Publications

spotted fever group rickettsiosis in japan.	the acute febrile disease with characteristic rash encountered in tokushima prefecture was proved to be a spotted fever group rickettsiosis, which showed a significant rise in agglutinins to both proteus ox2 and ox19 and significantly high levels of cf antibodies to rickettsia akari and rickettsia rickettsii.	1985	3934436
[effects of thymosin on the humoral immune response to antibody-dependent cell cytotoxicity].		1985	4065002
rickettsiae and hosts.	protective immunity to rickettsia tsutsugamushi in a murine model is dependent upon the development of cell mediated immunity, as demonstrated by lymphocyte transfer, production of lymphokines and -interferon by thymus-derived lymphocytes, activation of macrophages by lymphokines and demonstration of delayed-type hypersensitivity response following exposure to these organisms. infection of mice with small numbers of rickettsia typhi inoculated by a peripheral route leads to a more complex patter ...	1985	2408453
studies on the mechanics of the normal human middle ear.	the middle ear was studied in temporal bone preparations using a laser-doppler interferometer. for measurements at a sound level of 80 db spl this method proved to be very reliable, as was shown by good reproducibility of results in experiments over more than 6 hours. the vibrations of the tympanic membrane and stapes footplate were studied from 200 hz to 10 khz and the results demonstrate a piston-like movement of the stapes footplate up to 120 db spl. the damping effect of the normal ear is lo ...	1986	3536194
hydrolysis of all gangliosides, including gm1 and gm2, on thin-layer plates by vibrio cholerae neuraminidase.		1986	3760066
effects of ouabain on cytosolic calcium in lymphocytes, platelets and adrenomedullary cells.	it has been suggested that a circulating inhibitor of na/k atpase can stimulate natriuresis and cause vasoconstriction in essential hypertension by stimulating transmembrane na/ca exchange to produce increased cytosolic concentrations of ionized calcium ([ca++]i) in renal tubular and arteriolar smooth muscle cells. if this inhibitor affected [ca++]i in all cell types, then clinical assays for its presence could be applied to easily accessible cells such as blood cells or platelets, and the inhib ...	1987	3429864
helicase properties of the escherichia coli uvrab protein complex.	the escherichia coli uvra protein has an associated atpase activity with a turnover number affected by the presence of uvrb protein as well as by dna. specifically, the structure of dna significantly influences the turnover rate of the uvrab atpase activity. double-stranded dna maximally activates the turnover rate 10-fold whereas single-stranded dna maximally activates the turnover rate 20-fold, suggesting that the mode of interaction of uvrab protein with different dnas is distinctive. we have ...	1987	3035542
perturbation of differentiated functions in vivo during persistent viral infection. iii. decreased growth hormone mrna.	lymphocytic choriomeningitis virus (lcmv) persistent infection that results from the inoculation of c3h/st newborn mice causes growth hormone (gh) deficiency and associated disease characterized by both reduced weight and serum glucose levels. molecular analysis of pituitary nucleic acids shows gh deficient mice have, on average, fivefold reduced levels of gh mrna although the histopathology of such gh producing cells is normal. northern blots indicate that the length of gh mrna is comparable in ...	1987	3811236
addition of monoclonal antibodies specific for rickettsia akari to the rickettsial diagnostic panel.	monoclonal antibodies were produced from mice infected with rickettsia akari (the etiologic agent of rickettsialpox) and evaluated for specificity in indirect fluorescent-antibody tests with 23 different rickettsial antigens. of the nine antibodies that were evaluated, two were specific for r. akari and four reacted with r. akari and all other spotted fever group rickettsiae. the remaining three antibodies reacted with some, but not all, members of the spotted fever group. none of the antibodies ...	1988	3183012
expression of heme oxygenase gene in rat and human liver.	developmental changes of microsomal heme oxygenase were studied. in human fetal liver, the enzyme activity was 8 times higher than that detected in the adult liver. on the other hand, adult livers contained 4 times more cytochrome p450 than fetal livers. elevated heme oxygenase activity in fetal liver was not due to modulators present in the microsomes. similar to human, rat fetal liver also contained high enzyme activity which appeared to be regulated at the transcriptional level. hybridization ...	1988	3342043
a new approach to the quality control of steroid receptor assays.	lyophilized cytosols prepared from calf uterus and human breast tumor tissue are commonly used to assess the reliability of routine steroid receptor assays. however, preanalytical error (sample preparation, storage, homogenization) cannot be detected in this way. participating laboratories were asked to mail us all their receptor results obtained over a four-month interval, and to include some information about the patients involved (age, menopausal status, nodal status). after verifying the hom ...	1988	3168219
[experimental chemo- and chemoendocrine therapy of human breast carcinomas serially transplanted into nude mice].	four human breast carcinoma strains serially transplanted into nude mice were used for the experimental chemotherapy and combination chemoendocrine therapy. whereas three of these strains (mcf-7, br-10, tm-61) possessed cytosol estrogen receptor (erc) and were dependent on estradiol for the tumor growth, the other strain (mx-1) without erc was hormone independent. for the chemotherapy, mitomycin c (mmc), adriamycin (adm), cyclophosphamide (cpm) and 5-fluorouracil (5-fu) were administered 3 times ...	1988	3129645
