Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| helicobacter pylori infection treated with a tripotassium dicitrato bismuthate and metronidazole combination. | seventy-two patients with h. pylori infection in their antral mucosa took part in the study. forty-three received metronidazole 400 mg t.d.s. for two weeks, plus de-nol tabs 2 b.d. for four weeks, and the remaining 29 patients received metronidazole 400 mg t.d.s. for two weeks plus de-nol liquid 5 ml q.d.s. for four weeks. seven of 57 h. pylori isolates were found to have pre-treatment metronidazole resistance. success, in terms of eradication of h. pylori, was assessed using a one-month post-tr ... | 1990 | 2129652 |
| low-dose cimetidine in the acute treatment of duodenal ulcer. comparison of a single nocturnal dose regimen with a twice daily regimen. | a 0.5 g daily dose of cimetidine was as effective as a 1 g dose in the acute treatment of duodenal ulcer patients in hong kong. the aims of the present study were, first, to determine whether low-dose cimetidine treatment was as effective as standard doses in acute duodenal ulcer treatment of patients in singapore, and second, to compare a single nocturnal dosage regimen with a twice daily regimen. in this single centre, double-blind, controlled trial, 282 patients with endoscopically proven duo ... | 1990 | 2129838 |
| morphological study of the gastric antral mucosa colonized by campylobacter pylori. | antral biopsies from 56 patients who underwent gastroscopy for upper gastrointestinal symptoms were studied by transmission electron microscopy. campylobacter pylori was demonstrated in specimens from 39 patients. the bacteria were present in 3 of the 8 normal specimens and in 36 of the 48 cases with chronic gastritis. electron microscopy showed that organisms were located deep the mucous layer in intimate relation with the luminar surface of the antral epithelium. no ultra-structural evidence w ... | 1990 | 2131923 |
| helicobacter pylori and chronic antral erosions: our experience. | 1990 | 2131932 | |
| the influence of high blood levels of urea on the presence of campylobacter pylori in the stomach: a clinical study. | in order to determine whether urea influences the presence of campylobacter pylori (cp) in the stomach, the incidence of this infection was determined in patients with chronic renal failure who received no treatment (group a) or underwent regular hemodialysis (group b). a third group was examined as control. biopsies from the gastric antrum were taken for histological investigation and for cp detection. no significant differences among the 3 groups of patients were found with regards to the inci ... | 1990 | 2131933 |
| the first cases of helicobacter pylori (campylobacter pylori) reported from costa rica. | two gastric antrum biopsies of each of 92 consecutive patients undergoing gastroendoscopy were studied. the first biopsy was cultured for helicobacter (campylobacter) pylori. the second specimen was fixed and processed for histopathological analysis. the bacteria were isolated from 34 (81%) of 42 patients with nonspecific chronic gastritis, 19 (90%) of 21 cases of duodenal or gastric peptic ulcer, and from 3 (23%) of 13 normal patients. the overall frequency of isolation was 62 (67%) of the 92 c ... | 1990 | 2134727 |
| [histopathologic changes associated with the presence of helicobacter pylori in antral mucosa]. | helicobacter pylori is a gram negative bacteria which has recently been associated to tissular changes of the upper digestive tract, however, the causal role has not yet been determined. of 150 patients studied, 63 had tissular changes associated to helicobacter pylori (hp), 8 had hp without tissular related changes (of whom 3 suffered bulbar ulcus and 1 gastric ulcus); the rest of the patients had hiatus hernia associated to distal esophagitis or pyloric stenosis; and only one patient was found ... | 1990 | 2135572 |
| [clinical significance of helicobacter pylori]. | 1990 | 2135580 | |
| [can epigastric pain and non-ulcerative dyspepsia in children and adolescents be campylobacter pylori infection?]. | the authors examined 263 children and adolescents aged 5-20 years who suffered from so-called non-ulcerative dyspepsia or epigastric pain, because of the suspected presence of campylobacter pylori. in 31.9% of the examined subjects direct microbiological methods revealed its presence in the gastroduodenal mucosa. the confidence limit of positive results of campylobacter pylori in the population is between 27.58% and 38.84%, the probability being 95%. the authors proved a mutual correlation betwe ... | 1990 | 2136426 |
| [cytotoxic changes in cell cultures induced by newly isolated strains of campylobacter pylori]. | suspensions of primocultures of two strains of camplyobacter pylori, isolated from bioptic materials collected from patients with nodular hyperplasia of the pyloric antrum and with gastric ulcers were inoculated to 20-hour confluent or almost confluent cell cultures line vero, mccoy and ma 104 in test tubes and petri dishes. both strains of c. pylori adhered markedly to cell lines vero and mccoy and after 72 hours led to marked morphological changes of the cells. the changes were characterized i ... | 1990 | 2136427 |
| [determination of antibodies to campylobacter pylori in children and adolescents with gastroduodenal disorders]. | serological examination of antibodies against campylobacter pylori was made in 195 boys and girls aged 9-20 years. in all on account of gastrointestinal complaints endoscopy was indicated. the results of microbiological and histological finding), in particular in the antrum and corpus of the stomach). positive titres antrum and body of the stomach were compared with results of the complement fixation test and the elisa reaction. antibodies against c. pylori were detected in 64 of the examined su ... | 1990 | 2136428 |
