Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| identification and characterization of a varicella-zoster virus dna-binding protein by using antisera directed against a predicted synthetic oligopeptide. | we have identified, in varicella-zoster virus (vzv)-infected cells, the product of the gene predicted to code for the vzv analog of the herpes simplex virus major dna-binding protein. the open reading frame of the vzv gene has the potential to code for a protein with a predicted molecular weight of 132,000 (a 132k protein). to detect the protein, a 12-amino-acid oligopeptide corresponding to the carboxyl terminus of the putative open reading frame was synthesized and used to prepare antisera in ... | 1988 | 2828675 |
| the risk of zoster after varicella vaccination in children with leukemia. | we examined the incidence of zoster in 346 children with underlying acute lymphoblastic leukemia who were immunized with live attenuated varicella vaccine while in remission. we also compared a subset of 84 of these children with a matched group of 84 children with leukemia who had had natural infection with varicella. of the 346 vaccinated children, 5 (1.45 percent) became infected with zoster after 10,878 months of observation, for an incidence of 0.552 case per 100 person-years. among the mat ... | 1988 | 2828948 |
| [minor symptoms in family practice: herpes labialis]. | 1988 | 2829037 | |
| nih conference. varicella-zoster virus infections. biology, natural history, treatment, and prevention. | during the last 10 years, there have been major advances in the understanding of varicella-zoster virus and the diseases it causes. the molecular biology of the virus is being unraveled with the aid of new molecular technologies. varicella, usually a benign manifestation of primary infection, and zoster, a result of reactivation of latent virus, can cause considerable morbidity in patients with immune impairment. antiviral drugs, especially acyclovir, ameliorate severe infections but still have ... | 1988 | 2829675 |
| history, pharmacokinetics, and pharmacology of acyclovir. | a screening program for antiviral drugs begun at burroughs wellcome in the 1960s resulted in the discovery of acyclovir in 1974. preclinical investigation brought the drug to clinical trials in 1977 and the first form of the drug (topical) was available to physicians in 1982. activity of acyclovir is greatest against herpes 1 and herpes 2, less against varicella zoster, still less against epstein-barr, and very little against cytomegalovirus. acyclovir is an antiviral agent only after it is phos ... | 1988 | 2828440 |
| nosocomial varicella: worth preventing, but how? | 1988 | 2827533 | |
| synthesis and antiviral properties of (e)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds. | treatment of 3',5'-di-o-acetyl-(e)-5-(2-bromovinyl)-2'-deoxyuridine (2) with p-chlorophenyl phosphorodichloridate and 1,2,4-triazole gave 1-(3,5-di-o-acetyl-2-deoxy-beta-d-erythro-pentofuranosyl)-(e)-5-(2-br o movinyl)- 4-(1,2,4-triazol-1-yl)pyrimidin-2(1h)-one (3). reaction of 3 with ammonia gave (e)-5-(2-bromovinyl)-2'-deoxycytidine (1), the overall yield from 2 being 60%. a similar 4-(1,2,4-triazol-1-yl) derivative (4) was obtained from 3',5'-di-o-acetyl-thymidine by the use of phosphoryl chl ... | 1988 | 2826786 |
| structures of herpes simplex virus type 1 genes required for replication of virus dna. | recently, a method has been developed to identify regions in the genome of herpes simplex virus type 1 (hsv-1) which contain genes required for dna synthesis from an hsv-1 origin of dna replication, and seven genomic loci have been identified as representing the necessary and sufficient gene set for such replication (c. a. wu, n. j. nelson, d. j. mcgeoch, and m. d. challberg, j. virol. 62:435-443, 1988). two of the loci represent the well-known genes for dna polymerase and major dna-binding prot ... | 1988 | 2826807 |
| promising new antiviral drugs. | we now have a basis for a more rational approach to rapid evaluation and development of antiviral drugs by screening for activity in vitro, testing for toxicity and efficacy in animals, and clinical testing in humans. acyclovir is a prototype of this improved process. interferon has a beneficial effect against cmv infection in renal transplant patients and has promising results in the treatment of papillomas and rhinovirus infections. it does not seem to be as effective against genital herpes or ... | 1988 | 2448352 |
