Publications

cardioprotection by the calcium antagonist pn 200-110 in the absence and presence of cardiodepression.	the globally-ischaemic langendorff rabbit heart model has been used to study the cardioprotective effects of the dihydropyridine pn 200-110 (pn) at two doses, one having no negative inotropic effect and a higher dose causing a 62 +/- 5% reduction in contractility. following 45 min no-flow global ischaemia, recovery was monitored for a period of 90 min reperfusion. hearts were paced at a constant rate throughout experiments. contractile force and coronary flow were recorded continuously. tracer m ...	1985	2932193
experimental studies on the influence of fibrin adhesive, factor xiii, and calcitonin on the incorporation and remodeling of autologous bone grafts.	in an experimental study on sheep the effects of fibrin adhesive system (fas), plasma factor xiii (fxiii), and calcitonin on autologous cancellous bone grafts were studied. drill holes in the tibia were filled with transplant bone, either untreated or locally treated with fibrin adhesive, with or without plasma factor xiii. we used 24 sheep, divided into three groups. plasma factor xiii and calcitonin were administered parenterally; the third group received no treatment. for evaluation we carrie ...	1986	2436594
oscillation of cyclic amp with the heart cycle of the canine myocardium in situ.	oscillations of cyclic amp with the cardiac cycle were demonstrated in the canine heart in situ. for tissue sampling an ecg(r-wave)-triggered, automatically working push-freeze-drill apparatus was employed which allowed intraventricular cryobiopsies from the left ventricular muscle of anaesthetized open-chest dogs. the nucleotide cyclic amp oscillated with the cardiac cycle during normal working conditions, the higher cyclic amp values occurring during systole. cyclic gmp was assayed to be witho ...	1986	3008710
effects of acute tachycardia on left ventricular adenine nucleotide levels and subsequent tolerance to ischemia.	electrophysiologically guided surgical procedures for the ablation of supraventricular and ventricular dysrhythmias often require prolonged periods of tachycardia to complete intraoperative mapping studies. it is unknown whether tachycardia depletes the myocardium of high-energy compounds or alters subsequent tolerance to ischemia. in the present study, 12 anesthetized dogs were paced from the right ventricle at a cycle length of 250 msec for 60 minutes. in seven animals, drill biopsy specimens ...	1986	3773548
early and late dilatation for acquired subglottic stenosis.	there has been widespread use of periodic dilatations in the management of subglottic stenosis. however, some authorities have questioned the value in the overall rehabilitation of patients affected by this disorder. the first phase of this study included fourteen large dogs in which acute subglottic lesions were created by use of a high-speed electric drill and electrocautery. twelve animals served as the experimental group and two animals were controls. obstructing lesions developed in all the ...	1986	3108795
the effect of carbon dioxide laser irradiation on cranial bone healing. an experimental study.	an experimental study on the effects of carbon dioxide laser irradiation osteotomy of the calvarium of 4-week old rabbits was compared with tht of an osteotomy performed with a high speed drill. histological studies of calvarium cross sections were performed at 2, 4 and 6 weeks following the osteotomies. as early as 2 weeks following high speed drill osteotomy connective tissue bridged the bone edges. by 4 weeks this bridge was thickened and endowed with numerous vessels. at 6 weeks numerous ost ...	1986	3098420
co2 laser management of laryngeal stenosis.	the introduction of the carbon dioxide laser as an endoscopic surgical instrument has stimulated interest in its application for removal of stenotic lesions of the larynx. clinical reports have indicated mixed results in the efficacy of this treatment modality. nineteen large dogs received acute subglottic injuries from a high-speed electric drill and electrocautery. all animals developed obstructing lesions from 7 to 21 days after injury. with at least weekly removal of granulation tissue and d ...	1986	3106914
effects of prostaglandins on regional remodeling changes during tibial healing in beagles: a histomorphometric study.	a histomorphometric study was carried out on bone samples in the region of healing defects in the tibias of beagles of various ages. a 5 mm diameter drill hole defect was made in the mid-shaft of the tibia. eleven of the beagles received either vehicle (n = 6) or prostaglandin e2 orally (n = 5) for the 30-day period from surgery to time of necropsy. ten dogs received local injections of vehicle (n = 4) or prostaglandin e1 directly into the defects for the first 10 days after surgery. double labe ...	1986	3093031
localization of technetium-99m methylene diphosphonate in bone using microautoradiography.	technetium-99m methylene diphosphonate ([99mtc]mdp) is the most widely used bone-scanning agent today. in order to determine the precise bone locus of 99mtc corresponding to the delayed bone scan image, and to test the potential clinical use of this agent in enhancing the information obtained by bone scan, we employed [99mtc]mdp in this microautoradiographic study of normal bone and bone reparative tissue. four white rabbits underwent operations in which two 1.5-mm drill holes were created in th ...	1986	3712127
results of treatment of primary breast carcinoma by radical radiotherapy with artificial pneumothorax.	one hundred and forty-three women with primary breast carcinoma were treated by radical radiotherapy associated with artificial pneumothorax to include the breast and lymphatics en bloc with large opposed fields. surgery was restricted to local excision or drill biopsy. most patients received a tumour dose of 5200-5600 cgy in 19-22 fractions over 4 weeks and were followed up for at least 5 years. local control was achieved in 87% of t1, 52% of t2, 27% of t3 and 23% of t4 tumours. for t2 tumours ...	1986	3731697
epiphysiodesis: evaluation of a new technique.	proximal tibial epiphyseal fusion was performed in immature black labrador retriever dogs using an 8-mm drill followed by a high-speed burr. epiphysiodesis was complete at 2 weeks in all experimental animals (average growth of 1.5 mm, whereas the unoperated side averaged 5.9 mm of growth). minimal surgical exposure resulted in less pain in the experimental animals than in those undergoing epiphysiodesis by traditional means. this new technique may be of use in pediatric orthopedic patients.	1986	3958166
shear strength of loaded porous-glassy-carbon/bone interface--an experimental study on rabbits.	the aim of the study was to measure the shear strength of bone/porous-glassy-carbon interface in rabbit. glassy carbon pellets were implanted into drill holes made through the medial articular surface of the proximal tibia of 15 rabbits. shear strengths grew statistically significantly from 1 to 6 weeks and reached a maximum of 4.6 mn/m2. microscopical examination of the sheared surfaces revealed that at 1 and 2 weeks the shearing occurred through the tissue surrounding the implant, and at 3, 6 ...	1986	3789487
