Publications

[inflammatory occlusion of the lacrimal and nasal pathways caused by monosporium apiospermum (allescheria boydii)].		1982	6892039
non-aspergillus aspergilloma.	a case of lung cavity with fungus ball is reported in a patient subsequent to the treatment of tuberculosis for a year. fungal serologic titers for histoplasmin, blastomycin, coccidiodin, and aspergillin were negative. surgical resection of the cavity and to be done because of episodes of hemoptysis. numerous hyphae formed into a compact mass consistent with aspergilloma were seen in the cavity. the cultures for fungi were negative on material from the surgical specimen. immunodiffusion studies ...	1982	7148753
conidiogenesis in petriellidium boydii (pseudallescheria boydii). a light and electron microscope study.	slide cultures of the type strain of p. boydii shear, showed percurrent production of conidia by light microscopy over a period of several hours. scanning and transmission electron microscopy were used to examine the conidiogenesis. the conidiogenous cells developed annular ridges rather than typical annellophoric scars. evidence that these ridges represented sequential spore production was shown by t.e.m. in the form of a discontinuity of the outer conidiophore wall at the widest point of each ...	1982	7121559
the histopathological features of pale grain eumycetoma.	histological findings in 24 cases of pale grain eumycetoma have been compared. the inflammatory response and morphology of grains caused by different organisms are very similar. however the histological appearances of neotestudina rosatii infections, although reminiscent of dermatophyte mycetomas, are distinctive. the characteristic features include the presence of cement and the short swollen hyphal segments. petriellidium boydii grains are more likely to contain numerous vesicles or swollen hy ...	1982	7164152
[maduromycotic mycetoma in a horse].	a case of maduromycotic mycetoma (eumycetoma) in seven years old draught horse is described. the disease was localized in anal region and healed after surgical treatment. attention is drawn to the necessity of distinguishing three types of mycosis in horses, characterized by the origin of tumor lesions - mycetomas, hyphomycosis and entomophthoromycosis - and information was gathered on their etiology and geographical occurrence. on the basis of the morphology of fungal elements traced in inflamm ...	1982	6801842
maxillary sinusitis from pseudallescheria boydii. efficacy of surgical therapy.	pseudallescheria boydii is a ubiquitous mold of soil and is a frequent cause of mycetoma in the united states. involvement of the sinuses is extremely rare. the necessity of medical and/or surgical management is largely unknown but appears to be dependent on variables of host defense mechanisms, as the fungus is relatively avirulent. chronic maxillary sinusitis secondary to p boydii developed in a noncompromised woman. evidence of erosion of the bony wall of the orbit was encountered at operatio ...	1983	6849666
development of fluorescent-antibody reagents for demonstration of pseudallescheria boydii in tissues.	we prepared fluorescent-antibody reagents to detect and identify pseudallescheria boydii in tissue. antisera to broken mycelium and condidia (particulate antigens) and to culture filtrates (soluble antigens) of p. boydii were produced in rabbits. antisera and globulin fractions of the antisera were labeled with fluorescein isothiocyanate and evaluated for their ability to stain p. boydii in tissues. the conjugates were first tested with cultures of 25 p. boydii isolates and 26 heterologous fungi ...	1983	6195179
pseudallescheria boydii infection after bone marrow transplantation.		1983	6309050
detection of fungi in cerebrospinal fluid.	with the exception of cryptococcus neoformans, fungi are rarely detected in cerebrospinal fluid obtained from patients having or suspected of having fungal meningitis. a review of the literature reveals that several fungi have been either isolated, observed, or both in cerebrospinal fluid specimens. these fungi include acremonium species, aspergillus amstelodami, a. flavus, a. fumigatus, a. oryzae, a. terreus, blastomyces dermatitidis, candida albicans, c. tropicalis, c. viswanathii, coccidioide ...	1983	6349340
exoantigen tests for the immunoidentification of fungal cultures.	exoantigen tests for the immunoidentification of fungal pathogens are playing a new and significant role in the diagnostic laboratory. properly performed and controlled exoantigen tests lead to rapid, accurate identification of cultures of many fungal pathogens. the tests are particularly valuable in identifying dimorphic pathogens that are difficult to convert or with atypical cultures. we review the value of exoantigen tests for identifying mycelial form fungi: aspergillus spp. blastomyces der ...	1983	6410243
an ultrastructural study of pale eumycetoma grains.	the electron microscopic appearances of grains from seven patients with pale grain eumycetoma infections have been studied. the infecting fungi were pseudallescheria boydii (2), fusarium sp. (1), acremonium kiliense (1), a non-sporing mould (2) and trichophyton violaceum (1). p. boydii grown in vitro and grains from a madurella mycetomatis infection were used for comparison. the most important ultrastructural features of the pale eumycetoma grains were the gross thickening of the fungal cell wal ...	1983	6686344
antifungal agents used in systemic mycoses. activity and therapeutic use.	the development of the polyene antibiotic, amphotericin b, provided for the first time a drug which was clinically effective in many serious mycotic diseases. unfortunately, it requires parenteral administration and is often toxic, factors which limit the total cumulative dose which can be given. efforts to utilise combinations of amphotericin b with other agents were best realised with amphotericin b/flucytosine in cryptococcal meningitis, and to a lesser degree in systemic candidiasis. more re ...	1983	6297871
[case of thoracic empyema due to petriellidium boydii (allescheria boydii)].		1983	6686265
