Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| suppression of hepatitis c virus rna by interferon-alpha. | 1990 | 1973789 | |
| infectivity of blood that is immunoblot intermediate reactive on hepatitis c virus antibody testing. | 1990 | 1973990 | |
| screening donors for hepatitis c virus antibody. | 1990 | 1973991 | |
| detection of hepatitis c virus rna in serum. | 1990 | 1973992 | |
| alanine aminotransferase screening and hepatitis c virus antibody. | 1990 | 1974981 | |
| hepatitis c virus rna in symptomless donors implicated in post-transfusion non-a, non-b hepatitis. | 1990 | 1974982 | |
| hepatitis c virus transmitted by human bite. | 1990 | 1975005 | |
| antibody to hepatitis c virus in hungary. the hungarian multicenter hcv study group. | 1990 | 1975309 | |
| hepatitis c quantification and sequencing in blood products, haemophiliacs, and drug users. | the polymerase chain reaction (pcr) detected specific hepatitis c viral (hcv) rna sequences in plasma from 15 of 21 haemophiliacs (12 hcv-antibody positive) and 7 of 27 intravenous drug users (13 hcv-antibody positive). quantification of rna-positive samples showed high levels of hcv (10(5) to 10(6) copies of rna/ml) in infected patients. hcv was more frequently found in haemophiliacs infected with human immunodeficiency virus (11/11 hiv-positive and 4/10 hiv-negative patients). hcv-rna was dete ... | 1990 | 1979093 |
| comparison of the replication of distinct strains of human coronavirus oc43 in organotypic human colon cells (caco-2) and mouse intestine. | three strains of human coronavirus (hcv) oc43 were compared for their ability to cause enteric infections and to induce interferon alpha (ifn alpha) using the caco-2 human colon carcinoma cell line which exhibits spontaneous epithelial differentiation in vitro. mrc-5 cell culture grown stocks were prepared from: 1. cv paris, a strain of oc43 recovered from an outbreak of necrotizing enterocolitis in newborns. 2. cv mb, a neurotropic strain of oc43 which exhibits strict neuronal specificity in mu ... | 1990 | 2103102 |
| molecular characterization of the 229e strain of human coronavirus. | human coronaviruses (hcv) cause various respiratory, gastrointestinal and possibly neurological disorders. very little is known of the molecular biology of these ubiquitous pathogens. we have undertaken the molecular characterization of the prototype 229e strain of hcv. the virus grew to the highest titers on a human embryonic lung cell line (l132) at 33 degrees c and purification was optimal on renografin-60 gradients. metabolic labeling with [35s]methionine or [3h]glucosamine or galactose and ... | 1990 | 2103105 |
| epidemiology of hepatitis c virus. a preliminary study in volunteer blood donors. | in a survey carried out from 1985 through 1986, volunteer blood donors to the greater new york blood program were tested for two surrogate markers for non-a, non-b hepatitis--elevation of alanine aminotransferase level and presence of antibody to hepatitis b core antigen. stored serum samples from selected donors were also recently tested for antibody to hepatitis c virus (anti-hcv). anti-hcv was detected in 0.9% to 1.4% of donors and was higher in black and hispanic donors than in white donors. ... | 1990 | 2104548 |
| non-a, non-b hepatitis and antibody to hepatitis c virus. | stored serum samples from the transfusion-transmitted viruses study in the 1970s were tested for the presence of antibody to hepatitis c virus (anti-hcv). single specimens from five control subjects who did not receive transfusions tested negative for anti-hcv. of four control subjects who did not receive transfusions and who developed non-a, non-b (nanb) hepatitis after hospitalization, three remained anti-hcv negative; the fourth person with postoperative nanb hepatitis tested anti-hcv positiv ... | 1990 | 2104549 |
| detection of antibody against antigen expressed by molecularly cloned hepatitis c virus cdna: application to diagnosis and blood screening for posttransfusion hepatitis. | a cdna clone has been derived from the plasma of a chimpanzee with chronic non-a, non-b viral hepatitis (nanbh). we have assayed for antibodies reacting with the encoded antigen in sera from posttransfusion hepatitis patients (643 samples from 23 patients) and their corresponding donors collected during the past 10 years in japan. the antibody was detected in 15 out of 17 (88.2%) posttransfusion nanbh (pt-nanbh) patients whose sera over time displayed multiple alanine aminotransferase (alt) peak ... | 1990 | 2105505 |
| [hepatitis c virus (hcv), anti-hcv and non-a, non-b hepatitis]. | our data on 559 serum samples are discussed in the light of the present knowledge on hepatitis c virus (hcv). this newly discovered virus is thought to be the main cause of the bloodborne non-a, non-b hepatitis. hcv is a single-stranded, encapsulated rns virus. presently one antibody, anti-hcv, is detectable, which is directed against a nonstructural viral component. this antibody appears only weeks to months after infection or onset of the disease. within 6-9 months 60-80% of the patients with ... | 1990 | 2106158 |
