Publications

daily marital interaction quality and carotid artery intima-medial thickness in healthy middle-aged adults.	to examine the association between marital interaction quality during daily life and subclinical cardiovascular disease (cvd). studies have shown that marital status and quality of marriage are associated with cardiovascular health. however, little is known about the role of marital interaction quality during daily life in contributing to these effects.	24915293
hiv risk practices by female sex workers according to workplace.	objective to investigate differences in hiv infection- related risk practices by female sex workers according to workplace and the effects of homophily on estimating hiv prevalence. methods data from 2,523 women, recruited using respondent-driven sampling, were used for the study carried out in 10 brazilian cities in 2008-2009. the study included female sex workers aged 18 and over. the questionnaire was completed by the subjects and included questions on characteristics of professional activity ...	25119937
cross-cultural validity of the demand-control questionnaire: swedish and brazilian workers.	objective to evaluate the cross-cultural validity of the demand-control questionnaire, comparing the original swedish questionnaire with the brazilian version. methods we compared data from 362 swedish and 399 brazilian health workers. confirmatory and exploratory factor analyses were performed to test structural validity, using the robust weighted least squares mean and variance-adjusted (wlsmv) estimator. construct validity, using hypotheses testing, was evaluated through the inspection of the ...	25119944
evaluation of protective efficacy of avicennia marina (forssk.) vierh leaves against complete freund᾽s adjuvant-induced arthritis in wistar.	aviecennia marina (avicenniaceae) is an endemic plant that widely distributed in the southern parts of iran. this plant has been used as treatment of rheumatism arthritis among the inhabitants of southern parts of iran. the avicennia marina hydroalcoholic extract was prepared and its protective efficacy was investigated using measurement of ankle diameter, total wbc and rbc count, esr, and pro-inflammatory cytokines levels in the complete freund᾽s adjuvant (cfa)-induced arthritic rat. the increm ...	25276195
assessing appearance-related disturbances in hiv-infected men who have sex with men (msm): psychometrics of the body change and distress questionnaire-short form (abcd-sf).	appearance-related disturbances are common among hiv-infected msm; however, to date, there have been limited options in the valid assessment of this construct. the aim of the current study was to assess the structural, internal, and convergent validity of the assessment of body change distress questionnaire (abcd) and its short version. exploratory and confirmatory factor analyses indicated that both versions fit the data well. four subfactors were revealed measuring the following body disturban ...	24057934
global self-esteem and method effects: competing factor structures, longitudinal invariance, and response styles in adolescents.	the rosenberg self-esteem scale (rses) is a widely used measure for assessing self-esteem, but its factor structure is debated. our goals were to compare 10 alternative models for the rses and to quantify and predict the method effects. this sample involves two waves (n =2,513 9th-grade and 2,370 10th-grade students) from five waves of a school-based longitudinal study. the rses was administered in each wave. the global self-esteem factor with two latent method factors yielded the best fit to th ...	24061931
cognitive, affective and eudemonic well-being in later life: measurement equivalence over gender and life stage.	the hedonic view on well-being, consisting of both cognitive and affective aspects, assumes that through maximizing pleasurable experiences, and minimizing suffering, the highest levels of well-being can be achieved. the eudemonic approach departs from the concept of a good life that is not just about pleasure and happiness, but involves developing one-self, being autonomous and realizing one's potential. while these approaches are often positioned against each other on theoretical grounds, this ...	27429579
construct validity of the chinese version of the psycho-educational profile-3rd edition (cpep-3).	objective behavioral assessment of autism spectrum disorder (asd) in early childhood is essential for guiding appropriate treatment and intervention. in contrast to western societies, validated measures of asd are very limited in different chinese contexts. the present study attempted to examine the construct validity of the chinese version of psycho-educational profile-3rd edition (cpep-3). the cpep-3 was administered to a sample of 455 children with asd and a comparison group of 281 children w ...	24838124
carbohydrate antigen delivery by water soluble copolymers as potential anti-cancer vaccines.	tumor associated carbohydrate antigens (tacas) are overexpressed on tumor cells, which renders them attractive targets for anti-cancer vaccines. to overcome the poor immunogenicity of tacas, we designed a polymer platform for antigen presentation by co-delivering taca and helper t (th) cell epitope on the same chain. the block copolymer was synthesized by cyanoxyl-mediated free radical polymerization followed by conjugation with a taca tn antigen and a mouse th-cell peptide epitope derived from ...	25396038
anti-arthritis effects of (e)-2,4-bis(p-hydroxyphenyl)-2-butenal are mediated by inhibition of the stat3 pathway.	products of maillard reactions between aminoacids and reducing sugars are known to have anti-inflammatory properties. here we have assessed the anti-arthritis effects of (e)-2,4-bis(p-hydroxyphenyl)-2-butenal and its possible mechanisms of action.	24520814
spectrum of genes involved in a unique case of potocki schaffer syndrome with a large chromosome 11 deletion.		24780589
social integration and the mental health of black adolescents.	the influence of family, school, and religious social contexts on the mental health of black adolescents has been understudied. this study used durkheim’s social integration theory to examine these associations in a nationally representative sample of 1,170 black adolescents, ages 13–17. mental health was represented by positive and negative psychosocial well-being indicators. results showed that adolescents’ integration into family and school were related to better mental health. in addition, c ...	24815855