molecular biological characterization of equine herpesvirus type 1 (ehv-1) isolates from ruminant hosts.	isolates of equine herpesvirus type 1 (ehv-1) originating from affected antelope and cattle were compared with reference ehv-1 and ehv-4 isolates and were characterized. based on cross-neutralization, dna restriction profiles and blot-hybridization data these isolates could be characterized as ehv-1. one isolate (from an antelope) with a different restriction profile showed significant dna homology with ehv-1, partial homology with ehv-4, and little or no homology with ehv-2 and hsv-1 dnas. blot ...	1988	2849252
ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase in rat and bovine brain tissues.	inositol 1,4,5-trisphosphate (ins p3) 3-kinase catalyzes the atp-dependent phosphorylation of ins p3 to inositol 1,3,4,5-tetrakisphosphate (ins p4). ca2+/calmodulin (cam)-sensitivity of ins p3 3-kinase was measured in the crude soluble fraction from rat brain and different anatomic regions of bovine brain. kinase activity was inhibited in the presence of egta (free ca2+ below 1 nm) as compared to ca2+ (10 microm free ca2+) or ca2+ (10 microm free ca2+) and cam (1 microm). ca2+-sensitivity was al ...	1988	2838022
effect of reduced energy metabolism and reperfusion on the permeability and morphology of the capillaries of an isolated rete mirabile.	the effects of reduction in energy metabolism were explored in the eel rete mirabile, an organ composed predominantly of capillaries. in vitro experiments showed that glycolysis is the major pathway of energy production in this capillary tissue, and that iodoacetate, kcn, and low po2 in combination markedly reduce its atp generation. when in situ energy generation was inhibited by this combination during countercurrent perfusion of the arterial and venous capillaries of the rete, an approximate ...	1989	2912596
human aldehyde dehydrogenase: coenzyme binding studies.	the binding of nadh and nad+ to the human liver cytoplasmic, e1, and mitochondrial, e2, isozymes at ph 7.0 and 25 degrees c was studied by the nadh fluorescence enhancement technique, the sedimentation technique, and steady-state kinetics. the binding of radiolabeled [14c]nadh and [14c]nad+ to the e1 isozyme when measured by the sedimentation technique yielded linear scatchard plots with a dissociation constant of 17.6 microm for nadh and 21.4 microm for nad+ and a stoichiometry of ca. two coenz ...	1989	2775711
absence of genetic linkage of charcot-marie-tooth disease (hmsn ia) with chromosome 1 gene markers.	we previously reported a large charcot-marie-tooth family not linked to the duffy blood group marker, supporting the existence of genetic heterogeneity in this neuropathy. in order to investigate the possibility of another disease locus on chromosome 1, we analyzed this family further, using dna polymorphisms of 6 genes. absence of linkage makes a second disease locus on chromosome 1 unlikely.	1989	2725880
positive weil-felix reactions in a case of rickettsialpox.		1989	2722341
a study of nerves containing peptides in the pulmonary vasculature of healthy infants and children and of those with pulmonary hypertension.	nerves containing peptides that supply the human intrapulmonary vasculature were studied in 21 controls aged one month to 24 years and in 13 patients with pulmonary hypertension aged 11 days to eight years. an indirect immunofluorescence technique was used to study the distribution and relative density of nerve fibres containing the general neuronal marker, protein gene product 9.5; tyrosine hydroxylase; synaptophysin; neuropeptide tyrosine; vasoactive intestinal polypeptide; substance p, somato ...	1989	2686736
rickettsioses of the spotted fever group around the world.	spotted fever group rickettsioses comprise rocky mountain spotted fever (rickettsia rickettsii), boutonneuse fever (r. conorii), north asian tick typhus (r. sibirica), queensland tick typhus (r. australis), rickettsialpox (r. akari), and oriental spotted fever (r. japonica). ticks or mites serve as the vector and reservoir hosts of the rickettsiae. these obligate intracellular bacteria invade vascular endothelial cells, which are damaged directly, causing increased vascular permeability. the ras ...	1989	2677080
prevention of salmonella typhimurium colonization of broilers with d-mannose.	broiler chickens can be contaminated by salmonella typhimurium, which is a food safety concern. it has been previously shown that d-mannose blocks s. typhimurium adherence to chicken intestine in vitro. one-day-old broiler chickens were fed normal drinking water or drinking water supplemented with 2.5% mannose for 10 days. on day 3, both groups were challenged orally with 1 x 10(8) s. typhimurium [st-10 (animal diagnostics laboratory, ames, ia)] resistant to nal and nov (sigma, st. louis, mo). o ...	1989	2685797
cloning and nucleotide sequence of a cdna encoding the antifungal-protein of aspergillus giganteus and preliminary characterization of the native gene.		1990	2374718
species-specific monoclonal antibodies to rickettsia japonica, a newly identified spotted fever group rickettsia.	a total of 192 hybridomas were developed from mice immunized with rickettsia japonica, a newly identified spotted fever group rickettsia pathogenic for humans. of these hybridomas, 101 were species specific, 37 were spotted fever group reactive, and the other 54 were also reactive with one or more of the other pathogenic species of spotted fever group rickettsiae, rickettsia akari, rickettsia australis, rickettsia conorii, rickettsia rickettsii, and rickettsia sibrica. seven of the species-speci ...	1990	1696280