| high prevalence of antibody to hepatitis c virus in multitransfused hemophiliacs with normal transaminase levels. | 1990 | 2106281 | |
| [blood transfusion and hepatitis: hepatitis c virus detection]. | 1990 | 2106428 | |
| anti-hepatitis c virus antibody prevails in fulminant hepatic failure. | serial serum samples obtained from 27 patients with fulminant hepatic failure (fhf) in a variety of etiology were tested for anti-hepatitis c virus antibody (anti-hcv). seven out of 10 patients (70%) with fhf due to hepatitis b virus (hbv) infection were positive for anti-hcv, showing a significantly higher rate than that in acute hbv hepatitis (0/17, 0%): in particular, all 3 post-transfusion hbv-fhf cases were found to be positive for the antibody. the incidence of anti-hcv in sporadic non-a n ... | 1990 | 2106465 |
| hepatitis c virus: a giant leap forward. | 1990 | 2106475 | |
| long-term follow-up of posttransfusion and sporadic chronic hepatitis non-a, non-b and frequency of circulating antibodies to hepatitis c virus (hcv). | the natural course of chronic hepatitis non-a, non-b (hnanb) was documented for 3-20 yr (mean 8 yr) in 86 patients, who attended our special ambulance between 1981 and 1988. sixty five of the 86 patients (75%) were positive for circulating antibodies against hepatitis c virus (hcv) (anti-hcv). twenty four patients had chronic posttransfusion (pt)-hnanb (18 anti-hcv-positive; 75%), and 62 patients had sporadic (s)-hnanb (47 anti-hcv-positive; 75%). twenty nine per cent of patients with chronic pt ... | 1990 | 2106548 |
| [from non-a non-b hepatitis to hepatitis c virus]. | 1990 | 2107109 | |
| [hepatitis c virus: a discovery of molecular biology]. | 1990 | 2107110 | |
| correlation of hepatitis c virus antibodies with hiv-1 seropositivity in intravenous drug addicts. | 1990 | 2110117 | |
| hepatitis c virus infection in patients with nonalcoholic chronic liver disease. | to determine the prevalence and meaning of antibodies to the hepatitis c virus (hcv) in patients with nonalcoholic chronic liver diseases. | 1990 | 2111108 |
| the prevalence of hepatitis c virus antibodies among hemodialysis patients. | 1990 | 2111110 | |
| mother to infant transmission of hepatitis c virus infection. | eight women with chronic hepatitis c virus (hcv) infection during pregnancy gave birth to 11 children. five of these children had elevated alt, but only two had increased levels in more than one sample. all children tested before 6 months of age were positive for anti-hcv at most up to 7 months of age and then became negative. one child with a maximum alt level of 8.4 mukat/l however, regained anti-hcv positivity at 12 months of age, and a liver biopsy at 21 months of age showed resolving hepati ... | 1990 | 2111372 |
| the serology of hepatitis c virus in relation to post-transfusion hepatitis. | natural history studies conducted over the past 15 years have shown that parenterally transmitted non-a non-b hepatitis infection frequently results in an indolent chronic disease with serious long-term consequences. the recent identification of nucleic acid sequences comprising the genome of hepatitis c virus (hcv) has allowed the development of a serological assay based upon recombinant viral proteins specifically associated with the major agent of non-a, non-b hepatitis infection. the hcv ant ... | 1990 | 2111652 |
| antibodies to hepatitis c virus in non-a non-b fulminant viral hepatitis. | 1990 | 2112102 | |
| screening of blood donations for hepatitis c virus antibody. | 1990 | 2112223 | |
| blood screening for non-a, non-b hepatitis by hepatitis c virus antibody assay. | hepatitis c virus (hcv) antibody was detected in 1499 donor sera by radioimmunoassay using an antigen expressed in yeast from a cdna clone of the hcv genome. eighteen samples over 4200 counts per minute (cpm) were considered to contain infectious hcv because these recipients developed typical posttransfusion non-a, non-b hepatitis after transfusion. the antibody-positive sera were all within the normal range of alt levels. this assay system is thus useful for the screening for blood transfusion. | 1990 | 2112278 |
| anti-hepatitis c virus in blood donors with raised alt levels. | 1990 | 2112281 | |
| low risk for hepatitis c in hemophiliacs given a high-purity, pasteurized factor viii concentrate. international study group. | to assess whether the hepatitis b virus (hbv), the hepatitis c virus (hcv), and the human immunodeficiency virus (hiv) are transmitted to hemophiliacs by a high-purity factor viii concentrate in which the method of virus inactivation is pasteurization. | 1990 | 2112352 |
| prevalence of anti-hcv in patients on long-term hemodialysis. | the prevalence of hepatitis c virus (hcv) infection in patients with long-term hemodialysis (hd) in japan was assessed using an ortho hcv antibody elisa test system. out of 51 patients, 48 of whom had a history of blood transfusions, 15 (29%) were positive for anti-hcv. this figure is much higher than that in other countries (1-20%), and the difference may reflect a select population. six (33%) of 18 hd patients with chronic hepatic disease were anti-hcv positive. on the other hand, the prevalen ... | 1990 | 2113144 |
| antibody to hepatitis c virus in risk groups in canada. | 1990 | 2113437 | |
| detection of hepatitis c virus genomes from patient's plasma using pcr method. | 1990 | 2113500 | |
| nucleotide sequences and subtypes of hepatitis c virus genomes. | 1990 | 2113501 | |
| prevalence of hepatitis c virus antibody in a cohort of hemophilia patients. | one hundred thirty-one patients followed at the new england hemophilia center (worcester, ma) were tested for antibody to hepatitis c virus (hcv). all but two had used factor concentrate that had not undergone viral inactivation; two patients had used only cryoprecipitate. the overall prevalence of hcv antibody positivity was 76.3%. there was no significant difference in age or the amount of non-heat-treated factor concentrate used between the group that was hcv antibody positive and negative. t ... | 1990 | 2114186 |
| [hepatitis virus c: from discovery to applications in public health]. | after 15 years of unsuccessful efforts, the most frequent of hepatitis non-a non-b viruses has just been identified and called hepatitis c virus (hcv). the viral genome had been sequenced by an original and direct molecular biology method before the agent could be detected serologically or at electron microscopy. hcv is a small, encapsulated rna virus, perhaps loosely related to flaviviruses. a non-structural protein, corresponding to the virus replication enzyme, is the specific component as ta ... | 1990 | 2115200 |
| [non-a non-b acute hepatitis]. | two distinct forms of non a non b viral hepatitis are now distinguished: (a) parenterally transmitted non a non b hepatitis, mainly due to hepatitis c virus, (b) enterically transmitted non a non b hepatitis, mainly due to hepatitis e virus. hepatitis c virus is an enveloped, 50 to 60 nm in diameter, single stranded rna virus. its transmission is essentially parenteral and resembles that of hepatitis b virus. individuals at risk are those in contact with blood products. sexual transmission is un ... | 1990 | 2115201 |
| [transmission of viruses (from a to e) and prevention]. | recent advances in epidemiology, virology and molecular biology have made it possible: 1) to isolate and characterize the hepatitis c and d viruses (and soon the virus of hepatitis e); 2) to develop vaccines against hepatitis a and recombinant vaccines against hepatitis b; and 3) to obtain a better understanding of the modes of transmission of the viruses and, consequently, to devise and offer an efficient prophylaxis. | 1990 | 2115202 |
| [acute viral hepatitis in children]. | in children with acute hepatitis the main concern is to identify the cause since prognosis and therefore management largely depend on the specific causative agent. since hav is the most frequent in children, it should be investigated first. if there are no igm anti-hav antibodies, hepatitis b should be investigated. the value of anti-hcv antibodies, during acute hepatitis is not clear. whatever the virus, severe evolution may occur, and symptoms of poor significance must be detected early. there ... | 1990 | 2115203 |
| hepatitis c virus in patients with cryoglobulinemia type ii. | 1990 | 2115556 | |
| hepatitis c virus: the major causative agent of viral non-a, non-b hepatitis. | a 'blind' recombinant immunoscreening approach, of general application to studies of infectious diseases, was used to clone and identify the genome of the previously uncharacterized non-a, non-b hepatitis (nanb) virus. this agent is a positive-stranded rna virus that appears to be distantly related to the flaviviridae family. a recombinant viral antigen (c100-3) was used to develop a capture assay for circulating antibody. data obtained using this assay indicate that this agent, termed the hepat ... | 1990 | 2116212 |
| fulminant viral hepatitis. | in the united kingdom and united states of america, fulminant viral hepatitis is due mainly to sporadic (non-parenteral) non-a, non-b hepatitis and hepatitis b whereas that caused by hepatitis a virus is very uncommon and by the herpes viruses remains rare. recent advances in fulminant non-a, non-b hepatitis have come with the identification and cloning of a virus (27-34 nm) in the enteral variety (hepatitis e) which is prevalent in the indian sub-continent, north africa and elsewhere, especiall ... | 1990 | 2116214 |
| transmission of hepatitis c virus. | 1990 | 2116749 | |
| early events in hepatitis c virus infection of chimpanzees. | the cytoplasmic antigen and ultrastructural changes we described previously for chimpanzees (pan troglodytes) infected with hepatitis c virus (hcv) or with hepatitis d virus have recently been shown to be indirect measures of viral replication and appear to represent a host response to the expression or action of interferon. the time of appearance of these changes in hepatocytes during hcv infection, when compared with similar changes in hepatitis d virus infection, suggests a very early replica ... | 1990 | 2117282 |
| is hepatitis c virus involved in hepatitis-associated aplastic anemia? | to determine whether hepatitis c virus is involved in hepatitis-associated aplastic anemia. | 1990 | 2117412 |
