Publications

adsorption of steptococcal extracellular polysaccharides by hydroxyapatite.		1976	1067804
electrophoretic mobility of oral streptococci.		1976	1068652
interaction of inflammatory cells and oral bacteria: release of lysosomal hydrolases from rabbit polymorphonuclear leukocytes exposed to gram-positive plaque bacteria.		1976	1068661
correlation between streptococci of human dental plaques and dental caries.	plaque samples from 27 buccal tooth surfaces were obtained with sterile mccall curettes from available third molars. bacteriological sampling and biochemical tests were carried out to identify four groups of streptococci, i.e. str. mutans, str. spp., str. sanguis and str. mitis. clinical examinations carried out 6 months after the dental scrapings were taken showed a strong positive correlation between detectable lesions and str. mutans.	1976	1068669
[synthesis of extracellular polysaccharides in streptococcus mutans and streptococcus sanguis strains from the oral cavity].		1976	1070402
[selected microbial flora of patients with proximal caries].		1976	1077376
attributes of potential utility in differentiating among "group h" streptococci or streptococcus sanguis.		1976	1060637
physiological classification of oral viridans streptococci.	the human mouth harbors large numbers of a variety of greening streptococci. for many years the classification and nomenclature of these organisms have been confused, but recent studies have clarified the situation considerably. five distinct species can be distinguished among the oral streptococci s mutans, s sanguis, s mitior, s milleri, and s salivarius, and these may be identified using a simple scheme consisting of seven physiological tests. further subdivisions within these species may be ...	1976	1060638
streptococci of the oral cavity other than streptococcus mutans: an evaluation of some present knowledge.		1976	1060639
establishment and symbiosis of actinomyces viscosus, streptococcus sanguis and streptococcus mutans in germ-free osborne-mendel rats.		1976	1061641
[total bacterial count and the occurrence of streptococcus mutans and streptococcus sanguis in the air of various work areas].	in the various rooms of the würzburg dental school, the total germ contamination of the air and the incidence of s. mutans and s. sanguis strains was studied. the total number of organisms found as well as the number of the two polysaccharide-producing organisms varied considerably. the presence of the two streptococcal strains is not restricted to the air in dental surgeries. it is considered to be an additional risk that by far the highest incidence of the cariogenic s. mutans strain is found ...	1976	1062279
effect of a fluoride-containing chlorhexidine gel on bacteria in human plaque.	the effect on the plaque flora of a fluoride-containing chlorhexidine gel in mouthpieces was studied in seven subjects. use of the gel during a 3-month period resulted in a change in the pattern of sensitivity to cholorhexidine in the plaque flora as displayed by determination of the minimal inhibitory amount (mia) of the drug in agar diffusion assays. three months after the use of gel was discontinued, the mia value for plaque bacteria had returned to its original level. the relative proportion ...	1976	1062847
some serological cross-reactions between streptococcus mutans, s sanguis, and other dental plaque streptococci.	from the preliminary observations described in this report, the following conclusions may be drawn. when attempting to produce diagnostic antiserums specific for s mutans, s mitior, or s sanguis, care must be taken to eliminate cross-reactions as a result of antibodies against extracellular glucans or dextrans. other antigenic components, associated with the cell wall, may be common to different species. one soluble protein or polypeptide antigen normally present in s sanguis and s mitior may al ...	1976	1063153
effect of growth medium on amino acid pools of oral streptococci.		1976	1063769
susceptibility of some plaque microorganisms to chemotherapeutic agents.	investigators have used chemotherapeutic agents topically for plaque control without knowing the drug concentration necessary to inhibit the growth of odontopathic microorganisms. s mutans, s sanguis, a viscosus and a naeslundii are important components of the plaque flora. the minimal inhibitory concentrations (mic) and minimal bactericidal concentrations (mbc) of niddamycin, vancomycin, bacitracin, and kanamycin were determined for each organism in liquid culture. these antibiotics were select ...	1976	1064600
potassium requirement of oral streptococci.		1976	1064626
affinity for hydroxyapatite of salivary substances inducing aggregation of oral streptococci.		1976	1058743