a primary demyelinating disorder of young cattle.	the clinical signs and neuropathological changes are described in six limousin x calves that, at about one month after birth, showed signs of blindness, nystagmus, rotation of the eyes, opisthotonos, hyperprotraction of the forelegs and, in one case, apparent seizures. pathologically there was necrosis of the optic chiasma and focal areas of myelin sheath vacuolation or demyelination in certain areas of the brain, especially in the cerebellar peduncles. in one animal, kept alive for 7 months, th ...	1991	1800911
atypical papulovesicular rash due to infection with rickettsia conorii.	we present an unusual case of rickettsia conorii infection that was associated with cutaneous papulovesicular lesions on a patient who had returned from the bushveld of south africa. the lesions were diffusely scattered across the trunk, extremities, and both palms. several recent reports have documented similar papulovesicular or pustulovesicular rashes that occurred on travelers returning from southern africa. these rashes resemble the lesions of rickettsialpox. evidence suggests that these at ...	1992	1420671
proteinic and genomic identification of spotted fever group rickettsiae isolated in the former ussr.	sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page), restriction fragment length polymorphism of polymerase chain reaction-amplified genes (rflp-pcr), and pulsed-field gel electrophoresis (pfge) were used to identify 25 isolates of spotted fever group rickettsia collected in the former ussr. six rickettsia akari isolates which were identical to the mk reference strain from the american type culture collection were found. also, 14 isolates were found to be rickettsia sibirica and ...	1993	7902843
dermatologic manifestations of arthropod-borne diseases.	the arthropod-borne rickettsial, borrelial, and bacterial diseases of north america are a diverse group of disorders that produce a wide variety of cutaneous abnormalities. these dermatologic abnormalities are often valuable clinical clues that may reveal or suggest the correct diagnosis to the astute clinician. we review the usual and unusual dermatologic manifestations of rocky mountain spotted fever, murine and sylvatic typhus, rickettsialpox, ehrlichiosis, lyme disease, tick-borne relapsing ...	1994	7814841
rickettsialpox in a new york city hospital, 1980 to 1989.	rickettsialpox is caused by rickettsia akari, which is transmitted from rodents to humans by bloodsucking mites. the initial skin lesion forms an eschar and is followed by the development of fever, malaise, myalgia, and 5 to 40 maculopapules and papulovesicles. the disease, which responds to tetracycline, can be mistaken for chickenpox. the diagnosis has been based on an increase in serum antibody titers against r. akari over a period of three to eight weeks. we discuss a more rapid technique th ...	1994	7969341
isolation, cultivation, and partial characterization of the elb agent associated with cat fleas.	elb rickettsiae from cat flea homogenates were recovered in tissue culture cells following sequential passage through laboratory rats and the yolk sacs of embryonated chicken eggs. seven days after inoculation of elb from the infected yolk sacs, vero cells and l929 cells were observed to contain intracellular bacteria as demonstrated by diff quik and indirect immunofluorescence assay staining. the rickettsial and elb identity of the cultured agent was confirmed by pcr detection of the 16s rrna a ...	1995	7591142
genomic study of rickettsia akari by pulsed-field gel electrophoresis.	pulsed-field gel electrophoresis of smai-, eagi-, and bsshii-digested dna was used to perform restriction fragment length polymorphism analysis of rickettsia akari strains isolated from humans, rodents, and mites in the united states and ukraine. although some differences in biological and serological characteristics were present between strains, the genomic studies demonstrated a high degree of intraspecies homogeneity of r. akari isolates. our results confirm the value of pulsed-field gel elec ...	1995	8576365
isolation of rickettsia akari from a patient in a region where mediterranean spotted fever is endemic.	rickettsia akari was isolated from blood collected from a patient in croatia in 1991. we believe this is the first human isolate of r. akari to be reported in more than 40 years and the first ever from southern europe. the croatian isolate was antigenically and genetically indistinguishable from the prototype american strain and a ukrainian strain. in all probability, rickettsialpox would be diagnosed more frequently and over a wider geographic area if physicians gave greater consideration to th ...	1996	8838175
rickettsialpox.		1996	8727130
genetic variation in australian spotted fever group rickettsiae.	rickettsiae were isolated by cell culture of buffy coat blood from six patients with spotted fever from southeastern australia and flinders island in bass strait. the isolates were genetically compared with two previous rickettsia australis patient isolates. the genus-specific 17-kda genes from the isolates were compared after dna amplification and restriction fragment analysis of the amplified dna. this comparison revealed that mainland rickettsial isolates from southeastern australia were iden ...	1996	8735110
medical microbiology	rickettsiae are small, gram-negative bacilli that have evolved in such close association with arthropod hosts that they are adapted to survive within the host cells. they represent a rather diverse collection of bacteria, and therefore listing characteristics that apply to the entire group is difficult. the common threads that hold the rickettsiae into a group are their epidemiology, their obligate intracellular life ...	1996	21413251