| nucleotide sequence of core and envelope genes of the hepatitis c virus genome derived directly from human healthy carriers. | 1990 | 2117749 | |
| there are two major types of hepatitis c virus in japan. | the polymerase chain reaction (pcr) was used to detect hepatitis c virus (hcv) in plasma from chronic non-a, non-b hepatitis patients. by choice of adequate primers, 19 of 24 samples (79%) were found positive. sequence analysis of amplified 400 bp cdna fragments encoding a portion of ns5 gene suggested that hcv can be classified into two types (named k1 and k2) in japan. slot blot hybridization of the fragments indicated that 13 were hcv-k1 and 6 were hcv-k2, which show 80% and 67% nucleotide se ... | 1990 | 2117923 |
| the new hepatitis virus: hepatitis c virus. | 1990 | 2118223 | |
| aids and hepatitis b and c: contamination risk at transurethral resection. a study using sodium fluorescein as a marker. | the human immunodeficiency virus (hiv), hepatitis b virus (hbv) and hepatitis c virus (hcv) are all transmitted by minute amounts of infected blood. surgeons are at risk of contracting these infections by a number of routes including splashes of blood on to the mucous membranes of eyes, nose and mouth, needle stick injuries and spillage of blood on chapped ungloved hands. the endoscopic surgeon is quite unaware of nearly all instances of facial contamination because the splashes are frequently b ... | 1990 | 2118224 |
| does hepatitis c virus play a role in "non-viral" chronic liver disease? | it has recently been suggested that the hepatitis c virus may play a significant role in chronic liver diseases, such as autoimmune chronic active hepatitis, which are usually attributed to non-viral causes. we tested for antibodies to hepatitis c virus (anti-hcv) in sera from 140 patients with well characterised "non-viral" chronic liver diseases as well as sera from 51 patients thought to have chronic non-a, non-b (nanb) hepatitis (acting as positive controls) and 25 patients with non-hepatic ... | 1990 | 2118225 |
| epidemiology and hepatitis c virus in victoria. | parenterally transmitted non-a, non-b (nanb) hepatitis virus or hepatitis c virus is a common cause of both acute and chronic hepatitis. using a recently developed enzyme-linked immunosorbent assay we looked at the prevalence of antibodies to hepatis c virus (anti-hcv) in a number of groups. people with haemophilia (75.6%) and intravenous drug users (61.9%) had the highest prevalence, while homosexual men attending a sauna (34.1%) and prisoners (30.8%) had a moderately high prevalence of anti-hc ... | 1990 | 2118226 |
| hepatitis c virus in intravenous drug users. | sera from 172 intravenous drug users were tested for the presence of antibodies to hepatitis c virus (anti-hcv). the results were analysed in relation to aspects of the history of drug use and evidence of liver disease. the presence of anti-hcv was strongly associated with duration of intravenous drug use. two-thirds of patients were anti-hcv seropositive within two years of commencing regular intravenous drug use, and there was 100% seropositivity among people injecting drugs for more than eigh ... | 1990 | 2118227 |
| hepatitis c virus in italian drug addicts. | 1990 | 2118318 | |
| hepatitis c virus antibodies in parasitic infections. | 1990 | 2118319 | |
| sexual transmission of hepatitis c virus: cohort study (1981-9) among european homosexual men. | to determine the prevalence, incidence, and persistence of positivity for antibodies to hepatitis c virus (anti-hcv) and the potential for sexual transmission of the virus. | 1990 | 2118402 |
| [incidence of anti-hcv and alt in blood donors]. | a study was carried out in 2,000 blood donors aimed to assess the incidence of anti-c hepatitis virus antibodies. of the total number of samples, 10 cases were found positive (0.5%), a figure lower than the national average. of these 10 cases, alt levels were high in 5 (0.2%). the potential risk of post-transfusion c hepatitis increases in accordance with the number of blood units transfused. this incidence of anti-c hepatitis virus antibodies is discussed with regard to previous findings in oth ... | 1990 | 2118686 |
| prevalence of hepatitis c virus antibodies in italian blood donors. the italian cooperative group. | 11,117 blood donors from 24 blood transfusion services evenly distributed throughout the various italian regions were tested for the presence of hepatitis c virus (hcv) antibodies in the serum and serum alanine aminotransferase (alt) level. the results are as follows: (1) anti-hcv seroprevalence in italy was 0.87% with a difference between northern and southern regions (0.68 vs. 1.37%) and between younger and older subjects (0.62 vs. 1.21%); (2) prevalence of elevated alt levels was 4.74% withou ... | 1990 | 2118697 |
| is the response to recombinant alpha interferon related to the presence of antibodies to hepatitis c virus in patients with chronic non-a, non-b hepatitis? | the purpose of this study was to determine whether the response of serum alanine aminotransferase (alt) to recombinant alpha-interferon was related to the presence or absence of antibodies to hepatitis c virus (anti-hcv) in patients with chronic non-a,non-b hepatitis. a group of 65 patients with chronic non-a, non-b hepatitis was studied. the source of contamination was blood transfusion or administration of blood products in 32, intravenous drug addiction in 14 and unknown in 19. the patients r ... | 1990 | 2118928 |