fracture properties of bovine tibial bone.	linear elastic fracture mechanics predicts that the fracture stress of precracked materials is dependent on the length of the initial crack tip radius of curvature, as supported by the griffith and inglis equations. in order to determine the applicability of these equations and the effects of other variables, tensile specimens of bovine tibia were produced with edge cracks of known dimensions and tested to fracture. longitudinal sheet tensile specimens were taken from the midposterior diaphysis ...	1986	3793740
[osteoma of the sphenoid sinus--report of two cases].	although osteoma of the paranasal sinus is comparatively common, involvement of the sphenoidal sinus region is extremely rare. lame reported that a total of twelve cases had been described in the european literature since 1800. mikaelin, kulczynski and dolan, since then, described three cases. this paper deals with two surgical cases of sphenoidal sinus osteoma, reviewing literature on paranasal sinus osteoma and differential diagnosis in the sphenoidal sinus lesion. case 1. a 20-year-old man wa ...	1986	3808213
acute hematogenous staphylococcal osteomyelitis: the effects of surgical drilling and curettage in an animal model.	surgical drilling and curettage of metaphyseal medullary bone were performed in chickens 4, 8 and 15 d after bacterial inoculation with staphylococcus aureus producing osteomyelitis. intramedullary drilling and curettage resulted in extensive vascular damage and necrosis of medullary bone but failed to remove all viable bacteria. an effective continuing drainage channel for the pus was not established due to the formation of blood clot within the drill hole. surgery performed before the formatio ...	1986	3763244
applications of hand-arm models in the investigation of the interaction between man and machine.	the mode of vibration of hand-held tools cannot be considered without knowledge of the influence of the operator's hand-arm system. therefore some technical applications of hand-arm models were realized for drill hammers by the university of dortmund. these applications are a software program to simulate the motion of machine components, a horizontal drilling jig, and a chucking device in a drilling rig.	1986	3775320
artifacts in mr imaging after surgical intervention.	artifacts are encountered repeatedly in magnetic resonance (mr) imaging after neurological orthopedic surgery, although there is no evidence of metallic foreign bodies on radiography and ct. experiments demonstrated that surgical filling materials, such as bone cement and bone transplants are not the cause of the artifacts. on the other hand, we have been able to show that short-term contact between a diamond drill and untempered operating instruments can cause abrasions and set free minute meta ...	1986	3525623
temperatures during drilling for the placement of implants using the osseointegration technique.	the temperatures elicited during drilling according to the osseointegration technique were measured in vivo in five edentulous human mandibles. the temperature changes were measured by a thermocouple, the tip of which was situated 0.5 mm from the drill surface and separated from it by a cortical wall. eighteen measurements showed a mean initial temperature of 29.2 degrees c before drilling and a mean maximum temperature of 30.3 degrees c during drilling. the maximum temperature recorded was 33.8 ...	1986	3455722
interactive instruction in the radiographic anatomy of the chest.	an instructional program has been developed which is designed to instruct medical students in a systematic approach to the reading of the chest radiograph. a videodisc player is used to display a radiograph on a video monitor and computer graphics are superimposed over this image. another feature is the use of a mouse pointer as an input device to identify structures on the radiograph. the instructional approach is based upon the drill and practice method. all questions and responses are created ...	1986	3516561
[value of drill-biopsy in breast cancer].	this study reports the results of 649 drill biopsies performed on breast tumors before any treatment. diagnostic of malignancy was achieved with a drill biopsy in 89% cases (579/649 procedures). pathological subtypes, i.e. common infiltrating types, special pathological types, were determined in 98% cases (566/579), while histo-prognostic grading, according to scarff, bloom and richardson, was performed in 98% of the common infiltrating type carcinomas (498/507). reliability of the technique was ...	1987	3567382
surgical anatomy of the round window with special reference to cochlear implantation.	when the multi-channel cochlear implant electrode is inserted into the scala tympani through the round window the operation is best performed via a posterior tympanotomy. the view of the round window membrane, however, is incomplete because of its orientation and the fact that it has a conical shape. nevertheless, a good view along the basal turn is obtained after the antero-inferior overhang of the round window niche and the crista fenestrae have been removed. it might be damaging to drill away ...	1987	3572226
skeletal localization of samarium-153 chelates: potential therapeutic bone agents.	a series of stable complexes of 153sm has been produced using multidentate acetate and phosphonate ligands. biodistribution studies in unanesthetized rats showed varying degrees of bone and soft-tissue uptake for these complexes. of the complexes studied, [153sm] ethylenediaminetetramethylenephosphonate (edtmp) showed the best combination of high bone uptake, low nonosseous uptake, and rapid blood clearance which warranted its further investigation in rabbits. rabbit studies confirmed the [153sm ...	1987	3572535
[the effect of drill holes on the cortex of long bones].		1987	3591189
[optimization of the spiral drill for use in medicine].	cutting tools are used in medicine a long time ago. varying mechanical and thermal damage to bone tissue results from using cutting tools. these are often commented in the literature, but there is hardly any systematic studies of optimization of cutting tools. this present study was initiated in an attempt to improve the drill bit geometry and machining conditions. the study includes the thermal damage of bone and the soft-tissue injury, especially beyond the bone, by drilling of bone. the resul ...	1987	3673178
[strangulation of the penis by a ring].	a 42-year-old man was hospitalized with urinary retention due to strangulation of the penis in december, 1981. he placed a stainless steel ring on the base of the penis to prolong erection one month earlier, but subsequent penile edema made it impossible to remove the ring. on admission the penis was extremely swollen (15 cm in length and 7 cm in diameter). gangrenous patches covered the surface of the penis almost completely and the ring had cut through all the tissues superficial to buck's fas ...	1987	3445854
[bone induction with bone morphogenic protein].	32 experiments in 22 rabbits were performed to investigate the bone regeneration after implantation of lone morphogenetic protein (bmp) in a 6 mm drill-hole of the distal femoral condyle. two different bmp products have been used. a bone regeneration is to be observed partially at the surface of bmp, but in comparison to the control defects quantitatively insignificant. there is a significant difference in comparison to the bone substitutes collapat and pyrost, which proved well (highly signific ...	1987	3433911