petriellidium (allescheria) boydii mycetoma in an immunosuppressed host.		1983	6357546
petriellidium (allescheria) boydii orbital and brain abscess treated with intravenous miconazole.	a previously healthy 4-year-old boy suffered a penetrating injury to his left orbit and left frontal lobe, which resulted in an infection by petriellidium boydii. the patient was successfully treated with intravenous miconazole and multiple debridements.	1984	6731542
petriellidium boydii pachymeningitis treated with miconazole and ketoconazole.	a very rare case of petriellidium boydii pachymeningitis is described. rarer still is the stabilization of this case for a prolonged period. miconazole and ketaconazole both seemed useful in the treatment, and their role is discussed.	1984	6324020
disseminated petriellidiosis (allescheriasis) in a patient with refractory acute lymphoblastic leukaemia.	a case of disseminated petriellidiosis is presented. this complication occurred in a patient with refractory acute lymphoblastic leukaemia, who was receiving repeated courses of cytotoxic drugs, antibiotics and prolonged corticosteroid therapy. the diagnosis of infection by petriellidium boydii was established by pathological and microbiological studies of a specimen obtained at open lung biopsy. the portal of entry was probably through the lung spreading later via the blood stream to the brain, ...	1984	6584444
petriellidosis (pseudallescheriasis) in southwestern ontario, canada.	seven cases of petriellidosis (pseudallescheriasis) in southwestern ontario residents and one in a saskatchewan patient are recorded. brief clinical histories are given of two of these cases. the first isolation of petriellidium boydii from soil in ontario is also described.	1984	6463808
pseudallescheria boydii in a patient with acute lymphoblastic leukemia.	pseudallescheria boydii, a common soil organism, is best known as the causative agent of mycetoma. isolation of the organism from sites other than the extremities is relatively uncommon. however, the use of corticosteroids and cancer chemotherapy has been associated with an increasing frequency of localized superinfection as well as disseminated disease. recently, an increased number of disseminated p boydii infections, primarily associated with immunosuppressed patients, has been reported in th ...	1984	6588928
brain abscess due to petriellidium boydii.	a 22 year-old man died from multiple cerebral abscesses due to petriellidium boydii 4 1/2 months after an episode of near drowning. the autopsy showed dissemination to heart and kidney. this patient had no immunocompromising disease but was treated with corticosteroids. the treatment of this condition with ventricular shunting and amphotericin b is discussed and compared with the experience of ten other cases reported in the literature.	1984	6467093
fungal sinusitis in healthy and immunocompromised individuals.	clinical and microbiologic aspects of fungal sinusitis occurring in six patients are presented. three of the six patients were immunosuppressed. fatal disseminated fungal disease developed in two of those immunosuppressed. the three patients with normal immune function had fungal infections confined to the nasal sinuses. aspergillus fumigatus and aspergillus flavus were recovered from the immunosuppressed patients and sporothrix schenckii, alternaria species, and pseudallescheria boydii were rec ...	1984	6496403
pulmonary, cardiac, and thyroid involvement in disseminated pseudallescheria boydii.		1984	6548359
pseudallescheria boydii infections treated with ketoconazole. clinical evaluations of seven patients and in vitro susceptibility results.	seven patients infected with pseudallescheria boydii were treated with oral ketoconazole, 200 to 600 mg/day for one to 13 months. five patients had pulmonary infections; two had skeletal infections. improvement of pretreatment abnormalities occurred in five patients, one of whom had concurrent arthrodesis of his infected knee. the other two patients were subsequently healed by surgical resection of their pulmonary lesions. ketoconazole appeared less active than miconazole against 22 clinical iso ...	1984	6086243
in vitro susceptibility studies with oxiconazole (ro 13-8996).	oxiconazole (ro 13-8996) is a recently described imidazole derivative intended for topical use. 128 isolates of pathogenic fungi were tested in vitro against oxiconazole, miconazole, and ketoconazole using an agar dilution method. results indicated that miconazole was markedly more active than either oxiconazole or ketoconazole against candida albicans while ketoconazole was the more active compound against candida parapsilosis. a species specific difference in the susceptibilities of isolates o ...	1984	6086246
case report: prosthetic valve endocarditis caused by pseudallescheria boydii and clostridium limosum.	this report describes a patient with a combined infection due to pseudallescheria boydii and clostridium limosum on a prosthetic dura mater aortic valve homograft. while this patient had c. limosum only growing in blood cultures, both organisms were isolated from the surgically resected aortic valve. because p. boydii is generally resistant to amphotericin b but susceptible to miconazole, accurate differentiation of p. boydii from other fungi which may appear similarly in tissue sections (e.g., ...	1985	3990765
pseudallescheria boydii (petriellidium boydii) infection of the orbit.	a 10-year-old male developed a chronic orbital infection following penetrating trauma and retention of an orbital foreign body. diagnosis of infection with pseudallescheria boydii (petriellidium boydii) was made by fungal smear and culture. sensitivity tests indicated the organism was resistant to amphotericin b. surgical debridement of the inferior orbit and removal of the foreign body was followed by a six-week course of intravenous miconazole. the patient has shown no signs of recurrence in a ...	1985	4011116
miconazole therapy in pseudallescheria boydii infection.		1985	3835956