streptococcus sanguis: a model in the application in immunochemical analysis for the in situ localization of bacteria in dental plaque.	a review of the development of the serology of s sanguis has been presented. this species contains a group-specific antigen designated a, which appears to be a glycerol teichoic acid. it is suggested that this antigen be designated the lancefield group h antigen. in addition, two major serotypes based on distribution of other surface antigens have been demonstrated. the grouping antiserums for s sanguis have been used to localize these bacteria in ultrastructural sections of intact dental plaque ...	1976	812892
selective adherence as a determinant of the host tropisms of certain indigenous and pathogenic bacteria.	the relationship between the selective abilities of bacteria to adhere and their predilections for colonizing different mammalian hosts was investigated by using bacteria indigenous to the tongue dorsum of humans and rats as models. streptococcus salivarius and s. sanguis averaged 22.6 and 2.8%, respectively, of the cultivable bacteria recovered from swab samples of the tonges of five humans, but these organisms were not indigenous on the tongues of rats (charles river strain). s. faecalis and s ...	1976	814100
production of mannitol by streptococcus mutans.		1976	823929
treatment of bacterial endocarditis 1976.		1976	824117
transformation of streptococcus sanguis challis by plasmid deoxyribonucleic acid from streptococcus faecalis.	plasmid deoxyribonucleic acid (dna) from streptococcus faecalis, strain ds5, was transferred to the challis strain of streptococcus sanguis by transformation. two antibiotic resistance markers carried by the beta plasmid from strain ds5, erythromycin and lincomycin, were transferred to s. sanguis at a maximum frequency of 1.8 x 10-5/colony-forming unit. approximately 70% of the covalently closed circular dna isolated from transformant cultures by dye buoyant density gradients was shown to be hyb ...	1976	824275
initial colonization of teeth in monkeys as related to diet.	the initial phases of plaque development on nonretentive tooth surfaces were studied bacteriologically in macaca irus monkeys fed by stomach tube and provided with various oral supplements. except for the oral implantation of streptococcus mutans in some of the animals, the oral flora was not changed prior to the studies. dental plaque was allowed to develop on initially cleaned tooth surfaces for 3 to 5 h. plaque samples were collected and cultured on a number of selective and nonselective agar ...	1976	825462
further studies of twitching streptococcus sanguis isolated from the human throat. isolation of strains with a new antigen.	alpha-haemolytic streptococci, classified as streptococcus sanguis, with spreading growth due to twitching mobility were isolated from 41% of 121 swab cultures from the human pharynx. sixty-five out of 70 isolates with spreading growth belonged to lancefield's group h, while 5 isolates constituted a new serological entity. none of 159 non-spreading alpha-haemolytic streptococci isolated from the same cultures possessed either of these antigens. an examination of strains of types i, ii and i/ii d ...	1976	826110
a leucocyte migration study on the cell-mediated immunity against adult human oral mucosa and streptococcal antigens in patients with recurrent aphthous stomatitis.	in vitro demonstration of cell-mediated immunity (cmi) against adult human oral mucosa antigen (ahom) and streptococcal antigens was accomplished by means of the leucocyte migration test (lmt) in patients with recurrent aphthous stomatitis (ras). if antigenic extracts of ahom, streptococcus sanguis strain 2a or streptococcus pyogenes strain m5 were used in the lmt experiments, the distribution of migration indices (mi) over patients with ras differed significantly from the distribution over the ...	1976	826113
a method for studying adherence of oral streptococci to solid surfaces.	the adherence of different streptococci to test pieces of glass, human enamel and whale dentin carried in the mouth or immersed in saliva or bacterial suspensions was studied by examining the number and frequency of microorganisms which were selectively desorbed by a standardized washing technique. the results obtained from in vivo and in vitro experiments were similar in principle. the proportion of streptococci obtained in the first washing resembled that found in the saliva, but with more vig ...	1976	766151
an apparatus for the continuous culture of micro-organisms on solid surfaces with special reference to dental plaque.		1976	780331
