Publications

[a formalized patient history--a new form of medical documentation].	in a work, the characteristic of a new form of medical documentation--formalized case record (fcr), which permits to obtain the detailed information about the state of a patient at all the stages of treatment, is given. because of the more and more wide introduction of a computer into the clinical practice, fcr can be considered as a necessary form of medical documentation. the universal character of a fcr permits to use it at different in-patient departments of surgical profile.	1976	2366423
[clinical and paraclinical aspects in q fever].		1976	16296529
genetic markers for schizotaxia.	evidence is presented for the occurrence of a locus for schizotaxia on the short arm of chromosome 6. this derives from study of 63 informative members of seven pedigrees in which the proband and a parent (or a sib of parent) suffered with schizophrenia and other kin were either normal or fell within a spectrum of conditions related to schizophrenia. for linkage of hla and schizotaxia a lod score, 2.57, at recombination frequency 0.15 is reported, which gives p = 0.008. this is in contrast to da ...	1976	420900
[the role of native ticks (ixodidae) in the epidemiology of q fever in germany].		1976	786590
[q-fever meningoencephalitis. case report].		1976	934398
q fever in cyprus.		1976	951195
q fever in the republic of ireland.		1976	1017922
[q fever].		1976	801305
q fever endocarditis.		1976	20792429
q fever in iran.		1976	61379
radiological evaluation of anal fistulae: a prospective study of fistulograms.	a review of 33 fistulograms in a four-year study is presented. four types of communicating tracts have emerged: single (58%), branched (18%), fistulous abscess (15%) and compound (9%). this classification has formed the basis of selection of operative treatment in all the cases. diminished lumbo-sacral angle was also found in most of the anal fistula cases and this establishes a possible association between the pathology of anal fistula and the low back syndrome.	1977	421419
late revascularization of the lower limb following acute arterial occlusion.	thirty-four patients presenting with signs of grave ischaemia of the lower limb following acute arterial occlusion had revascularization procedures performed. fifteen of the incidents followed embolism or thrombosis and 19 were due to a traumatic cause. limb salvage was achieved in 67 per cent of the nontraumatic group and in 56 per cent of the traumatic group. severe complications such as crush syndrome and disseminated intravascular coagulation occurred but there were no deaths. no significant ...	1977	420984
nickel in food: the role of stainless-steel utensils.	nickel may be found in prepared foods (tinned foods) at markedly higher concentrations than the safe threshold laid down for hypersensitive patients. some foodstuffs cooked in stainless-steel utensils attack the metal and thus contain much more nickel than when enamel or aluminum saucepans are used. among the natural organic acids which may be responsible for dissolving stainless-steel, oxalic acid is the most active at equivalent concentrations.	1977	421457
abnormal renal uptake of indium-111 chloride.		1977	421409
"our" logo?		1977	2366683
q fever and animal abortion in cyprus.	seventy-eight british soldiers stationed in the eastern sovereign base area (esba) in cyprus contracted q fever in the period december 1974 to june 1975. pneumonia developed in 59% of cases. of 31 patients tested, 81% had biochemical evidence of hepatitis although only one became clinically jaundiced. three patients (4%) suffered pericarditis. treatment with tetracycline had no apparent effect on the course of the disease. investigation revealed an abortion epidemic involving 21 mixed flocks of ...	1977	558666
[studies of the etiology of infectious abortion in cows in ruse district].	a total of 28,159 blood serum samples have been examined for brucellosis, 87--for leptospirosis, 84--for toxoplasmosis, 554--for the presence of rickettsii and neoreckettsii, and 193--for total protein content, albumin, and protein fractions, taken from cows in the course of the years on 40 dairy farms in the district of rousse. bacteriologically were examined 349 aborted fetuses, 178 samples of estral secretion, 57 placentae, and 1002 samples of washings and seminal fluid from bulls for vibrios ...	1977	562030
role of brucella and coxiella burnetii infections in pyrexia of unknown origin.		1977	566726
vaccination of naturally infected ewes against q-fever.		1977	15446
