Publications

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isolation and characterisation of beauveria bassiana isolates from phylloplanes of hedgerow vegetation.a leaf imprinting technique combined with a selective medium was used to document the natural occurrence of beauveria bassiana on phylloplanes of typical hedgerow plants (grasses, stinging nettle and hawthorn) in may, july and september in a hedgerow in denmark. the density of b. bassiana (as measured by numbers of colony forming units) was greatest in september and on lower nettle leaves. b. bassiana was isolated from phylloplanes in a different hedgerow the following year and a similar picture ...200616378721
spatial distribution of aglais urticae (l.) and its host plant urtica dioica (l.) in an agricultural landscape: implications for bt maize risk assessment and post-market monitoring.over the past decades, genes of bacillus thuringiensis var. kurstaki (berliner) (bt) coding for protein toxins have been engineered into maize for protection against the european corn borer (ostrinia nubilalis (hbn.)). however, these transgenic plants may have an impact on non-target organisms. in particular, a potential hazard was identified for non-target lepidopteran larvae, if they consume bt maize pollen on their host plants. risk can be defined as a function of the effect of an event (haza ...200616978572
allergenic proteins in urtica dioica, a member of the urticaceae allergenic family.allergy to the pollen of flowering plant species significantly affects the health of people in many parts of the world. pollens of related genera usually share common antigens and are often, but not always, cross-reactive. several studies have shown that parietaria pollen is one of the most common causes of pollinosis in the mediterranean area, whereas urtica has no allergenic significance.200617042140
carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (dc-sign)-directed hiv-1 transmission to t lymphocytes.exposure of hiv-1 to dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (dc-sign)-expressing b-lymphoblast raji cells (raji/dc-sign) but not to wild-type raji/0 cells results in the capture of hiv-1 particles to the cells as measured by the quantification of cell-associated p24 antigen. cocultivation of hiv-1-captured raji/dc-sign cells with uninfected cd4+ t lymphocyte c8166 cells results in abundant formation of syncytia within 36 h after cocultivation. short preexp ...200717056872
an ethnobotanical study on the usage of wild medicinal herbs from kopaonik mountain (central serbia).an ethnobotanical survey was carried out on the territory of the highest mountain in central serbia, kopaonik, which is characterized by great plant diversity. in total, 83 wild species from 41 families and 96 preparations for use in human therapy were recorded. among those wild plants which are most commonly used for medicinal purposes, hypericum perforatum l., urtica dioica l., achillea millefolium l., matricaria chamomilla l., sambucus nigra l., and thymus serpyllum l. were particularly highl ...200717145148
gynaecomastia in a man and hyperoestrogenism in a woman due to ingestion of nettle (urtica dioica).nettle (urtica dioica) is commonly sold as a herbal tea in turkey. we report a case of gynaecomastia in a man (in which the only aetiologic factor identified was nettle tea consumption) and a case of galactorrhoea in a woman (in which the only aetiologic factor identified was also nettle tea ingestion).200718264183
the protective activity of urtica dioica leaves on blood glucose concentration and beta-cells in streptozotocin-diabetic rats.this study was done to determine the protective activity of the hydroalcholic extract of urtica dioica leaves on hyperglycemia and beta-cells in hyperglycemic rats. thirty wistar rats were allocated in groups of normal, diabetic and treatment. hyperglycemia in rats induced by 80 mg kg(-1) streptozotocin. in treatment group, animals received hydroalcholic extract of urtica dioica 100 mg kg(-1) day(-1) for five days, intraperitoneally and then hyperglycemia induced by streptozotocin. the blood glu ...200719069917
effect of urtica dioica on morphometric indices of kidney in streptozotocin diabetic rats--a stereological study.the aim of the present study was to investigate the effect of urtica dioica on morphometric indices of kidney in diabetic rats. thirty male adult albino wistar rats of 125-175 g divided into control, diabetic and urtica dioica treatment groups. in treatment group, diabetic rats received 100 mg kg(-1) daily hydroalcoholic extract of u. dioica intraperitoneally for 4 weeks. after the animals had been sacrified, the kidneys were removed and fixed by formaldehyde, cut horizontally into 1 mm slices a ...200719090245
complementary and alternative medicine use in pediatric oncology patients in eastern turkey.the use of complementary and alternative medicines (cam) among children with cancer is becoming increasingly popular. therefore, it is important to gain insight into the prevalence and factors related to the use of cam. this study presents findings from a study of parents of 88 children with cancer who were receiving or had received conventional therapy for treatment of childhood cancer at a pediatric oncology unit in eastern turkey. the findings indicated that 48.9% of the respondents reported ...200717235218
medicinal plants used in kirklareli province (turkey).in this paper, 126 traditional medicinal plants from kirklareli province in turkey have been reported. one hundred and twenty six plant species belonging to 54 families and among them 100 species were wild and 26 species were cultivated plants. most used families were rosaceae, labiatae, compositae and the most used plants were cotinus coggyria, sambucus ebulus, achillea millefolium subsp. pannonica, hypericum perforatum, matricaria chamomilla var. recutita, melissa officinalis subsp. officinali ...200717257791
ethnoveterinary medicines used for ruminants in british columbia, canada.the use of medicinal plants is an option for livestock farmers who are not allowed to use allopathic drugs under certified organic programs or cannot afford to use allopathic drugs for minor health problems of livestock.200717324258
wild vascular plants gathered for consumption in the polish countryside: a review.this paper is an ethnobotanical review of wild edible plants gathered for consumption from the end of the 18th century to the present day, within the present borders of poland.200717433114
the importance of a taste. a comparative study on wild food plant consumption in twenty-one local communities in italy.a comparative food ethnobotanical study was carried out in twenty-one local communities in italy, fourteen of which were located in northern italy, one in central italy, one in sardinia, and four in southern italy. 549 informants were asked to name and describe food uses of wild botanicals they currently gather and consume. data showed that gathering, processing and consuming wild food plants are still important activities in all the selected areas. a few botanicals were quoted and cited in mult ...200717480214