| new diagnostic tests for herpes simplex and varicella zoster infections. | laboratory tests for herpetic infections can be divided into (1) morphologic, (2) immunomorphologic, (3) serologic, and (4) virologic. tzanck smears are easy to do, inexpensive, and compare favorably with cultures and immunofluorescence tests for specificity and sensitivity, but they require considerable experience to interpret accurately and they cannot differentiate between herpes type 1, herpes type 2, and varicella zoster infections. biopsies are useful when clues to a diagnosis are being so ... | 1988 | 2448353 |
| lysis of cd3 hybridoma targets by cloned human cd4 lymphocytes. | ucht1, a cd3-producing hybridoma, is lysed by cloned human t cells of both cd4 and cd8 phenotypes. the lysis is specific for the cd3 receptor and is mediated by 90% or more of all t cells from blood, without evidence for a subset of cd4 t cells incapable of cytotoxicity. cd4 clones characterized as 'helper' cells by in vitro help for specific antibody production by b cells also lysed cd3 targets. varicella zoster virus (vzv) super-infected b lymphoblasts were lysed by three of six vzv-specific t ... | 1988 | 2454888 |
| recognition of similar epitopes on varicella-zoster virus gpi and gpiv by monoclonal antibodies. | two monoclonal antibodies, mab43.2 and mab79.0, prepared against varicella-zoster virus (vzv) proteins were selected to analyze vzv gpiv and gpi, respectively. mab43.2 reacted only with cytoplasmic antigens, whereas mab79.0 recognized both cytoplasmic and membrane antigens in vzv-infected cells. immunoprecipitation of in vitro translation products with mab43.2 revealed only proteins encoded by the gpiv gene, whereas mab79.0 precipitated proteins encoded by the gpiv and gpi genes. pulse-chase ana ... | 1988 | 2455814 |
| characterization of an equine herpesvirus type 1 gene encoding a glycoprotein (gp13) with homology to herpes simplex virus glycoprotein c. | the molecular structure of the equine herpesvirus type 1 (ehv-1) gene encoding glycoprotein 13 (gp13) was analyzed. the gene is contained within a 1.8-kilobase acci-ecori restriction fragment mapping at map coordinates 0.136 to 0.148 in the ul region of the ehv-1 genome and is transcribed from right to left. determination of the nucleotide sequence of the dna fragment revealed a complete transcriptional unit composed of typical regulatory promoter elements upstream to a long open reading frame ( ... | 1988 | 2455821 |
| epitope-mapping on the epstein-barr virus major capsid protein using systematic synthesis of overlapping oligopeptides. | systematic solid-phase synthesis of all possible overlapping nonapeptides of the 1381 amino acid sequence of the epstein-barr virus major capsid protein (ebv-mcp) was used to identify the position of linear antigen epitopes on this protein as recognised by human polyclonal antisera. antisera were selected for reactivity with ebv-mcp on immunoblots. the results show that antibodies from different individual donors may recognise ebv-mcp through binding to a variety of different epitopes. these epi ... | 1988 | 2460480 |
| rapid enzyme-linked immunosorbent assay for detecting antibody to varicella-zoster virus. | 1988 | 2826610 | |
| acyclovir prevents dissemination of varicella in immunocompromised children. | fifty immunocompromised children with varicella who exhibited no signs of dissemination were treated with intravenous acyclovir or placebo in a double-blind, randomized study. twelve of 25 placebo recipients were withdrawn from treatment because of their deteriorating condition and were given open acyclovir therapy; only one of 25 recipients of acyclovir was similarly withdrawn (p less than .001). among those patients who did not receive open treatment, acyclovir significantly reduced time to fu ... | 1988 | 2826611 |
| restriction endonuclease analysis of viral dna from a patient with bilateral herpes zoster lesions. | 1988 | 2826618 | |
| impact and costs of varicella prevention in a university hospital. | information regarding all patient and staff exposures to varicella-zoster virus (vzv) was prospectively accumulated from 1/1/86 to 12/31/86 at north carolina memorial hospital. during this period of time 37 sources of exposure to vzv were reported: 10 outside and 27 within the hospital. index cases for nosocomial exposure included: 12 patients with zoster, 9 patients with varicella, two staff with varicella, three visitors with varicella, and one staff with zoster. one hundred and twenty patient ... | 1988 | 3337300 |
