Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| immunoassay reagents for thyroid testing. 2. binding properties and energetic parameters of a t4 monoclonal antibody and its fab fragment with a library of thyroxine analog biosensors using surface plasmon resonance. | a library of 16 thyroxine analog biosensors were prepared for use on the biacore surface plasmon resonance instrument. an anti-thyroxine monoclonal antibody and its fab fragment were tested with each biosensor to generate the association and dissociation rate constants, equilibrium association constants, and gibbs free energy values for characterizing the binding event. | 1997 | 9095353 |
| [a case report on successful coronary artery bypass grafting (cabg) for angina pectoris combined with hypothyroidism]. | coronary artery bypass grafting (cabg) for patients with ischemic heart disease and hypothyroidism contains many controversies, such as a need of preoperative thyroid replacement therapy and the influences on thyroid function and hemodynamics. a 73-year-old man with three vessel disease including left main trunk lesion was admitted for cabg. primary hypothyroidism was diagnosed after admission because of high cpk value. the cabg was performed safely with preoperative minimal thyroid replacement ... | 1997 | 9095585 |
| protein hinge bending as seen in molecular dynamics simulations of native and m61 mutant t4 lysozymes. | a dynamical model of interdomain "hinge bending" of t4 lysozyme in aqueous solution has been developed on the basis of molecular dynamics (md) simulation. the md model study provides a description of the conformational reorganization expected to occur for the protein in aqueous solution as compared to the crystalline environment. three different 500 ps molecular dynamics simulations were calculated, each using a distinctly different crystal conformation of t4 lysozyme as the starting points of t ... | 1997 | 9095676 |
| inhibition of holliday structure resolving endonuclease vii of bacteriophage t4 by recombination enzymes uvsx and uvsy. | proteins uvsx, uvsy and endonuclease vii (endo vii) of bacteriophage t4 are required for dna recombination, replication and repair. endo vii is the product of gene 49 (gp49) and essential for resolution of branches from newly made dna, prior to packaging into preformed heads. the ability of endo vii to resolve holliday structures in vitro suggested an in vivo function for the resolution of recombination intermediates, generated by uvsx and uvsy during the early infection cycle. here we report re ... | 1997 | 9096214 |
| the genome of the pseudo t-even bacteriophages, a diverse group that resembles t4. | polymerase chain reaction analysis of a large collection of bacteriophages with t-even morphology revealed four phages that are distantly related to all the others. the genomes of these pseudo t-even phages hybridized under stringent conditions to only a limited portion of the t4 genome that encodes virus head, head-to-tail joining and contractile tail genes. except for this region, no extensive hybridization was detected between most pairs of the different pseudo t-even genomes. sequencing of t ... | 1997 | 9096222 |
| appendix carcinoma invading the urinary bladder. | we report a case of an appendix carcinoma invading the urinary bladder. in contrast to other bowel tumors invading the bladder, history and symptoms were consistent with a primary bladder tumor. this is due to the unique anatomical position of the appendix where the tumor did not hinder passage of bowel contents or cause melena. findings on physical examination as well as diagnostic imaging and transurethral resection were inconclusive. consideration of local progression of an appendix carcinoma ... | 1997 | 9096277 |
| dimethoate inhibits extrathyroidal 5'-monodeiodination of thyroxine to 3,3',5-triiodothyronine in mice: the possible involvement of the lipid peroxidative process. | the effects of daily administration of dimethoate (2, 4 and 8 mg/kg body weight for 30 days) on thyroid function in mice were investigated. while serum triiodothyronine (t3) concentration was decreased significantly, serum thyroxine (t4) was increased in the medium and highest dose treated groups. however, the serum concentration of thyrotropin was unaltered. hepatic type-i iodothyronine 5'-monodeiodinase (5'-d) enzyme activity was depressed by the two higher doses of dimethoate. these observati ... | 1997 | 9096279 |
| a direct comparison of helix propensity in proteins and peptides. | alpha-helical secondary structure occurs widely in globular proteins and its formation is a key step in their folding. as a consequence, understanding the energetics of helix formation is crucial to understanding protein folding and stability. we have measured the helix propensities of the nonpolar amino acids for an alpha-helix in an intact protein, ribonuclease t1, and for a 17-residue peptide with a sequence identical to that of the alpha-helix in the protein. the helix propensities are in ex ... | 1997 | 9096306 |
| prognostic factors for clinically localized prostate carcinoma: analysis of 938 patients irradiated in the prostate specific antigen era. | pretreatment serum prostate specific antigen (psa) level is a powerful prognostic factor for clinically localized prostate carcinoma. the traditional prognostic factors, t classification and gleason score, appear to have been relegated to a minor position. this study was conducted to evaluate the relative prognostic roles of psa, t classification, and gleason score in a large cohort of men irradiated in the psa era. | 1997 | 9083160 |
| density functional calculations on model tyrosyl radicals. | a gradient-corrected density functional theory approach (pwp86) has been applied, together with large basis sets (iglo-iii), to investigate the structure and hyperfine properties of model tyrosyl free radicals. in nature, these radicals are observed in, e.g., the charge transfer pathways in photosystem ii (psii) and in ribonucleotide reductases (rnrs). by comparing spin density distributions and proton hyperfine couplings with experimental data, it is confirmed that the tyrosyl radicals present ... | 1997 | 9083661 |
| endoscopic ultrasonography for assessment of the response to combined radiation therapy and chemotherapy in patients with esophageal cancer. | measuring the response of esophageal cancer to combined chemotherapy and radiotherapy is difficult. initial results using ultrasonography have been contradictory. the purpose of this study was to correlate the endoscopic ultrasonography (eus) findings after preoperative chemoradiotherapy with the histology of the resected specimens, and to assess the accuracy of eus in predicting the response to treatment. | 1997 | 9083729 |
| extended resection for locally advanced colorectal carcinoma. | the purpose of this study was to determine the therapeutic benefit of multivisceral resection (mvr) in patients with locally advanced colorectal carcinomas. | 1997 | 9084849 |
| pneumocystis carinii pneumonia. review of 32 cases in immunocompromised hosts. | the records of patients in whom pneumocystis carinii pneumonia (pcp) was diagnosed between january 1989 and december 1991 were reviewed. thirty-two patients--all immunocompromised--were included in the study: 41% were hiv-positive and 59% hiv-negative. in 23 patients (72%) concomitant pathogens were isolated, most frequently cytomegalovirus. presenting symptoms included fever (97%), cough (75%) and dyspnea (63%). all hiv-infected patients had a t4-lymphocyte count below 200/mm3 (or 20%). the maj ... | 1997 | 9085615 |
