Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| Recent advances in the molecular and cellular biology of bunyaviruses. | The family Bunyaviridae of segmented, negative-stranded RNA viruses includes over 350 members that infect a bewildering variety of animals and plants. Many of these bunyaviruses are the causative agents of serious disease in their respective hosts, and are classified as emerging viruses because of their increased incidence in new populations and geographical locations throughout the world. Emerging bunyaviruses, such as Crimean-Congo hemorrhagic fever virus, tomato spotted wilt virus and Rift Va ... | 2011 | 21865443 |
| inhibition of interferon induction and action by the nairovirus nairobi sheep disease virus/ganjam virus. | the nairoviruses are an important group of tick-borne viruses that includes pathogens of man (crimean congo hemorrhagic fever virus) and livestock animals (dugbe virus, nairobi sheep disease virus (nsdv)). nsdv is found in large parts of east africa and the indian subcontinent (where it is known as ganjam virus). we have investigated the ability of nsdv to antagonise the induction and actions of interferon. both pathogenic and apathogenic isolates could actively inhibit the induction of type 1 i ... | 2011 | 22163042 |
| tick cell lines for study of crimean-congo hemorrhagic fever virus and other arboviruses. | abstract continuous cell lines derived from many of the vectors of tick-borne arboviruses of medical and veterinary importance are now available. their role as tools in arbovirus research to date is reviewed and their potential application in studies of tick cell responses to virus infection is explored, by comparison with recent progress in understanding mosquito immunity to arbovirus infection. a preliminary study of propagation of the human pathogen crimean-congo hemorrhagic fever virus (cc ... | 2011 | 21955214 |
| crimean-congo hemorrhagic fever serosurvey in at-risk professionals, madagascar, 2008 and 2009. | crimean-congo hemorrhagic fever (cchf) is a zoonotic arboviral infection with hemorrhagic manifestation and often a fatal ending. human become infected mainly through tick bite or by crushing infected tick, by contact with blood or tissues from viraemic livestock or patient. cchf virus (cchfv) has been isolated once in madagascar but data on the epidemiology of the disease in the country are very scarce. | 2011 | 21889395 |
| re-emergence of crimean-congo hemorrhagic fever virus in central africa. | crimean-congo hemorrhagic fever (cchf) is a severe tick-borne disease well recognized through europe and asia where diagnostic tests and medical surveillance are available. however, it is largely neglected in africa, especially in the tropical rainforest of central africa where only sporadic human cases have been reported and date back to more than 30 years. we describe here an isolated human case that occurred in the democratic republic of the congo in 2008 and performed phylogenetic analysis t ... | 2011 | 22022629 |
| identification of a putative crimean-congo hemorrhagic fever virus entry factor. | entry of enveloped viruses into cells is initiated by binding of their envelope glycoproteins (envs) to cell surface-associated receptors. the crimean-congo hemorrhagic fever virus (cchfv) has two envs, gn and gc, with poorly understood role in binding to susceptible cells. we expressed codon optimized gn and gc, and identified independently folded soluble env fragments, one of which (gc residues 180-300) bound cchfv susceptible cells supposedly by interacting with a putative receptor. this rece ... | 2011 | 21723257 |
| epidemiological survey of crimean-congo hemorrhagic fever virus in yunnan, china, 2008. | objectives: we aimed to determine the seroprevalence of crimean-congo hemorrhagic fever virus (cchfv) infection in yunnan province, china. materials and methods: one thousand six hundred and fifty-seven human serum samples and 1280 ticks (hyalomma asiaticum) were collected from five counties (menglian, menghai, lancang, mengla, and ximeng). serum samples were analyzed independently by indirect immunofluorescence assay and western blotting to detected cchfv antibody. the ticks were examined by re ... | 2011 | 21546303 |
| crimean-congo hemorrhagic fever: current and future prospects of vaccines and therapies. | crimean-congo hemorrhagic fever (cchf) is a tick-borne disease caused by cchf virus (cchfv), a nairovirus in the family bunyaviridae. cchf occurs sporadically in a number of countries in asia, the middle east, southeastern europe and africa. patients may develop subclinical to severe hemorrhagic disease, with fatal outcomes in a substantial percentage of cases. transmission usually occurs through contact with viremic livestock or patients or bites by infected ticks. the number of reported cases ... | 2011 | 21362441 |
| molecular basis for ubiquitin and isg15 cross-reactivity in viral ovarian tumor domains. | crimean congo hemorrhagic fever virus (cchfv) is a deadly human pathogen that evades innate immune responses by efficiently interfering with antiviral signaling pathways mediated by nf-?b, irf3, and ifna/ß. these pathways rely on protein ubiquitination for their activation, and one outcome is the modification of proteins with the ubiquitin (ub)-like modifier interferon-stimulated gene (isg)15. cchfv and related viruses encode a deubiquitinase (dub) of the ovarian tumor (otu) family, which unlike ... | 2011 | 21266548 |
| structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease. | the attachment of ubiquitin (ub) and the ub-like (ubl) molecule interferon-stimulated gene 15 (isg15) to cellular proteins mediates important innate antiviral responses. ovarian tumor (otu) domain proteases from nairoviruses and arteriviruses were recently found to remove these molecules from host proteins, which inhibits ub and isg15-dependent antiviral pathways. this contrasts with the ub-specific activity of known eukaryotic otu-domain proteases. here we describe crystal structures of a viral ... | 2011 | 21245344 |
| Hazara virus infection is lethal for adult type I interferon receptor-knockout mice and may act as a surrogate for infection with the human pathogenic Crimean-Congo Haemorrhagic Fever virus. | Hazara virus (HAZV) is closely related to Crimean-Congo Haemorrhagic Fever virus (CCHFV). HAZV has not been reported to cause human disease; work with infectious material can be carried out at containment level (CL)-2. By contrast, CCHFV causes a haemorrhagic fever in humans and requires CL-4 facilities. A disease model of HAZV infection in mice deficient in the type I interferon receptor is reported in this study. Dose response effects were seen, with higher doses resulting in a shorter time to ... | 2011 | 22090213 |
| seroepidemiological study of crimean-congo haemorrhagic fever in greece, 2009-2010. | clin microbiol infect abstract: to estimate endemic areas for crimean-congo haemorrhagic fever (cchf) in greece, a country-wide seroepidemiological study was conducted, and 1611 human sera were prospectively collected along with data regarding possible risk factors for acquisition of infection, and tested for cchf virus igg antibodies by elisa. the overall seroprevalence was 4.2%, with significant differences among prefectures, ranging from 0 to 27.5%. multivariate analysis revealed that slaught ... | 2011 | 22192082 |
| Bacterial expression of Crimean-Congo hemorrhagic fever virus nucleoprotein and its evaluation as a diagnostic reagent in an indirect ELISA. | Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne viral zoonosis distributed widely in Africa, Asia, Russia and the Balkans. The emergence and re-emergence of CCHFV emphasize the importance of increasing both human and veterinary surveillance and developing diagnostic capacity. Recombinant CCHFV nucleocapsid protein (NP) has been expressed using insect cells and mammalian cells and used as a diagnostic tool but bacterial expression has not been described previously. The S gene of CCH ... | 2012 | 22001274 |
| possible drivers of crimean-congo hemorrhagic fever virus transmission in kosova. | abstract crimean-congo hemorrhagic fever (cchf) has long been a disease of concern in kosova; however, little is known about the enzootic cycles of the virus in this country. since the first documented case in 1954, sporadic cases and occasional outbreaks have been recorded with cases more consistently reported following the conflict in 1999. cchf virus exists in enzootic cycles between wild animal species and ticks. the infection rates within ticks and hence the exposure to humans is determin ... | 2012 | 22217174 |
| detection, isolation and confirmation of crimean-congo hemorrhagic fever virus in human, ticks and animals in ahmadabad, india, 2010-2011. | in january 2011, human cases with hemorrhagic manifestations in the hospital staff were reported from a tertiary care hospital in ahmadabad, india. this paper reports a detailed epidemiological investigation of nosocomial outbreak from the affected area of ahmadabad, gujarat, india. | 2012 | 22616022 |
| tick-borne viruses in europe. | the aim of this review is to present briefly background information on 27 tick-borne viruses ("tiboviruses") that have been detected in europe, viz flaviviruses tick-borne encephalitis (tbev), louping-ill (liv), tyuleniy (tyuv), and meaban (meav); orthobunyaviruses bahig (bahv) and matruh (mtrv); phleboviruses grand arbaud (gav), ponteves (ptvv), uukuniemi (uukv), zaliv terpeniya (ztv), and st. abb's head (sahv); nairoviruses soldado (solv), puffin island (piv), avalon (avav), clo mor (cmv), cri ... | 2012 | 22526290 |
| development of a real-time rt-pcr assay for the detection of crimean-congo hemorrhagic fever virus. | abstract crimean-congo hemorrhagic fever (cchf) is a virulent tick-borne disease with a case fatality rate ranging from 10-50% for tick-borne transmission, and up to 80% for nosocomial transmission. human cases have been reported in over 30 countries across europe, asia, and africa. it appears to be spreading to new areas with several countries reporting their first human cases of cchf disease within the past 10 years. we report a novel real-time rt-pcr assay designed to amplify a conserved re ... | 2012 | 22217175 |
| molecular detection of crimean-congo haemorrhagic fever virus in ticks collected from infested livestock populations in a new endemic area, south of iran. | crimean-congo haemorrhagic fever (cchf) is a viral zoonotic disease with potentially fatal systemic effects on man. we aimed to determine the presence of cchf virus among collected ticks from domestic livestock from october 2012 to september 2013. | 2016 | 26758985 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |