Publications

hypoxanthine transport in normal and malaria-infected erythrocytes.		1981	7024014
[think of malaria!].	a drug addict, treated because of a lung abscess, was found to have plasmodium vivax malaria and was treated accordingly. the second patient acquired falciparum malaria inspite of chloroquine prophylaxis and was admitted with a thrombocytopenia of 24 000 mm3. after chloroquine treatment the platelet count became normal. thrombocytopenia is usually present in falciparum malaria. complications and their treatment are discussed.	1981	7024070
inhibition of in vitro growth of plasmodium falciparum by immune serum from monkeys.	three owl monkeys that had been immunized against the camp strain of plasmodium falciparum by infection were treated with chloroquine and rechallenged with parasites. immune serum caused a dose-dependent, time-dependent inhibition of in vitro parasite growth. heat-inactivation eliminated nonspecific inhibition by normal monkey serum without diminishing immune inhibition. purified igg from immune serum inhibited parasite growth. serum taken immediately before the second challenge did not inhibit ...	1981	7024432
plasmodium falciparum resistant to fansidar.		1981	7024758
[use of chemotherapeutic preparations in regions with a spread of chloroquine-resistant tropical malaria].		1981	7024770
[hemostatic system disorders in malaria (a review of the literature)].		1981	7024773
[search for new antimalarial compounds (a review of patents)].		1981	7024774
concurrent inhibition by tunicamycin of glycosylation and parasitemia in malarial parasites (plasmodium falciparum) cultured in human erythrocytes.	tunicamycin (0.1--10 microgram/ml) incubated 96 h with human erythrocytes infected with malarial parasites significantly decreased parasitemia compared to controls. the antimalarial effect of tunicamycin was dose-related and paralleled its inhibition of the incorporation of radiolabeled glucosamine into parasite-derived membrane macromolecules. tunicamycin had no significant effect on isoleucine incorporation into parasite-derived macromolecules. these results suggest that tunicamycin may act by ...	1981	7025026
2-deoxyglucose: inhibition of parasitemia and of glucosamine incorporation into glycosylated macromolecules, in malarial parasites (plasmodium falciparum).	cultured malarial parasites were incubated with various doses of 2-deoxyglucose (0.5, 1.0, 5.0, and 10.0 mm) for 48 h. effects of 2-deoxyglucose on parasite survival were determined by counting the number of parasites/10,000 erythrocytes. effects of 2-deoxyglucose on synthesis of membrane proteins and glycosylated macromolecules were monitored by metabolic labelling using radioactive isoleucine and glucosamine, respectively. 2-deoxyglucose significantly reduced parasite survival and synthesis of ...	1981	7025027
[treatment of malaria (p. falciparum) with clindamycin].		1981	7025170
syndrome of inappropriate antidiuretic hormone (siadh) in measles and malaria infections.	sodium concentrations and osmolalities of simultaneously obtained venous blood and urine have been determined in a total of 61 children consisting of 18 children with malaria infection, 18 children with measles infection and 25 age- and sex-matched controls. the mean plasma osmolalities in the malaria and measles groups were significantly lower than in the control group (p less than 0.01). there was no difference between the measles and malaria groups either in their plasma osmolality (p greater ...	1981	7025395
chemotherapy of malaria.	the chemotherapy of malaria is incomplete without taking into consideration the widespread presence of chloroquine resistant falciparum malaria necessitating the use of a combination of antimalarials in order to effect a radical cure. fortunately, there has been no evidence of chloroquine resistance thus far with p vivax and p malariae. chloroquine resistant falciparum strains are present in about 85% of patients suffering from falciparum malaria but fortunately over 90 percent of the resistant ...	1981	7025744
[drug resistance to malaria. apropos of 17 cases in 2 years].	17 cases of resistant p. falciparum malaria are reported. they were observed in different populations: on one hand 9 cambodian children refugees in france, on the other hand 8 french adults consulting after travels in south america or in south-east asia. different resistance levels to amino-4-quinolines and to a combination of sulfadoxine and pyrimethamine were found: they were more often from the ri type but sometimes from the riii type also. 6 patients were treated with mefloquine. its activit ...	1981	7026070