streptococci and aerococci associated with systemic infection in man.	a collection of 820 isolates of streptococci and aerococci from human blood or internal organs was classified by means of a set of cultural and biochemical tests. of these, 719 (712 streptococci and 7 aerococci) were from patients believed to be suffering from a systemic infection: endocarditis 317; a purulent lesion in an internal organ ("purulent disease") 152; bacteriaemia 250. the endocarditis streptococci included members of all recognisable taxa, but only certain of these were common: stre ...	1976	785000
comparison of cellular and humoral immunity against streptococcal and adult human oral mucosa antigens in relation to exacerbation or recurrent aphthous stomatitis.	cell-mediated immunity (cmi) and humoral mediated immunity (hmi) against streptococcal and adult human oral mucosa (ahom) antigens were investigated in patients with inactive and active recurrent aphthous stomatitis (ras). the cmi and hmi were examined by means of the leucocyte migration test (lmt) and a double layer immunofluorescence (if) technique. the cmi against streptococcus sanguis strain 2a, streptococcus pyogenes strain m5, and ahom was significantly increased in inactive and active ras ...	1976	785943
[biological activity of secretory iga --particularly antibacterial immunity as an example-- (author's transl)].		1976	792366
turku sugar studies x. occurrence of polysaccharide-forming streptococci and ability of the mixed plaque microbiota to ferment various carbohydrates.	dental plaque samples collected from the subjects during the last 20 months of the 2 year trial were subjected to quantitative and qualitative analysis of the occurrence of s. mutans, s. sanguis, s. salivarius and the total growth on phenol red agar. lyophilized plaque samples were homogenized and incubated on a sucrose containing medium under anaerobic conditions. in addition, the ph-values were measured after incubation of the mixed plaque flora in media containing 1% respectively xylitol(x), ...	1976	797222
occurrence and distribution of sucrose-metabolizing enzymes in oral streptococci.	specific growth rates, growth yields, and the level and cellular distribution of three sucrose-metabolizing enzyme activities were determined for seven oral streptococci (streptococcus mutans strains e49, bht, 10449, sl-1, and lm-7, s. sanguis 10558, and s. salivarius 25975). cultures were grown in a fermentor at ph 6 with either 20 mm glucose or 10 mm sucrose. generation times varied between 21 and 70 min. whereas some strains grew 10 to 50% more slowly with sucrose than with glucose, others di ...	1976	971954
recurrent aphthous ulceration.		1976	971977
blastogenic response of human lymphocytes to oral bacterial antigens: characterization of bacterial sonicates.	soluble sonicate supernatant preparations were made from actinomyces viscosus (atcc 19246), a. naeslundii (atcc 12104), two strains of veillonella alcalescens (strain hv-1 and a human oral isolate), streptococcus sanguis (atcc 10556), s. mutans (strain 6715-t2), bacteroides melaninogenicus (strain k110), and leptotrichia buccalis (isolated from human dental plaque). these supernatants were characterized with reference to their chemical and antigenic components and their biological activity deter ...	1976	977126
use of hydroxyapatite-coasted glass beads for preclinical testing of potential antiplaque agents.	methods for rapid preclinical testing of antiplaque agents in vitro using hydroxyapatite (ht)-coated glass beads are described. the assays developed could reliably detect (i) prevention of growth in the culture fluid or on the ht surfaces, (ii) the effect of transient exposure of a bactericidal agent on the viability of cells in a preformed bacterial mat, (iii) reversible adsorption of a bactericidal agent on an ht surface, and (iv) the ability of an agent to inhibit adsorption of streptococcus ...	1976	984818
transforamtion of twitching strains of streptococcus sanguis.	ninety-five strains of s. sanguis, 90 of which were twitching, were screened for competence in transformation with dna from the "challis" strain. seventy-two strains, 68 of sero-group h and 4 of the provisional group 10043, were competent. fourteen of the competent strains and all strains which appeared to be incompetent were tested with dna from 3 other strains. the 14 competent strains were transformed by all the 3 dnas. one of the apparently incompetent strains was transformed by autologous d ...	1976	998260
haemagglutination of twitching streptococcus sanguis.	among 86, mostly twitching, polarly fimbriated strains of streptococcus sanguis, 55 agglutinated guinea pig erythrocytes (gpe) after cultivation in todd-hewitt broth (th), and 21 strains agglutinated gpe only after growth in th with 10% horse serum (ths). two of the positive strains were non-twitching and unfimbriated. ten strains failed to haemagglutinate. among 5 twitching strains belonging to the 10043 group, 3 agglutinated gpe after growth in th and 2 only after growth in ths. among 35 non-t ...	1976	998261