analysis of antibody response and immunoglobulins in sera of rabbits and guinea pigs immunized with coxiella burnetii.	rabbit and guinea pig sera and their immunoglobulin fractions (igm and igg) were examined by complement-fixation (cf), microagglutination (ma), opsonization-phagocytosis (op) and serum protection (sp) tests at intervals after immunization with live phase i and phase ii coxiella burnetii suspensions. in general, ma antibodies, but also decreased, earlier than cf antibodies. the anamnestic immune response was higher with lower primary doses. both phase ii and phase i cf and ma antibodies as well a ...	1977	18924
search for correlates of resistance to virulent challenge in mice immunized with coxiella burnetii.	mice immunized with live phase i or phase ii coxiella burnetii, with killed phase i or phase ii organisms or with trichloroacetic acid (tcae) or phenol (pe) extracts were resistant to intraperitoneal infection with phase i c. burnetii irrespective of whether or not they displayed phase i antibody response at the time of virulent challenge. increased phagocytosis of purified phase i organisms by blood leukocytes or peritoneal exudate cells (pec) was noticed only in mice with phase i agglutinating ...	1977	22238
synthesis of ribonucleotides and their participation in ribonucleic acid synthesis by coxiella burnetii.	synthesis of ribonucleic acid (rna) by the deoxyribonucleic acid-dependent rna polymerase of coxiella burnetii required adenosine, uridine, guanosine, and cytidine 5'-triphosphates. cell-free preparations of this obligate intracellular procaryotic parasite had competence to phosphorylate ribonucleoside mono- and diphosphates in the presence of exogenous adenosine and guanosine 5'-triphosphates to the corresponding di- and triphosphates. c. burnetii contained about 2 nmol of adenosine 5'-triphosp ...	1977	200603
alterations of acetylcholine enzymes in neuroblastoma cells persistently infected with lymphocytic choriomeningitis virus.		1977	193868
the storage lipids in tangier disease. a physical chemical study.	the physical states and phase behavior of the lipids of the spleen, liver, and splenic artery from a 38-yr-old man with tangier disease were studied. many intracellular lipid droplets in the smectic liquid crystalline state were identified by polarizing microscopy in macrophages in both the spleen and liver, but not in the splenic artery. the droplets within individual cells melted sharply over a narrow temperature range, indicating a uniform lipid composition of the droplets of each cell. howev ...	1977	193870
enzymatic conversion of proteins to glycoproteins.	the enzymatic transfer of the oligosaccharide moiety from an oligosaccharide-lipid to denatured forms of three secretory proteins--ovalbumin, alpha-lactalbumin, and ribonuclease a--has been demonstrated utilizing a membrane fraction from hen oviduct. based on a survey of 10 proteins denatured by sulfitolysis, the presence of the tripeptide sequence -asn-x-thr-ser- (x represents a variable amino acid) appears to be necessary but not sufficient for the protein to serve as acceptor in vitro. the re ...	1977	264667
path analysis: application in an epidemiological study of echinococcosis in new zealand.	the method of path analysis is described in detail. application of this analyogical systems is demonstrated using data from an epidemiological study of echinococcosis in new zealand. the results identified the major causal pathways determining echinococcus granulosus prevalence in dogs, based on multiple regression analysis of a linear causal model constructed from prior biological and epidemiological knowledge. only ethnic and sheep husbandry variables had important direct effect on prevalence ...	1977	265339
nerve growth factor receptors on human melanoma cells in culture.	purified mouse nerve growth factor (ngf)radiolabeled with 125i was tested for its ability to bind to a variety of different cultured cells. ngf binds readily to human and hamster melanoma cells but does not bind to many other cell lines. the three cell lines with the highest number of ngf receptors were derived from metastatic melanomas. one of these lines, a875, was studied in detail and was shown to have approximately 7x10(5) ngf receptors per cell with an association constant of 1.0x10(9) lit ...	1977	265522
glucocorticoid activity of various progesterone analogs: correlation between specific binding in thymus and liver and biologic activity.	when tested in an in vitro assay system, progesterone and various analogs of this steroid were shown to compete with [3h] triamcinolone acetonide (ta) for specific glucocorticoid receptors in both rat liver and thymus. of these analogs, the following derivatives of progesterone were potent competitors of ta binding and, when injected into adrenalectomized rats, induced regression of the thymus and marked increases in hepatic tyrosine aminotransferase activity: 11 beta-hydroxyl, 6 alpha-methyl, 6 ...	1977	281184
