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[fleas and diseases transmissible to man].fleas are wingless insects that parasitize mammals and more rarely birds. they are able to jump and may bite people. adult fleas are hematophagous. the impact of fleas on public health is related to their ability to act as vectors for transmission of infectious agents during blood meals. the purpose of this article is to describe fleas and the diseases that they transmit to humans. special focus is placed on epidemiological aspects.200616615611
bartonella henselae pap31, an extracellular matrix adhesin, binds the fibronectin repeat iii13 module.bartonella henselae wound-associated infections suggest involvement of extracellular matrix molecules in adhesion and invasion. pap31 was previously identified as a hemin-binding protein. our recent studies suggest the protein is an adhesin that is recognized by the host's immune systems. in this study we examined the interactions of b. henselae pap31 with fibronectin (fn), heparin (hep), and human umbilical vein endothelial cells (huvecs). the cloned gene was expressed in escherichia coli, and ...200616622186
cat-scratch disease in veterinary-associated populations and in its cat reservoir in taiwan.in taiwan, the first human case of cat-scratch disease (csd) was diagnosed by a serologic test in 1998. since then, no studies have been conducted to understand the epidemiology of the infection in taiwan. therefore, this study is the first epidemiologic survey of csd in cats and humans in this country. using veterinary-associated individuals as the study population, it was identified that 1.7% of them were seropositive for b. henselae, and residence was the only factor associated with seroposit ...200616641017
images in clinical medicine. cat scratch disease lymphadenopathy. 200616641391
parotid mass due to cat scratch disease.cat scratch disease (csd), due to bartonella henselae, is a self-limited chronic lymphadenopathy. a previously healthy 22-year-old woman presented with a palpable painful swelling in the right submandibular region accompanied by enlarged cervical lymph nodes. a diagnosis of b. henselae infection was made according to her personal history that divulged frequent contacts with cats and to a high titre of immunoglobulin g (igg) and igm antibodies for this agent. the patient improved within 1 month w ...200616669837
systemic granulomatous disease and sialometaplasia in a dog with bartonella infection.systemic granulomatous disease involving the spleen, heart, lymph nodes, omentum, liver, kidney, lung, mediastinum, and salivary glands developed in an 8-year-old rottweiler. the dog also had sialometaplasia of both submandibular salivary glands. bartonella henselae and b. vinsonii subsp. berkhoffii dna was amplified from the salivary gland by polymerase chain reaction analysis. bartonellae may be the cause of this systemic disease, but to the authors' knowledge, involvement of omentum, mediasti ...200616672593
model structure of the prototypical non-fimbrial adhesin yada of yersinia enterocolitica.non-fimbrial adhesins, such as yersinia yada, moraxella uspa1 and a2, haemophilus hia and hsf, or bartonella bada represent an important class of molecules by which pathogenic proteobacteria adhere to their hosts. they form trimeric surface structures with a head-stalk-anchor architecture. whereas head and stalk domains are diverse and appear (frequently repetitively) in different combinations, the anchor domains are homologous and display the properties of autotransporters. we have built a mole ...200616675268
secondary unilateral glaucoma and neuroretinitis: atypical manifestation of cat-scratch disease. 200616604397
experimental infection of human body lice with acinetobacter baumannii.the human body louse is currently recognized as a vector of rickettsia prowazekii, borrelia recurrentis, and bartonella quintana. previous studies have reported the isolation of acinetobacter baumannii from the body lice of homeless patients. to study how the body louse acquires a. baumannii, we infected a rabbit by infusing 2 x 10(6) colony-forming units of the louse strain of a. baumannii. two hundred body lice were infected by feeding on the bacteremic rabbit and compared with 200 uninfected ...200616606978
american association of feline practitioners 2006 panel report on diagnosis, treatment, and prevention of bartonella spp. infections. 200616846781
bartonella spp. in deer keds, lipoptena mazamae (diptera: hippoboscidae), from georgia and south carolina, usa.deer keds, lipoptena mazamae (diptera: hippoboscidae), were collected from white-tailed deer (odocoileus virginianus) and humans in georgia and south carolina, usa (1 october 2001-6 january 2005) and screened for the presence of dna from bartonella spp. forty deer keds were screened for bartonella spp. by polymerase chain reaction using primers specific to the riboflavin synthase gene (ribc) of bartonella. bartonella species closely related to bartonella schoenbuchensis and to the etiologic agen ...200616870863
first evidence of feline herpesvirus, calicivirus, parvovirus, and ehrlichia exposure in brazilian free-ranging felids.serum samples from 18 pumas (puma concolor), one ocelot (leopardus pardalis), and two little spotted cats (leopardus tigrinus) collected from free-ranging animals in brazil between 1998 and 2004 were tested by indirect immunofluorescence (ifa) for antibodies to feline herpesvirus 1 (fhv 1), calicivirus (fcv), coronavirus (fcov), parvo-virus (fpv), ehrlichia canis, anaplasma pha-gocytophilum, and bartonella henselae. serum samples also were tested, by western blot and elisa, for feline leukemia v ...200616870878
[study on bartonella vinsonii berkhoffii isolated from blood of native dogs in china].to isolate and identify bartonella strains from native dogs in shandong province in china.200616875539
cloning, characterization, and expression of bartonella henselae p26.in order to identify immunoreactive bartonella henselae proteins, b. henselae antiserum from an experimentally infected cat was used to screen a b. henselae genomic dna expression library. one immunoreactive phage clone contained a gene (p26) with significant nucleotide identity with orthologs in brucellae, bartonellae, and several plant-associated bacteria. p26 gene sequences from four b. henselae strains, one b. koehlerae strain, and one b. clarridgeiae strain were cloned. comparative nucleoti ...200616893981