effect of warfarin on the induction and course of experimental endocarditis.	the effect of warfarin treatment on an experimental endocarditis was studied in rabbits. warfarin had no effect on the induction of a streptococcus sanguis infection in catheter-induced endocardial vegetations, and the course of this infection was also unaltered. however, warfarin treatment resulted in rapidly progressive bacteremia, probably due to impaired circulation in clearing organs such as the lungs, liver, and spleen. warfarin also reduced the survival time of the infected rabbits, in wh ...	1976	1002298
interaction of inflammatory cells and oral microorganisms. ii. modulation of rabbit polymorphonuclear leukocyte hydrolase release by polysaccharides in response to streptococcus mutans and streptococcus sanguis.	the release of lysosomal hydrolases from polymorphonuclear leukocytes (pmns) has been postulated in the pathogenesis of tissue injury in periodontal disease. in the present study, lysosomal enzyme release was monitored from rabbit peritoneal exudate pmns exposed to streptocccus mutans or streptococcus sanguis. s. mutans grown in brain heart infusion (bhi) broth failed to promote significant pmn enzyme release. s. sanguis grown in bhi broth, although more effective than s. mutants, was a weak sti ...	1976	1002299
viridans streptococci associated with periapical dental abscesses.	viridans streptococci isolated in apparently pure culture from periapical dental abscess have been examined. it has been found that each abscesses is associated with only one type of a given species of streptococcus. the distribution of types of strep. mitis found in abscesses differed from the distribution in healthy mouths, but no particular type occurred significantly more often in abscesses than in mouths.	1976	1017878
enhanced transformability with heterospecific deoxyribonucleic acid in a streptococcus sanguis mutant impaired in ribonucleic acid polymerase activity.	we have induced with nitrosoguanidine in streptococcus sanguis a mutation conferring inability to grow and synthesize ribonucleic acid (rna) at 42 c, the optimal temperature for growth and rna synthesis in the parental strain. the mutation (ts) is transferable via transforming deoxyribonucleic acid (dna) and is replaceable by its wild-type allele with fairly high efficiency in transformation reactions. the ts mutation is unlinked to the sites of mutation conferring resistance of rifampin (rifr) ...	1976	1047061
antibiotic susceptibilities of streptococci from the mouth and blood of patients treated with penicillin or lincomycin and clindamycin.	patients undergoing dental extractions were non-randomly allocated to three groups, one of which received no antibiotic, one benzylpenicillin followed by oral penicillin for 5 days, and the third intramuscular lincomycin followed by oral clindamycin. dental extraction was performed at the beginning of the course of chemotherapy. streptococci were isolated from the extracted teeth, from blood cultures collected before and immediately after dental extraction, and from sutures removed from the gums ...	1976	1050385
viridins, bacteriocins of alpha-hemolytic streptococci: isolation, characterization, and partial purification.	bacteriocin-like activities were detected in 78% of 120 alpha-hemolytic streptococcal isolates. inhibitory substances from three such isolates (one streptococcus sanguis strain and two s. mitis strains) were investigated further and termed viridins (a, b, and c). the viridins were unique among bacteriocins of gram-positive bacteria in that they inhibited many gram-negative bacteria in addition to inhibition of a variety of gram-positive organisms. viridins were obtained in a cell-free state only ...	1976	1259394
chemotherapy of experimental streptococcal endocarditis. v. effect of duration of infection and retained intracardiac catheter on response to treatment.	the dynamics of infection and response to penicillin g (p) or combined p plus streptomycin (s) therapy were studied in a rabbit model of penicillin-sensitive streptococcus sanguis endocarditis. increased delay between infection and initiation of treatment required longer duration of therapy to effect a cure. irrespective of the interval between infection and onset of therapy, p combined with s regularly eliminated streptococci from endocardial vegetations more rapidly than p alone, both in the p ...	1976	1270880
