Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| immunosuppression by junin virus. ultrastructural study. | 1974 | 4213176 | |
| junín virus. | 1974 | 4213994 | |
| ultrastructure of junín virus in mouse whole brain and mouse brain tissue cultures. | comparative ultrastructural studies were performed on the development of junín virus in mouse brain and in cerebellum explants and brain monolayers of the same animal. in mouse brain, neurons and astrocytes released virus particles by a budding mechanism identical to that previously described for this virus. in the neurons, the viral multiplication took place in the perikarion as well as in the cytoplasmic processes, including areas near synapses. viral particles were observed emerging from peri ... | 1974 | 4417948 |
| [protein synthesis and formation of junin virus in bhk cells]. | 1974 | 4424508 | |
| [analysis of factors conditioning plaque formation in vero cells infected with tacaribe and junin virus (fha)]. | 1974 | 4377464 | |
| nutritional requirements for junin virus production in bhk culture cells. | 1974 | 4377723 | |
| experimental biology and pathogenesis of junin virus infection in animals and man. | a fatal disease resembling argentine haemorrhagic fever of man has been produced in guinea-pigs and mice by inoculation with junin virus. infected guinea-pigs show macroscopic and microscopic haemorrhagic lesions, marked bone marrow changes, decreased leukocytes and platelets in the peripheral blood, and impairment of immunological response. this response permits differentiation between pathogenic (xj) and attenuated (xj cl(3)) strains. guinea-pigs inoculated with the xj cl(3) strain develop an ... | 1975 | 182401 |
| experimental biology and pathogenesis of junin virus infection in animals and man. | a fatal disease resembling argentine haemorrhagic fever of man has been produced in guinea-pigs and mice by inoculation with junin virus. infected guinea-pigs show macroscopic and microscopic haemorrhagic lesions, marked bone marrow changes, decreased leukocytes and platelets in the peripheral blood, and impairment of immunological response. this response permits differentiation between pathogenic (xj) and attenuated (xj cl(3)) strains. guinea-pigs inoculated with the xj cl(3) strain develop an ... | 1975 | 182401 |
| ultrastructural and immunohistochemical studies in five cases of argentine hemorrhagic fever. | ultrastructural and immunohistochemical studies on tissues from five patients with argentine hemorrhagic fever revealed previously undetected lesions caused by the viral infection. two types of particle were seen in the cells of all organs examined. the particles had some characteristics similar to those described for arenaviruses. however, the virus-like particles were intracellular, had a single membrane, and apparently originated by a process of budding into the endoplasmic reticulum cisterna ... | 1975 | 50390 |
| ultrastructural and immunohistochemical study of the human kidney in argentine haemorrhagic fever. | in six lethal cases of argentine haemorrhagic fever (ahf) a disease caused by junin virus, kidney samples were studied by means of immunofluorescent and electron microscopic techniques.--the ultrastructural studies showed that the distal and collecting tubes presented a large number of virus like intracytoplasmic particles. those particles were present in the lumen of the endoplasmic reticulum cisternae and showed two distinct morphological aspects. some of them were of high electron density and ... | 1975 | 171826 |
| [vertical transmission of junin virus in a closed colony of mice]. | 1975 | 175236 | |
| cross-protection between tacaribe complex viruses. presence of neutralizing antibodies against junin virus (argentine hemorrhagic fever) in guinea pigs infected with tacaribe virus. | cross-protection between junin virus and five other tacaribe complex viruses and the serological response of guinea pigs inoculated with tacaribe virus are reported here. previous infection with tamiami or pichinde viruses significantly delayed guinea pig deaths. a 58% survival rate was found among animals immunized with three doses of amapari virus, while guinea pigs inoculated with one dose of machupo or tacaribe virus were fully protected against junin virus. neutralization tests performed in ... | 1975 | 178627 |