broad-range polymerase chain reaction for the diagnosis of bartonella henselae endocarditis.we present a case of subacute bacterial endocarditis in a 10-year-old girl with di-george syndrome, congenital heart disease, and mild immunodeficiency. she was afebrile at initial presentation but was found to have massive splenomegaly, and signs of congestive heart failure. no causative organism could be identified on routine blood and tissue cultures. a detailed clinical history revealed a history that she had been scratched by a cat and developed intermittant fevers over 3 months. bartonella ...200616898887
description of pseudochrobactrum gen. nov., with the two species pseudochrobactrum asaccharolyticum sp. nov. and pseudochrobactrum saccharolyticum sp. nov.two gram-negative, rod-shaped, oxidase-positive, non-spore-forming, non-motile bacteria (ccug 46016(t) and ccug 33852(t)), isolated from a knee aspirate of a 66-year-old man and an industrial glue, respectively, were studied for their taxonomic position. on the basis of chemotaxonomic data [i.e. major ubiquinone (q-10), major polar lipids (phosphatidylethanolamine, phosphatidylglycerol and phosphatidylcholine) and major fatty acids (c(18 : 1)omega7c and c(19 : 0) cyclo omega8c)] and 16s rrna gen ...200616902015
ixodes frontalis and avian tick-related syndrome in the united kingdom.this study aimed to characterise tick species responsible for avian tick infestations in the uk, to analyse various risk factors for tick-related syndrome in tick-infested birds and to test samples for the presence of certain tick-transmitted pathogens.200616911113
in vitro susceptibility of bartonella species to 17 antimicrobial compounds: comparison of etest and agar dilution.in vitro susceptibility testing of 31 bartonella spp. strains including 21 bartonella henselae isolates was performed for 17 antimicrobial agents (telithromycin, four macrolides, five fluoroquinolones, five aminoglycosides, doxycycline and rifampicin).200616916864
serological and molecular evidence of exposure to arthropod-borne organisms in cats from northeastern spain.one hundred sixty-eight cat sera from spain were tested for igg antibodies to rickettsia conorii (rc), ehrlichia canis (ec), anaplasma phagocytophilum (ap) and bartonella henselae (bh) antigens using ifa and for felv antigen and fiv antibody by elisa. for 47 whole blood samples, pcr testing was performed for rickettsia, ehrlichia and bartonella. seroprevalences were: bh (71.4%), rc (44%), ec (11.3%), felv (8.5%), fiv (7.4%) and ap (1.8%). bh antibodies were associated with seroreactivity to both ...200616919405
[a case of cat scratch disease in a patient with diabetes mellitus and chronic renal failure].the article describes a case of cat scratch disease in a female patient with severe chronic pathology. this relatively rare disease was manifested by regional (in the site of microbial intrusion) lymphadenopathy, and general infectious syndrome. the presence of oncohematological process was excluded without biopsy; serologic examination with bartonella antibodies confirmed the diagnosis. combined treatment with two antibiotics, rifampicin and doxycycline, was successful. the article stresses tha ...200616924805
bartonella quintana variably expressed outer membrane proteins mediate vascular endothelial growth factor secretion but not host cell adherence.bartonella quintana causes trench fever, endocarditis, and the vasculoproliferative disorders bacillary angiomatosis and peliosis hepatis in humans. little is known about the interaction of this pathogen with host cells. we attempted to elucidate the interaction of b. quintana with human macrophages (thp-1) and epithelial cells (hela 229). remarkably, only b. quintana strain jk-31 induced secretion of vascular endothelial growth factor (vegf) from thp-1 and hela 229 cells upon infection similar ...200616926391
autocrine role for interleukin-8 in bartonella henselae-induced angiogenesis.the gram-negative bacterium bartonella henselae is capable of causing angiogenic lesions as a result of infection. previously, it has been shown that b. henselae infection can result in production of the chemokine interleukin-8 (il-8). in this study, we demonstrated that monocytes, endothelial cells, and hepatocytes produce il-8 in response to b. henselae infection. we also investigated the role of il-8 in b. henselae-induced endothelial cell proliferation and capillary tube formation. both in v ...200616926411
systemic cat scratch disease.systemic cat scratch disease (csd) is often associated with prolonged fever and microabscesses in the liver and/or spleen. we report a case of systemic csd with hepatic, splenic and renal involvement in an aboriginal child in taiwan. a previously healthy 9-year-old girl had an intermittent fever for about 17 days, and complained of abdominal pain, headache and weight loss. abdominal computed tomography showed multiple tiny hypodense nodular lesions in the spleen and both kidneys. laparotomy reve ...200616935770
genome rearrangements, deletions, and amplifications in the natural population of bartonella henselae.cats are the natural host for bartonella henselae, an opportunistic human pathogen and the agent of cat scratch disease. here, we have analyzed the natural variation in gene content and genome structure of 38 bartonella henselae strains isolated from cats and humans by comparative genome hybridizations to microarrays and probe hybridizations to pulsed-field gel electrophoresis (pfge) blots. the variation in gene content was modest and confined to the prophage and the genomic islands, whereas the ...200616936024
molecular characterization of resistance to macrolides in bartonella henselae.we selected in vitro erythromycin-resistant strains of bartonella henselae. the mutants obtained had point mutations in domain v of 23s rrna and/or in ribosomal protein l4. one lymph node of a patient with cat-scratch disease had such a mutation in 23s rrna, suggesting that natural resistant strains may infect humans.200616940128