relationship of the cell wall composition of group h streptococci and streptococcus sanguis to their serological properties.	previous studies indicated the a antigen was widely distributed among strains of streptococcus sanguis and the group h streptococci. the cell walls of strains containing this antigen had moderate to large quantities of rhamnose, small amounts of phosphorus, and little to no ribitol. the molar ratios of the peptidoglycan amino acids and hexosamines suggested a di-alanyl cross bridge. the homogeneity of the walls of these strains suggested that serological group h can be considered synonymous with ...	1976	1279002
dextran-mediated interbacterial aggregation between dextran-synthesizing streptococci and actinomyces viscosus.	streptococcus sanguis and streptococcus mutans bind to the surface of actinomyces viscosus, producing large microbial aggregates. aggregates form rapidly and are not easily dissociated by vigorous mixing. the binding is mediated by dextran. glucose-grown streptococci will not aggregate unless they are first mixed with high-molecular-weight dextran. aggregation is induced with dextrans isolated from leuconostoc, s. sanguis, or s. mutans. sucrose-grown streptococci will adhere to a. viscosus witho ...	1976	1279004
comparative ultrastructure of selected oral streptococci: thin-sectioning and freeze-etching studies.	the ultrastructure of streptococcus mutans, serotypes a-e, s. sanguis, s. mitis, and s. salivarius hht, were examined by the techniques of thin-sectioning and freeze-etching. the cell walls varied in width between 15 and 46 nm and were covered with an electron-dense fibrillar or fuzz layer. the cytoplasmic membrane was in close association with numerous mesosomes which were, in turn, either closely associated or in contact with the bacterial chromosome. in freeze-etch replicas, the outermost lay ...	1976	177163
canker sores and cold sores their diagnosis and treatment.		1976	180593
extracellular glucans produced by oral streptococci.		1976	180941
effect of ph on competence development and deoxyribonucleic acid uptake in streptococcus sanguis (wicky).	streptococcus sanguis (wicky) cells, strain we4, developed little or no competence and failed to autolyze in permissive conditions when treated with competence factor (cf) below ph 7.0. this lack of activity was directly correlated with the inability of the cells to bind or take up cf at ph values of 5.5, 6.0, and 6.5. on the other hand, competent cells bound deoxyribonucleic acid molecules maximally below ph 7.0 and transformed maximally at ph 6.5. deoxyribonucleic acid was optimally bound to c ...	1976	4422
ph and eh in single and mixed culture bacterial plaque in an artificial mouth.		1976	5393
ph changes during culture of human dental plaque streptococci on mitis-salivarius agar.		1976	8030
autolysis in strains of viridans streptococci.	seven strains of viridans streptococci of the species streptococcus sanguis, s. mutans and s. mitis were investigated for autolysis. the effect of ph, salt concentration and temperature on the autolytic process was studied in na2hpo4/nah2po4 buffer. whole cells and walls of all strains autolysed most rapidly at ph values above 7. autolysis of whole cells of s. sanguis and one strain of s. mitis (atcc15909) was maximal in 0-05 to 0-2 m buffer, while the two s. mutans strains and s. mitis atcc1591 ...	1976	10349
purification and some properties of free and cell-associated dextransucrase from streptococcus sanguis.	dextransucrase of streptococcus sanguis occurred in cell-free and cell-associated forms. cell-free dextransucrase was purified by four successive chromatographies on bio-gel p 60, deae-cellulose, and bio-gel p 200 from the culture supernatant. the purification of cell-associated dextransucrase was made from the pellet of streptococcus sanguis culture. bacterial pellet was extracted with 1 m phosphate buffer (ph 6.0) and chromatographied by using an immunosorbent column. the two enzymes gave sing ...	1976	11837
lactate formation at various ph levels by the wild strain of streptococcus mutans pk 1, its variant, and s sanguis.		1976	12197
glucosyltransferase production by streptococcus sanguis 804 (nctc 10904).	streptococcus sanguis 804 (nctc 10904) was grown ih batch culture at constant ph. and the glucosyltransferase activity of the supernatant was assayed over a 40-h growth period. the optimum ph for enzyme production was 7.0 to 7.2. during growth of the culture, three reproducible phases of enzyme activity were observed. the polysaccharides synthesized during each of these phases were characterized as dextran-like glucans by analysis of acid hydrolysates, gas-liquid chromatography, and a specific a ...	1977	13040
