Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| geographical distribution of the subtype of hepatitis b surface antigen in chinese. | using the much more sensitive hemagglutination inhibition assay for subtyping of hepatitis b surface antigen (hbsag), we examined the determinants a, d, w and r in 192 from 228 hbsag positive adults who had been found after screening with reversed passive hemagglutination method. sixty-four subtypable cases were asymptomatic carriers and the remaining 128 were liver disease patients. among them there was no significant difference of the subtypes, invariably with adw as the main subtype. geograph ... | 1977 | 196971 |
| experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis b virus. | the effects of treatments with diethylnitrosamine (dena) and hepatitis b virus (hbv) on macaque monkeys were investigated by virus serology and by light and electron microscopy. the experimental groups comprised 43 newborn or juvenile cynomolgus and rhesus monkeys of both sexes. hbv neither had a carcinogenic effect nor increased the oncogenic effect of dena. however, hbv given to juvenile primates before treatment with dena resulted in subsequent gross and microscopic alterations consistent wit ... | 1977 | 198564 |
| [core and coat of the hepatitis b-virus and cytoplasmic viruslike particles in chronic hepatitis. an electron microscopic study (author's transl)]. | in the second liver biopsy material of a seropositive patient receiving immunosuppressive therapy (corticosteroid + imuran) for chronic active hepatitis (cah), intranuclear, ring-shaped, 20--25 nm in diameter non-coated particles (core) of liver cells and intracisternal filaments, 23 nm in diameter (coat) of the soft er in the "ground-glass" hepatocytes were demonstrated by electron microscopy. core-particles in the cytoplasm were seen occasionally. dane-particles could not be visualized. cytopl ... | 1977 | 200036 |
| hepatocellular carcinoma and chronic persistent hepatitis. | the morphologic type of cirrhosis that is followed most frequently by hepatocellular carcinoma is posthepatitic cirrhosis. furthermore, hb ag is detected in a high rate among cases with hepatocellular carcinoma suggesting the intimate causal relationship between hepatitis b virus and hepatocellular carcinoma. it has been considered that hepatocellular carcinoma might develop during destruction and regeneration of fully developed liver cirrhosis. however, hepatocellular carcinoma is combined with ... | 1977 | 200057 |
| viral hepatitis: enzyme assays and serologic procedures in the study of an epidemic. | an epidemic of viral hepatitis beginning in late 1975 in a residence for multiply handicapped children, recognized very early in its course, was investigated prospectively to permit comparison of enzymatic and serologic tests. thirty-three residents of the institution and 46 full- and part-time employees were studied by the immune adherence hemagglutination procedure for antibody (anti-hav) to hepatitis a virus (hav). of these, 31 residents and 37 staff members were susceptible at the beginning ... | 1977 | 201170 |
| the relationship between hepatitis b virus infection and hepatic cell carcinoma in mozambique. | hepatitis b surface antigen and antibody were sought in sera collected from patients with hepatic cell carcinoma and from healthy blood donors. the frequency of the antigen among the patients was significantly higher than that among blood donors who served as controls (p = less than .01) but no significant difference was found in estimated exposure to hepatitis b virus between hepatic cell carcinoma patients and african blood donors. however, exposure to hepatitis b virus was significantly less ... | 1977 | 202048 |
| failure to transmit human viral hepatitis types a and b to the congenitally athymic nude mouse. | 1977 | 202797 | |
| anti-hbc titer in relation to the etiological role of hepatitis b virus in primary hepatocellular carcinoma. | the antibody to hepatitis b core antigen (anti-hbc) is belived to be a marker for natural infection with hepatitis b virus (hbv). in order to study the etiological role of hbv in relation to primary hepatocellular carcinoma (phc), the anti-hbc in sera of 31 phc patients was surveyed by the immune adherence hemagglutination method which was about 10 times more sensitive than the complement fixation method. twenty two out of 31 phc cases were positive for anti-hbc (71.0%). the is a higher rate of ... | 1977 | 192028 |
| hepatitis, an occupational hazard. | 1977 | 217861 | |
| [transmission of hepatitis b virus from the mother to the infant]. | 1977 | 243551 | |
| [etiology and epidemiology of viral hepatitis]. | 1977 | 211575 | |
| immunological abnormalities associated with liver disease: cause or effect? | immunological abnormalities are demonstrable in patients with various types of liver damage. these may be (a) non-specific and unrelated to pathogenesis, e.g. auto-antibodies such as anti-nuclear factor; (b) specifically directed against liver antigens but not pathogenetic, e.g. cell mediated immune (cmi) reactions to liver antigen as seen in experimental carbon tetrachloride poisoning; (c) of such a nature as to modify the pathology produced by hepatotoxic agents, e.g. hepatitis b virus or alco ... | 1977 | 274938 |
