Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| papain solubilization of the epstein-barr virus-induced membrane antigen. | the epstein-barr virus (ebv)-induced membrane antigen (ma) was successfully solubilized from the membranes of viable ebv-infected raji cells by treatment with papain (5 to 6 u per 1 x 10(7) to 2 x 10(7) cells). the loss of ma from viable cells was monitored by membrane immunofluorescence and antibody-dependent cellular cytotoxicity. soluble ma was demonstrated in papain digests through inhibition of antibody-dependent cellular cytotoxicity and by inhibition of the binding of anti-ma antibodies t ... | 1978 | 81320 |
| epstein-barr antibodies in suspected nasopharyngeal carcinoma. | 1978 | 82106 | |
| epstein-barr virus d.n.a. in tumour tissue from native alaskan patients with nasopharyngeal carcinoma. | 1978 | 82107 | |
| longitudinal study of epstein-barr virus antibody titers and excretion in pediatric patients with hodgkin's disease. | nineteen pediatric patients with hodgkin's disease (hd) who had experienced primary epstein-barr virus (ebv) before, or in one case after, diagnosis, were studied longitudinally for changes in the titers and spectra of ebv-related antibodies, excretion of ebv into the oropharynx, the number of ebv-carrying lymphoid cells in the peripheral blood, and clinical signs and symptoms suggestive of reactivation of the latent virus. the incidence and geometric mean titers of igg antibodies to viral capsi ... | 1978 | 82539 |
| study of epstein-barr virus-determined nuclear antigen (ebna) by chromatography on fixed cell nuclei. | low ionic strength (50 to 100 mm nacl) and ph 6.0 were found to be optimal conditions for in vitro conversion of epstein-barr virus (ebv)-determined nuclear antigen (ebna)-negative nuclei to ebna-positive nuclei by addition of the complement-fixing (cf) antigen extracted from raji cells. in vitro conversion of nuclei to ebna-positively was sensitive to dnase but not to rnase treatment. this suggests that nuclear dna is a specific target substance to which ebv-cf antigen binds. if nuclei were fix ... | 1978 | 82540 |
| somatic cell hybrids between human lymphoma cell lines. v. idurd inducibility and p3hr-1 superinfectability of daudi/hela (dad) and daudi/p3hr-1 (dip-1) cell lines. | we have studied two types of somatic cell hybrid with regard to expression of the epstein-barr virus (ebv) cycle and its regulation. the first, dip-1, a hybrid formed between two human lymphoma ebv producers (daudi and p3hr-1), contained ebv dna, expressed the virus-determined nuclear antigen (ebna), andwas a producer of the ebv-associated antigens ea (early antigen) and vca (viral capsid antigen). the second, dad, a hybrid series of clones formed between daudi and a hela cell derivative (d98), ... | 1978 | 82545 |
| studies on epstein-barr virus-related antigens. iii. purification of the virus-determined nuclear antigen (ebna) from non-producer raji cells. | the purification of epstein-barr virus-determined nuclear antigen (ebna) was attempted on the basis of its biochemical and physicochemical properties and its immunological specificity, assayed by the indirect single radial immunodiffusion test and anti-complement immunofluorescence absorption test. when non-producer raji cell extract was subjected to 20--60% saturated ammonium sulfate fractionation, followed by dna-cellulose chromatography and immunoadsorbent chromatography, ebna was purified mo ... | 1978 | 82547 |
| selective stimulation and differentiation of early antigens in lymphoblastoid cell lines producing epstein-barr-like viruses. | comparisons of early antigens (ea) of ebv-related lymphotropic herpes virus of old world primates have proved difficult to accomplish because antigen levels are low in infected cells and the ratio of virus capsid antigen to ea is generally high. to overcome these difficulties, we have developed a procedure which combines antigen stimulation with inhibition of late virus functions and results in the selective stimulation of ea. using this procedure, we have examined the ea of ebv, herpesvirus pap ... | 1978 | 82609 |
| the association between undifferentiated nasopharyngeal carcinoma and epstein-barr virus shown by correlated nucleic acid hybridization and histopathological studies. | all of 51 undifferentiated carcinomas of the nasopharynx were ebv-dna-positive and, in the few tests performed, ebna-positive as well. most of these patients also had high anti-ebv [vca and ea (d)] antibody titres. of four patients that had somewhat differentiated npcs, two were ebv-dna-positive with a corresponding serological picture, whereas two were negative with an ebv serology comparable to that of healthy donors. of seven lymphomas localized in the nasopharynx, one was ebv-dna-positive an ... | 1978 | 83285 |