case records of the massachusetts general hospital. case 27-2006. a 17-year-old boy with fever and lesions in the liver and spleen. 200616943407
analysis of data in 30 patients with cat scratch disease without lymphadenopathy.the prominent clinical manifestation of cat scratch disease is regional lymphadenopathy at the site of the cat scratch or bite, associated with fever or general symptoms. a serological study of 540 patients with either lymphadenopathy, persistent fever, or pet ownership disclosed that 30 (16.1%) of the 186 patients with a serological diagnosis of cat scratch disease had no regional lymphadenopathy, and in these 30 patients, the absence of lymphadenopathy was closely related to the presence of pe ...200616944264
prevalence of dna of mycoplasma haemofelis, 'candidatus mycoplasma haemominutum,' anaplasma phagocytophilum, and species of bartonella, neorickettsia, and ehrlichia in cats used as blood donors in the united states.to identify the prevalence of dna of mycoplasma haemofelis; 'candidatus mycoplasma haemominutum'; anaplasma phagocytophilum; and species of bartonella, neorickettsia, and ehrlichia in blood of cats used as blood donors in the united states.200616948578
prevalence of bartonella henselae antibodies in serum of cats with and without clinical signs of central nervous system disease.bartonella henselae is occasionally associated with neurological dysfunction in people and some experimentally infected cats. the purpose of this study was to determine whether b henselae seroprevalence or titer magnitude varies among cats with neurological disease, cats with non-neurological diseases, and healthy cats while controlling for age and flea exposure. there was no difference in b henselae seroprevalence rates between cats with seizures and cats with other neurological diseases. cats ...200616949848
[a case of hepatosplenic cat scratch disease].a 43-year-old man was admitted with idiopathic fever. abdominal ultrasonogram demonstrated multiple hypoechoic lesions in the spleen. abdominal ct scan showed multiple hypodense lesions in the liver and spleen. the patient had a cat in his house, and the presence of a very high serous antibody titer for bartonella henselae led to the diagnosis of hepatosplenic cat scratch disease. it is important to consider this disease in the differential diagnosis of idiopathic fever when multiple lesions are ...200616953102
alpha1-proteinase inhibitor deficiency and bartonella infection in association with panniculitis, polyarthritis, and meningitis in a dog. 200616955834
[hepatosplenic localization of cat scratch disease: two cases in immunocompetent adult patients].cat-scratch disease (csd) is a well-recognized benign cause of localized lymphadenopathy, which often recovers spontaneously. however systemic clinical presentations are described in immunodeficient adults (bacillary angiomatosis, bacillary splenitis) and are less common in immunocompetent ones.200616959382
bartonella quintana prosthetic valve endocarditis detected by blood culture incubation beyond 10 days.we describe the case of a 45-year-old man with mitral and aortic prosthetic valve replacement who presented with symptoms of subacute bacterial endocarditis. bartonella quintana was grown from blood after prolonged culture. the course of the disease was complicated by splenic infarction, glomerulonephritis resulting in progressive renal insufficiency, and cerebroventricular hemorrhage. notably, cardiac ultrasonography showed no extensive vegetations but a strand-like lesion. culture-positive b. ...200616962956
somatostatin receptor scintigraphy in patients with cat-scratch disease.somatostatin receptor scintigraphy images various neoplastic, granulomatous, and auto-immune diseases. cat-scratch disease in an infectious granulomatous disease usually affecting the lymphnodes. it is not known whether cat-scratch disease provides positive somatostatin receptor scintigrams.200616964341
[cat scratch disease--course, diagnosis].cat scratch disease is an infection which often causes regional lymphadenopathy. bartenolloses present a growing health problem both in human and veterinary medicine. they may be etiological fevers of unknown etiology, endocarditis, pneumonia, meningitis. the mildest clinical form is the cat scratch disease which proceeds as a mild regional lymphadenopathy. it is caused by bartonellosis henselae. animals, especially cats, are the sourse of infections. lymphadenitis may remain for many weeks and ...200616964683
rickettsial agents in egyptian ticks collected from domestic animals.to assess the presence of rickettsial pathogens in ticks from egypt, we collected ticks from domestic and peridomestic animals between june 2002 and july 2003. dna extracts from 1019 ticks were tested, using pcr and sequencing, for anaplasma spp., bartonella spp., coxiella burnetii, ehrlichia spp., and rickettsia spp. ticks included: 29 argas persicus, 10 hyalomma anatolicum anatolicum, 55 hyalomma anatolicum excavatum, 174 hyalomma dromedarii, 2 hyalomma impeltatum, 3 hyalomma marginatum rufipe ...200617004028
immunohistochemical study of lymph nodes in patients with cat scratch disease.bartonella henselaeis the causative agent of cat scratch disease (csd), manifesting as fever and acute regional lymphadenopathy. although serologic testing is the reference method for diagnosis, successful use of immunohistochemical (ihc) stain of regional lymph nodes for the diagnosis of csd has been reported. to determine the characterization and diagnostic potential of ihc in lymphadenopathy of csd, lymph nodes were excised from patients with suspected csd for further evaluation.200617098692
indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following listeria monocytogenes infection.control of pathogens by formation of abscesses and granulomas is a major strategy of the innate immune system, especially when effector mechanisms of adaptive immunity are insufficient. we show in human listeriosis that dcs expressing indoleamine 2,3-dioxygenase (ido), together with macrophages, are major cellular components of suppurative granulomas in vivo. induction of ido by dcs is a cell-autonomous response to listeria monocytogenes infection and was also observed in other granulomatous inf ...200617111046
