Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| lack of kaposi's sarcoma-associated virus (kshv) and detection of human herpes virus 6 and 7 by pcr in african burkitt's lymphoma from hiv-negative patients. | 1999 | 10534180 | |
| presence of human herpesviruses 6, 7, and 8 dna sequences in normal brain tissue. | the three novel human herpesviruses (hhv) 6, 7, and 8 are predominantly, but not exclusively, lymphotropic. in an attempt to elucidate their neurotropism in vivo, viral dna sequences present in fresh autopsy cortical brain tissues obtained from 84 consecutive chinese subjects (mean age, 66.9 years; range, 21-98 years) were detected by a nested polymerase chain reaction. these patients were apparently immunocompetent and free of clinical signs of viral diseases. hhv-6 dna was detected in 36 of 84 ... | 1999 | 10534731 |
| penile intraepithelial neoplasia overlying kaposi's sarcoma lesions: role of viral synergy? | several viral agents have been detected in the lesional tissue of kaposi's sarcoma (ks). their precise oncogenic role remains to be determined. a 32-year-old heterosexual man with acquired immunodeficiency syndrome (aids) who had penile lesions of ks with overlying epithelial changes characteristic of intraepithelial neoplasia associated with concurrent infection by human papillomavirus (hpv) and human herpesvirus 8 (hhv-8) is reported. the absence of viral dna from uninvolved skin suggests that ... | 1999 | 10535584 |
| infection, immunity, and cancer. | a significant percentage of human cancers worldwide are associated with infections due to known viruses, including human papillomaviruses (cervical cancer and other skin cancers), human t-lymphotropic viruses (adult t-cell leukemias and lymphomas in endemic areas), hepatitis b virus (liver cancer), and epstein-barr virus (burkitt lymphoma and nasopharyngeal carcinoma). the fraction of human cancers attributable to infection may now need to be revised in light of the fact that new viral associati ... | 1999 | 10539899 |
| kaposi's sarcoma-associated herpesvirus-encoded g protein-coupled receptor activation of c-jun amino-terminal kinase/stress-activated protein kinase and lyn kinase is mediated by related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2. | the kaposi's sarcoma-associated herpesvirus (kshv) (also known as human herpesvirus 8) has been implicated in the pathogenesis of kaposi's sarcoma and b cell primary effusion lymphomas. kshv encodes a g protein-coupled receptor (gpcr) that acts as an oncogene and constitutively activates two protein kinases, c-jun amino-terminal kinase (jnk)/stress-activated protein kinase (sapk) and p38 mitogen-activated protein kinase. it also induces the production of vascular endothelial growth factor. these ... | 1999 | 10542211 |
| gene expression from the orf50/k8 region of kaposi's sarcoma-associated herpesvirus. | the orf50 gene of kaposi's sarcoma (ks)-associated herpesvirus, or human herpesvirus 8 (kshv), activates viral replication and is weakly homologous to the herpesvirus family of r transactivators; therefore, the transcription and translation events from this region of kshv are key events in viral reactivation. we demonstrate that orf50 is expressed in a bicistronic message after induction of the viral lytic cycle. orf50 migrated as a series of polypeptides: the major ones as 119 and 101 kda, resp ... | 1999 | 10544116 |
| [poems syndrome (polyneuropathy, organomegaly , endocrinopathy, monoclonal gammopathy, skin changes), multicentric castleman disease, renal chromophobe carcinoma and herpes virus type 8 infection]. | 1999 | 10544776 | |
| interleukin 1beta induces expression of human herpesvirus 8 encoded genes in bcbl-1 cells. | 1999 | 10546878 | |
| prevalence of human herpesvirus 8 infection before the acquired immunodeficiency disease syndrome-related epidemic of kaposi's sarcoma in east africa. | 1999 | 10547397 | |
| expression of potentially oncogenic hhv-8 genes in an ebv-negative primary effusion lymphoma occurring in an hiv-seronegative patient. | primary effusion lymphoma (pel) is a novel lymphoproliferative disorder associated with human herpesvirus 8 (hhv-8) infection. most pels develop in hiv-seropositive individuals and are nearly always positive for epstein-barr virus (ebv), a finding which obscures the role of hhv-8 in lymphomagenesis. however, rare ebv-negative pel cases occurring in hiv-seronegative patients have been reported, suggesting that hhv-8 may be pathogenetic by itself. to investigate whether hhv-8 may contribute to pel ... | 1999 | 10547588 |
| kaposi's sarcoma-associated herpesvirus and sexual transmission of cancer risk. | the epidemiology of aids-related kaposi's sarcoma (ks) predicted that a nonubiquitous sexually transmitted agent was central to its etiology. an assessment of hill's criteria for causality reveals there is now sufficient evidence to declare kaposi's sarcoma-associated herpesvirus (kshv), or human herpesvirus 8, a necessary, albeit not sufficient, cause of ks. the most compelling evidence comes from longitudinal studies presented in the past year that demonstrate that kshv infection temporally pr ... | 1999 | 10550016 |
| cytokines in the evolution and treatment of aids-lymphoma. | aids-lymphoma is a heterogeneous disease that most likely results from the complex interaction of several contributing factors, including chronic antigenic activation of b lymphocytes, dysregulated cytokine and co-stimulatory networks, infection with potentially oncogenic viruses (human herpesvirus-8 [hhv-8], epstein-barr virus), and accumulation of secondary genetic mutations. cytokines are believed to play an important role in the immunologic decline that favors opportunistic infection and mal ... | 1999 | 10550017 |
| motility induced by human immunodeficiency virus-1 tat on kaposi's sarcoma cells requires platelet-activating factor synthesis. | in the present study, we evaluated whether motility of kaposi's sarcoma (ks) spindle cells induced by hiv-1 tat protein is dependent on the synthesis of platelet-activating factor (paf). the results obtained indicate that tat induced a dose-dependent synthesis of paf from ks cells at a concentration as low as 0.1 ng/ml. paf production started rapidly after tat stimulation, peaking at 30 minutes and declining thereafter. tat-induced cell migration was also a rapid event starting at 30 minutes. th ... | 1999 | 10550329 |