| rna-dna hybrid formation at a bacteriophage t4 replication origin. | the bacteriophage t4 replication origins ori(uvsy) and ori(34) each contain two distinct components: a t4 middle-mode promoter that is strictly required for replication and a downstream region of about 50 bp that is required for maximal levels of replication. here, we present evidence that structure of the downstream region is important for replication initiation. based on sensitivity to a single-stranded dna-specific nuclease in vitro the downstream region behaves as a dna unwinding element. th ... | 1997 | 9086270 |
| single-stranded dna binding properties of the uvsy recombination protein of bacteriophage t4. | the uvsy protein is an essential component of the bacteriophage t4 general recombination machinery. the properties of this 16 kda protein include selective binding to ssdna, as well as specific protein-protein interactions with other t4 recombination proteins including uvsx (general recombinase) and gp32 (ssdna-binding protein). uvsy promotes the assembly of uvsx-ssdna filaments, the active species in uvsx-catalyzed dna rearrangements, apparently by helping uvsx displace gp32 from the ssdna. to ... | 1997 | 9086271 |
| maternal thyroid function does not alter maternal serum alpha-fetoprotein interpretation. | endocrine alterations of metabolism such as diabetes and obesity are known to affect maternal serum alpha-fetoprotein interpretation. thyroid function has been questioned, e.g., because of binding globulins, but not adequately studied as to its impact upon maternal serum alpha-fetoprotein. the purpose of this study was to assess the possible effects of t4 and thyroid-stimulating hormone (tsh) on alpha-fetoprotein production, and to determine if thyroid function (hypothyroidism) alters maternal s ... | 1997 | 9086429 |
| phenotype differences of resistance to thyroid hormone in two unrelated families with an identical mutation in the thyroid hormone receptor beta gene (r320c). | a new family with resistance to thyroid hormone (rth) harboring a mutation in the thyroid hormone receptor (tr) beta gene (r320c) is reported. the phenotype of affected members is compared to that of affected members of an unrelated family with an identical mutation in the tr beta gene that occurred independently. in one of the two families higher concentrations of free t4 were required to maintain a normal tsh level in affected subjects and unaffected first degree relatives but not in relatives ... | 1997 | 9086567 |
| transiently decreased sialylation of thyrotropin (tsh) in a patient with the euthyroid sick syndrome. | a 60-year old woman was admitted to the medical intensive care unit with respiratory distress and worsening renal function, and was found to have bilateral renal artery occlusion. aggressive nutrition per nasogastric tube was begun on day 8 of her illness, and she eventually recovered after bilateral renal artery bypass surgery, which was performed on day 15. she developed the euthyroid sick syndrome. levels of serum tsh, t3, and t4 fell during the first few days of her illness, then all trended ... | 1997 | 9086572 |
| maternal diabetes mellitus, a rat model for nonthyroidal illness: correction of hypothyroxinemia with thyroxine treatment does not improve fetal thyroid hormone status. | maintenance of normal maternal thyroxinemia prevents severe triiodothyronine (t3) deficiency of the fetus with primary thyroid failure (1). we have studied whether thyroxine (t4) would also protect the fetal brain when maternal hypothyroxinemia is caused by nonthyroidal illnesses. we have used the streptozotocin-induced diabetes mellitus pregnant rat as a model of maternal nonthyroidal illness. we measured the effects of diabetes mellitus, and of correction of the ensuing maternal hypothyroxinem ... | 1997 | 9086576 |
| intracellular protein transport to the thyrocyte plasma membrane: potential implications for thyroid physiology. | we present a snapshot of developments in epithelial biology that may prove helpful in understanding cellular aspects of the machinery designed for the synthesis of thyroid hormones on the thyroglobulin precursor. the functional unit of the thyroid gland is the follicle, delimited by a monolayer of thyrocytes. like the cells of most simple epithelia, thyrocytes exhibit specialization of the cell surface that confronts two different extracellular environments-apical and basolateral, which are sepa ... | 1997 | 9086577 |
| thyroid hormone in neural rescue. | serum thyroxine (t4), triiodothyronine (t3), and reverse triiodothyronine (rt3) were followed for 24 h in dogs resuscitated following 9 min of controlled cardiac arrest (ca). total t4, free t4, total t3, and free t3 decreased, while reverse t3 was elevated in the 24 h following resuscitation. similar changes occurred with only 30 sec of ca. levothyroxine sodium (l-t4) post-ca (7.5 micrograms/kg/h = ca + 7.5 or 15 micrograms/kg/h = ca + 15) increased total t4, free t4, and total t3. free t3 decre ... | 1997 | 9086579 |
| thyroid hormone-regulated actin polymerization in brain. | thyroid hormones play an important role in the growth and development of the brain. central to the proper integration of neuronal circuitry is the ability of the growing neurite to interpret guidance cues during its migration. the action cytoskeleton is especially rich in the growth cone, and is a likely target for thyroid hormone regulation. this brief review summarizes work showing that thyroxine, but not t3, dynamically regulates the polymerization of the actin cytoskeleton in astrocytes. the ... | 1997 | 9086583 |
| multiple conformational states of the bacteriophage t4 capsid surface lattice induced when expansion occurs without prior cleavage. | the maturation pathway of bacteriophage t4 capsid provides a model system for the study of largescale conformational changes, in that the precursor capsid progresses through four long-lived and widely differing states. the surface lattice first assembled (uncleaved/unexpanded state: hexagonal lattice constant, a = 11.8 nm) undergoes proteolytic cleavage (cleaved/unexpanded state), then expands (cleaved/ expanded state: a = 14.0 nm), and then binds accessory proteins. the most profound change, ex ... | 1997 | 9087916 |
| the palliative therapy of advanced prostate cancer, with particular reference to the results of recent european clinical trials. | the palliative therapy of advanced prostate cancer still remains a perplexing problem. if advanced prostate cancer is defined either as a primary advanced-stage tumour (t3, t4, n0-n1), or a rising psa level after primary and hopefully curative therapy, or the traditional patient presenting with small- or large-volume metastases with or without symptoms, then some 60% of all patients have advanced disease when first seen. there is still a need for the continuation of large prospective, randomized ... | 1997 | 9088277 |
| biomechanical effects of transthoracic microdiscectomy. | nondestructive flexibility testing was performed to quantify biomechanical parameters of human cadaveric thoracic spines before and after microdiscectomy. | 1997 | 9089932 |