| cross-protection between tacaribe complex viruses. presence of neutralizing antibodies against junin virus (argentine hemorrhagic fever) in guinea pigs infected with tacaribe virus. | cross-protection between junin virus and five other tacaribe complex viruses and the serological response of guinea pigs inoculated with tacaribe virus are reported here. previous infection with tamiami or pichinde viruses significantly delayed guinea pig deaths. a 58% survival rate was found among animals immunized with three doses of amapari virus, while guinea pigs inoculated with one dose of machupo or tacaribe virus were fully protected against junin virus. neutralization tests performed in ... | 1975 | 178627 |
| clinical and epidemiological patterns of argentine haemorrhagic fever. | the epidemiology of argentine haemorrhagic fever (ahf) is closely related to cricetine rodents acting as natural hosts of junin virus. the endemo-epidemic area, which has increased 5 times since the disease was first recognized 15-20 years ago, is located in a densely populated region of argentina. it has been shown that the virus of lcm is active in humans and rodents of the ahf endemic area; this demonstrates the simultaneous presence of two arenaviruses pathogenic for man in a given geographi ... | 1975 | 1085212 |
| clinical and epidemiological patterns of argentine haemorrhagic fever. | the epidemiology of argentine haemorrhagic fever (ahf) is closely related to cricetine rodents acting as natural hosts of junin virus. the endemo-epidemic area, which has increased 5 times since the disease was first recognized 15-20 years ago, is located in a densely populated region of argentina. it has been shown that the virus of lcm is active in humans and rodents of the ahf endemic area; this demonstrates the simultaneous presence of two arenaviruses pathogenic for man in a given geographi ... | 1975 | 1085212 |
| directions for future research on the pathogenesis of arenaviral infections. | the pathogenesis of arenavirus infection is considered separately for the haemorrhagic fever (hf) syndrome and for lymphocytic choriomeningitis (lcm) virus infection of rodents. experimental models of hf have received only limited study, mainly because of the virulence of the causal agents. two useful models (junin virus in guinea-pigs and machupo virus in rhesus monkeys) are now available and an attempt is made to delineate crucial questions for future studies, including the physiology of shock ... | 1975 | 1085229 |
| directions for future research on the pathogenesis of arenaviral infections. | the pathogenesis of arenavirus infection is considered separately for the haemorrhagic fever (hf) syndrome and for lymphocytic choriomeningitis (lcm) virus infection of rodents. experimental models of hf have received only limited study, mainly because of the virulence of the causal agents. two useful models (junin virus in guinea-pigs and machupo virus in rhesus monkeys) are now available and an attempt is made to delineate crucial questions for future studies, including the physiology of shock ... | 1975 | 1085229 |
| [editorial: ultrastructure of bone marrow and peripheral blood of guinea pigs infected with junin virus]. | 1975 | 1196119 | |
| [editorial: ultrastructure of bone marrow and peripheral blood of guinea pigs infected with junin virus]. | 1975 | 1196119 | |
| [experimental junin virus infection in the mouse: rototype of the disease]. | as previously postulated, the pathological changes which develop in 1-4 day old mice after intracerebral inoculation of 1-1000 dl50 of junín virus prototype strain (xj), was designated as experimental hemorrhagic fever of the mouse ehfm. in this paper, virus distribution, hematological alterations, interferon and circulating antibody responses are described. a mortality of 93.45% occurred between 9 and 20 days post-infection (p.i.), with 81.6% of death occurring between 11 and 18 days p.i. this ... | 1975 | 1208899 |
| passive immunity against junín virus in mice. | passive immunity, naturally acquired from immune mothers or artificially induced by the administration of homologous hyperimmune serum, conferred on suckling mice a high degree of resistance against infection with junín virus. maternal antibodies in the circulating blood of the young were not detectable in the first days after birth, but rised rapidly from the 8th to the 20th day of lactation. by cross-foster nursing experiments it was shown that the greater part of the transmission of passive i ... | 1975 | 239579 |