the promis physical function item bank was calibrated to a standardized metric and shown to improve measurement efficiency.	to document the development and psychometric evaluation of the patient-reported outcomes measurement information system (promis) physical function (pf) item bank and static instruments.	24698295
editorial: interferon-γ: friend or foe in systemic juvenile idiopathic arthritis and adult-onset still's disease?		24470448
understanding the complexities of functional ability in alzheimer's disease: more than just basic and instrumental factors.	dementia of the alzheimer's type (ad) is defined by both cognitive and functional decline; new criteria allow for identification of milder, non-functionally impaired patients. understanding loss of autonomy in ad is essential, as later stages represent a significant burden and cost to patients, their families, and society. the purpose of the present analyses was to determine the factor structure of the alzheimer's disease cooperative study-activities of daily living scale (adcs-adl) in a cohort ...	24635843
who sees human? the stability and importance of individual differences in anthropomorphism.	anthropomorphism is a far-reaching phenomenon that incorporates ideas from social psychology, cognitive psychology, developmental psychology, and the neurosciences. although commonly considered to be a relatively universal phenomenon with only limited importance in modern industrialized societies-more cute than critical-our research suggests precisely the opposite. in particular, we provide a measure of stable individual differences in anthropomorphism that predicts three important consequences ...	24839457
achievement-relevant personality: relations with the big five and validation of an efficient instrument.	many achievement-relevant personality measures (apms) have been developed, but the interrelations among apms or associations with the broader personality landscape are not well-known. in study 1, 214 participants were measured on 36 apms and a measure of the big five. factor analytic results supported the convergent and discriminant validity of five latent dimensions: performance, mastery, self-doubt, effort, and intellectual investment. conscientiousness, neuroticism, and openness to experience ...	24839374
parental etiological explanations and longitudinal medication use for youths with attention deficit hyperactivity disorder.	due to the need to increase understanding of factors associated with medication usage for youth with adhd, this study examined parental explanatory etiologies in relationship to psychotropic medication use in a sample of youth who met criteria for adhd and utilized outpatient specialty mental health services in the previous year. when examined cross-sectionally, medication usage was positively associated with parental explanatory etiologies related to physical causes and negatively associated wi ...	23504264
understanding conscientiousness across the life course: an economic perspective.	we discuss recent developments in the literature on the role of conscientiousness on healthy aging within an economic framework that helps to systematize and interpret the existing evidence.	24773106
effect of aqueous extract of achillea millefolium on the development of experimental autoimmune encephalomyelitis in c57bl/6 mice.	achillea millefolium (a. millefolium) is widely used as an anti-inflammatory remedy in traditional and herbal medicine. in this study, we investigated the effect of an aqueous extract from a. millefolium on experimental autoimmune encephalomyelitis (eae) and on the serum cytokine levels in c57bl/6 mice.	24987178
calcium intervention ameliorates experimental model of multiple sclerosis.	multiple sclerosis (ms) is the most common inflammatory disease of the cns. experimental autoimmune encephalomyelitis (eae) is a widely used model for ms. in the present research, our aim was to test the therapeutic efficacy of calcium (ca) in an experimental model of ms.	24936267
transient receptor potential (trp) channels: a clinical perspective.	transient receptor potential (trp) channels are important mediators of sensory signals with marked effects on cellular functions and signalling pathways. indeed, mutations in genes encoding trp channels are the cause of several inherited diseases in humans (the so-called 'trp channelopathies') that affect the cardiovascular, renal, skeletal and nervous systems. trp channels are also promising targets for drug discovery. the initial focus of research was on trp channels that are expressed on noci ...	24102319
high salt intake does not exacerbate murine autoimmune thyroiditis.	recent studies have shown that high salt (hs) intake exacerbates experimental autoimmune encephalomyelitis and have raised the possibility that a hs diet may comprise a risk factor for autoimmune diseases in general. in this report, we have examined whether a hs diet regimen could exacerbate murine autoimmune thyroiditis, including spontaneous autoimmune thyroiditis (sat) in non-obese diabetic (nod.h2(h4)) mice, experimental autoimmune thyroiditis (eat) in c57bl/6j mice challenged with thyroglob ...	24528002
a novel pathogenic peptide of thyroglobulin (2208-2227) induces autoreactive t-cell and b-cell responses in both high and low responder mouse strains.	experimental autoimmune thyroiditis (eat) is commonly induced by thyroglobulin (tg) or tg peptides in mice genetically susceptible to thyroiditis. in the present study, we investigated the immunogenic and pathogenic potential of a novel 20mer human tg peptide, p2208 (amino acids 2208-2227), in mouse strains classified as low (lr) or high (hr) responders in eat. the peptide was selected for its content in overlapping binding motifs for mhc class ii products, associated with either resistance (a(b ...	24758369
correlation not causation: the relationship between personality traits and political ideologies.	the assumption in the personality and politics literature is that a person's personality motivates them to develop certain political attitudes later in life. this assumption is founded on the simple correlation between the two constructs and the observation that personality traits are genetically influenced and develop in infancy, whereas political preferences develop later in life. work in psychology, behavioral genetics, and recently political science, however, has demonstrated that political ...	22400142
innate-adaptive crosstalk: how dendritic cells shape immune responses in the cns.	dendritic cells (dcs) are a heterogeneous group of professional antigen presenting cells that lie in a nexus between innate and adaptive immunity because they recognize and respond to danger signals and subsequently initiate and regulate effector t-cell responses. initially thought to be absent from the cns, both plasmacytoid and conventional dcs as well as dc precursors have recently been detected in several cns compartments where they are seemingly poised for responding to injury and pathogens ...	21948376
fast synaptic inhibition in spinal sensory processing and pain control.	the two amino acids gaba and glycine mediate fast inhibitory neurotransmission in different cns areas and serve pivotal roles in the spinal sensory processing. under healthy conditions, they limit the excitability of spinal terminals of primary sensory nerve fibers and of intrinsic dorsal horn neurons through pre- and postsynaptic mechanisms, and thereby facilitate the spatial and temporal discrimination of sensory stimuli. removal of fast inhibition not only reduces the fidelity of normal senso ...	22298656
how communities can control trachoma without a big budget.		23520428
mouse models of multiple sclerosis: experimental autoimmune encephalomyelitis and theiler's virus-induced demyelinating disease.	experimental autoimmune encephalomyelitis (eae) and theiler's murine encephalitis virus-induced demyelinating disease (tmev-idd) are two clinically relevant murine models of multiple sclerosis (ms). like ms, both are characterized by mononuclear cell infiltration into the cns and demyelination. eae is induced by either the administration of myelin protein or peptide in adjuvant or by the adoptive transfer of encephalitogenic t cell blasts into naïve recipients. the relative merits of each of the ...	22933080
greater precision when measuring dementia severity: establishing item parameters for the clinical dementia rating scale.	an item response theory (irt)-based scoring approach to the clinical dementia rating scale (cdr) can account for the pattern of scores across the cdr items (domains) and their differential abilities to indicate dementia severity. in doing so, an irt-based approach can provide greater precision than other cdr scoring algorithms. however, neither a good set of item parameters nor an easily digestible set of instructions needed to implement this approach is readily available.	23006935
strengthening effective parenting practices over the long term: effects of a preventive intervention for parentally bereaved families.	this study tested the effect of the family bereavement program (fbp), a preventive intervention for bereaved families, on effective parenting (e.g., caregiver warmth, consistent discipline) 6 years after program completion. families (n = 101; 69% female caregivers; 77% caucasian, 11% hispanic) with children between ages 8 and 16 who had experienced the death of one parent were randomized to the fbp (n = 54) or a literature control condition (n = 47). multiple regression analyses conducted within ...	22417191
psychometric evaluation of the revised attribution questionnaire (r-aq) to measure mental illness stigma in adolescents.	the revised attribution questionnaire (r-aq) measures mental illness stigma. this study's purpose is to evaluate the factor structure of the (r-aq) and examine the validity of the factor structure in adolescents. a convenience sample (n = 210) of adolescents completed the r-aq and these data were used in exploratory (efa) and confirmatory factor analyses (cfa). the efa established a five item single factor structure, which we called the modified r-aq and captures the negative emotional reactions ...	22679709
animal models of antineutrophil cytoplasm antibody-associated vasculitis.	to provide an update on the experimental models that have been developed recapitulating clinical antineutrophil cytoplasm antibody (anca) associated vasculitis. the application of the models in the study of pathogenesis, and the therapeutic implications of this, are covered in the article by van timmeren and heeringa in this issue.	22089094
enhanced growth of primary tumors in cancer-prone mice after immunization against the mutant region of an inherited oncoprotein.	one major objective of tumor immunologists is to prevent cancer development in individuals at high risk. (tg.ac x c57bl/6)f1 mice serve as a model for testing the feasibility of this objective. the mice carry in the germline a mutant ras oncogene that has an arginine at codon 12 instead of glycine present in the wild-type, and after physical (wounding) or chemical promotion, these mice have a high probability for developing papillomas that progress to cancer. furthermore, f1 mice immunized with ...	10839809
monoclonal antibodies.	monoclonal antibodies are essential tools for many molecular immunology investigations. in particular, when used in combination with techniques such as epitope mapping and molecular modelling, monoclonal antibodies enable the antigenic profiling and visualisation of macromolecular surfaces. in addition, monoclonal antibodies have become key components in a vast array of clinical laboratory diagnostic tests. their wide application in detecting and identifying serum analytes, cell markers, and pat ...	10897328
estrogen potentiates treatment with t-cell receptor protein of female mice with experimental encephalomyelitis.	transgenic mice expressing the bv8s2 chain, which is specific for the myelin basic protein determinant ac1-11, possess a naturally induced set of regulatory t cells directed against bv8s2. further activation of anti-bv8s2 t cells in male mice with recombinant bv8s2 protein can inhibit ifn-gamma release by ac1-11-specific t cells through a cytokine-driven mechanism and prevent induction of experimental autoimmune encephalomyelitis (eae). in contrast, naive female mice possess fewer anti-bv8s2-rea ...	10811854
evaluating the equivalence of health care ratings by whites and hispanics.	this study was designed to assess the equivalence of a health care ratings scale administered to non-hispanic white and hispanic survey respondents.	10800978
the bristol shared care glaucoma study: outcome at follow up at 2 years.	to examine the outcome of care for patients with glaucoma followed up by the hospital eye service compared with those followed up by community optometrists.	10781507
fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific t cell receptor.	proteolipid protein (plp)-139-151 is the dominant encephalitogenic peptide that induces experimental autoimmune encephalomyelitis (eae) in sjl (h-2(s)) mice. to examine the contribution of t cell receptor (tcr) specificity in the induction of eae, we generated transgenic mice expressing the rearranged tcr genes from an encephalitogenic or a nonencephalitogenic plp-139-151/i-a(s)-specific t cell clone. both types of transgenic lines developed spontaneous eae, but, remarkably, the lines expressing ...	10737797
induction and suppression of an autoimmune disease by oligomerized t cell epitopes: enhanced in vivo potency of encephalitogenic peptides.	t cell epitope peptides derived from proteolipid protein (plp139-151) or myelin basic protein (mbp86-100) induce experimental autoimmune encephalomyelitis (eae) in "susceptible" strains of mice (e.g., sjl/j). in this study, we show that the encephalitogenic effect of these epitopes when injected subcutaneously in complete freund's adjuvant was significantly enhanced if administered to the animal in a multimerized form as a t cell epitope oligomer (i.e., as multiple repeats of the peptide epitope ...	10684863
adult familial cryptogenic fibrosing alveolitis in the united kingdom.	familial cases of cryptogenic fibrosing alveolitis (cfa) have previously been reported; however, the prevalence and genetic background of this disorder are not known. the clinical and epidemiological findings of 25 families identified within the uk are reported.	10639533
mucosally induced immunoglobulin e-associated inflammation in the respiratory tract.	the purpose of the present study was to determine the immunologic responses, particularly immunopathologic reactions, associated with nasal immunization with the mucosal adjuvant, cholera toxin (ct). balb/c mice were nasally immunized with tetanus toxoid (tt) combined with ct, and the responses of these mice were determined. after nasal immunization, mice produce a serum antibody response, primarily of the immunoglobulin g (igg) isotype of predominantly igg1 subclass, against both tt and ct. alo ...	10639432
deterioration in the nutritional status of young children and their mothers in brazzaville, congo, following the 1994 devaluation of the cfa franc.	the effects of the january 1994 devaluation of the african financial community (cfa) franc on the nutritional situation of the populations concerned has been little documented. we report in this article on two nutritional cross-sectional surveys that were conducted before and after this devaluation (1993 and 1996) in two districts of brazzaville, congo. the surveys involved a representative sample of 4206 households with a child aged 4-23 months. complementary feeding practices and the anthropom ...	10686745
early experience with the talent stent-graft system for endoluminal repair of abdominal aortic aneurysms.		10928500
anterior chamber-associated immune deviation-inducing cells activate t cells, and rescue them from antigen-induced apoptosis.	immune responses to antigens injected into the anterior chamber of the eye are devoid of t helper 1 (th1)-type responses of the delayed hypersensitivity type, which has been termed anterior chamber-associated immune deviation (acaid). recently, it has been found that peritoneal exudate cells (pec) from normal mice can be made to acquire the capacity to induce acaid in vivo when the cells are pulsed with antigen in vitro in the presence of transforming growth factor-beta2 (tgf-beta2), a major cyt ...	10594691
contribution of mast cells to the t helper 2 response induced by simultaneous subcutaneous and oral immunization.	this work examines the contribution of mast cells to the synergistic enhancement of the t helper 2 (th2) immune response elicited following simultaneous oral and subcutaneous (s.c.) immunization. the s.c. route induced a th1-biased immune response, characterized by increased interferon-gamma (ifn-gamma) and immunoglobulin g2a (igg2a) antibody production. in contrast, oral immunization stimulated a primarily th2-type response in which interleukin-4 (il-4) and igg1 antibody production were dominan ...	10594683
homeostatic expansion and phenotypic conversion of naïve t cells in response to self peptide/mhc ligands.	recent data suggest that survival of resting, naïve t cells requires an interaction with self mhc molecules. from analysis of the class i mhc-restricted t cell receptor transgenic strain ot-i, we report a different response. rather than merely surviving, these t cells proliferated slowly after transfer into t-depleted syngeneic hosts. this expansion required both t cell "space" and expression of normal levels of self class i mhc molecules. furthermore, we demonstrate that during homeostatic expa ...	10557316
the stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant t cell epitope.	h-2k mice injected, intravenously in saline or intraperitoneally in incomplete freund's adjuvant, with large quantities of the immunodominant i-e(k)-restricted epitope from moth cytochrome c (mcc) 88-103 fail to respond to subsequent immunization with this epitope when administered in complete freund's adjuvant. this state of tolerance can be broken by immunization with certain mcc 88-103 analogues that are heteroclitic antigens as assessed on representative mcc 88-103 specific t cell clones. in ...	10510088
nutritional status and mortality of refugee and resident children in a non-camp setting during conflict: follow up study in guinea-bissau.	to study the effects on children of humanitarian aid agencies restricting help to refugee families (internally displaced people).	10506040
initial impact of the fast track prevention trial for conduct problems: i. the high-risk sample. conduct problems prevention research group.	fast track is a multisite, multicomponent preventive intervention for young children at high risk for long-term antisocial behavior. based on a comprehensive developmental model, intervention included a universal-level classroom program plus social skills training, academic tutoring, parent training, and home visiting to improve competencies and reduce problems in a high-risk group of children selected in kindergarten. at the end of grade 1, there were moderate positive effects on children's soc ...	10535230
an inverse relationship between t cell receptor affinity and antigen dose during cd4(+) t cell responses in vivo and in vitro.	multimeric peptide/class ii mhc staining reagents were synthesized and shown to bind with appropriate specificity to t cell hybridomas. a small, expanded population of t cells detected with one of these reagents in peptide-immunized c57bl/10 mice persisted for several months. this population expanded further on secondary immunization. equating the extent of binding of this reagent to t cell receptor affinity, we saw little correlation of immunizing peptide dose to t cell receptor affinity at the ...	10449771