| biology and virology of the human malignant lymphomas: 1st milford d. schulz lecture. | permanent cell lines have been established from twelve diffuse histiocytic lymphomas (su-dhl-1 to -12), three american burkitt's lymphomas (su-amb-1 to -3), two acute lymphoblastic leukemias (su-all-1 and -2), and three diffuse undifferentiated lymphomas (su-dul-1, -2, and -3). the cultured cells displayed neoplastic characteristics, as manifested by heterotransplantability in congenitally athymic nude mice and by the presence of cytogenetic abnormalities in early passage generations. functional ... | 1979 | 83902 |
| characterization of a leukemic cell line of the pre-b phenotype. | 1979 | 83966 | |
| infection with e.b. virus and rheumatoid arthritis. | 1979 | 84110 | |
| the comparison between normal and epstein-barr virus-transformed homozygous typing cells and their use for mlc, plt and serological detection of human ia-type alloantigens. | normal human lymphocytes isolated from freshly drawn blood were repeatedly stimulated (up to five times) in mixed lymphocyte cultures (mlc) with five different epstein-barr virus (ebv)-transformed homozygous typing cells (htc-lcl). each time, the same wdw-specificity was used for the restimulation. the first and the second stimulations resulted in an 2.4- to 3.1-fold increase of the original responder cell number. but after the third, fourth and fifth stimulation decreasing amounts of specifical ... | 1979 | 84412 |
| transmission of non-a non-b hepatitis to chimpanzees by factor-ix concentrates after fatal complications in patients with chronic liver disease. | 6 cases of non-a non-b hepatitis which followed administration of four different batches of concentrates of coagulation factor ix from commercial and non-commercial sources are described. of 17 patients who received the concentrate on account of chronic liver disease, 4 developed hepatitis, and in 3 of these the illness proved fatal. the incubation periods ranged from 42 to 103 days (mean 65 days). 3 chimpanzees were inoculated with concentrate from the same batch used on the above patients, a f ... | 1979 | 85107 |
| intracranial heterotransplantation of human hematopoietic cells in nude mice. | a panel of established cell lines and many primary cell specimens from lymphomas and leukemias as well as from normal lymphatic tissues were tested for tumorigenicity by intracranial heterotransplantation in nude mice. not only lymphoma and leukemia cell lines, but also lymphoblastoid cell lines, lacking markers of malignancy, were tumorigenic in the brains of nude mice. these findings indicate that tumorigenicity following intracranial heterotransplantation in nude mice cannot be used as proof ... | 1979 | 38211 |
| epstein-barr virus infections in childhood. | igm and igg antibodies against epstein-barr virus (ebv) capsid antigen and antibodies against ebv nuclear antigen and heterophil antibodies were investigated in 115 paired sera of children with acute infections and in 100 sera of healthy controls of the same age and sex. ebv-specific igm antibodies could be recognized in 13.7% of the patients and in 7% of the controls. antibodies against ebv nuclear antigen were not detected in the igm-positive sera. | 1979 | 39436 |
| enhancement of epstein-barr virus antibody production in systemic lupus erythematosus patients. | two groups of 22 patients suffering from either systemic lupus erythematosus (sle) or infectious mononucleosis (im) were checked for epstein-barr virus capsid antigen antibody (eb-vca) production. the average significant antibody levels as well as the frequency of their occurrence were clearly higher in sle than in im patients. | 1979 | 39442 |
| some progress with nasopharyngeal carcinoma. | 1979 | 87621 | |
| evidence for antigenic distinctness of the epstein--barr virus-determined nuclear antigen and the herpesvirus papio-determined nuclear antigen. | previous serological evidence indicated that epstein--barr virus-determined nuclear antigen (ebna) has cross reactive components with the herpesvirus papio-determined nuclear antigen (hupna) and, in addition, it has distinct components of its own, not present in hupna. in the present study, this hypothesis was studied by absorption experiments. absorption of anti-ebna positive human sera with ebna abolished both anti-ebna and anti-hupna reactivity. absorption with hupna removed all anti-hupna re ... | 1979 | 88257 |
| abrogation of cell-mediated immunity by a serum blocking factor isolated from patients with infectious mononucleosis. | lymphocytes from 80% of patients with infectious mononucleosis in this study failed to produce macrophage migration-inhibition factor in response to partially purified early antigen of epstein-barr virus or to tetanus toxoid, whereas lymphocytes from normal subjects did produce this lymphokine. subsequent analysis of serum from the patients with infectious mononucleosis revealed a serum factor that completely abrogated antigen-specific inhibition of migration by human leukocytes as well as lymph ... | 1979 | 88489 |
| the antiherpesvirus action of phosphonoacetate. | 1979 | 88744 | |
| search for epstein-barr and type c oncornaviruses in systemic lupus erythematosus. | lymphoblastoid cell lines were derived from patients with active systemic lupus erythematosus by allowing spontaneous transformation of peripheral b lymphocytes (b cells) harboring endogenous epstein-barr virus or by superinfecting peripheral lymphocytes with exogeneous epstein-barr virus. results of extensive studies aimed at identifying type c oncornaviruses in these lymphoblastoid cells were entirely negative by electron microscopy, dna-dna hybridization, reverse transcriptase assays, and coc ... | 1979 | 88943 |
| epstein-barr virus-induced membrane antigens: immunochemical characterization of triton x-100 solubilized viral membrane antigens from ebv-superinfected raji cells. | in an attempt to qualitatively identify the membrane antigen (ma) complex induced by epstein-barr virus (ebv) infection of lymphoblastoid cells, superinfected raji cells were surface labelled with 125i by the lactoperoxidase method and solubilized with triton x-100, then the 125i-labelled membrane proteins were precipitated by sera containing high antibody titers to ma. analysis of these immune precipitates on sodium dodecyl sulfate polyacrylamide gel eletrophoresis identified four major ebv-spe ... | 1979 | 89099 |
| differential inducibility of epstein-barr virus in cloned, non-producer raji cells. | cells of the human lymphoblastoid non-producer line raji were cloned in soft agar. individual colonies were isolated and analyzed for their inducibility of the epstein-barr virus-associated early antigen (ea). the induction of ea by the tumor promoter tpa varied among the different cell clones. clones with very high and very low inducibility of the resident epstein-barr virus genome were further analyzed. constant differences in the inducibility of ea were observed after activation by tumor prom ... | 1979 | 89100 |
| perinatal infection by epstein-barr virus. | 1979 | 89313 | |
| thymidine sensitivity of cultured leukaemic lymphocytes. | cultured leukaemic lymphocytes from patients with t, null, or pre-b acute lymphoblastic leukaemia are shown to be highly sensitive to growth inhibition by thymidine. thymidine sensitivity was correlated with reduced activity of the catabolic enzyme thymidine phosphorylase and sustained elevation of the deoxythymidine triphosphate pool after exposure to thymidine. it is suggested that thymidine may have a role in the management of certain acute lymphoblastic leukaemias of lymphomas. | 1979 | 89451 |
| reciprocal 8;14 translocation in ebv-negative b-cell acute lymphocytic leukemia with burkitt-type cells. | a cytogenetic study, including prophase-prometaphase chromosome analysis, of a patient with ebv-genome-negative acute lymphocytic leukemia of b-cell type with burkitt-type cells is presented. all bone-marrow mitoses examined had a 14q+ marker chromosome which was identified as a reciprocal 8;14 translocation of exactly the same type as in burkitt's lymphoma. | 1979 | 90020 |
| increased tendency to spontaneous in-vitro lymphocyte transformation in clinically active multiple sclerosis. | lymphocytes from 8 of 10 patients with clinically active multiple sclerosis (ms) but from only 3 of 18 patients with quiescent ms and 4 of 20 healthy donors transformed spontaneously on in-vitro culture. the transformed cells from all donors had the characteristics of b lymphocytes (surface and intracytoplasmic immunoglobulin and complement receptors) and carried antigens of epstein-barr virus. it is suggested that these results are further evidence that immunoregulation in active ms is abnormal ... | 1979 | 90801 |
| site of epstein-barr virus replication in the oropharynx. | cells and cell-free material in saliva, parotid secretions, and throat washings from patients with acute infectious mononucleosis and patients undergoing tonsillectomy were assayed for the presence of infectious epstein-barr (ebv) virus. the agent was invariably present in cell-free form in saliva; neither infectious virus nor viral antigens were found in the cells. tonsillar lymphocytes from eight patients were also free of ebv. in 10 of 40 patients virus was recovered in secretions from paroti ... | 1979 | 91888 |
| establishment of a lymphoblastoid cell line and isolation of an epstein-barr-related virus of gorilla origin. | a b-lymphoid cell line was established from a normal gorilla. the cells contained epstein-barr virus-related antigens, and herpesvirus particles were demonstrated by electron microscopy. dna-dna reassociation kinétics revealed 30 to 40% hybridization to epstein-barr virus with 50 genomes per cell. examination of the viral nuclear antigen with gorilla sera showed this to be a unique isolate termed herpesvirus gorilla. h. gorilla transformed gibbon b-lymphocytes in vitro. | 1979 | 92573 |
| correlation between epstein-barr virus membrane antigen and three large cell surface glycoproteins. | a correlation between epstein-barr virus membrane antigen (ma) and three surface glycoproteins has been established on the basis of radio-immunoprecipitation and immunoabsorption experiments. for radio-immunoprecipitation, epstein-barr virus-infected cells were radiolabeled either with neuraminidase-galactose oxidase tritiated borohydride, a procedure highly specific for surface glycoproteins, or with a general tritiated amino acid mixture. intact cells were incubated with ma(-) or ma(+) human s ... | 1979 | 92577 |
| education of mouse lymphocytes against human lymphoblastoid cell lines: specific recognition of determinants independent of serologically defined hla allotypes and epstein-barr virus-coded antigens. | 1979 | 93053 | |
| [epstein-barr virus associated burkitt's lymphoma in a french child (author's transl)]. | pathologic diagnosis of malignant lymphoma, burkitt type, was made in a 12 year old child with an abdominal tumour. the association of this lymphoma with epstein-barr virus was done based on the detection of epstein-barr viral markers within the tumour cells, as well as on the patient's serology. to our knowledge, it is the first time that the association between burkitt's lymphoma and epstein-barr virus, which is frequent in africa, is reported in a caucasian french. | 1979 | 93275 |
| epstein-barr virus-specific antibody-dependent cellular cytotoxicity in patients with burkitt's lymphoma. | coded sera from 54 patients with african burkitt's lymphoma (bl) were titrated for antibodies against an epstein-barr virus (ebv)-induced membrane antigen in the antibody-dependent cellular cytotoxicity (adcc) assay. the titers were then correlated with the progression of lymphoma growth following chemotherapy. in 74% of the patients with high adcc titers (greater than 3,840), lymphomas showed partial or complete regression following therapy. in the medium-titered group (240-3,840), 36% of the l ... | 1979 | 93578 |
| abortive expression of the epstein-barr virus (ebv) cycle in a variety of ebv dna-containing cell lines, as reflected by nucleic acid hybridization in situ. | a variety of epstein-barr virus (ebv) dna-containing cell lines have been tested for the expression of the ebv-associated antigens ebna (nuclear antigen), ea (early antigen), and vca (viral capsid antigen), and for the presence of cells containing disproportionate amounts of ebv dna. the antigen tests utilized immunofluorescence and 125i-labelled antibodies combined with autoradiography. ebv-dna was detected by in situ hybridization with 3h-labelled ebv rna complementary to p3hr-1 ebv dna (p-ebv ... | 1979 | 93584 |
| establishment of specific antibody producing human lines by antigen preselection and epstein-barr virus (ebv)-transformation. | specific antibody producing human cell lines were established by preselecting antigen binding b-lymphocytes and subsequently transforming ("immortalizing") them with epstein-barr virus (ebv). nnp-binding b-cells were isolated from the blood of three donors with high anti-nnp titers. ebv-transformation led to polyclonal cell lines that had 15-18% nnp receptor positive cells. a similar fraction of the cells produced nnp-specific plaques in the cunningham-szenberg assay. unconcentrated culture medi ... | 1979 | 95800 |
| herpesvirus papio: state and properties of intracellular viral dna in baboon lymphoblastoid cell lines. | herpesvirus papio (hvp) is an indigenous b-lymphotropic virus of baboons (papio sp.) present in latent form in baboon lymphoblastoid cell lines. it shares cross-reacting viral capsid and early antigens with the epstein-barr virus (ebv), and hvp dna and ebv dna show partial sequence homology. ebv-specific complementary rna was employed here as a probe to investigate the physical state of the hvp dna component in baboon lymphoblastoid cells after fractionation of cellular dna by density gradient c ... | 1979 | 113352 |
| liver disease in patients undergoing hemodialysis and kidney transplantation. | liver dysfunction was observed in 33% of patients treated by hemodialysis and kidney transplantation. fifty-eight percent of these cases of hepatitis occurred in patients with past or present hbs antigenemia, and 77% of hbsag-positive patients showed evidence of ld. however, during the course of a program conducted from 1969 to 1976 and involving 267 patients, the decrease in the prevalence of hbs antigenemia observed during the last two years did not lead to any reduction in ld incidence. in a ... | 1979 | 115244 |
| phosphofructokinase in human blood cells. | the subunit composition of phosphofructokinase from normal and malignant blood cells has been investigated by means of immunologic, electrophoretic, and chromatographic methods. immunoprecipitation tests were performed with three specific antisera recognizing each of the basic subunits of human phosphofructokinase: muscle, m-type; liver, l-type; and fibroblast, f-type. mature polymorphonuclear cells contain mainly l-subunits, while lymphocytes and platelets contain hybrids formed of l and f subu ... | 1979 | 156568 |