[behavior of the q fever vector coxiella burnetii in birds. 2. experimental infection of pigeons].		1977	319989
[behavior of the q fever vector, coxiella burnetii, in birds. 1. natural infections in birds].		1977	319990
cell-mediated and humoral immune responses in mice. iv. difference of the functional cell population between helper activity and delayed-type hypersensitivity.	helper activity in the anti-hapten antibody response was studied in mice in reference to the induction of delayed-type hypersensitivity (dth) to the carrier protein. mice were immunized either by an i.v. injection of alum-precipitated bovine serum albumin (ap-bsa) plus bacterial endotoxin or by a s.c. injection of bsa in freund's complete adjuvant, the latter being effective in inducing dth. the helper activity was estimated by the antibody response to the challenge with dinitrophenylated bsa (d ...	1977	321345
the germicidal effect of the open air in different parts of the netherlands.	using the microthread technique the survival of escherichia coli mre 162 in open air was measured in different parts of the netherlands. the presence of bactericidal compounds (open air factor = oaf) could be demonstrated on several days and quantitated in relative units of oaf concentration. in the absence of ozone the oaf concentration was always low. in the presence of ozone the oaf concentration was dependent on wind direction. at the selected microthread exposure sites air from areas with h ...	1977	321676
appearance of cellular and humoral immunity in guinea pigs after infection with coxiella burnetii administered in small-particle aerosols.	the development of humoral and cell-mediated immune responses was studied in guinea pigs infected with coxiella burnetti administered in small-particle aerosols. direct macrophage migration inhibition was observed in cultured peritoneal exudate cells as early as 3 days after exposure. maximum inhibition of macrophages cultured with phase i or ii antigen occurred 14 to 21 days postexposure and persisted through 35 days. this inhibitory action was no longer detectable at 42 days. serum antibody to ...	1977	324911
the stability of nascent ribosomal ribonucleic acid in growing escherichia coli.		1977	332550
[the behavior of the q-fever agent, coxiella burnetii, in birds. 3. experimental infection of quail].	after simultaneous aerogenic and alimentary infection of quail by intra-nasal inoculation of a suspension of c. burnetii, the agent was reisolated 6 h after infection from lung and gut, from the 3rd day on from the spleen, at the 8th and 10th day from blood, and from the 8th day on from liver and kidney. c.burnetii was found in various organs up to 21 days after infection. in the majority of birds agglutinating antibodies could be demonstrated from the 18th day up to termination of the experimen ...	1977	334506
vaccination of dairy cattle against q fever (coxiella burneti): results of field trials.	a phase i formalin-inactivated q fever vaccine, using the nine mile strain of the organism, was tested for its ability to prevent dairy cows from shedding coxiella burnetti in their milk. more than 1,400 holstein-friesian dairy calves and heifers from 5 dairies were used in field trials lasting over a 3-year period. vaccination of 476 calves resulted in a geometric mean antibody titer of 1:123.3 compared with 1:2.4 for 486 nonvaccinated calves. the milk samples from 163 vaccinated calves were te ...	1977	842916
fat of coxiella burnetti in macrophages from immune guinea pigs.	the interaction between coxiella burnetii and peritoneal macrophages obtained from immune guinea pigs was studied by transmission electron microscopy. phagocytosis and subsequent fate of ingested phase i and ii rickettsiae were compared. phase i rickettsiae were more resistant to phagocytosis than were phase ii organisms. macrophages from phase i- and ii-immunized animals were equally capable of phagocytizing rickettsiae. phase i and ii rickettsiae previously treated with normal serum multiplied ...	1977	844906
[pathologo-anatomic and experimental study of the morphology of q-fever].	the article presents a survey of the literature containing reports on lesions of some human organs in q-fever and on a possible role of the pathogene--rickettsia burnetii in the development of these lesions. pathoanatomical findings were compared with those of the experimental investigations of the q-rickettsial infectious process. the literature data and the author's own investigations confirm the capability of rickettsia burnetii of parasitizing in cells of the reticulo-endothelial system. thi ...	1977	856124