| varicella-zoster virus leukoencephalitis and cerebral vasculopathy. | two patients with varicella-zoster virus leukoencephalitis and acquired immunodeficiency syndrome are described. neither patient had cutaneous or disseminated varicella-zoster virus infection within the last six months of life. demyelinated lesions resembling those of progressive multifocal leukoencephalopathy were seen in their brains at autopsy. numerous cells with cowdry type a intranuclear inclusions surrounded the lesions; these cells stained positively for varicella-zoster virus with immun ... | 1988 | 3337629 |
| antiviral treatment in chickenpox and herpes zoster. | intravenous acyclovir is effective for varicella in adults and immunocompromised children, causing more rapid resolution of the illness and fewer complications. intravenous acyclovir in immunocompromised patients with herpes zoster decreases new lesion formation, decreases acute pain, halts dissemination of the virus, and lessens visceral complications. intravenous acyclovir may also be effective in zoster encephalitis. intravenous vidarabine also has a favorable affect on chickenpox and herpes ... | 1988 | 3339143 |
| comments on vaccines, august 1987. | because of latency and infectious recurrences, eradication of herpes simplex and herpes zoster from the world by vaccines is likely to be much more difficult to accomplish than eradication of smallpox. for some time we may have to settle for control of these diseases rather than their eradication. the live, attenuated varicella vaccine protects immunocompromised and normal persons against clinical chickenpox but it does not completely prevent subsequent infection with natural chickenpox virus or ... | 1988 | 3339145 |
| fatal varicella in steroid-dependent asthma. | disseminated varicella infection is a potentially life-threatening complication of chronic high-dose corticosteroid (cs) or immunosuppressive therapy. a review of the literature indicates that, with one possible exception, this complication has not occurred in a cs-dependent subject with asthma. we present in this article the clinical features and autopsy findings of a steroid-dependent subject with asthma who died of acute, disseminated varicella. a 16-year-old poorly compliant, steroid-depende ... | 1988 | 3339190 |
| [varicella zoster virus infection of the central nervous system with symptoms resembling cardiac phobia and schizophrenia]. | 1988 | 3362259 | |
| varicella-zoster virus infection. | 1988 | 3369785 | |
| unusual varicella zoster virus infection in patients with the acquired immunodeficiency syndrome. | 1988 | 3389843 | |
| cyclopentenylcytosine. a carbocyclic nucleoside with antitumor and antiviral properties. | cyclopentenylcytosine (cpe-c, 2), a pyrimidine analogue of the fermentation derived carbocyclic nucleoside neplanocin a, has been synthesized from the optically active cyclopentenylamine 3b by two synthetic routes. cpe-c demonstrates significant antitumor activity against both the sensitive and ara-c resistant lines of l1210 leukemia in vivo. multiple long term survivors are produced in both tumor models. the compound also gives 100% growth inhibition of the solid human a549 lung and mx-1 mammar ... | 1988 | 3411597 |
| acute retinal necrosis syndrome following chickenpox in pregnant woman. | a pregnant woman presented with acute retinal necrosis syndrome (arns) involving both eyes. she had had varicella eruption one month before the onset of the disease. antibody titer to the varicella-zoster virus was elevated in the aqueous humor of both eyes. to our knowledge, this is the first report which showed apparent association of varicella eruption with arns caused by varicella-zoster virus. | 1988 | 3411815 |
| varicella zoster virus infections in immunocompromised hosts. a review of the natural history and management. | varicella is relatively mild in otherwise normal children, in whom new lesions form for a mean of four days after onset and heal 50 percent of their lesions in eight days. new lesions form in most immunocompromised children for longer than five days and those not treated with antiviral drugs have a 28 percent incidence of pneumonitis and a 7 percent mortality rate. untreated immunocompromised adults with herpes zoster shed virus for longer (7.0 days) than otherwise normal adults (5.3 days). herp ... | 1988 | 3044096 |
| treatment of chickenpox in immunocompromised children. | in hungary since 1981, 98 immunocompromised children have been treated with intravenous acyclovir for varicella zoster virus infections. they were treated in an open study or a double-blind study. results of both are discussed briefly. overall, five of 74 patients with varicella died, whereas all 24 patients with herpes zoster recovered. treatment failures occurred in patients in whom treatment started late and in those with severe lymphocytopenia. in some children, varicella zoster virus-specif ... | 1988 | 3044101 |