triggering a second t cell receptor on diabetogenic t cells can prevent induction of diabetes.	in this paper, we test the hypothesis that triggering of a second t cell receptor (tcr) expressed on diabetogenic t cells might initiate the onset of diabetes. a cross between two tcr-transgenic strains, the bdc2.5 strain that carries diabetogenic tcrs and the a18 strain that carries receptors specific for c5, was set up to monitor development of diabetes after activation through the c5 tcr. f1 bdc2. 5 x a18 mice developed diabetes spontaneously beyond 3-4 mo of age. although their t cells expre ...	10449528
recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via t cell apoptosis.	galectin-1 (gal-1), a member of a family of conserved beta-galactoside-binding proteins, has been shown to induce in vitro apoptosis of activated t cells and immature thymocytes. we assessed the therapeutic effects and mechanisms of action of delivery of gal-1 in a collagen-induced arthritis model. a single injection of syngeneic dba/1 fibroblasts engineered to secrete gal-1 at the day of disease onset was able to abrogate clinical and histopathological manifestations of arthritis. this effect w ...	10430627
induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: the igg scaffold is important for induction and maintenance of immune hyporesponsiveness.	igg molecules can be highly tolerogenic carriers for associated antigens. previously, we reported that recipients of bone marrow or lipopolysaccharide-stimulated b-cell blasts, both of which were retrovirally gene-transferred with an immunodominant peptide in-frame with the variable region of a murine igg heavy chain, were rendered profoundly unresponsive to that epitope. to further investigate whether tolerance to larger molecules can be achieved via this approach and whether the igg scaffold i ...	10411923
ph-dependent peptide binding properties of the type i diabetes-associated i-ag7 molecule: rapid release of clip at an endosomal ph.	mhc class ii molecules and invariant chain assemble at a neutral ph in the endoplasmic reticulum and are transported to a low ph compartment where the invariant chain is trimmed to the class ii-associated invariant chain peptide (clip). for many major histocompatibility complex class ii molecules, dm is required for rapid removal of clip, which allows binding of antigenic peptides. since i-ag7 confers susceptibility to type i diabetes in nod mice, the biochemical requirements for peptide loading ...	10359576
t cell receptor beta chain lacking the large solvent-exposed cbeta fg loop supports normal alpha/beta t cell development and function in transgenic mice.	the striking and unique structural feature of the t cell receptor (tcr) beta chain is the bulky solvent-exposed fg loop on the cbeta domain, the size of almost half an immunoglobulin domain. the location and size of this loop suggested immediately that it could be a crucial structural link between the invariant cd3 subunits and antigen-recognizing alpha/beta chains during tcr signaling. however, functional analysis does not support the above notion, since transgene coding for tcr beta chain lack ...	10330447
stem cell factor-induced airway hyperreactivity in allergic and normal mice.	the induction of airway hyperreactivity during allergic responses involves multiple ill-defined mechanisms. recently a role for stem cell factor (scf) in the development of allergic eosinophilic airway inflammation has been identified. in the present study we demonstrate that scf has a role in both the inflammatory response and airway hyperreactivity. neutralization of scf or examination of scf-mutant mice, which were deficient in scf and pulmonary mast cells, demonstrated significant alteration ...	10233863
distinct roles for transforming growth factor-beta2 and tumour necrosis factor-alpha in immune deviation elicited by hapten-derivatized antigen-presenting cells.	the role of antigen-presenting cells (apc) in the induction of antigen-specific unresponsiveness was examined, using two functionally distinct murine macrophage hybridomas, #59 and #63 cells. derivatized with the hapten (dinitrofluorobenzene; dnfb), #59 cells induced contact hypersensitivity (ch) in mice. hapten-derivatized #63 cells failed to induce ch. instead, they prevented recipients from acquiring ch when exposed subsequently to a sensitizing dose of the hapten. similarly, hapten-derivatiz ...	10233718
angiotensin ii plays a pathogenic role in immune-mediated renal injury in mice.	several lines of evidence show the importance of angiotensin ii (aii) in renal injuries, especially when hemodynamic abnormalities are involved. to elucidate the role of aii in immune-mediated renal injury, we studied anti-glomerular basement membrane (gbm) nephritis in aii type 1a receptor (at1a)-deficient homozygous (at1a-/-) and wild-type (at1a+/+) mice. a transient activation of the renin-angiotensin system (ras) was observed in both groups of mice at around day 1. a renal expression of mono ...	10074479
dna vaccination: transfection and activation of dendritic cells as key events for immunity.	the mechanisms underlying initiation and maintenance of cd4 t cell responses after dna vaccination were studied using a construct coding for nonsecreted fifth component of complement (c5) protein, thus restricting the availability of antigen. the only cell types to express c5 were keratinocytes at the site of dna application and a small number of dendritic cells present in the draining lymph nodes. antigen expression persisted for up to 12 wk in keratinocytes, but dendritic cells did not express ...	9874573
thoughts of death and suicide in early adolescence.	the prevalence and persistence of thoughts of death and suicide during early adolescence were estimated in a community-based cohort. a latent class approach was used to identify distinct subgroups based on endorsements to depression items administered repeatedly over 24 months. two classes emerged, with 75% in a low ideation class across four assessments. less than 2% persisted in the high ideation class over three or more assessments. african american and asian american adolescents were more li ...	20121323
the bcl2 inhibitor abt-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitors.	bcr-abl1-specific tyrosine kinase inhibitors prolong the life of patients with chronic myeloid leukemia (cml) but cannot completely eradicate cml progenitors. the bh3 mimetic, abt-263, targets prosurvival bcl2 family members, and has activity against cml progenitors. however, the inhibitory effect of abt-263 on bcl-xl, which mediates platelet survival, produces dose-limiting thrombocytopenia. a second-generation bh3 mimetic, abt-199, has been developed to specifically bind bcl2 but not bcl-xl. w ...	25333252