in vitro susceptibilities of bartonella henselae, b. quintana, b. elizabethae, rickettsia rickettsii, r. conorii, r. akari, and r. prowazekii to macrolide antibiotics as determined by immunofluorescent-antibody analysis of infected vero cell monolayers.	the in vitro susceptibilities of bartonella (rochalimaea) henselae, b. quintana, b. elizabethae, rickettsia akari, r. conorii, r. prowazekii, and r. rickettsii to different concentrations of azithromycin, clarithromycin, dirithromycin, erythromycin, and roxithromycin in vero cell cultures were evaluated. bartonella and rickettsia spp. were allowed to initiate infection of the antibiotic-free vero cell monolayers, which were maintained in 16-chamber microscope slides in the absence of antibiotics ...	1997	9055996
rickettsialpox-like illness in a traveler.	a patient presented after a trip to south africa with a febrile illness and rash that was consistent with either rickettsialpox or mild boutonneuse fever. the clinical, laboratory, and geographic overlap of these diseases makes differentiation difficult in certain situations. several different rickettsial infections may cause an eschar and a rash that may be papulovesicular. from a clinical perspective, distinguishing these diseases is not critically important as long as therapy with tetracyclin ...	1997	9290302
rickettsialpox.	rickettsialpox is a member of the spotted-fever group of the rickettsioses and results from an infection with rickettsia akari. this microbe is transmitted by the bite of the house-mouse mite liponyssoides sanguineus. patents experience fevers, sweats, headaches, and a vesicular eruption over the trunk and extremities. the palms and soles are spared. an eschar results at the spot of the mite bite. tetracycline is the treatment of choice.	1997	9098640
citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae.	using pcr and an automated laser fluorescent dna sequencer, we amplified and sequenced a 1,234-bp fragment of the citrate synthase-encoding gene (glta) of 28 bacteria belonging to the genus rickettsia. comparative sequence analysis showed that most of the spotted fever group (sfg) rickettsiae belonged to one of two subgroups. the first subgroup included rickettsia massiliae, strain bar 29, rickettsia rhipicephali, "rickettsia aeschlimanni," and rickettsia montana, which have been isolated only f ...	1997	9103608
taxonomic relationships among spotted fever group rickettsiae as revealed by antigenic analysis with monoclonal antibodies.	the spotted fever group (sfg) is made up of more than 20 different rickettsial species and strains. study of the taxonomic relationships among the group has been attempted by phenotypic, genotypic, and phylogenetic analyses. in this study, we determined taxonomic relationships among the sfg rickettsiae by comparative analysis of immunogenic epitopes reactive against a panel of monoclonal antibodies. a total of 98 monoclonal antibodies, which were directed against epitopes on the major immunodomi ...	1998	9542904
[rickettsialpox].		1999	10201193
monoclonal antibody-based immunohistochemical diagnosis of rickettsialpox: the macrophage is the principal target.	cutaneous biopsies of five eschars and two rash lesions from five patients from new york city with documented rickettsialpox were examined by immunohistochemical methods with a monoclonal antibody directed against spotted fever group rickettsial lipopolysaccharide for the presence and cellular location of rickettsia akari rickettsiae were identified in all of the five patients, with good concordance of results for the same biopsy tissues with previously reported results by the direct immunofluor ...	1999	10349992
serologic evidence of rickettsialpox (rickettsia akari) infection among intravenous drug users in inner-city baltimore, maryland.	we tested single serum samples from 631 intravenous (i.v.) drug users from inner-city baltimore, maryland for serologic evidence of exposure to spotted fever group rickettsiae. a total of 102 (16%) individuals had titers > or = 64 to rickettsia rickettsii by an indirect immunofluorescence assay. confirmation that infection was caused by r. akari was obtained by cross-adsorption studies on a subset of serum samples that consistently resulted in higher titers to r. akari than to r. rickettsii. cur ...	1999	10403316
molecular phylogeny and rearrangement of rrna genes in rickettsia species.	it has previously been observed that rickettsia prowazekii has an unusual arrangement of the rrna genes. in this species, the three rrna genes, 16s (rrs), 23s (rrl), and 5s (rrf), are not linked in the typical arrangements for bacteria. rather, the 16s rrna gene has been separated from the 23s and 5s rrna gene cluster, and the 23s rrna gene is preceded by a gene which codes for methionyl-trnaf(met) formyltransferase (fmt). in this study, we screened the genus rickettsia for the fmt-rrl motif in ...	1999	10406115
in vitro susceptibilities of rickettsia and bartonella spp. to 14-hydroxy-clarithromycin as determined by immunofluorescent antibody analysis of infected vero cell monolayers.	the in vitro susceptibilities of rickettsia akari, rickettsia conorii, rickettsia prowazekii, rickettsia rickettsii, bartonella elizabethae, bartonella henselae and bartonella quintana to different concentrations of clarithromycin, 14-hydroxy-clarithromycin (the primary metabolite of clarithromycin) and tetracycline in vero cell cultures, were determined by enumeration of immunofluorescently-stained bacilli. the extent of antibiotic-induced inhibition of foci was recorded for each dilution of an ...	2000	10702548
phylogeny of rickettsia spp. inferred by comparing sequences of 'gene d', which encodes an intracytoplasmic protein.	'gene d' is the ps120-protein-encoding gene, first described in rickettsia conorii and rickettsia japonica. sequence analysis of a 3030 bp fragment of 'gene d' in 24 representatives of the genus rickettsia was carried out to complete phylogenetic analyses previously inferred by comparison of gene sequences encoding citrate synthase, 17 kda antigen and rompa and rompb. the phylogenetic relationships between rickettsiae were inferred from the comparison of both the gene and the derived protein seq ...	2001	11491333