| current therapy of varicella zoster virus infection in immunocompromised patients. a comparison of acyclovir and vidarabine. | both acyclovir and vidarabine are effective treatment for varicella zoster virus (vzv) infection in immunosuppressed patients. to determine which is preferable, therapy with these two agents was compared in a prospective, randomized trial. a total of 22 immunocompromised patients undergoing treatment for hematologic malignancies and presenting with vzv infection within 72 hours of the onset of rash were randomly assigned to receive intravenous acyclovir or vidarabine; 11 patients were randomly a ... | 1988 | 3044102 |
| managing fungal and viral infection in the immunocompromised host. | the increasing number of opportunistic fungal infections in neutropenic cancer patients has become of major concern. postmortem examinations have shown that more than half of the deaths attributed to infection were due to disseminated fungal infections. candida species are the major pathogens. unfortunately, the early diagnosis of serious fungal invasion is exceedingly difficult in these patients, since the manifestations of infection are ill-defined and the organisms can only rarely be isolated ... | 1988 | 3051213 |
| chronic herpes simplex virus and varicella zoster virus infection. | after defining such terms as persistent and chronic infection, latency, recurrence, recrudescence, and exogenous reinfection they are applied to infections with hsv and vzv. possible factors determining pathogenicity are discussed, and an overview is given of the wide range of illnesses and case reports ascribed to hsv and vzv infections. various types of infection afford different diagnostic procedures. besides virus isolation supplemented by viral antigen identification igg antibody tests (inc ... | 1988 | 3053746 |
| viral antibodies in normal tears. | viruses are a common cause of eye infection. the local mucosal response, with production of antibodies released into tears, is believed to provide an important immune defense against these agents. however very little information exists on the viral specificity of normal tear immunoglobulins. in this study we obtained tears, parotid saliva and serum from 40 normal subjects without eye disease. samples were examined by enzyme linked immunosorbent assay (elisa) for antibodies to seven common viruse ... | 1988 | 3170127 |
| continuous varicella-zoster infection associated with acyclovir resistance in a child with aids. | acyclovir has become the treatment of choice for varicella-zoster virus (vzv) infections in immunocompromised individuals. this article describes a 4-year-old girl congenitally infected with human immunodeficiency virus who developed a continuous cutaneous infection with vzv that persisted over a 14-month period until her death. initial episodes of varicella and zoster were responsive to acyclovir treatment; however, subsequent recurrences necessitated administration of multiple courses of acycl ... | 1988 | 3184352 |
| specific igg subclass reactivity in herpes simplex encephalitis. | serum and cerebrospinal fluid (csf) samples from 19 patients with a previous diagnosis of herpes simplex virus encephalitis (hsve), from 14 patients with a previous diagnosis of non hsve encephalitis and from 21 healthy subjects were examined to detect igg subclasses 1-4 reactive with herpes simplex virus (hsv), cytomegalovirus (cmv) and varicella zoster virus (vzv). antibodies to hsv were detected in csf and serum from the 14 hsve-patients with a reactivated hsv infection and from 3 of the 5 pa ... | 1988 | 3221245 |
| [virus diseases of the nervous system in selected patients at a neurologic specialty unit during a 9-year period]. | during a 9-year period an unselected population of 377 patients with clinically suspected viral diseases of the nervous system were hospitalized. due to the serological findings a definite viral etiology could be established in 123 (33%). with respect to clinical syndromes serological evidence of viral etiology was found in 74% of mono- respectively oligoneuritides, 43% of meningoencephalitides, whereas in polyneuritis only in 18%. concerning different virus strains varicella zoster virus appear ... | 1988 | 3222963 |
| varicella-zoster virus infection in chronic granulomatous disease. | 1988 | 3231504 | |
| successful combination therapy with acyclovir and vidarabine for disseminated varicella zoster virus infection with retinal involvement in a patient with b-cell lymphoma and adult t-cell leukemia. | 1988 | 3264113 | |
