Publications

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biologically active dna of bacteriophage lambda. 19665223584
function of the n cistron of bacteriophage lambda. 19665225510
regional and temporal control of genetic transcription in phage lambda. 19665225516
assembly of phage lambda in vitro. 19665227665
theory of thermal transitions in cohered dna from phage lambda. 19665230176
[the conditions for spheroplast infection by isolated lambda phage dna]. 19664865882
[a mutant of bacteriophage lambda, resistant to acridine orange]. 19664178198
[on the inhibition of lambda phage production in nutrient broth]. 19664229809
induction and multiplication of lambda-phage. i. the effect of chloromycetin. 19664860460
host specificity of dna produced by escherichia coli. 8. its acquisition by phage lambda and its persistence through consecutive growth cycles. 19664863697
vegetative bacteriophage lambda-dna. i. infectivity in a spheroplast assay. 19674865142
vegetative bacteriophage lambda-dna. ii. physical characterization and replication. 19674865143
on the mechanism of derepression of host galactose operon following induction of bacteriophage lambda in escherichia coli strain k12. 19674860630
the biosynthesis of phage lambda dna: the structure of the first intermediate. 19674861305
[the replication of "precocious" defective mutants of lambda phage]. 19674167022
the restriction of bacteriophage lambda in escherichia coli strain w. 19674866792
mutants of bacteriophage lambda unable to integrate into the host chromosome. 19674867663
behavior of lambda bacteriophage in a recombination deficienct strain of escherichia coli.the behavior of lambda phage in the rec(-) strain jc-1569 is compared with that in the rec(+) strain jc-1557. no difference deemed significant was noted in the adsorption rate, latent period, burst size, frequency of lysogenization, and frequency of vegetative phage recombination. the location of the prophage and its mode of insertion in the rec(-) lysogen of wild-type lambda (lambda(+)) were inferred to be normal from the results of conjugational crosses. spontaneous and ultraviolet (uv) irradi ...19674918235
adsorption of phage lambda cb2 in tetracycline-resistant escherichia coli k12. 19674873410
asymmetric distribution of the transcribing regions on the complementary strands of coliphage lambda dna. 19675231395
regulation of bacteriophage lambda dna replication. 19675242210
initiation of infection by deoxyribonucleic acid from . . . bacteriophage lambda.kinetic studies conducted on the early stages of infection of escherichia coli k-12 by deoxyribonucleic acid (dna) isolated from bacteriophage lambda indicate a rapid adsorption of the phage dna to receptor sites at the bacterial surface prior to deoxyribonuclease-insensitive incorporation. a direct relationship found between the number of dna molecules adsorbed per bacterium and the multiplicity of helper phage infection indicates a requirement for helper function during the attachment process. ...19674960182
effects of lambda-phage infection on bacterial synthesis. 19675339797
absortive lysogenization of bacteriophage lambda b2 and residual immunity of non-lysogenic segregants. 19675340186
effect of ultraviolet irradiation on bacteriophage lambda immunity. 19675340187
inhibition of growth of rii mutants of bacteriophage t4 by immunity substance of bacteriophage lambda. 19675340188
transcription of complementary strands of phage lambda-dna in vivo and in vitro. 19675340634
mapping of integration and excision crossovers in superinfection double lysogens for phage lambda in escherichia coli. 19675341475
heat-inducible lambda phage. v. induction of prophages with mutations in genes o, p, and r. 19675583727
deletions and functions of the center of the phi80 -lambda phage genome. evidence for a phage function promoting genetic recombination. 19675584569
isolation and characterization of new sus (amber) mutants of bacteriophage lambda. 19675591286
[on a method of comparing the radiosensitivity of the dna of the "operating" and "programming" structures of the genome of lambda phage following the indirect effect of radiation]. 19675616248
protein components of bacteriophages lambda and lambda virulent.parallel studies have been made of the protein coats of the temperate bacteriophage lambda and of a deletion mutant, lambda virulent. a new method for preparing ghosts of both phages by the action of cu(++) is described. protein ghosts of both phages can be dissolved in citrate at ph values below 3, more rapidly in the presence of 8 m urea. both phages yielded three apparently identical protein components which can be separated by thin-layer gel filtration and thin-layer gel electrophoresis. the ...19675621486
