Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| isolation of rickettsia rickettsi in primary bone marrow cell and circulating monocyte cultures derived from experimentally infected guinea pigs. | rickettsia rickettsi was isolated and propagated in primary cell cultures derived from experimentally infected guinea pigs. organisms were recognized as early as 3 days after cultures were initiated. | 1973 | 4197749 |
| metabolism of richettsia tsutsugamushi and rickettsia rickettsi in irradiated host cells. | the metabolism of rickettsia tsutsugamushi (gilliam strain) multiplying in irradiated l cells was investigated by methods involving the use of (14)c-labeled substrates and cycloheximide, an inhibitor of eukaryotic metabolism. cycloheximide-resistant amino acid and adenine incorporations were appreciably higher in infected than in uninfected cultures during the period from 3 to 5 or 6 days postinoculation. the metabolism of r. rickettsi was similarly studied in primary duck embryo cells, which ar ... | 1973 | 4198104 |
| rocky mountain spotted fever: a comparative study of the active immunity induced by inactivated and viable pathogenic rickettsia rickettsii. | 1973 | 4199563 | |
| contrasting incidence of rocky mountain spotted fever in ticks infesting wild birds in eastern u.s. piedmont and coastal areas, with notes on the ecology of these ticks. | 1973 | 4202513 | |
| cytogenetic engineering in vivo: restoration of biologic complement activity to c5-deficient mice by intravenous inoculation of hybrid cells. | splenic macrophages were identified as at least one source of c5 elaboration in normal mice. hybrid cells were formed from splenic macrophages from c5-deficient mice and either kidney cells from mice with normal amounts of c5 or chicken erythrocytes. these hybrids elaborated c5 in vitro. c5-deficient mice inoculated with these hybrid cells developed, in their serum, antigenically active mouse c5, as well as both hemolytic and biologic complement activity. these studies demonstrate the feasibilit ... | 1973 | 4131744 |
| dna base composition of rickettsiae. | there is a small but distinct difference in dna base composition between the typhus and spotted fever groups of rickettsiae. the molar percentages of guanine plus cytosine for rickettsia prowazeki, r. typhi, and r. canada are approximately 30, for r. rickettsi, r. conori, and r. akari they are about 32.5. the percentage for trench fever rickettsia, rochalimaea quintana, is 38.6. | 1973 | 4633692 |
| changes in cell surface properties during the in vivo growth of moloney lymphoma. | 1973 | 4575651 | |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 26-1973. | 1973 | 4196462 | |
| summary of recent abstracts. vii. rickettsial diseases. | 1973 | 4207153 | |
| helium-cold induced hypothermia in the white rat. | 1973 | 4692003 | |
| chronic benign lymphocytic meningitis. | 1973 | 4699432 | |
| reactions of fluoride and carbonate ions during dissolution and mineralization of partially recalcified dentin. | 1973 | 4703038 | |
| [non-specific pharmacodynamic properties of chlorpromazine (cpz) in relationship to the characteristic specific action of the drug]. | 1973 | 4736261 | |
| a pool of naturally occurring rat liver ribosomal subunits capable of translating exogenous messenger rna. | 1973 | 4763323 | |
| genetic differences in the structure of the mouse testes. | 1973 | 4771359 | |
| sympathetic discharge rate in spontaneously hypertensive rats. | 1973 | 4542949 | |
| proceedings: central respiratory activity in the mature sheep foetus. | 1974 | 4818509 | |
| letter: 4-amino-4-deoxy-alpha, alpha-trehalose, a new metabolite of a streptomyces. | 1974 | 4826088 | |
| rickettsial infectious antibody complexes: detection by antiglobulin plaque reduction technique. | rickettsia rickettsii and r. australis formed infectious antibody complexes when reacted with homologous convalescent serum. the addition of antiglobulin to these complexes showed neutralization of plaques proportional to the concentration of rickettsial immune serum. | 1974 | 4207520 |
| the isolation of strains of rickettsiae of the spotted fever group in israel and their differentiation from other members of the group by immunofluorescence methods. | 1974 | 4208205 | |
| plaque assay of rickettsiae in a mammalian cell line. | clear-cut and repeatable plaque assays were obtained for three rickettsiae of the spotted fever group (rickettsia rickettsi, r. conori, and r. montana) in vero cells used in a manner similar to that for arboviruses. in addition, three typhus group agents (r. typhi, r. canada, r. prowazeki) induced plaques in these cells. in preliminary tests coxiella burneti (nine mile strain) failed to produce plaques. comparable results were obtained in plastic flasks and plastic culture trays incubated in amb ... | 1974 | 4208640 |