| further experiments on the action of antithymocyte serum in experimental junín virus infection. | rabbit anti-mouse thymocyte serum (ats) administrated as late as 7 days after infection suppressed host cell-mediated responsiveness to intracerebrally injected junín virus, thereby diminishing the morbility and mortality of this infection. it did not affect either the humoral antibody response or the virus titer in brain. this findings suggest that: a) in mouse brain cells, junín virus infection is basically non-cytopathic: b) cell-mediated immunity is responsible for morbility and mortality an ... | 1976 | 7942 |
| rna composition of junin virus. | junin virus grown in bhk-21 cells was labeled with [3h]uridine and highly purified by differential and isopycnic centrifugation. the rnas extracted with phenol and analyzed by polyacrylamide gel electrophoresis were shown to be composed of four large species (33, 28, and 18s) and three small ones (4, 5, and 5.5s). this pattern was similar to ones already reported for other arenaviruses. however, there was a striking difference when the virus labeling was performed in the presence of actinomycin ... | 1976 | 178925 |
| [subclinical infection, clinical infection and vaccination with junin virus]. | 1976 | 180380 | |
| [drugs inhibitory junin virus replication: glucoseamine, 2-deoxy-d-glucose and bis-benzimidazole]. | 1976 | 187895 | |
| [interference associated with cell cultures chronical by infected with the junin virus]. | supernatants from vero cells persistently infected with junin virus interfered with cytolitic and lethal activities of standard virus. two vero cell sublines, chronically infected with junin virus named vrj1 and vrj3, were obtained after prolonged cultivation of cells which survived primary infection. vfj1 was maintained over a period of 48 days, by biweekly serial transfers while vrj3, similarly treated, was cultivated for 385 days. one of the characteristics of these cell lines was resistance ... | 1976 | 188079 |
| [experimental junin virus infection of guinea pigs. i. pathological anatomy]. | 1976 | 966989 | |
| [experimental junin virus infection of guinea pigs. i. pathological anatomy]. | 1976 | 966989 | |
| junin virus structural proteins. | polyacrylamide gel electrophoresis of purified junin virus revealed six distinct structural polypeptides, two major and four minor ones. four of these polypeptides appeared to be covalently linked with carbohydrate. the molecular weights of the six proteins, estimated by coelectrophoresis with marker proteins, ranged from 25,000 to 91,000. one of the two major components (number 3) was identified as a nucleoprotein and had a molecular weight of 64,000. it was the most prominent protein and was n ... | 1977 | 189088 |
| junín virus infection of guinea pigs: electron microscopic studies of peripheral blood and bone marrow. | thin sections of peripheral white blood cells and samples of bone marrow from guinea pigs infected with junín virus were examined by electron microscopy. in peripheral blood cells, 40% of the granulocytes showed cytoplasmic lysis seven days after viral infection. after day 11 up to 80% of these cells showed morphological alterations. however, no intra- or extracellular viral particles were detected in these samples. microscopy of bone marrow preparations revealed that 10% of the cells were alter ... | 1977 | 191539 |
| junín virus infection of guinea pigs: electron microscopic studies of peripheral blood and bone marrow. | thin sections of peripheral white blood cells and samples of bone marrow from guinea pigs infected with junín virus were examined by electron microscopy. in peripheral blood cells, 40% of the granulocytes showed cytoplasmic lysis seven days after viral infection. after day 11 up to 80% of these cells showed morphological alterations. however, no intra- or extracellular viral particles were detected in these samples. microscopy of bone marrow preparations revealed that 10% of the cells were alter ... | 1977 | 191539 |
| a rapid method for detecting junin virus viremia in the guinea pig. | a method for detecting junin virus viremia in guinea pigs is described. the method consists of infecting bhk-21 cells with blood samples from infected guinea pigs; 48 h later, junin virus antigens are detected in the cells by indirect immunofluorescence. application of this technique to patients with argentine hemorrhagic fever may lead to the quickest method for the virologic diagnosis of this disease. | 1977 | 197047 |