| cancer of the nasal cavity and paranasal sinuses. a clinico-pathological study of 277 patients. | in the period 1963-1991, a total of 277 consecutive patients with malignant tumours of the nasal cavity and paranasal sinuses were treated at aarhus university hospital. the major histological types included squamous cell carcinoma (46%), lymphoma (14%), adenocarcinoma (13%), and malignant melanoma (9%). kaplan-meier estimates of 5-year corrected survival (death from cancer) showed the best prognosis for adenoid cystic carcinoma (87%), adenocarcinoma (65%) and lymphoma (56%), and the poorest pro ... | 1997 | 9090965 |
| bone scintigraphy in the canine cruciate deficiency model of osteoarthritis. comparison of the unstable and contralateral knee. | to examine the effects on 99mtc medronate (mdp) bone scintigraphy of unilateral anterior cruciate ligament (acl) transection in the unstable and contralateral knee of dogs. | 1997 | 9002025 |
| cloning and expression of a 5'-iodothyronine deiodinase from the liver of fundulus heteroclitus. | recent molecular cloning studies in mammals and amphibians have demonstrated that the types i, ii, and iii deiodinases constitute a family of selenoproteins of critical importance in metabolizing t4 to active (i.e. t3) and inactive (i.e. rt3) metabolites. in several tissues of teleost fish, various deiodinase processes have been described, but the structural and functional characteristics of these enzymes and their relationship to the deiodinases present in higher vertebrates remains uncertain. ... | 1997 | 9002998 |
| thyroid hormone-induced expression of specific somatostatin receptor subtypes correlates with involution of the ttt-97 murine thyrotrope tumor. | following the protracted hypothyroid state, treatment with thyroid hormone will induce a decline in tsh and reduce thyrotrope hyperplasia. somatostatin is a hypothalamic peptide that has been implicated in the negative regulation of tsh secretion in the thyrotrope. moreover, analogs of native somatostatin have potent tsh-reducing and growth-retarding effects on human thyrotropinomas. the ttt-97 tumor is an in vivo murine thyrotropic model that has retained its physiological response to thyroid h ... | 1997 | 9003007 |
| thyroid hormones regulate the onset of osmotic activity of rat liver mitochondria after birth. | the effect of thyroid hormone deprivation on the osmotic activity of liver mitochondria from early newborn rats was studied. experimentally induced hypothyroidism prevented the increase in the osmotic activity of mitochondria observed immediately after birth. osmotic activity was restored by t4 and t3 treatment to hypothyroid newborns but not when this treatment was supplemented with cycloheximide. under the same circumstances, streptomycin had no effect. hypothyroidism abolished the change in t ... | 1997 | 9003013 |
| evidence for circadian variations of thyroid hormone concentrations and type ii 5'-iodothyronine deiodinase activity in the rat central nervous system. | the 24-h patterns of tissue thyroid hormone concentrations and type ii 5'- and type iii 5-iodothyronine deiodinase (5'd-ii and 5d-iii, respectively) activities were determined at 4-h intervals in different brain regions of male euthyroid rats entrained to a regular 12-h light/12-h dark cycle (lights on at 6:00 a.m.). activity of 5'd-ii, which catalyzes the intracellular conversion of thyroxine (t4) to 3,3',5-triiodo-l-thyronine (t3) in the cns, and the tissue concentrations of both t4 and t3 exh ... | 1997 | 9003071 |
| conformation of t4 lysozyme in solution. hinge-bending motion and the substrate-induced conformational transition studied by site-directed spin labeling. | t4 lysozyme and mutants thereof crystallize in different conformations that are related to each other by a bend about a hinge in the molecule. this observation suggests that the wild type protein may undergo a hinge-bending motion in solution to allow substrate access to an otherwise closed active site cleft [faber, h.r., & matthews, b.w. (1990) nature 348, 263-266]. to test this hypothesis, either single or pairs of nitroxide side chains were introduced into the protein to monitor tertiary cont ... | 1997 | 9003182 |
| functional and sequence analysis of splicing defective nrdb mutants of bacteriophage t4 reveal new bases and a new sub-domain required for group i intron self-splicing. | the nrdb gene of bacteriophage t4 codes for the small subunit of ribonucleotide reductase and contains a 598 nuclelotide group 1 self splicing intron. in order to study the functional domains for self-splicing of this intron, 23 nrdb splicing defective intron mutants were analyzed for both sequence and functional changes. these mutants cluster towards the ends in regions of conserved structural elements of the intron. these 23 mutants have single base changes at 14 different sites. interestingly ... | 1997 | 9003462 |
| transforming growth factor beta as a clinical biomarker for prostate cancer. | tumor biomarkers to detect prostate cancer earlier may reduce prostate cancer deaths. transforming growth factor-beta1 and -beta2 (tgf-beta1 and -beta2) become overexpressed in prostate cancer and might be useful tumor markers of prostate cancer. | 1997 | 9000208 |
| thoracic esophageal carcinoma: evaluation in the sagittal section with magnetic resonance imaging. | among 54 patients with thoracic esophageal carcinoma (53 squamous cell carcinoma, 1 adenosquamous carcinoma), the usefulness of mr sagittal imaging for evaluating local extent (t factor) was examined by measuring the anteroposterior (ap) diameter of the tumor. the mr examination was performed using ecg gated scans with a 3 mm slice at 1.5 tesla. t1-weighted sagittal images were obtained. in 10 patients the appearance of the esophagus was normal, and in 44 patients a tumor was detected in the sag ... | 1997 | 9000349 |
| influence of thyroid status on water metabolism and survival of normal and dehydrated desert rodents meriones libycus. | the relationship between thyroid status and resistance to water deprivation in a desert rodent, meriones libycus, has been studied in normal, radiothyroidectomized (tx), and thyroidectomized t4-supplemented (1.5 microg t4/day) (tx + t4) animals. in animals given free access to water, 1 month after thyroidectomy water influx and efflux decreased 3-fold. this decrease was partially corrected after 5 days of t4 administration. thyroidectomy did not modify urinary osmolality nor affect survival. in ... | 1997 | 9000462 |
| tissue-specific alterations in insulin-like growth factor-i concentrations in response to 3,3',5-triiodo-l-thyronine supplementation in the growth hormone receptor-deficient sex-linked dwarf chicken. | insulin-like growth factor-i (igf-i) mediates many of the effects of growth hormone (gh). the regulation of igf-i, independent of gh, is methodologically difficult to assess in vivo, as hypophysectomy results in derangement of many pituitary hormone axes in addition to gh, and a gene knockout model is not available. the recessive sex-linked dwarfing (sld) gene (dw) in chickens results in a lack of functional target tissue gh receptors due to a variety of molecular defects, which provides a uniqu ... | 1997 | 9000465 |