| origin and structure of the group-specific, complement-fixing antigen of rickettsia rickettsii. | rickettsia rickettsii was treated with ether and examined by negative-contrast electron microscopy. group-specific complement-fixing antigen was seen to be originating from the cell wall. the antigen was composed predominately of round particles 10 to 60 nm in diameter. intact r. rickettsii and antigen from ether-treated organisms were purified by density gradient centrifugation and analyzed by polyacrylamide gel electrophoresis. the whole rickettsial cell was composed of a minimum of 30 protein ... | 1974 | 4213992 |
| stereospecific irreversible inhibition of histidine ammonia-lyase by l-cysteine. | 1974 | 4214552 | |
| purification of rickettsia rickettsi by density-gradient zonal centrifugation. | 1974 | 4215550 | |
| use of frozen chick and duck embryo cells for plaque assays of arboviruses and rickettsiae. | 1974 | 4376554 | |
| studies on amino acid utilization in relation to virulence of macrophomina phaseoli causing disease of jute (corchorus capsularis l.). | 1974 | 4407383 | |
| inhibition of scopolamine-induced stimulation of y-maze activity by alpha-methyl-p-tyrosine and by lithium. | 1974 | 4418163 | |
| is intra-arterial 5-hydroxytryptamine a potent algogenic substance in the dog? | 1974 | 4435010 | |
| the difil test kit for detection of canine heartworm microfilariae. | 1974 | 4492851 | |
| susceptibility of the phix-like phages g4 and g14 to r-ecori endonuclease. | 1974 | 4608028 | |
| properties of uvre mutants of escherichia coli k12. i. effects of uv irradiation on dna metabolism. | 1974 | 4612354 | |
| viral subtypes and cross-protection in hepatitis b virus infections of chimpanzees. | 1974 | 4140852 | |
| effect of 16alpha-cyanopregnenolone on the hydroxylation of lithocholic acid by rat liver microsomes. | 1974 | 4149368 | |
| rickettsial plaques in mosquito cell monolayers. | 1974 | 4156160 | |
| zoonotic potential (rocky mountain spotted fever aed tularemia) in the tennessee valley region. ii. prevalence of rickettsia rickettsi and francisella tularensis in mammals and ticks from land between the lakes. | 1974 | 4204021 | |
| zoonotic potential (rocky mountain spotted fever and tularemia) in the tennessee valley region. i. ecologic studies of ticks infesting mammals in land between the lakes. | 1974 | 4204030 | |
| the manufacture of moulded supportive seating for the handicapped. | the wheelchair-bound population often have difficulty in obtaining a correct or comfortable posture in their chairs and sometimes develop pressure sores from long-duration sitting. this problem is being solved by manufacturing personalised, contoured seats which support the patient over the maximum area possible thereby reducing the pressure on the body and the incidence of pressure sores. a cast is obtained of the patient in a comfortable, medically correct posture and from this cast the seat i ... | 1975 | 126704 |
| [morphological and biochemical studies on the retinal blood vessels of streptozotocin diabetic rats (author's transl)]. | 1975 | 130794 | |
| sphingomyelinase of chicken erythrocyte membranes. | 1975 | 165774 | |
| size and charge heterogeneity of rat tissue ferritins. | ferritins purified from horse spleen and from rat liver, kidney, heart and hepatoma were analyzed by quantitative polyacrylamide gel electrophoresis. from the migration characteristics of these ferritins at several gel concentrations, ferguson plots were constructed and the molecular sizes and charges (apparent valences) together with their statistical variability were obtained by applying rodbard computer programs to the data. finally, ellipses were drawn describing the 95% confidence limits of ... | 1975 | 172145 |
| [calcium and magnesium concentrations of the renal cortex in the rat. comparison of 3 methods of tissular extraction of the principal cations]. | we describe three methods for extraction of main tissular cations : a) dry ashing method; b) wet ashing method with hno3; c) wet method on fresh tissue with hcio4. this study allows the determination of tissular concentrations of calcium, magnesium in renal cortex of the rat. our findings show : a loss of na, k cations probably by volatilization with dry ashing method ; inability for k determination when hcio4 method is used ; tissular concentrations are : 4,7 meq ca ; 21,6 meq mg per kg of wet ... | 1975 | 172839 |