lesions in guinea pigs infected with coxiella burnetii strain m-44.	guinea pigs inoculated with the live m-44 vaccine strain of coxiella burnetii were examined grossly and microscopically for the presence of q fever-related lesions. mild myocarditis was observed in 38% of the infected animals but in none of the control animals. livers showed significant incidence of hepatitis, necrosis, and granuloma formation, especially during the first eight days of the infection. a much lower incidence of splenitis was also found but was considered to be of borderline signif ...	1977	864292
q fever in colombia, s.a. a serological survey of human and bovine populations.		1977	878731
observation on chemotherapy in cows chronically infected with coxiella burnetii (q fever).	pregnant dairy cows chronically infected with coxiella burnetii were treated orally with 8 mg of chlortetracycline per kilo of body weight each day for 30 days during their dry period. with the exception of a sample of mammary fluid collected at 28 days, rickettsiae were not recovered from the mammary fluids after the second week of treatment. in addition, the organism was not recovered by mouse inoculation from placental tissues, colostrum or calf tissues that were examined after parturition. r ...	1977	885444
[transovarial and transspermal transmission of coxiella burneti by the tick hyalomma asiaticum and its role in the ecology of q-rickettsiosis].	the transovarial transmission of c. burneti by the tick h. asiaticum was traced on three daughter generations during 751 days. the infection rate of the first generation ticks was found to be 5 times lower than that of the parental ones, of the second generations ticks--9 times lower while f3 population was characterized by 20 fold decrease in the infection rate. the transmission of c. burneti by the infected males of h. asiaticum to the females after copulation was observed in none of the 19 te ...	1977	909725
q-fever soluble vaccine effects in coxiella burneti sensitized humans.	a q-fever soluble vaccine (phase i c. burnetitrichloro-acetic acid extract) was administered in a single dose to 28 persons formerly immunized with the same soluble vaccine one year before and to other 28 persons which had naturally been infected with c. burneti one or two years ago. all these persons were skin-tested with the same but diluted vaccine 48 hrs before vaccination. mild local and general reactions were found only in the c. burneti previously infected vaccinees (local reactions in 9 ...	1977	910580
[occurrence of coxiella burneti in foodstuffs in animal origin].	some of the organs and secretions from q fever infected cattle originally intended for human consumption were tested for their coxiella content. in the cows, the udder and udder lymph nodes were found to contain over 75% of the exciters; the exciters were also found to a large extent in the milk, reaching levels of between 10(1) and 10(5) inf. e/ml milk. on the other hand, other parts of the animal used as meat were less infected. lymph nodes in the body contained 28%, liver, kidney, pancreas an ...	1977	911292
agglutinins to coxiella burnetii and brucella spp, with particular reference to brucella canis, in wild animals of southern texas.	the prevalence of agglutinins to coxiella burnetii and brucella spp, particularly brucella canis, was determined in 269 wild animals (14 species) in southern texas. serologic evidence of coxiellosis and brucellosis, including b canis infection, was shown for coyotes, raccoons, opossums, badgers, jackrabbits, and feral hogs. using the microagglutination test, the seroprevalence of c burnetii, phases i and ii (titer greater than or equal to 4) was 4.1 and 27.9%, respectively. for brucella agglutin ...	1977	924870
influenza virus-induced interferon production in mouse spleen cell culture: t cells as the main producer.		1977	302752
rickettsioses studies. 3. natural foci of rickettsioses in south bohemia.	antibodies against coxiella burnetii and against rickettsiae of the spotted fever group were found in human sera and in sera from domestic and wild animals collected in south bohemia. spotted fever group rickettsiae were also discovered in the tick ixodes ricinus. these results indicate the presence of both types of rickettsiae in this part of czechoslovakia. as no epizootics or epidemics of q fever have as yet been reported in the area, it can be assumed that c. burnetii occurs in the latent st ...	1977	304389