clinical significance of pseudallescheria boydii: a review of 10 years' experience.	pseudallescheria boydii is a recognized cause of mycetoma, a chronic fungal disease that usually affects the extremities. isolated case reports have also implicated p. boydii in infections of other sites. we report the first large series (83 isolates) of p. boydii in 46 patients, including the second report of p. boydii brain abscess and disseminated infection in a noncompromised host. between 1974 and 1984 at our institution, p. boydii was cultured from a variety of sites: respiratory tract, 36 ...	1985	3894816
brain abscesses due to pseudallescheria boydii associated with primary non-hodgkin's lymphoma of the central nervous system: a case report and literature review.	a 54-year-old man with primary non-hodgkin's lymphoma of the thoracic spinal cord developed multiple brain abscesses caused by pseudallescheria boydii. the patient had received radiotherapy and corticosteroid treatment before developing the brain abscesses. antemortem diagnostic evaluations were inconclusive, and diagnosis was finally made from postmortem brain specimens by the use of histologic examination and isolation of the fungus in culture. the portal of entry for the organism was unknown, ...	1985	4001716
an additional case of pulmonary pseudallescheria boydii improved with ketoconazole therapy.		1985	3996080
systemic pseudallescheriasis in a patient with acute myelocytic leukemia.	presented is a case of widely disseminated systemic pseudallescheriasis in a 41 year old male with acute myelocytic leukemia. the immediate cause of death appeared to be due to an extensive invasion of the lungs which showed massive intra-alveolar hemorrhages, congestion, mycotic thrombi, and multiple fungal lesions in all lobes. pseudallescheria boydii was diagnosed histopathologically by virtue of its characteristic conidia present in miliary lesions throughout a wide range of host's tissues, ...	1985	3859751
[mycetoma caused by petriellidium boydii: treatment with ketoconazole].	a case of mycetoma of the lower leg (madura foot) with bone involvement caused by petriellidium boydii is presented. after an initially favourable therapeutic response to ketoconazole (2 x 200 mg/die) the process recurred despite proven sensitivity of the fungus in vitro. it could not be controlled with conservative treatment and ultimately necessitated amputation of the lower leg. a striking, hitherto unreported feature of mycetoma was the episodic occurrence of circulating immune complexes wit ...	1985	4044257
successful medical treatment of pulmonary petriellidiosis.	we have reported a case with culture and serologic evidence of pulmonary infection with petriellidium boydii treated with intravenous miconazole, resulting in dramatic symptomatic improvement, stabilization of x-ray changes, and clearing of petriellidium on sputum culture. although no biopsy was done to establish absolute diagnosis of invasive disease, and thus the results of this case cannot be taken as an absolute criterion for therapy, this may represent the first medical cure of pulmonary in ...	1985	4039074
post-craniotomy wound infection caused by pseudallescheria boydii. case report.	the authors describe the first reported case of post-craniotomy wound infection due to pseudallescheria boydii. the patient was a 24-year-old man who sustained a direct blunt injury to the calvaria, resulting in a large subdural hematoma that was surgically evacuated. subsequently, the surgical wound became infected with a fungus, p. boydii, and was successfully treated with intravenous miconazole.	1986	3941340
nasal granuloma caused by pseudallescheria boydii.		1986	3698957
endogenous pseudoallescheria boydii endophthalmitis. a clinicopathologic report.		1986	3488853
pseudallescheria boydii infection of the central nervous system in a cardiac transplant recipient.	we have described a cardiac transplant recipient with fatal pseudallescheria boydii infection of the central nervous system. unusual features included meningitis without brain abscess and noncommunicating hydrocephalus due to exuberant growth of the organism in the ventricular fluid. long-term amphotericin b administration may have played a role in the development of this infection.	1986	3513333
pseudallescheriasis in northern britain.	five cases of pseudallescheria boydii infection are reported from the northern part of the united kingdom. none of the patients had travelled abroad. three cases of otitis in which p. boydii was associated with bacterial infections were diagnosed within a 6-month period. a lady who had diabetes mellitus presented with a pulmonary fungus ball in a pre-existent cavity caused by a previous bacterial infection. after minor trauma at the site of an old skin graft, a farmer's wife developed an ulcer o ...	1986	3097296
invasive aspergillosis diagnosed by immunohistochemistry with monoclonal and polyclonal reagents.	therapies differ for invasive infection due to the various filamentous fungi. however, histopathologic identification of aspergillus, pseudallescheria, fusarium, trichosporon, dematiacious hyphomycetes, candida, and zygomycetes may be confused, and microbiologic isolation is often delayed. to improve diagnosis, we examined the utility of polyclonal and monoclonal antibodies to identify aspergillus organisms by peroxidase immunohistochemical techniques. tissues obtained from 68 infected patients ...	1987	3308679
eumycotic mycetoma: review and report of a cutaneous lesion caused by pseudallescheria boydii in a horse.	a cutaneous mass (1.5 cm in diameter) was removed from the head of a horse and was diagnosed histologically as eumycotic mycetoma. immunofluorescence, performed on formalin-fixed, paraffin-embedded tissue, identified pseudallescheria boydii as the etiologic agent. findings from earlier reports of eumycotic mycetoma were compared with those of this horse.	1987	3319985