| [campylobacter pylori--relation to gastric pathology and the effect of bismuth therapy]. | twenty-four patients with symptoms of gastric dyspepsia and active chronic gastritis in the antral mucosa were examined for the presence of campylobacter pylori before and after treatment with bismuth salts (12 patients) and antacids (12 patients). bismuth, contrary to the used antacid, significantly reduced the finding of c. pylori in the antral mucosa and had a favourable effect on the active form of chronic antral gastritis. | 1990 | 2136429 |
| [morphologic changes in chronic active superficial campylobacter pylori-positive antrum gastritis after treatment with bismuth]. | the authors investigated the effect of one month bismuth treatment (bismuthi citrici 120 mg per capsule), 4 x 120 mg/day, on morphological changes of the gastric mucosa along with the effect on campylobacter pylori (cp) in a group of 23 probands with histologically verified active superficial cp positive antrum gastritis. the probands suffered only from functional dyspepsia, to eliminate the action of other disease of the digestive tract on chronic gastritis. complete eradication of cp occurred ... | 1990 | 2136460 |
| [peptic ulcer: a failure of the defense mechanisms of the gastroduodenal mucosa?]. | peptic ulcer is an heterogeneous and multifactorial disease. secretion of acid/pepsin is a critical permissive factor in gastroduodenal peptic ulceration. therapy of this disease has been based mostly on this principle. the sole presence of the aggressive factor, acid/pepsin, is not enough to explain peptic ulceration. mucosal defense (resistance) is another critical factor involved in pathogenesis of this disease. defects in some gastroduodenal defense mechanisms have been found in patients wit ... | 1990 | 2152272 |
| [physiopathological basis for the treatment of peptic ulcer]. | peptic ulcer pathophysiology has advanced in several ways during the last years; the following facts has been put forward: a) there has been recognized specific receptors controlling oxyntic cell secretion for histamine, acetylcholine, gastrin and prostaglandins. agonists and antagonists for the above mentioned receptors has been synthesized. the physiology of the proton-pump located at the luminal side of the mucous membrane has been clarified. this pump is responsible for hcl secretion and can ... | 1990 | 2152274 |
| [the igg antibody response in patients colonized by helicobacter pylori]. | the igg antibody response specific to helicobacter pylori was evaluated through elisa in a group of 92 gastric patients colonized by this bacteria. 74 had gastritis and 19 gastroduodenal ulcer. three control groups were studied in a similar way: normal adult volunteers (n = 17), adults with e coli or s typhi bacteremia (n = 30) and normal infants (n = 30). igg antibody response to h pylori was demonstrated in 98% of colonized patients and 0% of infants. asymptomatic individuals and those with ba ... | 1990 | 2152642 |
| increased tight junction width in two children with ménétrier's disease. | protein-losing enteropathy (ple) and edema are usually the most prominent clinical features in children with ménétrier's disease. however, the changes in gastrointestinal mucosa that can cause ple have not been described yet in children. we studied by electron microscopy the mucosa of the gastric fundus, which is the site where macroscopic changes are most prominent, in two children with ménétrier's disease. we found that tight junction width was increased to 10.5 +/- 0.94 nm (mean +/- 1 sd) in ... | 1990 | 2167358 |
| signature patterns of dna restriction fragments of helicobacter pylori before and after treatment. | the genomic dna of helicobacter pylori was studied by electrophoretic analysis of restriction endonuclease fragments. twenty seven isolates from eight patients in the united kingdom, obtained before and after treatment with nitrofurantoin, and two reference strains from australia and peru were investigated. digestion of dna with haeiii, which gave the clearest band pattern of the 20 enzymes tested, showed that each set of isolates from a single patient had a unique band pattern. the dna signatur ... | 1990 | 2169483 |
| possible role of leukotrienes in gastritis associated with campylobacter pylori. | this study was done to evaluate the role of leukotrienes (lts) in gastritis associated with campylobacter pylori. biopsy specimens of gastric mucosa were obtained endoscopically from 18 patients with nonulcer dyspepsia for bacteriological and histological examination and extraction of lts. there was correlation between the ltb4 level in the mucosa and the degree of gastritis evaluated histologically. the level was higher when infiltration of neutrophils in the gastric mucosa was more extensive. ... | 1990 | 2170499 |
| comparison of anti-helicobacter (campylobacter) pylori igg antibodies between different areas of belgium. | we have collected sera from 4053 patients of different parts of belgium. sera were randomly selected whatever the kind of pathology. anti-helicobacter (campylobacter) pylori igg were determined with an elisa technique using whole formalized bacteria. the results suggest that the mean antibody titres differ between various areas, with an overall higher prevalence in the north-western part of the country. | 1990 | 2173316 |
| drug therapy for helicobacter pylori infection: problems and pitfalls. | antibacterial chemotherapy against helicobacter pylori is currently being assessed by open or randomized controlled clinical studies for its efficacy in eradicating this bacterium from the stomach of patients with gastritis or gastroduodenal ulcer. whereas there is presently no "optimal" agent and treatment scheme, the combination of some antibiotics (metronidazole, tinidazole, amoxicillin) with bismuth salts proves definitely superior in vivo to either of these agents administered alone. severa ... | 1990 | 2174642 |
| recent advances in infectious diseases. | 1990 | 2175934 | |
| comparison of different tests for helicobacter pylori. | 1990 | 2178404 | |
| helicobacter pylori: controversies and an approach to management. | helicobacter pylori (formerly, campylobacter pylori) is a gram-negative, spiral-shaped bacterium with a strong affinity for gastric-type epithelium. convincing evidence indicates that h. pylori plays an etiologic role in the development of chronic, nonspecific gastritis, and it may play an important role in the pathogenesis of duodenal ulcer disease. an etiologic role for this organism in chronic gastric ulceration, nonulcer dyspepsia, and gastric carcinoma is not established. whereas the diagno ... | 1990 | 2179647 |