partial duplication 5q syndrome: phenotypic similarity in two sisters with identical karyotype (partial duplication 5q33 leads to 5qter and partial deficiency 8p23 leads to pter).	two sisters with statomotor developmental retardation microcephaly, hydrocephalus internus and externus without signs of pressure, heart defect (ventricular septal defect), early pulmonary resistance and characteristic facial changes were found to have the same unbalanced karyotype with partial trisomy 5q3300 leads to 5qter and partial monosomy 8p2300 leads to 8pter, derived from a balanced reciprocal paternal translocation: 46,xy,t(5;8)(q3300;p2300). the older girl was tested for the erythrocyt ...	1977	305758
[distribution of rickettsia burneti in poland. i. serological surveillance of domestic animals].		1977	580114
a seriological investigation of q fever in clinical patients.	results of a serological survey of 507 patients, 301 males and 206 females at the ahmadu bello university teaching hospital indicated a total 20.5 per cent, or 21.3 per cent in males and 19.4 per cent females, had been exposed to q fever agent and had circulating antibody against coxiella burnetii. most of the positive sera were from patients whose clinical diagnoses were typhoid and pyrexia of unknown origin though these generally are the commonest clinical diagnoses in the hospital. titres var ...	1977	592464
experimental q-fever infection in guineapig.		1977	611100
q fever antibodies in food animals of nigeria : a serological survey of cattle, sheep, and goats.		1977	615325
changes in some popliteal lymph node and spleen lysosomal enzymes following the infection or vaccination of guinea-pigs with coxiella burneti.		1977	615568
mesangio-capillary glomerulonephritis associated with q-fever endocarditis.	a patient with nephrotic syndrome and q-fever endocarditis (confirmed serologically and ultrastructurally) was found to have mesangio-capillary glomerulonephritis with parietal deposits of c3 and igm and some igm in the mesangium. elution studies showed that igm antibodies reactive against insoluble coxiella antigens were present in the kidney. review of the literature suggests that this type of immune complex nephritis may be associated with q-fever. possible reasons for the variability of the ...	1977	615847
activation of guinea pig macrophages by q fever rickettsiae.		1977	401688
differences in buoyant-density properties of coxiella burnetii and rickettsia rickettsii.	the pronounced change in the buoyant density of coxiella burnetii in cscl gradients that was caused by treatment with formalin or ultraviolet radiation was not observed with rickettsia rickettsii.	1977	403144
social organization and food resources availability in primates: a socio-bioenergetic analysis of diet and disease hypotheses.	data obtained during a field study of two species of nonhuman primates (alouatta villosa and ateles geoffroyi) living in the tikal national park in guatemala are used to suggest an answer to the question: to what extent is the existence of a particular form of social organization (group size, structure, and composition) an indication of the amount of energy in the form of food resources available to animals in a particular habitat? seven researchers working in teams spent 2,318 hours in the fiel ...	1977	403771
[rickettsial arteritis due to coxiella burnetii].	case of an 48 year old man who has presented from 1968 to 1973 a lot of diseases such as: --mitral incompletence discovered in 1968 in madagascar island in spite of many previous clinical examinations; --acute pneumonia and heart failure in january 1973. serological reactions of ricketsia were quite positive; --acute thrombosis of right humeral artery in may 1973. it has been treated by surgical way, bay "desobstruction" and by pass and medical treatment chloramphenicol). pathologic endartery ha ...	1977	403895
ultrastructural investigations on surface structures involved in coxiella burnetii phase variation.	by using the cytochemical staining procedure with concanavalin a, horseradish peroxidase, and diaminobenzidine, no surface carbohydrates with terminal alpha-glucosyl or sterically closely related residues could be detected on the cell walls of coxiella burnetii phases i and ii. using a polycationized ferritin derivative as a cytochemical probe, anionic binding sites were visualized in the electron microscope on cell membranes of c. burnetii phase ii, but not on phase i organisms. the sites appea ...	1977	404251