biomechanical effects of point configuration in kirschner-wire fixation.	the drilling and bone holding properties of kirschner wires of three different tip designs have been investigated. the tip designs studied were the commercially available trocar- and diamond-shaped tips and the homemade cut tip produced by cutting the pin obliquely with wire cutters. thirteen canine metacarpals were drilled with wires of each tip design at 400 and 800 rpm. a servohydraulic test machine (materials test systems, minneapolis, mn) simultaneously measured axial loads, torque, and dis ...	1987	3791743
a biomechanical comparison of different surgical techniques of graft fixation in anterior cruciate ligament reconstruction.	different surgical methods of graft fixation in acl reconstruction were examined to determine the effects on mechanical properties of the reconstructed acl. ten human cadavers were used in this study. six different types of grafts were studied. the tendon grafts were removed from each cadaver and fixed to femurs and tibias as acl substitutes with different surgical fixation methods, leaving femur-reconstructed graft-tibia preparations. the surgical techniques used were staple fixation, tying sut ...	1987	3303979
[microangiographic research on revascularization in the fracture model of the canine tibia].	micro-angiograms were performed between eight weeks and one year following osteotomies and pressure osteosyntheses in 34 dog tibiae. seventeen animals also underwent lumbar sympathectomy. in more than half of the cases, vascularisation of the medulla was reduced by damage to the nutrient artery. segmental connections could be demonstrated by means of transcortical anastomoses. following sympathectomy, revascularisation was more marked as a result of numerous trans-osseus anastomoses. this, howev ...	1987	3031762
fixation of experimental osteotomy of the distal femur with biodegradable thread in rabbits.	a distal femoral osteotomy on 24 rabbits was fixed with biodegradable polyglycolic acid (pga) thread pulled through drill holes made on both sides of the osteotomy. follow-up times were one, three, six, 12 and 24 weeks. the distal part of each femur was removed, fixed in alcohol, embedded in methylmethacrylate, sawed to 80 microns thick for oxytetracycline (otc)-labeling studies and microradiography, and sectioned at 5 microns for histologic studies. as judged by histologic microradiographic, an ...	1987	3038446
[innervation of the stapedius muscle. a study using horseradish peroxidase in the guinea pig].	the numbers and locations of motoneurons to the stapedius muscle were determined by retrograde axonal transport of horseradish peroxidase (hrp) in the guinea pig. with the aid of a drill the bulla was opened and the stapedius muscle exposed. hrp solution (0.2-0.3 microliter) was injected into the muscle. following a survival time of 1-2 days the animals were perfused with a fixative and the brains were removed. frozen sections were reacted fro the demonstration of hrp using tetramethylbenzidine ...	1987	3586793
the effect of a penetrating biodegradable implant on the epiphyseal plate: an experimental study on growing rabbits with special regard to polyglactin 910.	a polyglactin 910 rod 3.2 mm in diameter and 25 mm in length was driven in a drill hole in the intercondylar portion of the right femur across the central portion of the growth plate in 20 5-week-old rabbits. the follow-up times were 3, 6, 12, and 24 weeks. the distal femoral growth plates of both femurs were analyzed by radiographic, microradiographic, and oxytetracycline fluorescence, histological, and histomorphometric studies. histomorphometric studies showed clear changes at injury site and ...	1987	3611337
[transposition of the medial meniscus as an anterior cruciate ligament replacement in animal experiments].	in 24 rabbits the anterior cruciate ligament was resected and replaced with the medial meniscus. the posterior and middle part of the meniscus was dissected from the capsule. the anterior horn remained in biological fixation. the posterior horn was fixed with a wire under tension and placed in a drill hole through the lateral femoral condyle. after 6 weeks, 3 months and 6 months the ligamentous replacement was examined. colour and strength of the transplanted meniscus was related to tension of t ...	1987	3673177
[not available].	some ideas, whether right or wrong, seem never to die, whatever might be the general evolution of knowledge, of science, or simply of good common sense. this is exactly the case with physical education or sports. for centuries, and especially since the middle of the nineteenth century, its advocates have fought for recognition of its all-round virtues, taken as a concept. but to attain a high level of recognition, not only in society but in official government circles, certain conditions were ne ...	1987	11617215
plasmid incidence in bacteria from deep subsurface sediments.	bacteria were isolated from deep terrestrial subsurface sediments underlying the coastal plain of south carolina. a total of 163 isolates from deep sediments, surface soil, and return drill muds were examined for plasmid dna content and resistance to the antibiotics penicillin, ampicillin, carbenicillin, streptomycin, kanamycin, and tetracycline. mics of cu, cr, and hg for each isolate were also determined. the overall frequency of plasmid occurrence in the subsurface bacteria was 33%. resistanc ...	1988	16347789
the effect of trauma to the lower femoral epiphyseal plate. an experimental study in rabbits.	forty-four rabbits were operated on when five weeks old; in one group a 2 mm drill-hole was made in the intercondylar portion of the right femur across the central portion of the growth plate up to the diaphysis, while in the other group a similar drill-hole of 3.2 mm was made. at 3, 6, 12 and 24 weeks after operation, specimens from the growth plates of both femora were analysed using radiographic, microradiographic, histological and histomorphometric techniques. it was found that destruction o ...	1988	3346285
strength reductions from metastatic cortical defects in long bones.	the purpose of this investigation was to measure the reduction in bone strength resulting from drill holes in diaphyseal bone and to compare this with finite element and theoretical predictions for stresses in a tubular structure. fifty-two pairs of canine femora were tested to failure in four-point bending. one bone of each pair was used as the control; the other femora had holes of variable size drilled in the lateral cortex. at a ratio of drill hole diameter to bone diameter of 0.2, the bone ...	1988	3357085
systemic effects of prostaglandin e2 on vertebral trabecular remodeling in beagles used in a healing study.	prostaglandin e2 (pge2) at a dose of 10 mg/kg was administered orally to beagles used in a study of rib fracture and drill hole defect healing. double fluochrome labels were given prior to surgical manipulation and before necropsy at 30 days. bone remodeling was evaluated in trabecular bone of the fourth lumbar vertebra. there was a decrease in the number and extent of posttreatment labels (p less than 0.05) in the controls, with decreased mineral apposition rate (p less than 0.05) and decreased ...	1988	3135105