falciparum malaria among military recruits: emphasis on early diagnosis and treatment.		1981	7026230
cerebral malaria: a diagnostic dilemma. a case report.		1981	7026363
continuous in vitro cultivation of plasmodium falciparum: replacement of human serum by calf serum and proteose peptone.		1981	7026430
parasite-derived mitogenic activity for human t cells in plasmodium falciparum continuous cultures.	supernatants from plasmodium falciparum continuous cultures exhibited mitogenic activity against human blood lymphocytes from unsensitized donors. this effect, which was not observed with supernatants from control cultures grown in the absence of the parasites, was dependent upon (i) the concentration of supernatant added to the lymphocyte cultures and (ii) the parasite concentration in the p. falciparum continuous cultures. t cells were the predominant target cells of this mitogenic activity. w ...	1981	7026445
inhibitory effects of erythrocyte membrane proteins on the in vitro invasion of the human malarial parasite (plasmodium falciparum) into its host cell.	the intracellular development of the erythrocytic stage of the malarial parasite (merozoite) is initiated by the attachment of the parasite to the erythrocyte surface. this paper describes an assay system to investigate plasmodium falciparum merozoite entry into the host cell and reports on three observations regarding this interaction. (a) merozoites do not invade human erythrocytes treated with either trypsin or neuraminidase, and both enzymes partially cleave glycophorin a, the major erythroc ...	1981	7026577
in vitro studies of malarial parasites using resealed ghosts of human erythrocytes.	a method has been determined for the preparation of resealed erythrocyte ghosts that are suitable for in vitro studies of plasmodium falciparum. the resealed ghosts have been characterized with respect to their shape, size, stability in culture and their hemoglobin and atp contents. light and electron microscopy has revealed that parasites are able to develop normally in resealed ghosts. even resealed ghosts containing very reduced levels of the normal erythrocyte cytoplasmic constituents are ca ...	1981	7027270
purine metabolism during continuous erythrocyte culture of human malaria parasites (p. falciparum).	through use of techniques for continuous erythrocyte culture and novel chromatographic procedures we have identified the major salvage pathways for metabolism of purine bases in p. falciparum infected human erythrocytes. the malaria parasitized erythrocyte (prbc) differs from the unparasitized mature erythrocyte (rbc) in the following ways: prbc primarily utilize hypoxanthine for synthesis of both adenylates and guanylates; prbc incorporate the base guanine into guanylates at a higher rate than ...	1981	7027271
seroepidemiology of malaria: age-specific pattern of plasmodium falciparum antibody, parasite and spleen rates among children in an endemic area in peninsular malaysia.	a seroepidemiological study was carried out on orang asli (aborigines) children who lead a semi-nomadic life in the deep jungles of ulu kelantan, malaysia. out of a total of about 190 children below 14 years, 143 were studied. blood was collected from finger pricks on standard "strip type" filter papers for indirect fluorescent antibody (ifa) tests with plasmodium falciparum antigen. a positive reaction at 1:10 dilution in infants and young children was considered positive and the reasons are gi ...	1981	7027557
treatment of tropical diseases (malaria and amoebiasis).		1981	7027706
immunoadsorbent isolation of antigens from the culture medium of in vitro cultivated plasmodium falciparum.	immunoadsorbent technique was used for isolation of soluble antigens from the culture medium of in vitro grown p. falciparum. two antigens were isolated and shown to be immunochemically identical to 2 antigens present in plasma from west africans with p. falciparum parasitaemia. evidence is provided that 1 of the antigens is an amphiphilic antigen of the s-class.	1981	7027738
[fluorescent antibodies in children in acute p. falciparum malaria in an endemic area].		1981	7027981
[2 breton cases of autochthonous malaria, in reality the first french cases of "airport malaria"].	two cases of plasmodium falciparum malaria encountered in finistere in 1969 are regularly referred to in the literature as infections acquired in brittany. in view of the extreme rarity of such an occurrence, it was decided to reexamine the data and consider in detail the biological and epidemiological factors for and against the possibility of infection occurring in brittany.	1981	7028295