| adaptation of skeletal muscle to endurance exercise. | skeletal muscle adapts to endurance excerise, such as long distance running, with an increase in the capacity for aerobic metabolism. this is reflected in an increased capacity of whole homogenates and of the mitochondrial fraction of muscle to oxidize pyruvate and long chain fatty acids. underlying this increase in the ability to obtain energy by respiration is an increase in the levels of a number of mitochondrial enzymes. these include the enzymes involved in fatty acid oxidation, the enzymes ... | 1975 | 173969 |
| malignant transformation-linked imbalance: decreased xanthine oxidase activity in hepatomas. | xanthine oxidase was decreased 2- to 10-fold in all examined rat hepatomas irrespective of the malignancy; growth rate and degrees of histological differentiation of the neoplasms. the affinity to substrate (km=6-8 mum) and the ph optimum (8.0) of the liver and hepatoma enzymes were the same. the reprogramming of gene expression, as manifested in the decreased activity of this key purine metabolizing enzyme, appears to be specific to neoplastic transformation. since glutamine prpp amidotransfera ... | 1975 | 179860 |
| immunological properties of rickettsia rickettsii purified by zonal centrifugation. | the properties of rickettsia rickettsii purified from infected chicken yolk sacs or mouse l cell cultures by sucrose density gradient centrifugation in a zonal rotor were examined in various ways. rickettsiae derived from both l cells and yolk sacs had similar compositions: about 12% nitrogen, 1.5% phosphorus, 5% carbohydrate, and 30% fatty acids. on a dry-weight basis, purified rickettsiae were at least 2,000 times as effective as a commercial spotted fever vaccine in protecting guinea pigs aga ... | 1975 | 806522 |
| rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the united states. | a rickettsia related to but distinct from the spotted fever agent, rickettsia rickettsii, has been detected in 167 (18.9%) of 884 rhipicephalus sanguineus taken off dogs in central and northern mississippi. the organisms could readily be isolated in male meadow voles (microtus pennsylvanicus), where it produced massive infections in the tissues of tunica vaginalis. it was practically nonpathogenic for male guinea pigs, although inoculation of these animals with infected tunica vaginalis of voles ... | 1975 | 806533 |
| preparation of rocky mountain spotted fever vaccine suitable for human immunization. | rocky mountain spotted fever vaccine was produced from rickettsiae grown in chicken embryo cells in roller bottle cultures. the rickettsiae were concentrated and purified by passage through a sucrose gradient and inactivated with formalin. this vaccine satisfactorily passed preinactivation and final container testing and is believed to be superior to the presently available yolk sac vaccine. | 1975 | 809483 |
| comparison of three rocky mountain spotted fever vaccines. | growth of rocky mountain spotted fever (rmsf) rickettsiae in duck embryo cell (dec) cultures and chicken embryo cell (cec) cultures was evaluated. experimental lots of duck embryo cell- and chicken embryo cell-grown rocky mountain spotted fever vaccines and a commercial lot of yolk sac-grown vaccine were compared for protective efficacy in rhesus monkeys. incidence and magnitude of antibody response, febrile response, and rickettsemia, as well as incidence of fatalities, suggested that both cell ... | 1975 | 810494 |
| a review of rocky mountain spotted fever (tick-borne typhus), its agent, and its tick vectors in the united states. | 1975 | 810584 | |
| rocky mountain spotted fever (tick-borne typhus) in south carolina: an educational program and tick/rickettsial survey in 1973 and 1974. | because the incidence of spotted fever is increasing in south carolina, campaigns were carried out in 1973 and 1974 to provide the public and medical practitioners, through pamphlets and news media, with information about spotted fever and the ticks which transmit the causative agent, rickettsia rickettsii. people were also invited to save and submit live ticks removed from vegetation, animals and humans, for examination by the hemolymph test. a total of 1,186 ticks consisting of 987 dermacentor ... | 1975 | 811127 |
| indirect hemagglutination test for human antibody to typhus and spotted fever group rickettsiae. | an indirect hemagglutination (iha) test is described that uses glutaraldehyde-stabilized erythrocytes treated with a rickettsial erythrocyte-sensitizing substance obtained from rickettsia typhi or rickettsia rickettsii. the serological reagent was stable for at least 3 months at room temperature and 6 months at 4 c. it exhibited group specificity and no group cross-reactivity. at a minimum dilution of 1:40, acute and early convalescent epidemic and murine typhus antisera showed 86% positive reac ... | 1975 | 811685 |