| prevalence of antibody to hepatitits b surface antigen among staff in an edinburgh hospital. | antibody to hepatitis b surface antigen was detected by radioimmunoprecipitation in 74 (5-5%) of 1336 staff members in a large general hospital in edinburgh, in 14 (2-9%) of 480 volunteer blood donors in the area, and in 12 (6-1%) of 197 pregnant women attending for the first time at the ante-natal clinic in the hospital. rates of antibody prevalence rose with age in the sample of hospital staff and in that of the blood donors, particularly among males. on the other hand, in the ante-natal patie ... | 1977 | 264499 |
| hepatitis b prevalence within a dental student population. | in this descriptive epidemiologic study, prevalence rates of hepatitis b surface antigen (hbsag) and its antibody (anti-hbs) among fourth-year dental students and second-year dental hygiene students were found to be comparable to those of a control population and a local age-adjusted blood donor group. this observation contrasts with the rates reported for practicing dentists, especially oral surgeons, and indicates that the increased risk experienced by dentists after dental school may be attri ... | 1977 | 264921 |
| [the dentist's responsibility in the oral rehabilitation of patients with chronic kidney diseases]. | it is important that the dentist knows about disturbances of blood coagulation during and after hemo-dialysis, so that he avoids administration of platelet-inhibiting medication like aspirin and that he recognizes radiologically visible signs of insufficient dialysis in the jaws. because of the reduced protection from infections, antibiotic prophylaxis should be carried out before every dental operation, the medication of choice being penicillin. due to the high rate of infection by the hepatiti ... | 1977 | 265241 |
| partial amino acid sequence of two major component polypeptides of hepatitis b surface antigen. | determination of the amino acid sequence of the immunogenic polypeptides of hepatitis b surface antigen may not only permit molecular localization of the distinct determinants a, d, and y but may also lead to the synthesis of a hapten useful in prophylactic immunization against hepatitis b virus infection. for this purpose, purified monotypic hepatitis b surface antigen of adw subtype was resolved into equal amounts of two major polypeptides (22,000 and 28,000 daltons) and up to six other minor ... | 1977 | 266193 |
| host specificity of a serum marker for hepatitis b: evidence that "e antigen" has the properties of an immunoglobulin. | a family of antigens, referred to collectively as e antigen (eag), has been detected in sera of some individuals with liver disease who test positive for hepatitis b surface antigen. studies on eag partially purified by affinity chromatography on insolubilized antibodies to eag revealed the following: (i) eag has the physicochemical and immunologic properties of an immunoglobulin, predominantly of the igg4 subclass, and (ii) specific antigenic sites, designated as e determinants, differentiate e ... | 1977 | 266209 |
| association of e antigen with dane particle dna in sera from asymptomatic carriers of hepatitis b surface antigen. | sera containing hepatitis b surface antigen from 30 asymptomatic blood donors were assayed for e antigen (hbeag) and antibody to e antigen (anti-hbe) by rheophoresis,. fourteen samples (47%) had detectable hbeag, ten (33%) had anti-hbe, and six (20%) had neither. dna was extracted from 26 of these sera and assayed for its ability to anneal to a [32p]-dna probe that is a copy of dane particle dna. all 10 hbeag-positive samples tested contained dna that formed specific hybrids with the dna probe, ... | 1977 | 266736 |
| rebuttal to a jama editorial: hepatitis b--traffic in the dentist's office. | 1977 | 267655 | |
| sex differences in response to hepatitis b infection among patients receiving chronic dialysis treatment. | patients undergoing treatment at a community-based renal dialysis clinic were monitored monthly for hepatitis b surface antigen (hbsag) and antibody to hbsag (anti-hbs). of 160 patients who began treatment hbsag(-)/anti-hbs(-), 77 subsequently became hbsag(+). once hbsag(+), males were more likely to remain hbsag(+) indefinitely, whereas females were more likely to convert to hbsag(-) and develop anti-hbs. this was not due to a sex difference in exposure to hepatitis b virus because only patient ... | 1977 | 267950 |
| association of graft survival with host response to hepatitis b infection in patients with kidney transplants. | we studied the relation of host response to hepatitis b infection before transplantation with survival of kidney grafts in 79 patients receiving 87 transplants. antibody to hepatitis b surface antigen (anti-hbs) signaled early graft rejection (median survival congruent to two months), whereas hepatitis b surface antigen (hbsag) signaled delayed rejection (greater than 22 months). patients with neither hbsag nor anti-hbs had graft survival times (median congruent to 16 months) similar to the hbsa ... | 1977 | 318732 |
| acute and chronic hepatitis: multisystemic involvement related to immunologic disease. | 1977 | 320847 | |
| [epidemiological study of hepatitis b virus in children in the aki area, kochi-ken, japan]. | 1977 | 321837 | |