| a rapid method for detecting junin virus viremia in the guinea pig. | a method for detecting junin virus viremia in guinea pigs is described. the method consists of infecting bhk-21 cells with blood samples from infected guinea pigs; 48 h later, junin virus antigens are detected in the cells by indirect immunofluorescence. application of this technique to patients with argentine hemorrhagic fever may lead to the quickest method for the virologic diagnosis of this disease. | 1977 | 197047 |
| [vero cells persistently infected with junin virus. ii. isolation of the virus]. | 1977 | 197369 | |
| [experimental infection of the guinea pig with junin virus. clinical picture, dissemination, and elimination of the virus]. | 1977 | 197371 | |
| [experimental infection of the guinea pig with junin virus. clinical picture, dissemination, and elimination of the virus]. | 1977 | 197371 | |
| [neurological complications of argentinian hemorrhagic fever]. | the argentine hemorrhagic fever (ahf) is an infectious disease, endemo-epidemical, of viral etiology, produced by the junin virus and limited to the buenos aires province, south of córdoba, east of la pampa, and south of santa fe. it generally assails rural workers at harvest-time, especially during corn-harvest. the incubation period of the disease does not exceed 12 days. a feverish syndrome with asthenia, adynamia, myalgias, migraine, photophobia, epigastralgia etc., appear. the patient has a ... | 1977 | 211453 |
| [cellular hypersensitivity in the infection of mice by junin virus. i. passive transfer]. | the data presented confirm previous evidence of delayed hypersensitivity in mice following infection with junin virus. adaptive transfer of sensitized cells from adult mice which had received 5 junin virus injections into preinfected newborn mice shortened their survival by 72 hours. it was clear, however, that the development of the immunological mechanism in adult mice occurred under certain conditions. this evidence was confirmed by the observations that the induction of cell-mediated immunit ... | 1977 | 208109 |
| [cellular hypersensitivity in the infection of mice by junin virus. iii. experience with cr51 an antitheta serum]. | several aspects of the appearance and development of delayed hypersensitivity in mice infected with junin virus are described. the results obtained showed that the development of the immunological mechanisms occurs irrespective of age. spleen cells of donor mice inoculated with one i.p. dose of junin virus had a poor cytotoxic activity, as demonstrated by 51cr release and adoptive immunity procedures. spleen cells treated with anti-theta serum and complement did not strikingly affect the develop ... | 1977 | 208110 |
| [in vitro interferon induction by junin virus; effect of pre-treatment with the inhibitor]. | 1977 | 561422 | |
| inapparent infections with junin virus among laboratory workers. | 1978 | 632626 | |
| viral haemorrhagic fevers of man. | this article reviews the current state of knowledge on the viral haemorrhagic fevers that infect man, namely smallpox, chikungunya fever, dengue fever, rift valley fever, yellow fever, crimean haemorrhagic fever, kyasanur forest disease, omsk haemorrhagic fever, argentinian haemorrhagic fever (junin virus), bolivian haemorrhagic fever (machupo virus), lassa fever, haemorrhagic fever with renal syndrome, and marburg and ebola virus diseases. | 1978 | 310725 |
| replication of dengue and junin viruses in cultured rabbit and human endothelial cells. | the flavivirus dengue and the arenavirus junin are both associated with a hemorrhagic shock syndrome in man. we have demonstrated the replication of these viruses in vitro in both rabbit and human endothelial cells by viral titers and immunofluorescent antibody studies. rabbit endothelium established in continuous culture was derived from vena cava, while human cells in primary culture were derived from umbilical veins. in rabbit endothelium, dengue-2 virus passaged through monkey kidney monolay ... | 1978 | 208980 |
| [heterologous immunization against junin virus. early protection]. | 1978 | 211366 | |