| helicobacter pylori and the pathogenesis of gastroduodenal inflammation. | helicobacter pylori is a newly discovered gram-negative bacterium that lives in the human stomach and duodenum. infection with this organism is strongly associated with type b antral gastritis and with peptic ulcer disease. recent evidence from human volunteer studies, therapeutic trials with antimicrobial agents, and experiments with animal models indicates that h. pylori plays an etiologic role in the pathogenesis of type b gastritis. gastric metaplasia is observed in virtually all patients wi ... | 1990 | 2181029 |
| [campylobacter pylori-helicobacter pylori. a long development]. | 1990 | 2184426 | |
| campylobacter (helicobacter) pylori. is peptic disease a bacterial infection? | 1990 | 2184791 | |
| effect of colloidal bismuth subcitrate on symptoms and gastric histology in non-ulcer dyspepsia. a double blind placebo controlled study. | the aim of this study was to determine the effect of colloidal bismuth subcitrate (de nol) on symptoms and gastric histology in patients with non-ulcer dyspepsia. in a single centre trial, patients with food related upper abdominal pain not caused by ulcer disease were randomised to receive one tablet of colloidal bismuth subcitrate or matching placebo four times daily for eight weeks. seventy three patients were entered and 51 completed the trial: 28 patients in the colloidal bismuth subcitrate ... | 1990 | 2186982 |
| purification and characterization of urease from helicobacter pylori. | urease was purified 112-fold to homogeneity from the microaerophilic human gastric bacterium, helicobacter pylori. the urease isolation procedure included a water extraction step, size exclusion chromatography, and anion exchange chromatography. the purified enzyme exhibited a km of 0.3 +/- 0.1 mm and a vmax of 1,100 +/- 200 mumols of urea hydrolyzed/min/mg of protein at 22 degrees c in 31 mm tris-hcl, ph 8.0. the isoelectric point was 5.99 +/- 0.03. molecular mass estimated for the native enzym ... | 1990 | 2188975 |
| [helicobacter pylori and gastric pathology]. | 1990 | 2193600 | |
| [does helicobacter pylori have a direct proteolytic effect in ulcerative disease?]. | helicobacter pylori (h.p.), has been shown, experimentally, to exert a proteolytic activity against mucous fractions. aim of this study was to assess the prevalence of h.p. in peptic ulcer and to analyze its possible influence on gastric mucus components, on peptic activity in gastric juice and the possible action on peptic secretion. 223 patients undergoing upper gastrointestinal endoscopy were analyzed for the presence of h.p. in the mucosa: 99 duodenal ulcer patients (d.u.), 58 gastric ulcer ... | 1990 | 2194877 |
| gastritis in the elderly. | the elderly have an increased prevalence of gastritis and the complications associated with it. the two major classes of acute and chronic gastritis, type a and b, are discussed as they relate to clinical findings, histologic features, and pathogenesis. an age-related increase in the frequency of helicobacter pylori (formerly campylobacter pylori) infection in the elderly parallels the known age-related increase in the prevalence of gastritis. the close association between gastritis in the elder ... | 1990 | 2194946 |
| helicobacter pylori (formerly campylobacter pyloridis/pylori) 1986-1989: a review. | 1990 | 2196282 | |
| a simple method to detect helicobacter pylori in gastric specimens. | 1990 | 2196955 | |
| bismuth therapy in gastrointestinal diseases. | bismuth therapy has shown efficacy against two major gastrointestinal disorders: peptic ulcer disease and diarrhea. in peptic ulcer disease it is as effective as the h2-receptor antagonists, costs considerably less, and offers a lower rate of relapse. when helicobacter pylori is implicated, bismuth acts as an antimicrobial agent, suppressing the organism but not eliminating it. in recent studies, bismuth compounds have been used with conventional antibiotics, producing elimination of the organis ... | 1990 | 2199292 |
| immunocytochemical detection of helicobacter pylori in formalin fixed tissue biopsy specimens. | 1990 | 2199535 | |
| survival of helicobacter pylori in water and saline. | 1990 | 2199542 | |
| helicobacter pylori: bridging the credibility gap. | in summary, therefore, there are interesting associations between h pylori, duodenal ulcer, and non-ulcer dyspepsia. in type b gastritis there may be enough evidence to suggest a causal role. the relation between gastritis and upper gastrointestinal symptomatology, however, remains contentious. the relation between h pylori and acid secretion may be more intimate than was previously thought. 'pylorites' must temper their enthusiasm and provide hard data; 'schwartzians' must broaden their horizon ... | 1990 | 2201586 |
| helicobacter (= campylobacter) pylori in africa. | epigastric pain is a common complaint throughout africa, mostly in the form of non-ulcer dyspepsia. it has recently been suggested that helicobacter (= campylobacter) pylori, a bacterium that colonizes the gastric mucosa and causes type b gastritis, may be the cause of this epigastric pain. this paper reports the endoscopic, histological and bacteriological findings in 57 patients presenting with epigastric pain to the university of maiduguri teaching hospital during one year, together with a re ... | 1990 | 2202107 |
| effects of sucralfate and sulglycotide treatment on active gastritis and helicobacter pylori colonization of the gastric mucosa in non-ulcer dyspepsia patients. | we conducted a double-blind randomized treatment study on patients affects by non-ulcer dyspepsia in whom multiple biopsy specimens showed active gastritis. patients were given either 3 g/day of sucralfate (n = 39) or 600 mg/day of sulglycotide (n = 50) for 6 wk, a glycopeptide isolated from pig duodenum constituents. endoscopy was carried out at baseline and at the end of treatment. we took biopsies from the gastric body (twice) and antrum (six times) at each endoscopy in order to determine gra ... | 1990 | 2202200 |