use of an aiming device for application of a type-ii (bilateral) external fixator to a fractured tibia of a dog.	an aiming device was used to guide insertion of fixation pins in a type-ii (bilateral) external fixator stabilizing an open canine tibial fracture. this device, designed by the swiss ao group, has multiple applications in orthopedic surgery, because it accurately locates the exit point of a pin or drill hole on the far side of a bone or fractured bone fragment. when used with the type-ii external fixator, it greatly facilitates pin placement by ensuring that, as a pin emerges from the bone, it i ...	1988	3410775
the effects of bulk versus particulate ultra-high-molecular-weight polyethylene on bone.	fourteen mature new zealand white female rabbits underwent implantation of a bulk pellet and of particulate (less than 1,000 micron) ultra-high-molecular-weight polyethylene (uhmwpe), through a drill hole in the proximal right tibia. the left tibia served as a drilled but nonimplanted control. the rabbits were killed after 16 weeks. histologic examination of the bone-implant interface in the bulk uhmwpe group disclosed a fibrous tissue membrane with infrequent giant cell and histiocytic clusters ...	1988	3058870
risk evaluation and patient assessment in sedation.	risk assessment gives a good clinical guide to the understanding of our patients' medical problems. the dentist can cope with problems related to patients belonging to risks group 1 and 2, but not to groups 3 or 4. the results of studies on risks, morbidity, and mortality in anaesthesia teach us that the human factor and technical error provoke complications, morbidity and mortality, seemingly unnecessarily. case history and a simple physical examination, primarily concentrated on respiration an ...	1988	3201916
determination of warm ischemia time at donor nephrectomy.	to assess the warm ischemia time of kidneys with obscure donor histories we attempted to develop an index for the duration of ischemia by analysis of adenine nucleotides and their degradation products in cortical biopsies of canine kidneys. two biopsy harvesting techniques were compared. the use of a laboratory technique (dentist's drill) resulted in higher concentrations of adenosine triphosphate (atp) in normoxic tissue specimens as compared with a clinical method of harvesting biopsies (wedge ...	1988	3276044
the effects of bulk versus particulate polymethylmethacrylate on bone.	twenty-one mature new zealand white female rabbits were allocated into three groups of seven rabbits. group i received a bolus of doughy simplex polymethylmethacrylate (pmma) cement injected into the proximal tibia through a drill hole. group ii received a preformed, cooled, bulk pmma pellet. group iii had particulate pmma powder implanted. the operated, but nonimplanted, left tibiae served as controls. animals were killed after four months. histologically, both group i and group ii demonstrated ...	1988	3289814
induction of callus formation by implants of bone morphogenetic protein and associated bone matrix noncollagenous proteins.	callus formation in the periosteal bone interface in response to bone morphogenetic protein (bmp) and associated bone matrix noncollagenous proteins (bmp/ncp) was investigated in mature adult rabbits. for controls byproducts of bmp/ncp purification, bone marrow, eight nonskeletal tissues, purified matrix gamma-carboxyglutamic acid-rich protein (mgp), and a composite of bmp/ncp and polylactic-polyglycolic acid polymer (pla/pga) were also implanted in the periosteal bone interface. quantitative mi ...	1988	3180578
algae-derived (phycogene) hydroxylapatite. a comparative histological study [corrected and issued with original paging in int j oral maxillofac surg 1988 oct;17(5)].	3 granular hydroxylapatite (ha) biomaterials, solid, coralline and phycogene ha (obtained from calcifying algae), differing widely in their relative amounts of specific surfaces and their origin, were examined with regard to their effects on bone healing in rats. trephine drill holes were produced in the rat femur and filled with the ha granules. each biomaterial produced a characteristic pattern of bone healing. bioceramics with a small surface area showed random bone-implant contacts. biomater ...	1988	3145947
limb lengthening by diaphyseal corticotomy, callus distraction, and dynamic axial fixation. an experimental study in the ovine femur.	limb lengthening of the left femur was performed in 12 sheep, 7-8 months of age. after weakening of the cortex by drill holes, a controlled fracture was created in the diaphysis. the bone segments were fixed in reduced position using a unilateral external fixation device. the fixator was left in neutral position for 10 days postoperatively when lengthening started. by means of daily distraction at a rate of 1.0 mm once a day for 3 weeks, an average lengthening of 1.9 cm (11.9%) was obtained. two ...	1988	3404330
fibrin sealant in orthopedic surgery.	the use of clotting substances from blood for hemostasis dates back to 1909. in 1972, modern fibrin sealing (fs) was developed in vienna. for application, the two components, i.e., a sealer protein solution (mainly fibrinogen) and a thrombin solution, are mixed to produce the fibrin clot. the sealant may be applied with a needle, as a spray, or by premixing (e.g., with antibiotics, bone chips) for subsequent sealant application in cavities. while the positive effect of fs in normal wound healing ...	1988	2448076
proposed digital arthroplasty critical study of the preliminary results.	in view of the results of swanson implants, particularly the long-term course of silicone implants, the authors studied and developed semi-constrained sliding arthroplasty designed for metacarpo-phalangeal and proximal interphalangeal joints. the preliminary study on bones and then on cadaver hands and finally on the knee of the rabbit allowed the design and experimentation of a prototype which led to the creation of a semi-constrained arthroplasty for which the elastic diaphyseal anchoring is e ...	1988	3233039
the effects of drilling on revascularization and new bone formation in canine femoral heads with avascular necrosis: an initial study.	in this study, the effects of drilling on revascularization and new bone formation were evaluated in nine dogs with surgically induced avascular necrosis (avn) of the femoral head. six animals had holes drilled from the greater trochanter into the femoral head at the time of vascular interruption. vital fluorescent bone stains were injected immediately postoperatively (calcein green). 6 weeks postoperatively (xylenol orange), and 12 weeks postoperatively (oxytetracycline). in the operative femor ...	1989	2481023
evaluation of the max titanium alloy retentive pins.	this study evaluated the max 017 retentive pin (.019 in./.48 mm) and its twist drill (.017 in./.43 mm) along with the max 021 pin (.024 in., .61 mm) and its twist drill (.021 in./.53 mm), in relation to shoulder stop position, space between the end of the pin and the end of the channel and the development of cracks in dentin adjacent to pin channels. a total of 20 non-carious human molar teeth were used, 10 for each size pin. four pins were placed in each tooth for a total of 40 of each size pin ...	1989	2638854