| establishment and characterization of human b-lymphocytic lymphoma cell lines (balm-3, -4 and -5); intraclonal variation in the b-cell differentiation stage. | this study describes the establishment of three non-burkitt b-lymphoma cell lines (balm-3, balm-4 and balm-5) originating from the pleural effusion of a patient with a poorly differentiated diffuse lymphocytic lymphoma. the cells of balm-3, -4 and -5 exhibited a number of properties which distinguish them from the usual b-cell type lymphoblastoid cell lines. thus, they lacked the epstein-barr virus genome and had abnormal chromosome constitutions including a 14q+ marker. the presence of the iden ... | 1979 | 160894 |
| false-positive serology in infectious monoucleosis. | 1979 | 85957 | |
| x-linked immunocompetence and epstein-barr virus oncogenesis. | 1979 | 86133 | |
| cell-mediated immunity to epstein-barr virus in nasopharyngeal carcinoma. | 1979 | 86139 | |
| amplified direct immunofluorescence (amdi) for detection of epstein-barr virus nuclear antigen. | low antigen concentrations could be identified in human cells by sequential application of (a) fitc-labeled human antibodies at high dilution, (b) rabbit antiserum to the hapten fluorescein isothiocyanate (fitc), and (c) fitc-anti-rabbit globulin. the high specificity of direct immunofluorescence (a) was not affected by the amplifying steps (b) and (c). using this amdi technique epstein-barr (eb) virus nuclear antigen (ebna) could be specifically stained with human sera up to a dilution of 1 : 4 ... | 1979 | 86587 |
| adenovirus infection and heterophile antibody production. | 1979 | 86693 | |
| [epstein-barr virus (ebv) infection of epithelial cells from the nasopharynx--the use of autoradiography (author's transl)]. | 1979 | 231647 | |
| [significance of virus-specific antibodies to ebv-antigens in patients with nasopharyngeal carcinoma (author's transl)]. | sera collected from patients with nasopharyngeal carcinoma, patients with other head and neck neoplasms, patients with infectious mononucleosis (im), and healthy donors were titrated for antibodies (igm, igg, iga) against epstein-barr-virus (ebv) specific antigens (vca, ea, ebna) by indirect and by antikomplementary immunfluorescence. npc-patients develop significantly high anti-ebv titers of igg and iga. in contrast patients with neoplasms (mainly carcinomas) arising in sites of the head and ne ... | 1979 | 231716 |
| reactivity of paul-bunnell type heterophile antibody in sera from infectious mononucleosis patients with the surface of lymphoid cells carrying epstein-barr virus genomes. | the possible presence of paul-bunnell (pb) antigen on epstein-barr virus (ebv)-transformed lymphocytes were investigated. of 23 ebv genome-positive lymphoblastoid cell lines tested all but one absorbed pb type antibody from the serum of an infectious mononucleosis patient. the one ebv-negative b cell line tested did not absorb the heterophile antibody. pb antibody, purified by an immunoadsorbent procedure using beef cell antigen, reacted with the ebv producer p3hr-1 cell line in an indirect memb ... | 1979 | 231730 |
| hodgkin's disease and infectious mononucleosis. | sequential sero-positive infectious mononucleosis is described in 3 sibs, 2 of whom subsequently developed hodgkin's disease. eb virus antibodies were present in the serum of both cases. | 1979 | 231818 |
| a serological survey of st lucia. | a serological survey of a random sample of 541 of the population of st lucia was undertaken. the prevalence of antibodies to dengue, herpes virus, vz, rotavirus, rubella and syphilis is described and compared with other communities. | 1979 | 232090 |
| intracellular state of epstein-barr virus dna in producer cell lines. | the physical state of the epstein-barr virus (ebv) dna in three cell lines which spontaneously produce virus has been characterized. circular ebv dna molecules have been found in p3hr-i, b95-8 and m8i cells. the size of the intracellular m8i circular ebv dna molecules is comparable with the linear virus genome isolated from virus particles but the circular p3hr-i and b95-8 dna molecules are shorter than the virion dna . in addition to the circular form, some ebv dna with physical properties indi ... | 1979 | 232128 |
| identification of transcribed regions of epstein-barr virus dna in burkitt lymphoma-derived cells. | rna was extracted from the burkitt lymphoma-derived cell line raji and from burkitt lymphoma tumor biopsies, isotope labeled in vitro by iodination with 125i, and hybridized to electrophoretically separated restriction endonuclease fragments of epstein-barr virus dna on nitrocellulose membranes. the results indicated that only certain parts of the epstein-barr virus genome are represented as polyribosomal rna in raji cells, with a pronounced dominance of rna sequences complementary to a 2.0 x 10 ... | 1979 | 232190 |