| identification of lymphocytes in percutaneous liver biopsy cores. different t:b cell ratio in hb sag-positive and -negative hepatitis. | the lymphocytes infiltrating the liver were isolated and characterized as t or b cells in three groups of patients: 20 patients with hepatitis b surface antigen (hb sag)-positive acute and chronic hepatitis, 8 patients with hbsag-negative chronic hepatitis with prior evidence for hepatitis b virus (hbv) infection, and 5 patients with hbsag-negative chronic hepatitis without prior evidence for hbv infection. the predominant cell infiltrating the liver was shown to be a t cell in all categories; h ... | 1977 | 323096 |
| [medical nobel prize in 1976]. | 1977 | 323771 | |
| vertical transmission of hepatitis-b surface antigen. | transmission of hepatitis b virus from mother to infant can cause a severe type of neonatal hepatitis. comparing chronic carrier mothers with mothers who have acute hepatitis in pregnancy we find that the latter group present the greater risk to their infants. differences in the presence of hepatitis b core and hepatitis b e antigen and antibody in the acute case and in the carrier state may expoain the differences observed in the transmission rates of two groups. in countries where the prevalen ... | 1977 | 324529 |
| antibodies to hepatitis b core antigen in hepatitis b surface antigen-positive and -negative chronic hepatitis. | antibody to hepatitis b core antigen (anti-hbc) is a sensitive indicator of hepatitis b virus (hbv) infection. however, anti-hbc has been found in only a few patients with chronic hepatitis. therefore, we tested for anti-hbc in 124 sera from 67 patients with histologically proven chronic hepatitis by the indirect fluorescent antibody technique. all patients, except for one with chronic hepatitis who was seropositive for hepatitis b surface antigen (hbs ag), had anti-hbc that persisted throughout ... | 1977 | 325149 |
| australia antigen and the biology of hepatitis b. | 1977 | 325649 | |
| [comparative study of three technics of inverse passive hemagglutination in the search for a surface antigen of the hepatitis b virus (ag hbs) (author's transl)]. | the following three different versions of reverse passive hemagglutination (rpha) were evaluated for the detection of hbs antigen: auscell i - abbott, wh hbs - wellcome and the hepanosticon - organon technique and results obtained were compared with those obtained by the radio immuno assay (ausria ii of abbott). in 493 sera studied, up to 16,8% were found positive by rpha as compared to 17,2% positives by ria. the percentage of false positives by the different methods varied from 4,9 to 7,3. con ... | 1977 | 327414 |
| [magnius' e-antigen]. | the "e" ag/ac system found by magnius in 1972 is discussed briefly. the new antigen has the same immologic and physiochemical characteristics of hbs and hbc of the hepatitis virus. its existence shows the chronic evolution of the disease in ag hbs carriers. therefore the "e" antigen has a prognostic value in ag hbs carries. | 1977 | 329074 |
| correlation between titer of antibody to hepatitis b core antigen and presence of viral antigens in the liver. | liver specimens of 31 autopsied cases of liver cirrhosis who had had detectable levels of antibody to hepatitis b core antigen (anti-hbc) inthe serum were stained for hepatitis b core antigen (hbcag) and hepatitis b surface antigen (hbsag) by the direct immunofluorescence method. their premortem serum samples were tested for hbsag, antibody to hbsag (anti-hbs) and anti-hbc. persistent hepatitis b virus (hbv) infection as judged by circulating and/or liver hb antigens was identified in 18 patien ... | 1977 | 330306 |
| eukaryotic dna polymerases. | 1977 | 332062 | |
| immune response to hepatitis b virus in children with papular acrodermatitis. | papular acrodermatitis of childhood (pac) is characterized by papular eruption of skin, lymphadenopathy, and acute hepatitis b surface antigen (hbsag)-positive anicteric hepatitis. to study the course of hepatitis b virus infection we followed 16 patients with pac, 2 to 7 years of age, for periods ranging from 6 to 46 months. all patients tested developed hepatitis b surface antigenemia subtype ay, and produced antibody to hepatitis b core antigen with the highest incidence after 3 to 5 months. ... | 1977 | 332578 |
| simultaneous presence of hbsag and anti-hbs in the serum of different subtypes (serological and immunofluorescent studies). | serological and immunofluorescent studies were performed in 3 patients with the simultaneous presence of hbsag and anti-hbs in the serum. our investigations revealed the following results: hbsag and anti-hbs in the serum were of different subtypes. hbsag in the serum and in the liver had the same subtype. hbsag in the liver did not react with the circulating anti-hbs in the patient's own serum. hbsag-anti-hbs immune complexes could not be detected in the serum or in the liver tissue. these pheno ... | 1977 | 333803 |
| hepatitis b in ward and clinical laboratory employees of a general hospital. | after a sharp increase in viral hepatitis cases, mostly type b, among the 2000 employees of a general hospital during three years, we conducted an investigation which consisted of obtaining data on employee cases and surveying many current employees. of the 38 cases, 22 occurred in non-physician, ward employees. of 189 current ward employees, 8% had antibody to hepatitis b surface antigen (anti-hbs) and 1% had hepatitis b surface antigen (hbsag). hepatitis b virus (hbv) seropositivity was highes ... | 1977 | 333905 |
| the genome of hepatitis b virus. | 1977 | 334041 | |
