. a report to the medical research council committee on influenza and other respiratory virus vaccines.forty-nine subjects were vaccinated with either live attenuated, detergent split, or oil adjuvant a2/hong kong influenza vaccines, or a saline influenza b vaccine as control. respiratory symptoms occurred more frequently in subjects who received the live vaccine but in total there was little difference between the symptoms in the four groups. antibody titres in nasal washings and serum were measured by haemagglutination inhibition, neuraminidase inhibition and virus neutralization tests. the oil ...19724506997
the role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza a2 and b viruses.the intranasal inoculation of volunteers with living partially attenuated strains of influenza a and b viruses offers a new opportunity to determine the protective effect of serum haemagglutin-inhibiting antibody against a strictly homologous virus, under conditions where the time and dosage of the infective challenge can be controlled, the scoring of proven infections can be more precise and higher rates of infection can be achieved than in most natural epidemics.in 1032 adult volunteers, whose ...19724509641
antigenic relationships between the neuraminidases of influenza b virus.antigenic relationships between neuraminidases of influenza b viruses isolated from 1940 to 1968 were studied by neuraminidase-inhibition tests using hyperimmune rabbit antisera. the cross-reactions between the enzymes of influenza b viruses showed that some antigenic drift had occurred but that they are all related. from these results it is concluded that the differences between the neuraminidases of influenza b viruses are not sufficiently clear-cut to allow the viruses to be separated into su ...19724538191
the isolation of influenza viruses.of 129 strains of the hong kong variant of influenza a2 virus isolated from 176 respiratory infections, 105 (81.4%) were isolated in tissue culture, the remainder being detected only by the inoculation of fertile hen's eggs. organ cultures of chick embryo trachea were at least as sensitive as monkey kidney tissue culture for the isolation of this virus but organ cultures of human embryonic ciliated epithelium were much less efficient. the reverse was true for strains of influenza b virus studied ...19724625434
immunogenicity of egg-grown influenza vaccine: inhibition by immunization of recipients with host antigen.rabbit antibody directed against normal allantoic fluid reduced the protective power of influenza vaccine prepared from egg-grown pr8 virus. a similar vaccine prepared from mouse lung virus was not inhibited. preimmunization of mice with normal allantoic fluid or with egg-grown influenza b/lee vaccine (crude or purified) inhibited the protective power of pr8 egg vaccine but did not affect a similar lung vaccine.19724635503
[exanthematous course of influenza b disease in children]. 19725058421
an outbreak of reye's syndrome associated with influenza b. 19725060456
effect of isoprinosine against influenza and some other viruses causing respiratory diseases.the antiviral activity of isoprinosine was tested in tissue cultures and mice. in tissue cultures, concentrations of 25 to 100 mug/ml inhibited the infectivity of influenza and herpes hominis viruses but not parainfluenza virus, rhinovirus, or adenovirus. among different strains of influenza a, there was considerable variability in the inhibitory concentration of isoprinosine. for influenza b, a zone effect was observed in the inhibitory drug concentration. oral prophylactic administration of is ...19724790561
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