bartonella henselae endocarditis in a child.14-year-old white male with a past medical history of congenital bicuspid aortic valve, streptococcus viridans endocarditis, and pulmonary valve homograft presented with culture-negative endocarditis. molecular studies identified the causative organism as bartonella henselae and subsequent serologic studies supported this diagnosis. this rare cause of endocarditis may be under recognized in children. bartonella henselae endocarditis should be considered in all children with culture-negative endo ...200617111290
infective endocarditis due to bartonella spp. and coxiella burnetii: experience at a cardiology hospital in sao paulo, brazil.bartonella spp. and coxiella burnetii are recognized as causative agents of blood culture-negative endocarditis (bcne) in humans and there are no studies of their occurrences in brazil. the purpose of this study is to investigate bartonella spp. and c. burnetii as a causative agent of culture-negative endocarditis patients at a cardiology hospital in são paulo, brazil. from january 2004 to december 2004 patients with a diagnosis of endocarditis at our institute were identified and recorded prosp ...200617114712
arthropod-borne diseases in homeless.homeless people are particularly exposed to ectoparasite. the living conditions and the crowded shelters provide ideal conditions for the spread of lice, fleas, ticks, and mites. body lice have long been recognized as human parasites and although typically prevalent in rural communities in upland areas of countries close to the equator, it is now increasingly encountered in developed countries especially in homeless people or inner city economically deprived population. fleas are widespread but ...200617114713
prevalence of rickettsia felis-like and bartonella spp. in ctenocephalides felis and ctenocephalides canis from la rioja (northern spain).our aim was to determine the presence of rickettsia spp. and bartonella spp. in ctenocephalides felis and ctenocephalides canis from la rioja (spain). a total of 88 specimens were tested by polymerase chain reaction (pcr) using glta and ompb genes as targets for rickettsia spp., and 16s rrna and ribc genes for bartonella spp. rickettsia felis-like (28.4%), bartonella clarridgeiae (6.8%), and bartonella henselae (3.4%) were detected in ctenocephalides spp. other bartonella sp. different from b. c ...200617114721
population survey of egyptian arthropods for rickettsial agents.between june 2002 and july 2003, 987 fleas, representing four species, and 1019 ticks, representing one argasid and eight ixodid species, were collected from egyptian animals. these arthropods were tested for rickettsial agents using polymerase chain reaction. dnas from anaplasma and ehrlichia spp. were detected in 13 ticks. previously undescribed bartonella spp. were detected in 21 fleas. coxiella burnetii was detected in two fleas and 20 ticks. rickettsia typhi was detected in 27 fleas from 10 ...200617114742
bartonella infection in domestic cats and wild felids.bartonella are vector-borne, fastidious gram-negative bacteria causing persistent bacteremia in their reservoir hosts. felids represent a major reservoir for several bartonella species. domestic cats are the main reservoir of b. henselae, the agent of cat-scratch disease. prevalence of infection is highest in warm and humid climates that are optimal for the survival of cat fleas, as fleas are essential for the transmission of the infection. flea feces are the likely infectious substrate. prevale ...200617114749
corpuscular antigenic microarray for the serodiagnosis of blood culture-negative endocarditis.blood culture-negative endocarditis is due to fastidious bacteria, including coxiella burnetii and bartonella spp. diagnosis of such infection relies on serology and microimmunofluorescence is therefore the reference method. we developed a multiplex serology test featuring automatic incubation and reading and incorporating internal controls. preliminary results indicate that this new serologic test is valuable for the rapid, automated serological diagnosis of blood culture-negative endocarditis.200617114786
a translocated bacterial protein protects vascular endothelial cells from apoptosis.the modulation of host cell apoptosis by bacterial pathogens is of critical importance for the outcome of the infection process. the capacity of bartonella henselae and b. quintana to cause vascular tumor formation in immunocompromised patients is linked to the inhibition of vascular endothelial cell (ec) apoptosis. here, we show that translocation of bepa, a type iv secretion (t4s) substrate, is necessary and sufficient to inhibit ec apoptosis. ectopic expression in ecs allowed mapping of the a ...200617121462
[endocarditis due to bartonella spp. three new clinical cases and spanish literature review]. 200617125688
[prevalence of bartonella henselae antibodies in chilean children, adolescents and veterinary workers].bartonella henselae is the causative agent of cat-scratch disease.200617130969
transient paresis associated with cat-scratch disease: case report and literature review of vertebral osteomyelitis caused by bartonella henselae.cat-scratch disease (csd) rarely presents as vertebral osteomyelitis. we describe a case with paresis of the arm with total recovery after antibiotic and neurosurgical therapy. we reviewed 20 other cases of csd vertebral osteomyelitis in the literature. this diagnosis should be considered in patients with systemic symptoms, back pain, and cat contact. the prognosis is generally good.200617133166
an unusual outcome in a child with hepatosplenic cat-scratch disease.typical cat-scratch disease (bartonella henselae infection) in an immunocompetent child is usually associated with a history of scratch, bite or intimate contact with a cat. most patients develop a non-tender papule in the scratch line after three to ten days. this may persist for only a few days or as long as two to three weeks. during the next two weeks or more, regional lymph nodes that drain the area gradually enlarge and then slowly resolve in more than 10% of patients. the nodes develop ov ...200617136337