| evaluation ofprimary blood monocyte and bone marrow cell culture for the isolation of rickettsia rickettsii. | rickettsia rickettsii was isolated from experimentally infected guinea pigs by culture of blood monocytes and bone marrow cells, and from experimentally infected rhesus monkeys by blood monocyte culture. rickettsiae were identified in monocyte-macrophage monolayers stained by giménez or flourescent antibody techniques. a total of 78 culture attempts were made from 20 guinea pigs and 16 monkeys. the success of isolation of r. rickettsii in culture was positively correlated with the numbers of ric ... | 1975 | 812828 |
| comparative morphology of genital cones of genus ancylostoma dubini, 1843. | male worms of ancylostoma braziliense, a. ceylanicum, a. kusimaense, a. malayanum, a. duodenale, a. caninum, a. tubaeforme, agriostomum vryburgi and cyclodontostomum purvisi have the external appendages beside the anogenital aperture. these anogenital structures are morphologically similar and are assumed to be homologous among the species with three pairs of teeth or more. in hookworms with two pairs of teeth, the anogenital structures are complex. anogenital features can be used as a taxonomic ... | 1975 | 1166351 |
| vectors and vertical transmission: an epidemiologic perspective. | 1975 | 829470 | |
| mechanisms of transovarial infection of spotted fever rickettsiae in ticks. | 1975 | 829476 | |
| the feds are here--almost. | 1975 | 274203 | |
| erythropoietin dependent erythropoiesis during the erythroblastic phase of juvenile chronic granulocytic leukaemia. | a child aged 3 1/2 years with typical juvenile chronic granulocytic leukaemia whose course terminated in an erythroblastic phase is described. both in-vivo transfusion studies and in-vitro bone marrow culture studies indicate that red cell production remains erythropoietin dependent in this situation. the relationship of erythropoietin to the reversion to fetal haematopoiesis which characterizes juvenile chronic granulocytic leukaemia is discussed. | 1975 | 274145 |
| is partnership with parents really possible? | 1975 | 415200 | |
| an analysis of three mixed dentition analyses. | the accuracy of prediction of three mixed dentition analyses was compared. hixon and oldfather's method was found to be the most accurate. a simplified version of the analysis obviates referral to a table, allowing assessment of the size of the unerupted teeth prior to eruption of the lateral incisor. | 1976 | 274455 |
| significance of the cell cycle in commitment of murine erythroleukemia cells to erythroid differentiation. | the relationship between differentiation of murine erythroleukemia cells (mel) induced by dmso and the cell division cycle has been analyzed. we demonstrate that incubation in the presence of dmso increases the length of the g1 phase of the cell cycle. a method of synchronization of mel cells by unit gravity sedimentation has been developed and characterized. using this method, a series of synchronized cell populations covering the entire cell division cycle can be generated simultaneously. cell ... | 1976 | 274446 |
| genetic markers for schizotaxia. | evidence is presented for the occurrence of a locus for schizotaxia on the short arm of chromosome 6. this derives from study of 63 informative members of seven pedigrees in which the proband and a parent (or a sib of parent) suffered with schizophrenia and other kin were either normal or fell within a spectrum of conditions related to schizophrenia. for linkage of hla and schizotaxia a lod score, 2.57, at recombination frequency 0.15 is reported, which gives p = 0.008. this is in contrast to da ... | 1976 | 420900 |
| adsorption of bacterionema maturchotii to uncoated and coated hydroxyapatite. | 1976 | 274226 | |
| interaction between coxiella burnetii and guinea pig peritoneal macrophages. | the phagocytosis and subsequent degradation of phase i and ii coxiella burnetii by macrophages obtained from immune and nonimmune guinea pigs were compared. phase i rickettsiae were more resistant to phagocytosis than were phase ii organisms. there was no significant difference in the percentage of phagocytosis of either phase of rickettsiae by macrophages from immune or nonimmune animals. after ingestion, phase i and ii organisms pretreated with normal serum multiplied and destroyed normal macr ... | 1976 | 971955 |