| utility of thyroid function screening in adolescent psychiatric inpatients. | thyroid function abnormalities have been associated with psychiatric symptoms. this study examines the utility of thyroid screening among adolescent psychiatric inpatients. | 1997 | 9000787 |
| [bronchogenic carcinoma located in the aortic window]. | in the patients with invasion to the aortic window, we performed operation via median sternotomy combined with anteroaxillar thoracotomy. in such patients with t4 invasion, conventional pneumonectomy could not be performed because of the extensive invasion near the main pulmonary artery trunk. in these patients in this study, complete resection of the involved pulmonary artery could be performed using a vascular clamp without cp bypass. operative technique was as follows: first, the pericardium ... | 1997 | 8990811 |
| investigation of the effects of hyperthyroidism on renal function in the cat. | this study evaluated the effects of thyroxine on renal function in the cat. baseline serum thyroxine (t4) concentrations, clinicopathologic data (complete blood count [cbc], serum chemistry panel, urinalysis), and nuclear medicine determinations of glomerular filtration rate (gfr), effective renal plasma flow (erpf), and effective renal blood flow (erbf) were measured in 10 normal adult cats. cats were then injected with thyroxine (t4) (50 micrograms/kg sq) daily for 30 d to induce hyperthyroidi ... | 1997 | 9008802 |
| radiotherapy for localized prostate carcinoma. the correlation of pretreatment prostate specific antigen and nadir prostate specific antigen with outcome as assessed by systematic biopsy and serum prostate specific antigen. | the objective of this study was to correlate the failure pattern of localized prostate carcinoma after radiotherapy (rt) with pretreatment (pretx) psa and post-rt nadir psa, using systematic biopsies and serum psa in the assessment of outcome. | 1997 | 9010106 |
| influence of coronary artery bypass surgery on thyroid hormone parameters. | the postoperative period after cardiac surgery with cardiopulmonary bypass (cpb) is associated with a low t3 syndrome, i.e. low t3 and ft3 concentrations in the presence of normal t4 and tsh concentrations. so far, results from studies evaluating thyroid function during and after cpb are rather conflicting. we therefore evaluated prospectively thyroid function in 28 patients before, during and up to 3 days after coronary artery bypass surgery. we could demonstrate the most significant changes in ... | 1997 | 9010711 |
| the effect of diabetes mellitus on endocrine and reproductive function. | the adverse effects of diabetes on the circulatory, visual, renal, and peripheral nervous system are commonly recognized and have been extensively studied. the effects of decreased insulin secretion or resistance to insulin action on endocrine glands have not been as carefully documented. both clinical and animal research have demonstrated that diabetes mellitus is commonly associated with altered thyroid, adrenal and gonadal function. some of these changes are reversed with insulin replacement ... | 1997 | 9012356 |
| uv endonuclease of micrococcus luteus, a cyclobutane pyrimidine dimer-dna glycosylase/abasic lyase: cloning and characterization of the gene. | the gene of micrococcus luteus uv endonuclease (cyclobutane pyrimidine dimer-dna glycosylase/ abasic lyase) was cloned and characterized. the cloned gene, whose product had a predicted molecular mass of 17,120 da, was found to be capable of complementing the escherichia coli uvra6 mutation in vivo with respect to resistance to acetonemediated molecular photosensitization, a treatment producing exclusively cyclobutane pyrimidine dimers in dna. it also generated a nicking activity specific for pho ... | 1997 | 9012829 |
| purification and characterization of the small subunit of phage t4 terminase, gp16, required for dna packaging. | phage t4 terminase is an enzyme that binds to the portal protein of proheads and cuts and packages concatemeric dna. the t4 terminase is composed of two subunits, gene products (gp) 16 and 17. the role of the small subunit, gp16, in t4 dna packaging is not well characterized. we developed a new purification procedure to obtain large quantities of purified gp16 from an overexpression vector. the pure protein is found in two molecular weight forms, due to specific c-terminal truncation, displays i ... | 1997 | 9013596 |
| successful treatment of esthesioneuroblastoma and neuroendocrine carcinoma with combined chemotherapy and proton radiation. results in 9 cases. | to study the efficacy of a newly designed treatment strategy for esthesioneuroblastoma and neuroendocrine carcinoma of the paranasal sinuses. | 1997 | 9006501 |
| traumatic spinal cord injury: a neuropathological study on the longitudinal spreading of the lesions. | eight patients died after traumatic spinal cord injuries. at autopsy, neuropathological examination revealed longitudinal spreading of cord lesions in two of these patients. one developed progressive paralysis 43 h after fracture of the fifth cervical (c5) vertebra and died 38 days after injury. necrotic lesions extended upward to the medulla oblongata and downward to the c7 cord segment. pencil-shaped necrosis (c7-t4) and marginal spongiosis (c7-t2) were also found. a second patient died 5 mont ... | 1997 | 9006652 |
| regulation of t4 phage aerobic ribonucleotide reductase. simultaneous assay of the four activities. | we have devised an assay procedure that permits simultaneous monitoring of the four activities of ribonucleotide reductase. using this assay, we have compared the reduction of all four substrates by the t4 bacteriophage aerobic ribonucleotide reductase within different allosteric environments. specifically, we compared the relative turnover rates by the enzyme when activated with "in vivo" concentrations of the known allosteric effectors versus activation by atp alone. consistent with the known ... | 1997 | 9006929 |
| mechanism of thiazopyr-induced effects on thyroid hormone homeostasis in male sprague-dawley rats. | chronic administration of thiazopyr in the diet at dose levels of 1000 and 3000 ppm, but not 100 ppm, has demonstrated an increase in thyroid follicular cell tumors in male sprague-dawley rats. in the studies reported here we have evaluated the mechanism of thiazopyr-induced thyroid tumors by studying the effect of thiazopyr on a number of endpoints that indicate hypothalamic-pituitary-thyroid homeostasis. at a dose level of 3000 ppm, thiazopyr caused a marked depression in circulating levels of ... | 1997 | 9007042 |
| identification of hormonogenic tyrosines in fragment 1218-1591 of bovine thyroglobulin by mass spectrometry. hormonogenic acceptor tyr-12donor tyr-1375. | a fragment of bovine thyroglobulin encompassing residues 1218-1591 was prepared by limited proteolysis with thermolysin and continuous-elution polyacrylamide gel electrophoresis in sds. the reduced and carboxymethylated peptide was digested with endoproteinase asp-n and fractionated by reverse-phase high performance liquid chromatography. the fractions were analyzed by electrospray and fast atom bombardment mass spectrometry in combination with edman degradation. the post-translational modificat ... | 1997 | 8995307 |
