Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| epidemiology of sexually transmitted infections in suspected child victims of sexual assault. | the objective of this study was to describe the epidemiology of neisseria gonorrhoeae, chlamydia trachomatis, trichomonas vaginalis, treponema pallidum, hiv, and herpes simplex virus type 2 (hsv-2) infection diagnosed by culture or by serologic or microscopic tests and by nucleic acid amplification tests in children who are evaluated for sexual victimization. | 2009 | 19564286 |
| gonococcal peritonitis diagnosed post laparotomy in a 38-year-old woman: a case report. | a 38-year-old south african lady with a background history of cervical intra-epithelial neoplasia and recent colposcopy presented to the emergency department with severe abdominal pain. initial investigations were non-diagnostic and despite empirical antibiotic therapy the patient developed peritonism. post-laprotomy the diagnosis of severe pelvic inflammatory disease and peritonitis secondary to infection with neisseria gonorrhoea was made. | 2009 | 20011634 |
| investigating the role of mitochondrial haplogroups in genetic predisposition to meningococcal disease. | meningococcal disease remains one of the most important infectious causes of death in industrialized countries. the highly diverse clinical presentation and prognosis of neisseria meningitidis infections are the result of complex host genetics and environmental interactions. we investigated whether mitochondrial genetic background contributes to meningococcal disease (md) susceptibility. | 2009 | 20019817 |
| failure to detect mycoplasma genitalium in the pharynges of female sex workers in japan. | to determine the prevalence of genital mycoplasmas and ureaplasmas in the pharynges of japanese female sex workers practicing fellatio on their clients, vaginal swabs and throat washings were collected from 403 female sex workers attending a clinic in kyoto, japan, for regular screening of gonococcal and chlamydial infections. neisseria gonorrhoeae, chlamydia trachomatis, mycoplasma genitalium, mycoplasma hominis, ureaplasma parvum, and ureaplasma urealyticum in vaginal and throat specimens were ... | 2009 | 20012733 |
| effect of various rinsing protocols after use of amine fluoride/stannous fluoride toothpaste on the bacterial composition of dental plaque. | this clinical study evaluated the effect of different oral hygiene protocols on the bacterial composition of dental plaque. after a 2-week period of using fluoride-free toothpaste, 30 participants followed three 1-week experimental protocols, each followed by 2-week fluoride-free washout periods in a randomized crossover examiner-blind controlled trial. the 1-week experimental protocols comprised the use of amf/snf(2) toothpaste twice daily, after which participants either (1) rinsed with tap wa ... | 2009 | 20016176 |
| molecular typing of neisseria gonorrhoeae isolates by opa-typing and ribotyping in new delhi, india. | control and preventive measures for gonococcal infections are based on precise epidemiological characteristics of n. gonorrhoeae isolates. in the present study the potential utility of opa-typing and ribotyping for molecular epidemiological study of consecutive gonococcal strains was determined. sixty gonococcal isolates were subjected to ribotyping with two restriction enzymes, avaii and hincii, and opa-typing with taqi and hpaii for epidemiological characterization of gonococcal population. ri ... | 2009 | 20016674 |
| prevalence of chlamydia trachomatis and neisseria gonorrhoeae in hiv-seropositive patients and gonococcal antimicrobial susceptibility: an update in thailand. | we surveyed the rate of chlamydial and gonococcal infections among human immunodeficiency virus (hiv)-seropositive patients in thailand as well as the current status of antimicrobial resistance of neisseria gonorrhoeae and determined the prevalence of penicillinase-producing n. gonorrhoeae (ppng) in thailand. a total of 1,158 endocervical swabs from 824 hiv-seropositive patients were collected to detect both organisms by gen-probe. the prevalences of chlamydial and gonococcal infection were 9.7 ... | 2009 | 19934542 |
| defining the healthy "core microbiome" of oral microbial communities. | most studies examining the commensal human oral microbiome are focused on disease or are limited in methodology. in order to diagnose and treat diseases at an early and reversible stage an in-depth definition of health is indispensible. the aim of this study therefore was to define the healthy oral microbiome using recent advances in sequencing technology (454 pyrosequencing). | 2009 | 20003481 |
| an 11 year old boy with chest pain and fever. | 2009 | 20007220 | |
| time from first intercourse to first sexually transmitted infection diagnosis among adolescent women. | to determine the time between first intercourse and first sexually transmitted infection (sti) with chlamydia trachomatis, neisseria gonorrhoeae, or trichomonas vaginalis and time between repeated infections. | 2009 | 19996047 |
| investigation of the genes involved in antigenic switching at the vlse locus in borrelia burgdorferi: an essential role for the ruvab branch migrase. | persistent infection by pathogenic organisms requires effective strategies for the defense of these organisms against the host immune response. a common strategy employed by many pathogens to escape immune recognition and clearance is to continually vary surface epitopes through recombinational shuffling of genetic information. borrelia burgdorferi, a causative agent of lyme borreliosis, encodes a surface-bound lipoprotein, vlse. this protein is encoded by the vlse locus carried at the right end ... | 2009 | 19997508 |
| endogenous endophthalmitis secondary to bacterial meningitis from neisseria meningitidis: a case report and review of the literature. | to report the case of a patient with endogenous endophthalmitis secondary to meningitis from neisseria meningitidis with early detection and good visual recovery. | 2009 | 19946520 |