| enzyme immunoassay for hepatitis b and its comparison to other methods. | a solid-phase enzyme immunoassay for the qualitative detection of hepatitis b surface antigenemia is presented and the results compared to the counter-immunoelectrophoresis and radioimmunoassay methods for detection of the same antigen. the enzyme-antibody conjugate was prepared from horseradish peroxidase coupled with antibodies to three sub-types of hepatitis b virus. polystyrene plastic tubes were used as the solid-phase support. the results of the enzyme immunoassay compare favorably with ra ... | 1977 | 336244 |
| [comparison between the presence of specific circulating immune complexes and the leukocyte migration inhibition test in different clinical forms of hepatitis b]. | circulating immune complexes were measured by a radioimmunoassay specific for hb complexes in different clinical situations related to hepatitis b virus infection. the leukocyte migration inhibition test (lmit) was performed simultaneously. comparison with the clinical situation suggests that immune complexes are not responsible for the lesions, but that these lesions might be produced by the immunity demonstrated by the lmit. a deficiency of this immunity is responsible for the persistence of i ... | 1977 | 337469 |
| the outcome of hepatitis b virus infection in pregnancy. | the literature concerning hepatitis b in pregnancy is reviewed and problems of management of both the acute and chronic infections are discussed. | 1977 | 339213 |
| t and b lymphocytes in uremic patients with type b hepatitis infection. | peripheral t and b lymphocytes were measured in (1) hepatitis b surface antigen (hbsag)-positive, (2) hbsag-negative uremic patients on chronic hemodialysis (chd) therapy, and (3) patients with type b chronic active viral hepatitis (cavh). when compared to normals, a decrease in the absolute number of t and b lymphocytes was detected in both chd groups. cavh patients had a decrease in the total number of t lymphocytes. when expressed as percentage of t lymphocytes, normals and hbsag-negative chd ... | 1977 | 300854 |
| [significance of the antigen and the anti-e antibody in patients with surface antigen of hepatitis b virus]. | 1977 | 302013 | |
| [maternal transmission of the hepatitis b virus (incidence and results)]. | 1977 | 342329 | |
| localisation of e-antigen in nuclei of hepatocytes in hbsag-positive liver diseases. | by the direct immunofluorescence technique 19 liver biopsies were examined for the presence of the e-antigen associated with the hepatitis b virus infection. with the use of double incubation and blocking experiments with fitc and rhodamine labelled antisera against hepatitis b core antigen and e-antigen, evidence is presented that the e-antigen is localised in the nuclei of the hepatocytes. we conclude that the e-antigen and the core antigen are not identical, although they are often present si ... | 1977 | 342357 |
| humoral and cell-mediated immunity to hepatitis b virus antigen in a haemodialysis-renal transplantation unit. | hepatitis b surface antigen (hbsag), the corresponding antibody (anti-hbs), the antibody to hepatitis b core antigen (anti-hbc), and the cellular immune response to purified hbsag (leucocyte migration inhibition test: lmt-hbsag) were determined in 19 staff members, 11 long-term haemodialysis patients, and 22 renal transplant patients in a haemodialysis-renal transplantation unit. past or present infection, as expressed by the presence of circulating anti-hbs or hbsag, was found in 30 cases (58 p ... | 1977 | 343497 |
| fluorescent antibody study of diseased, end-stage human kidneys. | forty cases of diseased kidneys at end-stage were studied by fluorescent antibody technique in search for viral etiology of glomerulonephritis and other renal diseases. among these 40 cases, 12 (30%) were ascribed to immune complex disease because of detection of immunoglobulins and complement in glomeruli of the same kidney specimen. in 8 cases (20%) only complement was detected in glomeruli. in the remaining 50% neither complement nor immunoglobulin deposit was found in glomeruli. the etiologi ... | 1977 | 357100 |
| [vaccination against hepatitis b in man]. | the preparation of a vaccine against hepatitis b is described. the vaccine is prepared from the hb viral coat (hbs ag) purified and formalin inactivated. the hbs ag is isolated and purified from the blood of healthy hbs ag positive donors by means of an immunoadsorbent technique. the inocuity and efficacy were tested on chimpanzees. vaccination was then applied in an attempt to protect patients and ward staff in a high risk haemodialysis unit. the efficacy of the vaccine was assessed by humoral ... | 1977 | 401985 |
| [use of a highly-sensitive method of electrophoresis-precipitation for detecting hepatitis b virus antigen in human serum]. | a modification of the highly-sensitive method of electrophoresis-precipitation in polyacrylamide gel used for detection of the virus hepatitis b antigen (hbsag) and the anti-hbsag is described. the method completely retains the specificity of the gel immunodiffusion test, but is 100--2000 times more sensitive in hbsag detection. the sera of patients with different pathology were checked by this method. in comparison with the methods used before the hbsag determination by the mentioned method pro ... | 1977 | 403983 |
| discordant e antigen, dna polymerase activity, and dane particle responses in two patients representing an index case-contact case pair with hepatitis b virus infection. | discordant results for e antigen, dna polymerase activity, and dane particle frequency were noted in the sera of two patients representing an index case-contact case pair with chronic aggressive hepatitis b. the lack of correlation between presence of e antigen and the infecting viral strain, as well as the strong relationship of e antigen to persistent and significant viremia, emphasize the role of the host's immune response in the expression of this antigen. | 1977 | 407311 |
| [significance of eag in hbsag positive families]. | 1977 | 407315 | |
| anti-hb immunoglobulin and its use in the prevention of hepatitis b. | 1977 | 410078 | |
| hepatitis-b surface antigen and antibody in black and white patients with venereal diseases. | the prevalence of both the hepatitis-b surface antigen (hbsag) and its specific antibody (anti-hbs) was significantly greater in the sera of white patients suffering from sexually transmitted diseases than that in white blood donors. however, black patients with venereal diseases did not show an increased prevalence of either hbsag or anti-hbs. these findings support the view that heterosexual transmission of the hepatitis-b virus is less likely to occur in populations in whom this infection is ... | 1977 | 580069 |
| [cellular immunity in 18 cirrhotic african carriers of hepatitis b virus surface antigen (hbsag)]. | the cell mediated immunity has been studied by 3 different tests on a population including 32 african patients with cirrhosis; amongst those, 18 were hbs ag carriers and 14 were hbs ag-. in those 2 groups, the intradermal tuberculin test and the dncb cutaneous test showed a striking imminutary deficiency in half cases. the lymphoblastic transformation induced by pha gave less striking results. | 1977 | 580921 |
| prognostic implications of the e antigen of hepatitis b virus. | the e antigen hbeag and its antibody anti-hb, have been said to be predictive of chronicity and resolution, respectively, in viral hepatitis. we found, as have others, a specific association with hepatitis b virus-induced disease. in addition, detectability of hbeag in the acute phase of type b hepatitis was followed by a sixfold higher incidence of chronic hepatitis. unfortunately, the prediction was erroneous in 65% of positive cases and 6% of negative cases. in chronic hepatitis, hbeag did no ... | 1977 | 578882 |
| hepatitis b surface antigen (hbsag) and antibody to hbsag. prevalence in homosexual and heterosexual men. | the prevalence rates of serum hepatitis b surface antigen (hbsag) and antibody to hbsag (anti-hbs) were 5.6% and 34% in 144 homosexual men in seattle. prevalence rates were only 0.9% and 3.6% in 111 heterosexual male venereal disease clinic patients with nongonococcal urethritis, and also 0.9% and 3.6% in 111 healthy men undergoing routine physical examinations. thus, previous exposure to hepatitis b virus (hbv) was estimated to be 8.8 times greater for homosexual men than for heterosexual men. ... | 1977 | 579199 |
| hepatitis b virus infection on taiwan. | 1977 | 757978 | |
| [permeability of dialysis membranes for hepatitis-b virus: on the prophylaxis of hepatitis in a haemodialysis centre (author's transl)]. | dialysis fluids of two hepatitis-bs (hbs) antigen-positive dialysis patients were tested for hepatitis-b virus. total dialysate volume of 5.5 litres each - as obtained on haemodialysis with the redy-recirculation system - was concentrated by ultrafiltration and trap and rate-zonal ultracentrifugation, followed by fractionation, and purified. electron-microscopic evidence of permeability of an intact dialysis membrane for hepatitis-b was obtained. concentration of hepatitis-b virus was at least 1 ... | 1977 | 830518 |
| transmission of hepatitis b virus to gibbons by exposure to human saliva containing hepatitis b surface antigen. | a pool of whole-mouth saliva collected from five human carriers of hepatitis b surface antigen, subtype adr, was found to contain antigen particles with mean diameters of 23.3 and 41.8 nm as seen by immune electron microscopy. two gibbons received subcutaneous injections of the pooled saliva and developed serological and, in at least one animal, biochemical evidence of hepatitis b virus infection at 12 and 22 weeks, respectively. although none of eight other gibbons that were exposed by the nasa ... | 1977 | 833450 |
| dna synthesized in the hepatitis b dane particle dna polymerase reaction. | radioactive dna was prepared in extensive (4 h) dane particle dna polymerase reactions. in different experiments the amount of new dna, determined by the amount of nucleotide incorporation into an acid-insoluble form, was between 29 and 45% of the total circular dna isolated from dane particle preparations after the reaction. dna reassociation kinetics were used to determine the complexity of the newly synthesized dna. in different experiments cot1/2 values, corresponding to between 625 and 1,25 ... | 1977 | 833933 |
| infectivity of purified hepatitis b virus particles. | 1977 | 834202 | |
| [new markers of hepatitis b virus. diagnostic and prognostic value]. | 1977 | 834546 | |
| distribution and persistence of hepatitis b surface antigen and antibody in a melanesian population. | the population of graciosa bay, santa cruz, british solomon islands protectorate, was tested for hbsag and anti-hbs in 1973 and 1974. both the antigen and antibody occurred more often in males, presumably due to a higher exposure rate. none of 28 infants under one year of age had antigen and only one of 50 individuals under two years (2%) did. the prevalence of antigenemia was higher in older children and did not decline with increasing age. this pattern is contrasted to that found in other popu ... | 1977 | 835561 |