antiviral activity of carbohydrate-binding agents against nidovirales in cell culture.coronaviruses are important human and animal pathogens, the relevance of which increased due to the emergence of new human coronaviruses like sars-cov, hku1 and nl63. together with toroviruses, arteriviruses, and roniviruses the coronaviruses belong to the order nidovirales. so far antivirals are hardly available to combat infections with viruses of this order. therefore, various antiviral strategies to counter nidoviral infections are under evaluation. lectins, which bind to n-linked oligosacch ...200717560666
elevation protective role of camellia sinensis and urtica dioica infusion against trichloroacetic acid-exposed in rats.this study was designed to investigate the protective effects of two traditionally used turkish medicinal plants, camellia sinensis (cs) and urtica dioica l. (ud), beverages used against chemical carcinogen trichloroacetic acid (tca)-exposure in rats. the preventive potential of the plant infusions was evaluated by measuring the level of serum marker enzymes, aspartate aminotransferase (ast), alanine aminotransferase (alt), creatine phosphokinase (cpk), acid phosphatase (acp), alkaline phosphata ...200717622976
the dispersal of vascular plants in a forest mosaic by a guild of mammalian herbivores.endozochorous seed dispersal by herbivores can affect plant spatial dynamics and macroecological patterns. we have investigated the number and species composition of viable seeds deposited in faeces of a full guild of macroherbivores (four deer and two lagomorph species) in a forest in eastern britain. one hundred and one plant species germinated from faecal pellet material, 85 of which were among the 247 vascular plant species recorded in the forest. however, three species - chenopodium album, ...200717661087
the carbohydrate-binding plant lectins and the non-peptidic antibiotic pradimicin a target the glycans of the coronavirus envelope glycoproteins.many enveloped viruses carry carbohydrate-containing proteins on their surface. these glycoproteins are key to the infection process as they are mediators of the receptor binding and membrane fusion of the virion with the host cell. therefore, they are attractive therapeutic targets for the development of novel antiviral therapies. recently, carbohydrate-binding agents (cba) were shown to possess antiviral activity towards coronaviruses. the current study further elucidates the inhibitory mode o ...200717704516
complementary/alternative medicine use in a pediatric oncology unit in turkey.important in the cancer therapy is the increasingly use of complementary/alternative medicine (cam). the current study aims to establish the extent of use, the types of therapies employed, factors influencing, the reasons for choosing and the cost of cam used in pediatric cancer patients in our clinic in ankara, turkey.200716900485
antioxidant capacity changes and phenolic profile of echinacea purpurea, nettle (urtica dioica l.), and dandelion (taraxacum officinale) after application of polyamine and phenolic biosynthesis regulators.the changes of the antioxidant (aoa) and antiradical activities (ara) and the total contents of phenolics, anthocyanins, flavonols, and hydroxybenzoic acid in roots and different aerial sections of echinacea purpurea, nettle, and dandelion, after treatment with ornithine decarboxylase inhibitor, a polyamine inhibitor (o-phosphoethanolamine, kf), and a phenol biosynthesis stimulator (carboxymethyl chitin glucan, cchg) were analyzed spectrophotometrically; hydroxycinnamic acids content was analyze ...200717579437
combined hplc-cuprac (cupric ion reducing antioxidant capacity) assay of parsley, celery leaves, and nettle.this study aims to identify the essential antioxidant compounds present in parsley (petroselinum sativum) and celery (apium graveolens) leaves belonging to the umbelliferae (apiaceae) family, and in stinging nettle (urtica dioica) belonging to urticaceae family, to measure the total antioxidant capacity (tac) of these compounds with cuprac (cupric ion reducing antioxidant capacity) and abts spectrophotometric methods, and to correlate the tac with high performance liquid chromatography (hplc) fi ...200818804638
trends in prevalence of allergic rhinitis and correlation with pollen counts in switzerland.in recent decades, a large number of epidemiological studies investigating the change of prevalence of hay fever showed an increase in the occurrence of this disease. however, other studies carried out in the 1990s yielded contradictory results. many environmental factors have been hypothesized to contribute to the increasing hay fever rate, including both indoor and ambient air pollution, reduced exposure to microbial stimulation and changes in diets. however, the observed increase has not conv ...200818751737
risks and benefits of commonly used herbal medicines in mexico.in mexico, local empirical knowledge about medicinal properties of plants is the basis for their use as home remedies. it is generally accepted by many people in mexico and elsewhere in the world that beneficial medicinal effects can be obtained by ingesting plant products. in this review, we focus on the potential pharmacologic bases for herbal plant efficacy, but we also raise concerns about the safety of these agents, which have not been fully assessed. although numerous randomized clinical t ...200818037151
in vitro nematicidal effects of medicinal plants from the sierra de huautla, biosphere reserve, morelos, mexico against haemonchus contortus infective larvae.twenty extracts from plants from sierra de huautla biosphere reserve, morelos, mexico were evaluated against haemonchus contortus infective larvae in an in vitro assay. the plant species evaluated were bursera copallifera, b. grandifolia, lippia graveolens, passiflora mexicana, prosopis laevigata, randia echinocarpa and urtica dioica. the plants were separated into their parts and macerated with different solvents (n-hexane, acetone, ethanol and methanol). an in vitro assay was used to evaluate ...200818053304
biological screening of some turkish medicinal plant extracts for antimicrobial and toxicity activities.screening of antibacterial activity and toxicity of 22 aqueous plant extracts from 17 turkish plants was conducted. antibacterial activity was performed with six bacteria including escherichia coli, pseudomonas aeruginosa, klebsiella pneumoniae, streptococcus pyogenes, staphylococcus aureus and staphylococcus epidermidis. extracts of tussilago farfara leaves, helichyrsum plicatum flowers, solanum dulcamara aerial parts and urtica dioica leaves gave the best inhibitory activity against s. pyogene ...200818075897