[bacterial zoonoses: emerging concepts].bacterial zoonoses are evolving with changes in society, climate and lifestyles. a hierarchy of non food-borne zoonoses was recently proposed in france, and includes characteristics such as severity criteria and bioterrorism potential. the creation of specific networks and reference centers has provided the means to monitor the emergence (or re-emergence) of zoonoses such as brucellosis and q fever. molecular tools have facilitated the detection of bacteria that are transmitted by arthropod vect ...200617140097
molecular detection of rickettsia felis, rickettsia typhi and two genotypes closely related to bartonella elizabethae.a total of 56 fleas were collected from mice, rats, and one hedgehog in national parks of mainland portugal and the madeira island. all fleas were tested for the presence of bacteria of the genera rickettsia and bartonella using pcr assays. in fleas from mainland portugal, we detected rickettsia felis in one archaeopsylla erinacei maura flea and in one ctenophtalmus sp. in five leptopsylla segnis fleas taken from rats in the madeira island, we identified rickettsia typhi. in addition, in four fl ...200617038702
the reach of the genome signature in prokaryotes.with the increased availability of sequenced genomes there have been several initiatives to infer evolutionary relationships by whole genome characteristics. one of these studies suggested good congruence between genome synteny, shared gene content, 16s ribosomal dna identity, codon usage and the genome signature in prokaryotes. here we rigorously test the phylogenetic signal of the genome signature, which consists of the genome-specific relative frequencies of dinucleotides, on 334 sequenced pr ...200617040564
isolated hepatic involvement of cat scratch disease in immunocompetent adults: enhanced magnetic resonance imaging, pathological findings, and molecular analysis--two cases.visceral involvement in absence of lymphadenopathy is a rare manifestation in cat scratch disease; hepatic granulomas are rare, representing 0.3% of systemic manifestations of cat scratch disease, and gallbladder extension is a singular case. the present article refers to 2 rare cases of visceral cat scratch disease in immunocompetent adults with hepatic granulomatous inflammation, caused by bartonella henselae infection, with gallbladder involvement in 1 case and no lymphadenopathy. histologica ...200617041206
bartonella quintana, lice, and molecular tools. 200617017209
dynamics of the incw genetic backbone imply general trends in conjugative plasmid evolution.plasmids cannot be understood as mere tools for genetic exchange: they are themselves subject to the forces of evolution. their genomic and phylogenetic features have been less studied in this respect. focusing on the incw incompatibility group, which includes the smallest known conjugative plasmids, we attempt to unveil some common trends in plasmid evolution. the functional modules of incw genetic backbone are described, with emphasis on their architecture and relationships to other plasmid gr ...200617026718
lymph node biopsy specimens and diagnosis of cat-scratch disease.we report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (csd). the specimens were examined by standard, cell culture, and molecular methods. infectious agents were found in samples from 391 (49.7%) of 786 patients. the most commonly identified infectious agent was bartonella henselae (245 patients, 31.2%), the agent of csd. mycobacteriosis was diagnosed in 54 patients (6.9%) by culture and retrospectively confirmed by using a specific ...200617073081
[bartonella henselae as a cause of optical nerve neuritis].bartonella henselae is included into the group of gram-negative bacteria that can cause not so rare disease known as cat-scratch disease (csd). this disease is characterized by the specific general symptoms, and the complications in the eyes can be manifested in the form of neuroretinitis, follicular conjunctivitis and focal chorioretinitis. in this paper clinical and epidemiological characteristics of a patient with ophthalmologic complications caused by bartonella henselae are described. we in ...200617144434
[wild small mammals are the reservoir hosts of the bartonella genus bacteria in the south of moscow region].a total of 103 blood samples collected from wild small mammals captured in the prioksko-terrasny reserve on the south of moscow region were studied to determine the bartonellae prevalence. the examined species were the yellow-necked mice apodemus flavicollis (35 samples), the european wood mouse apodemus uralensis (10 samples), the bank vole clethrionomys glareolus (51 samples), the house mouse mus musculus (3 samples), the common vole microtus arvalis (2 samples), and the shrew sorex araneus (2 ...200617094651
[cat-scratch disease. review of eight adult patients hospitalized for fever or adenopathy].cat-scratch disease is common among children. among adults the disease is less often considered in the differential diagnosis of enlarged lymph nodes and fever.200617186093
[serous macular detachment as an atypical sign in cat scratch disease].case report: a 58-year-old woman presented with 0.1 visual acuity in the left eye associated with a serous retinal detachment of the macula as the only ocular manifestation of cat scratch disease. this diagnosis was made by serum antibody titers and the clinical course. discussion: although uncommon, cat scratch disease should be considered in patients with a serous detachment in the macula region of the retina.200617199167
[phlebotomine sandflies and transmission of disease agents around the mediterranean basin].around 800 species of phlebotomine sandflies are widely distributed in tropical and temperate areas. some sand flies are documented vectors of human disease agents including parasitic protozoa, (leishmania spp), bacteria (bartonella bacilliformis) and viruses (phlebovirus). in addition to presenting morphologic, taxonomic and biologic aspects of phlebotomine sandflies, this report focuses on ecologic, epidemiologic, ethologic, and anthropic factors contributing to the proliferation of sand flies ...200617201284