| effect of r-interferon alpha administration on hypothalamus-pituitary-thyroid axis in chronic hepatitis. | recent studies pointed out the development of autoimmune thyroid diseases during interferon (ifn) therapy, mainly in patients with positive thyroid autoantibodies (msab and tgab) before treatment. the effects of recombinant human ifn alpha (rhifnalpha) on thyroid function and thyroid autoantibodies were studied in 12 patients with chronic active hepatitis associated with virus b or c, selected on the basis of negative results for msab and tgab. no significant variation in t3, t4 and tsh levels w ... | 1997 | 8995531 |
| association of the parainfluenza virus fusion and hemagglutinin-neuraminidase glycoproteins on cell surfaces. | we previously observed that cell fusion caused by human parainfluenza virus type 2 or type 3 requires the expression of both the fusion (f) and hemagglutinin-neuraminidase (hn) glycoproteins from the same virus type, indicating that a type-specific interaction between f and hn is needed for the induction of cell fusion. in the present study we have further investigated the fusion properties of f and hn proteins of parainfluenza virus type 1 (pi1), type 2 (pi2), and type 3 (pi3), sendai virus (sn ... | 1997 | 8985396 |
| sandostatin lar in acromegalic patients: long-term treatment. | we have evaluated the long term effects and safety of sandostatin lar, a long acting formulation of octreotide, during 18 subsequent injections given every fourth week to 14 octreotide-sensitive acromegalic patients. the dosages (20, 30, or 40 mg) were adjusted according to gh response, side-effects, or symptom relief and assessed on day 28 after each injection. we found a stable and consistent suppression of gh and insulin-like growth factor (igf-i) during the entire study period. daily mean gh ... | 1997 | 8989226 |
| acute effects of amiodarone administration on thyroid function in patients with cardiac arrhythmia. | because little has been published on early effects of treatment with amiodarone on thyroid function, we studied serum total and free thyroid hormone, reverse t3, and tsh levels in patients with cardiac arrhythmias during the first 10 days of treatment with a loading dose of amiodarone by iv infusion. twenty-four patients were enrolled in the study. a standardized loading regimen for the i.v. infusion of amiodarone was used. the protocol provided the i.v. infusion of 20 mg/kg per day on day 1, th ... | 1997 | 8989273 |
| the effects of epidural anesthesia on the neuroendocrine response to major surgical stress: a randomized prospective trial. | it has long been held that the acute-phase and neuroendocrine response to stress requires afferent neural input for its propagation. to further clarify the role of afferent neural impulses in this process and to determine the ability of epidural anesthesia to attenuate the normal perioperative stress response, 39 patients undergoing uncomplicated abdominal aortic replacement were randomized to receive either general anesthesia with postoperative patient-controlled intravenous morphine (n = 19) o ... | 1997 | 8985076 |
| purification and substrate specificity of polydeoxyribonucleotide kinases isolated from calf thymus and rat liver. | damage to dna can result in strand breaks with 5'-hydroxyl and 3'-phosphate termini. before dna polymerases and ligases can rejoin the broken strands, such termini have to be restored to 5'-phosphate and 3'-hydroxyl groups. polydeoxynucleotide kinase is an enzyme that may fulfil this function. we have purified the kinases from calf thymus and rat liver to near homogeneity. based on sds-polyacrylamide gel electrophoresis and activity gels, the enzymes from both sources are approximately 60-kda po ... | 1997 | 9027586 |
| [surgical treatment of t4 primary lung cancer]. | we investigated 257 t4 primary lung cancer patients who received operation in 30 hospitals of a lung cancer surgical therapy group of chubu and present the results of questionnaires on the outcomes of surgical treatment for the t4 cases. t4 cases were classified as follows; 147 resections (57.4%); 110 exploratory thoracotomies (42.8%) ; 90 pleural dissemination and pleural effusions; 33 aorta; 30 left atrium and 17 superior vena cava. survival rate of the t4 lung cancer patients in resection gro ... | 1997 | 9028063 |
| [the significance of surgical treatment for t4 lung cancer]. | a total of 114 pt4 patients underwent pulmonary resection from january 1980 to december 1993 at our hospital. the overall five-year survival rate of the 114 cases was 17%. there was no significance between the five-year survival rate of squamous cell carcinoma and that of adenocarcinoma. five-year survival rates of 17 patients with n0 disease, 29 patients with n1 disease, 51 patients with n2 disease, 1 patients with n3 disease, and 16 patients with nx disease were 40%, 21%, 21%, 0%, and 0%, resp ... | 1997 | 9028064 |
| [treatments for t4 advanced lung cancer with invasion to the superior vena cava]. | we discussed on the treatments for t4 lung cancer with invasion to the superior vena cava, whose prognosis has been poor. however, surgical resection may improve the prognosis compared with radiation therapy. the prosthetic replacement of superior vena cava can be done safely, and its patency is good in cases of ring-enforced eptfe graft. although superior vena caval obstruction syndrome had been a hard issue in the advanced cases, stenting in superior vena using the interventional radiological ... | 1997 | 9028065 |
| [t4 lung cancer: surgical indications based on results of surgical treatment]. | during the period of 1981 and 1995, 54 patients with t4 lung cancer underwent pulmonary resection in our institutes. the actuarial survival rate of them was 30% at three years and 12% at five years. the five-year survival rate of 12 patients with complete resection was 33%. on the other hand, the five-year survival rate of 30 patients with incomplete resection was 9%. the five-year survival rates of 17 patients with n0 disease, 9 patients with n1 disease, and 22 patients with n2 disease were 13% ... | 1997 | 9028066 |
| [a successful removal of t4 lung cancer with its left atrial extension using cardiopulmonary bypass]. | a 42-year-old man presented with cough, chest pain and dyspnea. the chest roentgenogram revealed a large mass shadow in the right upper and middle lobes with atelectasis and pleural effusion. massive polypoid tumor extending into the left atrium was diagnosed by computed tomography and two dimensional echocardiography. in order to prevent sudden death and cardiac failure, surgery was performed. at first, the polypoid tumor in the left atrium was removed with a partial resection of the left atria ... | 1997 | 9028067 |
| [surgical treatment of t4 lung cancer: combined resection of lung and heart or great vessels]. | from 1980 to 1995, sixteen patients with t4 lung cancer underwent resection of left atrium (la) or great vessels combined with pulmonary resection. for eight patients with lung cancer invading la, la was resected under simple clamp of la in seven cases, and under extracorporeal circulation in one case. for three patients with lung cancer invading aorta, resection and reconstruction of aorta was performed under femoro-femoral bypass in one case, and under temporary bypass using a heparin-coated t ... | 1997 | 9028068 |