characterization of group h streptococcal temperate bacteriophage phi 227.	phi 227, a temperate phage from a group h streptococcus (streptococcus sanguis), was propagated vegetatively in group h strain wicky 4-eryr, and its characteristics were determined. a procedure dependent on multiplicity of infection, incubation time, and treatment of crude lysates with diatomaceous earth was found to optimize phage yield, resulting in titers of 1 x 10(10) to 2 x 10(10) pfu/ml. without prior treatment with diatomaceous earth, subsequent purification procedures (methanol, ammonium ...	1977	15133
plaque formation by streptococci in an artificial mouth and factors influencing colonization.		1977	18435
secretion of lipids induced by inhibition of peptidoglycan synthesis in streptococci.	inhibition of peptidoglycan synthesis causes an immediate and massive secretion of both newly synthesized and "old" lipids from several species of bacteria, including streptococci, staphylococcus epidermidis, and bacillus subtilis. lipid secretion occurs in the absence of detectable bacterial lysis. this novel phenomenon was examined in more detail in three strains of streptococci: s. sanguis (group h), s. pyogenes (group a), and s. pneumoniae. the secretion of lipids is specifically induced by ...	1977	21168
acid production from lycasin, maltitol, sorbitol and xylitol by oral streptococci and lactobacilli.	the acid production from maltitol was compared with the acid production from hydrogenated starch hydrolysate (lycasin), sorbitol and xylitol by a number of oral strains and reference strains of streptococcus mutans, s. sanguis, s. salivarius, s. mitior, s. milleri, s. faecalis, s. faecium, s. avium, lactobacillus casei and l. salivarius. the polyols were added to a final concentration of 1.0% to two different basal media. incubation was performed at 37 degrees c for 7 days after which the ph was ...	1977	21508
enamel microhardness and fluoride uptake underneath fermenting and non-fermenting artificial plaque.	washed cells of streptococcus sanguis were used to form artificial plaque on the surface of bovine enamel and incubated underneath buffer solutions, initial ph 6, for 36 h at 37 degrees c. the decrease in the microhardness of the enamel surface under fermenting "plaque" could be prevented with fluoride. enamel under a fermenting "plaque" took up significantly more (p less than 0.0u) fluoride than enamel under a non-fermenting "plaque" (initial f- in buffer: 10 parts/10(6)). the artificial plaque ...	1977	22924
effect of ph and counter ions on the zeta-potential of oral streptococci.		1977	23746
bacteriocin-like activities of human dental plaque flora against oral anaerobic microorganisms.		1977	26477
scanning electron microscopy of heart-valve vegetations.		1977	71629
reduction in proportions of dental plaque streptococci following a 5 day topical kanamycin treatment.		1977	137306
interbacterial aggregation of actinomyces naeslundii and dental plaque streptococci.		1977	137307
predominant cultivable microbiota in periodontosis.		1977	138729
bacteriological studies of developing supragingival dental plaque.		1977	138733
streptococcus sanguis and streptococcus salivarius in early plaque formation on plastic films.		1977	143517
human saliva as a nitrogen source for oral streptococci.		1977	264243
competitive binding among oral strptococci to hydroxyapatite.	the relative affinity of various oral streptococci for hydroxyapatite (ha) differed widely. streptococcus mutans affinity for dextran-coated ha was the highest of all the streptococci to any ha coating. s salivarius had the lowest affinity, and s sanguis affnity was higher then s miteor for saliva-coated ha. competition for binding sites on saliva-dextran-coated, dextran-coated ha. hhwever, competition between this pair was not for the same binding site but for closely associated sites.	1977	264883
interaction of streptococcal aggregating factors with thiol-and disulphide-reactive compounds.		1977	266858
antagonistic substances produced by streptococci from human dental plaque and their significance in plaque ecology.		1977	267511
[problems of the relationship between oral hygiene and dental caries].		1977	267561
microbial characterization of an experimental cariogenic plaque in man.	experimentally induced plaque seemed to originate by direct contact inoculation from the vestibular mucosa and saliva. during the next seven days, this plaque developed its own characteristics. populations of streptococcus mutans usually less than 2% of total streptococci population in plaques that were less than three days old, increased between days 3 and 7. proportions of s sanguis, high in early samples, decreased after day 3. populations of s salivarius, which usually outnumbered other stre ...	1977	268335