[polyresistance of asiatic p. falciparum to chloroquine and pyrimethamine-sulfadoxine combination. apropos of a new case].	the authors report a case of a multi-drug resistant asiatic p. falciparum strain in a first non-immune man treated out of an endemic zone after failure of chemoprophylaxis by pyrimethamine-sulfadoxine. the authors compare this care with the lately published cases in germany and switzerland. they call again that i and ii resistances were observed at the time of the drug's trials in and out of endemic zones. they ascertain that this resistances are often associated with chloroquino-resistance and ...	1981	7028296
detection of glucose-6-phosphate dehydrogenase in malarial parasites.	the ability to carry out the initial reaction of the pentose phosphate pathway was investigated with extracts of mouse erythrocytes infected with plasmodium chabaudi, purified merozoites of p. knowlesi, and schizonts of p. falciparum grown in vitro in human erythrocytes. glucose-6-phosphate dehydrogenase activity (g-6pd) was detected in extracts of all the cells after electrophoresis on polyacrylamide gels. separate host cell and parasite glucose-6-phosphate dehydrogenase activities were demonst ...	1981	7012616
analysis of protein variation in plasmodium falciparum by two-dimensional gel electrophoresis.	the proteins of cultured isolates of plasmodium falciparum have been labelled with [35s]methionine and then examined for variation between isolates by the two dimensional gel electrophoresis system of o'farrell. a large number (ca. 100) of proteins have been characterised in terms of their isoelectric point and molecular weight, and thirty five proteins have been compared in all isolates. these comparisons have been used to examine two main questions, namely whether there is any evidence for sub ...	1981	7012617
[a 2d patient with tropical malaria contracted in a natural way in the netherlands].		1981	7012644
cryoglobulins, circulating immune complexes, and complement activation in cerebral malaria.	a total of 32 patients with plasmodium falciparum malaria were studied. of these, 23 had benign infections, and 9 had typical cerebral malaria. cryoglobulins, circulating immune complexes detected by a c1q-binding assay, and hypocomplementemia were found in eight of nine patients with cerebral malaria. raised levels of complement component 3 breakdown products (c3d) were found in the seven patients tested. peak levels of circulating immune complexes and c3d were associated with thrombocytopenia. ...	1981	7012010
complement does not facilitate plasmodial infections.	the influence of the complement (c) system on plasmodial infections in vivo (plasmodium berghei in rats) and in vitro (plasmodium falciparum) has been determined. in rats c3 depletion by treatment of animals with the c3 inactivator isolated from cobra venom factor results in infection that develops more rapidly, reaches a higher peak of parasitemia and is associated with an increased mortality rate (60%), in contrast to a lower degree of parasitemia and lack of mortality in c3-intact rats. the i ...	1981	7012239
[transfusional malaria in france (1960-1979) (author's transl)].	transfusional malaria is not a rare condition in france: in the past 20 years, 110 cases were cited in the literature and/or reported to us in answers to a recent questionnaire. of these, 24 cases occurred between 1960 and 1969 and 78 between 1970 and 1979. this apparent increase in occurrence in the past decade is most probably due to the increase in the number of transfusions of whole blood or fresh fractions containing infected erythrocytes, although population exchanges with inter-tropical a ...	1981	7010306
immunological aspects of nephrotic syndrome in northern nigeria.	immunological aspects of 40 northern nigerian children with nephrotic syndrome of recent onset are reported. eight our of 30 had hepatitis-associated antigen in their sera. hypocomplementaemia was rare. measurement of serum c3, c4, and asot was not of diagnostic value. proteinuria selectivity index was poor in half of the patients, and appeared t o depend on the severity of the kidney lesion. abnormal immunofluorescence of kidney glomeruli to immunoglobulins, complement, plasmodium malariae, and ...	1981	7011214
malaria-induced thrombocytopenia.	platelet counts were investigated in 26 patients with p. falciparum malaria and 39 patients with p. vivax malaria before and after treatment. before schizontocidal treatment 22 of 26 (85%) patients with p. falciparum malaria and 30 of 39 (72%) patients with p. vivax malaria had depressed platelet counts below 150,000/microliters blood. there was a correlation between low platelet counts and high counts of malarial plasmodia (parasitized red blood cells) in p. falciparum and p. vivax infections ( ...	1981	7011445