| functional characterization of antibodies against neisseria gonorrhoeae opacity protein loops. | the development of a gonorrhea vaccine is challenged by the lack of correlates of protection. the antigenically variable neisserial opacity (opa) proteins are expressed during infection and have a semivariable (sv) and highly conserved (4l) loop that could be targeted in a vaccine. here we compared antibodies to linear (ab(linear)) and cyclic (ab(cyclic)) peptides that correspond to the sv and 4l loops and selected hypervariable (hv(2)) loops for surface-binding and protective activity in vitro ... | 2009 | 19956622 |
| [pathogenesis and clinical significance of interleukin-8 and tumor necrosis factor-alpha in cervicitis]. | to investigate the relationship between local immune status of vagina and the occurrence of disease in patients with cervicitis. | 2009 | 19957526 |
| [study on the bactericidal antibody against neisseria meningitidis serogroup c strains after immunization with a divalent polysaccharide (a plus c) vaccine]. | to optimize the serum bactericidal assay (sba), detect and analyze the bactericidal antibody level against neisseria meningitidis serogroup c strains after divalent polysaccharide (a plus c) vaccine immunization. | 2009 | 19957632 |
| mammalian cell transcriptome in response to meningitis-causing pathogens. | bacterial meningitis continues to be a major cause of mortality and morbidity, despite improved antimicrobial therapy. a key factor that contributes to this situation is the incomplete understanding of its pathogenesis. high-throughput methods (e.g., dna microarray technology) can provide a holistic picture of the transcriptional events that underlie the host response to bacterial infections, including that during bacterial meningitis. since 2001, several studies have been reported on the cellul ... | 2009 | 19895228 |
| chlamydia trachomatis and neisseria gonorrhoeae transmission from the oropharynx to the urethra among men who have sex with men. | limited data exist on the risk of chlamydia trachomatis and neisseria gonorrhoeae transmission from oropharynx to urethra. we examined urethral c. trachomatis and n. gonorrhoeae positivity among men who have sex with men (msm) seen at san francisco city clinic (san francisco, ca) during 2007. | 2009 | 19911970 |
| use of injectable progestin contraception and risk of sti among south african women. | this study was conducted to determine the association between the use of injectable progestin contraception (ipc) and the risk of infection with neisseria gonorrhoeae (gc), chlamydia trachomatis (ct), bacterial vaginosis (bv) and trichomonas vaginalis (tv) among women in south africa. | 2009 | 19913149 |
| [neisseria sicca]. | 2009 | 19915756 | |
| metronidazole resistance in trichomonas vaginalis from highland women in papua new guinea. | the prevalence of the sexually transmissible protozoan parasite trichomonas vaginalis in the highlands of papua new guinea (png) has been reported to be as high as 46% and although not previously studied in papua new guinea, clinical resistance against metronidazole (mz), the drug most commonly used to treat trichomoniasis, is well documented worldwide. this study was primarily aimed at assessing resistance to mz in t. vaginalis strains from the goroka region. | 2009 | 19917203 |
| prevalence of trichomonas vaginalis infection among young reproductive age women in india: implications for treatment and prevention. | trichomonas vaginalis infection is the most common curable sexually transmissible infection (sti) worldwide. the present study describes the burden and correlates of t. vaginalis infection among young reproductive age women in mysore, india. | 2009 | 19917204 |
| a physiologically significant role in nitrite reduction of the ccop subunit of the cytochrome oxidase cbb3 from neisseria gonorrhoeae. | the ccop subunit of cytochrome oxidase cbb(3) of neisseria gonorrhoeae is predicted to include a c-terminal extension in which there is a c-a-a-c-h- motif typical of heme attachment sites in c-type cytochromes. substitutions of key cysteine and histidine residues of this motif resulted in mutants that grew normally in oxygen-sufficient cultures and reduced oxygen at the same rate as the parent strain. in contrast, after oxygen-limited growth in the presence of nitrite, rates of nitrite reduction ... | 2009 | 19889029 |
| in brief: a new hib booster. | 2009 | 19890246 | |
| onsite infectious agents and toxins monitoring in 12 may sichuan earthquake affected areas. | at 14:28 on 12 may 2008, sichuan province of china suffered a devastating earthquake measuring 8.0 on the richter scale with more than 80 000 human lives lost and millions displaced. with inadequate shelter, poor access to health services, and disrupted ecology, the survivors were at enormous risk of infectious disease outbreaks. this work, believed to be unprecedented, was carried out to contain a possible outbreak through onsite monitoring of airborne biological agents in the high-risk areas. ... | 2009 | 19890556 |
| bacterial motility and clustering guided by microcontact printing. | type iv pili are bacterial nanomotors that mediate two opposing behaviors on surfaces, spreading and clustering. here we show that the velocity of motile neisseria gonorrhoeae depends quantitatively on the fluidity of the phospholipid membrane surface. using microcontact printing, we confined the surface motility to nonfluid islands within a fluid lipid membrane. on an array of islands, the transition from spreading to clustering was analyzed in real time and at the single cell level, showing th ... | 2009 | 19891453 |
| imported ciprofloxacin-resistant neisseria meningitidis. | 2009 | 19891885 | |
| evidence of a specific interaction between new synthetic antisepsis agents and cd14. | synthetic molecules derived from natural sugars with a positively charged amino group or ammonium salt and two lipophilic chains have been shown to inhibit tlr4 activation in vitro and in vivo. to characterize the mechanism of action of this class of molecules, we investigated possible interactions with the extracellular components that bind and shuttle endotoxin [lipopolysaccharide (lps)] to tlr4, namely, lbp, cd14, and md-2. molecules that inhibited tlr4 activation inhibited lbp.cd14-dependent ... | 2009 | 19928913 |