integration-negative (int) mutants of phage lambda. 19676017405
an exonuclease induced by bacteriophage lambda. i. preparation of the crystalline enzyme. 19676017736
an exonuclease induced by bacteriophage lambda. ii. nature of the enzymatic reaction. 19676017737
early functional mutants of . . . coliphage lambda.the early functional mutants of lambda, belonging to cistrons n, o, and p, are known to be blocked prior to vegetative multiplication of the lambda genome. superinfection of heteroimmune defective lysogens by these mutants failed to elicit the function required for replication of the superinfecting phage. the mutants among themselves also showed poor cooperation on a nonpermissive host. studies on the effects of different multiplicities of infection for bacterial lysis showed identical responses ...19676020563
bacteriophage lambda dna with different structures found in infected cells. 19676031718
specific binding of the lambda phage repressor to lambda dna. 19676034235
infectivity of single-stranded rings of bacteriophage lambda dna. 19676051748
formation of intermediates in the replication of phage lambda dna. 19676051752
phage lambda mutants deficient in r-ii exclusion.the lambda gene responsible for r(ii) exclusion is distinct from other lambda genes and lies between the n and c(i) genes on the genetic map.19676060364
formation of bacteriophage lambda infective particles from lambda dna in the presence of the crude extract of escherichia coli k12 s. 19675336882
studies of heat-inducible lambda phage. iv. conversion of host phenotype by a defective prophage. 19675337608
mapping the 5'-terminal nucleotides of the dna of bacteriophage lambda and related phages. 19674292665
mutations in bacteriophage lambda affecting host cell lysis.nine temperature-sensitive and defective mutants of phage lambda deficient in lysis of the host cell have been analyzed in respect to location of the site of mutation and phenotypic properties. seven of the isolates are mutant in cistron r and produce either a thermolabile endolysin or no detectable enzyme. the remaining two mutants, one temperature-sensitive and one defective, produce high levels of apparently normal enzyme. these mutants denote the involvement of at least one phage cistron oth ...196718614056
fractionation of the complementary strands of coliphage lambda dna based on the asymmetric distribution of the poly i,g-binding sites.poly i,g interacts preferentially with one of the two complementary dna strands of lambda and lambda-related phages 21, 434, and phi80, thus permitting preparative separation of the "dense" fraction, consisting of a complex between the intact strands c and poly i,g, from the less dense ("light") fraction containing the intact strands w, which bind 3-4 times less poly i,g. the isolated and self-annealed fractions are over 99% pure as far as their hybridization properties with complementary rna ar ...196718614063
effects of uncouplers of oxidative phosphorylation on the infection of escherichia coli k12 by phage-lambda dna.some effects of two uncouplers of oxidative phosphorylation on infection of escherichia coli k12 by bacteriophage lambda deoxyribonucleic acid (dna) are described. dinitrophenol did not interfere with the initial interaction of the cells with free dna, and neither dinitrophenol nor carbonyl cyanide m-chlorophenylhydrazone affected the linear portion of the infection reaction. however, the process by which lambda-dna bound to the bacterial cell became insensitive to deoxyribonuclease was strongly ...196718614068
an investigation of bacteriophage lambda, its protein ghosts and subunits.the sedimentation coefficients and molecular weights of bacteriophage lambda and its ghost were determined as so(20,w) = 416 x 10(-13) second and m = 57 x 10(6) for the virus, and so(20,w) = 141 x 10(-13) second and m = 21 x 10(6) for the ghost. the protein portion of the virus consists of at least two distinct types of subunits, with molecular weights of 55,000 and 110,000, which differ markedly in their amino acid content.196718614077
suppression of the heat-sensitive mutants of the coliphage lambda. 196718614096