correlation of plasmodium falciparum gametocytemia with complement component titers in rural nigerian school children.	the relationship between plasmodium falciparum gametocytemia and the complement components c3, c4, and c3b was investigated in 141 ambulant rural nigerian school children. three groups were studied. group 1 included 42 children with circulating p. falciparum gametocytemia in which the mean titers of c3, c4, and c3b were 145.4 +/- 22.6 mg/100 ml (72%), 60.5 +/- 0.2 mg/100 ml (149%), and 64.0 +/- 5.9 mg/liter (65%), respectively. these findings indicated marked c3b hypocomplementemia. group 2 incl ...	1981	7007423
inhibitory effects of immune monkey serum on synchronized plasmodium falciparum cultures.	we studied the effects of heat-inactivated immune monkey serum on the growth of a partially synchronized culture of plasmodium falciparum. by light microscopy, parasites within erythrocytes were morphologically indistinguishable from those cultured in normal serum. immune serum reduced by 90% the number of erythrocytes containing newly invaded rings. clusters of extracellular merozoites, usually around clumps of malarial pigment, were seen frequently in cultures grown with immune serum but rarel ...	1981	7011066
adaptation of a nigerian strain of plasmodium falciparum to panamanian aotus trivirgatus.	a patent infection (more than 190 days duration) with plasmodium falciparum, obtained directly from a patient who had been exposed to malaria in nigeria, was established in a splenectomized panamanian owl monkey, aotus trivirgatus griseimembra. subinoculations from the original monkey recipient into one splenectomized and two normal a. t. griseimembra produced primary patient parasitemias of 18-54 days duration. these results represent the first successful adaptation of p. falciparum from man to ...	1981	7011068
courses of infections with plasmodium falciparum in own monkeys displaying a microfilaremia.	infections with the uganda palo alto, malayan camp-ch/q, vietnam oak knoll, and vietnam smith strains of plasmodium falciparum in owl monkeys (aotus trivirgatus griseimembra) with concomitant microfilaremias usually, but not always, followed a more benign course than infections with the same strains in monkeys free of filarial infections. four distinct microfilariae were identified in systematic examinations of 26 monkeys, 5 with self-limited infections with p. falciparum, 9 with normally benign ...	1981	7011072
field incubator for measuring drug susceptibility of plasmodium falciparum.	the battery-operated incubator described in this report is portable, inexpensive, and reliable. combined with a simple candle-jar desiccator, it can be used for the cultivation of p. falciparum under field conditions. this should promote the use of the in vitro microtechnique for assessing drug susceptibility of malaria parasites, particularly in areas where a conventional source of electricity is not available.	1981	7009884
[malaria tropica].		1981	7010059
use of a synthetic adjuvant in an effective vaccination of monkeys against malaria.		1981	7005690
a note on chloroquine sensitivity in p. falciparum in sonepat district (haryana).		1981	6757318
possible transmission of malaria by renal transplantation.		1981	6783170
non-a, non-b hepatitis after experimental transmission of malaria by inoculation of blood.	in a 1969 prisoner volunteer study of malaria transmission by blood inoculation, six persons were subinoculated sequentially, and acute hepatitis occurred in the last four (sequential study). subsequently, another 15 volunteers receiving malaria-rich blood from 14 different donors were followed prospectively (prospective study), and hepatitis developed in six. incubation periods were shorter but serum transaminase levels were higher for the cases of hepatitis occurring in the sequential study th ...	1981	6783707
malaria diagnosis by enzyme-linked immunosorbent assays.	enzyme-linked immunosorbent assays (elisa) for detecting malarial parasites in blood were tested on uninfected monkeys and in monkeys infected with plasmodium falciparum. a double antibody sandwich elisa detected one malarial cell per 10(3) uninfected cells, and an inhibition elisa detected on infected cell per 10(4) uninfected erythrocytes. these methods are not yet as sensitive as conventional blood-film examinations, in which a well-trained microscopist might be expected to detect one malaria ...	1981	6786604