| antibody to hepatitis c virus in multiply transfused patients with thalassaemia major. | seventeen of 73 (23.3%) multiply transfused patients with thalassaemia major (age range, 1-39 years) tested positive for antibody to hepatitis c virus (anti-hcv). eleven of the 24 patients regularly transfused in countries outside britain were anti-hcv seropositive; only six of the 49 regularly transfused in britain were seropositive. the incidence of anti-hbs and anti-hbc was similar to that of anti-hcv in both the british and foreign patients. the anti-hcv seropositive patients showed signific ... | 1990 | 2119395 |
| prevalence, incidence, and risk factors of hepatitis c virus infection among drug users in amsterdam. | the prevalence, risk factors, and incidence of hepatitis c virus (hcv) infection were studied in a cohort of drug users in amsterdam. in intravenous drug users, the seroprevalence was 74% (224/304) versus 10% (4/42) in nonintravenous drug users. risk factors independently associated with hcv antibody seropositivity were history and duration of intravenous drug use and frequency of injections. daily smoking of heroin in the previous 6 months was independently associated with the absence of hcv an ... | 1990 | 2119400 |
| hepatitis c infection in two urban hemodialysis units. | we determined the prevalence of antibodies to the hepatitis c virus (anti-hcv) in 90 patients and 37 staff members of two hemodialysis units utilizing a recently developed anti-hcv recombinant based assay. eleven patients (12%) were anti-hcv(+). of these, eight (73%) had antibodies to the hepatitis b core antigen (anti-hbc) indicating prior hepatitis b infection; one patient was hepatitis b surface antigen (hbsag)(+). all staff members were anti-hcv(-), although seven (19%) of them were anti-hbc ... | 1990 | 2119469 |
| antibodies to hepatitis c virus in japanese blood donors and in hospital personnel. | 1990 | 2119534 | |
| viral hepatitis. the new abc's. | hepatitis may be caused by hepatitis a virus, hepatitis b virus, hepatitis c virus (classic non-a non-b viral hepatitis), hepatitis d virus (delta agent), and hepatitis e virus (epidemic non-a non-b viral hepatitis). cytomegalovirus, epstein-barr virus, and herpes simplex virus may also occasionally cause hepatitis. some forms of hepatitis carry the risks of chronic infection, cirrhosis, or hepatocellular carcinoma. treatment options for viral hepatitis are limited and, in many cases, still unde ... | 1990 | 2120686 |
| [hepatitis c virus infection in patients treated with hemodialysis]. | the prevalence of hepatitis c infection was evaluated (ortho hcv antibody elisa test) in 64 patients with chronic renal failure treated in a single hemodialysis unit. none of these patients was a carrier of hepatitis b virus nor of antibodies against human immunodeficiency virus. antibodies against hepatitis c virus were detected in 11 patients (17%). the prevalence was higher in the 13 previously diagnosed of non a, non b hepatitis (77%) than in the 51 without previous hepatitis (2%) (p less th ... | 1990 | 2123506 |
| [recent acquisitions on viral hepatitis]. | in the last years the research on viral hepatitis let to better understand the biological, molecular, immunological and epidemiologic characteristics of the viruses that are responsible for hepatitis. the first studied virus was hepatitis b virus (hbv). the scientific attention is still, today, focused on that virus since new markers of infectivity and biological importance in early diagnosis and in disease evolution have been found. the most important result in the last years in the field of vi ... | 1990 | 2125720 |
| [long-term treatment of cryptogenic hepatitis c using recombinant interferon alpha]. | in a pilot study 15 patients with cryptogenic chronic hepatitis non-a, non-b received human recombinant interferon alpha (rifna) at a dosage of 5 million units 3 times per week for periods of up to 4 months, followed by an additional 4-month course of treatment with 2 million units 3 times per week after an observed reduction in serum aminotransferase levels. ten of the 15 patients demonstrated antibodies to hepatitis c virus (hcv). pretreatment histological examinations revealed evidence of chr ... | 1990 | 2125776 |
| treatment of chronic viral hepatitis anno 1990. | alpha-interferon has emerged as the most effective agent for the treatment of chronic hepatitis when active replication of virus b, c, or d is present. exogenous administration of human alpha-interferon, now possible through modern large-scale production methods, is associated with suppression of virus in blood. amelioration of liver disease occurs in 35% of patients with hepatitis b virus and in 50% with hepatitis c virus with interferon doses of 30 and 10 mu per week, respectively, for 16-26 w ... | 1990 | 2126146 |