| high resolution polyacrylamide gradient gel electrophoresis. | a method was developed for high resolution electrophoresis of proteins in linear gradient (3 to 30%) polyacrylamide gel rods in a neutral phosphate buffer containing 0.1% sodium dodecyl sulfate. well-defined protein zones were observed and improved resolution was attained especially for low molecular weight proteins in preparations containing a variety of polypeptides, e.g. viruses that are often separated by continuous gel methods. electropherograms of continuous (8%) and gradient (3 to 30%) ge ... | 1976 | 1005359 |
| dynamic cisternography in normal dogs and in human beings. | cisternography and ventriculography were performed in five normal anesthetized dogs to study the dynamics of tracer dispersal. indium 111-diethylenetriaminepentaacetic acid was injected into lateral ventricles, cisterna magna, thoracic subarachnoid space, and lumbar sac. the patterns of dispersal from each injection site support a nonflow dispersal mechanism with a tendency toward ultimate equilibrium distribution throughout the cerebrospinal fluid. quantitative data in humans complement observa ... | 1976 | 1082560 |
| early diagnosis of rocky mountain spotted fever. use of primary monocyte culture technique. | diagnosis of rocky mountain spotted fever was made as early as the fourth day of febrile illness in rhesus monkeys (macaca mulatta), with a monocyte culture technique that is easily amenable to use in humans. rickettsia rickettsii were identified by direct immunofluorescent and gimenez staining of cultures of circulating monocytes from four experimentally infected monkeys, even in the presence of a mild or inapparent disease in three. levels of rickettsemia were estimated by the plaque-assay tec ... | 1976 | 814256 |
| rocky mountain spotted fever in mississippi: survey for spotted fever antibodies in dogs and for spotted fever group reckettsiae in dog ticks. | during epidemiologic studies of rocky mountain spotted fever in mississippi in 1973, dogs were surveyed for antibodies tp spotted fever group antigens and for tick parasites infected with rickettsiae of the spotted fever group. fifty-three (46%) of 116 serum samples had complement-fixing antibody titers greater than or equal to 1:8 as compared to only one (5%) of 21 samples from a group of dogs obtained from metropolitan chicage. fifty-two per cent of the dogs tested from mississippi had microag ... | 1976 | 814809 |
| microimmunofluorescence test for the serological study of rocky mountain spotted fever and typhus. | a microimmunofluorescence test was used to study antibody responses to various spotted fever group and typhus group rickettsiae during rocky mountain spotted fever (rmsf) and epidemic typhus (et). patients with rmsf reacted most strongly to rickettsia rickettsii; those with et reacted predominantly to r. prowazekii. the degree of cross-reaction to other rickettsial strains varied from patient to patient, but a particular pattern of cross-reaction was consistently observed in serial sera from the ... | 1976 | 815267 |
| alterations in plasma copper, zinc, amino acids, and seromucoid during rocky moutain spotted fever in guinea pigs. | guinea pigs inoculated with virulent rickettsia rickettsii responded with a significant increase in plasma copper concentration within 1 day, preceding fever and detectable rickettsemia by 2 and 4 days, respectively. a decrease in serum zinc concentration coinciding with peak rickettsemia was detectable on day 5. evidence of altered host nitrogen metabolism during this illness included a doubling of plasma seromucoid concentration and a significant rise in the plasma phenylalanine/tyrosine ratio ... | 1976 | 817295 |
| antibody response to rocky mountain spotted fever. | various techniques were compared to determine the most sensitive method for detection of rocky mountain spotted fever antibody. a radiometabolic technique for detection of rocky mountain spotted fever antibody is also described. in infected monkeys, the fluorescent antibody technique yielded the earliest evidence of seroconversion; with some monkeys the microagglutination procedure was equally effective. the fluorescent antibody and microagglutination measurements showed higher titers than those ... | 1976 | 819455 |
| pathology of experimental rocky mountain spotted fever in rhesus monkeys. | rhesus monkeys were inoculated intravenously or intraperitoneally with various numbers of rickettsia rickettsii. monkeys that were given more than 10(4) organisms intravenously died on days 3-6 after inoculation, whereas those given less than 10(3) intravenously or more than 10(4) intraperitoneally died on day 7 or later. there was no significant difference in incidence of lesions between the early- and late-death groups. vasculitis and thrombosis occurred most frequently in the nares, pinna of ... | 1976 | 820052 |