hydroxypiperaquine phosphate in treatment of falciparum malaria.		1981	6788464
hydroxypiperaquine phosphate in treating chloroquine resistant falciparum malaria.		1981	6788465
malaria prevention in travellers from the united kingdom. report of meetings convened by the ross institute.	malaria prophylaxis is relative, not absolute, but can provide much protection. travellers must take prophylactics regularly while in malarious areas and for one month thereafter; despite doing so, they may still develop malaria. for areas without chloroquine-resistant malaria, chloroquine, 300 mg base weekly, or proguanil, 100-200 mg daily, are preferred. in areas of chloroquine sensitivity there may be places with resistance to proguanil and pyrimethamine, but these places are not delineated. ...	1981	6789972
chloroquine-resistant plasmodium falciparum malaris acquired in east africa--pennsylvania.		1981	6793833
antimalarial activity of selected aromatic chelators. ii. substituted quinolines and quinoline-n-oxides.		1981	6793844
the six diseases of who. malaria.		1981	6797554
[transfusion-induced malaria: risks, prevention and cost (1 year's experience)].	three cases of transfusion induced paludism have been seen in rouen since 1976. two of them were due to plasmodium falciparum and the third to plasmodium malariae. in order to improve the prevention of this disease, a survey was carried out in 1980 which concerned 51,000 blood samples, 1,020 blood donors were selected because they had lived in a malarial endemic zone. among them, 92 subjects were detected by an indirect immunofluorescence reaction as having a titer exceeding 1: 20 and their bloo ...	1981	6800022
tropical infections contracted in papua new guinea and imported into western australia.	diseases contracted in papua new guinea (png) and observed in western australia (wa) have comprised malaria, amoebiasis, ancylostomiasis, filariasis and leprosy. this small series of cases demonstrates the prolongation of incubation periods of malaria following chemoprophylaxis, the spread of chloroquine-resistant strains of plasmodium falciparum (both to western and eastern regions of png), the ineffectiveness of chloroquine against entamoeba histolytica in the intestine and the value of oral p ...	1981	6950604
prospects for the development of malaria vaccines.	the collection of epidemiological data on malaria in man dates from the time of the discovery of the human-pathogenic plasmodia, and, in retrospect, many of these observations can be seen to have an immunological connotation. this circumstantial evidence of the immunological phenomena in malaria was obtained during the first quarter of this century through the analysis of parasitological, clinical, and epidemiological data. the second quarter brought confirmation of the existence of a variety of ...	1981	6976843
[malarial infections with plasmodium falciparum resistant to chloroquine treatment. the situation in brazil (1960-1981)].		1981	6758067
[treatment of malaria with a combination of 3 drugs on são luís island, maranhão, brazil].		1981	6758068
[resistance of plasmodium falciparum to antimalarials: practical implications and control prospects].	the author reviews the present knowledge on the resistance of p. falciciparum to various antimalarials, such as the inhibitors of the dehydrofolate reductase (proguanil, pyrimethamine, cycloguanil embonate and trimethoprim), the 4-aminoquinolines, quinine and the combination of sulfadoxine-pyrimethamine and combinations of other antimalarials and outlines the geographical distribution of p. falciparum chloroquine-resistant strains. the genetic peculiarities of resistance to antimalarials and the ...	1981	6760055
[malarial infections caused by plasmodium falciparum resistant to chloroquine treatment. the situation in brazil (1960-1981)].		1981	6760261
[treatment of malaria with a combination of 3 drugs on the island of são luis, maranhão, brazil].		1981	6760262
platelet hypersensitivity in acute malaria (plasmodium falciparum) infection in man.	during acute malaria infection, platelets in human platelet-rich plasma re hypersensitive to the addition of adp between 1.0 micro m and 5.0 micro m, or adrenaline 0.11 micro m as aggregating agents. the mean maximum aggregation amplitude (as % of light transmission) obtained from 8 subjects in response to added adp (1.0 micro m) , 39.8 +/- 27 (1sd), was significantly greater than the value in 6 controls (5.2 +/- 6.7 (1sd); t = 3,51 p less than 0.005). a similar pattern of response was obtained ...	1981	6458113