isolation of the lambda phage repressor. 196716591470
host survival following infection with or induction of bacteriophage lambda mutants.the lethal effects of lambda infection and lambda induction were studied using conditional lethal mutants of phage lambda in the su- host w3350. phage with mutations in q and r, which are blocked after dna replication, kill promptly and efficiently on induction or infection. infection with mutants defective in o and p, which do not replicate, kills less efficiently, although these mutants do kill effectively at high multiplicity of infection. heat induction of lysogens carrying dna defective mut ...196818614112
suppressor-sensitive mutants of coliphage phi80.about fifty suppressor sensitive (sus) mutants of phage phi80 were isolated after hydroxylamine treatment, and these were classified into fourteen cistrons. in vitro and in vivo complementation experiments revealed that at least five cistrons were concerned with head formation and that at least six cistrons were concerned with tail formation in phi80. some presumed "early" mutants were also found. defective lysogens were isolated from a phi80-lysogenic nonpermissive strain using the colicin plat ...196818614128
production of single-strand breaks in covalent circular lambda phage dna in superinfected lysogens by monoalkylating agents and the joining of broken dna strands.fast sedimenting, double-stranded, covalent circular lambda phage dna in superinfected lysogens of escherichia coli is converted to notched circular dna, sedimenting slowly in alkaline sucrose gradients, by methylmethane sulfonate (mms) treatment during incubation at 37 degrees . during further incubation after removal of the mms, the slow sedimenting dna reverts to the fast sedimenting structure. covalent circular dna, phenol extracted from superinfected lysogens and exposed to mms, ethylmethan ...196818614129
structure and base sequence in the cohesive ends of bacteriophage lambda dna. 19684299833
in vitro repression of phage lambda dna transcription by a partially purified repressor from lysogenic cells. 19685238651
integration-negative mutants of bacteriophage lambda. 19685637199
mutations in bacteriophage lambda affecting particle morphogenesis. 19685652675
studies on the genetics of biotin-transducing, defective variants of bacteriophage lambda. 19685669988
induction and multiplication of lambda-phage. ii. the effect of valine and leucine. 19685679785
disruption of t-even bacteriophages by dimethyl sulfoxide.dimethyl sulfoxide (dmso) disrupted t-even bacteriophages as well as lambda bacteriophage. the component substructures of t2l, t4b01, or t6, in particular heads, were readily isolated after treatment with 67% dmso (v/v). in contrast, concentrations of dmso above 50% not only separated heads from tails of bacteriophage lambda but led to degradation of the lambda heads. examination of the isolated free heads of t-even bacteriophage indicated that a distinct neck substructure was attached to one ap ...19685697471
gene orientation in bacteriophage lambda as determined from the genetic activities of heteroduplex dna formed in vitro. 19685700418
genetics of the left arm of the chromosome of bacteriophage lambda. 19685705826
genetic transcription in bacteriophage lambda: studies of lambda m rna synthesis in vivo. 19685719216
evidence for a new endonuclease synthesized by lambda bacteriophage.infection of nonlysogenic escherichia coli cr34(s) (thy(-)) with bacteriophage lambda c(i)857 resulted in the formation of twisted circular double-stranded phage deoxyribonucleic acid (dna; species i). when such infected bacteria were incubated in the absence of thymine, there was a significant decrease in the amount of species i dna after 60 min of incubation. a similar loss of species i lambda dna during incubation in a thymine-deficient medium was also observed after infection of the endonucl ...19685723713
[elimination of t4rii by c-mutants of the lambda phage]. 19685745532
integrative recombination function of bacteriophage lambda: evidence for a site-specific recombination enzyme. 19685760457
recombination in bacteriophage lambda. i. mutants deficient in general recombination. 19685760458
recombination in bacteriophage lambda. ii. site-specific recombination promoted by the integration system. 19685760459
the role of the n gene of phage lambda in the synthesis of two phage-specific proteins. 19684973489
physiology of bacteriophage lambda in the restrictive host. 19684938540