| use of nfsb, encoding nitroreductase, as a reporter gene to determine the mutational spectrum of spontaneous mutations in neisseria gonorrhoeae. | organisms that are sensitive to nitrofurantoin express a nitroreductase. since bacterial resistance to this compound results primarily from mutations in the gene encoding nitroreductase, the resulting loss of function of nitroreductase results in a selectable phenotype; resistance to nitrofurantoin. we exploited this direct selection for mutation to study the frequency at which spontaneous mutations arise (transitions and transversions, insertions and deletions). | 2009 | 19930647 |
| expression, purification and preliminary x-ray analysis of the neisseria meningitidis outer membrane protein porb. | the neisseria meningitidis outer membrane protein porb was expressed in escherichia coli and purified from inclusion bodies by denaturation in urea followed by refolding in buffered ldao on a size-exclusion column. porb has been crystallized in three different crystal forms: c222, r32 and p6(3). the c222 crystal form may contain either one or two porb monomers in the asymmetric unit, while both the r32 and p6(3) crystal forms contained one porb monomer in the asymmetric unit. of the three, the p ... | 2009 | 19851005 |
| bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis. | the bacterial porb porin, an atp-binding beta-barrel protein of pathogenic neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. porb is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial membrane potential (deltapsi(m)). here, we show that porb induces the condensation of the mitochondrial matrix and the loss of cristae structures, sensitizing cells to the induction of apoptosis via signaling pathways activated by bh3-only prote ... | 2009 | 19851451 |
| booster vaccinations: can immunologic memory outpace disease pathogenesis? | almost all current vaccines work by the induction of antibodies in serum or on the mucosa to block adherence of pathogens to epithelial cells or interfere with microbial invasion of the bloodstream. however, antibody levels usually decline after vaccination to undetectable amounts if further vaccination does not occur. persistence of vaccine-induced antibodies usually goes well beyond the time when they should have decayed to undetectable levels because of ongoing "natural" boosting or other imm ... | 2009 | 19933727 |
| prevalence of sexually transmitted infections among female adolescents aged 14 to 19 in the united states. | most young women initiate sexual activity during adolescence; risk for sexually transmitted infections (stis) accompanies this initiation. in this study we estimated the prevalence of the most common stis among a representative sample of female adolescents in the united states. | 2009 | 19933728 |
| [towards the universal protection of meningococcus: state-of-the-art of new vaccines]. | 2009 | 19935538 | |
| fluorescence resonance energy transfer (fret)-based subcellular visualization of pathogen-induced host receptor signaling. | bacteria-triggered signaling events in infected host cells are key elements in shaping the host response to pathogens. within the eukaryotic cell, signaling complexes are spatially organized. however, the investigation of protein-protein interactions triggered by bacterial infection in the cellular context is technically challenging. here, we provide a methodological approach to exploit fluorescence resonance energy transfer (fret) to visualize pathogen-initiated signaling events in human cells. | 2009 | 19939239 |
| a routine infant schedule versus an older infant/toddler schedule for neisseria meningitidis vaccination: what do experience and reason tell us? | 2009 | 19943757 | |
| [microbiological diagnosis of sexually transmitted infections (sti): part 1. non-viral sti]. | non-viral sexually transmitted infections (sti) are an important cause of physical, psychological and social distress, have severe consequences for women's reproductive health and may be transmitted to the newborn child. these infections are also risk factors for the acquisition and transmission of hiv and other sti, and for premature labor. in the last years we have observed a gradual decrease in the national incidence of gonorrhea. the implementation of a screening program in our country for c ... | 2009 | 20098788 |
| [study on immunogenicity of group a and group c meningococcal conjugate vaccine with coupling group b meningococcal outer membrane protein]. | to evaluate the immunogenicity of group a and group c meningococcal conjugate vaccine with coupling group b meningococcal outer membrane protein (men b-omp). | 2009 | 20084975 |
| [testing of antibodies against serogroup c neisseria meningitidis by serum bactericidal assay in healthy population, liaoning province]. | to test the serum antibodies from healthy population by serum bactericidal assay (sba), in order to evaluate the level of protective antibodies against serogroup c neisseria meningitidis in liaoning province. | 2009 | 20084976 |
| in silico identification of candidate drug and vaccine targets from various pathways in neisseria gonorrhoeae. | neisseria gonorrhoeae is responsible for causing gonorrhea, one of the most common sexually transmitted diseases prevailing globally. although extensive researches are in progress in order to control the transmission of the disease and to develop drug(s) against the pathogen, till date no effective vaccine or specific drug could be developed and only antibiotic treatment is in use. perhaps, due to excess use of antibiotics, several resistant strains have been found. in the present study, metabol ... | 2009 | 20109152 |
| [epidemiology of the meningococcal disease in catalonia before and after vaccination against serogroup c]. | meningococcal disease remains a serious public health problem worldwide. in catalonia, after implementing the vaccination program, there has been a significant decrease in cases caused by meningococcus c. | 2009 | 20111820 |