| anti-endothelial cell auto-antibodies in hepatitis c virus mixed cryoglobulinemia. | hepatitis c virus (hcv) infection is often associated with mixed cryoglobulins (mc) and may manifest as small-vessel vasculitis. it has been suggested that antibody (ab) or sensitized t cells to hcv-containing endothelial cells may initiate the vasculitis process. anti-endothelial cell antibodies (aeca) have been found in various connective tissue disorders, with a high prevalence in systemic vasculitis. the aim of the study was to determine the prevalence of aeca in hcv patients with or without ... | 1999 | 10551381 |
| azidothymidine and interferon-alpha induce apoptosis in herpesvirus-associated lymphomas. | lymphoproliferative diseases that occur in immunocompromised patients are frequently associated with herpesviruses. these patients often fare poorly after treatment with conventional chemotherapy. we reported previously that patients with aids-related burkitt's lymphoma (bl) responded to parenteral azidothymidine (azt) and ifn-alpha. we found that ebv-positive lymphoma cells derived from these patients cultured with azt express cd95 and undergo apoptosis. azt-mediated apoptosis was caspase depen ... | 1999 | 10554028 |
| posttransplantation plasmacytic proliferations related to kaposi's sarcoma-associated herpesvirus. | kaposi's sarcoma-associated herpesvirus (kshv), which was originally detected in kaposi's sarcoma, also has been found in primary effusion lymphomas (pels) and some cases of multicentric castleman's disease. we describe two transplant recipients who developed kaposi's sarcoma and a spectrum of non-neoplastic lymphoproliferative disorders that show pronounced plasmacytic and plasmacytoid features. the first patient had recurrent pleural effusions and castleman's disease-like changes in lymph node ... | 1999 | 10555008 |
| seroprevalence of human herpesvirus-8 (hhv-8) in countries of southeast asia compared to the usa, the caribbean and africa. | seroprevalence of hhv-8 has been studied in malaysia, india, sri lanka, thailand, trinidad, jamaica and the usa, in both healthy individuals and those infected with hiv. seroprevalence was found to be low in these countries in both the healthy and the hiv-infected populations. this correlates with the fact that hardly any aids-related kaposi's sarcoma has been reported in these countries. in contrast, the african countries of ghana, uganda and zambia showed high seroprevalences in both healthy a ... | 1999 | 10555764 |
| latent nuclear antigen of kaposi's sarcoma-associated herpesvirus interacts with ring3, a homolog of the drosophila female sterile homeotic (fsh) gene. | kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) is the likely infectious cause of kaposi's sarcoma, primary effusion lymphoma, and some cases of multicentric castleman's disease. its latent nuclear antigen (lana) is expressed in the nuclei of latently infected cells and may play a role in the persistence of episomal viral dna in dividing cells. here we report that lana interacts with ring3, a nuclear protein and member of the drosophila fsh (female sterile homeotic) family of proteins, some ... | 1999 | 10559289 |
| experimental infection of rhesus and pig-tailed macaques with macaque rhadinoviruses. | the recognition of naturally occurring rhadinoviruses in macaque monkeys has spurred interest in their use as models for human infection with kaposi sarcoma-associated herpesvirus (human herpesvirus 8). rhesus macaques (macaca mulatta) and pig-tailed macaques (macaca nemestrina) were inoculated intravenously with rhadinovirus isolates derived from these species (rhesus rhadinovirus [rrv] and pig-tailed rhadinovirus [prv]). nine rhadinovirus antibody-negative and two rhadinovirus antibody-positiv ... | 1999 | 10559350 |
| human immunodeficiency virus replication in a primary effusion lymphoma cell line stimulates lytic-phase replication of kaposi's sarcoma-associated herpesvirus. | human immunodeficiency virus (hiv) and kaposi's sarcoma-associated herpesvirus (kshv) coinfect many individuals in north america and in parts of africa. infection with hiv is a leading risk factor for the development of kaposi's sarcoma (ks). in this study, we tested the hypothesis that hiv infection of common or adjacent cells would stimulate replication and spread of kshv. infection of a primary effusion lymphoma cell line by vesicular stomatitis virus type g-pseudotyped hiv type 1 led to a ra ... | 1999 | 10559351 |
| the latency-associated nuclear antigen tethers the kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells. | viruses that establish latent infection must maintain their dna in the host nucleus through many cellular generations. here we identify a novel mechanism by which the gammaherpesvirus kaposi's sarcoma-associated herpesvirus (kshv) may achieve this persistence in latently infected body cavity-based lymphoma (bcbl) cells. we find that kshv genomic dna is associated with host chromosomes and colocalizes with the latency-associated nuclear antigen (lana). furthermore, a region at the left end of the ... | 1999 | 10562490 |
| unilateral angiolymphoid hyperplasia with eosinophilia involving the left arm and hand. | a case report of recurrent angiolymphoid hyperplasia with eosinophilia (alhe) in an otherwise healthy 20-year-old female with manifestation of the disease limited to the left arm and hand is presented together with brief evaluation of the literature as well as the features distinguishing alhe and kimura's disease. immunohistochemical investigations support the hypothesis that alhe represents a reactive inflammatory lesion rather than a benign vascular neoplasm. a viral cause of alhe (e.g., hhv8 ... | 1999 | 10563499 |
| kshv-encoded viral il-6 activates multiple human il-6 signaling pathways. | kaposi's sarcoma-associated herpesvirus (kshv or hhv8) encodes a structural and functional homologue of human il-6 called viral il-6 (vil-6). expression of vil-6 in kshv-related lymphoproliferative disorders has been implicated in their pathogenesis. vil-6 has been shown to mimic a number of il-6 activities including stimulating the growth of il-6 dependent cell lines and activating the jak1 and stat1/3 pathway in hepg2 cells. however, il-6 and vil-6 display differences in receptor usage that ma ... | 1999 | 10566591 |
| the human herpesvirus-8 orf 57 gene and its properties. | human herpesvirus-8 (hhv-8) is a gamma(2) lymphotropic herpesvirus associated with kaposi's sarcoma, a major neoplasm of aids patients, and with other aids-related neoplasms. the hhv-8 orf 57 gene is conserved throughout the herpesvirus family and has a herpes simplex virus type 1 homologue, ie63 (also termed icp27), which is an essential regulatory protein and acts at both transcriptional and post-transcriptional levels. we show that, contrary to the published hhv-8 sequence, which predicts a p ... | 1999 | 10567653 |