| [assessment of surgery for primary lung cancer with dissemination or malignant effusion of pleura (t4 advanced lung cancer)]. | twenty-four cases of primary lung cancer with dissemination or malignant effusion of pleura detected preoperatively or intraoperatively were surgically treated at our hospital. mean survival time (mst) and two-year survival rate (2 ysr) were analyzed on their resected cases and non-resected cases with similar lesion. mst and 2 ysr of 19 cases with lobectomy, 5 cases with pneumonectomy including pleuropneumonectomy and 15 cases with no surgical procedure were 2.77 +/- 0.60 years, 53.4%, 1.51 +/- ... | 1997 | 9028069 |
| [results of surgical treatment of t4 lung cancer]. | a total of 381 patients with primary lung cancer including 30 cases of t4 lesion, were surgically treated at our hospital from june 1975 through july 1996. extended resection was performed in 11 patients. the 5-year survival rate after operation for all cases of t4 lung cancer, including one with operative death was 15.2%. six patients who had curative operation showed no significant prolonged survival when compared to 24 patients who resulted in non-curative operation, but the median survival t ... | 1997 | 9028070 |
| surface tension kinetics of the wild type and four synthetic stability mutants of t4 phage lysozyme at the air-water interface | surface tension kinetics exhibited by the wild type and selected stability mutants of t4 lysozyme at the air-water interface were monitored with dunouy tensiometry. mutant lysozymes were produced by substitution of the isoleucine at position 3 with cysteine, leucine, glycine, and tryptophan. each substitution resulted in an altered structural stability quantified by a change in the free energy of unfolding. surface pressure kinetics were compared to the kinetic model evolving from a simple model ... | 1997 | 9028884 |
| identification and quantitation of iodotyrosines and iodothyronines in proteins using high-performance liquid chromatography by photodiode-array ultraviolet-visible detection. | we describe a new method for the separation, identification and quantitation of iodotyrosines and iodothyronines [3-monoiodo-l-tyrosine (mit), 3,5-diiodo-l-tyrosine (dit), l-thyronine (t0), 3,5-diiodo-l-thyronine (t2), 3,5,3'-triiodo-l-thyronine (t3), reverse 3,3',5'-triiodo-l-thyronine (rt3) and 3,3',5,5'-tetraiodo-l-thyronine (t4)]. reversed-phase high-performance liquid chromatography (rp-hplc) was performed on a nucleosil c8 column with photodiode-array uv-vis detection. a clearly defined el ... | 1997 | 9029324 |
| thyroid function in children with different lipoprotein profiles: observations in a biracial (black/white) population--the bogalusa heart study. | abnormalities of thyroid function are associated with hyperlipidemia, a risk factor for coronary artery disease that starts in childhood. we investigated the age-, race-, and sex-related differences in thyroid function and its relation to serum lipoprotein levels in children (n = 363) aged 6 to 18 years from the biracial (black/white) community of bogalusa, louisiana, using an ultrasensitive thyroid-stimulating hormone (tsh) assay. serum levels of lipoprotein cholesterol fractions, triglycerides ... | 1997 | 9030672 |
| quaternary structure of the extracellular haemoglobin of the lugworm arenicola marina: a multi-angle-laser-light-scattering and electrospray-ionisation-mass-spectrometry analysis. | to elucidate the quaternary structure of the extracellular haemoglobin (hb) of the marine polychaete arenicola marina (lugworm) it was subjected to multi-angle laser-light scattering (malls) and to electrospray-ionisation mass spectrometry (esi-ms). it was also subjected to sds/page analysis for comparative purposes. malls analysis gave a molecular mass of 3648 +/- 24 kda and a gyration radius of 11.3 +/- 1.7 nm. maximum entropy analysis of the multiply charged electrospray spectra of the native ... | 1997 | 9030725 |
| pituitary neuromedin b content in experimental fasting and diabetes mellitus and correlation with thyrotropin secretion. | fasting and diabetes mellitus in the rat model have been associated with abnormalities of thyrotropin (tsh) secretion. neuromedin b is a bombesin-like peptide highly concentrated in the pituitary gland that has been shown to have inhibitory action on tsh secretion, acting as an autocrine/paracrine factor. here, we aimed to determine if the pituitary content of neuromedin b would change in fasted rats (1, 2, 3, and 4 days of food deprivation) and streptozotocin (55 mg/kg body weight)-diabetic rat ... | 1997 | 9030820 |
| using t4 dna polymerase to generate clonable pcr products. | 1997 | 9031131 | |
| effects of thyroid status on pituitary gonadotropin and testicular reserve in men. | this investigation was conducted to evaluate the effect of thyroid dysfunction on the pituitary-gonadal axis. ten men with graves' disease and 5 hypothyroid patients were studied; 10 normal males were studied as a control group. in untreated conditions hyperthyroidism was associated with a normal serum-free testosterone concentration, an increased serum of 17ohp levels, a reduced testosterone response to hcg stimulation, and a hyperresponse of lh to gnrh. these abnormalities reverted after norma ... | 1997 | 9017126 |
| metal ion interaction with cosubstrate in self-splicing of group i introns. | the catalytic mechanism for self-splicing of the group i intron in the pre-mrna from the nrdb gene in bacteriophage t4 has been investigated using 2'-amino- 2'-deoxyguanosine or guanosine as cosubstrates in the presence of mg2+, mn2+and zn2+. the results show that a divalent metal ion interacts with the cosubstrate and thereby influences the efficiency of catalysis in the first step of splicing. this suggests the existence of a metal ion that catalyses the nucleophilic attack of the cosubstrate. ... | 1997 | 9016608 |
| rna polymerase ii stalled at a thymine dimer: footprint and effect on excision repair. | bulky lesions in the template strand block the progression of rna polymerase ii (rnap ii) and are repaired more rapidly than lesions in the non-transcribed strand, which do not block transcription. in order to better understand the basis of this transcription-coupled repair we developed an in vitro system with purified transcription and nucleotide excision repair proteins and a plasmid containing the adenovirus major late promoter and a thymine dimer in the template strand downstream of the tran ... | 1997 | 9016630 |
| inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders. | the author's goal was to investigate relationships between peripheral thyroid hormone levels and cerebral blood flow (cbf) and cerebral glucose metabolism in affectively ill patients. | 1997 | 9016272 |
| efficacy of helical ct in t-staging of gastric cancer. | the purpose of this study was to evaluate the performance of helical ct in preoperative t-staging in patients with gastric cancer. | 1997 | 9022773 |
| clinical review 86: euthyroid sick syndrome: is it a misnomer? | alterations in thyroid function tests are very common in patients with nti. multiple, complex, and incompletely understood mechanisms are involved in these abnormalities. knowledge of these abnormalities is necessary to avoid errors in the diagnosis of thyroid disease. measurement of serum tsh, free t4, and free t3 levels by direct equilibrium dialysis/ria methods probably yield most useful (accurate) information in the setting of nti. patients with low free t4 by these methods and normal or low ... | 1997 | 9024211 |