| serogroup c meningococcal osteomyelitis: a case report and review of the literature. | a rare case of a 7-year-old boy with acute hematogenous osteomyelitis caused by neisseria meningitidis serogroup c is presented. the diagnosis of osteomyelitis was made by bone scintigraphy and a blood culture confirmed meningococci as the cause of the disease. meningococcal osteomyelitis is exceptionally rare and to our knowledge, serogroup c meningococci have not been previously reported as a cause. | 2009 | 20135846 |
| [epidemiological characteristics of meningococcal meningitis in guangxi zhuang autonomous region during 1996 and 2007]. | to analyze the epidemiological characteristics of meningococcal meningitis and provide evidences for disease control. | 2009 | 20077678 |
| [research on the relationship between variable number of tandem repeats sequences and serogrouping of neisseria meningitis]. | to research the relationship between variable number of tandem repeats sequences (vntrs) in genome and serogrouping of neisseria meningitides (n. meningitidis). | 2009 | 20077737 |
| prevalence, phenotypic and genetic characteristics of prolyliminopeptidase-negative neisseria gonorrhoeae isolates in sweden during 2000-2007. | in neisseria gonorrhoeae culture diagnostics, species confirmation is commonly performed using commercial biochemical tests relying on prolyliminopeptidase (pip) activity. it was previously shown that one pip-negative strain was mainly globally transmitted during 2000-2004. the aims were to investigate the prevalence and phenotypic and genetic characteristics of pip-negative n. gonorrhoeae isolates in sweden during 2000-2007. gonococcal isolates (n = 1230) cultured in sweden during 2000-2007 wer ... | 2009 | 20078555 |
| menacwy-crm, a novel quadrivalent glycoconjugate vaccine against neisseria meningitidis for the prevention of meningococcal infection. | invasive meningococcal disease remains a major public health concern, with infants, children younger than 4 years and adolescents bearing the majority of the global disease burden. protecting the vulnerable individuals in these age groups through vaccination remains the most rational strategy for the prevention of meningococcal disease. the formulation of polysaccharide-protein conjugate vaccines has been a major breakthrough in vaccinology, and has extended protection against pathogenic encapsu ... | 2009 | 20072946 |
| condom use promotion among isixhosa speaking women living with hiv in the western cape province, south africa: a pilot study. | the prevalence of hiv infection continues to increase among women in south africa while there are few interventions specifically targeting condom use promotion in this population. we report the results of an experimental pilot study of a health education intervention aimed at enhancing coping skills and consistent condom use among hiv-positive women attending primary health clinics in the western cape province of south africa. one hundred and twenty women were randomised into the intervention co ... | 2009 | 20024738 |
| [hiv and sexually transmitted disease among female sex workers in benin]. | this report describes a follow-up study conducted in 2005 to evaluate programs intended to reduce hiv/aids among registered and unregistered female sex workers (fsw) and their male clients in six major urban areas in benin (cotonou, abomey-bohicon, parakou, porto-novo, kandi, malanville). the objectives of this second study combining laboratory testing and behavioral questionnaires were to estimate the prevalence of hiv and sexually transmitted diseases (sti), to determine the sociodemographic a ... | 2009 | 20025173 |
| denial of risk behavior does not exclude asymptomatic anorectal sexually transmitted infection in hiv-infected men. | the centers for disease control recommend screening for asymptomatic sexually transmitted infection (sti) among hiv-infected men when there is self-report of unprotected anal-receptive exposure. the study goals were: (1) to estimate the validity and usefulness for screening policies of self-reported unprotected anal-receptive exposure as a risk indicator for asymptomatic anorectal infection with neisseria gonorrhoeae (gc) and/or chlamydia trachomatis (ct). (2) to estimate the number of infection ... | 2009 | 20041143 |
| influence of two vaccination campaigns on genetic diversity of invasive neisseria meningitidis isolates in northern spain (1997-2008). | neisseria meningitidis diversifies rapidly, due to its high recombination rates. the aim of this study was to analyze the possible impact of two vaccination campaigns (a once-off a/c polysaccharide vaccination campaign in people aged 18 months to 20 years old in 1997, and a meningococcal c conjugate vaccination campaign in children aged < or = 6 years old from 2000 to 2008) on diversification of the population of invasive isolates obtained between 1997 and 2008. all of the 461 available isolates ... | 2009 | 20041148 |
| a novel phase variation mechanism in the meningococcus driven by a ligand-responsive repressor and differential spacing of distal promoter elements. | phase variable expression, mediated by high frequency reversible changes in the length of simple sequence repeats, facilitates adaptation of bacterial populations to changing environments and is frequently important in bacterial virulence. here we elucidate a novel phase variable mechanism for nada, an adhesin and invasin of neisseria meningitidis. the nadr repressor protein binds to operators flanking the phase variable tract and contributes to the differential expression levels of phase varian ... | 2009 | 20041170 |
| a clinicopathological study of urethritis in males. | to determine the etiology and frequency of different types of urethritis in adult males. | 2009 | 20042155 |
| genome-based vaccine development: a short cut for the future. | bacterial infectious diseases remain a major cause of deaths and disabilities in the world. although conventional vaccinology approaches were successful in conferring protection against several diseases, they failed in providing efficient vaccines against many others. together to the sequencing of the first genome, a new chapter in the vaccinology history started to be written. reverse vaccinology changed the way to think about vaccine development, using the information provided by the microorga ... | 2009 | 20047037 |