| [cancer in organ transplanted patients]. | the risk of cancer in organ transplant recipients is three to five times higher than in the general population. the increased risk seems to be related to the total amount of immunosuppressive agents received. organ transplant recipients do not have a significantly higher risk of developing the most common types of cancer, such as cancer of the breast, lungs, prostate or the uterine body. non-melanoma skin cancers constitute well over 50% of all cancers in transplant recipients. some forms of can ... | 1999 | 10574060 |
| type i consensus ifn (ifn-con1) gene transfer into kshv/hhv-8-infected bcbl-1 cells causes inhibition of viral lytic cycle activation via induction of apoptosis and abrogates tumorigenicity in scid mice. | in this study, we investigated the effects of human type i consensus interferon (ifn-con1) (amgen) gene transfer into body cavity-based lymphomas (bcbl)-1 cells, which are latently infected with kaposi's sarcoma-associated herpesvirus (kshv) human herpesvirus-8 (hhv-8). both the basal and 12-o-tetradecanoyl phorbol-13-acetate (tpa)-stimulated production of kshv/hhv-8 mature virions was strongly inhibited in genetically modified ifn-producing bcbl-1 cells as compared with parental or control tran ... | 1999 | 10574624 |
| viruses, cancer and aids. | patients with aids are at risk of lymphoma and kaposi's sarcoma. these tumours are associated with the gamma herpesviruses, epstein-barr virus (ebv) and human herpesvirus 8 (hhv-8), although a proportion of aids lymphomas lacks both viruses. ebv and hhv-8 are latent in the tumour cells, with genes that play a direct role in driving cell proliferation. human immunodeficiency virus, in contrast, while being the greatest risk factor for lymphoma and kaposi's sarcoma, acts indirectly, mainly by caus ... | 1999 | 10575133 |
| [12th congress of virology of versailles-le chesnay. 20, 21 may 1999]. | 1999 | 10577288 | |
| oral infections and other manifestations of hiv disease. | oral lesions are important in the clinical spectrum of hiv/aids, arousing suspicion of acute seroconversion illness (aphthous ulceration and candidiasis), suggesting hiv infection in the undiagnosed individual (candidiasis, hairy leukoplakia, kaposi's sarcoma, necrotizing ulcerative gingivitis), indicating clinical disease progression and predicting development of aids (candidiasis, hairy leukoplakia), and marking immune suppression in hiv-infected individuals (candidiasis, hairy leukoplakia, ne ... | 1999 | 10579114 |
| human herpesvirus-8-encoded lna-1 accumulates in heterochromatin- associated nuclear bodies. | subnuclear distribution of the human herpesvirus-8 (hhv-8)- encoded nuclear protein lna-1 was analysed at high resolution in body cavity (bc) lymphoma-derived cell lines, in cell hybrids between bc cells and various human and mouse cells and in freshly infected k562 and ecv cell lines. three-dimensional reconstruction of nuclei from optical sections and quantitative analysis of the distribution of lna-1 fluorescence in relation to chromatin showed that lna-1 associates preferentially with the bo ... | 1999 | 10580050 |
| no evidence for a role of human herpesvirus type 8 in sarcoidosis: molecular and serological analysis. | the aim of this study was to analyse the association between human herpesvirus type 8 (hhv8) and sarcoidosis. using nested polymerase chain reaction (pcr), we tested the presence of hhv8 dna sequences in 13 skin specimens and peripheral blood mononuclear cells from eight patients suffering from sarcoidosis. we also looked for the presence of hhv8 antibodies in the sera of 28 patients with sarcoidosis using three techniques: two indirect immunofluorescence assays and an enzyme-linked immunosorben ... | 1999 | 10583053 |
| human herpesvirus type 8 is not detected in cutaneous lesions of sarcoidosis. | 1999 | 10583149 | |
| lack of evidence of human herpesvirus 8 dna sequences in hiv-negative patients with systemic plasmacytosis. | 1999 | 10583194 | |
| presence of human herpesvirus 8 dna sequences in renal transplantation-associated pleural kaposi sarcoma. | to describe one case of symptomatic skin and pleural kaposi sarcoma (ks) associated with kidney transplantation. diagnosis was supported by morphologic study and human herpesvirus 8 (hhv-8) detection in both tissues. pulmonary involvement was not present. | 1999 | 10583934 |
| [cutaneous complications after organ transplant]. | frequent diverse complications: skin problems in organ recipients mainly result from the induced immunosuppression but also from specific adverse effects of immunosuppressive drugs. the degree of extension and gravity of the clinical manifestations are often proportional to the intensity and/or duration of the immunosuppressive therapy. immunodepression mainly leads to infectious and neoplastic complications. infections: viral and fungal infections are the most frequently encountered. herpes sim ... | 1999 | 10584119 |
| spectrum of opportunistic infections and malignancies in patients with human immunodeficiency virus infection in south korea. | to determine the frequency and types of major opportunistic diseases in patients with hiv infection in south korea, we reviewed the medical records of 173 hiv-infected patients. the patients were seen from 1985 to 1998 at a referral hospital for aids in south korea. most patients (85%) were male, and 107 (62%) were infected by heterosexual contacts. cd4+ lymphocyte counts at presentation were <200/microl in 27% of the patients. tuberculosis was the most frequent opportunistic infection (25% of p ... | 1999 | 10585807 |
| detection of human herpesvirus 8 in cervical cells of chinese women with abnormal papanicolaou smears. | 1999 | 10585826 | |
| human interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant b lymphocytes. | human interleukin-6 (hil-6) acts as a growth factor in several human b lymphoid cancers. as human herpesvirus-8 (hhv-8) encodes for a viral il-6 (vil-6), the viral cytokine may be responsible for several manifestations of hhv-8-related disorders. using an anti-hil-6 mab (b-e8) which does not recognize vil-6, we investigated the involvement of the human cytokine in the proliferation of hhv-8-positive primary effusion lymphoma (pel) cells. in vitro, 5/5 pel cell lines produced hil-6 (4 to 1,200 pg ... | 1999 | 10586116 |