pseudoallescheria boydii soft tissue abscess.	pseudoallescheria boydii, a fungus often isolated from soil, commonly causes a mycetoma. successful treatment involves resection of the infected area and appropriate antifungal chemotherapy. in vitro sensitivity of p. boydii to miconazole is usually demonstrated, but resistance to amphotericin b and 5-fluorocytosine is often observed. limited data are available on the treatment of this infection with ketoconazole. an usual case of nontraumatic p. boydii soft tissue infection without draining sin ...	1987	3802640
treatment of pseudallescheria boydii infection with oral ketoconazole and topical miconazole.		1987	3426479
multiple mycetomas due to pseudallescheria boydii.	a patient with pulmonary sarcoidosis had evaluation of hemoptysis. a ct scan of the chest showed bilateral upper lobe cavities and five separate mycetomas with air-crescent signs. bronchial washings were positive on stains for fungal elements, and all cultures grew pseudallescheria boydii. we have not seen a previous report of multiple fungus balls due to p boydii demonstrated by chest ct.	1987	3576275
leucocyte chemotaxis to mycetoma agents--the effect of the antifungal drugs griseofulvin and ketoconazole.	polymorphonuclear leucocytes are the predominant cell type in the inflammatory infiltrate around mycetoma grains. human leucocyte chemotaxis using cells from healthy subjects has been demonstrated using cytoplasmic antigens from 3 mycetoma agents: madurella mycetomatis and pseudallescheria boydii, both fungi, and streptomyces somaliensis, an actinomycete. there was a statistically insignificant increase in chemotaxis in the presence of ketoconazole, but griseofulvin was a potent inhibitor of leu ...	1987	3617197
[epidemiologic study of mycetomas in mexico. apropos of 502 cases].	the epidemiological data of 502 mycetomas studied in the department of mycology, "centro dermatológico pascua", mexico city, were analysed. mycetomas prevail in males (79.7%), they are more frequent between 16 and 45 years of age (75%) and among rural workers (62.5%); they preferentially affect lower limbs (62.5%); these data are generally similar to the known publications on the matter. actinomycetomas are the most frequent with 97.2% of the cases, distributed as follows: nocardia: 85.6% among ...	1987	3621395
biotyping of micelial fungus cultures by the killer system.	based on the occurrence of the yeast killer phenomenon in hyphomycetes, the toxic effect of 37 selected killer yeasts was studied on eleven strains of pseudallescheria boydii, six strains of aspergillus niger, 18 strains of penicillium camemberti and nine strains of sporothrix schenckii. the demonstration of different biotypes within the species of p. boydii and p. camemberti proves that the killer system also is a practical and effective method for epidemiological studies among hyphomycetes. ba ...	1987	3653352
postcraniotomy mycetoma of the scalp and osteomyelitis due to pseudallescheria boydii.		1987	3655408
pseudallescheria boydii arthritis and osteomyelitis in a patient with cushing's disease.	pseudallescheria boydii infection involving the left distal femur and knee joint developed in a patient with cushing's disease, and recurred after treatment with both intravenous miconazole and intravenous amphotericin b. the patient subsequently had synovectomy and arthrodesis, and received ketoconazole, 600 mg per day orally for one year. concurrent with the start of ketoconazole, a bilateral adrenalectomy was done to control endogenous hypercortisolism. the patient's infection then resolved, ...	1987	3798191
fungal endocarditis caused by pseudallescheria (petriellidium) boydii in an intravenous drug abuser.	we present a case of fungal endocarditis in a 42-year-old man with a history of intravenous drug abuse who required aortic valve replacement for severe aortic insufficiency. cultures of the resected valve grew pseudallescheria boydii. the patient subsequently developed persistent endocarditis of the prosthetic valve with systemic embolism. at autopsy, cultures of the prosthetic valve grew monosporium apiospermum, an anamorph of pseudallescheria boydii. although fungal endocarditis is not uncommo ...	1987	15227321
pseudallescheria boydii mycetoma in northern new england.	mycetoma is a chronic subcutaneous fungal infection characterized by tumefaction, draining sinuses, and grains. it is most common in the tropics but occasionally occurs in the united states. we report a case of a mycetoma affecting the foot of a 38-year-old mentally retarded man from northern new england. the causal organism was identified as pseudallescheria boydii, the most common cause of mycetoma in the united states. the patient showed a partial response to 8 months of ketoconazole therapy.	1988	3229880
eumycotic mycetoma caused by pseudallescheria boydii in the abdominal cavity of a dog.	an abdominal eumycotic mycetoma with multiorgan dissemination was diagnosed in a 2-year-old dog. clinical signs included fever, vomiting, diarrhea, weight loss, and a palpable abdominal mass. the dog developed disseminated intravascular coagulation and died. pseudallescheria boydii was isolated from the abdominal mass, liver, and peritoneal fluid. relevant history included an ovariohysterectomy when the dog was 6 months old, which was complicated by dehiscence of the incision site and eviscerati ...	1988	3343183
pseudallescheria boydii brain abscess. complication of an intravenous catheter.	an adult patient survived a brain abscess with pseudallescheria boydii. she received intraventricular miconazole, 20 mg every 72 hours (minimal inhibitory concentration = 0.4 microgram/ml), and surgery. the abscess resulted from an infected central venous catheter (port-a-cath) and steroid therapy. miconazole caused a ventriculitis. there are 12 reported cases of p. boydii brain abscesses from 1965 to 1985 with only two survivors.	1988	3407662
bilateral pseudallescheria boydii endophthalmitis in an immunocompromised patient.		1988	3282394
in vitro interactions between blastomyces dermatitidis and other zoopathogenic fungi.	the results of in vitro interactions between colonies of blastomyces dermatitidis and six other zoopathogenic fungi are reported. the interactions were found to range from neutral with histoplasma capsulatum and candida albicans to strongly antagonistic with microsporum gypseum, pseudallescheria boydii, and sporothrix schenckii, and including lysis by cryptococcus neoformans. these observations suggest that interactions between zoopathogenic fungi may be one of the biotic factors likely to influ ...	1988	3058276