| [determination of igm and igg antibodies against the epstein-barr virus capsid antigen using the indirect immunofluorescence method (author's transl)]. | 1979 | 232207 | |
| sero-epidemiologic study of the epstein--barr virus infectivity in a healthy cuban population. | the indirect immunofluorescence test was used to study the level of humoral antibodies against viral capsid antigen of the epstein--barr virus (vca-ebv), and early antigen (ea) in the sera of 322 healthy donors of the havana city province. the age of donors ranged from several months up to 95 years. the results obtained indicate that the healthy population of cuba is infected by ebv as well as in other countries, even though the spread and the course of infection have its specific characteristic ... | 1979 | 232252 |
| epstein barr virus (ebv) and complement (c3) interactions with human lymphoid cells. | 1979 | 232455 | |
| enzyme immunoassay for detection of antibody to epstein-barr virus-specific early antigen. | antibody to epstein-barr virus-induced early antigen could be measured in sera using enzyme-linked antibody. the sensitivity of this assay was comparable to that of the indirect immunofluorescent technique. measurement of early antigen was accomplished on a producer cell line which was specifically treated to block late gene expression. it is now possible to measure epstein-barr virus-induced early antigen and viral capsid antigen antibodies by using the same cell line. | 1979 | 232507 |
| infection and persistence of varicella-zoster virus in lymphoblastoid raji cell line. | infection of raji cells by varicella-zoster virus (vzv) resulted in permissive infection with establishment of a persistently infected lymphoblastoid cell line. vzv antigens of the membrane and nuclear type, as detected by the indirect immunofluorescence membrane antigen (ifama) and anticomplement immunofluorescence (acif) tests, were observed. minute amounts of infectious virus were detected by co-cultivation of vzv-infected raji cells (raji-vzv), with permissive human embryo fibroblasts (hef). ... | 1979 | 232537 |
| [angioimmunoblastic lymphadenopathy: ultrastructural study of lymph nodes. possible relationship with epstein-barr virus (ebv) (author's transl)]. | angioimmunoblastic lymphadenopathy (ail) has been clinically and histopathologically described by several authors since 1972, but only a few papers have analyzed the morphological aspects of the lymph nodes as observed by using electron microscopy. in the past three years, we happened to see in the curie institute two typical cases of ail, both of whose clinical and immunological data are briefly reported in this paper. we describe some peculiar patterns observed on the lymph nodes during the ac ... | 1979 | 232552 |
| mitogen-induced differentiation of human cll lymphocytes to antibody-secreting cells. | peripheral blood lymphocytes from nine patients with chronic lymphatic leukaemia (cll) have been stimulated by photohaemagglutinin, pokeweed mitogen and epstein-barr virus. our results provide proof that the leukaemic b cells in cll are capable of responding to mitogenic signals by producing and secreting antibodies, transforming into blast cells, and, probably, increasing their rate of dna synthesis. | 1979 | 232570 |
| differentiation capacity and other properties of the leukemic cells of chronic lymphocytic leukemia. | 1979 | 232686 | |
| dna glycosylases of human lymphoblastoid cells. | lymphoblastoid cell lines were established after transformation by epstein-barr virus of peripheral lymphocytes from xeroderma pigmentosum (xp) patients and normal donors. these lines expressed b-lymphocyte characteristics. typical characteristics related to xp of these cell lines were not altered by transformation. extracts of these cells catalyzed release of uracil (ura) and 3-methyladenine (3meade) from ura-containing dna (ura-dna) and methylated dna (me-dna), respectively. these two activiti ... | 1979 | 232757 |
| [network-theories and humoral immune response in infectious diseases (author's transl)]. | 1979 | 232825 | |
| cell-mediated immune responses in man to epstein-barr (eb) virus infection. | 1979 | 232867 | |
| the epidemiology of burkitt's lymphoma: evidence for a causal association with epstein-barr virus. | 1979 | 232877 | |
| the possible role of epstein-barr virus in rheumatoid arthritis. | the sera of patients with rheumatoid arthritis form a precipitate with an antigen present in the sonicate of a human b (bone marrow-derived) lymphoid cell line (wil2). the antibody is distinct from rheumatoid factor. the antigen can be demonstrated by an immunofluorescence technique to be distributed within the nucleus of the wil2 cell and shows a discrete speckled pattern of nuclear staining. the nuclear antigen is not detectable in organ extracts from many animal species or in human t (thymus- ... | 1979 | 233172 |