factors related to complementary/alternative medicine use among cancer patients in central anatolia.we aimed to evaluate the prevalence of and factors related to the use of complementary/alternative medicine among cancer patients undergoing or following conventional treatment at the erciyes university oncology hospital in central anatolia.200819267101
safety concerns for the potential use of cyanovirin-n as a microbicidal anti-hiv agent.based on its antiviral activity profile, cyanovirin-n (cv-n) holds great potential for anti-hiv microbicidal application. however, limited data are available on the possible side-effects of this lectin. a detailed investigation was carried out to obtain better insights in the cytotoxic, inflammatory and (anti)-proliferative properties of cv-n in comparison with several other plant-derived lectins. cv-n affected the cell morphology of pbmcs and enhanced the expression of the cellular activation m ...200818598778
toxicological assessment of p-9801091 plant mixture extract after chronic administration in cba/hzg mice--a biochemical and histological study.acute, subchronic and chronic effects of the p-9801091 plant mixture extract at a dose of 20 mg/kg body mass were assessed in serum of healthy cba/hzg mice at 24 hours, 7 days, 3 months and 6 months of treatment (experimental group), and compared with the values obtained in the control group of untreated healthy cba/hzg mice. the p-9801091 plant mixture extract is an antihyperglycemic preparation containing myrtilli folium (vaccinium myrtillus l.), taraxaci radix (taraxacum officinale web.), cic ...200818756913
the granule cell density of the dentate gyrus following administration of urtica dioica extract to young diabetic rats.urtica dioica l. stinging nettle has long been known worldwide as a medicinal plant. to study the benefits of the nettle in diabetic encephalopathy, the granule cell density of the dentate gyrus of diabetic rats was studied following administration of urtica dioica extract. a total of 24 male albino wistar rats were allocated equally to normal, diabetic, preventive and treatment groups. hyperglycaemia was induced by streptozotocin (80 mg/kg) in the animals of the diabetic and treatment groups. o ...200818828102
glycan deletions in the hiv-1 gp120 v1/v2 domain compromise viral infectivity, sensitize the mutant virus strains to carbohydrate-binding agents and represent a specific target for therapeutic intervention.carbohydrate-binding agents (cbas), such as the mannose-specific hippeastrum hybrid agglutinin (hha) and the glcnac-specific urtica dioica agglutinin (uda), frequently select for glycan deletions in all different domains of hiv-1 gp120, except in the v1/v2 domain. to reveal the underlying mechanisms, a broad variety of 31 different virus strains containing one or several n-glycan deletions in v1/v2 of the gp120 of the x4-tropic hiv-1(nl4.3) were constructed by chimeric virus technology. no co-re ...200818930512
maintaining a physiological blood glucose level with 'glucolevel', a combination of four anti-diabetes plants used in the traditional arab herbal medicine.safety and anti-diabetic effects of glucolevel, a mixture of dry extract of leaves of the juglans regia l, olea europea l, urtica dioica l and atriplex halimus l were evaluated using in vivo and in vitro test systems. no sign of toxic effects (using ldh assay) were seen in cultured human fibroblasts treated with increasing concentrations of glucolevel. similar observations were seen in vivo studies using rats (ld50: 25 g/kg). anti-diabetic effects were evidenced by the augmentation of glucose up ...200818955212
the use of complementary therapies in cancer patients: a questionnaire-based descriptive survey from southeastern turkey.a study was designed to measure the frequency of complementary therapy (ct) usage in cancer patients in southeastern turkey. the demographic characteristics associated with the use of ct are sought in patients undergoing or following conventional treatment.200819060593
an experimental study of nettle feeding in captive gorillas.mountain gorillas (gorilla beringei beringei) in karisoke, rwanda, feed on the stinging nettle laportea alatipes by means of elaborate processing skills. byrne [e.g. philosophical transactions of the royal society of london, series b, biological sciences 358:529-536, 2003] has claimed that individuals acquire these skills by means of the so-called program-level imitation, in which the overall sequence of problem-solving steps (not the precise actions) is reproduced. in this study we present west ...200818330896
clinical and histopathological evaluation of mdp/collagen induced arthritis rat model (mcia) after treatment with urtica dioica, plantago major and hypericum perforatum l herbal mixture.this study was done to assess the effects of urtica dioica, plantago major and hypericum perforatum l herbal mixture in the mcia rat model. in addition, a new pathological and clinical arthritis lesion assessment was developed. sprague-dawley (sd) rats were immunized with bovine type ii collagen and muramyl dipeptide (mdp). commercial herbal extracts were administered daily to the rats after the immunization for the course of experiment (90 days). rats were boosted with a second collagen-mdp emu ...200818421172
simian immunodeficiency virus is susceptible to inhibition by carbohydrate-binding agents in a manner similar to that of hiv: implications for further preclinical drug development.carbohydrate-binding agents (cbas), such as the plant lectins hippeastrum hybrid agglutinin (hha) and urtica dioica agglutinin (uda), but also the nonpeptidic antibiotic pradimicin a (prm-a), inhibit entry of hiv into its target cells by binding to the glycans of gp120. given the high sequence identity and similarity between the envelope gp120 glycoproteins of hiv and simian immunodeficiency virus (siv), the inhibitory activity of a variety of cbas were evaluated against hiv-1, hiv-2, and siv. t ...200818474667
inhibition of cell-to-cell transmission of human t-cell lymphotropic virus type 1 in vitro by carbohydrate-binding agents.peripheral blood mononuclear cells (pbmcs) from healthy individuals can be infected by human t-lymphotropic virus type 1 (htlv-1) upon cocultivation of the pbmcs with irradiated htlv-1-transformed human mt-2 cells. this model system closely mimics htlv-1 transmission through cell-to-cell contact. carbohydrate-binding agents (cbas) such as the alpha(1,3)/alpha(1,6)mannose-specific hippeastrum hybrid agglutinin and the glcnac-specific urtica dioica agglutinin, and also the small, nonpeptidic alpha ...200818505856
an investigation on the anticandidal activity of some traditional medicinal plants in turkey.methanol and chloroform extracts obtained from eight plant species belonging to six families, which were selected depending on their use in turkish folk medicine, including mentha longifolia l. (labiatae), mentha piperita l. hudson (labiatae), prongos ferulaceae (umbelliferae), galium verum l. (rubiaceae), salvia limbata c. a meyer (labiatae), artemisia austriaca jacq. (artemiceae), plantago lanceolata l. (plantaginaceae) and urtica dioica l. (urticaceae) were evaluated for their in vitro antica ...200918522697