| acute and subchronic inhalation studies on trifluoroiodomethane vapor in fischer 344 rats. | trifluoroiodomethane (cf3i) is being considered as a replacement compound for halon fire suppressants. its structure is similar to that of halon 1301 (cf3br), but it has very low ozone depletion potential compared to cf3br. as part of the process of developing environmental and health effects criteria, acute, 2-week, and 13-week nose-only inhalation toxicity studies were conducted in fischer 344 rats. in the acute study, three groups of 30 male rats each were exposed to 0 (control), 0.5, or 1.0% ... | 1997 | 9024674 |
| bacteriophage t4 development depends on the physiology of its host escherichia coli. | several parameters of phage t4 adsorption to and growth in escherichia coli b/r were determined. all changed monotonously with the bacterial growth rate (mu), which was modified by nutritional conditions. adsorption rate was faster at higher mu values, positively correlated to cell size, and increased by pretreatment with low penicillin (pn) concentrations; it was directly proportional to total cellular surface area, indicating a constant density of t4 receptors on cell envelopes irrespective of ... | 1997 | 9025292 |
| isolation of a gp20-complex and its role in in vitro assembly of both prohead and core of bacteriophage t4. | the product of gene 20 (gp20) in bacteriophage t4 forms the proximal vertex of the head. it has been suggested that gp20-rich fractions derived from the proheads can initiate core assembly in vitro and that gp20 plays an important role in prohead and core assembly. however, the gp20 isolated from proheads or overproducing cells harboring gene 20 did not work in vitro, owing to a strong tendency to aggregate. native gp20 was purified from t4-infected escherichia coli hdb3-1 cells, since it was sh ... | 1997 | 9018139 |
| fifteen-year survival in prostate cancer. a prospective, population-based study in sweden. | to describe the natural history of initially untreated early-stage prostate cancer. a key secondary objective was to calculate long-term survival rates by stage, grade, and age at diagnosis. | 1997 | 9020270 |
| zinc site redesign in t4 gene 32 protein: structure and stability of cobalt(ii) complexes formed by wild-type and metal ligand substitution mutants. | phage t4 gene 32 protein (gp32) is a zinc metalloprotein which binds cooperatively and preferentially to single-stranded nucleic acids and functions as a replication and recombination accessory protein. zn(ii) coordination by gp32 employs a his-cys3 metal ligand donor set derived from the his64-x12-cys77-x9-cys87-x2-cys90 sequence in the ssdna-binding core domain of the molecule. crystallographic studies reveal that his64 and cys77 are derived from two independent beta-strands within a distorted ... | 1997 | 9020770 |
| effects of consecutive thiouracil exposures in the juvenile and adult single comb white leghorn chicken on body weight and reproductive performance. | the effects of consecutive exposures to dietary thiouracil (tu) in juvenile and adult single comb white leghorn chickens on plasma thyroxine (t4) concentrations, egg production (ep), egg weight (ew), concentrations eggshell quality were determined. thiouracil was provided in the feed at levels of 0, 0.1, or 0.2% (ptrt) from 0 to 6 wk of age and at levels of 0 or 0.1% (trt) from 32 to 38 wk of age. body weight gain was simulated but t4, ew, ep, and eggshell quality were generally reduced by 0.1% ... | 1997 | 9057201 |
| simple and cost effective clinical methods for measuring neuromuscular fade responses with emphasis on "train of four" fade. | to evaluate different pressure transducers, available in the operating room for pressure measurements, interfaced with common monitoring equipment, for quantitation of the train of four (tof) fade during clinical neuromuscular block (nmb). | 1997 | 9058248 |
| the development of transient hypothyroidism after iodine-131 treatment in hyperthyroid patients with graves' disease: prevalence, mechanism and prognosis. | recovery of thyroid function in patients following hypothyroidism induced by 131i therapy for graves' disease has been described, but only a few detailed clinical and biochemical studies of this phenomenon (transient hypothyroidism) have been published. the prevalence, mechanism, and final outcome of transient hypothyroidism in 260 patients with graves' disease treated with 131i was studied. | 1997 | 9059550 |
| five-year follow-up of percutaneous ethanol injection for the treatment of hyperfunctioning thyroid nodules: a study of 117 patients. | percutaneous ethanol injection (pei) has been suggested as an alternative to radioiodine and surgery for the treatment of autonomous thyroid nodules (atn). | 1997 | 9059552 |
| exon 1 leader sequences downstream of u5 are important for efficient human immunodeficiency virus type 1 gene expression. | in previous studies, little attention has been paid to maintaining the native hiv-1 leader sequence in reporter constructs analyzing the human immunodeficiency virus type 1 (hiv-1) promoter activity. to investigate a possible influence of the leader sequence on hiv-1-driven gene expression in the presence as well as in the absence of tat, an expression vector was designed for transcripts consisting of the native hiv-1 tat 1.4 mrna leader followed by the open reading frame for the bacterial chlor ... | 1997 | 9060629 |
| human p53 binds holliday junctions strongly and facilitates their cleavage. | holliday junctions in dna are generated as a product of homologous recombination events. to test the hypothesis that human p53 may bind to holliday junctions, synthetic junctions with four approximately 75-base pair (hol75) or approximately 565-base pair (hol565) arms were generated. as seen by electron microscopy, under conditions in which 50-61% of the hol565 dnas were bound by p53, 80-96% of the p53 was located specifically at the junction with, in the latter case, only 4% of the p53 visualiz ... | 1997 | 9054458 |
| alterations in the pituitary-thyroid and pituitary-adrenal axes--consequences of long-term mifepristone treatment. | the effects of short-term administration of the antiprogestin and antiglucocorticoid, mifepristone, have been well characterized. however, little is known about the effects of prolonged administration of mifepristone. we analyzed hormonal parameters in four female and three male patients with unresectable meningioma who were treated with mifepristone (200 mg/d) for 20 to 40 months. serum samples were collected at monthly intervals approximately 24 hours following mifepristone ingestion. serum th ... | 1997 | 9054472 |
| 32p-postlabelling analysis of isomeric 7-alkylguanine adducts of styrene oxide. | styrene 7,8-oxide, which reacts preferentially at the n-7 position of guanine, yielded two pairs of diastereomers 7-(1'-hydroxy-2'-phenylethyl)-dgmp (the alpha-isomer) and 7-(2-hydroxy-2-phenylethyl)-dgmp (the beta-isomer) on reaction with deoxyguanosine-3'-monophosphate (3'-dgmp). the alpha- and beta-isomers were formed in the ratio 32:68. t4 polynucleotide kinase preferentially mediated labelling of diastereomers corresponding to the beta-isomer. the beta-diastereomers showed a labelling effic ... | 1997 | 9054636 |