comparison of antiplaque agents using an in vitro assay reflecting oral conditions.	an in vitro assay is described using saliva-treated bovine enamel slabs for determining the potential of chemotherapeutic agents to adsorb to tooth surfaces and act against plaque-forming bacteria. chlorhexidine was found to inhibit the formation of in vitro plaque by actinomyces viscosus, a naeslundii, streptococcus mutans and s sanguis. actinobolin was found to have marked antibacterial properties but limited adsorptive qualities.	1977	268336
inhibition of glucose utilization in oral streptococci by low concentrations of fluoride.		1977	269750
[streptococcal flora of normal and inflamed gingival pockets].		1977	269783
effect of fissure sealing on the microflora in occlusal fissures of human teeth.		1977	270316
activation of the complement system by some gram-positive oral bacteria.		1977	270324
the salivary concentration of streptococci mutans and streptococci sanguis and their colonization of artificial tooth fissures in man.		1977	271488
electron microscopic study of the interaction of oral microorganisms with polymorphonuclear leukocytes.		1977	272141
transformation of streptococci to streptomycin resistance by oral streptococcal dna.		1977	272159
effect of bacterial products on inflammatory reactions in the dental pulp.	culture filtrates (extracellular components) and material obtained from disintegrated cells (intracellular components) of cultured plaque bacteria were studied for their capacity to induce inflammatory reactions in the dental pulp. class v cavities were prepared on the buccal surface of 94 teeth: 42 test and 52 control teeth in six adult monkeys. lyophilized bacterial components were sealed into the test cavities either alone or following an 8-h topical application of a solution of the same comp ...	1977	402688
sorption of streptococci to glass: effects of macromolecular solutes.	macromolecular solutes (albumin, concanavalin a, whole saliva, serum) caused impaired sorption of streptococcus faecium and streptococcus sanguis to glass. the inhibitory effect resided chiefly with interactions of the solutes with the glass surface. in the case of sorption of s. sanguis to glass in the presence of parotid fluid, the inhibitory effect was counteracted by a specific attachment of s. sanguis cells mediated by some component(s) of the parotid fluid. agglutination of the test organi ...	1977	402790
haemagglutination activity of plaque-forming bacteria.		1977	403006
a sequential bacteriological and serological investigation of rhesus monkeys immunised against dental caries with streptococcus mutans.	in a serial investigation of the effects of immunisation with s. mutans in rhesus monkeys maintained on a "human" type of cariogenic diet, the numbers of s. mutans in cervical plaque, crevicular-fluid washings, fissures of teeth, and in saliva were lower in immunised animals than in sham-immunised controls. immunisation also caused a delay in initial colonisation and a slowing of the rate of colonisation with s. mutans. these bacteriological changes were associated with a reduction in the smooth ...	1977	404427
loss of antibody activity in human immunoglobulin a exposed extracellular immunoglobulin a proteases of neisseria gonorrhoeae and streptococcus sanguis.	immunoglobulin a (iga) proteases are extracellular enzymes elaborated by neisseria gonorrhoeae, n. meningitidis, and streptococcus sanguis. these enzymes each cleave human iga1 at a critically situated prolyl-threonyl peptide bond to yield fab alpha and fc alpha fragments. to study their effect on the antibody activity of human iga, we enzymatically digested a group of five human iga monoclonal immunoglobulins with high-titer rheumatoid factor or cold agglutinin activity and human serum macroamy ...	1977	407159
sucrose metabolism by prominent members of the flora isolated from cariogenic and non-cariogenic dental plaques.	sucrose metabolism by resting-cell suspensions of pure cultures of representative members of the predominant cultivable flora isolated from cariogenic and non-cariogenic dental plaque was investigated by means of radiochemical techniques. streptocococcus mutans utilized sucrose at a considerably faster rate than s. sanguis, s. mitis, actinomyces viscosus, a. naeslundii, or lactobacillus casei, forming lactic acid, intracellular polysaccharide, insoluble extracellular glucan, and lactic acid from ...	1977	407163
serum dilution test for bactericidal activity. ii. standardization and correlation with antimicrobial assays and susceptibility tests.		1977	408424
antiplaque potential of topical stannous fluoride.	sterile enamel samples treated by topical application of 10% stannous fluoride were incubated with s mutans and s sanguis respectively and with a mixed culture to which l casei had been added. the results were compared with sterile nonfluoridated enamel samples subjected to the same procedures. the parameters compared were postincubation ph values, bacterial concentrations on the surfaces, and enamel surface alterations. stannous fluoride treated samples consistently yielded higher ph readings t ...	1977	409742