| enhanced in vivo human immunodeficiency virus-1 replication in the lungs of human immunodeficiency virus-infected persons with pneumocystis carinii pneumonia. | the relationship of serum human immunodeficiency virus-1 (hiv-1) rna levels to hiv-1 rna levels in other compartments, such as the lungs, is not well characterized. the purpose of this study was to determine the viral burden of hiv-1 in the lungs by comparing hiv-1 rna in cell-free bronchoalveolar lavage fluid (balf) with that in serum. specimens were examined from 77 hiv-seropositive adults (cd4(+) cell counts: 0 to 700 cells/mm(3); 48% receiving prescribed antiretroviral agents), comprising 43 ... | 1999 | 10588627 |
| role of vascular endothelial growth factor/vascular permeability factor in the pathogenesis of kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphomas. | primary effusion lymphomas (pels), which are rare lymphomas associated with kaposi's sarcoma-associated herpesvirus (or human herpesvirus-8) infection, present as malignant lymphomatous effusions in body cavities. because pels prefer liquid growth, we hypothesized that increased vascular permeability would be required for effusions to form. we found that the pel cell lines bc-1, bcp-1, and bcbl-1 produce high levels of vascular endothelial growth factor/vascular permeability factor (vegf/vpf). r ... | 1999 | 10590069 |
| human herpesvirus 8 and epstein barr-virus in a cutaneous b-cell lymphoma and a malignant cell line established from the blood of an aids patient. | human herpesvirus 8 (hhv-8) has been consistently associated with primary effusion lymphoma (pel or body-cavity-based lymphoma) but not with other lymphomas. this paper reports on an aids patient without obvious malignant effusion in body cavities but with a cutaneous lymphoma where hhv-8 and epstein-barr virus (ebv) were detected by pcr and electron microscopy. both viruses were also detected in all the cells of a malignant cell line (bbg1) established from the patient's peripheral blood mononu ... | 1999 | 10706463 |
| [human herpesvirus 8 (hhv-8)]. | human herpesvirus 8 (hhv-8) is associated with all epidemiological forms of kaposi's sarcoma (ks), multicentric castleman's disease and primary effusion lymphomas. hhv-8 is a gamma herpesvirus and his genome consists of an estimated 140 kb long unique coding region. sero-epidemiologic studies support the findings that infection by hhv-8 in the occidental countries is not ubiquitous. the main routes of transmission for hhv-8 is sexual contact at least in homo-sexual men, however distribution of t ... | 1999 | 10731808 |
| kaposi's sarcoma of the pancreas mimicking pancreatic cancer in an hiv-infected patient. clinical diagnosis by detection of hhv 8 in bile and complete remission following antiviral and cytostatic therapy with paclitaxel. | diagnosis of pancreatic cancer is usually made by endoscopic retrograde cholangiopancreatography (ercp) and corresponding findings in computed tomography (ct) or magnetic resonance imaging. kaposi's sarcoma, a frequent tumor in individuals with a late-stage hiv infection, can be located in the gastrointestinal tract and cause identical symptoms to carcinoma of the same site. a close correlation of this tumor to human herpes virus 8 (hhv 8) has been known for several years and there are reports o ... | 1999 | 10732297 |
| oral ulcers in aids patients frequently associated with cytomegalovirus (cmv) and epstein-barr virus (ebv) infections. | oral ulcers are common in aids patients, with a wide spectrum of underlying causes, including different viruses. in the present study, the presence of cytomegalovirus (cmv), epstein-barr virus (ebv) and human herpesvirus-8 (hhv-8) dna was analysed in 21 biopsies from oral ulcers of 17 male homosexual aids patients. the methods used were in situ hybridization (ish) and the polymerase chain reaction (pcr) with subsequent non-radioactive southern blot hybridization to confirm the specificity of pcr ... | 1999 | 10226942 |
| detection of human herpesvirus 8 in cervicovaginal secretions and seroprevalence in human immunodeficiency virus type 1-seropositive and -seronegative women. | epidemiologic studies suggest that human herpesvirus 8 (hhv-8) may be sexually transmitted. to study the potential for hhv-8 transmission through cervicovaginal (cv) secretions, the presence of hhv-8 dna was investigated by nested polymerase chain reaction in the cellular fraction of cv secretions from 36 human immunodeficiency virus type 1 (hiv-1)-seropositive and 29 hiv-1-seronegative women. the same patients were tested for antibodies to two defined hhv-8 antigens (latency-associated nuclear ... | 1999 | 10228077 |
| searching for human herpesvirus 8 antibodies in serum samples from patients infected with human immunodeficiency virus type 1 and blood donors from são paulo, brazil. | 1999 | 10228091 | |
| quantitation of 8 human herpesviruses in peripheral blood of human immunodeficiency virus-infected patients and healthy blood donors by polymerase chain reaction. | human herpesviruses are associated with morbidity and mortality in persons with compromised immune systems, including patients infected with human immunodeficiency virus (hiv). to investigate the basis for this association, the levels of all 8 human herpesviruses (herpes simplex virus, types 1 and 2, varicella-zoster virus, cytomegalovirus, epstein-barr virus, and human herpesvirus 6, human herpesvirus 7, and human herpesvirus 8) were measured with the quantitative polymerase chain reaction (pcr ... | 1999 | 10230356 |
| low incidence of human herpesvirus 8 in stem cell collections from myeloma patients. | human herpesvirus 8 is a gammaherpesvirus which may be implicated in the pathogenesis of multiple myeloma. viral dna sequences have been found in the bone marrow, peripheral blood and leukapheresis products of myeloma patients. these findings have significant implications for the use of leukapheresed cells in the transplantation and immunotherapy of myeloma. the studies suggest the cell which harbours the virus may be dendritic in origin. we have previously reported that dendritic cells cultured ... | 1999 | 10231136 |
| [kaposiform hhv-8 negative acroangiodermatitis in chronic venous insufficiency]. | a 76-year-old female patient developed severe manifestations of a kaposi-like acroangiodermatitis (so-called mali's disease) due to chronic venous insufficiency of the lower extremities. the patient presented with large areas of confluent, violaceous or brown-black papules on both lower legs. histologically, proliferation of thick-walled capillaries was seen in the upper dermis consisting of fully differentiated endothelial cells, as shown by immunohistochemistry. in contrast to true kaposi's sa ... | 1999 | 10231692 |