serologic evidence of rickettsia akari infection among dogs in a metropolitan city.	to determine whether dogs in new york, ny are naturally infected with rickettsia akari, the causative agent of rickettsialpox in humans.	2001	11394829
evidence of rodent-associated bartonella and rickettsia infections among intravenous drug users from central and east harlem, new york city.	we tested serum samples collected in 1997 and 1998 from a cohort of 204 injection drug users (idus) recruited from central and east harlem, new york city, new york, for antibodies reactive with seven rickettsial or bartonella spp. antigens. rodent-associated bartonella elizabethae and rickettsia akari were the primary etiologic agents of interest. the testing panel also included bartonella henselae, bartonella quintana, rickettsia prowazekii, rickettsia rickettsii, and rickettsia typhi. the high ...	2001	11791987
urban zoonoses caused by bartonella, coxiella, ehrlichia, and rickettsia species.	the last half of the 20th century witnessed an increase in the occurrence and recognition of urban zoonoses caused by members of the genera bartonella, coxiella, ehrlichia, and rickettsia, all traditionally considered to be members of the family rickettsiaceae. in recent years, new human pathogens (bartonella elizabethae, bartonella henselae, and rickettsia felis) have been recognized in urban environments. other newly recognized pathogens (ehrlichia chaffeensis and ehrlichia phagocytophila in t ...	2001	12653141
rickettsia-macrophage interactions: host cell responses to rickettsia akari and rickettsia typhi.	the existence of intracellular rickettsiae requires entry, survival, and replication in the eukaryotic host cells and exit to initiate new infection. while endothelial cells are the preferred target cells for most pathogenic rickettsiae, infection of monocytes/macrophages may also contribute to the establishment of rickettsial infection and resulting pathogenesis. we initiated studies to characterize macrophage-rickettsia akari and -rickettsia typhi interactions and to determine how rickettsiae ...	2002	11953398
phylogenetic analysis of spotted fever group rickettsiae isolated from ticks in japan.	eight spotted fever group (sfg) rickettsiae isolated from ticks in japan were classified by phylogenetic analysis based on the nucleotide sequences of both the citrate synthase-encoding gene (glta) and 190-kda antigen-encoding gene (rompa). in the phylogenetic tree of glta, strains dt-1 and fla-1 isolated from the dermacentor taiwanensis and haemaphysalis frava ticks, respectively, were placed as rickettsia japonica, and strains io-1, io-2, io-25, im-1 and ip-2 from genus ixodes ticks were place ...	2002	12061626
rickettsialpox in north carolina: a case report.	we report a case of rickettsialpox from north carolina confirmed by serologic testing. to our knowledge, this case is the first to be reported from this region of the united states. including rickettsialpox in the evaluation of patients with eschars or vesicular rashes is likely to extend the recognized geographic distribution of rickettsia akari, the etiologic agent of this disease.	2002	12095443
away with leniency toward gastric pseudolymphoma.		2002	2730333
a simple method for measuring the frequency response of an electromagnetic flowmeter.		2002	127898
[transketolase activity as a parameter for the vitamin b1 provision in some dermatoses (herpes zoster, psoriasis, drug eruptions, excema, and urticaria) (author's transl)].		2003	153861
expression of inducible angiosperm promoters in a gymnosperm, picea glauca (white spruce).	electrical discharge particle acceleration was used to test the transient expression of numerous inducible angiosperm promoters in a gymnosperm picea glauca (white spruce). promoter expression was assayed in three different tissues capable of in vitro regeneration, zygotic embryos, seedlings and embryogenic callus. the promoters tested include the light-inducible arabidopsis and soybean ribulose-1,5-bisphosphate small subunit promoters and a maize phosphoenolpyruvate carboxylase promoter; a soyb ...	2003	1868222
rickettsialpox in a patient with hiv infection.	we describe the first case of rickettsialpox in a patient infected with hiv. immunohistochemical staining of biopsied lesions showed a relatively large number of rickettsiae within the papulovesicular rash. rickettsialpox is easily treated and may resemble more serious cutaneous eruptions in patients infected with hiv. this diagnosis should be considered in immunocompromised city-dwellers, with fever and a papulovesicular rash.	2003	12582406
rickettsialpox in new york city: a persistent urban zoonosis.	rickettsialpox, a spotted fever rickettsiosis, was first identified in new york city (nyc) in 1946. during the next five years, approximately 540 additional cases were identified in nyc. however, during the subsequent five decades, rickettsialpox received relatively little attention from clinicians and public health professionals, and reporting of the disease diminished markedly. during february 2001 through august 2002, 34 cases of rickettsialpox in nyc were confirmed at cdc from cutaneous biop ...	2003	12860597
increased detection of rickettsialpox in a new york city hospital following the anthrax outbreak of 2001: use of immunohistochemistry for the rapid confirmation of cases in an era of bioterrorism.	rickettsialpox is a self-limited febrile illness with skin lesions that may be mistaken for signs of potentially more serious diseases, such as cutaneous anthrax or chickenpox. the cluster of cutaneous anthrax cases from bioterrorism in october 2001 likely heightened awareness of and concern for cutaneous eschars.	2003	14676069
rickettsialpox in turkey.		2003	14725263
[contribution of the section medical pedagogy to the improvement of quality and effectiveness of health care].		2004	425577
provision of a lingual biting platform in a severe class iii malocclusion: a case report.		2004	321730