| herpes zoster in children with acute lymphocytic leukemia. | herpes zoster (hz) occurred in 25% (28/88) of a population of children with acute lymphocytic leukemia (all) who were seropositive for varicella zoster virus antibody before its onset; 16.5% (33/199) of the total group of children with all developed hz. there were no deaths and only one significant complication, cutaneous disseminated disease, as a result of hz. the small number of patients studied may have accounted for the failure to find a significant association between the occurrence of hz ... | 1988 | 3277389 |
| human immunodeficiency virus infection of the brain. ii. detection of intrathecally synthesized antibodies by enzyme linked immunosorbent assay and imprint immunofixation. | sera and csf from 29 patients in early and late stages of hiv infection were analysed for intrathecal antibody production. elevated csf-igg indices indicating intrathecal igg synthesis were demonstrated in 9 patients while 4 of 18 patients tested had oligoclonal igg bands in the csf. analysis of hiv-specific antibodies by enzyme-linked immunosorbent assay (whole antigen and site-directed elisa) and calculation of "antibody indices" (csf/serum antibody quotient divided by csf/serum albumin quotie ... | 1988 | 3142965 |
| sequestration of virus-specific t cells in the cerebrospinal fluid of a patient with varicella zoster viral meningoencephalitis. | the frequency of virus-specific t cells in the cerebrospinal fluid of a patient with viral infection of the brain and meninges was determined by using a single-t-cell cloning technique where a representative sampling of t cells was cloned from the cerebrospinal fluid of a patient with varicella zoster viral (vzv) meningoencephalitis. that the derived t-cell clones were in fact clonal was shown by demonstrating, on southern blot analyses, unique rearrangements of the t-cell antigen-receptor beta- ... | 1989 | 2465314 |
| interferon and interferon inhibitor levels in patients infected with varicella-zoster virus, acquired immunodeficiency syndrome, acquired immunodeficiency syndrome-related complex, or kaposi's sarcoma, and in normal individuals. | previous studies had reported that normal individuals do not have measurable levels of interferons in their circulation, whereas high levels have been found in patients in the early stages of aids (acquired immunodeficiency syndrome) and in those with aids-related complex (arc). this study was undertaken to compare levels of interferon and interferon inhibitors in plasma samples from patients with aids, arc, kaposi's sarcoma, or varicella-zoster virus infection, and from control subjects. | 1989 | 2478016 |
| existence of similar antigenic-sites on varicella-zoster virus gpi and gpiv. | we previously identified the antibody-binding site of a monoclonal antibody (mab 79.0) on varicella-zoster virus (vzv) glycoprotein i (gpi) and showed that this monoclonal antibody binds to both vzv gpi and gpiv (vafai et al., j. virol. 62, 2544, 1988). in this study, a synthetic peptide comprising the mab 79.0 binding site (designated el) was prepared and anti-peptide antibodies (ranti-el) were raised in rabbit. ranti-el recognized the primary translation products encoded by vzv genes 67 (gpiv) ... | 1989 | 2479191 |
| herpesviruses: manifestations and transmission. | 1989 | 2481002 | |
| phenotype, cytotoxic, and helper functions of t cells from varicella zoster virus stimulated cultures of human lymphocytes. | blood mononuclear cells (mnc) were stimulated with vzv in the form of live cell-associated virus, glutaraldehyde-fixed vzv-infected fibroblasts or an extracted vzv antigen. after 7 days of culture with live virus, il2 receptors (il2r) were found on cd4 and cd8 cells while cultures stimulated with fixed or extracted antigen had il2r only on cd4 cells. clones derived by limiting dilution from these cultures were tested for specificity by cytotoxicity to autologous vzv-superinfected b lymphoblasts, ... | 1989 | 2483504 |
| [results of acyclovir treatment of chickenpox and herpes zoster in children with immune tolerance]. | acyclovir was used for the treatment of varicella-zoster virus infections in 53 children (10 neonates and 43 children aged between 2 an 15 years) with immunological system deficiency hospitalized at the department of the infectious diseases of childhood in the medical academy in warszawa. the obtained results of therapy were favourable except one fatal case of the child with visceral dissemination of the virus prior to acyclovir treatment. compared with other antiviral agents used by the authors ... | 1989 | 2485894 |