eumycotic mycetoma caused by pseudallescheria boydii in a dog.	abdominal eumycotic mycetoma caused by pseudallescheria boydii was diagnosed in a 3-year-old male siberian husky. the dog was examined because of weight loss and signs of depression. initially, pyrexia was the only clinical finding. antibiotic and corticosteroid treatment was ineffective. two weeks later, the dog's appetite had decreased, it had vomited a few times, and the caudal portion of the abdomen was sensitive to palpation. hematologic and serum biochemical abnormalities consisted of anem ...	1989	2466820
etiological agents of otomycosis in nigeria.	a total of 159 suspected cases of otomycosis comprising 101 adults and 58 children, 61 males and 98 females were investigated. of these, 36 cases were confirmed specifically of mycotic etiology on the basis of microscopic demonstration of fungal structures in epithelial debris/plugs and positive culture. another 31 cases positive for fungi by culture but negative for direct microscopy were considered of doubtful fungal etiology. the predominant etiological agents in the confirmed cases were aspe ...	1989	2503721
organ-specific variation in the morphology of the gungomas (fungus balls) of pseudallescheria boydii.		1989	2589943
studies on mycotic keratitis.	one hundred and fifty cases of corneal ulcers from the government ophthalmic hospital, madras, were investigated during 1980-1982 for the mycoflora. 68 cases (45%) were positive for fungi, comprising species of aspergillus (36 cases), penicillium, fusarium (8 cases each), curvularia (4 cases), candida albicans and mucor (3 cases each), drechslera (2 cases) and cladosporium, cephalosporium, pullularia, and allescheria boydii (1 case each). incidence of these fungi in mycotic keratitis is correlat ...	1989	2615780
actinomycotic intracavitary lung colonization.	we describe four cases of actinomycotic intracavitary lung colonization and review the literature on the subject. aspergillus fumigatus, a. niger, a. flavus, pseudallescheria boydii are responsible for the majority of fungi intracavitary lung colonization (fungus ball). the similarities in clinical symptom (haemoptysis) and radiologic feature (pulmonary air meniscus) of fungus ball and actinomycotic intracavitary colonization prompted the investigation into a range of microorganisms, including n ...	1989	2615797
potted plants in hospitals as reservoirs of pathogenic fungi.	the soils of five potted plants cultivated within a hospital were investigated for the presence of fungal opportunistic pathogens of humans. a total of 16 potentially pathogenic species were isolated, including aspergillus fumigatus at up to 53.5 colony-forming units (cfu) per gram dry soil and scedosporium apiospermum (pseudallescheria boydii) at up to 97.0 cfu/g. other common species included phialophora verrucosa and fusarium solani. scedosporium inflatum, a recently described emerging pathog ...	1989	2671744
pseudallescheria boydii brain abscess: association with near-drowning and efficacy of high-dose, prolonged miconazole therapy in patients with multiple abscesses.	brain abscess caused by pseudallescheria boydii is a highly lethal infection, usually seen in immunosuppressed patients. five patients with p. boydii brain abscesses are described. four of these patients acquired their infection after near-drowning; 1 patient developed an abscess after penetrating head trauma. two patients survived their infections, which included involvement of other body sites (lung, eye, bone) as well as multiple undrained brain abscesses, after prolonged courses of high-dose ...	1989	2739563
new spectrum of fungal infections in patients with cancer.	we report on 44 cancer patients who had serious infections with unusual fungal pathogens and who were cared for at our cancer center between 1974 and 1986. twelve different fungal species accounted for these infections, including trichosporon beigelii, fusarium species, geotrichum candidum, curvularia species, drechslera species, penicillium species (but not penicillium marneffei), rhodotorula rubra, pseudallescheria boydii, pichia farinosa, torulopsis pintolopesii, saccharomyces cerevisiae, and ...	1989	2749101
mycotic keratitis in madras.	corneal scrapings from 698 clinically suspected cases of mycotic keratitis were investigated for evidence of fungal infection. of these, 322 were found to be positive by direct examination and/or culture. the infection was predominantly seen in the age group 21-50. men were more frequently affected than women. majority of the patients were either agricultural workers or out door manual labourers and 66.8% of them gave a definite history of antecedent corneal trauma due to vegetable or soil matte ...	1989	2777350
pseudallescheria boydii keratomycosis in a horse.	the fungal organism pseudallescheria boydii was isolated from the cornea of a quarter horse with ulcerative keratitis. despite aggressive hourly medication through a subpalpebral lavage system, with drugs including miconazole and natamycin, the cornea developed a stromal abscess. orbital exenteration was performed after 3 weeks. the fungal isolate was later determined to be resistant to all 8 antifungal drugs tested. microscopic examination of the cornea revealed fungal hyphae throughout the cor ...	1989	2777709
organ-specific variation in the morphology of the fungomas (fungus balls) of pseudallescheria boydii. development within necrotic host tissue.	pseudallescheria boydii is an increasingly important cause of infection in debilitated and immunocompromised persons. it is frequently found within pulmonary cavities, where it forms matted collections of fungal hyphae, variously termed fungus balls, fungomas, or pseudallescheriomas. this report describes the unusual occurrence of pseudallescheriomas in the lungs, brain, and kidney. the morphological features of the fungomas varied between involved organs, with those in the lung showing well-def ...	1989	2712671