the low seroprevalence of tick-transmitted agents of disease in dogs from southern ontario and quebec.infectious diseases caused by pathogens transmitted by ticks and other insect vectors are an important cause of morbidity and mortality in both dogs and humans throughout north america. the purpose of this study was to determine the seroprevalence of selected vector-transmitted pathogens in southern ontario and quebec. samples submitted to the vector borne disease diagnostic laboratory (vbddl) at the north carolina state university college of veterinary medicine were evaluated for antibodies to ...200617217089
[rash and purulent lymphadenitis in cat scratch disease].we present a case of a cat-scratch disease (csd) presenting with typical (primary lesion and regional lymphadenitis) and rare (purulent lymphadenitis and maculopapular rash) symptoms and positive epidemiological data. laboratory blood test showed normal values for routine parameters, except for mild leukocytosis (l 12.4 x 10(9)), elevated erythrocyte sedimentation rate (se 65/h) and moderately elevated asparta e-aminotransferase and alanine-aminotransferase values (ast/alt 48/90), fibrinogen (5. ...200617217106
diversity of bartonella genotypes in richardson's ground squirrel populations.the diversity and dynamics of bartonella genotypes found in wild richardson's ground squirrels (rgs), spermophilus richardsonii were monitored at multiple sites in saskatchewan, canada from 2002 to 2004. based on sequence analysis of a portion of the bartonella citrate synthase (glta) gene, four different genotypes were detected in 233 isolates from 176 animals. the majority (87%) of sequences were identified as genotype h, with genotypes i, j, and k accounting for 8%, 4%, and 1% of sequences, r ...200617187575
serologic survey of eptesicus fuscus from georgia, u.s.a. for rickettsia and borrelia and laboratory transmission of a rickettsia by bat ticks.bats and their ectoparasites are associated with bacterial agents of unknown pathogenicity. we tested sera from 56 eptesicus fuscus from georgia against borrelia hermsii, orientia tsutsugamushi, rickettsia conorii, and rickettsia rickettsii. we detected antibodies reactive against a relapsing fever borrelia and spotted fever group rickettsia in 3/56 and 1/56 bats, respectively. we attempted to culture bartonella from the blood of these bats but were unsuccessful. in addition, we fed bat ticks, c ...200617249357
bartonella infections in fleas (siphonaptera: pulicidae) and lack of bartonellae in ticks (acari: ixodidae) from hungary.fleas (95 pulex irritans, 50 ctenocephalides felis, 45 ctenocephalides canis) and ixodid ticks (223 ixodes ricinus, 231 dermacentor reticulatus, 204 haemaphysalis concinna) were collected in hungary and tested, in assays based on pcr, for bartonella infection. low percentages of p. irritans (4.2%) and c. felis (4.0%) were found to be infected. the groel sequences of the four isolates from p. irritans were different from all the homologous sequences for bartonellae previously stored in genbank bu ...200617252927
demographic features of bartonella infections in richardson's ground squirrels (spermophilus richardsonii).the epidemiology of bartonella infections in richardson's ground squirrels (spermophilus richardsonii) was studied at multiple sites in saskatchewan, canada, from 2002 to 2004. the overall prevalence of bartonella infection was 48%. juvenile squirrels were significantly more likely to be infected with bartonella than were adults (58% and 37%, respectively), and juvenile animals also were significantly more likely to have high levels of bacteremia compared to adult animals. prevalence of bartonel ...200617255440
effect of experimental ectoparasite control on bartonella infections in wild richardson's ground squirrels.the purpose of this study was to investigate the role of ectoparasites in transmitting bartonella infections in wild richardson's ground squirrels (spermophilus richardsonii). richardson's ground squirrels were trapped, examined for fleas, and tested for bartonella bacteremia once monthly, at six sites, from april to september 2004. after the initial trapping session in april, burrows at three sites were treated with deltamethrin insecticide. richardson's ground squirrels trapped on treated site ...200617255441
high suspicion of bacillary angiomatosis in a kidney transplant recipient: a difficult way to diagnose--case report.bacillary angiomatosis is an infection caused by bartonella, which has first been described in human immunodeficiency virus (hiv)-infected patients. we report an unusually located lesion, in a totally asymptomatic kidney transplant recipient. the diagnosis was strongly suggested based on the iconography and our histological analysis, but was not confirmed using polymerase chain reaction (pcr) and immunohistochemical studies. we illustrate our difficult way to the diagnosis as well as the course ...200717275532
haemoparasites of common shrews (sorex araneus) in northwest england.the presence of haemoparasites belonging to the taxa anaplasma, bartonella and trypanosoma was determined among 76 common shrews (sorex araneus) from northwest england. anaplasma phagocytophilum dna was recovered from the blood of 1 shrew (1.3%), with the amplified 16s rrna sequence identical to one previously reported from a bank vole (clethrionomys glareolus). trypanosoma spp. dna was detected in 9 shrews (11.8%), the amplified 18s rdna fragments being indistinguishable from one another, and d ...200717288633
bartonella henselae infection in splenectomized domestic cats previously infected with hemotropic mycoplasma species.cat scratch disease is caused by bartonella henselae and the domestic cat represents its main reservoir. in immunocompromised patients, infection with b. henselae is characterized by more severe clinical forms than in non-immunocompromised individuals. the objective of the present study was to investigate the characteristics of b. henselae (houston-i strain) infection in four splenectomized and three non-splenectomized cats, five of which were chronically infected with 'candidatus mycoplasma hae ...200717254639