| [efficacy of a bismuth combination preparation. efficacy in the treatment of chronic active gastritis and non-ulcerous dyspepsia]. | in an open, randomized controlled study, the effect of a combined bismuth preparation, bismuth nitrate and bismuth aluminate on the elimination of helicobacter pylori, inflammatory activity in the gastric mucosa in chronic type b gastritis, and on the patient's symptoms was investigated. included in the study were 36 patients with non-ulcerous dyspepsia and chronic gastritis. twelve patients (group a) received 4 x 1 tablet a day (800 mg total daily dose), 12 patients (group b) 2 x 2 tablets a da ... | 1990 | 2202619 |
| gastrointestinal function and structure in hiv-positive patients. | we examined 19 patients (17 men) with human immunodeficiency virus (hiv) infection and gastrointestinal symptoms to determine whether those symptoms were due to either a gastrointestinal tract infection or a defect in mucosal absorption because of an enteropathy. the erythrocyte folate and serum vitamin b12 levels were within normal limits in all of the patients. the serum ferritin level was elevated in 12. the xylose absorption test results were abnormal in 8 of the 13 patients able to complete ... | 1990 | 2207920 |
| identification of campylobacter pylori by endoscopic brush cytology. | to investigate the value of papanicolaou-stained endoscopic brush samples in the diagnosis of campylobacter pylori infection of the upper gastrointestinal tract, 138 brush and biopsy samples from the esophagus, stomach, and duodenum, taken concomitantly, were reviewed retrospectively. in 35 cases, campylobacter-like organisms (clos) were found in both cytology and biopsy samples. in 15 cases, clos were seen in biopsy material only, and in 8 cases, clos were found in cytology material only. clos ... | 1990 | 2209347 |
| development of a human stomach explant organ culture system to study the pathogenesis of helicobacter pylori. | these studies were undertaken to define conditions under which helicobacter (formerly campylobacter) pylori and viable human gastric mucosa could coexist in tissue culture with the ultimate goal of developing an in vitro experimental model which could be used to study interactions between h. pylori and gastric epithelium. antral gastric biopsies obtained at upper endoscopy were placed in culture in either cmrl-1066 or keratinocyte growth media and incubated at 37 degrees c in either an oxygen-en ... | 1990 | 2210096 |
| a small animal model of human helicobacter pylori active chronic gastritis. | isolation of a spiral-shaped bacterium closely related to helicobacter pylori from the cat stomach made it possible to investigate new small animal models of gastric infection. pure cultures of this bacterium, provisionally named "helicobacter felis," were fed to germ-free mice. the organism colonized the stomach in large numbers in mucus and deep in the gastric pits and showed the same gastric trophism found with h. pylori. significant histopathology was seen in all h. felis-infected mice. at 2 ... | 1990 | 2210240 |
| reduction of gastric ulcer recurrence after suppression of helicobacter pylori by cefixime. | the effect on the recurrence of gastric ulcers after suppression of helicobacter pylori by combined treatment with cimetidine and the antimicrobial drug cefixime was investigated. twenty one of 43 patients with endoscopically proved gastric ulcer and h pylori infection were randomly assigned to receive cimetidine 800 mg daily for 12 weeks; the remaining 22 patients received cimetidine 800 mg daily for 12 weeks plus cefixime 100 mg daily for the last two weeks. after treatment, 88% of 17 patients ... | 1990 | 2210464 |
| adjuvant antibiotic therapy in duodenal ulcers treated with colloidal bismuth subcitrate. | persistence of helicobacter pylori after duodenal ulcer healing is associated with high rates of ulcer relapse. we compared colloidal bismuth subcitrate alone with cbs combined with one of four antibiotic regimens in the treatment of duodenal ulcers. endoscopy and antral biopsies were performed before treatment and four weeks afterwards. biopsy specimens were examined for histological evidence of gastritis and by gram stain and culture for h pylori infection. altogether 141 patients were allocat ... | 1990 | 2210469 |
| geographic association of helicobacter pylori antibody prevalence and gastric cancer mortality in rural china. | to examine the geographic association between helicobacter pylori infection and gastric cancer, we have assessed the prevalence of igg antibodies to h. pylori in plasma samples taken in 1983 from 1882 men, aged 35-64 years, in 46 rural counties of the people's republic of china. the gastric cancer mortality rates in these countries in 1973-75 varied from 3 per 1,000 (cumulative rate, 0-64 years) to 69 per 1,000, while the proportions of the population positive for h. pylori antibodies (based on ... | 1990 | 2210881 |
| serum pepsinogen i and gastrin concentrations in children positive for helicobacter pylori. | serum pepsinogen i, serum gastrin concentration, and inflammatory scores were measured in a population of 71 children undergoing upper gastrointestinal endoscopy for investigation of upper abdominal pain. forty four were initially colonised with helicobacter pylori. the indices were measured before treatment (in 71 children), one month (in 41 children), and six months (in 21 children) after stopping treatment. before treatment there was a significant correlation between serum pepsinogen concentr ... | 1990 | 2212069 |
| generation of ammonia and mucosal lesion formation following hydrolysis of urea by urease in the rat stomach. | we examined the morphological changes in gastric mucosa and the generation of ammonia after exposure of the rat stomach to urea in the presence of urease, in attempts to investigate a pathophysiological role of urea, urease, and ammonia system in gastric ulcer diseases. exposure of the stomach for 20 min to 2 ml urea (0.025-0.2%) together with urease (100 iu) induced histological damages in a concentration-related manner. either urea or urease alone did not induce any histological change in the ... | 1990 | 2212535 |