[ovale malaria imported into the rsfsr].		1981	6459523
falciparum malaria in north eastern sector.		1981	6754690
[immunodiagnostic findings in sera of patients with leishmaniasis, chagas' disease, malaria and amebiasis in endemic regions of venezuela (author's transl)].	66 serum samples from patients suffering from mucocutaneous leishmaniasis (20), chagas' disease (12), malaria (16) or amebiasis (18) were collected and examined with five different protozoic antigens (l. donovani, t. cruzi, p. fieldi, p. falciparum, e. histolytica) by means of the indirect fluorescent antibody test, the complement fixation test, the indirect hemagglutination test and the latex agglutination. cross-reactions were observed only between the sera from patients with leishmaniasis and ...	1981	6285563
fansidar-resistant falciparum malaria in papua new guinea.		1981	6109064
drug resistant strains of plasmodium falciparium in papua new guinea.		1981	6110015
the parasitic diseases of school children in lagos state, nigeria.	a survey of 5,595 primary school children in lagos state showed that most of the children were over-loaded with parasitic infestations which included malaria (37.7%), schistosomiasis (13.4%). ascariasis (74.2%), trichuriasis (75.8%), hookworm (29.5%) and tungiasis (49.5%). multiple infections were observed with about 16.2% harbouring all the causative organisms of the parasitic diseases enumerated above. the high prevalence of parasitic infestations among these children is an index of the commun ...	1981	6111920
monocyte erythrophagocytosis in falciparum malaria.		1981	6112321
resistance of plasmodium falciparum malaria to sulfadoxine-pyrimethamine ('fansidar') in a refugee camp in thailand.	since it was first introduced 'fansidar' (pyrimethamine 25 mg, sulfadoxine 500 mg) has been the preferred treatment for uncomplicated chloroquine-resistant plasmodium falciparum malaria in thailand. because many patients at a refugee camp in thailand did not seem to be responding to therapy 9 patients who received fansidar for p. falciparum infection were followed up with serial parasite counts. in all of them the infection was resistant to fansidar. the results of this study suggest that fansid ...	1981	6112445
separation of malaria-infected erythrocytes from whole blood: use of a selective high-gradient magnetic separation technique.		1981	6113443
malaria prophylaxis when visiting areas of east africa with chloroquine resistance.		1981	6114294
influence of systemic infections on xylose absorption.	serial blood-xylose concentrations have been determined in 28 papua new guineans after 25 g oral xylose; 9 had an acute and 8 a chronic systemic infection, 4 the tropical splenomegaly syndrome and 7 were free of infection. mean xylose was significantly depressed at 30, 60, 90 and 120 min in those with acute and chronic infections. correlations between xylose and serum albumin, alpha 1, alpha 2, beta- and gamma-globulin concentrations were not significant. when the xylose test is used in tropical ...	1981	6115556
anti-erythrocyte autoimmunisation during chronic falciparum malaria.	anaemia during malaria is not completely understood. fourteen cases of antierythrocyte autoimmunisation with anti-i specificity were investigated in a paris hospital during a period of 2 years. the patients lived in gabon and had not been taking antimalarial chemoprophylaxis. all had chronic malaria (strongly positive antimalarial immunofluorescent antibody tests). all the recognised caused for anti-erythrocyte autoimmunity were excluded. one possible explanation for these observations is some s ...	1981	6116046
malaria prophylaxis in areas of chloroquine resistance.		1981	6116880
malaria prophylaxis with chloroquine.		1981	6116940
anti-erythrocyte autoimmunization during chronic falciparum malaria.		1981	6117707
rat malarial glomerulonephritis. an experimental model of post-infectious glomerular injury.	this paper describes the immunopathologic findings in acute malaria-associated glomerulonephritis in the rat. young sprague-dawley rats were infected with plasmodium berghei berghei. the subsequent parasitemia and elevation of circulating clq-reactive immune complexes were transient while the appearance of anti-plasmodial antibody in the serum was persistent. sequential examination of renal tissue and urine revealed the following glomerular alterations: (a) granular, predominantly mesangial depo ...	1981	6117979