| studies of cell-mediated immunity to junín virus. | junín virus is uniformly lethal in newborn mice, but fails to kill adult animals. but there is direct evidence that in older mice the immunological mechanism occurs when certain conditions are fulfilled. the present results showed that in junín virus infection of mice, the development of the immunological mechanism occurs irrespectively of age. the induction of a regular cell-mediated immunity appears to be intimately related to multiple injections of the virus. these results were confirmed by t ... | 1978 | 25006 |
| [influence of the culture conditions on the regression of the cytopathogenic effect produced by junín virus in vero cells]. | 1978 | 231283 | |
| [congenital infection by junin virus in mice]. | 1978 | 216874 | |
| [callithrix jacchus infection with junin virus. new experimental model in argentinian hemorrhagic fever]. | 1978 | 216877 | |
| [callithrix jacchus infection with junin virus. new experimental model in argentinian hemorrhagic fever]. | 1978 | 216877 | |
| [infection of alouatta carayá (mono aullador) by junín virus]. | 1978 | 98811 | |
| [infection of alouatta carayá (mono aullador) by junín virus]. | 1978 | 98811 | |
| [infection of new world primates with junin virus. i. alouatta carayá]. | 1978 | 105225 | |
| [infection of new world primates with junin virus. i. alouatta carayá]. | 1978 | 105225 | |
| enhanced resistance against junin virus infection induced by corynebacterium parvum. | the effects of intraperitoneal administration of corynebacterium parvum on the course of junin virus infection in mice were investigated. this treatment produced enhanced resistance to the virus infection, evidenced by an increase in both survival times and the proportion of survivors. the protective effect was dependent upon the dose of c. parvum, and 280 mug/g of body weight was found to be the optimal dose. in various experiments, about 80% of the infected animals receiving this dose survived ... | 1978 | 205508 |
| studies of blood coagulation and pathology in experimental infection of guinea pigs with junin virus. | 1978 | 207791 | |
| studies of blood coagulation and pathology in experimental infection of guinea pigs with junin virus. | 1978 | 207791 | |
| argentine hemorrhagic fever. alterations of the complement system and anti-junin-virus humoral response. | we investigated immunologic mechanisms and the role of complement in the pathogenesis of argentine hemorrhagic fever, a disease caused by the junin virus, a member of the arenavirus group. total serum complement activity was reduced to 68 per cent of control values in patients with severe or moderate disease (p less than 0.001). c2, c3 and c5 values were also low (12 to 60 per cent) during the early acute period of the disease. however, serum c4 content was increased to 160 per cent of the contr ... | 1978 | 207985 |
| presence of viral particles in the salivary gland of calomys musculinus infected with junin virus by a natural route. | calomys musculinus, a wild cricetid rodent, is one of the main reservoirs of junin virus. six of these animals were infected by being placed in close contact with animals that had been experimentally infected with the virus. they were sacrificed at 10, 15 and 20 months after contact, and their salivary glands were studied by ultrastructural, immunohistochemical and virological methods. two animals developed chronic viremia and low titers of complement-fixing antibodies. these animals were the on ... | 1979 | 218895 |
| presence of viral particles in the salivary gland of calomys musculinus infected with junin virus by a natural route. | calomys musculinus, a wild cricetid rodent, is one of the main reservoirs of junin virus. six of these animals were infected by being placed in close contact with animals that had been experimentally infected with the virus. they were sacrificed at 10, 15 and 20 months after contact, and their salivary glands were studied by ultrastructural, immunohistochemical and virological methods. two animals developed chronic viremia and low titers of complement-fixing antibodies. these animals were the on ... | 1979 | 218895 |
| effect of glucosamine on the replication of the arenavirus junín in vero cells. | when vero cells infected with junín virus are cultured in the presence of 16 mm glucosamine, no infectious virus is produced and no surface antigens or virions are detected. cytoplasmic viral antigen, however, is synthesized normally. | 1979 | 218900 |