| [recurrence of varicella-zoster virus infection]. | a case of varicella-zoster virus re-infection in a 3.5-year child with the acute lymphoblastic leukemia is presented. this report aims at emphasizing a possibility of re-activation of the virus in younger and younger children with immunodeficiency. a clinical course may imitate chicken-pox creating diagnostic problems. | 1989 | 2485895 |
| [lymphocytic meningitis. virologic study. analysis of the study carried out from 1984 to 1986 (632 cases)]. | the experience with the virological diagnosis of lymphocytic meningitis in the centro nacional de microbiología during 3 years (1984-1986) included 632 cases. the most common causative organism was the parotiditis virus (46.9%), particularly in children (64.6%), followed by the non-polio enteroviruses (25.3%). the varicella-zoster virus was the most common organism found in adults (33.3%). we describe some clinical and epidemiological aspects, emphasizing the absence of clinical features suggest ... | 1989 | 2490672 |
| experimental studies on the prevention and treatment of chickenpox and herpes zoster with measles vaccine. | in 151 chickenpox patients treated with live attenuated measles vaccine, the cure rate was 100%. in 145 cases of herpes zoster, the effective rate was 100% (completely cured in 91.7% and improved in 8.3%). in the treated group, the time needed for the subsidence of fever and skin rash and the duration of the disease were markedly shorter than those in the control group (p less than 0.01). it is particularly effective for alleviating pain, preventing and relieving postherpetic neuralgia in patien ... | 1989 | 2509165 |
| a lambda gt11-cdna clone specific for chronic hepatitis c generated from pooled serum presumably infected by hepatitis c virus. | a lambda gt11-random-primed-cdna clone specific for chronic hepatitis c was isolated from pooled serum presumably infected by hepatitis c virus. the translation product of the clone detect 50% of patients with chronic hepatitis c in 4 test panels but none of the patients with acute hepatitis c, other liver diseases or normal controls was positive for the peptide. the nucleotide sequence of the cdna clone, the size of which is 66 bp, has no homology to the complete sequences of known human viruse ... | 1989 | 2509279 |
| comparison of acyclovir and vidarabine in immunocompromised children with varicella-zoster virus infection. | intravenous acyclovir and vidarabine were compared in the treatment of varicella-zoster virus (vzv) infection in 25 immunocompromised children--13 with acute lymphocytic leukemia, three with other types of cancer, two with immunodeficiency and in seven undergoing prednisolone treatment. thirteen had varicella and 12 had herpes zoster. acyclovir was given intravenously to five patients with varicella and to four with herpes zoster at a dose of 5-10 mg/kg every eight hours. vidarabine was given in ... | 1989 | 2516397 |
| positively selected leu-11a (cd16+) cells require the presence of accessory cells or factors for the lysis of herpes simplex virus-infected fibroblasts but not herpes simplex virus-infected raji. | previous studies from our laboratory indicated that human nk activity against hsv-infected fibroblasts (hsv-fs) but not k562 targets was sensitive to treatment with anti-hla-dr plus c. in the current study, we have selected leu-11a+ (cd-16) cells by fluorescence activated cell sorting and found that although leu-11a enriched populations lysed k562 targets in 14-h 51cr-release assays, they were unable to kill hsv-fs targets unless a leu-11a-depleted population was added back to the effectors or u ... | 1989 | 2526183 |
| the incidence of herniated disc and varicella zoster virus infection in lumboradicular syndrome. | 121 patients suffering from lumboradicular syndrome were examined for the presence of varicella zoster virus (vzv) infection. lumbar myelography was carried out on all. vzv-antibody determination in blood, as well as in spinal fluid, was by indirect elisa. in 40% of cases lumbar myelography revealed no signs of a herniated disc; none had raised antibody titre in spinal fluid. vzv-antibody titre in blood indicated vzv infection in only 3. | 1989 | 2530747 |
| identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and epstein-barr virus. | by using amino acid sequence patterns (motifs) diagnostic of conserved regions within the catalytic domains of protein kinases, homologous open reading frames of three herpesviruses were identified as protein kinase-related genes. the three sequences, herpes simplex virus gene ul13, varicella-zoster virus gene 47, and epstein-barr virus gene bglf4, resemble serine/threonine kinases rather than tyrosine kinases. | 1989 | 2535748 |