the beneficial effects of nettle supplementation and exercise on brain lesion and memory in rat.regular swimming and phytotherapeutic supplementation are assumed to alleviate the severity of neurodegeneration leading to dementia. the effect of swimming training and that of enriched lab chow containing 1% (w/w) dried nettle (urtica dioica) leaf on the prevention of severity of brain injury caused by n-methyl-d-aspartate (nmda) lesion in wistar rats were investigated. nettle supplementation and regular swimming exercise seem to improve the adverse effect of brain injury caused by nmda lesion ...200919071007
effects of urtica dioica l. seed on lipid peroxidation, antioxidants and liver pathology in aflatoxin-induced tissue injury in rats.this study was carried out to investigate the hepatoprotective and antioxidant properties of urtica dioica l. seeds (uds) extract against aflatoxin (af)-exposure in rats. the preventive potential and antioxidant capacity of the plant's extract was evaluated by liver histopathological changes, measuring serum marker enzymes, antioxidant defense systems and lipid peroxidation (malondialdehyde, mda) content in some tissues of rats. eighteen rats were randomly divided into one of three experimental ...200919073231
complementary alternative medicine use in children with type 1 diabetes mellitus in erzurum, turkey.the aims of this study were: (i) to determine the types of complementary and alternative medicine use among children with type i diabetes mellitus as reported by parents and (ii) to describe sociodemographic and medical factors associated with the use of such treatments in families residing in eastern turkey.200919077023
effects of urtica dioica extract on lipid profile in hypercholesterolemic rats.to investigate the effects of extract of urtica dioica, a perennial herb in iran, on lipid profile in hypercholesterolemic rats.200919435556
the effect of urtica dioica extract on the number of astrocytes in the dentate gyrus of diabetic rats.diabetes mellitus is associated with cerebral alterations in both human and animal models of the disease. these alterations include abnormal expression of hypothalamic neuropeptides and hippocampal astrogliosis. urtica dioica (nettle) is among several species listed for their use against diabetes in folk medicine. the aim of this study was the evaluation of the astrocyte number in the dentate gyrus of diabetic rats after treatment with nettle. a total of 21 male albino wistar rats were used in t ...200919449296
characterization of bois noir isolates by restriction fragment length polymorphism of a stolbur-specific putative membrane protein gene.bois noir phytoplasma (bnp), widespread in wine-producing areas of europe and endemic in france and italy, is classified in the 16srxii-a subgroup, whose members are referred to as stolbur phytoplasmas. the 16s rdna gene of stolbur phytoplasma shows low variability, and few non-ribosomal genes are available as markers to assess variation among isolates. we used the stolbur-specific stol-1h10 gene, encoding a putative membrane-exposed protein, to investigate genetic diversity of french and italia ...200919453230
antifungal activity of nettle (urtica dioica l.), colocynth (citrullus colocynthis l. schrad), oleander (nerium oleander l.) and konar (ziziphus spina-christi l.) extracts on plants pathogenic fungi.anti-mycotic activity of the ethanol extracts from nettle (urtica dioica l.), colocynth (citrullus colocynthis l. schrad), konar (ziziphus spina-christi l.) and oleander (nerium oleander l.) floral parts were screened in vitro against four important plant pathogenic fungi viz.; alternaria alternate, fusarium oxysporum, fusarium solani and rizoctonia solani using agar dilution bioassay. extracts showed antifungal activity against all the tested fungi. among the plants, nettle and colocynth were t ...200919579919
the effects of urtica dioica l. leaf extract on aniline 4-hydroxylase in mice.the effects of hydroalcoholic (80% ethanol-20% water) extract of urtica dioica l. on microsomal aniline 4-hydroxylase (a4h) were investigated in the liver of swiss albino mice (8- 10-weeks-old) treated with two doses (50 and 100 mg/kg body weight, given orally for 14 days ). the activities of a4h showed a significant increase in the liver at both dose levels of extract treatment. the hydroalcoholic extract of urtica dioica induced the activities of a4h that had been increased by treatment of met ...200919645331
complementary-alternative medicine among cancer patients in the western region of turkey.to investigate the complementary/alternative medicine (cam) applications and factors affecting its use among cancer patients in the western region of turkey.200919650177
the efficacy of ankaferd blood stopper in antithrombotic drug-induced primary and secondary hemostatic abnormalities of a rat-bleeding model.ankaferd comprises a standardized mixture of plants thymus vulgaris, glycyrrhiza glabra, vitis vinifera, alpinia officinarum and urtica dioica. ankaferd blood stopper (abs) as a medicinal product has been approved in the management of external hemorrhage and dental surgery bleedings in turkey. this study aimed to evaluate the in-vivo hemostatic effect of abs in rats pretreated with acetylsalicylic acid or enoxaparin. wistar rats (210-270 g) of both sexes were used in this study. the animals were ...200919657315
a new mouse-adapted strain of sars-cov as a lethal model for evaluating antiviral agents in vitro and in vivo.severe acute respiratory syndrome (sars) is a highly lethal emerging disease caused by coronavirus sars-cov. new lethal animal models for sars were needed to facilitate antiviral research. we adapted and characterized a new strain of sars-cov (strain v2163) that was highly lethal in 5- to 6-week-old balb/c mice. it had nine mutations affecting 10 amino acid residues. strain v2163 increased il-1alpha, il-6, mip-1alpha, mcp-1, and rantes in mice, and high il-6 expression correlated with mortality. ...200919853271
in vivo hemostatic effect of the medicinal plant extract ankaferd blood stopper in rats pretreated with warfarin.ankaferd comprises a mixture of thymus vulgaris, glycyrrhiza glabra, vitis vinifera, alpinia officinarum and urtica dioica. ankaferd blood stopper (abs) has been approved in the management of bleedings. this study aimed to evaluate in vivo hemostatic effect of abs in rats pretreated with warfarin.200919117967
complementary and alternative medicine in cancer patients - analysis of influencing factors in turkey.this cross-sectional and descriptive study analysed complementary and alternative medicine (cam) practices of patients with cancer diagnoses and influencing factors.200920192589