rickettsialpox: report of three cases and a review.	rickettsialpox is a rare mite-borne rickettsiosis that is encountered in urban populations in the eastern united states and throughout the world. it is characterized clinically by an eschar, fever, and a papulovesicular eruption. both of these cutaneous manifestations may be mimicked by infectious diseases that have been designated as bioterrorist agents by the united states centers for diseases control and prevention: the former by anthrax, and the latter by smallpox. it is thus important for c ...	2004	15577753
[the physician in the future].		2004	440600
detection of rickettsial dna in ixodid ticks recovered from dogs and cats in japan.	dna from ticks recovered from 1137 dogs and 133 cats from all over japan were examined for rickettsia infection by citrate synthase gene (glta)-based pcr and partial nucleotide sequencing. a total of 91 dog tick samples and 18 cat tick samples showed a single band of the appropriate size in the nested pcr. sequence analysis was successfully performed on 102 samples. dna of rickettsia japonica or closely related rickettsia spp. strains were detected from 38 ticks in 16 prefectures mainly in weste ...	2005	16397379
cardiac and great vessel trauma: assessment, pathophysiology, and intervention.		2005	3320442
rickettsial infections around the world, part 2: rickettsialpox, the typhus group, and bioterrorism.		2005	16392013
[rickettsialpox: report of two cases imported from south africa].	rickettsialpox is a rickettsiosis characterized clinically by an escar, fever and papulovescicular eruption. the author reports two cases imported from south africa.	2005	16498729
spotted fever group and typhus group rickettsioses in humans, south korea.	the presence of the nucleic acid of the spotted fever group (spg) and typhus group (tg) rickettsiae was investigated in 200 serum specimens seropositive for sfg rickettsiae by multiplex-nested polymerase chain reaction with primers derived from the rickettsial outer membrane protein b gene. the dna of sfg, tg, or both rickettsiae was amplified in the 24 serum specimens, and sequence analysis showed rickettsia conorii, r. japonica, and r. felis in the specimens. r. conorii and r. typhi were found ...	2005	15752441
transcription of the rickettsia felis ompa gene in naturally infected fleas.	rickettsia felis is maintained transovarially in ctenocephalides felis fleas in a widespread geographic distribution and is transmitted to humans and animals, including opossums. this rickettsia is phylogenetically a member of the spotted fever group, most closely related to rickettsia akari and r. australis. an unusual feature of this rickettsia is that the gene for the outer membrane protein a (ompa) is interrupted by stop codons. to determine if this putatively dying gene is expressed, mrna w ...	2005	16222005
a highly sensitive and specific real-time pcr assay for the detection of spotted fever and typhus group rickettsiae.	a highly specific real-time polymerase chain reaction (pcr) assay was developed to detect spotted fever and typhus group rickettsiae using the citrate synthase gene as the target. the assay amplified rickettsial members of the spotted fever and typhus group including rickettsia akari, r. australis, r. conorii, r. honei, "r. marmionii," r. sibirica, r. rickettsii, r. typhi, and r. prowazekii. the ancestral group rickettsia, r. bellii, did not produce a positive reaction, nor did other members of ...	2005	16354816
arthropod-borne diseases in homeless.	homeless people are particularly exposed to ectoparasite. the living conditions and the crowded shelters provide ideal conditions for the spread of lice, fleas, ticks, and mites. body lice have long been recognized as human parasites and although typically prevalent in rural communities in upland areas of countries close to the equator, it is now increasingly encountered in developed countries especially in homeless people or inner city economically deprived population. fleas are widespread but ...	2006	17114713
nutrition and head start.		2006	1458961
current knowledge of rickettsial diseases in italy.	rickettsial diseases continue to be the cause of serious health problems in italy. from 1998 to 2002, 4,604 clinical cases were reported, with 33 deaths in the period from 1998 to 2001. almost all the cases reported in italy are cases of mediterranean spotted fever (msf). other rickettsioses that have been historically documented are murine typhus and epidemic typhus. since 1950, only sporadic cases of murine typhus have been reported, and italy currently appears to be free of epidemic typhus. a ...	2006	17114696
supporting collaboration through a nursing informatics curriculum stage ii.	collaboration is at the center of the process used to design, implement and evaluate an integrated informatics curriculum in a baccalaureate nursing program. this paper describes the second stage of a process to design the informatics nursing courses. the challenges to foster faculty collaborative relationships as well as to enhance the course content of all nursing informatics curriculum. a number of strategies were used to develop the collaborative efforts between the faculty and nursing staff ...	2006	1482910
child abuse: does prosecution serve any useful purpose?		2006	1635513
[torsion of the colonic epiploic appendages].	operations were carried out on 21 patients with torsion of epiploic appendages of the colon (sigmoid 19, ascending 1, hepatic flexure 1). this pathologic condition has no specific manifestations and occurs under the mask of other emergencies. the suggested symptom of "pain displacement" in combination with other signs allowed the correct diagnosis to be established before the operation in two thirds of patients. patients with torsion of epiploic appendages must be subjected to an emergency opera ...	2006	1388218