| [a case of primary squamous cell carcinoma of the ureter: biochemical modulation with cisplatin and 5-fluorouracil]. | a case of primary squamous cell carcinoma of the ureter is reported. a 62-year-old male presented with gross hematuria and paralysis of the left leg. abdominal computed tomographic (ct) scan and ultrasonography revealed left hydronephrosis, a massive tumor (8 x 7 cm) in the left distal ureter which invaded the pelvic bone (t4), and left obturator lymph node metastasis (n2). pathologic examination of the biopsy specimen revealed poorly differentiated squamous cell carcinoma. cisplatin (100 mg/m2, ... | 1997 | 9046421 |
| the neurovascular infrahyoid muscle flap: a new method for tongue reconstruction. | objective: description of a new neurovascular island flap derived from the infrahyoid muscles to reconstruct a total tongue or large defects of the tongue base. the surgical technique, anatomic findings, and the postoperative function tests with the patients' outcome are described. eleven patients had tongue cancer, 5 at a t2 stage, 3 at a t3 stage, and 3 at a t4 stage. four patients underwent total glossectomy, 3 patients underwent hemiglossectomy, and in 2 patients a half and in another 2 pati ... | 1997 | 9047178 |
| structural analysis of dna bending induced by tethered triple helix forming oligonucleotides. | in order to monitor dna flexibility, we have recently reported the design of an artificial dna bending system consisting of two triple helix forming oligonucleotides (tfos) connected by a flexible linker [akiyama, t., & hogan, m. e. (1996) proc. natl. acad. sci. u.s.a. 93, 12122-12127], which spans a single turn of dna helix. those data suggested that up to 60 degrees of bending deformation could be induced with an expenditure of energy which is much smaller than predicted from bulk flexibility ... | 1997 | 9047333 |
| splicing by overlap extension by pcr using asymmetric amplification: an improved technique for the generation of hybrid proteins of immunological interest. | major histocompatibility complex (mhc) proteins play a central role in the immune recognition of antigen. the generation of hybrid mhc molecules has been of great value in elucidating the structure: function relationships of these key glycoproteins. in this report, the generation of cdnas coding for seven such hybrid proteins is described. we have used the technique of splicing by overlap extension by the polymerase chain reaction (soe by pcr) [horton, r.m., hunt, h.d., ho, s.n., pullen, j.k. an ... | 1997 | 9047341 |
| thyrotropin expression in hypophyseal pars tuberalis-specific cells is 3,5,3'-triiodothyronine, thyrotropin-releasing hormone, and pit-1 independent. | the expression of tsh subunit genes (tsh alpha and -beta) in pituitary thyrotropes is primarily regulated via circulating thyroid hormone levels (t3) and the hypothalamic trh. hypophyseal pars tuberalis (pt)-specific cells also express both hormonal subunits of tsh, but do not resemble thyrotropes of the pars distalis (pd) with respect to their distinct morphology, secretion, and direct modulation of tsh expression by photoperiodic inputs and melatonin. to investigate whether this distinct regul ... | 1997 | 9048604 |
| maternal nonthyroidal illness and fetal thyroid hormone status, as studied in the streptozotocin-induced diabetes mellitus rat model. | we have used the streptozotocin-induced diabetes mellitus pregnant rat as a model of maternal nonthyroidal illness. we measured the effects of different degrees of diabetes mellitus on maternal body weight, the outcome of pregnancy, circulating glucose, insulin, t4, t3, rt3, and tsh in mother and fetus, t4 and t3 in maternal and fetal tissues, and iodothyronine deiodinases in liver, lung, and brain. all of the changes in thyroid hormone status typical of nonthyroidal illnesses were observed in t ... | 1997 | 9048623 |
| two-domain structure of the td intron-encoded endonuclease i-tevi correlates with the two-domain configuration of the homing site. | i-tevi, the t4 td intron-encoded endonuclease, catalyzes the first step in intron homing by making a double-strand break in the intronless allele within a sequence designated the homing site. the 28 kda enzyme, which interacts with the homing site over a span of 37 bp, binds as a monomer, contacting two domains of the substrate. in this study, limited proteolysis experiments indicate that i-tevi consists of two domains that behave as discrete physical entities as judged by a number of functional ... | 1997 | 9048944 |
| the effect of in vivo thyroxine treatment on insulin receptors, glucose transport and glut4 in rat adipocytes. | daily i.p. administration of thyroxine (t4; 50 micrograms/100 g bw) to adult male rats for one week doubled the thyroxinemia and induced significant augmentation of glycemia and insulinemia. hyperthyroxinemia was also manifested by significant elevation of liver malic enzyme activity and by the presence of smaller fat cells. adipocytes of t4 treated rats displayed significantly lower density of insulin receptors, decreased insulin stimulatory effect on glucose transport and less glucose transpor ... | 1997 | 9049648 |
| dissociation of motor activity circadian rhythm in rats after exposure to ld cycles of 4-h period. | for > 30 days wistar rats were subjected to six dark pulses per day (t4 cycles; 3 h light, 1 h dark) to study the possibility of dissociating their motor activity rhythm into distinct circadian components. rats of both sexes were used, one-half of which were pinealectomized to examine the effect of the pineal gland on the entrainment process. results show that when rats were maintained under t4 a 4-h rhythm in their motor activity was present. rats showed anticipatory activity to dark phases, su ... | 1997 | 9038996 |
| effect of gonadal steroid hormones on plasma growth hormone concentrations in sexually immature rainbow trout, oncorhynchus mykiss. | in the present study we investigated the effects of gonadal steroid hormones on plasma growth hormone (gh), triiodothyronine (t3), and thyroxine (t4) levels in steroid-primed sexually immature rainbow trout, oncorhynchus mykiss, in order to determine whether changes in plasma gh and thyroid hormone levels during sexual maturation are a result of elevated gonadal steroid levels or are an altered condition associated with reproduction (as proposed by sumpter et al., 1991b). we found no significant ... | 1997 | 9038257 |
| differential expression of multidrug resistance gene product, p-glycoprotein, in normal, dysplastic and malignant oral mucosa in india. | multidrug resistance (mdr) in human cancer is often associated with over-expression of the mdr-1 gene, which encodes a 170-kda transmembrane protein, termed p-glycoprotein (p-gp). we evaluated the immunoreactivity of p-gp in oral tissues at different stages of tumorigenesis in the indian population by flow cytometry, using the mrk-16 monoclonal antibody, which recognizes an external epitope of p-gp. the expression of p-gp was studied in human oral normal tissues (12 cases), dysplastic lesions (1 ... | 1997 | 9036881 |