| the susceptibility of campylobacter pylori to antiulcer agents and antibiotics. | the antibacterial activities of antiulcer agents and antibiotics against campylobacter pylori were studied. the mic90 values of three kinds of antibiotics--macrolides, beta-lactams, and metronidazole--were 0.05-0.78, 0.39-1.56, and 12.5 micrograms/ml, respectively. they were more active than antiulcer agents such as h2-blockers and cetraxate with mic90 values of greater than or equal to 1,600 and greater than 1,600 micrograms/ml, respectively. especially, clarithromycin, a new derivative of eryt ... | 1990 | 2212539 |
| evidence for gastric mucosal cell invasion by c. pylori: an ultrastructural study. | it is now generally accepted that campylobacter pylori is closely associated with peptic ulcer disease and chronic type b gastritis. whether c. pylori is the direct etiologic cause of either or both of these illnesses remains unclear. possible pathophysiologic effects of c. pylori are still a matter of debate and conjecture. utilizing a small group of patients with gastric ulcers and chronic gastritis, we examined the ultrastructural relationship between c. pylori and gastric cells. forty-eight ... | 1990 | 2212556 |
| campylobacter pylori interactions with gastric cell tissue culture. | many investigators have reported that gastric mucosal biopsies of patients with chronic gastritis and peptic ulcer disease show the presence of campylobacter pylori in a large majority of cases. histologic examinations of such tissues indicate a close approximation of c. pylori with gastric surface epithelial cells. a recent report has described both adherence and cell invasion of gastric cells by c. pylori. using a transmission electron microscope, we have examined the interaction between c. py ... | 1990 | 2212557 |
| [examination of distribution of helicobacter pylori on gastric mucosa using dye endoscopy]. | 1990 | 2214287 | |
| [campylobacter pylori and its role in the pathogenesis of selected diseases of the stomach and duodenum]. | 1990 | 2216966 | |
| clinical recognition and evaluation of peptic ulcer disease. | when a patient has epigastric pain that worsens 1 to 3 hours after meals, the possibility of peptic ulcer disease should be considered. completely typical clinical presentations in patients younger than age 50 justify empirical therapy when no physical or laboratory findings suggest a mimicking disorder. esophagogastroduodenoscopy should be undertaken when response to therapy is incomplete, symptoms recur quickly, or dyspeptic symptoms present for the first time in a patient older than age 50. w ... | 1990 | 2216988 |
| [chronic gastritis. pathogenesis, clinical aspects and therapy]. | based on clinical and histopathological features, three different types of chronic gastritis can be distinguished: gastritis a is confined to the proximal stomach and is the result of an autoimmunological process with antibodies against parietal cells and intrinsic factor. it is a rare disorder and may lead to pernicious anaemia. distal, antral gastritis b is caused by an infection of the gastric mucosa with helicobacter pylori (hp). its incidence increases with age (greater than 50% above age 5 ... | 1990 | 2218459 |
| [the histological diagnosis of chronic gastritis. a german proposal for an integrated nomenclature]. | the gastrointestinal pathology study group of the german pathological society has drawn up a proposal for a unifying nomenclature for the graduation and classification of gastritis. the severity of chronic gastritis is divided into 4 grades (minimal, light, moderate and severe) and the activity of the process is characterized by 3 grades (grade 1, 2 and 3 activity). in addition, the presence or absence of helicobacter pylori (formerly campylobacter pylori), the extent and type of intestinal meta ... | 1990 | 2218460 |
| [current perspectives in ulcer disease]. | 1. helicobacter pylori has been associated with chronic type-b gastritis, which in turn is always present in duodenal ulcer patients; therefore, it is likely that helicobacter pylori is an important cofactor in the pathogenesis of peptic ulcer disease. an eradication of helicobacter pylori is associated with the reduced ulcer relapse rate, but an effective therapy for eradication is not yet available and should be restricted to experimental protocols. 2. omeprazole is an antagonist of the proton ... | 1990 | 2218969 |
| hyperplastic gastric polyps associated with persistent helicobacter pylori infection and active gastritis. | we report two cases of patients with 3-yr histories of upper gastrointestinal symptoms, hyperplastic gastric polyps, and active chronic gastritis. biopsies retrospectively stained with giemsa revealed the persistent presence of helicobacter pylori (hp) in gastric biopsies of both patients throughout the 3 yr. after treatment with amoxicillin and bismuth subsalicylate, both became asymptomatic, one demonstrating disappearance and recurrence of the gastric polyps in conjunction with the hp. these ... | 1990 | 2220735 |
| disaccharidases in duodenal biopsies in helicobacter pylori-positive patients. | 1990 | 2220753 | |
| association of helicobacter pylori infection with dyspeptic symptoms in patients undergoing gastroduodenoscopy. | to determine the prevalence of helicobacter pylori in patients with non-ulcer dyspepsia and ulcer disease as well as in a control population undergoing endoscopic retrograde cholangiopancreatography (ercp) for suspected pancreatic or biliary disease. | 1990 | 2220879 |
| the prevalence of helicobacter pylori in nonulcer dyspepsia. importance of stratification according to age. | helicobacter pylori (formerly campylobacter pylori) is causally related to active antral gastritis and is highly associated with duodenal and gastric ulcers. however, the relationship of h pylori to nonulcer dyspepsia is less clear. we determined the presence of h pylori in unselected patients who were undergoing upper gastrointestinal tract endoscopy, and we found a prevalence of 37% in 110 patients with nonulcer dyspepsia that was similar to previous data. patients with nonulcer dyspepsia who ... | 1990 | 2222090 |