central nervous system infection caused by pseudallescheria boydii: case report and review.	pseudallescheria boydii is an uncommon cause of central nervous system (cns) infections. of a total of 21 cases of cns infections caused by p. boydii (one described for the first time and 20 reported previously in the english-language literature), eight occurred in immunosuppressed patients and four in patients who nearly drowned; three were trauma related and two were iatrogenic (epidural anesthesia and ventriculoperitoneal shunt, respectively); one occurred in a patient with insulin-dependent ...	1989	2690286
cerebral pseudallescheria boydii infection: unique occurrence of fungus ball formation in the brain.	pseudallescheria (petriellidium) boydii is the most frequent etiologic agent of mycetoma in temperate regions of the world. in addition, it may also occur as a systemic infection in immunocompromised patients. infection of the central nervous system is rare, and only eleven cases of pseudallescheria brain abscess have been documented. we report a leukemic patient in whom disseminated pseudallescheriasis was diagnosed only after death. this case is unique in that a white matter cavitation was pre ...	1989	2538287
superior sagittal sinus infection with petriellidium boydii: case report.	a case of infection of the superior sagittal sinus with petriellidium boydii is reported. this relatively common fungal pathogen rarely invades the central nervous system. immunological compromise and poor personal hygiene seem to be common attributes shared by this patient and the 4 previous patients reported to have suffered invasion of the central nervous system by this organism. this report is unique in that it is the first demonstrating apparent hematogenous dissemination of this organism t ...	1989	2710306
the first case of pseudallescheria boydii meningitis in china--electron microscopic study and antigenicity analysis of the agent.	reported in this paper is the first case of isolation of pseudallescheria boydii from cerebral spinal fluid of a boy with meningitis in china. morphology and culture were observed by light microscopy, electron scanning microscopy and transmission electron microscopy. in addition, mycelium antigen prepared by sds-page was compared with that of the other strain of scedosporium apiospermum. both of the strains showed more than 40 peptide lines. their molecular weight was very similar. on the cs-930 ...	1990	2098578
pseudallescheria boydii infection of the central nervous system.	pseudallescheria boydii is a rare cause of central nervous system infection characteristically presenting as a neutrophilic meningitis or multiple brain abscesses. factors predisposing to central nervous system infection with this fungus include immunosuppression and near drowning. the organism is infrequently cultured from fluid obtained by lumbar puncture, delaying clinical recognition and appropriate antifungal therapy. all untreated patients with p boydii infection of the central nervous sys ...	1990	2181980
in vitro activities of polyene and imidazole antifungal agents against unusual opportunistic fungal pathogens.	guidelines for the treatment of infections caused by unusual opportunistic fungi are limited and available in vitro data are scanty. in vitro susceptibility tests, employing an agar dilution procedure, were performed with amphotericin b (amb), natamycin (ntc), itraconazole (icz), and ketoconazole (ktz). two media were used: kimmig's agar (ka) and yeast morphology agar (yma). fungi tested included isolates (n) of acremonium spp. (10), cunninghamella spp. (6), fusarium spp. (18), pseudallescheria ...	1990	2233893
pseudallescheria boydii and brain abscesses.		1990	2235148
persistent neutrophilic meningitis due to pseudallescheria boydii.		1990	2237138
the epidemiology of pseudallescheriasis complicating transplantation: nosocomial and community-acquired infection.	the epidemiology of two cases of pseudallescheriasis in organ transplant patients are described and the disease in that population is reviewed. disseminated hospital-acquired infection occurred in a liver transplant recipient and was fatal despite therapy with miconazole. a heart transplant recipient developed localized disease following soil contamination of soft tissue trauma which was cured with surgical resection and miconazole therapy. itraconazole showed in vitro activity against pseudalle ...	1990	2259370
native valve endocarditis due to pseudallescheria boydii in a patient with aids: case report and review.	a 53-year-old man with aids developed mitral valve endocarditis due to infection with the fungus pseudallescheria boydii. a limited number of cases of prosthetic valve endocarditis caused by this organism have been described. we report a unique case of pseudallescheria infection of a native valve and describe this disease in a patient with aids.	1990	2267494
mixed allergic bronchopulmonary fungal disease due to pseudallescheria boydii and aspergillus.	a 24 year old asthmatic woman with mixed allergic bronchopulmonary fungal disease due to pseudallescheria boydii and aspergillus is reported. no previous cases due to p boydii have been described. this patient provides evidence that fungi other than aspergillus species may cause the condition.	1990	2392795
[fungus-induced arthritis caused by scedosporium apiospermum (pseudallescheria boydii)].	scedosporium (monosporium) apiospermum is the most common causative agent of maduro mycosis. recent research reports claim that this fungus can also induce arthritis. we report on the disease in a woman from a rural area who was admitted to our clinic because of arthritis symptoms. we were able to detect scedosporium apiospermum, i.e., it was probably a fungus-induced arthritis which had developed after an intraarticular steroid injection.	1991	1746172
pseudallescheria boydii keratitis.	pseudallescheria boydii is one of the rarer organisms known to cause mycotic keratitis, only 13 previous cases having been reported in the literature. what is believed to be the first case of pseudallescheria boydii keratitis successfully treated with topical miconazole is reported here.	1991	1776428