| [application of immunoenzymic method and immunoautoradiographic method for the mass survey of nasopharyngeal carcinoma (author's transl)]. | 1979 | 233230 | |
| [detection of eb virus-specific iga antibody from patients with nasopharyngeal carcinoma by immunoenzymic method (author's transl)]. | 1979 | 233233 | |
| translocation 8;14 in an ataxia telangiectasia-derived cell line. | 1979 | 233260 | |
| phosphonoacetic acid: inhibition of transformation of human cord blood lymphocytes by epstein-barr virus. | phosphonoacetic acid disodium salt (paa) inhibited the transformation of human cord blood lymphocytes by epstein-barr virus (ebv) at concentrations of 50-100 microgram/ml. at these concentrations, paa had no effect on the multiplication of ebv transformed human lymphoblastoid cells or on the survival of human cord blood lymphocytes. the transformation of human cord blood lymphocytes by the b95-8 strain of ebv was measured by 3h-thymidine uptake, 5 days or more after infection. the degree of inhi ... | 1979 | 233303 |
| [detection of iga antibody to eb virus vca from patients with nasopharyngeal carcinoma by immunofluorescence test (author's transl)]. | 1979 | 233359 | |
| [study of giant group a marker chromosome in several burkitt lymphoma and lymphoblastoid cell lines with epstein-barr virus from different origins (author's transl)]. | 1979 | 233360 | |
| [serological mass survey of nasopharyngeal carcinoma (author's transl)]. | 1979 | 233641 | |
| epstein-barr virus specific iga serum antibodies in nasopharyngeal and other respiratory carcinomas. | in order to better understand the relationship between iga and igg antibodies to epstein-barr virus (ebv) in nasopharyngeal carcinoma (npc), we analyzed 230 npc sera but also a series of sera from patients with other carcinomas selected for their high ebv/igg antibody titres. we were surprised to find that 21 out of 46 sera from bronchopulmonary carcinomas (bpc) and 6 out of 7 carcinomas of nasal fossae were iga anti-vca positive, and 9 bpc sera and 5 nasal fossae sera were also positive for iga ... | 1979 | 231014 |
| antibody-dependent cell-mediated cytotoxicity against epstein-barr virus membrane antigen in african burkitt's lymphoma. | serial samples of sera from patients with african burkitt's lymphoma were tested for antibody against epstein-barr virus (ebv)-specific membrane antigen (ma) by the antibody-dependent cell-mediated cytotoxicity assay (adcc). titers of patients in the long-term survivor group were generally higher than those found in the sera of patients in the short-term survivor group. although adcc titers to ebv-ma were not useful in predicting which patients would relapse there was a definite relationship bet ... | 1979 | 231015 |
| blocking of acid-fixed nuclear binding of epstein-barr virus nuclear antigen (ebna) by different dna species. | treatment of epstein-barr virus-determined nuclear antigen (ebna) with dna resulted in blocking of its ability to convert acid-fixed ebna-negative cell nuclei to an ebna-positive form. epstein-barr virus (ebv) dna, herpes simplex virus type 2 (hsv-2) dna and dna isolated from three lymphoblastoid cell lines differed in their potency to block this reaction. ebv dna was found to be about three times more effective than cellular dnas in abolishing the ability of dna-cellulose-purified ebna to conve ... | 1979 | 231093 |
| psychosocial risk factors in the developmental of infectious mononucleosis. | in a 4-year prospective seroepidemiological study of infectious mononucleosis (im) of one class of some 1400 cadets at the west point military academy, susceptibles and immunes were identified by the absence or presence of antibody to epstein-barr virus (ebv), the causative agent, and new infections by the appearance of antibody (seroconversion). on entry, about 1/3 lacked ebv antibody, of whom some 20% became infected (seroconverted); about 1/4 of seroconverters developed definite, clinical and ... | 1979 | 231279 |
| [the molecular biology of herpes viruses: (part ii) dna structure analysis and latent viral genomes of ebv, mdv, h. saimiri, cmv etc. (author's transl)]. | 1979 | 231281 | |
| infectious mononucleosis and agranulocytosis. | infectious mononucleosis is often complicated by haematological abnormalities but agranulocytosis is so rare that a causal relationship has been questioned. we here describe 2 sisters, 3 and 5 years old, who both developed agranulocytosis or profound granulocytopenia 4-5 weeks after the acute onset of mononucleosis. no contributory cause could be found and we conclude that a constitutional disposition may be responsible for this complication. | 1979 | 231301 |