symptom cluster analyses based on symptom occurrence and severity ratings among pediatric oncology patients during myelosuppressive chemotherapy.	symptom cluster research is an emerging field in symptom management. the ability to identify symptom clusters that are specific to pediatric oncology patients may lead to improved understanding of symptoms' underlying mechanisms among patients of all ages.	21921793
measuring teamwork and conflict among emergency medical technician personnel.	we sought to develop a reliable and valid tool for measuring teamwork among emergency medical technician (emt) partnerships.	22128909
an initial psychometric evaluation of the cbcl 6-18 in a sample of youth with autism spectrum disorders.	individuals with an autism spectrum disorder (asd) often present with co-occurring emotional and behavioral disorders (ebd). the child behavior checklist 6-18 (cbcl; achenbach & rescorla, 2001) is an ebd measure that contains several norm-referenced scales derived through factor analysis of data from the general pediatric population. the psychometric properties of this widely used and well-researched measure have not been evaluated in samples of youth with asd. this study evaluated the cbcl's in ...	22059091
characterization of cd4+ t-cell-dendritic cell interactions during secondary antigen exposure in tolerance and priming.	despite the recent advances in our understanding of the dynamics of the cellular interactions associated with the induction of immune responses, comparatively little is known about the in vivo behaviour of antigen-experienced t cells upon secondary antigen exposure in either priming or tolerance. such information would provide an insight into the functional mechanisms employed by memory t cells of distinct phenotypes and provide invaluable knowledge of how a specific tolerogenic or immunogenic s ...	19930039
visualizing recall immune responses with multi-photon microscopy.	multi-photon microscopy has increased our understanding of t-cell behaviour during the initiation of primary immune responses. in this issue of immunology a study uses real-time imaging of lymph nodes to observe and compare the early events in naive, tolerized and primed cd4 t-cell responses.	19930038
factorial invariance of the dyadic adjustment scale across gender.	the dyadic adjustment scale (das; g. b. spanier, 1976) is the most widely used inventory of relationship satisfaction in the social sciences, yet the question of whether it is measuring the same concept in men and women has never been addressed. in the current study, the authors examined the factor structure of the das in a sample of 900 currently married couples who participated in the minnesota twin family study. confirmatory factor analysis was applied to a second-order factor solution with s ...	19947795
relationship between neighborhood context, family management practices and alcohol use among urban, multi-ethnic, young adolescents.	we examined relationships between alcohol-related neighborhood context, protective home and family management practices, and alcohol use among urban, racial/ethnic minority, adolescents. the sample comprised 5,655 youth who were primarily low ses (72%), african american (43%) and hispanic (29%). participants completed surveys in 2002-2005 (ages 11-14 years). items assessed alcohol use, accessibility of alcohol at home and parental family management practices. neighborhood context measures includ ...	19381808
the curiosity and exploration inventory-ii: development, factor structure, and psychometrics.	given curiosity's fundamental role in motivation, learning, and well-being, we sought to refine the measurement of trait curiosity with an improved version of the curiosity and exploration inventory (cei; kashdan, rose, & fincham, 2004). a preliminary pool of 36 items was administered to 311 undergraduate students, who also completed measures of emotion, emotion regulation, personality, and well-being. factor analyses indicated a two factor model-motivation to seek out knowledge and new experien ...	20160913
a psychometric evaluation of the behavioral inhibition questionnaire in a non-clinical sample of dutch children and adolescents.	the behavioral inhibition questionnaire (biq) is a parent-rating scale for measuring temperamental characteristics referring to shyness, fearfulness, and withdrawal in young, preschool children. the present study evaluated the psychometric properties of the biq in a dutch community sample of children with a broad age range. for this purpose,the reliability and validity of the biq was evaluated in three age groups: 4-7-year-olds,8-11-year-olds, and 12-15-year-olds. the results indicated that the ...	19921537
fifteen years of progress in measurement and methods at the resource centers for minority aging research.		22904184
factor structure and reliability of the revised dyadic adjustment scale (rdas) in iranian population.	to determine the reliability and validity of the revised dyadic adjustment scale (rdas) with 14 items (short form) in iranian population.	24644483
the general environment fit scale: a factor analysis and test of convergent construct validity.	person-environment fit (p-e fit) was initially espoused as an important construct in the field of community psychology; however, most of the theoretical and empirical development of the construct has been conducted by the industrial/organizational (i/o) psychologists and business management fields. in the current study, the gefs-a p-e fit measure that was developed from organizational perspectives on fit-was administered to 246 attendees of an annual convention for residents and alumni of oxford ...	22071911
the consumer assessment of healthcare providers and systems (cahps) cultural competence (cc) item set.	there is a need for reliable and valid measures of cultural competence (cc) from the patient's perspective.	22895226
jekyll and hide: the two faces of amyloid β.	neurodegenerative diseases are a burden of our century. although significant efforts were made to find a cure or relief to this scourge, their pathophysiology remains vague and the cellular function of the key involved proteins is still unclear. however, in the case of amyloid β (aβ), a key protein concerned in alzheimer disease, we are now a step closer in the unscrambling of its cellular functions. interestingly, whereas the exact role of aβ in the pathophysiology of alzheimer disease is still ...	23181153