| limited family clustering of hepatitis b surface antigen in a melanesian population. | the entire population of graciosa bay, santa cruz, solomon islands, was tested for hepatitis b surface antigen (hbsag) by reverse passive hemagglutination and antibody to hbsag (anti-hbs) by passive hemagglutination. analysis of the distribution of hbsag in relatives of hbsag carriers and non-carriers showed clustering only in children of carrier mothers. similarly, there was no clustering of total exposure as measured by serologic tests except in children of carrier parents primarily due to the ... | 1977 | 835562 |
| epidemiology of hepatitis b in two alaska communities. | in 1973, epidemiologic and serologic data related to hepatitis b infection were collected from the residents of two remote alaskan eskimo villages located in an area of high hepatitis incidence. a total of 418 sera were tested by solid-phase radioimmunoassay for heaptitis b surface antigen (hbsag) and antibody to that antigen (anti-hbs). the overall infection prevalence of 54.8% in the two villages included a 13.9% prevalence of hbsag and a 40.9% prevalence of anti-hbs. families containing an in ... | 1977 | 835563 |
| hepatitis and hepatitis b-antigen in greenland. ii: occurrence and interrelation of hepatitis b associated surface, core, and "e" antigen-antibody systems in a highly endemic area. | the distribution of hepatitis b surface antigen and antibody (hbsag and anti hbs), hepatitis b core antibody (anti-hbc), and the heaptitis b associated "e" antigen-antibody system (hbeag and anti-hbe) were studied in three areas in greenland previously shown to be endemic for hepatitis b. overall prevalence of hbsag and anti-hbs ranged from 47 - 81%, thus confirming the existence of a hyperendemicity of the hepatitis b agent in some polar areas. anti-hbc occurred closely correlated to hbsag and ... | 1977 | 835567 |
| viral hepatitis type b during pregnancy, the neonatal period, and infancy. | eighteen women who developed type b hepatitis late in pregnancy or early in the postpartum period (groups i and ii), 12 women who were chronically infected with the hepatitis b virus (groups iii and iv), and 32 of their offspring were tested for hepatits b surface antigen, antibody to the hepatitis b surface antigen, antibody to the hepatitis b core antigen, and the recently discovered hepatitis b-associated e antigen and its antibody. twelve of 18 infants born to group i and group ii mothers a ... | 1977 | 839328 |
| t-lymphocyte cytotoxicity to hbsag-coated target cells in hepatitis b virus infection. | the cytotoxic effect of peripheral lymphocytes on chicken red blood cells (chrbc) coated with purified hepatitis b surface antigen (hbsag) has been studied as an in vitro parameter of cell-mediated immunity in acute and chronic infection with hepatitis b virus. using this technique, the mean cytotoxic index of lymphocytes from patients with acute hepatitis b (29.13 +/- 20.88) was significantly higher than that obtained with lymphocytes from control subjects (6.53 +/- 3.75). only 33.3% of the pat ... | 1977 | 304824 |
| core antigen and circulating anti-core antibody in hepatitis b infection. | core antigen was obtained from the sera of persistent chronic carriers of hepatitis b virus by centrifugation and treatment with nonidet p40 and 2-mercaptoethanol. the separated core antigen was radiolabelled and identified as a nucleoprotein structure of buoyant density 1.36 g/cm3 and possessing an isoelectric point of 4.4. this material was employed in a radioimmunoassay procedure of high sensitivity for the detection of core antibody. in a series of sera from patients with acute type b hepati ... | 1977 | 557072 |
| [morphological alteration and desintegration of dane particles after exposure with "gigasept". a first methological attempt for the evaluation of the virucidal efficacy of a chemical disinfectant against hepatitisvirus b ( author's transl)]. | a test system based on morphological alterations and desintegration of hepatitis virus b (hbv) is presented for the approximative evaluation of the virucidal efficacy of a chemical disinfectant. dane particles, supposed to be the infectious entity of hbv, were partially purified by a trap and a rate zonal ultracentrifugation from serum samples of a patient with chronic hepatitis undergoing an immune suppressive treatment because of leukemia. "gigasept" on the basis of succine dialdehyd and forma ... | 1977 | 557269 |
| [rearing and management of chimpanzees for experimental infection with hepatitis b virus (author's transl)]. | for the purpose of experimental infection with human hepatitis b virus, 14 chimpanzees (pan troglodytes) were delivered to the division of animal research, faculty of medicine, university of tokyo, tokyo. these chimps, 11 males and 3 females, born in the west africa, had been reared for two to six months. several days after delivery, they were anesthetized with ketalar in order to make clinical, bacteriological and parasitological examinations; it was found that one of them was in malnutrition, ... | 1977 | 558103 |
| disparate response of monozygotic twins to hepatitis b virus infection. | 1977 | 559734 | |
| [late sequelae of tumor treatment in childhood: hbsag persistance and liver diseases]. | 1977 | 559930 | |
| serodiagnosis of hepatitis b virus infection by antibody to core antigen. | in a military population antibody to hepatitis b core antigen (anti-hbc) was found in 39% of acute hepatitis cases negative for hepatitis b surface antigen (hbs ag) and in 96% of hbs ag-positive cases. persistence of antibody to hbs ag (anti-hbs) in convalescent-phase sera was significantly greater (p less than 0.001) in individuals with acute hbs ag-positive hepatitis b than in patients with clinical hbs ag-negative hepatitis b. the prevalence of anti-hbc in the absence of hbs ag, anti-hbs, and ... | 1977 | 560416 |
| [hbv (hepatitis b virus) infection through the birth canal]. | 1977 | 587187 | |
| e antigen and antibody in outbreaks of hepatitis b in two renal dialysis units. | in two renal dialysis units which had outbreaks of hepatitis b, patients were studied for the presence of e antigen and antibody. in one unit, in which the illness was mild and most of the patients (78%) became carriers of hbsag, all but one patient had e antigen. most of the hbsag carriers had persisting e antigen and most of the transient patients had also transient e antigen. in the other unit, in which the illness was more severe, none of the patients became a carrier. only 30% had e antigen ... | 1977 | 599184 |
| the infant and hepatitis b virus infection. | hbv has been shown to be responsible for a broad spectrum of disease in infants although most are asymptomatic carriers with mild transaminase elevation and unresolved hepatitis on liver biopsy. maternal-infant transmission is responsible for most infections. blood product infusion should become less significant. acute maternal hepatitis in the perinatal period results in asymptomatic infant infections at rates far exceeding transmission from asymptomatic carrier mothers. carrier mothers with th ... | 1977 | 602864 |
| humoral and cell-mediated immunity to hepatitis b virus antigens in acute and chronic liver disease. | the humoral immune response to hepatitis b virus antigens and the cell-mediated immunity to hepatitis b surface antigen (hbsag) were investigated in 12 healthy persons and 56 patients with various liver diseases. in patients with acute viral hepatitis type b, anti-hepatitis b core antigen was present constantly in serum in all phases, and after clinical recovery simultaneously with anti-hbs. a transitory cellular immune response to hbsag was demonstrated at the time the antigen was cleared, whil ... | 1977 | 605351 |
| high prevalence of hepatitis b virus infection among heavy alcohol drinkers in japan. | 1977 | 611365 | |
| australia antigen--a fresh approach. | 1977 | 614407 | |
| [epidemiologic study of chronic hepatitis in relation to heptatis b virus infections (author's transl)]. | in order to evaluate the role of hepatitis b virus (hbv) in the etiology of chronic liver diseases, paired sera of 143 patients with biopsy-documented chronic hepatitis were tested for hbsag and anti-hbs by radioimmunoassay method. hbsag was detected in 67.3% of patients with a preceding verified eipsode of acute hepatitis, and in 26.7% of patients with a cryptogenic form of chronic hepatitis. hbsag was not found in any of patients with alcoholic chronic hepatitis and in only two of 18 patients ... | 1977 | 616263 |
| [hepatitis b antigen (hbsag) in hospitalized children]. | blood samples of 1940 hospitalized children aged 0--18 years were investigated for presence of hbs-ag by counter-electrophoresis, haemagglutination and radioimmunoassay, hbs-ag was found in 1.34% of all patients, being distributed evenly amongst boys and girls. the incidence was 1.7% in patients from a large university children's hospital and 0.6% in patients from a group of regional hospitals. of 26 samples positive by radioimmunoassay, 1 only was found positive by insensitive counter-electroph ... | 1977 | 617959 |
| progress with hepatitis b virus-editorial review. | 1978 | 18748146 | |
| hepatitis b virus and primary liver cancer. | 1978 | 618428 | |
| seroconversion from hepatitis b e antigen to anti-hbe in acute hepatitis b virus infection. | 1978 | 622119 | |
| hepatitis b antigen and antibody among staff members of an israeli hospital and a kibbutz population. | until recently, hepatitis type b was thought to be transmitted parenterally. however, much evidence has appeared regarding non-parenteral transmission. hospital personnel are exposed both ways to this disease. we compared the incidence of hepatitis b surface antigen (hbsag) and antibody (anti-hbs) among 388 workers at a major medical center in israel with 203 kibbutz residents, using radioimmunoassay procedures. of the hospital personnel, 1.8% were found to carry the antigen and 23.9% the antibo ... | 1978 | 622814 |
| antibody to hepatitis b core antigen in chronic active hepatitis. | antibody to hepatitis b core antigen (anti-hbc), which has been assumed to be a more sensitive indicator of hepatitis b virus replication than hepatitis b surface antigen (hbsag), was detected in the sera of 26 of our 65 patients with hbsag-negative chronic active hepatitis. thus despite the absence of hbsag the liver disease could be the consequence of chronic infection with hepatitis b virus in these patients. they differed, however, from a group of 35 patients with hbsag-positive hepatitis in ... | 1978 | 624027 |