[experience in treating digestive organ diseases with medicinal plants].results are reported of treatment of chronic hyposecretory gastritis, chronic hepatocholecystitis and angiocholitis by a herbal complex. the herbal composition included achillea millefolium, urtica dioica, cichorium (aboveground part), polygonum, matricaria chamomilla (flowers), helichrysum arenarium, calendula (flowers), corn stigmas, humulus lupulus (racemes) in proportion 3:3:1:1:2:1:1:2:1 respectively. the herbal decoction is to be taken 3 times daily before meals. diet n 5 (pevzner scheme) ...20092750130
regulation of inflammatory gene expression in pbmcs by immunostimulatory botanicals.many hundreds of botanicals are used in complementary and alternative medicine for therapeutic use as antimicrobials and immune stimulators. while there exists many centuries of anecdotal evidence and few clinical studies on the activity and efficacy of these botanicals, limited scientific evidence exists on the ability of these botanicals to modulate the immune and inflammatory responses. using botanogenomics (or herbogenomics), this study provides novel insight into inflammatory genes which ar ...201020838436
content of toxic and essential metals in medicinal herbs growing in polluted and unpolluted areas of macedonia.the aim of this study was to determine and compare ba, cr, cd, fe, sr, pb, and zn content in medicinal herbs urtica dioica l., taraxacum officinale, and matricaria recutita growing in polluted and unpolluted areas of the republic of macedonia. the metal content was determined using inductively coupled plasma atomic emission spectroscopy (icp-aes). in the unpolluted area of mt. plackovica the metal content in taraxacum officinale was in the descending order: fe>sr>zn>ba>cr, while pb and cd were b ...201020860970
[associating serenoa repens, urtica dioica and pinus pinaster. safety and efficacy in the treatment of lower urinary tract symptoms. prospective study on 320 patients].serenoa repens (saw palmetto) has been employed for the treatment of lower urinary tract symptoms (luts) for several years. its mechanism of action is believed to be due to antiandrogenic, antiproliferative and antinflammatory properties. an association of serenoa with the nettle "urtica dioica" showing antiproliferative activity and the pine "pinus pinaster" derivative, showing antinflammatory action, has been proposed in recent years. such an action is hoped to act not only by reducing luts bu ...201020890858
protective role of urtica dioica l. (urticaceae) extract on hepatocytes morphometric changes in stz diabetic wistar rats.the present investigation was carried out to evaluate the protective effect of the hydroalcoholic extract of urtica dioica leaves on the quantitative morphometric changes in the liver of streptozotocin-induced diabetic rats.201020931430
effect of bt-176 maize pollen on first instar larvae of the peacock butterfly (inachis io) (lepidoptera; nymphalidae).more than 10 years after registration of the first bt maize cultivar in europe, there still exists a remarkable lack of data on effects on lepidoptera which would be necessary for a complete and comprehensive environmental risk assessment. so far only very few european butterfly species have been tested in this aspect. in our study the effect of transgenic bacillus thuringiensis (bt) maize pollen (event bt-176) on the development and survival of neonate larvae of the peacock butterfly, inachis i ...201021122482
evaluation of hemostatic effects of ankaferd as an alternative medicine.ankaferd blood stopper (abs), a unique traditional herbal mixture, has been used topically to stop bleeding for centuries in anatolia. abs is a standardized mixture of the plants thymus vulgaris, glycyrrhiza glabra, vitis vinifera, alpinia officinarum, and urtica dioica. through its effects on the endothelium, blood cells, angiogenesis, cellular proliferation, vascular dynamics, and cell mediators, abs is now becoming an official alternative hemostatic medicine for intractable bleedings that are ...201021194248
effects of urtica dioica on hepatic ischemia-reperfusion injury in rats.to evaluate the effects of urtica dioica on hepatic ischemia-reperfusion injury.201021340227
the determination and fidelity level of medicinal plants used to make traditional turkish salves.this study has been done in order to identify plants that were used to make traditional turkish salves between 2007 and 2008.201020192916
a thermostable lectin from the rhizomes of kaempferia parviflora.kaempferia parviflora, or black galingale (kra-chai-dam), belongs to the zingiberaceae family and is used as both a food ingredient and a medicinal plant. there are diverse reports on the biological activities of compounds extracted from the plant, such as antimalarial, antifungal and an effective sexual-enhancing role, but not on the lectins.201020549650
effects of water extract of urtica dioica l. and modified atmosphere packaging on the shelf life of ground beef.effects of lyophilized urtica dioica l. water extract (luwe) and modified atmosphere packaging (map) on the quality and shelf life of ground beef were investigated. ground beef was stored as aerobic control, map (80%o(2)+20% co(2)), map+250 ppm luwe and map and 500 ppm luwe at 2+/-0.5 degrees c for 14 days. map and luwe had significant effects on mesophilic, psychrotrophic and lactic acid bacteria and pseudomonas counts. depending on the level of luwe, pseudomonas and psychrotrophic counts decre ...201020573457
a rat model of urtica ferox neuropathy.a species of stinging nettle, urtica ferox, is indigenous to new zealand and has caused deaths in animals and humans. we previously reported a human case of acute polyneuropathy due to u. ferox stings. we developed an experimental animal model of u. ferox toxin neuropathy to determine its neurophysiological and pathological characteristics. male wistar rats received either normal saline or fluid from u. ferox trichomes by injection into the epineurium of the left sciatic nerve. neurophysiologica ...201020650289
an ethnobotanical survey of medicinal plants in sivrice (elazığ-turkey).this study aimed to identify wild plants collected for medical purposes by the local people of sivrice county, located in the eastern anatolia region of turkey, and to establish the uses and local names of these plants.201020713142
antimicrobial effect of garlic (allium sativum).medicinal plants like pumpkin seed, thyme, onion, nigella sativa, lemon balm, and stinging nettle are used extensively today. one of these plants used most intensively and widespread is garlic. in this context, fresh shape, powder state and oil of garlic have been used all around the world, especially in far east for centuries. it is scientifically proven that garlic is effectively used in cardiovascular diseases as a regulator of blood pressure, with dropper effects on glycaemia and high blood ...201019929845