| human herpesvirus-8 (hhv-8) gene expression in kaposi's sarcoma (ks) primary lesions: an in situ hybridization study. | 1999 | 10232382 | |
| relationship of hhv8 replication and kaposi's sarcoma after solid organ transplantation. | hhv8 dna sequences have recently been isolated from all types of kaposi's sarcomas, and its association in the etiopathogenesis of this tumor has been established. however, little is known about the regulation of hhv8 replication in immunocompromised patients seropositive for this virus, and its impact on the development of kaposi's sarcoma (ks). through the study of a heart transplant patient who developed ks and in whom peripheral blood lymphocytes (pbls) had been prospectively collected befor ... | 1999 | 10232577 |
| detection of human herpesvirus-8 and epstein-barr virus dna in primary intraocular lymphomas. | 1999 | 10232895 | |
| hhv-8 is present in multiple myeloma patients. | 1999 | 10233867 | |
| kaposi's sarcoma-associated herpesvirus and multiple myeloma: lack of criteria for causality. | 1999 | 10233868 | |
| human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovir. | human herpesvirus 8 (hhv-8) sensitivity to the nucleoside analog ganciclovir (gcv) suggests the presence of a virally encoded kinase that catalyzes the initial phosphorylation of gcv. analysis of the hhv-8 genome identified two candidate kinases: proteins encoded by open reading frame (orf) 21, with homology to the herpesvirus thymidine kinases (tk), and orf 36, with homology to the herpesvirus phosphotransferases (pt). experiments presented here show that both orf 21 and orf 36 encode gcv kinas ... | 1999 | 10233939 |
| identification of the r1 oncogene and its protein product from the rhadinovirus of rhesus monkeys. | rhesus monkey rhadinovirus (rrv) is a gamma-2 herpesvirus that is most closely related to the human kaposi's sarcoma-associated herpesvirus (kshv). we have identified a distinct open reading frame at the left end of rrv and designated it r1. the position of the r1 gene is equivalent to that of the saimiri transforming protein (stp) of herpesvirus saimiri (hvs) and of k1 of kshv, other members of the gamma-2 or rhadinovirus subgroup of herpesviruses. the r1 sequence revealed an open reading frame ... | 1999 | 10233975 |
| characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8. | human herpesvirus 8 (hhv-8; also designated kaposi's sarcoma-associated herpesvirus) is the likely etiological agent of kaposi's sarcoma (ks). hhv-8 encodes a latent nuclear antigen (lna) which is the product of the viral gene orf 73. lna is recognized by most infected patient sera and is the basis of current immunofluorescence assays used in epidemiological studies of hhv-8 infection. here we describe the characterization of four monoclonal antibodies raised to the c-terminal third of lna-gluta ... | 1999 | 10233979 |
| deregulated signal transduction by the k1 gene product of kaposi's sarcoma-associated herpesvirus. | the kaposi's sarcoma (ks)-associated herpesvirus is a lymphotropic virus strongly implicated in the pathogenesis of ks and several lymphoproliferative disorders. the ks-associated herpesvirus k1 gene encodes a transmembrane protein bearing a functional immunoreceptor tyrosine-based activation motif (itam)-like sequence; it previously has been proposed to be important in viral tumorigenesis because its expression can trigger cell proliferation in vitro and in vivo. here we show that expression of ... | 1999 | 10318948 |
| paclitaxel in the treatment of human immunodeficiency virus 1-associated kaposi's sarcoma--drug-drug interactions with protease inhibitors and a nonnucleoside reverse transcriptase inhibitor: a case report study. | to describe the pharmacokinetics of paclitaxel and to investigate the interaction potential with protease inhibitors (indinavir, ritonavir, saquinavir) and the nonnucleoside reverse transcriptase inhibitor nevirapine, for which strong theoretical indications for clinically relevant drug interactions exist. | 1999 | 10321513 |
| identification and characterization of human herpesvirus 8 open reading frame k9 viral interferon regulatory factor by a monoclonal antibody. | to identify and characterize an open reading frame (orf) in association with its mrna and a coding protein recognized by anti-human herpesvirus 8 (hhv-8) monoclonal antibody b291. | 1999 | 10225208 |
| human retroviruses: their role in cancer. | viruses are etiologically linked to approximately 20% of all malignancies worldwide. retroviruses account for approximately 8%-10% of the total. for human t-cell leukemia virus 1 (htlv-i), the viral regulatory tax gene product is responsible for enhanced transcription of viral and cellular genes that promote cell growth by stimulating various growth factors and through dysregulation of cellular regulatory suppressor genes, such as p53. after a long latent period, adult t-cell leukemia/lymphoma ( ... | 1999 | 10591085 |
| human herpesvirus 8: is it a tumor virus? | human herpesvirus 8 (hhv-8), also termed kaposi's sarcoma-associated herpesvirus, was identified in kaposi's sarcoma (ks) biopsy specimens in 1994. the epidemiological data available to date indicate a strong association of hhv-8 with ks. it appears that hhv-8 is necessary for ks development. hhv-8 dna is invariably found in all epidemiological forms of ks and primary effusion lymphomas. in contrast, hhv-8 dna is rarely found in various tumor and nontumor tissues from patient groups not at risk ... | 1999 | 10591089 |
| seroprevalence of human herpes virus 8 in different eritrean population groups. | human herpesvirus 8 (hhv-8) is associated with kaposi's sarcoma. in the us and europe, hhv-8 is believed to be mainly sexually transmitted, but reports from some african countries suggest non-sexual transmission. | 1999 | 10614853 |
| human herpesvirus-8 in lymphomatous and nonlymphomatous body cavity effusions developing in kaposi's sarcoma and multicentric castleman's disease. | human herpesvirus-8 (hhv-8) has been associated with kaposi's sarcoma, multicentric castleman's disease and primary effusion lymphoma. kaposi's sarcoma and multicentric castleman's disease patients may develop body cavity effusions that, unlike primary effusion lymphoma, are poorly characterized. to better define these effusions, pleural and peritoneal fluids derived from 12 human immunodeficiency virus-seropositive and one seronegative patients affected by kaposi's sarcoma or multicentric castl ... | 1999 | 10594287 |