| hepatitis c antibody in a non-hemophiliac cohort infected with the human immunodeficiency virus. | development of a serologic test which detects antibody to hepatitis c virus (anti-hcv) allowed us to compare the seroprevalence of hepatitis c and hepatitis b in 493 persons infected with the human immunodeficiency virus (hiv). these persons, none of whom are hemophiliacs, are part of the us air force hiv natural history study. we found that hepatitis b core antibody (anti-hbc) was far more prevalent (59%) than anti-hcv (8%). anti-hbc prevalence was not different between those with and those wit ... | 1990 | 2127529 |
| hepatitis c virus infection in individuals with or without human immunodeficiency virus type 1 infection. | serum specimens from 111 human immunodeficiency virus type 1 (hiv-1) infected and 183 hiv-1 seronegative patients were analysed for antibodies to hepatitis c virus (hcv), hepatitis b virus (hbv) and hepatitis a virus (hav) by enzyme linked immunoassay (elisa) and radioimmunoassay. anti-hcv and anti-hbv antibodies were found in the vast majority (89 and 83%, respectively) of intravenous drug addicts (ivda), independent of the type of drug abuse or whether the patients were hiv-1 infected or not. ... | 1990 | 2127586 |
| a randomized, double-blind, placebo-controlled trial of recombinant human alpha-interferon therapy for chronic non-a, non-b (type c) hepatitis. | the effects of alpha-interferon therapy were evaluated in a prospective, randomized, double-blind, controlled trial of recombinant human interferon alfa-2b versus placebo in patients with well-documented chronic non-a, non-b hepatitis (type c). forty-one patients, of whom 37 (90%) had hepatitis c virus antibodies in their serum, were enrolled in the trial. twenty-one patients received interferon (2 million units) and 20 received placebo as subcutaneous injections three times weekly for 6 months. ... | 1990 | 2127786 |
| recombinant human interferon alfa-2a in community-acquired non-a, non-b chronic active hepatitis. preliminary results of a randomized, controlled trial. | a randomized, controlled trial was undertaken to evaluate the response to recombinant interferon alfa-2a in patients with hepatitis b surface antigen negative chronic active hepatitis of unknown aetiology (community-acquired non-a, non-b hepatitis). thirty patients were treated with thrice weekly interferon in a dose of 6 million units for 1 month, followed by 3 million units for 3 months and 1 million units maintenance therapy for 8 months. patients who relapsed were returned to the previously ... | 1990 | 2127791 |
| recombinant gamma-interferon as adjuvant to hepatitis b vaccine in hemodialysis patients. | patients undergoing long-term hemodialysis are at high risk of acquiring hepatitis b yet tend to have poor rates of response to hepatitis b vaccine. the effect of recombinant human gamma-interferon (2 million units/m2) on the response to a recombinant hepatitis b vaccine was evaluated in a prospective, randomized controlled trial in 81 hemodialysis patients. a similar proportion of both groups of vaccinees ultimately developed antibody to hbsag including 81% of the 41 recipients of vaccine alone ... | 1990 | 2145212 |
| high frequency of antibodies to the hepatitis c virus among patients with hepatocellular carcinoma. | 1990 | 2153357 | |
| [recent advances on hepatitis c virus research]. | 1990 | 2154632 | |
| [isolation of a cdna clone derived from variant type of hepatitis c virus]. | 1990 | 2154633 | |
| [separation of hepatitis c virus (hcv) genome and its application for diagnosis of hcv infection]. | 1990 | 2154634 | |
| [hepatitis c virus and its pathogenicity]. | 1990 | 2154637 | |
| hepatitis c virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. | hepatitis c virus (hcv) is an important human pathogen that is associated with transfusion-related non-a, non-b hepatitis. recently, hcv cdna was cloned and the nucleotide sequence of approximately three-quarters of the virus genome was determined. a region of the predicted polyprotein sequence was found to share similarity with a nonstructural protein encoded by dengue virus, a member of the flavivirus family. we report here that hcv shares an even greater degree of protein sequence similarity ... | 1990 | 2156259 |
| [testing for hepatitis c]. | over the past 10 years, 12,146 cases of hepatitis were diagnosed in the virology department of vienna university. 30.3% were hepatitis a, 39.2% hepatitis b, 3.0% cytomegalovirus and 1.5% epstein-barr virus infections. the remaining 25.8% were diagnosed as non-a, non-b hepatitis (nanb). therefrom, a sample of 167 sera from acute and 78 from chronic hepatitis nanb were tested for hepatitis c. 9.6% of the acute and 44.9% of the chronic cases were positive. we conclude from these data that about 12% ... | 1990 | 2156382 |
| hepatitis c. | the major cause of chronic post-transfusion hepatitis, the hepatitis c virus (hcv), has been identified. hcv is a single-stranded linear rna virus with characteristics similar to the flaviviruses. a different agent, the hepatitis e virus, is associated with epidemic (enterically-transmitted) non-a, non-b hepatitis. at present, infection with hcv is recognized by the finding of anti-hcv antibodies, positive in up to 90% of patients with chronic non-a, non-b post-transfusion hepatitis. antibodies ... | 1990 | 2159711 |