insulin mimetics in urtica dioica: structural and computational analyses of urtica dioica extracts.urtica dioica (ud) is a plant shown to reduce blood glucose levels upon oral ingestion; however, neither its active component nor its mechanism of action has been identified. one active fraction of this extract, termed ud-1, was separated by molecular sieve column chromatography and purified by high performance liquid chromatography (hplc). while ud-1 did not stimulate insulin secretion in glucose-responsive min6 clonal beta-cells, chronic exposure (24 h) significantly enhanced glucose uptake (a ...201020013820
use of lupin, lupinus perennis, mango, mangifera indica, and stinging nettle, urtica dioica, as feed additives to prevent aeromonas hydrophila infection in rainbow trout, oncorhynchus mykiss (walbaum).feeding rainbow trout, oncorhynchus mykiss (walbaum), with 1% lupin, lupinus perennis, mango, mangifera indica, or stinging nettle, urtica dioica, for 14 days led to reductions in mortality after challenge with aeromonas hydrophila. in addition, there was significant enhancement in serum bactericidal activity, respiratory burst and lysozyme activity in the treatment groups compared to the controls. use of lupin and mango led to the highest number of red blood and white blood cells in recipient f ...201020102439
antidiabetic effect of some medicinal plants of oriental morocco in neonatal non-insulin-dependent diabetes mellitus rats.the goal of the present study is to test the effect of water extract (we) of four medicinal plants used as antidiabetics in eastern morocco (arbutus unedo: au, ammoïdes pusilla: ap, thymelaea hirsuta: th, and urtica dioïca: ud). these plants are used in cooking to bring out the flavor in a dish or to complement it. the first experiment was realized in order to determine the antidiabetic effect of the we of these plants during 5 weeks' treatment. seven groups of wistar rats were used: healthy con ...201020154101
phenolic composition and antioxidant properties of some traditionally used medicinal plants affected by the extraction time and hydrolysis.polyphenolic phytochemicals in traditionally used medicinal plants act as powerful antioxidants, which aroused an increasing interest in their application in functional food development.201120848396
plants growing on contaminated and brownfield sites appropriate for use in organisation for economic co-operation and development terrestrial plant growth test.the organisation for economic co-operation and development (oecd) terrestrial plant test is often used for the ecological risk assessment of contaminated land. however, its origins in plant protection product testing mean that the species recommended in the oecd guidelines are unlikely to occur on contaminated land. six alternative species were tested on contaminated soils from a former zn smelter and a metal fragmentizer with elevated concentrations of cd, cu, pb, and zn. the response of the al ...201120853450
upper gastrointestinal bleeding in a patient with defective hemostasis successfully treated with ankaferd blood stopper.acute gastrointestinal (gi) bleeding is one of the most frequent causes for hospitalization and responsible for a major cause of morbidity and mortality among patients. ankaferd blood stopper (abs) is a herbal extract attained from five different plants thymus vulgaris, glycyrrhiza glabra, vitis vinifera, alpinia officinarum and urtica dioica. here we report a challenging upper gi bleeding case with a low platelet count and defective hemostasis treated endoscopically with abs as an adjunctive dr ...201120677211
pharmaceutical ethnobotany in the riverside of navarra (iberian peninsula).this paper provides significant ethnobotanical information on pharmaceutical plant uses in the riverside of navarra. thereby, it will extend and complement a recent previous study carried out in the northern navarra. this paper aim to collect, analyse and evaluate the ethnobotanical knowledge about medicinal plants in the riverside of navarra (iberian peninsula) with 2554.4km(2) and 144,674 inhabitants.201121345364
mechanism of action of stinging nettles.inadvertent exposure to the ubiquitous weed, urtica dioica, called "stinging nettles" produces an immediate stinging and burning sensation on the skin. this investigation evaluates the structural effect that stinging nettle spicules may have on the clinical manifestation of these symptoms. this hypothesis was investigated by exposing murine skin to stinging nettles and then evaluating the skin using electron microscopy. it was hypothesized that the mechanism of action of stinging nettles is both ...201121396858
suppression of growth and invasive behavior of human prostate cancer cells by prostacaid™: mechanism of activity.since the use of dietary supplements as alternative treatments or adjuvant therapies in cancer treatment is growing, a scientific verification of their biological activity and the detailed mechanisms of their action are necessary for the acceptance of dietary supplements in conventional cancer treatments. in the present study we have evaluated the anti-cancer effects of dietary supplement prostacaid™ (pc) which contains mycelium from medicinal mushrooms (ganoderma lucidum, coriolus versicolor, p ...201121468543
was the famous astronomer copernicus also a nephrologist.nicolaus copernicus (1473-1543), world-famous astronomer, born in toruń, was also a warmian canon (senior priest) and a physician to 4 consecutive prince-bishops of warmia and of other warmian canons. what medical conditions preoccupied nicolaus copernicus and whether they included kidney diseases can only be inferred from the extant prescriptions of copernicus, as no record remains of any treatises by copernicus regarding medicine. while no prescription penned by him is dated, several are trace ...201121614777
ameliorative effects of stinging nettle (urtica dioica) on testosterone-induced prostatic hyperplasia in rats.the present study investigated the effects of stinging nettle (urtica dioica l.) (ud) on benign prostatic hyperplasia (bph) induced by testosterone. in vitro studies were conducted to assess the 5a-reductase inhibitory potential of ud. two biochemical markers viz., ß-sitosterol and scopoletin, were isolated and characterised in the extracts utilising high-performance thin layer chromatographic, ftir, nmr and overlain uv spectral studies. hyperplasia was induced in rats by subcutaneous administra ...201121806658
organic parasite control for poultry and rabbits in british columbia, canada.abstract: plants used for treating endo- and ectoparasites of rabbits and poultry in british columbia included arctium lappa (burdock), artemisia sp. (wormwood), chenopodium album (lambsquarters) and c. ambrosioides (epazote), cirsium arvense (canada thistle), juniperus spp. (juniper), mentha piperita (peppermint), nicotiana sp. (tobacco), papaver somniferum (opium poppy), rubus spp. (blackberry and raspberry relatives), symphytum officinale (comfrey), taraxacum officinale (common dandelion), th ...201121756341
ethnopharmacological survey of medicinal plants in maden (elazig-turkey).this study aimed to identify wild plants collected for medical purposes by the local people of maden county, located in the eastern anatolia region of turkey, and to establish the uses and local names of these plants.201121704144