| vascular endothelial growth factor-c (vegf-c) and its receptors kdr and flt-4 are expressed in aids-associated kaposi's sarcoma. | kaposi's sarcoma is characterized by clusters of spindle-shaped cells that are considered to be tumor cells and by prominent vasculature. whereas spindle cells are most likely endothelial in origin, it remains controversial whether they are of lymphatic or blood vascular derivation. to test the hypothesis that the lymphangiogenesis factor vascular endothelial growth factor-c and its receptors, kdr and flt-4, are involved in the pathogenesis of kaposi's sarcoma, we performed in situ hybridization ... | 1999 | 10594750 |
| genetic analysis of the bovine herpesvirus type 4 gene locus for the putative terminase. | the complete dna sequence of the 10-45 kbp hindiii b fragment of bovine herpesvirus type 4 (bohv-4) was determined. this fragment contains nine complete and two incomplete open reading frames (orfs), all of which are homologous to herpesvirus saimiri (hvs), kaposi's sarcoma-associated herpesvirus (hhv-8) and epstein-barr virus (ebv). particularly, the arrangement of the gene for the terminase-related protein with the two coding exons 29a/29b is conserved among all herpesviruses sequenced to date ... | 1999 | 10595416 |
| [the genomic sequences of the human herpesvirus 8 in biological samples from hiv-positive and -negative subjects in sicily]. | 1999 | 10596444 | |
| human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in hiv-negative elderly men. | human herpes virus-8 (hhv-8)-associated primary effusion lymphoma (pel) is an unusual lymphoma confined to the body cavities, which primarily affects human immunodeficiency virus (hiv)-positive men at high risk for kaposi's sarcoma (ks). we describe two hiv-negative elderly italian men, who developed pleural hhv-8-positive pel in association with other diseases (systemic hypertension, colonic carcinoma, chronic obstructive airways disease, dilated cardiomyopathy), but without ks. thoracic comput ... | 1999 | 10596717 |
| does hhv-8 have a protective role on the development of hiv encephalopathy? italian hiv-seroconversion study. | to evaluate risk factors for hiv encephalopathy and whether kaposi's sarcoma (ks) and coinfection with human herpesvirus 8 (hhv-8) protect against this disease in a cohort of hiv seroconverters. | 1999 | 10599777 |
| experimental transmission of kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) to scid-hu thy/liv mice. | kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) is a novel human lymphotropic herpesvirus linked to several human neoplasms. to date, no animal model for infection by this virus has been described. we have examined the susceptibility of c.b-17 scid/scid mice implanted with human fetal thymus and liver grafts (scid-hu thy/liv mice) to kshv infection. kshv virions were inoculated directly into the implants, and viral dna and mrna production was assayed using real-time quantitative polymerase ... | 1999 | 10601360 |
| aids-related kaposi's sarcoma: principal pathogenic mechanisms. | kaposi's sarcoma (ks) is the most common malignancy that affects patients with hiv infection. considerable progress has recently been achieved in understanding the pathogenesis of this vascular malignancy. a novel herpesvirus has been detected in ks lesions of all types, in skin-lesions of post-transplant immunosuppressed individuals and in various lymphoproliferative disorders. apart from this, the increased severity of this neoplasm in patients infected with hiv may be due to hiv-derived tat p ... | 1999 | 10606175 |
| therapy of special hiv-associated diseases: hcv-hiv-co-infection and aids-related kaposi's sarcoma - official satellite to the 7th european conference on clinical aspects and treatment of hiv-infection, october 23, 1999 in lisbon, portugal. | in the era of highly active antiretroviral therapy (haart), certain complications of hiv-disease as e.g. opportunistic infections and kaposi s sarcoma (ks) have significantly diminished. new insights in pathological pathways revealed the role of co-viruses as hhv-8 and hcv so that in our days aids-associated ks and chronical hepatitis c (chc) in hiv-infected persons can be considered as the result of opportunistic infections with hhv-8 or hcv respectively. - though the overall incidence of aids- ... | 1999 | 10611054 |
| influence of foscarnet on hiv-associated kaposi's sarcoma derived cell lines. | recent reports showed a positive therapeutic effect of foscarnet on kaposi's sarcoma (ks) in hiv-positive patients. we investigated the therapeutic effect of foscarnet on ks-derived cell lines. three ks spindle cell cultures of hiv-positive patients as well three fibroblast cell cultures of hiv-positive as hiv-negative patients were established. the influence of different foscarnet concentrations (50, 100, 200, 400, 600, 1000 microg/ml) on these cell lines were analysed. there was no significant ... | 1999 | 10611055 |
| structure and function of the cc chemokine receptor (ccr) 8. | the cc chemokine receptor (ccr) 8 belongs to the seven transmembrane-spanning receptor family and functionally responds to the eukaryotic cc chemokines i-309, thymus and activation-regulated chemokine, macrophage inflammatory protein-1 beta (mip-1b) and to the products viral mip-i and viral mip-ii of the kaposi-associated herpesvirus (hhv-8). although it has not yet been fully characterised, its restricted expression to lymphoid tissues, i.e. thymus, spleen and lymph nodes, and its abundant up-r ... | 1999 | 10611408 |
| p53 inhibition by the lana protein of kshv protects against cell death. | kaposi's sarcoma-associated herpesvirus (kshv), or human herpesvirus 8, has been implicated in the development of kaposi's sarcoma (ks) and several b-cell lymphoproliferative diseases. most cells in lesions derived from these malignancies are latently infected, and different viral gene products have been identified in association with lytic or latent infection by kshv. the latency-associated nuclear antigen (lana), encoded by open reading frame 73 of the kshv genome, is a highly immunogenic prot ... | 1999 | 10622254 |