the indiana speech training aid (istra). i: comparisons between human and computer-based evaluation of speech quality.	experimental comparisons are reported between computer-based and human judgments of speech quality for the same sets of utterances. speech stimuli were recorded from two normal talkers, who intentionally varied the quality of their speech, and from a hearing-impaired child who was receiving speech therapy on the indiana speech training aid (istra). the tape recordings were submitted for evaluation to a naive jury, an expert jury, and the istra system, a microcomputer equipped with a speaker-depe ...	1989	2661917
[percutaneous partial diskectomy in the dog--an alternative to surgical disk fenestration].	a new, technically simple operation method for the fenestration of disks is described which was performed successfully on six experimental dogs on the thoracolumbar disks and did not stress them very much. a percutaneous partial diskectomy (ppd) of the anulus fibrosus and the nucleus pulposus with a bone drill (diameter 5 mm) is performed. the extracted cylinder bone allows a histological judgement of the disci intervertebrales. this method was applied to 10 animal patients with discopathia, and ...	1989	2763293
the effect of a penetrating biodegradable implant on the growth plate. an experimental study on growing rabbits with special reference to polydioxanone.	this study examined the fate of a biodegradable polydioxanone (pds) implant in growing bone in rabbits. in 20 immature rabbits, a pds rod 2.0 mm in diameter and 25 mm in length was driven into a drill hole of equal bore in the intercondylar portion of the right femur across the central portion of the growth plate. in another 25 immature rabbits, a pds rod 3.2 mm in diameter and 25 mm in length was driven into a corresponding drill hole using the same technique. the follow-up intervals were three ...	1989	2494011
[coronary atherectomy using a rotablator].	a system or rotary atherectomy (rotablator) was evaluated on coronary stenoses in man. this device consists of catheter presenting an abrasive olive-shaped knob at one end, and sliding over a central metallic guide, rotating at more than 150,000 tpm. this drill liquifies the atheroma in small microparticles able to cross the microcirculation. the atherectomy surface is perfectly smooth and the risk of thrombosis is minimum. the atherectomy technique is quite simple, similar to ptca, the balloon ...	1989	2589813
the effect of radial preload on the implant-bone interface: a cadaveric study.	the most common complication of external fixation is pin loosening. preloading the implant-bone interface is believed to retard this process. radial preload, in particular, may be useful, as it allows loading in more than one direction. to investigate the effect of varying degrees of radial preload on the pin-bone interface, 30 freshly thawed human cadaveric tibiae were sectioned into 4-cm segments. uniform drill holes were produced in the anterior tibial ridge of all segments and custom experim ...	1989	2600701
low cost device for removing human and small primate temporal bone plugs.	previously, only the expensive oscillating saw and schuknecht temporal trephine were available for removing human temporal bone plugs and no trephines were made for smaller research primates. an inexpensive hole saw has been modified for removing such plugs with an electric drill. this device is less expensive, easier to use, causes less potential impact damage to the plug, and the size of the hole saw can be varied for the size of the skull.	1989	2644182
walking through a human ear.	a computer animation system was developed to show the inside of a human ear as if the viewer were walking through it. a surface model of the human temporal bone was graphically reconstructed from serially sectioned celloidin specimens. in order to input the outline curves of ear structures, several reference marks were drilled into a celloidin block prior to sectioning. a sliding microtome was put on a worktable with a specially designed motor-driven drill. the machine made it possible to drill ...	1989	2756826
recurrent radial head subluxation treated with annular ligament reconstruction. a case report and follow-up study.	radial head subluxation secondary to traumatic rupture of the annular ligament has been well described in the literature. annular ligament reconstruction utilizing fascia lata graft has been proposed and described, but no follow-up reports have been published. a 21-year-old man was treated by annular ligament reconstruction for recurrent radial head subluxation with a good result and no recurrent subluxation at more than four years postoperatively. the operative technique is as follows: a fascia ...	1989	2766601
mycosis fungoides with fatal brain involvement.	the clinical course, therapy and investigations in a man with lichenoid mycosis fungoides which resulted in fatal spread to the brain is described. immunological studies revealed a significant reduction in t cell numbers. brain lesions were confirmed by ct scan and drill biopsy. the literature on the subject is discussed.	1989	2486175
transient changes in cyclic amp and in the enzymic activity of protein kinase and phosphorylase during the cardiac cycle in the canine myocardium and the effect of propranolol.	oscillation of cyclic amp and in the activity ratio of cyclic amp-dependent protein kinase and of glycogen phosphorylase with the cardiac cycle were demonstrated in the canine heart in situ. for tissue sampling an ecg (r-wave)-triggered, automatically working push-freeze-drill apparatus was developed which allows intraventricular cryobiopsies from the left ventricular muscle of anaesthetized open-chest dogs. the nucleotide cyclic amp oscillated with the cardiac cycle during normal working condit ...	1989	2554124
subclinical lumbar polyradiculopathy in aged domestic, laboratory, and exotic mammalian species--a light and selected electron microscopic study.	lumbar polyradiculopathy, characterized by ballooning myelin sheaths and axonal distortion, was documented in multiple, aged, domestic, laboratory, and exotic mammalian species. animals studied that exhibited this nerve rootlet change included the goat, sheep, pig, white-tailed deer, gerbil, vole, ferret, beaver, hedgehog, chinchilla, north chinese leopard, lion, cheetah, mountain lion, llama, east african eland, uganda giraffe, polar bear, and drill. ultrastructurally, lumbar nerve rootlets fro ...	1989	2766747
waterborne outbreak of campylobacter enteritis after outdoors infantry drill in utti, finland.	diarrhoea, abdominal pain, malaise and fever affected 75 of the 88 conscript soldiers in utti, finland after an outdoors infantry drill. campylobacter jejuni, heat-stable serotype 3/43/59, was isolated from 37 out of 63 men investigated. a clear serological response was evident in the risk group and negligible in the control group. the entire population at risk was interviewed. the outbreak was associated with the consumption of untreated surface water. c. jejuni, heat-stable serotype 3/43/59, w ...	1989	2776848
interactive radio instruction: developing instructional methods.	the usaid has, since 1972, funded the development of a new methodology for educational radio for young children through 3 projects: the radio mathematics project of nicaragua, the radio language arts project of kenya, and the radio science project of papua new guinea. these projects developed math programs for grades 1-4 and english as a second language for grades 1-3; programs to teach science in grades 4-6 are now being developed. appropriate techniques were developed to engage young childr ...	1989	12283103