| in vitro susceptibility of helicobacter pylori to the new oral cephalosporins cefpodoxime, ceftibuten and cefixime. | the in vitro activity against 30 helicobacter pylori strains of three new third generation cephalosporins, cefpodoxime, ceftibuten and cefixime, which can be administered orally, was determined using an agar dilution technique under microaerophilic conditions. the mic50 and mic90 of cefpodoxime was 0.5 and 4.0 micrograms/ml respectively, of ceftibuten 2.0 and 8.0 micrograms/ml, and of cefixime 0.06 and 0.5 microgram/ml. all antibiotics showed good activity against helicobacter pylori, cefixime h ... | 1990 | 2226500 |
| natural history of congestive gastropathy in cirrhosis. the liver study group of v. cervello hospital. | in a prospective study of the natural history of congestive gastropathy, 212 consecutive cirrhotic patients (75 treated with sclerotherapy) were included. mean follow-up was 46 months. mild gastropathy (mosaiclike pattern) was found in 110 patients and severe gastropathy (granular mucosa with cherry spots) was found in 20. prevalence of helicobacter pylori, formerly campylobacter pylori, was 50% in patients without, 43% in those with mild, and 28% in those with severe gastropathy. congestive gas ... | 1990 | 2227271 |
| gastrointestinal side-effects of octreotide during long-term treatment of acromegaly. | gastrointestinal side-effects of prolonged therapy (greater than 2 yr) with the long-acting somatostatin analog octreotide were studied in 10 acromegalic patients. after 2 yr of therapy, 6 of 10 patients had newly developed gallstones, complicated by cholangitis and jaundice in 1. serum vitamin b-12 concentrations declined in all 10 patients [from 380 +/- 32 to 172 +/- 21 pmol/l (mean +/- se); p = 0.023] and became abnormally low in 4. gastric biopsy specimens, obtained during gastroscopy (9 pat ... | 1990 | 2229321 |
| evaluation of two monkey species (macaca mulatta and macaca fascicularis) as possible models for human helicobacter pylori disease. | endoscopic, histologic, and microbiologic evaluations of 21 cynomolgus and 34 rhesus monkeys for naturally occurring helicobacter pylori infection were done. h. pylori was never isolated from any cynomolgus monkey, but was found in 12 rhesus monkeys. a general correlation existed between a positive culture and a gastric inflammatory response. inoculation challenges were then undertaken. four cynomolgus and five rhesus monkeys received two different h. pylori strains isolated from humans. five rh ... | 1990 | 2229353 |
| evaluation of the indoxyl acetate hydrolysis test for rapid differentiation of campylobacter, helicobacter, and wolinella species. | a total of 410 well-defined campylobacter, helicobacter, and wolinella strains, comprising 26 named species, subspecies, and defined groups, were tested for indoxyl acetate hydrolysis by a disk method by using disks prepared at the centers for disease control, atlanta, ga. all c. coli (43 strains), c. cryaerophila (34 strains), c. fennelliae (5 strains), c. fennelliae-campylobacter-like organism 3 (2 strains), c. jejuni (66 strains), c. jejuni subsp. doylei (3 strains), hippurate-negative c. jej ... | 1990 | 2229360 |
| helicobacter pylori: has it a part in the lesion of the gastroesophageal reflux? | 1990 | 2230279 | |
| ultrastructure of a spiral micro-organism from pig gastric mucosa ("gastrospirillum suis"). | the ultrastructural features of a helical-shaped bacterium occurring in the stomach of pigs, within the mucus on the mucosal surface of antral pits, were examined. the bacterial cell had three to eight spiral turns, flattened and truncated ends and was approximately 4.0 microns long and 0.6 microns wide. in some sections, up to six flagella, about 22 nm in diameter, were seen arising from each pole. the cytoplasm contained sparse, irregular granules, numerous ribosomes and large single-layered m ... | 1990 | 2231673 |
| helicobacter: new name, new hypothesis involving type of gastric cancer. | 1990 | 2232049 | |
| [detection of antibodies to helicobacter pylori with the immunoenzyme test and indirect immunofluorescence]. | sera from 56 adult patients were screened for the presence of igg antibodies against helicobacter pylori by enzyme immunoassay and indirect immunofluorescence. in addition, the detection of helicobacter pylori in antral biopsy specimens was attempted by culture and histological methods. colonisation of the antrum mucosa with helicobacter pylori was observed in 39 of the 56 patients. igg antibodies against helicobacter pylori were detected by enzyme immunoassay in 34 of 39 infected patients. thus ... | 1990 | 2233106 |
| a newly recognized fastidious gram-negative pathogen as a cause of fever and bacteremia. | we identified a motile, curved, gram-negative bacillus as the cause of persistent fever and bacteremia in two patients with symptomatic human immunodeficiency virus infection. the same organism was subsequently recovered from a bone marrow-transplant recipient with septicemia and from two immunocompetent persons with week-long febrile illnesses. all the patients recovered after antimicrobial therapy. | 1990 | 2233947 |
| [campylobacter pylori infection. results of an investigation of 130 patients]. | after recalling the main data on diagnosis, pathogenesis and treatment of cp infection, the results of a study on 130 patients are presented. | 1990 | 2234480 |
| [identification of campylobacter jejuni by using a biotinylated probe]. | a dna biotinylated probe for the rapid identification of campylobacter jejuni in culture (enzo biochem, new york) has been evaluated. the hybridized biotinylated dna probe is detected by its interaction with streptavidin linked to horseradish peroxidase. sixteen strains of c. jejuni, including type strain. 24 strains of other campylobacter and helicobacter species, and 59 strains of other general have been studied. the probe was highly sensitive (100%) and specific (100% inside the genera campyl ... | 1990 | 2235085 |