| hepatitis b virus infections among danish dentists. | since type b hepatitis is generally regarded as an occupational risk for dentists, the participants at the 1976 annual meeting of the danish dental association were examined for hepatitis b surface antigen (hbsag) and antibody to hbsag (anti-hbs). a total of 1,338 dentists (89% of the dentists at the meeting and 29% of all danish dentists) were included in the study by completion of a questionnaire and by radioimmunoassay of a blood sample for hgsag and anti-hbs. none of the dentists was hbsag-p ... | 1978 | 624852 |
| inhibition of hepatitis b dna polymerase by intercalating agents. | 1978 | 625339 | |
| [anti-hbc within the framework of hepatitis b virus infection: correlation to the form of inflammation and to the viral expression]. | 168 hbag seropositive and 105 hbag seronegative liver biopsies were studied for correlations between anti-hbc titers (indirect immunofluorescence method) and tissue expression of hbsag and hbcag (immunofluorescence), dane particles in blood (immune electron microscopy) and inflammatory reaction. 98.8% of the hbag seropositive patients were positive for anti-hbc. the mean titers showed statistically significant differences mainly between chronic aggressive hepatitis (1:2(11.3)) versus lobular hep ... | 1978 | 625636 |
| transmission of hepatitis v virus infection by transfusion of frozen-deglycerolized red blood cells. | chimpanzees were used to determine the ability of prior freezing of red blood cells to prevent the transmission of type b post-transfusion hepatitis. four units of human whole blood were each inoculated with 10(6) infectious doses of hepatitis b virus. although all units became hbsag negative after freezing and deglycerolization, hepatitis b virus infection developed in all four chimpanzees when these units were transfused. two of these chimpanzees had only serologic evidence of infection, inclu ... | 1978 | 628386 |
| viral hepatitis. | viral hepatitis may be classified into three or more forms including type a hepatitis, type b hepatitis, and a group denoted as non-a non-b hepatitis which may represent viral hepatitis of one or more causes. the differentiation of these forms of hepatitis is primarily serologic. the development of antibody to hepatitis a virus can be detected by radioimmunoassay as well as by other test systems. the serologic diagnosis of type b hepatitis rests on the detection of hepatitis b surface antigen or ... | 1978 | 629050 |
| prevalence of hepatitis a and b infections in multiply transfused thalassaemic patients. | evidence of hepatitis b virus (hbv) and hepatitis a virus (hav) infections was south in 148 multiply transfused patients with thalassaemia and in healthy controls (2040 for hbv and 217 for hav). the prevalence of the hbv surface antigen or antibody to it was significantly higher in patients than in controls and increased with the number of blood transfusions. in contrast, the prevalence of antibody to hav was significantly lower in patients than in controls and decreased with the number of blood ... | 1978 | 630296 |
| radioimmunoassay and some properties of human antibodies to hepatitis b core antigen. | a solid-phase radioimmunoassay for antibodies to hepatitis b core antigen (anti-hbc) is described. polystyrene beads coated with anti-hbc, hepatitis b core antigen prepared from pooled sera of humans infected with hepatitis b virus (hbv) and 125i-labelled anti-hbc were used for the test. distinct patterns of development and changes of anti-hbc and their immunologic properties are all related to variations of other markers specific for hbv infections. knowledge concerning the detailed features of ... | 1978 | 632812 |
| effect of vidarabine on chronic hepatitis b virus infection. | 1978 | 633577 | |
| [immunologic diagnosis of chronic liver diseases]. | 1978 | 639653 | |
| immune response of leprosy patients to hepatitis b virus. | 1978 | 645701 | |
| hepatitis b surface antigen in human tears. | the incidence of hepatitis b virus infection has been increasing every year in the united states, particularly among medical personnel. only half of these cases are associated with exposure to blood or blood products. respiratory, fecal-oral, and venereal methods of transmission of hepatitis b virus infection are supported by epidemiological evidence and by the demonstration of hepatitis b surface (hbsag) antigen in several body secretions. in this investigation, tears were collected from patien ... | 1978 | 646696 |
| type b hepatitis after transfusion with blood containing antibody to hepatitis b core antigen. | we tested the hypothesis that donor blood containing antibody to hepatitis b core antigen (anti-hbc) but lacking detectable hepatitis b surface antigen (hbsag) and antibody (anti-hbs)might transmit type b hepatitis by examining donor and recipient serums from a veterans administration study of post-transfusion hepatitis. donor blood was available from three patients with type b hepatitis and from one patient with hepatitis b virus infection (development of anti-hbs and anti-hbc) without symptoma ... | 1978 | 652005 |
| transfusions and hepatitis: update in 1978. | 1978 | 652008 | |
| [humoral immunological studies in viral hepatitis and in hbag virus carriers]. | 1978 | 652352 | |
| prevalence of hepatitis b virus infection and hepatocellular carcinoma in chinese-americans. | 1978 | 659925 |