endogenous pseudallescheria boydii endophthalmitis. clinicopathologic findings in two cases.	two cases of endogenous pseudallescheria boydii endophthalmitis are presented. one patient had severe pulmonary fibrosis but no history of ocular trauma and no clinical or laboratory evidence of immunocompromise. despite therapy with repeated intravitreal miconazole nitrate injections and systemic fluconazole, enucleation of the globe was required, and the patient eventually died with disseminated pseudallescheriasis. the other patient was an immunosuppressed cardiac transplant recipient who als ...	1991	1841583
disseminated infection with pseudallescheria boydii in a patient with chronic granulomatous disease: response to gamma-interferon plus antifungal chemotherapy.		1991	1908570
the antigenic composition and protein profiles of eumycetoma agents.	the protein profiles of different eumycetoma agents were compared by sds gel electrophoresis. dendrograms confirmed the homogeneity of isolates of pseudallescheria boydii but amongst madurella species, particularly isolates identified as m. grisea, there were substantial differences in protein composition. however using western blotting reference isolates of the different species showed distinct antigen patterns in response to immune rabbit sera. in particular there was little evidence of cross ...	1991	1922185
fungal endophthalmitis. an experimental study with a review of 17 human ocular cases.	pseudallescheria boydii is an opportunistic fungus that is histologically indistinguishable from aspergillus fumigatus. pseudallescheria boydii has been reported to cause endophthalmitis, orbital cellulitis, and corneal ulceration and is, thus, important to the ophthalmologist. a clinical review of 17 patients with p boydii ophthalmic infections is presented. in addition, animal models of endophthalmitides caused by a fumigatus and p boydii were created and compared. dutch-belted rabbits used fo ...	1991	1929959
spectrophotometric method of inoculum preparation for the in vitro susceptibility testing of filamentous fungi.	homogeneous inoculum suspensions of 29 isolates of clinically important filamentous fungi were adjusted with a spectrophotometer (530 nm) to obtain standardized preparations containing 1 x 10(6) to 5 x 10(6) cfu/ml. colony counts (cfu per milliliter) of 1 x 10(6) to 5 x 10(6) were achieved on three different days for isolates of aspergillus spp., pseudallescheria boydii, and sporothrix schenckii (80% +/- 2% transmission), and colony counts of 7 x 10(5) to 2.9 x 10(6) (70% +/- 2% transmission) we ...	1991	2007647
surgical treatment for a case of postoperative pseudallescheria boydii endophthalmitis.	pseudallescheria boydii (p. boydii) is an uncommon ocular pathogen which previously has been identified in only 10 of 905 fungal isolates identified by the sid richardson microbiology laboratory at the cullen eye institute of baylor college of medicine. furthermore, only one case of postoperative p. boydii endophthalmitis and four cases of endogenous p. boydii endophthalmitis have been reported. three of the four patients with endogenous endophthalmitis died within 4 weeks of diagnosis. we descr ...	1991	2038484
[therapy of systemic mycoses in neutropenic patients using itraconazole. a comparative, randomized study with amphotericin b].	systemic mycosis constitute a serious threat for the patient with granulocytopenia. the most important causative agents are candida spp., aspergillus spp. and, to a lesser extent, cryptococcus neoformans, mucoraceae and pseudoallescheria boydii. treatment of such infections with amphotericin b is difficult, because of the many side-effects of this medicine, such as hypotension, fever, shivering, thrombophlebitis, nephrotoxicity, renal tubular acidosis, hypokalaemia, anaemia and thrombocytopenia. ...	1991	1663200
disseminated nocardia transvalensis infection: an unusual opportunistic pathogen in severely immunocompromised patients.	nocardia infections are infrequently recognized in humans. nocardia species may cause severe life-threatening infections among immunocompromised patients and have been reported to cause actinomycotic mycetomas, primarily in tropical areas. two severely immunocompromised patients had disseminated n. transvalensis infections. one had underlying x-linked variant chronic granulomatous disease and died of disseminated n. transvalensis infection, which was diagnosed only at postmortem examination. the ...	1992	1727888
treatment failure in a case of fungal keratitis caused by pseudallescheria boydii.	a case is presented of pseudallescheria boydii fungal keratitis in an agricultural welder. treatment with azole antifungal drugs (miconazole and itraconazole) and with penetrating keratoplasty was unsuccessful in eradicating the infection, and eventually the eye was eviscerated.	1992	1320401
fungal pseudoallescheria boydii lung infiltrates unresponsive to amphotericin b in leukaemic patients.	the management of patients with acute leukaemia is often complicated by serious fungal infections, especially of the lungs. the outcome of therapy has historically depended on the early use, efficacy and toxicity of amphotericin b. pseudoallescheria boydii is an uncommon cause of such infections but as it is more often resistant to amphotericin b early identification may enable the prompt use of alternative and newer antifungal agents. here we report our experience and review the literature in t ...	1992	1323256
effects of culture media on the in vitro susceptibility of selected opportunistic fungi to fluconazole and itraconazole.	the sensitivity of 23 isolates of opportunistic fungi, aspergillus fumigatus (5), a. flavus (5), a. niger (5), pseudallescheria boydii (5), alternaria alternata (2) and xylohypha bantiana (1), was investigated against fluconazole and itraconazole, using sabouraud's dextrose broth (sd) and a high-resolution (hr) medium (pfizer, inc.). the procedure followed was a standard tube dilution (1 ml/tube) method. candida albicans y01 09 was included as reference strain to monitor quality and reproducibil ...	1992	1324830