serum antibodies to plaque bacteria in subjects with dental caries and gingivitis.	correlations were sought between indices of gingival inflammation and dental caries experience and serum antibody titers to five species of oral bacteria. the material comprised 53 young adult males. a statistically significant, negative correlation was observed between the antibody titer to a pool of veillonella strains and dental caries experience. multiple regression analyses failed to reveal significant associations between periodontal disease and serum antibody titers. however, the data sug ...	1977	320647
reduction of dental decay in rampant caries individuals following short-term kanamycin treatment.	a week of kanamycin gel treatment before and after the placement of dental restorations, compared to a placebo gel treatment, significantly reduced the levels of cultivable bacteria, s mutans and s sanguis, in the plaque samples collected immediately after the completion of the gel treatments, and was associated with a 46% reduction in new carious surfaces in the 14- to 37-month period following the gel treatment.	1977	323316
survival of bacteria from human dental plaque under various transport conditions.	the effects of transport media, temperature, and anaerobiosis on the survival of bacteria from human supragingival dental plaque were studied. individual samples were obtained by passing sterile, unwaxed dental floss through the interproximal spaces. the plaque-bearing portion of floss was immediately placed in vials containing reduced transport fluid, viability-preserving microbistatic medium, or reduced salt solution transport fluid. plaque samples were dispersed by ultrasonic oscillation, ser ...	1977	332708
measurement and synthesis of insoluble and soluble dextran by streptococcus mutans.	total and insoluble dextransucrase activities of 10 strains of oral streptococci were measured by a modified filter disk assay. strains that were nonadherent to hard surfaces had only low levels of insoluble dextransucrase activity. a physical rather than metabolic mechanism is suggested to explain the decreased insoluble and increased soluble activities observed when dextran t-10 is added to the media.	1977	336659
recurrent aphthous stomatitis: clinical characteristics and evidence for an immunopathogenesis.	recurrent aphthous stomatitis is one of the most common diseases affecting the oral mucosa, and one of its variants is the most painful affliction of the oral mucosa. the lesions of recurrent aphthous stomatitis can be manifested as part of a broad spectrum of clinical disease ranging from the common minor aphthous ulcers to behçet's syndrome. differential diagnosis, although not often difficult, must include many conditions capable of producing erosive and ulcerative oral mucosal lesions. the s ...	1977	336797
new method for obtaining iga-specific protease.	a simple method for obtaining an active preparation of iga-specific protease from a bacterial source is presented. in this method streptococcus sanguis was inoculated onto the surface of a dialysis membrane on nutrient agar. following growth, the membrane was removed from the agar surface and washed in a small volume of buffer. a solution with protease activity against iga1 monoclonal proteins was obtained by clarification of the wash and appeared to be similar to enzyme preparations obtained by ...	1977	591723
interaction of hydroxyapatite and protein-coated hydroxyapatite with streptococcus mutans and streptococcus sanguis.	the present study showed that s. mutans and s. sanguis behaved like negatively-charged particles in their interaction with hydroxyapatite in vitro. phosphate in the system inhibited bacterial uptake by apatite, whereas calcium increased the uptake. a layer of acidic protein inhibited the uptake of bacteria by hydroxyapatite. the opposite was true when a basic protein was first adsorbed to the apatite. a saliva film on the apatite decreased the uptake of bacteria, supporting the view that acidic ...	1977	602782
the microbiology and biochemistry of plaque, saliva, and drinking water from two communities with contrasting levels of caries in colombia, s.a.		1977	24649
inhibition of glucosyltransferase by human salivary immunoglobulin a.	purified glucosyltransferase isolated from streptococcus sanguis omz 9 and different immunoglobulin a from saliva, saliva pellet, and dental plaque were used to study enzyme-antibody interactions. a strong inhibition of glucosyltransferase activity was obtained with the different immunoglobulin a fractions.	1977	832903