| do non-steroidal anti-inflammatory drugs or smoking predispose to helicobacter pylori infection? | susceptibility to helicobacter pylori infection is a poorly understood phenomenon. this study was undertaken to establish whether either smoking or chronic non-steroidal anti-inflammatory drug (nsaid) consumption might in some way predispose to h. pylori infection and hence lead to peptic ulceration. serological evidence of h. pylori infection was assessed in 100 consecutive subjects receiving nsaids without any evidence of gastrointestinal upset and 100 matched controls. all subjects had a full ... | 1990 | 2235801 |
| epidemiology in peptic ulcer disease. current status and future aspects. | peptic ulcer incidence is declining. a decreased prevalence of smokers together with other factors have contributed to this change. the widespread use of non-steroidal anti-inflammatory drugs (nsaid) has increased the incidence of ulcer in the older population and serious complications, such as perforation and bleeding, have been observed especially in older women. helicobacter pylori infection is virtually always present in duodenal and gastric ulcer and active chronic gastritis, but not prepyl ... | 1990 | 2237275 |
| helicobacter pylori: fact or fiction? | the recent isolation and classification of the spiral gastric bacteria helicobacter pylori has led to an explosion of worldwide research. the data strongly suggest that h. pylori is the causative agent for type-b active chronic gastritis. the role of h. pylori in duodenal ulcer awaits clarification, and, more importantly, potential treatment regimens need clear documentation and further detailed research. the past decade has revealed many intriguing facts about h. pylori infection. if, during th ... | 1990 | 2237277 |
| [the frequency of demonstration of campylobacter pylori]. | in 376 patients who underwent gastroscopy the presence of campylobacter pylori by microscopy, bacterial culture and urea test was studied. additionally, the histological examination of the antral mucosa was performed. the organisms were detected in 47.9% of the biopsy specimens (37.2% in normal endoscopic findings and 70% in duodenal ulcers). dependence on sex was not found and also no significant difference of campylobacter pylori detection in patients younger than 45 years compared with those ... | 1990 | 2238751 |
| elimination of helicobacter pylori under treatment with omeprazole. | biopsies from the stomachs (antrum and corpus) of 201 patients with peptic ulcers or reflux oesophagitis were retrospectively investigated for the effect of treatment with omeprazole on the elimination of helicobacter pylori (hp) and on gastritis. of 64 patients without gastritis two (3.1%) developed gastritis during treatment. among 134 patients with hp gastritis undergoing treatment, 48 (35.8%) experienced no hp elimination, in 41 (30.6%) there was hp elimination from the antrum, but hp persis ... | 1990 | 2238754 |
| [gastritis: immunohistochemical detection of specific and nonspecific immune response to helicobacter pylori]. | granulocyte infiltration was studied in 88 biopsies of antrum mucosa from patients with b-gastritis. evidence of iga-, igg- and igm-antibodies as well as of lysozyme in the mucosa was demonstrated by immunohistochemical methods. helicobacter pylori (hp) is coated by antibodies and a significant correlation between extent of opsonisation and number of plasma cells in the connective tissue of the lamina propria could be stated. thus, the infiltration of plasma cells is a specific immune response a ... | 1990 | 2238761 |
| [peptic ulcer and helicobacter pylori]. | 1990 | 2240930 | |
| seroprevalence of helicobacter pylori in seventh-day adventists and other groups in maryland. lack of association with diet. | to evaluate the possible role of diet in the transmission of helicobacter pylori, we compared h pylori seroprevalence among seventh-day adventists (who are vegetarian and abstain from alcohol, caffeine, and meat; n = 94) and two non-seventh-day adventist control groups (n = 168). with the use of an enzyme-linked immunosorbent assay h pylori antigen prepared in a french pressure cell, we found no difference in seroprevalence among these groups; however, seropositivity strongly correlated with age ... | 1990 | 2241444 |
| [helicobacter pylori, peptic diseases and colloid bismuth]. | 1990 | 2244100 | |
| helicobacter pylori infection and chronic gastritis: clinical, serological, and histologic correlations in children treated with amoxicillin and colloidal bismuth subcitrate. | twenty-three children with helicobacter (campylobacter) pylori-associated chronic gastritis are reported. family history of peptic disease, previous digestive procedures, and nonspecific epigastric pain were the most frequently encountered clinical features. antral nodularity at endoscopy and histologic evidence of follicular gastritis were characteristic morphological aspects. rapid urease tests suggested the diagnosis in 90% of patients. significant increases of serum igg and iga against helic ... | 1990 | 2246711 |
| [current perspectives in the pathogenesis and the treatment of duodenal ulcer]. | 1990 | 2247183 | |
| helicobacter pylori and associated duodenal ulcer. | twenty three children with coexistent duodenal ulcer and helicobacter pylori infection were treated with either two weeks of amoxycillin (25 mg/kg/day) in addition to six weeks of cimetidine, or cimetidine alone. endoscopy with antral and duodenal biopsies for urease test, microaerophilic culture, and histological studies were performed at entry, six weeks, 12 weeks, and at six months. children with persistent h pylori infection at six weeks were given a further two weeks' course of amoxycillin. ... | 1990 | 2248531 |
| helicobacter pylori. | 1990 | 2248546 | |