| changes in blood serum constituents and hematologic values in macaca mulatta with rocky mountain spotted fever. | forty-seven male macaca mulatta, 3 to 4 kg weight, were inoculated intravenously or subcutaneously with various doses of yolk sac-grown rickettsia rickettsii. thirty-four macaques became febrile and exhibited signs of infection ranging from transient illness with a few days of fever to severe illness with subsequent death. the rash appeared more frequently in the macaques inoculated subcutaneously. febrile macaques that survived had leukocytosis, with concomitant neutrophilia. febrile macaques t ... | 1976 | 820224 |
| rickettsiae belonging to the spotted fever group from ticks in the tribec mountains. | rickettsiae of the spotted (sf) group were found in a selected locality of the tribec mountains in southern slovakia in 1974. the rickettsiae were found in 10.8% of females and 6.1% of males of haemaphysalis inermis and 7.3% of females and 4.8% of males of ixodes ricinus. no significant differences in the incidence were observed during the year. coxiella burneti was found in 1 male and 4 females of h. inermis and 1 male of i. ricinus in ad adjacent locality. antibodies against rickettsiae of the ... | 1976 | 820614 |
| proteins of typhus and spotted fever group rickettsiae. | purified radioactive rickettsiae were obtained from irradiated and cycloheximide-inhibited l cells, and their proteins were analyzed by polyacrylamide gel electrophoresis. rickettsial species could be distinguished by comparing the relative mobilities of constituent proteins after migration of two differentially labeled preparations in a single gel. distinct differences were observed in gel patterns of rickettsiae from the typhus and spotted fever groups, as well as with different species within ... | 1976 | 820639 |
| functional and morphologic changes during experimental rocky mountain spotted fever in guinea pigs. | experimental rocky mountain spotted fever was studied in guinea pigs following intraperitoneal inoculation of 10(7) rickettsia rickettsii. after a 2-day incubation period, animals developed fever, progressive emaciation, and scrotal swelling with necrosis. vasculitis, with increased small vessel permeability for colloidal carbon, was evident in cremaster muscles as early as 1 day after inoculation. inflammatory changes in vessels became progressively more severe as numbers of circulating rickett ... | 1976 | 822237 |
| demonstration of rickettsia rickettsii in the rhesus monkey by immune fluorescence microscopy. | indirect immune fluorescence was used to detect rickettsiae in the tissues of a primate inoculated subcutaneously with rickettsia rickettsii. rickettsiae were identified by indirect immuno fluorescence predominantly in skin, skeletal muscle, scrotum, testicles, nares, heart, kidney, liver, brain, spleen, pancreas, and larynx. cell culture assay confirmed the presence of infectious organisms in those specimens. | 1976 | 823168 |
| effect of vaccination schedule on immune response of macaca mulatta to cell culture-grown rocky mountain spotted fever vaccine. | the effect of vaccination schedule on the immune response of macaca mulatta to formalin-inactivated chicken embryo cell culture (cec)-grown rickettsia rickettsii vaccine was studied. schedules consisted of inoculation on day 1 only, on days 1 and 15, on days 1 and 30, on days 1, 8, and 15, or on days 1, 15, and 45. humoral antibody measured by microagglutination and indirect immunofluorescence and resistance to challenge with 10(4) plaque-forming units of yolk sac-grown r. rickettsii were assess ... | 1976 | 823173 |
| new assay of protective activity of rocky mountain spotted fever vaccines. | areas under the fever curves of guinea pigs inoculated with rocky mountain spotted fever vaccine over a restricted dose range and infected with a standardized dose of rickettsia rickettsii varied linearly with log10 dose of vaccine. a calculator was programmed to plot fever curves and calculate the vaccine dose that reduced the fever of infected animals by 50%. | 1976 | 823177 |
| prompt confirmation of rocky mountain spotted fever: identification of rickettsiae in skin tissues. | rickettsia rickettsii were identifiable by the immunofluorescence technique in skin specimens obtained by biopsy on days 4 and 8 of illness from patients with rocky mountain spotted fever. the immunofluorescence technique is regarded as a practical means of confirming the diagnosis during the early stages of illness before positive serologic reactions can be obtained. | 1976 | 824374 |