bat3 promotes t cell responses and autoimmunity by repressing tim-3–mediated cell death and exhaustion.	t cell immunoglobulin and mucin domain–containing 3 (tim-3) is an inhibitory receptor that is expressed on exhausted t cells during infection with hiv-1 and hepatitis c virus. by contrast, tim-3 expression and function are defective in multiple human autoimmune diseases. however, the molecular mechanisms modulating tim-3 function are not well understood. here we show that human leukocyte antigen b (hla-b)-associated transcript 3 (bat3) binds to, and represses the function of, tim-3. bat3 protect ...	22863785
the α7 nicotinic ach receptor agonist compound b and positive allosteric modulator pnu-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat.	agonists selective for the α7 nicotinic acetylcholine (nach) receptor produce anti-hyperalgesic effects in rodent models of inflammatory pain, via direct actions on spinal pain circuits and possibly via attenuated release of peripheral pro-inflammatory mediators. increasingly, allosteric modulation of ligand-gated receptors is recognized as a potential strategy to obtain desired efficacy in the absence of the putative adverse effects associated with agonist activation.	22536953
chronic pancreatitis.	we review important new clinical observations in chronic pancreatitis reported in 2011.	22782018
umyuangcaryaraq "reflecting": multidimensional assessment of reflective processes on the consequences of alcohol use among rural yup'ik alaska native youth.	concerns in some settings regarding the accuracy and ethics of employing direct questions about alcohol use suggest need for alternative assessment approaches with youth. umyuangcaryaraq is a yup'ik alaska native word meaning "reflecting."	22931081
evaluating measurement equivalence across race and ethnicity on the cahps cultural competence survey.	the consumer assessments of healthcare providers and systems (cahps) cultural competence survey assesses patients' experiences with culturally competent care. this study evaluates the equivalence of responses to this survey across different racial and ethnic subgroups. in this study, we examined whether measurement bias on the cahps cultural competence survey impedes valid measurement across white, black, and hispanic patients.	22895228
escherichia coli: a brief review of diarrheagenic pathotypes and their role in diarrheal diseases in iran.	diarrheagenic escherichia coli have developed different strategies for establishment of infection in their host. understanding these pathogenic mechanisms has led to the development of specific diagnostic tools for identification and categorization of e. coli strains into different pathotypes. this review aims to provide an overview of the various categories of diarrheagenic escherichia coli and the data obtained in iran pertaining to these pathotypes.	23066484
travelling fellowship program for football medicine; report on an experience.	football medicine has developed in the world in recent years. afc medical committee, established the idea of football medicine travelling fellowship two years ago and provided high-level healthcare services to football players in asian countries. this is a report on my one month experience in a travelling fellowship program for football medicine which is attempting to tell the reader about the interesting event that i experienced. this course has been held between jan 15 to feb 10, 2012 in 3 asi ...	23012644
does the consumer assessment of healthcare providers and systems cultural competence survey provide equivalent measurement across english and spanish versions?	the english and spanish versions of the consumer assessments of healthcare providers and systems (cahps) cultural competence survey (cahps-cc) assess patients' experiences with culturally competent care. the possibility exists that even when spanish and english speakers experience the same levels of culturally competent care, responses describing their care may differ. this is called measurement bias. to deliver reliable and valid information across language, responses must provide equivalent me ...	22895229
components of patient satisfaction with a dental restorative visit: results from the dental practice-based research network.	the authors conducted a study to identify components of patient satisfaction with restorative dental care and to test the hypothesis that certain dentist, patient and procedure factors are associated with patient satisfaction.	22942147
experimental autoimmune breast failure: a model for lactation insufficiency, postnatal nutritional deprivation, and prophylactic breast cancer vaccination.	mastitis is a substantial clinical problem in lactating women that may result in severe pain and abrupt termination of breastfeeding, thereby predisposing infants to long-term health risks. many cases of mastitis involve no known infectious agent and may fundamentally be due to autoimmune-mediated inflammation of the breast. herein, we develop a murine model of autoimmune mastitis and provide a detailed characterization of its resulting phenotype of breast failure and lactation insufficiency. to ...	22901749
isolation of antagonists of antigen-specific autoimmune t cell proliferation.	antigen-specific t cells play a major role in mediating the pathogenesis of a variety of autoimmune conditions as well as other diseases. in the context of experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis, we present here a general approach to the discovery of highly specific ligands for autoreactive cells. these ligands are obtained from a combinatorial library of hundreds of thousands of synthetic peptoids that is screened simultaneously against two populations o ...	19942136
graduate socialization in the responsible conduct of research: a national survey on the research ethics training experiences of psychology doctoral students.	little is known about the mechanisms by which psychology graduate programs transmit responsible conduct of research (rcr) values. a national sample of 968 current students and recent graduates of mission-diverse doctoral psychology programs, completed a web-based survey on their research ethics challenges, perceptions of rcr mentoring and department climate, their ability to conduct research responsibility, and whether they believed psychology as a discipline promotes scientific integrity. resea ...	23641128