| placebo-controlled trial of varicella vaccine given with or after measles-mumps-rubella vaccine. | a placebo-controlled study of varicella vaccine given either with or 6 weeks after measles-mumps-rubella (mmr) vaccine was undertaken in healthy children (mean age 16 months). a total of 101 varicella-zoster virus antibody-negative children completed the study. serologic response to mmr vaccine was excellent (nearly 100%) and not significantly affected by the administration of varicella vaccine. seroconversion in response to varicella vaccine was excellent and was not affected by mmr vaccine. no ... | 1989 | 2535873 |
| t lymphocyte cytotoxicity with natural varicella-zoster virus infection and after immunization with live attenuated varicella vaccine. | varicella-zoster virus (vzv) specific cytotoxicity was investigated during acute primary vzv infection, in naturally immune subjects and after vaccination with the live attenuated varicella vaccine by using t cell cultures (tcc) generated by stimulating pbmc with vzv ag and autologous vzv-superinfected lymphoblastoid cell lines as targets. lysis of vzv-infected lymphoblastoid cell lines was observed by tcc from acutely infected subjects, naturally immune subjects, and recipients of the varicella ... | 1989 | 2536059 |
| rapid diagnosis of varicella-zoster virus infection with a monoclonal antibody based direct immunofluorescence technique. | diagnosis of varicella-zoster virus (vzv) infection in immunocompromised patients is difficult because of the frequent atypical appearance. accurate and early diagnosis is important to allow rapid commencement of antiviral chemotherapy, with consequent improvement in antiviral efficacy. a monoclonal based direct immunofluorescence antibody technique (vzv ifa) was assessed in parallel with viral culture in 56 patients with suspected vzv infection. a subgroup of 17 patients from this group with cl ... | 1989 | 2536379 |
| varicella in pediatric orthotopic liver transplant recipients. | from may 1981 to may 1984, 90 pediatric patients underwent liver transplantation and 65 patients survived as of may 1986. two of the nonsurvivors died with complications related to clinical varicella. of these 67 patients (65 survivors and two nonsurvivors who died of varicella-related causes), 51 patients were determined to be varicella susceptible. clinical disease developed in no patients with serologic evidence or clinical history of varicella prior to transplantation. eighteen susceptible p ... | 1989 | 2536479 |
| transsynaptic spread of varicella zoster virus through the visual system: a mechanism of viral dissemination in the central nervous system. | we report a patient with pathologic evidence of anterograde spread of varicella zoster virus (vzv) through the visual system. a 29-year-old homosexual man developed the acquired immunodeficiency syndrome (aids) 2 months before the onset of left herpes zoster ophthalmicus. during the next 11 months, the zoster infection progressed to involve the left eye, with resultant keratitis, iritis, retinitis, and eventual blindness. later, the patient developed bilateral blindness, left hemiparesis, and fa ... | 1989 | 2536632 |
| enhancement of simian varicella virus infection in african green monkeys by recombinant human tumor necrosis factor alpha. | 1989 | 2536783 | |
| western blot analysis poorly detects antibody to gpiii of varicella-zoster virus. | 1989 | 2536785 | |
| igm and igg responses to varicella-zoster virus p32/p36 complex after chickenpox and zoster, congenital and subclinical infections, and vaccination. | varicella-zoster virus (vzv) directs the synthesis of a nonglycosylated polypeptide complex with two prominent species with relative molecular masses of 32,000 and 36,000; the p32/p36 complex is present in both the viral nucleocapsid and the nuclear matrix of the infected cell. we have now further characterized the humoral immune response of vzv-infected humans to this complex and established that it is a major viral antigen. antibodies to vzv p32/p36 were detected in sera from patients with bot ... | 1989 | 2536788 |
| identification of the major capsid protein gene of human cytomegalovirus. | the coding region for the major capsid protein (mcp) of human cytomegalovirus (hcmv) was identified by comparing the protein sequence with the respective sequences of herpes simplex virus (hsv), epstein-barr virus, and varicella-zoster virus. the predicted length of the hcmv mcp was 1,370 amino acids. comparison of the mcp sequences of the different human herpesviruses showed a homology of 25% to the mcp of hsv type 1, a homology of 29% to the mcp of epstein-barr virus, and a homology of 23% to ... | 1989 | 2536837 |