| infection cycle of rickettsia rickettsii in chicken embryo and l-929 cells in culture. | the infection cycle of rickettsia rickettsii, studied in slide chamber cultures of chicken embryo and l-929 cells, was found to be complex and did not conform to a one-step growth cycle. initial uptake kinetics resembled those established for rickettsia prowazekii, but subsequent events showed very marked differences. intracytoplasmic growth commenced exponentially without measurable lag. however, very soon after infection, intracytoplasmic rickettsiae began to escape from the host cell into the ... | 1976 | 825463 |
| study of rickettsioses in slovakia. iii. experimental infection of apodemus flavicollis melch. by rickettsiae of the spotted fever (sf) group isolated in slovakia. | experimental studies of infection of apodemus flavicollis, and for comparison of rickettsiaemia in clethrionomys glareolus and of susceptibility and antibody formation in white mice, with rickettsiae of the sf group isolated in slovakia, gave the following results: the species a. flavicollis reacted by the formation of antibodies on subcutaneous administration of rickettsiae, strain b, in an amount of 10(0.5) eid50/0.25 ml, whereas the white mouse only in an amount of 10(2.5). rickettsiae, strai ... | 1976 | 825571 |
| transport of retinol from the blood to the retina: involvement of high molecular weight lipoproteins as intracellular carriers. | 1976 | 179832 | |
| phosphofructokinase (isozymes) activation by theophylline or by 3',5' cyclic amp administration. | phosphofructokinase activity of rat thyroid, kidney and muscle can be enhanced by in vivo administration of theophylline or cyclic amp. this enhancement occurs in the different tissues to a different extent depending on the tissue-specific isozymes. thyroid and muscle phosphofructokinase which is mainly a-type, is strongly stimulated after administering theophylline in the drinking water over a 8 days period. the kidney enzyme which encompasses about 50% of each a and b type is activated to a le ... | 1977 | 193771 |
| scanning and transmission electron microscopy of rickettsia rickettsii propagated in cell culture. | scanning electron microscopy utilizing critical-point drying and transmission electron microscopy employing air-dried agar pseudoreplicas and critical-point dried carbon replicas were used to study the surface of rickettsia rickettsii propagated in cell culture. | 1977 | 18928 |
| tick-borne diseases in the united states: rocky mountain spotted fever and colorado tick fever. a review. | the historical, clinical, ecological, and epidemiological features of rocky mountain spotted fever and colorado tick fever, the two important tick-borne diseases in the united states, are reviewed. rocky mountain spotted fever, once considered a disease of the past, has again become a measurable public health problem. its nationwide incidence has steadily increased since 1960 and has reached record proportions in 1976. the various factors responsible for this trend as well as for the mortality r ... | 1977 | 19954 |
| massive occurrence of rickettsiae of the spotted fever group in fowl tampan, argas persicus, in the armenian s.s.r. | fowl tampans (argas persicus) collected in oktemberyan in the armenian s.s.r. in 1974 were found to be massively infected with rickettsiae of the spotted fever (sf) group. one isolated rickettsial strain, designated armenia 9, is antigenically related to, and probably identical with, strain armenia 11 and strain b of rickettsia slovaca, isolated from dermacentor marginatus ticks. strain armenia 9 grows readily in chick embryo yolk sacs and in chick embryo cell (cec) and l-cell cultures. it cause ... | 1977 | 22239 |
| plaque assay and cloning of scrub typhus rickettsiae in irradiated l-929 cells. | it was demonstrated that gamma-irradiated l-929 cells support plaque formation by three strains of rickettsia tsutsugamushi and representative species of the spotted fever and typhus group rickettsiae. sensitivity of the plaque assay for detection of viable scrub typhus rickettsiae was similar to that achieved with intraperitoneal inoculation of random-bred mice. the concentration of irradiated cells and the temperature and length of incubation were all found to affect plaque size. a technique c ... | 1977 | 69632 |
| a study on the relationship dose-effect in case of gamma-irradiation on leptospira. | 1977 | 98416 | |
| reaction of component recovered from cementum exposed to periodontal pocket with human serum. | 1977 | 267110 | |
| a comparison of serologic methods for diagnosis of rocky mountain spotted fever. | sera referred to the north carolina division of health services for rickettsial serology in 1974 were tested by complement fixation (cf), microimmunofluorescence (micro-if), microagglutination (ma) and hemagglutination (ha) for antibodies against rickettsia rickettsii. there was good agreement among micro-if,ma and ha tests in detecting antibody responses to this agent, but the cf test was definitely less sensitive than the others, even in illnesses with classical clinical manifestations of rock ... | 1977 | 401558 |