| the role of human herpesvirus-8 in the pathogenesis of multiple myeloma. | human herpesvirus-8 has been strongly implicated in the pathogenesis of ks, bcbl, and multicentric castleman's disease. evidence for its role in the pathogenesis of multiple myeloma is accumulating. human herpesvirus-8 is detectable in the nonmalignant bone marrow dendritic cells from most myeloma patients. in addition, hhv-8 is also detected in the peripheral blood of most myeloma patients. in contrast, this virus is rarely detected in close contacts of myeloma patients, healthy individuals, or ... | 1999 | 10626142 |
| kaposi's sarcoma following malignant mesothelioma. | we report the unusual occurrence of kaposi's sarcoma following asbestos-related malignant mesothelioma, in a human deficiency virus (hiv)-negative italian man. seropositivity to human herpes virus 8 (hhv8) was documented at the time of mesothelioma diagnosis and preceded the onset of kaposi' sarcoma with a time lapse of 13 months. hhv8 dna was detected by polymerase chain reaction in lesional kaposi's sarcoma but not within mesothelioma. by immunostaining, mesothelioma cells expressed interleuki ... | 1999 | 10628804 |
| aids-related body cavity-based lymphomas, herpesvirus-8 and hiv infection: a study of seven cases. | 1999 | 10630536 | |
| human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus) infection in men receiving treatment for hiv-1 infection. | to determine the prevalence of human herpesvirus 8 (hhv-8) infection in men treated for hiv-1 infection in denver, colorado. | 1999 | 10634194 |
| detection of distinct patterns of anti-tat antibodies in hiv-infected individuals with or without kaposi's sarcoma. | patterns of antibody response to recombinant transactivator protein (hiv-1 tat) in serum samples from hiv-1-negative persons (n = 60), hiv-1-infected asymptomatic persons (n = 20), hiv-1-infected people with kaposi's sarcoma (n = 25) and of people with kaposi's sarcoma without hiv-1 infection have been analyzed. none of the healthy people had anti-tat igg in their serum. all asymptomatic patients with hiv-1 infection were anti-tat igg-positive. epitope mapping revealed that these sera have anti- ... | 1999 | 10634198 |
| [infections of the oral mucosa ii. bacterial, mycotic and viral infections]. | non-specific infections of the oral mucosa are rare; however, they may present during hiv infection in the form of gingivo-periodontal lesions. in some of these candida albicans may play a role in the pathogenesis. sexually transmitted bacterial infections such as gonorrhoea and syphilis are frequently associated with hiv infection. since penicillin resistance is frequent in gonorrhoea, the cephalosporines are mainly used for treatment. syphilis increases the risk for transmission of hiv. lues m ... | 1999 | 10643281 |
| the role of human herpesvirus 8 in the pathogenesis of kaposi's sarcoma. | human herpesvirus 8 is a novel gamma-herpesvirus that has been linked with all clinical types of ks through both dna and serologic studies. by electron microscopic, in situ hybridization, and in situ pcr studies, virus is found in tumor spindle cells, in normal-appearing endothelial cells within lesions, and in tumor-infiltrating leukocytes. the fact that most tumor cells are latently, as opposed to lytically, infected with hhv8 makes the possibility of treating ks patients with antiherpesviral ... | 1999 | 10643499 |
| castleman's disease. | castleman's disease (cd) is a rare atypical lymphoproliferative disorder whose morphology, soon after the original presentation of castleman et al., has been definitely subdivided in a hyaline vascular (hv) and plasma cell (pc) histopathological pattern, with intermediate variants. the former occurs much more frequently than the latter and is usually localized to the mediastinum or pulmonary hilum. the latter involves lymph nodes separately or in aggregations and often displays multicentricity w ... | 1999 | 10655569 |
| [a case of acquired immunodeficiency syndrome (aids) with histoplasmosis]. | fungal infection is a major opportunistic infection in aids. histoplasmosis is often seen in american aids, but only one case has been reported in japan. we report a aids case of with histoplasmosis in japan. the patient was a forty year old male living in the u.s from 1987 to 1990. he was diagnosed as candidial esophagitis in july, 1994, and human immunodeficiency virus type 1 (hiv) antibody positive led to a diagnosis of aids. he was admitted to our hospital with fever and lymphadenopathy (nec ... | 1999 | 10655685 |
| cyclin d1 expression and hhv8 in kaposi sarcoma. | human herpesvirus 8 (hhv8) appears to be the agent responsible for kaposi sarcoma. the mechanism remains undetermined but may involve cell cycle regulating genes including d type cyclins which are pivotal in cell cycle progression. recent hhv8 genetic analysis has revealed the presence of a v-cyclin which is homologous to d type cyclins. | 1999 | 10645225 |
| hiv-related malignancies: community-based study using linkage of cancer registry and hiv registry data. | for people immunosuppressed by human immunodeficiency virus (hiv), we expect an increase in cancer incidence similar to that documented in transplant patients. we examined the cancer spectrum in an hiv-infected cohort, specifically malignancies not currently associated with acquired immunodeficiency syndrome (aids), in relation to the general population. cancer incidence data for residents of harris county, texas, diagnosed between 1975 and 1994, were linked to hiv/aids registry data by soundex ... | 1999 | 10639060 |
| regression of aids-related kaposi's sarcoma following antiretroviral therapy with protease inhibitors: biological correlates of clinical outcome. | the clinical response of aids-related kaposi's sarcoma (ks) to highly active antiretroviral therapy (haart), a combination of human immunodeficiency virus type 1 (hiv-1) protease and reverse transcriptase inhibitors, was studied in 11 patients, all but one with progressive ks. cd4+ cell counts, plasma hiv-1 rna levels, and antibody titres to lytic orf65 and latency-associated human herpes virus type 8 (hhv-8) proteins were determined in sequential samples. six complete and three partial clinical ... | 1999 | 10673996 |
| [kaposi's sarcoma of eyelid and conjunctiva]. | to investigate the clinical and histopathological features of ocular adnexal kaposi's sarcoma. | 1999 | 11835817 |