| prevalence of antibodies to soluble antigen of epstein-barr virus-producing cells (p3hr-1) in the sera of hamadryas baboons of the high lymphoma incidence stock. | soluble antigen of p3hr-1 cells (sa-p3hr-1) was identified in indirect double immunodiffusion enhanced with tannic acid using serum of a nasopharyngeal carcinoma patient containing high-titer antibodies to epstein-barr virus (ebv) antigens. sa-p3hr-1 was nonidentical to soluble antigen of raji cells. human and baboon sera containing antibodies to all the known antigen of ebv and hvp respectively were anti-sa-3hr-1-positive. human and baboon sera containing antibodies to all the known antigens of ... | 1979 | 231520 |
| infectious mononucleosis. | an up-to-date review of the clinical diagnostic and treatment of infectious mononucleosis, emphasizing on new etiological concepts (epstein-barr virus) and pathogenetic (t and b lymphocytes) interaction is presented. | 1979 | 224362 |
| infectious mononucleosis and encephalitis: recovery of eb virus from spinal fluid. | 1979 | 224373 | |
| diagnostic aspects of the cytomegalovirus mononucleosis syndrome in previously healthy persons. | the mononucleosis-like syndrome due to cytomegalovirus (cmv) has many clinical features in common with classic epstein-barr virus (ebv) induced infectious mononucleosis (im). the hematologic and hepatic findings in both diseases are identical. diagnosis of the cmv-im syndrome usually can be made on the basis of indirect immunofluorescence for cmv macroglobulins (cmv-igm). ebv virologic tests may also be necessary, as patients with primary ebv infections may have cross-reactions at low titer in t ... | 1979 | 224385 |
| viral etiology of diseases of the hematopoietic system. | 1979 | 224431 | |
| a new approach to the study of human b lymphocyte function using an indirect plaque assay and a direct b cell activator. | 1979 | 224538 | |
| [burkitt's lymphoma. review and 4 danish cases]. | 1979 | 224544 | |
| analysis of early and late epstein-barr virus associated polypeptides by immunoprecipitation. | 1979 | 224588 | |
| enhancement of epstein-barr virus replication in producer cell lines by a combination of low temperature and corticosteroids. | 1979 | 224594 | |
| polypeptides of the epstein-barr virus membrane antigen complex. | epstein-barr virus (ebv)-associated membrane antigens have been purified from the plasma membranes of the producer cell line p3hr-1 nono. the antigens were assayed with a specific rabbit anti-ebv antiserum using an 125i-labeled staphylococcal protein a binding assay. the antigens have been shown to be present on purified plasma membranes. treatment of the plasma membranes with triton x-100 allows the separation of two antigenically distinct classes of antigens, one soluble and one insoluble in t ... | 1979 | 228070 |
| [dynamics of peripheral white blood cell pattern in infectious mononucleosis]. | 1979 | 228501 | |
| [role of the epstein-barr virus in human pathology]. | 1979 | 228518 | |
| [epstein-barr virus and neoplasms]. | 1979 | 228519 | |
| persistent falsely positive rapid tests for infectious mononucleosis. report of five cases with four--six-year follow-up data. | in many laboratories, rapid slide tests incorporating differential absorption have replaced heterophil antibody tube tests in the investigation of suspect infectious mononucleosis. the present report describes serologic data from five individuals whose monospot tests remained falsely positive for four years or more without other evidence of infectious mononucleosis or underlying disease states. three of the five had never been infected with the epstein-barr virus. all five had negative results w ... | 1979 | 228546 |
| heterogeneity of epstein-barr virus. | 1979 | 228725 | |
| epstein-barr virus: structure of the viral dna and analysis of viral rna in infected cells. | 1979 | 228726 | |
| the relation between epstein-barr virus antibodies and clinical symptomatology and immunodeficiency in patients with hodgkin's disease. | anti-epstein-barr virus (ebv) titers were measured in the sera of 37 patients with hodgkin's disease and in 40 normal controls. the patients were grouped according to histologic type, clinical symptomatology (relapse or remission), and their immune state (immunodeficient or non-immunodeficient). anti-epstein-barr nuclear antigens (ebna) and antiviral capside antigens (vca) titers were higher in patients with hodgkin's disease than in the controls. anti-ebna titers were significantly higher in pa ... | 1979 | 228834 |
| [on the problem of relationship between toxoplasmosis and eb virus infection (author's transl)]. | 1979 | 228853 | |
| increased sensitivity of new methods for detection of ebv antibodies and implications for infectious mononucleosis. | 1979 | 228889 | |
| epstein--barr virus-associated antibodies in igg and iga of nasopharyngeal carcinoma patients. | 1979 | 228890 | |
| the rescue of epstein--barr virus from primary cultured cells of nasopharyngeal carcinoma. | 1979 | 228891 | |
| dynamics of epstein--barr virus antibody titre in nasopharyngeal carcinoma. | 1979 | 228893 |