| [hepatitis c virus and hepatocellular carcinoma]. | 1990 | 2159872 | |
| [infection with hepatitis viruses hav, hbv and hcv as well as with aids virus hiv in drug addicts of the zurich street scene--a prevalence study]. | 382 i.v. drug abusers were tested for a past or ongoing infection with the hepatitis viruses a (hav), b (hbv), the newly discovered c (hcv) and with the aids virus hiv. the cohort studied was representative for i.v. drug users of the zurich street scene including occasional users, weekend users and severe drug addicts. 56% of the drug users tested showed hbv markers. 21% had an ongoing infection. 32% were naturally hbv immune and 4% showed immunity due to vaccination. hav markers were detected i ... | 1990 | 2160123 |
| serum antibodies to hepatitis c virus in italian patients with hepatocellular carcinoma. | antibodies against hepatitis c virus (anti-hcv) were detected in 60.8% of 78 patients with hepatocellular carcinoma (hcc). cirrhosis, present in most of the patients, as well as alcohol abuse, age, sex, and alpha-fetoprotein were equally distributed in the anti-hcv-positive and -negative groups. hbsag positivity was significatively higher in negative anti-hcv group. by contrast, hepatitis b virus (hbv) antibodies were detected more frequently in positive anti-hcv patients than in the negative an ... | 1990 | 2160517 |
| prevalence of hepatitis b and c viral markers in black and white patients with hepatocellular carcinoma in the united states. | the recent cloning of the genome of a non-a, non-b hepatitis agent, designated the hepatitis c virus (hcv), has led to the development of an immunoassay for circulating hcv antibodies (anti-hcv). we used this immunoassay to investigate the possible association between hcv infection and hepatocellular carcinoma in black and white residents of los angeles county, california. serum samples from 51 patients (12 black and 39 white) in los angeles county with hepatocellular carcinoma and 128 control s ... | 1990 | 2161463 |
| hepatocellular carcinoma associated with chronic viral hepatitis. aetiology, diagnosis and treatment. | two major aetiological factors have been definitively incriminated in the pathogenesis of hcc: these are chronic hepatitis and hepatic cirrhosis. chronic infection with hepatotropic viruses may account for the majority of cases of hepatocellular carcinoma in high incidence areas, and a varying prevalence of human hepatitis b and hepatitis c virus infection appears to determine the differing geographical prevalence of hepatocellular carcinoma in high and low incidence areas of the world. patients ... | 1990 | 2165844 |
| hepatitis c virus and transfusion transmitted liver disease: review. | 1990 | 2166092 | |
| hepatitis c virus infection is associated with the development of hepatocellular carcinoma. | a possible causative role for the recently discovered hepatitis c virus (hcv) in the development of hepatocellular carcinoma (hcc) was investigated by assay of sera from hcc patients in japan for antibodies to a recombinant hcv antigen and to hepatitis b virus (hbv) antigens. among the 253 hcc patients examined, 156 (61.7%) had no serum markers of either a previous or a current hbv infection (group i), 46 (18.2%) were negative for hbv surface antigen but positive for anti-hbv surface and/or anti ... | 1990 | 2168552 |
| allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. | loss of heterozygosity on chromosome 16 is a common genetic alteration in human hepatocellular carcinoma (hcc). to clarify the pathogenetic significance of allele loss on chromosome 16, we performed restriction fragment length polymorphism analysis of 70 surgically resected tumors by using 15 polymorphic dna markers for chromosome 16. loss of heterozygosity on chromosome 16 was detected in 36 (52%) of 69 informative cases, and the common region of allele loss in these 36 tumors was located betwe ... | 1990 | 2168560 |
| prevalence of antibody against non-a, non-b hepatitis virus in japanese patients with hepatocellular carcinoma. | antibodies against a possible causative agent of non-a, non-b hepatitis, hepatitis c virus (hcv), in japanese patients with hepatocellular carcinoma were analyzed using the enzyme-linked immunosorbent assay (elisa) system from ortho diagnostic systems, japan. fifty of 58 cases of hepatitis b virus surface antigen (hbsag)-negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of hbsag-positive hepatocellular carcinoma were positive (19%). among patients with hbsa ... | 1990 | 2169469 |
| hepatitis c virus infection in an area hyperendemic for hepatitis b and chronic liver disease: the taiwan experience. | to assess the contribution of hepatitis c virus (hcv) in liver disease in taiwan, antibody to hcv (anti-hcv) was studied by radioimmunoassay in 392 patients with chronic liver disease and in 440 healthy adults and 444 subjects at risk. the anti-hcv prevalence was 0.95% in 420 volunteer blood donors, 90% in 100 hemophiliacs, and 81% in 58 parenteral drug abusers. anti-hcv was present in 6 (7.7%) of 78 hepatitis b surface antigen (hbsag)-positive and 28 (65%) of 43 hbsag-negative patients with chr ... | 1990 | 2169497 |