sem study of surface alterations of bioactive glasses and glass--ceramics in a bony implantation bed.	back scattered electron (bse) images of glasses and glass-ceramics with different degrees of bone-bonding behaviour have been investigated. after the implantation of probes in the femur of rats changes of the surface material, induced by leaching and corrosion (material response) and of the tissue in the drill hole (host response), were studied. the results demonstrate advantages of using bse images and give further information for understanding the sequential changes in the implant material w ...	1990	10171196
indomethacin and bone trauma. effects on remodeling of rabbit bone.	the influence of indomethacin on remodeling activity in normal trabecular and cortical bone and its influence on cortical bone close to a midtibial drill hole, 2 mm in diameter were histomorphometrically evaluated. eight rabbits were treated with indomethacin (12.5 mg/kg/day), and another 8 rabbits served as controls. after 3 days, the mean plasma indomethacin level was 542 ng/ml, resulting in an almost complete inhibition of prostaglandin synthesis as reflected by the serum levels. in the contr ...	1990	2336956
[heat distribution within the bone tissue by rotary cutting instrument for imz implant. heat analysis by a real-time thermography].	a highly skilled surgical technic is an important factor for the success of implant. but the heat generation during bone preparation will greatly affect the healing process of bone and prognosis of implant. in this study, the heat occurrence and distribution during bone preparation which performed on an in vitro mandible model (ribs of pig) were considered with the aid of a real-time thermography. imz implant drills and bur, designed for cylindrical type implant were used for the bone preparatio ...	1990	2134919
the histological effects of the implantation of different sizes of polyethylene particles in the rabbit tibia.	this study examines the histological effects of different sizes of polyethylene particles implanted into the rabbit tibia. seventeen mature new zealand white female rabbits were allocated into three groups. group 1 (5 rabbits) received polyethylene particles averaging approximately 16 microns in diameter, implanted into the right proximal tibia through a drill hole. group 2 (5 animals) received particles averaging 26 microns, and group 3 (7 rabbits) received particles averaging 67 microns. the l ...	1990	2189880
prostaglandin e2 levels in the membrane surrounding bulk and particulate polymethylmethacrylate in the rabbit tibia. a preliminary study.	fourteen mature new zealand white female rabbits were allocated into two groups. group 1 received a bolus doughy simplex polymethylmethacrylate (pmma) cement injected into the proximal tibia through a drill hole. group 2 received an equal volume of particulate pmma cement powder. the operated but nonimplanted left tibiae served as controls. the animals were killed after four months. the membrane surrounding the implant area was harvested aseptically and grown in tissue culture. the supernatants ...	1990	2199124
laser doppler flowmetry and bone blood flow in an isolated perfused preparation.	a preparation of an isolated bovine forefoot was established which could be perfused with blood at variable rates. a laser doppler flowmeter probe inserted into the cancellous bone of the metatarsal produced a signal which varied with changes in perfusion rate and oscillated in synchrony with the peristaltic perfusion pump. a stronger laser doppler signal was obtained when the probe was inserted into a drill hole than when inserted into a hole bored with a guide wire. it appears that laser doppl ...	1990	2231667
inability of medroxyprogesterone acetate to down regulate estrogen receptor level in human breast cancer.	the influence of medroxyprogesterone acetate (mpa) on estrogen receptor (er) and progesterone receptor (pr) levels was studied in 20 postmenopausal patients with er-positive and pr-positive primary breast cancers. each patient underwent drill biopsy and subsequently mastectomy. the drill biopsy and surgical specimens were assayed for the total er and pr levels (cytosolic plus nuclear fraction) by enzyme immunoassay. between the drill biopsy and mastectomy, ten patients received no treatment (con ...	1990	2137722
the effects of bulk versus particulate titanium and cobalt chrome alloy implanted into the rabbit tibia.	twenty-eight mature new zealand white female rabbits were allocated into 4 groups of 7 rabbits. group 1 received a coiled wire of cobalt chrome alloy (vitallium) (16 gauge x 1 cm). group 2 received an equal weight of cobalt chrome particles averaging 15.4 microns in diameter. group 3 received a coiled wire implant of commercially pure (c.p.) titanium (16 gauge x 1 cm). group 4 received the same weight of c.p. titanium particles averaging 3.8 microns. the implants were placed through a drill hole ...	1990	2279985
structural consequences of transcortical holes in long bones loaded in torsion.	finite element models were used to predict the structural consequences of transcortical holes through long bones loaded in torsion. several parameters were investigated including hole size, anelastic behavior of the bone, cortical wall thickness, cortical wall symmetry, curvature along the bone's long axis and the axial length of the defect. finite element model predictions of percent intact bone strength were compared to experimental data for sheep femora with transcortical drill holes loaded t ...	1990	2292605
myocardial protective effects of lidoflazine during ischemia and reperfusion.	the myocardial protective effect of intravenous (i.v.) lidoflazine with potassium cardioplegia and hypothermia (28 degrees c) was investigated in 21 greyhounds. animals were injected a single dose of cardioplegia (30 ml/kg body weight) and subjected to 120 minutes of ischaemia and 60 minutes of reperfusion. ten dogs served as controls (group c) and 11 dogs received i.v. lidoflazine (1.25 mg/kg b.w.) (group l). myocardial drill biopsies for the adenosine triphosphate (atp) and the creatine phosph ...	1990	2309223
effects of clustered drill holes on the breaking strength of the equine third metacarpal bone.	the breaking strength (stress at failure) of equine third metacarpal bones, with and without clustered drill holes, was determined in vitro. paired ossa metacarpalia ii-iv of 39 horses (n = 39) between 2 and 7 years old were tested in palmarodorsal 3-point bending. four treatments were compared. clustered 2.7- or 3.5-mm drill holes, in a 4- or 7-hole pattern, were made in the dorsal cortex of the distal diaphysis of the left third metacarpal bone. undrilled right third metacarpi were used as con ...	1990	2386322
retrograde axonal transport of mercury in primary sensory neurons innervating the tooth pulp in the rat.	the pulp cavity of the first upper molar was exposed unilaterally in adult rats with a dental drill and about 1 microliter of mercuric chloride was injected into the coronal pulp. the rats were killed after 1-24 days and frozen sections from the trigeminal ganglia were subjected to silver acetate autometallography for demonstration of mercury. mercury was found to have accumulated in neurons of the ipsilateral trigeminal ganglion by retrograde axonal transport. the possible implications of this ...	1990	1699174