rickettsial agents from parasitic dermanyssoidea (acari: mesostigmata).	mites are often overlooked as vectors of pathogens, but have been shown to harbor and transmit rickettsial agents such as rickettsia akari and orientia tsutsugamushi. we screened dna extracts from 27 mites representing 25 species of dermanyssoids for rickettsial agents such as anaplasma, bartonella, rickettsia, and wolbachia by pcr amplification and sequencing. dna from anaplasma spp., a novel bartonella sp., spiroplasma sp., wolbachia sp., and an unclassified rickettsiales were detected in mite ...	2006	16596351
[asthma and sports].		2006	3291047
isolation of rickettsia akari from eschars of patients with rickettsialpox.	rickettsialpox is a cosmopolitan, mite-borne, spotted fever rickettsiosis caused by rickettsia akari. the disease is characterized by a primary eschar, fever, and a papulovesicular rash. rickettsialpox was first identified in new york city in 1946 and the preponderance of recognized cases in the united states continues to originate from this large metropolitan center. the most recently isolated u.s. strain of r. akari was obtained more than a half century ago. we describe the culture and initial ...	2006	17038703
serologic evidence of a rickettsia akari-like infection among wild-caught rodents in orange county and humans in los angeles county, california.	we detected antibodies reactive with rickettsia akari, the etiologic agent of rickettsialpox in humans and in 83 of 359 (23%) rodents belonging to several species, collected in orange county, ca. reciprocal antibody titers >1:16 to r. akari were detected in native mice and rats (peromyscus maniculatus, p. eremicus, and neotoma fuscipes) and in old world mice and rats (mus musculus, rattus rattus, and r. norvegicus), representing the first time that antibodies reactive with this agent have been d ...	2007	18260508
[treatment of breastplate deformities: assessment using ct scanning and functional tests].	a study to evaluate both the pre- en postoperative functional and morphologic status of major anterior chest wall deformities. four of the eight patients suffered from a progressive reduction in physical capabilities. preoperative pulmonary function tests demonstrated restriction in pulmonary function. in the postoperative period there was progressive return to normal physical strength without objective improvement in pulmonary function. pre- and postoperative thoracometric study by ct scan allo ...	2007	1950309
long-term enteral feeding: a retrospective comparison of delivery via percutaneous endoscopic gastrostomy and nasoenteric tubes.	the use of percutaneous endoscopic gastrostomy (peg) tubes for enteral feeding is widespread, although their superiority to other feeding devices, such as nasoenteric tubes (net), has not been substantiated. we retrospectively compared clinical outcomes in patients who received enteral feeding via peg (n = 80) or net (n = 29) from 1984 to 1988. mean follow-up was 192 days in the peg group and 141 days in the net group. changes in nutritional and performance status were similar in both groups. as ...	2007	1951237
spotted fever rickettsioses in southern and eastern europe.	mediterranean spotted fever due to rickettsia conorii conorii was thought, for many years, to be the only tick-borne rickettsial disease prevalent in southern and eastern europe. however, in recent years, six more species or subspecies within the spotted fever group of the genus rickettsia have been described as emerging pathogens in this part of the world. tick-borne agents include rickettsia conorii israelensis, rickettsia conorii caspia, rickettsia aeschlimannii, rickettsia slovaca, rickettsi ...	2007	17266709
[measurement of orthodontic appliance force using prototype sensors].	in introductory remarks the most important biomechanical principles, which are relevant for the research, and conditions which must be satisfied presented in intraoral measuring of orthodontic forces were pointed out. first the aim of the research was defined, and then the investigation of mechanical properties of acrylics as a material for orthodontic appliances were carried out. the type of strain gauges, bonds and measuring system configurations, as well as measuring amplifiers and recording ...	2008	2635572
hepatitis in association with rickettsialpox.	rickettsialpox is an acute, self-limited, febrile illness caused by rickettsia akari and transmitted by liponyssoides sanguineus, a mite that infests the common house mouse, mus musculus. liver involvement in rickettsialpox has received little attention, although hepatitis has been reported in several other rickettsial infections. in this report, we describe two patients with rickettsialpox who had acute hepatitis that resolved completely. in the appropriate clinical setting, rickettsialpox shou ...	2008	18171106
[contribution of all-ussr (russian) center of rickettsioses and collaboration centre of who to the study of rickettsioses of tick-borne spotted fever group].	the manuscript presents the results of studies of rickettsioses of spotted fever group in the territories of ussr (russia) and chssr (slovakia). authors review data about isolation of strains of rickettsiae of spotted fever group, improvement of isolation techniques, diagnostics and diagnostic preparations.	2008	18756783
pretest expectancies and cognitive impairment in alcoholics.	alcoholics' neurological deficits have been attributed to cognitive impairment associated with brain dysfunction. because alcoholics perceive themselves as impaired in higher cognitive functions, we investigated the alternative hypothesis that their deficits are predicted by lowered expectancies for successful performance. ss were 48 male, middle-aged veterans administration inpatient alcoholics and 36 community controls. subjects completed a standard series of neuropsychological tests. before t ...	2008	2600240