| temperature sensitivity of the arenavirus junin isolated from persistently infected vero cells. | a persistently infected cell culture was established from vero cells surviving primary infection with wild-type junin virus (jvwt). the cells were refractory to superinfection by both junin virus and the related tacaribe virus. replication of virus released from the persistently infected cells (jvpi) was inhibited at 39 degrees. jvpi did not interfere with jvwt at 37 degrees, and it was inactivated at 37, 40, 43, 46 and 50 degrees much more rapidly than was jvwt. | 1979 | 222707 |
| argentine hemorrhagic fever: a primate model. | experimental junin virus infection of a new world primate, callithrix jacchus, was evaluated. the virus produced anorexia, loss of weight, thrombocytopenia, leukopenia, and hemorrhagic and neurological symptoms and terminated in death. virus was recovered from urine, blood samples and all tissues taken at autopsy. these preliminary observations show that several aspects of the experimental disease in c. jacchus are quite similar to severe natural argentine hemorrhagic fever of man. | 1979 | 227811 |
| argentine hemorrhagic fever: a primate model. | experimental junin virus infection of a new world primate, callithrix jacchus, was evaluated. the virus produced anorexia, loss of weight, thrombocytopenia, leukopenia, and hemorrhagic and neurological symptoms and terminated in death. virus was recovered from urine, blood samples and all tissues taken at autopsy. these preliminary observations show that several aspects of the experimental disease in c. jacchus are quite similar to severe natural argentine hemorrhagic fever of man. | 1979 | 227811 |
| immunofluorescent anti-junin virus antibodies in argentine hemorrhagic fever. | immunofluorescent anti-junin virus antibodies were detected in 15 nonfatal cases of argentine hemorrhagic fever between the 2nd and 3rd week after onset of symptoms. in most cases, antibodies appeared by the day of clinical improvement, or between 2 and 4 days later. it was interesting to note that in 5 of 11 cases studied, the first positive serum sample presented anti-junin virus immunofluorescent antibodies in iga. in 2 of these 5 cases, iga was the only immunoglobulin with antibody activity ... | 1979 | 227813 |
| [infection of guinea pigs with an attenuated strain of junin virus xjcl3]. | 1979 | 232740 | |
| [infection of guinea pigs with an attenuated strain of junin virus xjcl3]. | 1979 | 232740 | |
| [a new biological marker for differentiating tacaribe and junin viruses: rk13 cells]. | 1979 | 502831 | |
| protection of guinea pigs inoculated with tacaribe virus against lethal doses of junin virus. | guinea pigs were protected against lethal doses of junin virus by a previous inoculation with tacaribe virus. fourteen guinea pigs were infected with 10(6) 50% lethal doses (ld50) of tacaribe virus and superinfected 45 days later with 10(3) ld50 of junin virus. appropriate control groups for both infections were also studied. the replication of junin virus was impaired, as no virus was isolated from blood and organs of animals killed on days 9 and 11 after infection. high levels of neutralizing ... | 1980 | 6245155 |
| protection of guinea pigs inoculated with tacaribe virus against lethal doses of junin virus. | guinea pigs were protected against lethal doses of junin virus by a previous inoculation with tacaribe virus. fourteen guinea pigs were infected with 10(6) 50% lethal doses (ld50) of tacaribe virus and superinfected 45 days later with 10(3) ld50 of junin virus. appropriate control groups for both infections were also studied. the replication of junin virus was impaired, as no virus was isolated from blood and organs of animals killed on days 9 and 11 after infection. high levels of neutralizing ... | 1980 | 6245155 |
| immunosuppression in experimental junin virus infection of mice. | the effects of cyclophosphamide (cy), anti-mouse thymocyte sera, oxisuran, and cytosine arabinoside were evaluated in adult and newborn mice infected with junin virus. treatment with cy was the most effective, adult mice, which are not normally susceptible to intracerebral infection with 10(3) ld50 of junin virus, were rendered susceptible by treatment with an adequate dose and schedule of cy. however, cy-treated newborn mice were protected from death. this animal model may be suitable for use i ... | 1980 | 6246026 |