broad antiviral activity of carbohydrate-binding agents against the four serotypes of dengue virus in monocyte-derived dendritic cells.dendritic cells (dc), present in the skin, are the first target cells of dengue virus (denv). dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (dc-sign) is present on dc and recognizes n-glycosylation sites on the e-glycoprotein of denv. thus, the dc-sign/e-glycoprotein interaction can be considered as an important target for inhibitors of viral replication. we evaluated various carbohydrate-binding agents (cbas) against all four described serotypes of denv replica ...201121738755
in vitro antimicrobial activity of romanian medicinal plants hydroalcoholic extracts on planktonic and adhered cells.the aim of this study was to assess the antibacterial and antifungal potential of some romanian medicinal plants, arnica--arnica montana, wormwood--artemisia absinthium and nettle--urtica dioica. in order to perform this antimicrobial screening, we obtained the vegetal extracts and we tested them on a series of gram-positive and gram-negative bacteria, and also against two fungal strains. the vegetal extracts showed antimicrobial activity preferentially directed against the planktonic fungal and ...201121717806
The Effect of Stinging Nettle (Urtica dioica) Seed Oil on Experimental Colitis in Rats.Abstract This study investigated the effect of Urtica dioica, known as stinging nettle, seed oil (UDO) treatment on colonic tissue and blood parameters of trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. Experimental colitis was induced with 1?mL of TNBS in 40% ethanol by intracolonic administration with a 8-cm-long cannula with rats under ether anesthesia, assigned to a colitis group and a colitis+UDO group. Rats in the control group were given saline at the same volume by intrac ...201121861725
ankaferd hemostat in the management of gastrointestinal hemorrhages.gastrointestinal (gi) bleeding refers to any hemorrhage ascribed to the pathologies of the gastrointestinal tract, extending from the mouth to the anal canal. despite the recent improvements in the endoscopic, hemostatic and adjuvant pharmacologic techniques, the reported mortality is still around 5%-10% for peptic ulcer bleeding and about 15%-20% for variceal hemorrhages. although endoscopic management reduces the rates of re-bleeding, surgery, and mortality in active bleeding; early recurrence ...201122046083
ameliorative influence of urtica dioica l against cisplatin-induced toxicity in mice bearing ehrlich ascites carcinoma.abstract cisplatin (cp) is a widely used cytotoxic agent against cancer, and high doses of cp have been known to cause nephrotoxicity and hepatotoxicity. some reports claim that antioxidants can reduce cp-induced toxicity. this study investigated the hepatoprotective, nephroprotective, and antioxidant activity of urtica dioica l methanolic extract (udme) against cp toxicity in erhlich ascites tumor (eat)-bearing mice. levels of serum hepatic enzymes, renal function markers, and oxidant/antioxida ...201121939360
effects of drugs of plant origin on the development of the immune response.the effects of extracts from licorice (glycyrrhisa glabra), great nettle (urtica dioica), common burdock (arctium lappa), and bur marigold (bidens tripartite) on the humoral and cellular immune response and nonspecific resistance in mice were studied. burdock and bur marigold extracts stimulated the humoral immune response, nettle and licorice extracts stimulated cellular response and nonspecific resistance, their effects being superior to those of pharmacopoeial echinacea purpurea tincture.201122238748
survey of microfungi in the landschaftspark duisburg-nord (germany).during an excursion in the landschaftspark duisburg-nord in 2009 and 2010 we were able to collect and identify more than 100 specimens of microfungi on different parts of cultivated and wild plant species. we found parasitic and saprophytic microfungi on trees, bushes and herbaceous plants. some of them have been observed only rarely until now. most of the collected microfungi species belong to the classes of ascomycetes, basidiomycetes and deuteromycetes - for example leptosphaeria modesta (des ...201122702187
inhibition of severe acute respiratory syndrome coronavirus replication in a lethal sars-cov balb/c mouse model by stinging nettle lectin, urtica dioica agglutinin.urtica dioica agglutinin (uda) is a small plant monomeric lectin, 8.7 kda in size, with an n-acetylglucosamine specificity that inhibits viruses from nidovirales in vitro. in the current study, we first examined the efficacy of uda on the replication of different sars-cov strains in vero 76 cells. uda inhibited virus replication in a dose-dependent manner and reduced virus yields of the urbani strain by 90% at 1.1 ± 0.4 µg/ml in vero 76 cells. then, uda was tested for efficacy in a lethal sars-c ...201121338626
a new method for in situ measurement of bt-maize pollen deposition on host-plant leaves.maize is wind pollinated and produces huge amounts of pollen. in consequence, the cry toxins expressed in the pollen of bt maize will be dispersed by wind in the surrounding vegetation leading to exposure of non-target organisms (nto). nto like lepidopteran larvae may be affected by the uptake of bt-pollen deposited on their host plants. although some information is available to estimate pollen deposition on host plants, recorded data are based on indirect measurements such as shaking or washing ...201126467496
identification and phenology of hyalesthes obsoletus (hemiptera: auchenorrhyncha: cixiidae) nymphal instars.urtica dioica and convolvulus arvensis are the main host plants of hyalesthes obsoletus and play an important role in the epidemiology of bois noir of grapevines. the earliest survey, which was carried out to compare the phenology of nymphal instars on u. dioica and c. arvensis, had highlighted some problems in the identification of the instars. therefore, the correct identification of nymphs to species and instar level became a preliminary aim of this research. adults and nymphs attributable to ...201222360966
nonvolatile chemical cues affect host-plant ranking by gravid polygonia c-album females.in a multiple-choice test, the preference of egg-laying polygonia c-album (comma butterfly) females was studied for oviposition on plants bearing surrogate leaves treated with crude methanol extracts obtained from leaves of seven host-plant species: humulus lupulus, urtica dioica, ulmus glabra, salix caprea, ribes nigrum, corylus avellana, and betula pubescens. the ranking order of surrogate leaves treated with host-plant extracts corresponded well to that reported on natural foliage, except r. ...201222486046
an evaluation of the inhibitory effects against rotavirus infection of edible plant extracts.rotaviruses are the single most important cause of severe diarrhea in young children worldwide. the developments of specific, potent and accessible antiviral treatments that restrain rotavirus infection remain important to control rotavirus disease.201222834653