a comparison of manual and power-assisted thoracolumbar disc fenestration in dogs.	thoracolumbar disc fenestration was performed in eight canine cadavers. a hole was cut in the anulus fibrosus with a scalpel in four dogs, and with a high speed drill and burr in four dogs. a curette was used to remove as much of the nucleus pulposus as possible. sixty-five percent of the nucleus pulposus was removed with the power-assisted technique and 41% was removed by manual fenestration. manual and power-assisted disc fenestration were performed on alternate intervertebral discs from t11-1 ...	1990	2145687
laser assisted fixation of ear prostheses after stapedectomy.	three different lasers (erbium:yag, holmium:yag, alexandrite) were used to drill a hole at the end of the long process of the incus in order to fix an ear prosthesis after stapedectomy or small fenestra stapedectomy. the energy was coupled into a 250-microns core diameter zirconium-fluoride fiber. the operations were carried out on human temporal bone models from cadavers. the fiber was guided to the incus under the stereoscopic surgical microscope. the tissue response was examined under the sca ...	1990	2233098
effect of diethylcarbamazine on adult loa in monkeys.	the effect of diethylcarbamazine citrate (dec) treatment (43-150 mg kg-1 daily for 12-21 days) on adult loa worms in five drills (mandrillus leucophaeus) is described. in individual monkeys, between one-third and all of the adult worms survived the treatment, and most of the surviving females were still producing live microfilariae. these experiments provide direct evidence which may explain the common clinical experience that single courses of dec do not always succeed in eliminating the signs ...	1990	2260903
[acid-base equilibrium values in the blood of dogs during training and work stress].	separate components of acid-base balance in blood (abr)-ph, pco2, be, sb, bb-were studied during the long-term drill of service dogs of two age categories. these service dogs were included in two different work strain groups (patrol dogs and searching dogs). the results of long-term drill demonstrated, in particular, significant changes in dynamics of ph and pco2. the ph values were permanently raised as compared with reduced pco2 values during the whole period of 130-days exercise and as compar ...	1990	2102583
hole preparation techniques for transpedicle screws. effect on pull-out strength from human cadaveric vertebrae.	in each of eight thoracolumbar human cadaveric vertebrae, a hole was made through one pedicle into the vertebral body with a drill bit and through the contralateral pedicle with a probe. identical metal screws were implanted into the holes to equal depths, and maximum pull-out force was determined for each screw. using a paired student t test, no significant difference (p = 0.87) was found in pull-out strength between the screws implanted into drilled holes and those implanted into probed holes. ...	1991	2011773
compartment syndrome after closed intramedullary nailing of the tibia: a canine model and report of two cases.	two patients developed an anterior tibial compartment syndrome after closed reamed intramedullary nailing of their fractured tibial shaft. subsequently, a study was undertaken using a canine model to evaluate the risk of compartment syndrome after this operative procedure. a closed tibial fracture was created in 20 mongrel canines by applying a torsional load localized to the tibial shaft through a stress riser made with an intramedullary drill. compartment pressures were measured in the canine ...	1991	2023047
[an experimental verification of the thermal changes in the bone tissue during drilling for cavity preparation for an endosseous implant].	the local temperature increase of the bone following drilling procedures has been evaluated. without any cooling device, and using a standard-speed drill, in few seconds the temperature reaches the necrosis-limit for living tissues (55 celsius degrees). we compared the effectiveness of the most common cooling methods involving a forced flow of saline reaching the bone through an axial canal in the drill or just applied to the external surfaces of drill and bone with that of a device allowing a 1 ...	1991	2041537
stabilization of bilateral sacroiliac fracture-luxations in small animals with a single transsacral screw.	bilateral sacroiliac fracture-luxations in four dogs and four cats weighing 3.5 kg to 30.9 kg were reduced and stabilized with a single 3.5 mm, 4.5 mm, or 6.5 mm transsacral screw. alignment of the drill bit was visual in six cases and assisted by the use of an aiming device in two cases. seven animals were reevaluated at months 3 to 6. no significant screw loosening or loss of reduction had occurred. although no intraoperative complications were encountered with visual drill bit alignment, use ...	1991	2042287
bone biopsy in the horse. 1. method using the wing of ilium.	two hundred and five bone biopsies from the wing of ilium were taken from 52 growing and 70 older horses. the method was initially evaluated in 4 horses at post mortem and then performed in 26 horses under general anaesthesia. the technique was later developed for biopsying horses in the standing position under local anaesthesia (n = 70 adults; n = 22 foals). the core of the bone biopsy consisted of a central cancellous portion between two cortices. this type of sample allowed a complete histomo ...	1991	1796680
ankylosing spondylitis in nonhuman primates: the drill and the siamang.	nonhuman primates are known to be susceptible to many of the arthritides that afflict humans. psoriatic like spondyloarthropathies have been reported in gorillas and skeletal hyperostosis in gibbons, rhesus monkeys, and gorillas, and additional cases of both of these conditions occurring in drills (baboons) are noted in this report. one western lowland gorilla and two rhesus monkeys with clinical features consistent with ankylosing spondylitis have been documented previously. two additional nonh ...	1991	1788553
suppression of prostaglandin e2 synthesis in the membrane surrounding particulate polymethylmethacrylate in the rabbit tibia.	fifteen mature, new zealand, female rabbits were divided into two groups. using sterile technique, a 6-mm drill hole was made in the tibia 1 cm distal to the knee joint bilaterally. the marrow was scooped out underneath the hole. the right tibia received simplex particulate cement polymer and the left leg functioned as a prepared, but nonimplanted, control. all animals were fed a standard diet. whereas the six animals in group 1 received regular water, the nine animals in group 2 drank water in ...	1991	1914312
[morphological studies for the objective determination of a linear direct drill channel for standardized reconstruction or replacement of the anterior cruciate ligament].	in 30 definitive positioned, human, cadaver knee joints a single linear drill pass, in direction of the anterior cruciate ligament, suitable for reconstruction or replacement, was installed by the help of a drill guide through femur and tibia. morphometric data of knee joints and drill passes underwent correlation- and regression analysis which showed, that the superficial drill holes in femur and tibia could be described by four functions to fix the course of a single linear drill pass individu ...	1991	1805665