| in vitro inactivation of complement by a serum factor present in junin-virus infected guinea-pigs. | a serum factor(s) of guinea-pigs infected with junin virus, the etiological agent of argentine haemorrhagic fever, is endowed with a potent anticomplementary activity. it is resistant to heat (56 degrees, 30 min) and elutes from a sephadex g-200 column between albumin and haemoglobin. it is ineffective in the presence of edta or egta and does not sediment at 82,000 g. it has no direct effect on c4 unless functional cl is present. however, it induces cl activation that consumes c4 haemolytic acti ... | 1980 | 6247264 |
| in vitro inactivation of complement by a serum factor present in junin-virus infected guinea-pigs. | a serum factor(s) of guinea-pigs infected with junin virus, the etiological agent of argentine haemorrhagic fever, is endowed with a potent anticomplementary activity. it is resistant to heat (56 degrees, 30 min) and elutes from a sephadex g-200 column between albumin and haemoglobin. it is ineffective in the presence of edta or egta and does not sediment at 82,000 g. it has no direct effect on c4 unless functional cl is present. however, it induces cl activation that consumes c4 haemolytic acti ... | 1980 | 6247264 |
| biological properties of junin virus proteins. i. identification of the immunogenic glycoprotein. | purified junin virus was disrupted by nonionic detergent treatment (triton x-100), and subviral components were separated by ultracentrifugation. only the soluble fraction, containing all of the major glycoprotein (mol.wt. 38,000), induced the formation of neutralizing antibodies in laboratory animals and protected them against subsequent challenge with live virus. thus, the glycoprotein is the antigen responsible for these immunologic responses. | 1980 | 6250990 |
| [antigenic capacity of junin virus inactivated by photodynamic oxidation]. | 1980 | 6251337 | |
| [infection of new world primates by junin virus. ii callithrix jacchus]. | 1980 | 6253762 | |
| [infection of new world primates by junin virus. ii callithrix jacchus]. | 1980 | 6253762 | |
| [effect of cyclophosphamide and antithymocyte serum on the resistance of the adult rat to junin virus]. | 1980 | 6253763 | |
| [preliminary study of an atenuated variant of junin virus derived from the xj prototype strain]. | 1980 | 6253764 | |
| [various aspects of experimental infection of the guinea pig with an attenuated variant of junin virus]. | 1980 | 6259493 | |
| [various aspects of experimental infection of the guinea pig with an attenuated variant of junin virus]. | 1980 | 6259493 | |
| [genesis of interferent particles during the multiplication of junin virus in vivo]. | 1980 | 6259494 | |
| serological survey to detect subclinical junín virus infection in laboratory personnel. | serological survey for detecting subclinical infections with junín virus, the etiological agent of argentine hemorrhage fever, was carried out in a group of 107 individuals working in laboratories where this virus was handled. the group was divided into high risk and low risk personnel according to the degree of exposure to the virus. neutralizing tests were performed in vero cell cultures to detect circulating antibodies. results were evaluated comparatively with those obtained in a previous su ... | 1980 | 6262457 |
| description of a bhk/21 cell line persistently infected with junin virus: its use in diagnostic procedures. | a bhk/21 cell line persistently infected by an arenavirus is described. during four consecutive passages, 30-45% of the cells showed granular cytoplasmic antigen by indirect immunofluorescence, employing both argentine hemorrhagic fever convalescent sera and sera from animals immunized with junin virus. virus isolated from the cells killed suckling mice but not adult mice and protected guinea pigs against further challenge with the virulent prototype strain of junin virus. neutralization tests s ... | 1980 | 6263820 |
| description of a bhk/21 cell line persistently infected with junin virus: its use in diagnostic procedures. | a bhk/21 cell line persistently infected by an arenavirus is described. during four consecutive passages, 30-45% of the cells showed granular cytoplasmic antigen by indirect immunofluorescence, employing both argentine hemorrhagic fever convalescent sera and sera from animals immunized with junin virus. virus isolated from the cells killed suckling mice but not adult mice and protected guinea pigs against further challenge with the virulent prototype strain of junin virus. neutralization tests s ... | 1980 | 6263820 |