| annual report of the australian meningococcal surveillance programme, 2008. | in 2008, there were 260 laboratory-confirmed cases of invasive meningococcal disease (imd) analysed by the national neisseria network, a nationwide network of reference laboratories. one hundred and forty-nine isolates of neisseria meningitidis from invasive cases of meningococcal disease were available for which the phenotypes (serogroup, serotype and serosubtype) and antibiotic susceptibility were determined. an additional 111 cases were confirmed by non-culture based methods. nationally, 223 ... | 2009 | 20047198 |
| annual report of the australian gonococcal surveillance programme, 2008. | the australian gonococcal surveillance programme monitors the antibiotic susceptibility of neisseria gonorrhoeae isolated in all states and territories. in 2008 the in vitro susceptibility of 3,110 isolates of gonococci from public and private sector sources was determined by standardised methods. different antibiotic susceptibility patterns were again seen in the various jurisdictions and regions. resistance to the penicillins nationally was at 44% and ranged between 25% in queensland and 73% i ... | 2009 | 20047199 |
| [sexually-transmitted disease prevalence and the factors associated with it in sexually-exploited children in bogota, colombia]. | presenting the characteristics of a group of children who have been sexually exploited in bogota, determining the prevalence of sexually-transmitted disease (std) in this group of children and establishing the factors associated with std in this population. | 2009 | 20027519 |
| [purpura fulminans (symmetric peripheral gangrene): 7-year consecutive case review in japan]. | acute infectious purpura fulminans (aipf), a rare syndrome of infection-induced ischemic necrosis of the extremities (symmetric peripheral gangrene), is due most often to neisseria meningitidis in the us and the uk, but is not endemic to japan. | 2009 | 20034317 |
| an unusual case of meningococcal meningitis complicated with subdural empyema in a 3 month old infant: a case report. | subdural empyema is an unusual complication of meningococcal meningitis, and in acute cases can be rapidly fatal. we present a case of an 8 week old infant who presented with atypical neisseria meningitis with bifrontal subdural empyema formation. through the utilisation of modern polymerise chain reaction tests on cerebrospinal fluid samples, we were able to confirm the diagnosis and institute appropriate treatment. early surgical intervention and appropriate intravenous antibiotics meant that ... | 2009 | 20181146 |
| gonococcal peritonitis diagnosed post laparotomy in a 38-year-old woman: a case report. | a 38-year-old south african lady with a background history of cervical intra-epithelial neoplasia and recent colposcopy presented to the emergency department with severe abdominal pain. initial investigations were non-diagnostic and despite empirical antibiotic therapy the patient developed peritonism. post-laprotomy the diagnosis of severe pelvic inflammatory disease and peritonitis secondary to infection with neisseria gonorrhoea was made. | 2009 | 20181206 |
| invasive pediatric neisseria meningitidis infections. | neisseria meningitidis usually causes severe infection in children, but occurs only sporadically in taiwan. however, the number of infections increased in 2001 and 2002. this study was performed to ascertain the epidemiology and clinical manifestations of infections caused by meningococcus in a pediatric population. | 2009 | 20182673 |
| sr-a, marco and tlrs differentially recognise selected surface proteins from neisseria meningitidis: an example of fine specificity in microbial ligand recognition by innate immune receptors. | macrophages express various classes of pattern recognition receptors involved in innate immune recognition of artificial, microbial and host-derived ligands. these include the scavenger receptors (srs), which are important for phagocytosis, and the toll-like receptors (tlrs) involved in microbe sensing. the class a macrophage scavenger receptor (sr-a) and macrophage receptor with a collagenous structure (marco) display similar domain structures and ligand-binding specificity, which has led to th ... | 2009 | 20375573 |
| clinical behavior of streptococcus pneumoniae meningoencephalitis. | there was an increased number of cases of meningoencephalitis caused by streptococcus pneumoniae, after the successful vaccination campaigns against neisseria meningitidis and haemophilus influenzae. this paper aims at describing the clinical characteristics, the laboratory findings, the complications, and the therapeutic management of these patients, who have been suffering from this disease since 1993 to 2006. | 2009 | 20069213 |
| hijacking transferrin bound iron: protein-receptor interactions involved in iron transport in n. gonorrhoeae. | neisseria gonorrhoeae has the capacity to acquire iron from its human host by removing this essential nutrient from serum transferrin. the transferrin binding proteins, tbpa and tbpb constitute the outer membrane receptor complex responsible for binding transferrin, extracting the tightly bound iron from the host-derived molecule, and transporting iron into the periplasmic space of this gram-negative bacterium. once iron is transported across the outer membrane, ferric binding protein a (fbpa) m ... | 2009 | 20161024 |
| mum's the word: factors that influenced young adults' participation in the new zealand meningococcal b immunisation programme. | to identify the factors that influenced young adults (aged 16-19 years) when deciding whether or not to be immunised during the menzb campaign. | 2009 | 20148042 |