[seroepidemiological investigations on the prevalence of rickettsial antibodies in man in the federal republic of germany (author's transl)].	1,600 random serum samples from inhabitants of hesse were investigated for rickettsial antibodies by complement fixation test. antibodies were found in 19 samples (1,2%) against rmsf-group antigen with titers between 1:10 and 1:640. these results confirm recent reports on natural foci of such rickettsial infections in the federal republic of germany. antibodies against rickettsia of the typhus-group or coxiella burnetii could not be detected by the complement fixation reaction. none of the sera ...	1977	410727
transformation in bacillus subtilis: biological and physical evidence for a novel dna-intermediate in synchronously transforming cells.	competent b. subtilis cells exposed to transforming dna in the presence of edta bind, but do not take up dna. rapid and almost synchronous uptake of the bound dna is achieved by the addition of mg2+ ions in excess of the edta. at 30 degrees and at 17 degrees comparable numbers of transformants are produced from cells pre-loaded with dna at 30 degrees (after termination of uptake by the addition of dna ase the samples were incubated at 37 degrees). however, almost no transformants are produced wh ...	1977	414066
streptomycin-resistant, asporogenous mutant of bacillus subtilis.	a streptomycin-resistant mutantant of bacillus subtilis that is also asporogenous, was isolated and partially characterized. this strain, srb15, sporulated at a frequency of about 1% compared to the wild type frequency of greater than 70%. the two phenotypes were inseparable by transformation, suggesting that this strain carries a single mutation that causes it to be both streptomycin-resistant and spore-minus. the mutation cotransduces with cysa, the closest auxotrophic marker to the "ribosomal ...	1977	414073
[the appearance of q fever probably caused by the inhalation of milk aerosol in a pula dairy (author's transl)].		1977	579429
pleuropericardial lesion in q fever.		1977	861682
q fever endocarditis--a case occurring in the united states.		1977	851063
[radiograph and observation of the development of q-fever pneumonia (author's transl)].	the radiograph in q-fever pneumonia and the course of q-fever was reported with the help of 12 clinically examined cases. q-fever pneumonia is not to be diffrentiated from viral pneumonia or mycoplasmal pneumonia. a chronic course with residual infiltrates which lasts as long as two or three months is, however, more frequent in q-fever pneumonia. according to our observations, a correlation seems to exist between the severity of the clinical symptoms, the extent of the pulmonary infiltrate and t ...	1977	142052
pleuropericardial lesion in q fever.		1977	589332
[anthropozoonoses of the lungs (ornithosis, toxoplasmosis, q-fever) (author's transl)].		1977	594037
[analysis of serum immunoglobulins in a patient with chronic q-fever and endocarditis (author's transl)].		1977	843957
incidence of q fever in two inadequately investigated occupational groups.	in 1973 the authors investigated the incidence of q fever serologically by means of the reaction of complement fixation (rcf) and the method of immunofluorescent titration (mift) in two inadequately investigated occupational groups--communal workers from the town of russe and medical workers in obstetric departments of several towns in north bulgaria. in addition, they carried out comparative studies in order to characterize the incidence and the degree of affection from the same disease in othe ...	1977	346996
cell-mediated immune responses of guinea pigs to an inactivated phase i coxiella burnetii vaccine.	the ability of a killed phase i coxiella burnetii vaccine to induce cell-mediated immune responses in guinea pigs was studied. cell-mediated immune responses were assessed by the inhibition of macrophage migration and lymphocyte transformation assays. the macrophage migration response occurred rapidly and was detected at high levels, but was relatively short-lived. in contrast, the lymphocyte transformation response developed more slowly, and persisted for a longer period. the vaccine, given in ...	1978	624586
limits of rickettsial infectivity.	seven species of pathogenic rickettsiae were compared in five assay systems for group, species, strain, and phase differences in infectivity. the species examined include rickettsia prowazekii (breinl and cairo 3 strains), r. typhi, r. canada, r. rickettsii (sheila smith and r strains), r. conorii, r. sibirica, and coxiella burnetii in phases i and ii. pathogenicity was charcterized in terms of fever in guinea pigs. all comparisons of infectivity and pathogenicity were described in terms of numb ...	1978	624588