| lymphatic tissue in argentine hemorrhagic fever. pathologic features. | spleen and lymph nodes from seven fatal cases of argentine hemorrhagic fever were studied by light and electron microscopy and by immunofluorescent techniques. in addition, junin virus infectivity was determined. destruction of splenic white pulp and of lymph node cortex was observed. the ultrastructural study showed a characteristic cytopathic effect on the macrophages with presence of intracisternal virus-like particles and occasional virions budding from the plasma membrane. the immunofluores ... | 1980 | 6154445 |
| biological activities of junin virus proteins. ii. complement-fixing polypeptides associated with the soluble antigen and purified virus particles. | in the junin virus-infected cell, there is a soluble antigen (sag), which we have detected by complement fixation. page of purified sag revealed two polypeptides with molecular weights of 20,000 and 25,000. an antigenically identical component, which was demonstrated by complement fixation and immunodiffusion tests and which had the same electrophoretic profile as sag, was found after proteolytic breakdown of purified virions. sag is an internal component of the virion, since it is unable to sti ... | 1980 | 6162824 |
| [persistent infection of mouse cells with junin virus: participation of interferon]. | 1980 | 6163063 | |
| [study of bone marrow in experimental argentine hemorrhagic fever. role of the megakaryocyte.] | in previous morphological studies on bone marrow of guinea pigs infected with junin virus, the coexistence of viral particles, antigens and cytopathic effects were observed in megakaryocytes. in addition, bone marrow is one of the organs where highest virus titers were obtained. however, although other myeloid cells presented intense cytopathic effect, viral antigens were observed only in reticular cells and virus particles were seen sporadically associated with immature cells. this study was de ... | 1980 | 22167697 |
| [study of bone marrow in experimental argentine hemorrhagic fever. role of the megakaryocyte.] | in previous morphological studies on bone marrow of guinea pigs infected with junin virus, the coexistence of viral particles, antigens and cytopathic effects were observed in megakaryocytes. in addition, bone marrow is one of the organs where highest virus titers were obtained. however, although other myeloid cells presented intense cytopathic effect, viral antigens were observed only in reticular cells and virus particles were seen sporadically associated with immature cells. this study was de ... | 1980 | 22167697 |
| induction of rna polymerase ii activity in junin virus-infected cells. | nuclear involvement of the host cell in junin virus (jv) replication was studied. alpha-amanitin was shown to inhibit jv yield, and rna synthesis in cell nuclei was found to be augmented during the eclipse period. jv infection exerted a selective effect on cellular rna polymerase activities, when measured in purified infected nuclei. rna polymerase i was inhibited, but rna polymerase ii was stimulated. these data support the hypothesis that rna polymerase ii is involved in arenavirus replication ... | 1981 | 6173349 |
| [interferon in experimental infection with junin virus]. | 1981 | 6178929 | |
| [a new plaque assay for the quantification of junin virus]. | 1981 | 6287522 | |
| [effect of experimental infection of pregnant guinea pigs with junin virus]. | 1981 | 6287523 | |
| [effect of experimental infection of pregnant guinea pigs with junin virus]. | 1981 | 6287523 | |
| diagnosis of junin virus in cell cultures by immunoperoxidase staining. | 1981 | 6277286 | |
| [congenital infection by junin virus in guinea pigs]. | 1981 | 7321861 | |
| [congenital infection by junin virus in guinea pigs]. | 1981 | 7321861 | |
| [properties of the interfering particles generated by junin virus in vero cells]. | 1981 | 6267411 | |
| [protection induced in guinea pigs by the variant xj0 of junin virus]. | 1981 | 6267412 | |
| [protection induced in guinea pigs by the variant xj0 of junin virus]. | 1981 | 6267412 |