drug therapy for plasmodium falciparum malaria resistant to pyrimethamine-sulfadoxine (fansidar). a study of alternate regimens in eastern thailand, 1980.	a trial of drug regimens for treating plasmodium falciparum malaria was conducted in a refugee camp in eastern thailand where extensive 'fansidar' (pyrimethamine-sulfadoxine) resistance had been demonstrated. the efficacy of quinine alone was compared to that of quinine combined with either fansidar or tetracycline. quinine alone cleared the parasitaemia in 57 of 59 patients but failed to cure approximately one-third of these patients after 7 or 10 days of therapy. the addition of fansidar to qu ...	1981	6118522
quinidine in falciparum malaria.	fourteen patients with falciparum malaria were successfully treated with oral quinidine. twelve of these patients were followed for 35 days without recrudescence. in six patients the infection had already recrudesced after antimalarial treatment, which in two cases had included a full course of quinine. quinidine caused no cardiotoxicity, although the electrocardiogram qtc interval was prolonged by more than 25% in four patients. in-vitro cultures from nine of these patients and a further seven ...	1981	6118523
drug-resistant malaria.		1981	6118530
chronic falciparum malaria and anti-i autoantibodies.		1981	6118552
cinchona alkaloids and malaria.		1981	6118739
malaria prophylaxis with chloroquine.		1981	6118740
[transfusional malaria. apropros of a case in limousin].	transfusional malaria is a disease in continual increase because of the greater number of international journeys and because of the insufficient prophylaxis at the present time. the authors report a new case which occurred in limoges due to plasmodium falciparum. the blood-donor was cambodgian and specific immunological tests were positive on this serum. any fever, without evident cause, happening after blood or blood-derivative transfusion must suggest transfusional malaria. this diagnosis must ...	1981	6119946
inhibition of p. falciparum growth in human erythrocytes by monoclonal antibodies.	malaria is increasing in incidence and prevalence in most tropical areas and is a major problem for both individuals and communities. current malaria research is aimed at developing vaccines and, for this, it may be useful to define plasmodium antigen(s) related to the development of a protective immune response in the host. monoclonal antibodies have recently been shown to interfere with rodent malaria infection (plasmodium berghei) at the sporozoite or merozoite stage. we have now raised monoc ...	1981	6161311
plasmodium falciparum: assay of invasion of erythrocytes.		1981	6161838
monoclonal antibodies to stage-specific, species-specific, and cross-reactive antigens of the rodent malarial parasite, plasmodium yoelii.	eighteen hybridoma cell lines were used to study species-specific, stage-specific, and serological cross-reactive antigens of the rodent malarial parasite, plasmodium yoelii. specificity and location of plasmodial antigens were determined by indirect fluorescent-antibody analysis. results showed that a minimum of 12 distinct plasmodial antigens could be distinguished by the 18 hybridomas. antigens were found on the surface or within the cytoplasm of the parasite, but not on the surface of erythr ...	1981	6166558
positive correlation between degree of parasitemia, interferon titers, and natural killer cell activity in plasmodium falciparum-infected children.	natural killer (nk) cell activity and interferon levels have been measured in the peripheral blood of children acutely ill with plasmodium falciparum infection. the nk cell levels were found to be raised in the malaria-infected children, with a positive correlation between the degree of parasitemia and lytic activity. comparatively high titers of antiviral activity was discovered in sera from the majority of p. falciparum-infected children, again positively correlating with the degree of parasit ...	1981	6170696
plasmodium falciparum: in vitro induction of resistance to aminopterin.		1981	6172284
plasmodium falciparum: assay of antigens and antibodies by means of a solid phase radioimmunoassay with radioiodinated staphylococcal protein a.	human red blood cells (rbc) infected in vitro with plasmodium falciparum were employed to prepare several types of antigens (sonicated, infected rbc and purified, sonicated merozoites and schizonts). these antigens, as well as control preparations derived from non-infected rbc, were used to coat plastic tubes, which were subsequently tested for capacity to bind anti-p. falciparum antibodies. binding was detected by means of radio-iodinated staphylococcus protein a. sera from patients with recent ...	1981	6172891