sample heterogeneity and the measurement structure of the multidimensional students' life satisfaction scale.	several measurement assumptions were examined with the goal of assessing the validity of the multidimensional students' life satisfaction scale (mslss), a measure of adolescents' satisfaction with their family, friends, living environment, school, self, and general quality of life. the data were obtained via a cross-sectional survey of 8,225 adolescents in british columbia, canada. confirmatory factor and factor mixture analyses of ordinal data were used to examine the measurement assumptions. t ...	27867252
examining the theory of planned behavior applied to condom use: the effect-indicator vs. causal-indicator models.	the authors investigated whether a causal-indicator model or an effect-indicator model of the theory of planned behavior (tpb) is more suitable for predicting behavioral intention and for which behaviors. no previous studies have evaluated this question using the same sample and same behavior. in this study, african american adolescents ages 12-17 participating in risk reduction classes were assessed on their initial attitudes, norms, perceived control, and intention regarding condom use. second ...	19949867
current approach to the diagnosis and treatment of femoral-popliteal arterial disease. a systematic review.	peripheral arterial disease (pad) is a common manifestation of atherosclerosis affecting 5 million adults in the united states, with an age-adjusted prevalence of 4% to 15% and increasing up to 30% with age and the presence of cardiovascular risk factors. in this article we focus on lower extremity pad and specifically on the superficial femoral and proximal popliteal artery (sfpa), which are the most common anatomic locations of lower extremity atherosclerosis. we summarize current evidence and ...	21037847
refinements in the hierarchical structure of externalizing psychiatric disorders: patterns of lifetime liability from mid-adolescence through early adulthood.	research on hierarchical modeling of psychopathology has frequently identified 2 higher order latent factors, internalizing and externalizing. when based on the comorbidity of psychiatric diagnoses, the externalizing domain has usually been modeled as a single latent factor. multivariate studies of externalizing symptom features, however, suggest multidimensionality. to address this apparent contradiction, confirmatory factor analytic methods and information-theoretic criteria were used to evalu ...	19899840
a validation of the inventory of callous-unemotional traits in a community sample of young adult males.	callous-unemotional (cu) traits have been shown to delineate a subgroup of individuals at high risk for exhibiting severe and persistent criminal behavior. the inventory of callous-unemotional traits (icu; frick 2004) was recently developed as a comprehensive rating scale designed to measure multiple facets of cu traits. however, validation of this measure has been limited to youth in adolescence and emerging adulthood (age range=12-20), leaving questions about the utility of this measure in ear ...	24357894
antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases mkk-3 or mkk-6.	inhibitors of p38 demonstrate limited benefit in rheumatoid arthritis (ra), perhaps due to the antiinflammatory functions of p38α. this study was performed to determine if selective deletion of p38α in macrophages affects the severity of arthritis and whether blocking upstream kinases in the p38 pathway, such as mkk-3 or mkk-6, avoids some of the limitations of p38 blockade.	22488549
transtheoretical model constructs for physical activity behavior are invariant across time among ethnically diverse adults in hawaii.	objectives: physical activity (pa) research applying the transtheoretical model (ttm) to examine group differences and/or change over time requires preliminary evidence of factorial validity and invariance. the current study examined the factorial validity and longitudinal invariance of ttm constructs recently revised for pa. method: participants from an ethnically diverse sample in hawaii (n=700) completed questionnaires capturing each ttm construct. results: factorial validity was confirmed fo ...	22778669
adolescent precursors of pathways from school to work.	longitudinal data from the youth development study is used to examine: (1) how young people establish work with self-identified career potential and how these patterns are linked to educational attainments; and (2) how adolescent achievement orientations, experiences in school and work, and sociodemographic background distinguish youth who establish themselves in careers and those who flounder during this transition. multilevel latent class models reveal four school-to-work pathways from ages 18 ...	24791132
initial experience with angioseal™: safety and efficacy of the endovascular closure device.	vascular access site management is crucial to safe, efficient, and comfortable diagnostic or interventional percutaneous procedures. the angioseal™ vascular closure device has been shown to be safe and effective in reducing the time to hemostasis following angiographic or interventional procedures. relatively few studies have been conducted in the uk to assess the safety and efficacy of the device in a local setting.	24082477
evaluation of anti-inflammatory potential of the multidrug herbomineral formulation in male wistar rats against rheumatoid arthritis.	immunological and inflammatory mechanisms, which may play a role in a number of disorders like rheumatoid arthritis (ra). ancient ayurvedic physicians had developed certain dietary and therapeutic measures to arrest or prevent these disorders.	23930040
anti-arthritic activity of root bark of oroxylum indicum (l.) vent against adjuvant-induced arthritis.	oroxylum indicum (bignoniaceae) also known as sonapatha is an indigenous medicinal plant widely used in ayurvedic medicine for over thousands of years. it is an active ingredient of well-known ayurvedic formulations such as chyawanprash and dasamula. root bark of this plant has tonic and astringent properties and it is also used in rheumatism.	23798888
interleukin-22 reduces the severity of collagen-induced arthritis in association with increased levels of interleukin-10.	the mechanism of action of interleukin- 22 (il-22) in inflammatory arthritis remains unknown. il-22-deficient mice exhibit an intact humoral and cellular immune response to collagen and yet have a reduced incidence of collagen-induced arthritis (cia). further, administration of anti-il-22 does not reduce the severity of clinical arthritis but rather improves only certain aspects of joint inflammation as assessed histologically. this study was undertaken to investigate the mechanism of action and ...	23334981