| ultrastructure of kaposi's sarcoma-associated herpesvirus (kshv)/human herpesvirus-8 (hhv-8) in a primary effusion lymphoma cell line treated with tetradecanoyl phorbol acetate (tpa). | the ultrastructure of kaposi's sarcoma-associated herpesvirus (kshv)/human herpesvirus-8 (hhv-8) has not yet been fully elucidated, although some findings have been reported using primary effusion lymphoma (pel) cell lines, ks-1, harboring no epstein-barr virus (ebv) coinfection. in the present study, detailed fine structural examination of kshv/hhv-8 was performed after stimulation of the pel-derived cell line ks-1 with 12-o-tetradecanoyl-phorbol-13-acetate (tpa) in vitro. while unstimulated ks ... | 1999 | 11810431 |
| the problem with antivirals alone. | some people living with hiv/aids (phas) experience dramatic drops in viral load following use of protease inhibitor (pi) combinations. pi therapy is also credited with a decrease in other aids-related complications like cmv-retinitis, parasite-related diarrhoea, and kaposi's sarcoma. despite the encouraging results, these drugs have yet to cure aids. possible explanations for this failure include only partial suppression of hiv production by drugs, hidden reservoirs of hiv in resting t-cells or ... | 1999 | 11366774 |
| hiv eradication theory meets reality. | new anti-hiv drugs approved in the mid-1990s led researchers to believe that viral eradication was possible, and that haart could effectively cure hiv disease. that viewpoint was bolstered by the decreasing prevalence of opportunistic infections and life-threatening complications like kaposi's sarcoma and progressive multifocal leucoencephalopathy (pml). however, researchers are running into serious problems with eradicating the virus. as few as five copies of hiv in the blood will continue infe ... | 1999 | 11366779 |
| hiv may have surfaced in u.s. as early as 1969, scientist says. | indications that hiv may have entered the united states as early as 1969 were recently made after frozen tissue samples from a 15-year-old male prostitute, who died of kaposi's sarcoma in 1969, were found to be infected with a strain of hiv. these findings challenge the theory that the virus originated with monkeys, and spread to humans in africa, possibly from eating monkey meat. instead, the findings suggest the virus evolved in humans for hundreds of years before developing into the current p ... | 1999 | 11366901 |
| the trouble with tumors. | kaposi's sarcoma (ks) is a type of cancer thought to be caused by the human herpesvirus-8 (hhv-8). ks causes cancerous lesions on or beneath the skin. the disease may overpower the immune system and, in some cases, cause death. studies show that the transmission of hhv-8 is linked to sexual contact, either genital or oral, and that people cannot contract ks without first having hhv-8. the recent decrease in the number of ks cases has been attributed to the use of highly active antiretroviral the ... | 1999 | 11367167 |
| hhv-8 (kshv) is not associated with bacillary angiomatosis. | bacillary angiomatosis is a rare pseudoneoplastic angioproliferative lesion occurring in patients with aids. this condition has been associated with bartonella henselae and bartonella quintana infections. human herpesvirus 8 (hhv-8) is thought to be the causative agent of kaposi's sarcoma, a vasoproliferative neoplasm, also commonly found in patients with aids. the presence of hhv-8 in a cohort of patients with bacillary angiomatosis was investigated. | 1999 | 10748868 |
| [recently discovered herpes viruses explain the etiology of well-known diseases]. | three new members of the family of human herpesviruses (hhvs) have been identified in less than a decade, hhv 6 7 and 8. hhv-6 and hhv-7, both infecting t-lymphocytes and phylogenetically related to cytomegalovirus, were identified as causative agents of exanthema subitum. in addition, hhv-6 has been reported to manifest central nervous system tropism and to be frequently detected in normal brain tissue, but has also been associated with febrile seizures. hhv-7 has been suggested to be involved ... | 1999 | 10827485 |
| kaposi's sarcoma after renal transplantation. case reports. | immunodeficiency in transplant recipients with chronic immunosuppressive treatment may have influence to developing of virus infection diseases. this publication shows a case report kidney transplant recipient which develops kaposi's sarcoma correlated with hla typing. | 1999 | 10850593 |
| clinical management of selected oral fungal and viral infections during hiv-disease. | the purpose of this review is to describe current possibilities of management of selected fungal and viral oral opportunistic infections including oral candidiasis, herpes simplex type 1 and 2-related lesions (hsv1,2), oral hairy leukoplakia (ohl) and oral lesions associated with human papilloma viruses (hpv). less common diseases such as cytomegalovirus infection or human herpes virus type 8 associated with kaposi's sarcoma and others are not considered. in a number of instances lifelong therap ... | 1999 | 10858761 |
| late complications of heart transplantation: an 11-year experience. | advances in donor and recipient selection and postoperative management of patients undergoing a heart transplant have improved survival after cardiac transplantation; nevertheless, late complications are still the main cause of mortality. between january 1988 and march 1999, 200 heart transplants and 2 retransplants were performed at our institution. the actuarial survival rate was 84.45% at 1 month, 75.22% at 1 year, and 69.48% at 5 years. one-hundred forty-five patients reached at least 6 mont ... | 1999 | 10901481 |
| viral infections of the gastrointestinal tract. | acute gastroenteritis is common in adults. it can occur in institutional epidemics or epidemics of food-borne illness; in these cases, caliciviruses are the major cause of the condition. when acute gastroenteritis occurs in nonepidemic form, its causes are less clear. it may be due to caliciviruses or to the less common serotypes of childhood gastroenteritis viruses, such as rotavirus, astrovirus, and adenovirus. the pathogenesis of acute viral gastroenteritis is not completely understood. old e ... | 1999 | 10980963 |
| human herpesvirus 8 infections. | human herpesvirus 8 (hhv-8) or kaposi's sarcoma (ks)-associated herpesvirus is a recently identified virus that is associated with ks, multicentric castleman's disease, and body cavity-based lymphomas. ks is the most common kind of cancer in aids patients and the initial aids-defining condition in over 20% of patients. hhv-8 dna has now been detected in over 95% of ks tissue samples supporting the concept that hhv-8 has a causal role in ks. the discovery has opened new avenues for understanding ... | 1999 | 11095800 |