| [c. pylori colonization of the mucosa in patients with chronic ulcerative and non-ulcerative gastropathies]. | c. pyloridis colonization was investigated in a selected group of 58 patients with upper gastrointestinal disorders submitted to endoscopy and biopsy. the following results were registered. c. pyloridis was isolated in 14 out of 18 cases of active chronic gastritis, in 15 out of 24 cases of non active chronic gastritis, and 7 out of 8 cases of antral ulceration. a negative finding was registered in 8 patients whose gastric mucosa was normal. therefore, the authors consider as valid the etiopatho ... | 1990 | 2248870 |
| helicobacter pylori and gastric carcinoma. serum antibody prevalence in populations with contrasting cancer risks. | this investigation examined the correlation between helicobacter pylori (hp) infection, as reflected in immunoglobulin g serum antibodies, and the risk of gastric cancer. serum samples were obtained from populations with contrasting gastric cancer risks. the highest prevalence of hp infection, 93%, was observed in the adult population at highest gastric cancer risk, the residents of pasto, colombia. in the lower risk colombian city of cali, a 63% overall prevalence rate was found. both children ... | 1990 | 2249197 |
| [helicobacter pylori]. | ever since 1983 when marshall & warren succeeded in cultivating helicobacter pylori (hp) (previously known as campylobacter pylori) a high incidence thereof has been demonstrated in patients with ulcers and non-ulcerous dyspepsia. helicobacter pylori is easily diagnosed via microscopy, cultivation and serological tests. the bacterium may be treated with antibiotics or the ulcer drug bismuth subcitrate (de-nol). the pathogenetic role of hp is not clear. some studies have shown a lower recurrence ... | 1990 | 2251107 |
| the who's and when's of therapy for helicobacter pylori. | 1990 | 2252013 | |
| helicobacter pylori infection: a simplified diagnostic approach. | we evaluated the diagnostic accuracy of endoscopic finding of nodular antritis and rapid urease test (rut) in order to simplify the approach to the diagnosis of helicobacter pylori (h. pylori) infection. forty-four consecutive patients (mean age 7.9 yr, range 6-13 yr) referred because of recurrent abdominal pain as the main symptom, were prospectively investigated for the presence of h. pylori. h. pylori positivity or negativity was defined as the concordance of two of the following tests: rut, ... | 1990 | 2252019 |
| helicobacter pylori infection in patients with acquired immune deficiency syndrome. | a controlled study was conducted on patients with human immunodeficiency virus (hiv) infection referred for upper endoscopy to evaluate the prevalence of helicobacter pylori (h. pylori) infection. four different stains and culture for h. pylori were performed on biopsy specimens from the gastric antrum. sixteen (40%) of 40 patients with acquired immune deficiency syndrome (aids) or aids-related complex (arc) were diagnosed to be infected with h. pylori versus 14 (39%) of 36 age-matched control p ... | 1990 | 2252020 |
| helicobacter (campylobacter) pylori: a new twist to an old disease. | 1990 | 2252384 | |
| medical treatment of antral gastrin cell hyperfunction: role of nonantisecretory therapy. | antral g cell hyperfunction (agch) is a rare condition, often associated with severe duodenal ulcer disease poorly responsive to medical therapy. up to now, no studies have been designed to investigate a possible role of medical treatment in the management of this syndrome. in this study we treated 9 agch patients with duodenal ulcer, unhealed with the prolonging standard doses of h2 antagonists (300 mg/day ranitidine or 800 mg/day cimetidine), with a nonantacid therapy, tripotassium dicitrato b ... | 1990 | 2253824 |
| relation of helicobacter pylori to the human gastric mucosa in chronic gastritis of the antrum. | the spatial relations between bacteria and the affected tissues can indicate pathogenic mechanisms. this study was undertaken to define the spatial relation of helicobacter pylori to the human gastric mucosa. antibodies against gastric mucus and ruthenium red were used to stabilise the glycoprotein structure of the mucus and glycocalyces in antral biopsy specimens from eight patients infected with h pylori. the location of organisms and ultrastructural features were assessed using systematic sca ... | 1990 | 2253904 |
| evaluation of 13c-urea breath test in the detection of helicobacter pylori and in monitoring the effect of tripotassium dicitratobismuthate in non-ulcer dyspepsia. | sixty nine patients with non-ulcer dyspepsia have been studied with endoscopy, biopsy, quick urease (clo) test, helicobacter pylori culture, and the 13c-urea breath test before and after treatment with tripotassium dicitratobismuthane (denol) two tablets twice daily for four weeks. symptoms of non-ulcer dyspepsia were recorded using a standard questionnaire. using h pylori culture as the gold standard, the sensitivity of the 13c-urea breath test was 90%, the specificity 98.6%, and the accuracy 9 ... | 1990 | 2253905 |
| paf-acether synthesis by helicobacter pylori. | clinical studies suggest that helicobacter pylori may play a role in the pathogenesis of gastroduodenal ulcers in man but direct evidence of mucosal injury by this microorganism is still lacking. paf-acether (paf) causes a number of disorders including ischaemic bowel necrosis and gastroduodenal ulceration. since paf is produced by escherichia coli, we investigated whether it could be synthesised by h pylori. five h pylori isolates were collected from antral biopsy specimens from patients with g ... | 1990 | 2253906 |
| the efficacy of furazolidone and metronidazole in the treatment of chronic gastritis associated with helicobacter (campylobacter) pylori--a randomized double-blind placebo-controlled clinical trial. | seventy-two patients with helicobacter pylori-associated chronic gastritis were randomized to a 3-week oral treatment with furazolidone 0.1g t.i.d. or metronidazole 0.2g t.i.d. or placebo. endoscopy was performed before and after treatment, and biopsy specimens were taken from the antrum of the stomach for histological examination and culture of helicobacter pylori. disappearance rates of helicobacter pylori in furazolidone, metronidazole and the control groups were 74% (20/27) if considering co ... | 1990 | 2253927 |