acute pyogenic pseudallescheria boydii foot infection sequentially treated with miconazole and itraconazole.		1992	1335468
convergence in ascospore discharge mechanism among pyrenomycete fungi based on 18s ribosomal rna gene sequence.	fungi of the class pyrenomycetes (ascomycotina) form a morphological series ranging from those that shoot ascospores (sexual spores) forcibly from the ascus (spore sac) to fungi that ooze ascospores or have no obvious mechanism for ascospore release. did forcible ascospore discharge evolve within these pyrenomycetes, or has it been lost in the group? we determined the sequences of the 18s ribosomal rna gene from three fungi and used these, along with six sequences from our previous work and thre ...	1992	1342925
immunohistologic diagnosis of systemic mycoses: an update.	fluorescent antibody, immunoperoxidase and gold-silver staining methods for the rapid and accurate diagnosis of systemic mycotic infections are currently performed in a few specialized laboratories. these methods have proved applicable to formalin-fixed, paraffin-embedded tissues, and are reliable for identifying therein antigens of infectious dimorphic, monomorphic filamentous, and yeast-like fungal pathogens, i.e., aspergillus spp., blastomyces dermatitidis, candida spp., coccidioides immitis, ...	1992	1397200
pseudallescheria boydii endocarditis of the pulmonic valve in a liver transplant recipient.	we describe a case of pseudallescheria boydii endocarditis involving the pulmonic valve in an orthotopic liver transplant recipient. the patient required transplantation because of hepatic failure secondary to chronic active hepatitis b. his postoperative course was complicated by surgery for gastric and duodenal ulcers, persistent fever, and, ultimately, sepsis leading to oliguric renal failure. two days before death, the patient experienced complete heart block, and an echocardiogram revealed ...	1992	1445984
pseudallescheria boydii keratitis.	we treated a case of post-traumatic keratitis caused by the soil saprophyte, pseudallescheria boydii. the injury was caused by a wood splinter which produced a perforating corneal laceration that was primarily repaired. signs of corneal infection were not evident until the fourth postoperative week. the organism was eradicated by topical miconazole and natamycin. subsequent penetrating keratoplasty combined with cataract extraction and intraocular lens implantation has achieved a good visual out ...	1992	1449780
cyclosporine interactions with miconazole and other azole-antimycotics: a case report and review of the literature.	several antimicrobial drugs have been shown to pharmacokinetically interact with cyclosporine. on two separate occasions, we observed increases in cyclosporine plasma concentrations during concomitant miconazole therapy in a heart transplant patient with an infection secondary to pseudallescheria boydii. to our knowledge, no interaction between cyclosporine and miconazole has previously been reported. in addition, drug interactions were observed between cyclosporine and ketoconazole and possibly ...	1992	1457436
mycotic keratitis: a study in coastal karnataka.	fungi were isolated from 67 cases out of the 295 cases of corneal ulcers investigated. aspergillus species and species of candida were the major fungal members isolated. allescheria boydii was isolated from 3 cases, having no previous history of injury to the eye or infection with bacterial or viral agents. a boydii corneal infection is a rare occurrence. higher incidence of mystic keratitis was seen among females than males. no relationship to seasonal changes could be established. bacterial in ...	1992	1464454
pulmonary mycetomas in immunocompetent patients: diagnosis by fine-needle aspiration.	mycetomas usually grow within preexisting cavities and frequently lead to pulmonary hemorrhage. we describe four males, aged 38 to 72 years, in whom myceotomas were diagnosed by fna. preexisting cavitary lesions resulted from tuberculosis, anaerobic abscess, and bullous lung disease (two cases). fine needle aspiration yielded tangled mats of fungal hyphae (large and grossly visible in three cases) and acute inflammatory cells. the atypical cells often seen in the walls of such lesions were not i ...	1992	1468333
approaches to management of fungal infections in cancer patients.	the patient most susceptible to invasive aspergillosis has had prolonged granulocytopenia resulting from intensive chemotherapy and/or radiation therapy, aplastic anemia, or acute leukemia. the sinuses and lungs are usually involved, but the infection may disseminate to the endocardium, skin, cns, and eye. efficacy of antifungal treatment with amphotericin b depends on early recognition and aggressive intervention. in severe or refractory cases, addition of flucytosine, rifampin, or fluconazole ...	1992	1534671
pseudallescheria boydii keratomycosis in a dog.	a dog that had a chronic history of keratoconjunctivitis sicca and was being treated topically with antibiotics and corticosteroids was examined for evaluation of a melting corneal ulcer. cytologic examination and cultures revealed the pathogen to be pseudallescheria boydii, a saprophytic fungus. the eye was surgically removed and evaluated histologically. fungal keratitis is rarely reported in dogs, but needs to be considered in refractory infections or in dogs treated with antibiotics or corti ...	1992	1559876
invasive sinusitis due to pseudallescheria boydii in an immunocompetent host.	chronic invasive sinusitis with pseudallescheria boydii as the etiologic agent is uncommon but occurs in immunocompetent hosts. we have presented the fourth documented case of sinusitis due to p boydii in a patient without other medical problems. pseudallescheria is generally sensitive to ketoconazole and not amphotericin b in therapeutic levels. in vitro culture and sensitivity studies are essential in selecting the appropriate antibiotic.	1992	1566153