| the 5'-terminal sequence of the hepatitis c virus genome. | the 5'-terminal sequence of the genome of hepatitis c virus (hcv) was determined for two distinct hcv strains in human and chimpanzee carriers. it had a 5'-noncoding region of at least 324 nucleotides, well preserved by the two strains with a high homology (99.1%), followed by 1348 nucleotides that continued to the documented sequence of prototype hcv spanning 7310 nucleotides (european patent application #88310922.5). based on these results, hcv is considered to possess an uninterrupted open re ... | 1990 | 2170712 |
| susceptibility of laboratory mice to intranasal and contact infection with coronaviruses of other species. | the susceptibility of laboratory mice to intranasal and contact infection with mouse hepatitis virus (mhv)-related coronaviruses was tested in infant cd1 mice. one day old mouse pups were inoculated intranasally with respiratory mhv-s, enteric mhv-y, rat sialodacryoadenitis virus (sdav), human coronavirus oc43 (hcv-oc43) or bovine coronavirus (bcv). twenty-four hours later, they were placed in direct contact with age matched sham inoculated pups. indices of infection in virus inoculated mice inc ... | 1990 | 2170746 |
| association of autoimmune hepatitis with hla-bw54 and dr4 in japanese patients. | human leukocyte antigen-d region-related alleles (human leukocyte antigen dr and dq) and human leukocyte antigen class i alleles were typed serologically in 31 japanese patients with autoimmune hepatitis. these patients had increased serum levels of ast and igg, high titers of autoantibodies, no history of blood transfusion and were negative for hbsag and antibodies to hbc. three hundred eighty-six healthy subjects and 30 patients with cryptogenic chronic hepatitis served as control groups. the ... | 1990 | 2175292 |
| molecular cloning of the human hepatitis c virus genome from japanese patients with non-a, non-b hepatitis. | the nucleotide sequence of the japanese type of hepatitis c virus (hcv-j) genome, consisting of 9413 nucleotides, was determined by analyses of cdna clones from plasma specimens from japanese patients with chronic hepatitis. hcv-j genome contains a long open reading frame that can encode a sequence of 3010 amino acid residues. comparison of hcv-j with the american isolate of hcv showed 22.6% difference in nucleotide sequence and 15.1% difference in amino acid sequence. thus hcv-j and the america ... | 1990 | 2175903 |
| the putative nucleocapsid and envelope protein genes of hepatitis c virus determined by comparison of the nucleotide sequences of two isolates derived from an experimentally infected chimpanzee and healthy human carriers. | cdna fragments of a 5'-terminal region of the hepatitis c virus (hcv) genome were isolated by the reverse polymerase chain reaction from rna extracted from plasma samples of healthy japanese carriers. their nucleotide sequence was compared with that of the original isolate which had been passaged twice in chimpanzees. no deletions or insertions were observed between the two sequences in the regions examined. both the 5' untranslated and putative nucleocapsid (core) protein regions were highly co ... | 1990 | 2177094 |
| hepatitis a, b, c, d and e viruses: structure of their genomes and general properties. | hepatitis a virus is an enteric picornavirus. its genome is a single stranded rna molecule of positive-strand polarity of 7478 bases. this sequence codes for a polyprotein which is processed to give rise to viral proteins vp-1, vp-2, vp-3 and others. hepatitis b virus, a major worldwide infectious and cancer promoting agent contains a dna genome of 3226 base pairs that replicates by a reverse transcriptase via an rna intermediate. extensive sequencing and expression experiments have revealed fou ... | 1990 | 2227269 |
| human immunodeficiency virus (hiv) infection, sexually transmitted diseases and hiv-antibody testing practices in belgian prostitutes. | from december 1988 to april 1989, 154 female prostitutes in and around ghent, belgium, were interviewed about their knowledge, attitudes and practices in relation to the risks for sexually transmitted diseases (std) and human immunodeficiency virus (hiv) infection in their profession. thirty four women worked as window prostitutes, 120 picked up their clients in bars, clubs, and saunas. blood samples were taken from 123 women. one (0.8%) was seropositive for hiv1, 19 (15.4%) had hepatitis b core ... | 1990 | 2245981 |
| nucleotide sequence of the gene encoding the spike glycoprotein of human coronavirus hcv 229e. | the gene encoding the spike glycoprotein of the human coronavirus hcv 229e has been cloned and sequenced. this analysis predicts an s polypeptide of 1173 amino acids with an mr of 128,600. the polypeptide has 30 potential n-glycosylation sites. a number of structural features typical of coronavirus s proteins can be recognized, including a signal sequence, a membrane anchor, heptad repeat structures and a carboxy-terminal cysteine cluster. a detailed, computer-aided comparison with the s protein ... | 1990 | 2345367 |