medicinal plants extracts affect virulence factors expression and biofilm formation by the uropathogenic escherichia coli.medicinal plants are an important source for the therapeutic remedies of various diseases including urinary tract infections. this prompted us to perform research in this area. we decided to focus on medicinal plants species used in urinary tract infections prevention. the aim of our study was to determine the influence of betula pendula, equisetum arvense, herniaria glabra, galium odoratum, urtica dioica, and vaccinium vitis-idaea extracts on bacterial survival and virulence factors involved in ...201222915095
screening antimicrobial activity of various extracts of urtica dioica.urtica dioica or stinging nettle is traditionally used as an herbal medicine in western asia. the current study represents the investigation of antimicrobial activity of u. dioica from nine crude extracts that were prepared using different organic solvents, obtained from two extraction methods: the soxhlet extractor (method i), which included the use of four solvents with ethyl acetate and hexane, or the sequential partitions (method ii) with a five solvent system (butanol). the antibacterial an ...201223342511
impact of vector dispersal and host-plant fidelity on the dissemination of an emerging plant pathogen.dissemination of vector-transmitted pathogens depend on the survival and dispersal of the vector and the vector's ability to transmit the pathogen, while the host range of vector and pathogen determine the breath of transmission possibilities. in this study, we address how the interaction between dispersal and plant fidelities of a pathogen (stolbur phytoplasma tuf-a) and its vector (hyalesthes obsoletus: cixiidae) affect the emergence of the pathogen. using genetic markers, we analysed the geog ...201223284774
anti-mycobacterial screening of five indian medicinal plants and partial purification of active extracts of cassia sophera and urtica dioica.to find out the anti-mycobacterial potential of cassia sophera (c. sophera), urtica dioica (u. dioica), momordica dioica, tribulus terrestris and coccinia indica plants against multi-drug resistant (mdr) strain of mycobacterium tuberculosis (m. tuberculosis).201323608375
[in vitro effect of ankaferd blood stopper®, a plant extract against mycobacterium tuberculosis isolates].treatment of drug-resistant mycobacterium tuberculosis infections requires combination of anti-tuberculosis drugs which have several toxic side effects. thus there is a need for safer and effective new drugs. ankaferd blood stopper® (abs), which is a mixture of plant extracts prepared from alpinia officinarum, glycyrrhiza glabra, thymus vulgaris, urtica dioica and vitis vinifera, has homeostatic and antibacterial effects. standard solutions of abs are already being used topically for post-trauma ...201323390904
carbohydrate binding properties of the stinging nettle (urtica dioica) rhizome lectin.the interaction of the stinging nettle rhizome lectin (uda) with carbohydrates was studied by using the techniques of quantitative precipitation, hapten inhibition, equilibrium dialysis, and uv difference spectroscopy. the carbohydrate binding site of uda was determined to be complementary to an n,n',n"-triacetylchitotriose unit and proposed to consist of three subsites, each of which has a slightly different binding specificity. uda also has a hydrophobic interacting region adjacent to the carb ...20133740853
high-antibacterial activity of urtica spp. seed extracts on food and plant pathogenic bacteria.the aim of this study was to comparatively evaluate antibacterial activities of methanol (metoh) and aqueous (dw) leaf (l), root (r) and seed (s) extracts of urtica dioica l. (ud; stinging nettle) and urtica pilulifera l. (up; roman nettle) on both food- and plant-borne pathogens, with total phenolic contents and dpph radical scavenging activities (drsa). metoh extracts of leaves and roots of u. dioica had the highest drsa. extracts with high antibacterial activity were in the order up-lmetoh (1 ...201323067263
where does the border lie: locally grown plants used for making tea for recreation and/or healing, 1970s-1990s estonia.traditional use of local wild and cultivated plants for making recreational tea in estonia often borders with the medicinal use of the same plants.201323994468
water-extractable magnesium, manganese and copper in leaves and herbs of medicinal plants.since herbal teas, infusions and decoctions prepared from medicinal plants are popular remedies, it remains a topical question whether these herbal drugs can be treated as sources of essential elements for humans, who often use them in their everyday diet. therefore, total and water-extractable contents of mg, mn and cu were determined in 41 leaves originating from four botanical species of plantago lanceolata, arctostaphyllos uva-ursi, rubus fruticosus and betula sp., as well as in 33 samples o ...201322574504
effect of cooking methods on antioxidant activity and nitrate content of selected wild mediterranean plants.wild edible plants (wep), traditionally consumed in the mediterranean diet, are considered a rich source of natural antioxidants but can also accumulate significant amount of nitrates. most wep are cooked before consumption, therefore, a study was conducted to evaluate the effects of boiling, steaming and microwave cooking processes on the total antioxidant activity (taa) and nitrate content of eight common wep. boiling caused the highest losses of taa, resulting in a reduction of the taa on dry ...201323701122
in vitro evaluations of cytotoxicity of eight antidiabetic medicinal plants and their effect on glut4 translocation.despite the enormous achievements in conventional medicine, herbal-based medicines are still a common practice for the treatment of diabetes. trigonella foenum-graecum, atriplex halimus, olea europaea, urtica dioica, allium sativum, allium cepa, nigella sativa, and cinnamomum cassia are strongly recommended in the greco-arab and islamic medicine for the treatment and prevention of diabetes. cytotoxicity (mtt and ldh assays) of the plant extracts was assessed using cells from the liver hepatocell ...201323606883
antihyperlipidemic effect of a polyherbal mixture in streptozotocin-induced diabetic rats.the effects of a polyherbal mixture containing allium sativum, cinnamomum zeylanicum, citrullus colocynthis, juglans regia, nigella sativa, olea europaea, punica granatum, salvia officinalis, teucrium polium, trigonella foenum, urtica dioica, and vaccinium arctostaphylos were tested on biochemical parameters in diabetic rats. the animals were randomized into three groups: (1) normal control, (2) diabetic control, and (3) diabetic rats which received diet containing 15% (w/w) of this mixture for ...201324383002
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