Publications

in vitro assessment of effects of persistent organic pollutants on the transactivation of estrogen receptor α and β (erα and erβ) from the baikal seal (pusa sibirica).	to assess the effect of exposure to persistent organic pollutants (pops) on the estrogen receptor (er) signaling pathway in baikal seals (pusa sibirica), we investigated the molecular characterizations and functions of two baikal seal er (bser) isoforms, bserα and bserβ. the bserα and bserβ cdna clones isolated have an open reading frame of 595 and 530 amino acid residues, respectively. the tissue distribution analyses of bser mrnas showed that bserα transcripts were primarily found in the ovary ...	2019	31228822
in vitro and in silico evaluations of binding affinities of perfluoroalkyl substances to baikal seal and human peroxisome proliferator-activated receptor α.	in this study, we assessed the binding affinities of perfluoroalkyl substances (pfass), including perfluoroalkyl carboxylates (pfcas) and perfluoroalkyl sulfonates (pfsas), to the ligand-binding domains (lbds) of baikal seal ( pusa sibirica; bs) and human (h) peroxisome proliferator-activated receptor alpha (pparα). an in vitro competitive binding assay showed that six pfcas and two pfsas could bind to recombinant bs and hpparα lbd proteins in a dose-dependent manner. the relative binding affini ...	2019	30649875
mercury loading within the selenga river basin and lake baikal, siberia.	mercury (hg) loading in lake baikal, a unesco world heritage site, is growing and poses a serious health concern to the lake's ecosystem due to the ability of hg to transform into a toxic form, known as methylmercury (mehg). monitoring of hg into lake baikal is spatially and temporally sparse, highlighting the need for insights into historic hg loading. this study reports measurements of hg concentrations from water collected in august 2013 and 2014 from across lake baikal and its main inflow, t ...	2020	32023784
freshwater seal as a source of direct and indirect increased human exposure to persistent organic pollutants in a background area.	the aim of the study is to investigate pop levels in environmental media (air, snow, soil and sediment), certain food items in the olkhon district (irkutsk region, russia) and lake baikal seal (nerpa) fat and meat in order to define the main pathways of elevated human exposure to pops in the area. pop levels in soil and air samples and in almost all of the food items from the olkhon district were comparable to levels in background areas of the lake baikal region. only certain chicken eggs, large ...	2020	32041048