Publications

distribution of secretion systems in the genus legionella and its correlation with pathogenicity.	the genus legionella comprises over 60 species, which are important human pathogens. secretion systems in legionella pneumophila have been studied extensively because of the essential role of protein secretion in bacterial infection. however, there are few reports describing the secretion systems in non-l. pneumophila species. in this study, we analyzed the distribution of secretion systems in l. pneumophila and 18 species of non-l. pneumophila based on whole genome sequences. a total of 74 whol ...	2017	28352254
bacterial secretion system skews the fate of legionella-containing vacuoles towards lc3-associated phagocytosis.	the evolutionarily conserved processes of endosome-lysosome maturation and macroautophagy are established mechanisms that limit survival of intracellular bacteria. similarly, another emerging mechanism is lc3-associated phagocytosis (lap). here we report that an intracellular vacuolar pathogen, legionella dumoffii, is specifically targeted by lap over classical endocytic maturation and macroautophagy pathways. upon infection, the majority of l. dumoffii resides in er-like vacuoles and replicate ...	2017	28317932