| sexually transmitted diseases and anorectum. | sexually transmitted diseases (std) are a major public health problem because their incidence is increasing worldwide despite prevention campaigns and because they raise the risk of hiv infection. anorectal localisations of std are common among men who have sex with men (msm) but can also be seen among heterosexuals (men or women). transmission of such infections is due to anal sex or to other sexual behaviours like "fisting". although some pathogens (like human papillomavirus-hpv) are common in ... | 2009 | 20163035 |
| a comparative study of single-dose treatment of chancroid using thiamphenicol versus azithromycin. | a study was conducted in são paulo, brazil, to compare azithromycin with thiamphenicol for the single-dose treatment of chancroid. in all, 54 men with chancroid were tested. the etiology was determined by clinical characterization and direct bacterioscopy with gram staining. none of the patients had positive serology or dark-field examination indicating active infection with treponema pallidum. genital infections due to neisseria gonorrhoeae and herpes simplex virus were excluded by polymerase c ... | 2009 | 20191200 |
| [the monitoring of neisseria gonorrhoeae infection incidence and its resistance in suceava county]. | neisseria gonorrhoeae infection is one of the most frequent infections transmitted on sexual intercourse. in the last decades, a significant numbers of gonococcus strains were resistant to penicillin, tetracycline, quinolones and, in the last period, resistant to 3rd generation cephalosporines too. the purpose of this study was to monitor the trend of n. gonorrhoeae isolates from 2004-2008, in suceava county, north-east region of romania. | 2009 | 20191906 |
| pathophysiology and treatment of bacterial meningitis. | bacterial meningitis is a medical emergency requiring immediate diagnosis and immediate treatment. streptococcus pneumoniae and neisseria meningitidis are the most common and most aggressive pathogens of meningitis. emerging antibiotic resistance is an upcoming challenge. clinical and experimental studies have established a more detailed understanding of the mechanisms resulting in brain damage, sequelae and neuropsychological deficits. we summarize the current pathophysiological concept of acut ... | 2009 | 21180625 |
| clinical efficacy of the various drugs used in the treatment of gonorrhoeae. | gonorrhoea is a purulent inflammation of mucus membrane of the genital tract and is a highly contagious sexually transmitted disease (std) caused by the bacterium neisseria gonorrhoae. both men and women can be infected through a variety of sexual contact behaviours including vaginal, anal or oral intercourses. this comparative study was carried out in new gulail polyclinic jeddah, ksa from jan 2003 to march 2004 to find the clinical efficacy of ciprofloxacin, ceftriaxone and spectinomycin, the ... | 2009 | 21067018 |
| [study of hypervirulent complexes of neisseria meningitidis by methods of molecular biology and possibility of their prevention in the czech republic by vaccination]. | a brief report is presented of the results of the project of the internal grant agency of the ministry of health of the czech republic that received the medical research award 2008 from the minister of health of the czech republic (http://www.mzcr.cz/odbornik/pages/816-udeleni-ceny-ministra-zdravotnictvi-pro-rok-2008.html). the science council of the internal grant agency of the ministry of health of the czech republic selected 5 award winners of 16 candidate projects recommended by the specialt ... | 2009 | 21114007 |
| coevolution of dna uptake sequences and bacterial proteomes. | dramatic examples of repeated sequences occur in the genomes of some naturally competent bacteria, which contain hundreds or thousands of copies of short motifs called dna uptake signal sequences. here, we analyze the evolutionary interactions between coding-region uptake sequences and the proteomes of haemophilus influenzae, actinobacillus pleuropneumoniae, and neisseria meningitidis. in all three genomes, uptake sequence accumulation in coding sequences has approximately doubled the frequencie ... | 2009 | 20333176 |
| the prevalence of some bacterial markers in female patients undergoing an initial infertility evaluation in north-east romania. | genital infections represent one of the most important causes of infertility, affecting: fallopian tubes, endometrial mucosa, sperm parameters. the aim of this study is to evaluate the involvement of four sexually transmitted infections (std) in the achievement of infertility and to establish the prevalence of each infectious agent in our patients. | 2009 | 20361538 |
| an infant with meningococcal arthritis of the hip. | meningococcus is a well known cause of meningitis and septicaemia. it is less well known as a cause of arthritis. this case report describes an infant with meningococcal arthritis and with further discussion of the role of meningococcal serogroup w135 in disease, as well as current and future immunisation strategies. | 2009 | 20416000 |
| [study progress on serogroup b meningococcal vaccine]. | meningococcal disease, caused by neisseria meningitidis (nm), is still one serious threatening infectious disease with high mortality. vaccination is available for prevention and control of such disease. based on the chemical structure of capsule polysaccharide, nm strains were classified into 13 serogroups. meningococcal polysaccharide vaccines and polysaccharide conjugated protein vaccine against serogroup a, c, w135 and y were efficacious and have been widely used. because of poor immunogenic ... | 2009 | 20518335 |
| increases in gonorrhea among high school students following hurricane katrina. | to determine the prevalence of neisseria gonorrhoeae in a student population before hurricane katrina and after their residential neighbourhoods were devastated in the wake of the hurricane. | 2009 | 18955385 |