[presence of circulating interferon in serum of patients with plasmodium falciparum].		1981	6174189
[imported malaria at the chu in rouen (author's transl)].	in the bacteriology-parasitology laboratory of chu in rouen, we diagnosed from 1970 to 1978: 49 cases of imported malaria and 3 cases following transfusion of blood by finding of erythrocytic parasite. it is necessary to report: 26 more cases, diagnosed by immunologic test (ifi) which, being the total number reported to 78. 71,5% of the cases of imported malaria were caused by plasmodium falciparum, including one fatal case of cerebral malaria. patients were europeans (45%) and immigrants living ...	1981	6261371
imidazole and polyene activity against chloroquine-resistant plasmodium falciparum.		1981	6270216
dihydroorotate dehydrogenase, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase in plasmodium falciparum.		1981	6277049
in vivo and in vitro sensitivity of falciparum malaria to quinine in thai children.	the study was carried out to assess the efficacy of quinine in children with falciparum malaria in relation to in vitro sensitivity (measured in terms of minimum inhibitory concentration: mic) and to trough serum levels of quinine during the course of treatment. fifty children aged ten months to 12 years with falciparum malaria were randomly divided into two groups. group i: 24 children were treated with quinine 10 mg base per body weight every eight hours for 14 days. group ii: 26 children were ...	1981	6185041
antigenic differences among isolates of plasmodium falciparum demonstrated by monoclonal antibodies.	hybridomas raised against two papua new guinea (png) isolates of plasmodium falciparum secreted monoclonal antibodies which bound to schizonts of all seven png isolates tested but not to schizonts of four non-png isolates from thailand, nigeria, ghana, and the netherlands. some of the monoclonal antibodies were tested for their ability to inhibit the growth of one png isolate, one thai isolate, and one nigerian isolate in vitro. only the growth of the png isolate was inhibited, thus demonstratin ...	1982	6185427
expression of strain-specific surface antigens on plasmodium falciparum-infected erythrocytes.	antigenic determinants present on the surface of squirrel monkey erythrocytes infected with late developmental stages of p. falciparum were recognized through their ability to bind antibodies present in the serum of immune monkeys. two different assays were used to demonstrate the presence of these antigenic determinants on the cell surface: the fluorescent labelling of intact cells in suspensions and the binding to protein a-sepharose. such determinants appear to be strain-specific and have, fo ...	1982	6185907
protective antibodies against erythrocytic stages of plasmodium falciparum in experimental infection of the squirrel monkey, saimiri sciureus.	serum and ascitic fluid from squirrel monkeys (saimiri sciureus) inoculated with erythrocytic stages of plasmodium falciparum were collected at different periods of the infection. protection against p. falciparum was achieved by passive transfer of the sera or fluid recovered from animals after spontaneous or drug-induced cure. purified immunoglobulins from the ascitic fluid also conferred protection. in contrast, protective antibodies directed against erythrocytic stages of p. falciparum could ...	1982	6185908
the genome of plasmodium falciparum. i: dna base composition.	some structural properties of the dna of plasmodium falciparum were studied thoroughly using several techniques. its g+c content was found to be extremely low (17-19%), the lowest reported for a living organism. the dna seems to be composed only of the four major bases as no methylated bases were detected. this dna had a tm value of 62.5 degrees c and its denaturation profile showed no marked intramolecular heterogeneity.	1982	6278419
concentration of plasmodium falciparum-infected erythrocytes by density gradient centrifugation in percoll.		1982	6281409
inhibition of the in vitro growth of plasmodium falciparum by d vitamins and vitamin d-3 derivatives.	d vitamins are effective inhibitors of the in vitro intraerythrocytic growth of plasmodium falciparum. disappearance of the parasitemia was observed after 48 h contact between infected cells and 5 x 10(-6) m 1 alpha-hydroxycholecalciferol, 5 x 10(-5) m 25-hydroxycholecalciferol (25-oh-d-3), 1 alpha, 25-dihydroxycholecalciferol or 2.5 x 10(-4) vitamin d-2 and d-3. a 48 h pretreatment of healthy erythrocytes with 5 x 10(-5) m 25-oh-d-3 did not change their susceptibility to invasion by the parasit ...	1982	6283344