| identification of rickettsia rickettsii in a guinea pig model by immunofluorescent and electron microscopic techniques. | moribund guinea pigs infected with richettsia rickettsii were examined by necropsy, histology, immunofluorescence, electron microscopy, and serology. untreated animals died at 9 and 10 days after inoculation. animals given saline subcutaneously survived from 1 to 4 days longer. prolonged survival was accompanied by more severe lesions: scrotal necrosis; infarction of ears; and swollen, hemorrhagic footpads, epididymis, and cremaster muscle. histopathologic examination demonstrated that acute, ne ... | 1977 | 402079 |
| rocky mountain spotted fever: occurrence in massachusetts. | 1977 | 402694 | |
| differences in buoyant-density properties of coxiella burnetii and rickettsia rickettsii. | the pronounced change in the buoyant density of coxiella burnetii in cscl gradients that was caused by treatment with formalin or ultraviolet radiation was not observed with rickettsia rickettsii. | 1977 | 403144 |
| pathogenesis of infection with rickettsia rickettsii in the dog: a disease model for rocky mountain spotted fever. | dogs inoculated with rickettsia rickettsii developed a clinical syndrome ranging in severity from a mild febrile exanthema to death within six days after inoculation. the severity of the disease appeared to be dose-related, and the signs were comparable to r. rickettsii infection in humans on a clinical and hematological basis. dogs were rickettsemic for 10 to 14 days after infection. in most animals the level of rickettsemia was greater than or equal to 10(2.5) guinea pig intraperitoneal 50% in ... | 1977 | 405432 |
| studies of the coagulation and complement systems during experimental rocky mountain spotted fever in rhesus monkeys. | we studied the coagulation and complement systems during rocky mountain spotted fever in macaca mulatta experimentally infected with rickettsia rickettsii. ninety-one percent of monkeys infected intravenously with a high dose (10(6) plaque-forming units [pfu]) and 56% of monkeys infected with low doses (10(-1)-10(2) pfu) of r. rickettsii died after two to four days of illness. with the onset of fever and rickettsemia, animals developed hyperfibrinogenemia, mild thrombocytopenia, prolonged prothr ... | 1977 | 405434 |
| rocky mountain spotted fever and the avoidance of sulfonamides. | 1977 | 406374 | |
| rickettsiae of the spotted fever group in slovakia. | 1977 | 408981 | |
| laboratory-acquired rocky mountain spotted fever. the hazard of aerosol transmission. | nine patients with laboratory-acquired rocky mountain spotted fever were seen during the period 1971 to 1976. investigation of each case revealed either definite or probable exposure to an aerosol containing infectious rickettsiae; in no case was there evidence of parenteral exposure either by accidental self-inoculation or by tick bite. these illnesses are believed to represent infection acquired via the respiratory route. this report emphasizes the aerosol hazard of rickettsia rickettsii in th ... | 1977 | 409947 |
| [seroepidemiological investigations on the prevalence of rickettsial antibodies in man in the federal republic of germany (author's transl)]. | 1,600 random serum samples from inhabitants of hesse were investigated for rickettsial antibodies by complement fixation test. antibodies were found in 19 samples (1,2%) against rmsf-group antigen with titers between 1:10 and 1:640. these results confirm recent reports on natural foci of such rickettsial infections in the federal republic of germany. antibodies against rickettsia of the typhus-group or coxiella burnetii could not be detected by the complement fixation reaction. none of the sera ... | 1977 | 410727 |
| [isolation of rickettsia of the spotted fever group (sf group) from dermacentor marginatus ticks in tirol, austria]. | 1977 | 410728 | |
| in vitro guinea pig leukocyte reactions to rickettsia rickettsii. | the presence of cell-mediated immunity in rocky mountain spotted fever-infected guinea pigs was determined by two in vitro assays: whole blood lymphocyte transformation (lt) and macrophage migration inhibition. increased lt was detected as early as 1 week in guinea pigs infected with rickettsia rickettsii and treated with oxytetracycline and was detected by two weeks in infected but untreated guinea pigs. elevated lt was still detectable at 10 weeks postinfection. guinea pigs vaccinated with kil ... | 1977 | 412792 |