mutants of bacteriophage lambda defective in vegetative genetic recombination. 19684938547
segmental distribution of nucleotides in the dna of bacteriophage lambda. 19684999721
replication of bacteriophage dna. i. replication of dna of lambda phage defective in early functions. 19684941475
replication of bacteriophage dna, ii. structure of replicating dna of phage lambda. 19685243927
the operators controlled by the lambda phage repressor. 19685244737
studies of the messenger rna of bacteriophage lambda, i. various species synthesized early after induction of the prophage. 19685246538
the general recombination system of bacteriophage lambda. 19685254579
site-specific recombination in bacteriophage lambda. 19685254580
integration, excision, and transducing particle genesis by bacteriophage lambda. 19685254581
the integration and excision of the bacteriophage lambda genome. 19685254582
the regulation and mechanism of dna synthesis in bacteriophage lambda. 19685254585
[comparative characteristics of oxygen consumption and electrokinetic potential of escherichia coli under the effect of moderate and virulent coliphage. 1. effect of the induction of lambda-phage production on oxygen consumption and electrophoretic motility of e. coli k12 lambda]. 19684873878
effect of mutation to streptomycin resistance on amber suppressor genes.three classes of nonidentical streptomycin-resistant mutations were distinguished in escherichia coli by their effect on the efficiency of suppression by an amber suppressor gene, sup e. the first class of mutation caused a strong restriction in efficiency of suppression of an amber codon in various cistrons of phage lambda and in an alkaline phosphatase structural gene of e. coli. the second class caused weak restriction, and the third class caused no restriction. the restrictive effect of the ...19684874314
the effect of amino acids on host-controlled restriction of lambda phage. 19684876151
production of single-strand breaks in covalent circular lambda phage dna in superinfected lysogens by monoalkylating agents and the joining of broken dna strands. 19684878021
mutants of phage lambda unable to exclude phage t4rii. 19684878024
studies on radiation-sensitive mutants of e. coli. ii. breakage and repair of ultraviolet irradiated intracellular dna of phage lambda. 19684879098
relationship between k-reactivation and uv-reactivation of bacteriophage lambda. 19684879191
cis-trans position effect of certain genes controlling tail protein in bacteriophage lambda. 19684881035
effect of ribonucleic acids on the infectivity of phage lambda dna. 19684881146
sedimentation of dna from bacteriophage lambda-infected escherichia coli. 19684881148
effect of lysogeny on serum sensitivity.when escherichia coli k-12 was infected with lambda phage and mutants of lambda characterized by the production of temperature-sensitive repressors, the lysogenic bacteria were significantly more resistant to normal serum than the uninfected organisms. infection of e. coli k-12 with a lambdoid phage, phi80, whose prophage attachment site is different from that of lambda, did not result in a detectable change in serum resistance. similarly, infection with certain pseudomonas and shigella phages c ...19684881698
studies on head-tail union in bacteriophage lambda. 19684882733
replication of phage lambda dna. 19684891991
properties of mitomycin c-sensitive mutants of escherichia coli k-12.strains hypersensitive to mitomycin c (mc) were isolated from escherichia coli k-12 after treatment with nitrosoguanidine. of 43 mc-sensitive strains tested for their ultraviolet light (uv) sensitivity and for their ability to reactivate uv-inactivated lambda phage, 38 were found to be insensitive to uv irradiation and to be able to reactivate uv-irradiated bacteriophage lambda. some properties of the mc-sensitive, uvr(+) mutants were analyzed. synthesis of deoxyribonucleic acid (dna) in mc-sens ...19684867746
mechanism ofhost-controlled restriction of bacteriophage lambda by r factors in escherichia coli k12. 19684867907
evidence for independent segregation of the escherichia coli chromosome and non-replicating bacteriophage lambda b2. 19684868426
attachment and detachment of bacteriophage lambda dna in lysogenization and induction. 19684868761
[the effect of cystamine and magnesium ions on the induction of moderate lambda phage by x-rays]. 19684869266
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