influence of etiology on the functional result of aortic valve replacement.	the functional result of aortic valve replacement has been assessed in patients treated for isolated aortic incompetence. using maximal oxygen uptake as an index of myocardial function, a significant difference (p less than .05) exists between the patients who had q fever endocarditis on the one hand and those who had bacterial endocarditis or rheumatic fever on the other hand. we believe that permanent myocardial damage occurs as a result of bacterial endocarditis and rheumatic fever but becaus ...	1978	636982
sero-epidemiology of q-fever in poultry.	the sero-epidemiology of q-fever was studied by capillary agglutination test at 25 poultry farms in the nainital and ajmer districts of uttar pradesh and rajasthan. of 589 birds tested, 78 (13.24%) had q-fever agglutinins (cat titers 1:8 to 1:64), involving 16 of the farms. there were more sero-reactors in ajmer (17.56%) than in nainital (3.35%). the sero-positive reactors were respectively 19.74% and 5.55% among the age groups above and below 6 months. the breed difference and comparatively hig ...	1978	646757
effects of infection with coxiella burnetii on synthesis of rna in l cells.	experimental infections with coxiella burnetii augment rates of ribonucleic acid (rna) synthesis in guinea pigs. the activity of deoxyribonucleic acid-dependent rna polymerase in l cells persistently infected with c. burnetii was threefold greater than that in unifected cells; the polymerase activity in infected cells was predominantly of class i, whereas that in uninfected cells was predominantly of class ii. a search for regulatory factors of polymerase activity revealed that preincubation of ...	1978	649991
evidence for the existence of q fever in northwest texas.		1978	655321
serum q fever antibodies in swedish un soldiers in cyprus--reflecting a domestic or foreign disease?	swedish soldiers from 2 battalions serving in cyprus 1975 and 1976 were tested serologically for coxiella burnetii phase 2 complement-fixing antibodies. 2.7% were positive. although none of the seropositive soldiers had been seriously ill abroad, the titers are considered to emanate from an infection in cyprus as there is no evidence of domestic q fever from a survey of 1390 swedes.	1978	675166
ultrastructural changes in guineapig liver experimentally infected with coxiella burnetii.		1978	680848
seroprevalence of q fever infection in human beings from southern region of kerala state.		1978	680877
sero-prevalence of q fever in nainital tarai.		1978	680894
metabolic sequelae of respiratory q fever in the guinea pig.		1978	693481
experimental infection of coxiella burnetii in chicken: clinical symptoms, serologic response, and transmission through egg.	young laying hens were infected with coxiella burnetii to study egg transmission, clinical and serologic responses, excretion of the agent in feces, and its persistence in internal organs. no clinical symptoms were noticed. the birds developed good titers in a capillary agglutination test by 13 days postinfection (dpi), which peaked at 30 dpi and therafter declined gradually, becoming negative in some birds around 90 dpi. in vivo and in vitro egg transmission of the agent could not be demonstrat ...	1978	697657
q fever antibodies in domestic animals in south kanara--a preliminary report.		1978	700847
prevalence of coxiella burnetii (q fever) and toxoplasma gondii among dairy goats in california.	the prevalence of antibodies against coxiella burnetii and toxoplasma gondii, the causative agents of q fever and toxoplasmosis, was examined in goats to determine the extent of the potential of goats to tansfer these infections to persons. of 1,054 goats from 234 premises in california, 248 goats (24%) were seropositive for c burnetii and 246 (23%) were seropositive for t gondii. of 29 dairy goats tested, 2 (7%) were found to be shedding the q fever rickettsia in their milk; t gondii was not de ...	1978	727592
experimental q fever infection in congenitally athymic nude mice.	congenitally athymic nude (nu/nu) mice and their phenotypically normal (nu/+) euthymic littermates were exposed to coxiella burnetii administered as small-particle aerosols. after challenge, both strains of mice became infected, as characterized by rickettsemia, viable rickettsiae in the spleen, and serological conversion. the major difference noted was that euthymic animals had cleared rickettsiae from peripheral circulation and the spleen within 14 days. in contrast, rickettsiae were detected ...	1978	730352