| [chronic meningococcal meningitis in an adult]. | a 46-year-old woman was admitted for a four-month history of progressive cognitive and behavioral disorders. mri revealed hydrocephalus with meningeal enhancement after gadolinium infusion. the lumbar puncture found a purulent csf containing 305 nucleate elements per cubic millimeter including 84% altered polymorphonuclear neutrophils, protein at 4.88 g/l, and glucose at 0.5 mmol/l (for a glycemia at 6 mmol/l); there was no germ on direct examination. high dose iv cefotaxime was started together ... | 2009 | 18951598 |
| identification of meningococcal genes necessary for colonization of human upper airway tissue. | neisseria meningitidis is an exclusively human pathogen that has evolved primarily to colonize the nasopharynx rather than to cause systemic disease. colonization is the most frequent outcome following meningococcal infection and a prerequisite for invasive disease. the mechanism of colonization involves attachment of the organism to epithelial cells via bacterial type iv pili (tfp), but subsequent events during colonization remain largely unknown. we analyzed 576 n. meningitidis mutants for the ... | 2009 | 18936183 |
| baseline characteristics and prevalence of hpv 6, 11, 16, 18 in young german women participating in phase iii clinical trials of a quadrivalent hpv (6/11/16/18) vaccine. | as limited data among german women exist about hpv, chlamydia trachomatis (ct) and neisseria gonorrhoeae, we report the prevalence of these genital infections and general baseline demographics of the young german women enrolled in the phase iii trials of the quadrivalent hpv vaccine. | 2009 | 18936950 |
| factor h-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide ll-37. | factor h-binding protein (fhbp; gna1870) is one of the antigens of the recombinant vaccine against serogroup b neisseria meningitidis, which has been developed using reverse vaccinology and is the basis of a meningococcal b vaccine entering phase iii clinical trials. binding of factor h (fh), an inhibitor of the complement alternative pathway, to fhbp enables n. meningitidis to evade killing by the innate immune system. all fhbp null mutant strains analyzed were sensitive to killing in ex vivo h ... | 2009 | 18852235 |
| phase ii meningococcal b vesicle vaccine trial in new zealand infants. | a tailor-made serogroup b outer membrane vesicle vaccine was evaluated in the context of a serogroup b meningococcal epidemic dominated by neisseria meningitidis strain b:4:p1.7b,4. | 2009 | 18838420 |
| outbreak of meningococcal disease in and around new delhi, india, 2005-2006: a report from a tertiary care hospital. | the first of several cases of meningococcal meningitis was reported in april 2005, in new delhi, india. subsequent to this the government declared an outbreak, which persisted for two periods, from april-july 2005 and january-march 2006. the national institute of communicable diseases (nicd) recommended using who criteria for diagnosis of disease. during the outbreak 380 clinically suspected cases were investigated. of 55 cases diagnosed as confirmed/probable the mortality rate was 14.6%. mening ... | 2009 | 18840317 |
| evaluation of the activity of 16 medicinal plants against neisseria gonorrhoeae. | 50% ethanolic extracts of various parts of 16 medicinal plants were evaluated for potential activity against clinical isolates and who strains of neisseria gonorrhoeae, including multidrug-resistant (mdr) strains. activity was calculated as percentage inhibition in comparison with penicillin and ciprofloxacin and strains were categorised as less sensitive, sensitive or highly sensitive to the extracts. the extracts caused differential inhibition of n. gonorrhoeae, with greater inhibition of the ... | 2009 | 18819776 |
| confirmation of bd probetec neisseria gonorrhoeae reactive samples by gen-probe aptima assays and culture. | use of nucleic acid amplification tests (naats), such as strand displacement assay (sda), for the detection of gonococcal infection in low prevalence populations is controversial because of the likelihood of false positive results. use of supplementary naats with alternative target sites has been recommended for confirmation of primary naat results. | 2009 | 18829626 |
| the ecological proportion of indigenous bacterial populations in saliva is correlated with oral health status. | to obtain deeper insights into the etiology of oral disease, an understanding of the composition of the surrounding bacterial environments that lead to health or disease is required, which is attracting increasing attention. in this study, the bacterial compositions in the saliva of 200 subjects aged 15-40 years were depicted as peak patterns by terminal restriction fragment length polymorphism (t-rflp) analysis of 16s rrna genes. the subjects were classified into three clusters by partitioning ... | 2009 | 18830275 |
| an unusual cause of acute polyarticular arthritis. | 2009 | 18832545 | |
| profiles of structural heterogeneity in native lipooligosaccharides of neisseria and cytokine induction. | fine differences in the phosphorylation and acylation of lipooligosaccharide (los) from neisseria species are thought to profoundly influence the virulence of the organisms and the innate immune responses of the host, such as signaling through toll-like receptor 4 (tlr4) and triggering receptor expressed on myeloid cells (trem). maldi time-of-flight (tof) mass spectrometry was used to characterize heterogeneity in the native los from neisseria gonorrheae and n. meningitidis. a sample preparation ... | 2009 | 18832773 |
| determining risk markers for gonorrhea and chlamydial infection and reinfection among adolescents in public high schools. | in response to high adolescent rates of chlamydia trachomatis (ct) and neisseria gonorrhoeae (gc), philadelphia began screening in all public high schools in 2003. | 2009 | 18813031 |
| nod2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial cns pathogens. | while glial cells are recognized for their roles in maintaining neuronal function, there is growing appreciation that resident central nervous system (cns) cells initiate and/or augment inflammation following trauma or infection. we have recently demonstrated that microglia and astrocytes constitutively express nucleotide-binding oligomerization domain-2 (nod2), a member of the novel nucleotide-binding domain leucine-rich repeat region containing a family of proteins (nlr) that functions as an i ... | 2009 | 18803303 |