quantitative margin analysis in the scanning electron microscope.	interface between restorative materials and tooth hard substances must be morphologically as perfect as possible to avoid plaque accumulation and subsequent secondary caries or pulpal diseases. therefore the marginal behavior of restorations is an important parameter to predict their longevity. morphologically, the quality of margins is characterized by different well defined criteria. using a replica technique it is possible to assess the complete marginal circumference of restorations in the s ...	2009	2740861
surgery and adjuvant chemotherapy for gastric cancer.	a review has been made of the results of surgical treatment of 8,000 cases of gastric cancer treated at the cancer institute hospital, tokyo, between 1946 and 1986. resectability was 89.6%, and operative mortality 1.9%. the five-year survival rate was 37.4% for all cases, 59.4% for patients with curative surgery, and 5.0% for those with non-curative surgery. the curative rate improved more than twofold over 41 years among the patients with curative gastrectomy. no one survived more than five yea ...	2009	2659483
elevation of factor vii activity and mass in young adults at risk of ischemic heart disease.	the northwick park heart study found that elevation of factor vii in middle-aged subjects was an independent risk factor for subsequent ischemic heart disease. the present study was designed to determine whether factor vii elevation is present at a younger age and whether zymogen or activated factor vii is responsible for this elevation. a group of 20 asymptomatic first degree relatives (mean age 34.9 years) of patients with premature ischemic heart disease were compared with 15 age-matched norm ...	2009	2794283
history of medicine in alaska. harriet crocker jackson schirmer, m.d.		2009	2662801
safety of chorionic villus sampling.		2009	2866381
a dog naturally infected with rickettsia akari in yucatan, méxico.	rickettsia akari is the causative agent of rickettsialpox, a primarily urban mite-borne rickettsiosis that is encountered in the united states and in a few countries around the world. its vector is the mite liponyssoides sanguineus, which is found on rats and mice, which serve as reservoirs for the disease. in this work we report a severe animal case of r. akari infection with two unusual features: r. akari was found in a dog, and its potential vector was a tick.	2009	19492943
human rickettsialpox, southeastern mexico.	the detection of rickettsia akari in 2 human patients increased the diversity of rickettsioses affecting the public health in the southeast of mexico. rickettsialpox should be considered in the differential diagnosis with other febrile illnesses for the correct diagnosis and accurate treatment of this potential threat to human health.	2009	19861070
wide dispersal and possible multiple origins of low-copy-number plasmids in rickettsia species associated with blood-feeding arthropods.	plasmids are mobile genetic elements of bacteria that can impart important adaptive traits, such as increased virulence or antibiotic resistance. we report the existence of plasmids in rickettsia (rickettsiales; rickettsiaceae) species, including rickettsia akari, "candidatus rickettsia amblyommii," r. bellii, r. rhipicephali, and reis, the rickettsial endosymbiont of ixodes scapularis. all of the rickettsiae were isolated from humans or north and south american ticks. r. parkeri isolates from b ...	2010	20097813
endemic mite-transmitted dermatoses and infectious diseases in the south.	mites are mostly ubiquitous, bothersome pests with few species of medical importance and, of these, most are scabies mites, trombiculid larval mites and animal and plant mites. all patients with scabies and their close household, institutional and sexual contacts should be informed that scabies is a highly transmissible ectoparasitic infestation and that several topical treatments and an effective oral treatment are readily available and highly effective at present. sexually active patients with ...	2010	20666166
involvement of tlr2 and tlr4 in cell responses to rickettsia akari.	a better understanding of the pathogenesis of rickettsial disease requires elucidation of mechanisms governing host defense during infection. tlrs are primary sensors of microbial pathogens that activate innate immune cells, as well as initiate and orchestrate adaptive immune responses. however, the role of tlrs in rickettsia recognition and cell activation remains poorly understood. in this study, we examined the involvement of tlr2 and tlr4 in recognition of rickettsia akari, a causative agent ...	2010	20616112
an in-vitro model for tumor immunotherapy with antibody heteroconjugates.		2010	2978374
spatial phase dependence and the role of motion detection in monocular and dichoptic forward masking.	contrast thresholds for briefly flashed gratings were measured by the quest procedure, under conditions of forward masking by gratings of the same spatial frequency (usually 1 c/deg). low-contrast masks reduced threshold at short onset asynchronies (0 to 50 msec), while higher contrasts raised threshold over a broader temporal range (0 to 100-140 msec). both effects depended on the spatial phase relation, but in different ways. threshold reduction at 0- +/- 90 deg phases probably arises from spa ...	2011	3253991
spatial phase dependence and the role of motion detection in monocular and dichoptic forward masking.	contrast thresholds for briefly flashed gratings were measured by the quest procedure, under conditions of forward masking by gratings of the same spatial frequency (usually 1 c/deg). low-contrast masks reduced threshold at short onset asynchronies (0 to 50 msec), while higher contrasts raised threshold over a broader temporal range (0 to 100-140 msec). both effects depended on the spatial phase relation, but in different ways. threshold reduction at 0- +/- 90 deg phases probably arises from spa ...	2011	3253991