an immunohistochemical and polymerase chain reaction evaluation of feline plasmacytic pododermatitis.sections of 14 skin biopsies of cats with plasmacytic pododermatitis and a clinical follow-up of 12-36 months were stained with a polyclonal anti-mycobacterium bovis (bacille calmette-guerin = bcg) antibody cross-reactive to a broad spectrum of fungi and bacteria. all sections were negative for organisms within the actual footpad tissue with the anti-bcg antibody stains. polymerase chain reaction (pcr) assays that amplify the dna of bartonella spp., ehrlichia spp., anaplasma phagocytophilum, chl ...200717197627
a survey of zoonotic pathogens carried by norway rats in baltimore, maryland, usa.norway rats (rattus norvegicus) carry several zoonotic pathogens and because rats and humans live in close proximity in urban environments, there exists potential for transmission. to identify zoonotic agents carried by rats in baltimore, maryland, usa, we live-trapped 201 rats during 2005-2006 and screened them for a panel of viruses, bacteria, and parasites. antibodies against seoul virus (57.7%), hepatitis e virus (hev, 73.5%), leptospira interrogans (65.3%), bartonella elizabethae (34.1%), a ...200717224086
rickettsial pathogens in the tropical rat mite ornithonyssus bacoti (acari: macronyssidae) from egyptian rats (rattus spp.).we collected and tested 616 tropical rat mites (ornithonyssus bacoti (hirst)) from rats (rattus norvegicus (berkenhout) and r. rattus (linnaeus)) throughout 14 governorates in egypt and tested dna extracts from pools of these mites for bartonella spp., coxiella burnetii, and rickettsia spp. by pcr amplification and sequencing. three different mite-associated bacterial agents, including one bartonella and two rickettsia spp., were detected in eight pools of mites. further research could demonstra ...200717225079
cat-scratch disease relapse in a kidney transplant recipient.cat-scratch disease, an infectious illness infrequently reported in kidney transplant patients, is caused by the organism bartonella henselae and is transmitted through contact with cats or kittens. it is a self-limited disorder in the general pediatric population. here we present a case of unsuspected cat-scratch disease in a pediatric kidney transplant patient who presented with fever and lymphadenopathy. eight months after treatment with a short course of azithromycin, the patient developed a ...200717239132
cat scratch disease causing hepatic masses after liver transplant.hepatic cat scratch disease is rarely reported in liver transplant recipients and has never been reported with discrete liver lesions in the graft. a 52-year-old woman was transplanted for hepatitis c cirrhosis and hepatocellular carcinoma. her posttransplant course was uneventful. she presented 2.7 years after transplantation with fever of unknown origin and went on to develop multiple and diffuse discrete liver lesions. despite an extensive work-up including percutaneous and laparoscopic biops ...200717241393
pyogenic splenic abscess in an infant with serological evidence of cat scratch disease. 200717186270
contrasting dynamics of bartonella spp. in cyclic field vole populations: the impact of vector and host dynamics.many zoonotic disease agents are transmitted between hosts by arthropod vectors, including fleas, but few empirical studies of host-vector-microparasite dynamics have investigated the relative importance of hosts and vectors. this study investigates the dynamics of 4 closely related bartonella species and their flea vectors in cyclic populations of field voles (microtus agrestis) over 3 years. the probability of flea infestation was positively related to field vole density 12 months previously i ...200717096870
bone marrow and skin granulomatosis in a patient with bartonella infection.this report describes a case of granulomatous inflammation, involving the bone marrow and skin, due to bartonella infection in an immunocompetent patient. the clinical presentation included prolonged fever, pancytopenia, rash and hepatitis. bartonella infection should thus be added to the growing list of entities that produce marrow granulomas and fever.200717172528
effect of high-dose methyl-prednisolone on brainstem encephalopathy and basal ganglia impairment complicating cat scratch disease.cat scratch disease (csd) is a zoonotic illness caused by the gram negative bacillus bartonella henselae characterized by a small skin lesion at the site of a bite, lick or scratch by a cat, commonly followed by regional lymphadenopathy 1 or 2 weeks later. we report herein on severe neurological complications of csd combining brainstem encephalopathy and basal ganglia impairment. this 12-year-old female acutely presented to a local hospital with profound coma and a prolonged tonic posturing of e ...200717174500
an unusual cutaneous presentation of cat-scratch disease. 200717176268
isolation of bartonella quintana from a woman and a cat following putative bite transmission.we report here the detection of bartonella quintana, after putative bite transmission, in pre-enrichment blood cultures from a woman and from two feral barn cats. prospective molecular epidemiological studies are necessary to characterize the risk of human bartonella quintana infection following cat bites.200717093037
the identification of two protective dna vaccines from a panel of five plasmid constructs encoding brucella melitensis 16m genes.five candidate genes from the brucella melitensis 16m genome were selected. eukaryotic expression plasmids encoding these antigens were constructed and expression was verified in vitro from transfected cos7 cells. each vaccine was assessed for protective efficacy in a balb/c mouse brucellosis infection model. from these experiments two protective dna vaccines were identified: p-omp25 and p-ialb. the omp25 antigen (bmei1249) has previously been studied in terms of brucella virulence, serodiagnosi ...200717049676