| a common gene pool for the neisseria feta antigen. | meningococcal feta is an iron-regulated, immunogenic outer membrane protein and vaccine component. the most diverse region of this protein is a previously defined variable region (vr) that has been shown to be immunodominant. in this analysis, a total of 275 neisseria lactamica isolates, collected during studies of nasopharyngeal bacterial carriage in infants, were examined for the presence of a feta gene. the feta vr nucleotide sequence was determined for 217 of these isolates, with feta appare ... | 2009 | 18718812 |
| an unusual case of gonococcal arthritis of the finger. | gonococcal arthritis is the most common acute septic arthritis in sexually active young adults. it is caused by the gram-negative diplococcus neisseria gonorrhoeae. in 0.5-3% an untreated mucosal infection disseminates throughout the system and affects mostly big joints like the knee, elbows, and ankles. n. gonorrhoeae is a fragile microorganism which is difficult to culture. penicillin resistance has developed worldwide in recent years, therefore, patients should be treated by a third generatio ... | 2009 | 18719929 |
| the dape-encoded n-succinyl-l,l-diaminopimelic acid desuccinylase from haemophilus influenzae contains two active-site histidine residues. | the catalytic and structural properties of the h67a and h349a dape-encoded n-succinyl-l,l-diaminopimelic acid desuccinylase (dape) from haemophilus influenzae were investigated. on the basis of sequence alignment with the carboxypeptidase from pseudomonas sp. strain rs-16, both h67 and h349 were predicted to be zn(ii) ligands. the h67a dape enzyme exhibited a decreased catalytic efficiency (180-fold) compared with wild-type (wt) dape towards n-succinyldiaminopimelic acid. no catalytic activity w ... | 2009 | 18712420 |
| are antisperm antibodies really associated with proven chronic inflammatory and infectious diseases of the male reproductive tract? | it is debated whether chronic urogenital inflammations and infections may trigger the formation of antisperm antibodies (asa) in semen. | 2009 | 18715698 |
| molecular surveillance of neisseria meningitidis capsular switching in portugal, 2002-2006. | neisseria meningitidis capsular switching has been reported in several countries. in order to establish the genetic relationship within group b and c strains expressing subtypes 2a or 2b, and to evaluate whether c to b capsular switching occurred in portugal, 64 meningococci (56 serogroup c and 8 serogroup b) isolated from invasive meningococcal disease were typed using molecular methods. the studied phenotypes, 2b:p1.5,2 and 2a:p1.5-1,10-8, were the most frequent among serogroup c, but were unc ... | 2009 | 18667108 |
| does douching increase risk for sexually transmitted infections? a prospective study in high-risk adolescents. | the objective of the study was to examine the association between douching and 4 sexually transmitted infections (stis). | 2009 | 18667177 |
| the burden and determinants of hiv and sexually transmitted infections in a population-based sample of female sex workers in goa, india. | interventions targeting sex workers are central to the national aids control programme of india's third 5-year plan. understanding the way in which societal and individual factors interact to shape sex workers' vulnerability would better inform interventions. | 2009 | 18684856 |
| meningococcal meningitis in mali: a long-term study of persistence and spread. | meningococcal meningitis (mm) is still a huge threat in the african meningitis belt. to fight against epidemics, a strengthened health information system, based upon weekly collected data, was set up in mali. we aimed to study the spatio-temporal dynamics of mm in this country between 1992 and 2003. | 2009 | 18674942 |
| recognition of meningococcal molecular patterns by innate immune receptors. | the innate immune system plays an important role in mounting a protective immune response against invading pathogens. by presenting antigens to the acquired immune system and chaperoning the activation of b- and t-lymphocytes it determines the course of immune activation. protective immunity against neisseria meningitidis is rather well characterized and based on the presence of anti-meningococcal antibodies capable of activating the complement system. however, the activation patterns in innate ... | 2009 | 18706860 |
| a randomized controlled trial for reducing risks for sexually transmitted infections through enhanced patient-based partner notification. | we sought to assess the effectiveness of approaches targeting improved sexually transmitted infection (sti) sexual partner notification through patient referral. | 2009 | 18556619 |
| conjunctivitis secondary to neisseria meningitidis: a potential vertical transmission pathway. | 2009 | 18599878 | |
| dengue-4 envelope domain iii fused twice within the meningococcal p64k protein carrier induces partial protection in mice. | a vaccine against dengue virus must be able to induce an effective and equivalent immune response to the four viral serotypes; however, some studies have revealed that den4 (dengue-virus serotype 4) induces a weaker immune response than the others in quadrivalent (tetravalent') formulations. we have previously reported the protective capacity, in a viral encephalitis murine model, of fusion protein p64k-envelope domain iii of den1, den2 and den3. we also reported that the p64k protein can be use ... | 2009 | 18636968 |
| neisseria meningitidis: epidemiology, treatment and prevention in adolescents. | neisseria meningitidis has been recognized as a cause of serious disease for centuries, but changing epidemiology and advances in treatment and prevention strategies mandate that providers be aware of ongoing developments with regard to this infection. given the high burden of disease in adolescents, it is important for clinicians to be familiar with current recommendations regarding n. meningitidis. | 2009 | 19421058 |