human nail dust: hazard to chiropodists or merely nuisance?	this survey was carried out in response to anxiety among chiropodists as earlier reports had raised the possibility of respiratory damage as a result of sensitization to trichophytons. questionnaires were sent to 327 chiropodists and 168 replies were received. the aim was to investigate respiratory symptoms and their relationship to work and drill usage. all of those completing questionnaires were invited to attend the occupational health department for prick tests and lung function tests. just ...	1991	1921341
longitudinal crack propagation in bone around femoral prosthesis.	intraoperative femoral fracture is a well-recognized technical complication of cementless total hip arthroplasty. this study was designed to establish an in vitro model for initiation and propagation of fractures of the proximal femur in cementless tha and to assess the effect of fracture fixation in the form of cerclage wiring and drilling a hole in the distal extent of the fracture line. fourteen human anatomic femur specimens were studied. longitudinal cracks were made and propagation was per ...	1991	1934730
[life style of schoolchildren in frederiksberg].	in 1989, a total of 674 pupils in the sixth and eighth grades in nine municipal schools in the municipality of frederiksberg replied to a questionnaire containing questions about health knowledge and behaviour. the behaviour of the pupils as regards tobacco, alcohol, diet, exercise, sleep, traffic, employment of medicine and general health were compared. in the sixth grade, 16% of the pupils and 48% of the pupils in the eighth grade had somewhat unsuitable behaviour as regards more than three of ...	1991	1949285
the history of the neurosurgical engine.	the opening of the skull of a living human being dates back to early civilization. the procedure may have been performed as early as the neolithic period. surgeons have continued to search for a better, easier, quicker, and safer method to open the skull. today, most neurosurgeons are well acquainted with the surgical drill; however, few are familiar with the development of this instrument from its beginnings in dentistry to its use in modern neurosurgery. as cerebral localization advanced in th ...	1991	1994266
local demineralization as a model for bone strength reductions in lytic transcortical metastatic lesions.	the structural consequences of bone density changes associated with lytic metastatic lesions were investigated using an experimental model of regular, lytic metastatic lesions in bone. circular holes were drilled in the mid-diaphyseal cortex of paired adult canine femora. the region around the defect was demineralized in one bone of each pair with 0.8 n hcl. specimens were tested to failure in four-point bending. defect size was determined from conventional planar radiographs as the maximum appa ...	1991	1743916
[experimental study on hydroxyapatite soaked in sodium fluoride--with special reference to bone formation].	an experimental comparative study on bone formation regarding surface implantation was performed on thirty three adult mongrel dogs; using either a hydroxyapatite soaked in sodium fluoride (f-hap) or a hydroxyapatite (hap). f-hap was made as follows: the hap was soaked in 100ml of sodium fluoride solution of 5ppm., 10ppm. and 100ppm. concentration for an hour under vacuum deaeration+. under general anesthesia, specimens were implanted into the bone immediately inferior to tibial tubercle by open ...	1991	1787344
experimental ligament reconstruction by allogeneic tendon graft in a canine model.	the revascularization and remodelling of fresh-frozen allografts used to replace the anterior cruciate (acl) and medial collateral ligaments (mcl) of the knee were studied by microangiographic, histological and biomechanical methods. the allografts were produced from the patellar tendons of dogs. no bone was attached on either end. the tissue was frozen and thawed immediately before grafting. the grafts were shaped to either 4 to 4.5 mm (for acl or mcl) or 8 to 9 mm wide (for acl), and fixed int ...	1991	1792884
loss of strength in drilled bone in orthopaedic surgery.	it is common practice in orthopaedic surgery to drill holes in bones for the placement of screws. such holes make the bone weaker compared to an intact one. the loss of strength after drilling holes in the compact bone is studied here.	1991	1843123
bone morphogenesis of rabbit bone morphogenetic protein-bound hydroxyapatite-fibrin composite.	hydroxyapatite (hap) and fibrin have been implanted in patients and observed to be well tolerated in orthotopic sites. this is a report on a composite of hap, fibrin, and rabbit bone morphogenetic protein and insoluble noncollagenous protein (bmp-incp). drill holes in the femoral condyles of rabbits were packed with granulated hap (200 mg), fibrin (0.3 ml), bmp-incp (5 mg), or various combinations of the two. the fibrin consisted mainly of sterilized human fibrinogen and thrombin, and bmp-incp w ...	1991	1847098
external fixator pin insertion techniques: biomechanical analysis and clinical relevance.	a series of identically matched pairs of fresh-frozen canine femora (approximating human radii in size and dimension) were used to mechanically compare pull-out strength between 4 mm predrilled, self-tapping, half-pins and 4 mm self-drilling, self-tapping half-pins with drill bit-like cutting flutes. a second biomechanical and videotape analysis was done comparing the differences of pin insertion by power versus hand drilling. results indicated a mean 22% reduction in bone purchase of self-drill ...	1991	1861045
modulation of the membrane surrounding particulate cement and polyethylene in the rabbit tibia.	twenty-nine mature new zealand white, female rabbits were divided into four groups. using sterile technique, a 6 mm drill hole was made in the tibia 1 cm distal to the knee joint. the marrow was scooped out underneath the hole. the right tibia received simplex particulate cement polymer (pmma) (groups 1 and 2) or polyethylene particles (uhmwp) (groups 3 and 4). the left leg functioned as a prepared but non-implanted control. all animals were fed a standard diet; those in groups 1 and 3 received ...	1991	1878453
quantitative comparison of the histological effects of particulate polymethylmethacrylate versus polyethylene in the rabbit tibia.	fourteen mature female new zealand white rabbits underwent implantation of simplex polymethylmethacrylate (pmma) powder or particulate (average 67 microns) ultrahigh-molecular-weight polyethylene (uhmwpe) through a drill hole in the proximal right tibia. the left tibia functioned as a prepared but nonimplanted control. animals were killed after 16 weeks. histological examination of the bone-implant interface in the particulate pmma group disclosed a florid foreign-body reaction with the presence ...	1991	2059533
a method for rapid implantation of multielectrode systems.	the implantation of several chronic electrodes at the same time was needed for the studies in which both evoked slow potential and multiple unit neural activity of different brain sites were recorded during classical conditioning in freely moving cats. the recording electrodes were made of 25-75 microns insulated stainless steel or nichrome wires which were inserted into a thin hypodermic needle of a fixed, calibrated length. the fast implantation system described here is based on the use of a s ...	1991	2062914