analysis of bartonella adhesin a expression reveals differences between various b. henselae strains.bartonella henselae causes cat scratch disease and the vasculoproliferative disorders bacillary angiomatosis and peliosis hepatis in humans. one of the best known pathogenicity factors of b. henselae is bartonella adhesin a (bada), which is modularly constructed, consisting of head, neck/stalk, and membrane anchor domains. bada is important for the adhesion of b. henselae to extracellular-matrix proteins and endothelial cells (ecs). in this study, we analyzed different b. henselae strains for ba ...200717060468
two cases of endocarditis due to bartonella henselae. 200717546106
bartonella-related pseudomembranous angiomatous papillomatosis of the oral cavity associated with allogeneic bone marrow transplantation and oral graft-versus-host disease.patients undergoing allogeneic stem cell transplantation are at high risk for infection with a variety of pathogens during different phases of the procedure. human infections due to bartonella spp. are viewed as emerging diseases typical in, although not exclusive to, immunosuppressed patients, in particular those with aids, organ transplants and haematological malignancies. we describe four patients, three children and one adult, who developed vegetating papillomatous lesions exclusively on the ...200717553040
bartonella species in blood of immunocompetent persons with animal and arthropod contact.using pcr in conjunction with pre-enrichment culture, we detected bartonella henselae and b. vinsonii subspecies berkhoffii in the blood of 14 immunocompetent persons who had frequent animal contact and arthropod exposure.200717553243
gray foxes (urocyon cinereoargenteus) as a potential reservoir of a bartonella clarridgeiae-like bacterium and domestic dogs as part of a sentinel system for surveillance of zoonotic arthropod-borne pathogens in northern california.two species of bartonella, a novel bartonella clarridgeiae-like bacterium and b. vinsonii subsp. berkhoffii, were isolated from rural dogs and gray foxes in northern california. a novel b. clarridgeiae-like species was isolated from 3 (1.7%) of 182 dogs and 22 (42%) of 53 gray foxes, while b. vinsonii subsp. berkhoffii was isolated from 1 dog (0.5%) and 5 gray foxes (9.4%). pcr and dna sequence analyses of the citrate synthase (glta) gene and the 16s-23s intergenic spacer region suggested that s ...200717553970
discovery of new infectious diseases - bartonella species. 200717554115
bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species.bartonella species cause serious human infections globally, including bacillary angiomatosis, oroya fever, trench fever, and endocarditis. we describe a patient who had fever and splenomegaly after traveling to peru and also had bacteremia from an organism that resembled bartonella bacilliformis, the causative agent of oroya fever, which is endemic to peru. however, genetic analyses revealed that this fastidious bacterium represented a previously uncultured and unnamed bartonella species, closel ...200717554119
[bartonella infection in hematological practice].to characterize the clinical and histological features of bartonella infection in patients asking for hematological advice and to assess the significance of serological and molecular methods for the diagnosis of this infection.200717564022
[cat scratch disease]. 200717569180
images in emergency medicine. bartonella henselae lymphadenitis. 200717572294
transcriptional regulation of the heme binding protein gene family of bartonella quintana is accomplished by a novel promoter element and iron response regulator.we previously identified a five-member family of hemin-binding proteins (hbp's) of bartonella quintana that bind hemin on the outer surface but share no homology with known bacterial heme receptors. subsequently, we demonstrated that expression of the hbp family is significantly influenced by oxygen, heme, and temperature conditions encountered by the pathogen in the human host and the body louse vector; e.g., we observed a dramatic (>100-fold) increase in hbpc transcript levels in response to t ...200717576755
counterpoint: long-term antibiotic therapy improves persistent symptoms associated with lyme disease.controversy exists regarding the diagnosis and treatment of lyme disease. patients with persistent symptoms after standard (2-4-week) antibiotic therapy for this tickborne illness have been denied further antibiotic treatment as a result of the perception that long-term infection with the lyme spirochete, borrelia burgdorferi, and associated tickborne pathogens is rare or nonexistent.200717578772
bartonella dna in loggerhead sea turtles. 200717582905
canine bartonellosis: serological and molecular prevalence in brazil and evidence of co-infection with bartonella henselae and bartonella vinsonii subsp. berkhoffii.the purpose of this study was to determine the serological and molecular prevalence of bartonella spp. infection in a sick dog population from brazil. at the são paulo state university veterinary teaching hospital in botucatu, 198 consecutive dogs with clinicopathological abnormalities consistent with tick-borne infections were sampled. antibodies to bartonella henselae and bartonella vinsonii subsp. berkhoffii were detected in 2.0% (4/197) and 1.5% (3/197) of the dogs, respectively. using 16s-2 ...200717583666
utility of mr imaging in cat-scratch neuroretinitis.about 80% of cat-scratch disease (csd) infections occur in children, and csd neuroretinitis (optic neuropathy with retinal exudates in a "macular star" pattern) mostly occurs in children and young adults. a recent study suggested that csd optic neuropathy has specific features on mr imaging. however, mr imaging findings in csd neuroretinitis are not well described in the pediatric literature. we present a patient with csd neuroretinitis in whom these specific mr imaging features preceded the mac ...200717583805
microarray for serotyping of bartonella species.bacteria of the genus bartonella are responsible for a large variety of human and animal diseases. serological typing of bartonella is a method that can be used for differentiation and identification of bartonella subspecies.200717593301
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