enhancement of the immunogenicity of phase i antigen of coxiella burnetii.	the immunogenicity of the soluble phase i antigen of coxiella burnetii for guinea pigs was enhanced by a nuclease-resistant complex of polyriboinosinic-polyribocytidylic acid, poly-l-lysine, and carboxymethyl cellulose.	1978	730378
[sensitivity of a rickettsia burneti strain to antibiotics].	tested were ten of the most frequently used broad-spectrum antibiotics. each preparation was used in concentrations of 0.001, 0.0005, 0.00025, and 0,00012 mg. the experiment made also use of the 35th passage in chick embryos of a rickettsial strain bp (titer 10--8) isolated from sheep. results showed that the test strain of r. burneti manifested a good sensitivity to tetracyclin and abricyclin, a moderate one to tetraolena, rondomycin, streptomycin, and chloramphenicol, and a strong one to ampic ...	1978	741640
mitogenic and protective activity associated with a lipopolysaccharide from coxiella burnetii.	a purified lipopolysaccharide (lps) isolated from the rickettsial agent of q fever, coxiella burnetii phase 1, possesses some of the in vivo and in vitro biological properties previously only associated with bacterial endotoxins. the coxiella lps is mitogenic for guinea pig leukocytes, induces non-specific resistance in mice to virulent candida albicans, causes dermal schwartzman reactions, and is positive by the limulus lysate assay.	1978	747820
abortion associated with coxiella burnetii infection in dairy goats.		1978	748297
sero-epidemiological evidence of coxiella burnetii infection among selected human population in calcutta.		1978	750441
experimental coxiella burnetii infection of guinea pigs and mice.	the susceptibility of five inbred strains of mice, designated dba/1j, dba/2j, c57bl/6j, balf/cj, and akr/j, as well as outbred hartley and moen-chase guinea pigs to infection with coxiella burnetii by several routes was studied. the dba/2j mice were more susceptible to infection and had higher mortality rates than other strains of mice. guinea pigs were more susceptible to infection than mice. lesions observed in the infected animals were similar to those previously described in man and experime ...	1978	750726
histopathological changes during experimental infection with coxiella burnetii in guinea-pigs (correlation with histochemical changes of rna).		1978	751596
use of a c. burnetii soluble antigen for skin test diagnosis in q fever.		1978	757660
cytotoxic activities of normal cultured human t cells.	normal human t cells grown in continued cultures in medium containing conditioned medium (cm) from pha-stimulated lymphocytes were studied for their ability to manifest three known forms of cell-mediated cytotoxicity: lectin-induced cellular cytotoxicity (licc), natural killer cell (nk) activity, and antibody-dependent cellular cytotoxicity (adcc). the cultured t cells (ctc) were very effective mediators of licc, being cytotoxic even at very low attacker-target cell ratios in the presence of dif ...	1978	308961
expression of human t lymphocyte antigens by killer cells.	k cells, the effectors of antibody-dependent cell-mediated cytotoxicity, were found to express human t but not b lymphocyte antigens detected by rabbit anti-htla and anti-hbla. pretreatment of effector cells with anti-htla+c inhibited adcc by specifically lysing k cells: no inhibition of adcc by anti-htla occurred when deltac was substituted for c. by contrast, pretreatment of effector cells with anti-hbla nonspecifically inhibited adcc, probably for forming antigen-antibody complexes with hbla+ ...	1978	308964
apparatus for uniaxial testing of soft human tissues in vitro.		1978	309051
method of production of and antibody response to an oil adjuvant bacteroides nodosus bacterin.	a procedure is described for the production of a highly concentrated bacteroides nodosus bacterin. an oil adjuvant bacterin which elicited the best antibody response in rabbits produced a response in sheep which lasted for at least 6 months.	1978	375151
cardiogenic hypertension.		1978	348044
plasmodium berghei infection in pregnant rats: effects on antibody response and course of infection in offspring.	the effects of primary, patent plasmodium berghei infection in sprague-dawley rats during pregnancy upon the course of infection and the humoral antibody response to malaria in their offspring were examined. malaria specific antibody determined by an indirect fluorescent antibody test correlated well with the parasitologic profiles of each experimental group. utilization of foster mother groups indicated passive transfer of protective antibody through milk. evidence for in utero sensitization by ...	1978	351159
[toxoplasma gondii. infection and its prevention].		1978	351357