| 2-acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (a1110u), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir. | 2-acetylpyridine 5-[(dimethylamino)thiocarbonyl]thiocarbonohydrazone (a1110u) was found to be a potent inactivator of the ribonucleotide reductases (ec 1.17.4.1) encoded by herpes simplex virus types 1 and 2 and by varicella-zoster virus and to be a weaker inactivator of human ribonucleotide reductase. it also markedly potentiated the antiherpetic activity of acyclovir against these viruses in tissue culture. a1110u both decreased the dgtp pool that builds up when infected cells are treated with ... | 1989 | 2536930 |
| varicella-zoster virus infections in pregnancy. | varicella-zoster virus can cause a distinct congenital syndrome, a potentially fatal neonatal infection and life-threatening maternal illness. physicians can reduce morbidity from these conditions by advising nonimmune pregnant women to avoid exposure to chickenpox and herpes zoster and, when indicated, by promptly administering varicella-zoster immune globulin. when prevention fails, acyclovir may be effective therapy. | 1989 | 2537001 |
| giant cell pneumonia caused by varicella zoster virus in a neonate. | a premature male neonate, born at the 25th gestational week, developed pneumonia six days after delivery and died. postmortem examination of the lungs revealed giant cell pneumonia with intranuclear inclusion bodies; varicella zoster infection was confirmed by immunoperoxidase stain using monoclonal antibody to varicella zoster virus and electron microscopic examination. in previously reported necropsy cases of numerous giant-cell formation in the lung is not mentioned. therefore, the unusual fe ... | 1989 | 2537070 |
| management of varicella exposure in a neonatal intensive care unit. | we describe the management of an exposure to varicella in a neonatal intensive care unit. thirty-seven hospital staff members with negative histories of varicella were tested by enzyme-linked immunosorbent assay for antibody to varicella zoster; all were seropositive. none were restricted from clinical duties, were given varicella-zoster immune globulin, or developed disease. although only 1 of 38 cord serum samples from normal term infants was seronegative, 10 of 22 neonatal intensive care unit ... | 1989 | 2537441 |
| varicella zoster-associated neurologic disease without skin lesions. | we have investigated a group of cases with inflammatory neurologic disease and serologic evidence of varicella zoster virus activity without cutaneous vesicles. in agreement with experience, a case of cranial polyneuropathy with facial palsy and cases of aseptic meningitis were found. however, cases of acute polyneuropathy, myelitis, and encephalitis were also identified. thus, it seems that the spectrum of neurologic disease associated with varicella zoster virus in the absence of skin lesions ... | 1989 | 2537615 |
| titration of igg antibodies against varicella zoster virus before bone marrow transplantation is not predictive of future zoster. | serum antibodies to varicella zoster virus (vzv) were measured in 77 patients about to undergo allogeneic bone marrow transplantation, and in 65 of their donors. ten patients developed zoster within the first 6 months following transplant. there was no significant difference in the mean pretransplant antibody titre between those patients who did or did not subsequently develop zoster. likewise, the level of antibody to vzv amongst donors had no effect on the subsequent development of zoster. we ... | 1989 | 2537881 |
| susceptibility of hospital-based health care personnel to varicella-zoster virus infections. | varicella-zoster virus (vzv) transmission poses a major infection risk for health care workers in the hospital environment. immunologically normal adults who contract varicella have 9 to 25 times the risk of major morbidity or death from infection compared with healthy children. moreover, varicella infection during pregnancy is associated with a high rate of complications and the risk of the congenital varicella syndrome. to evaluate susceptibility to vzv infection among hospital workers, the em ... | 1989 | 2538095 |
| questions and controversies about varicella-zoster infections. | 1989 | 2538487 | |
| liposomal interferon-beta: sustained release treatment of simian varicella virus infection in monkeys. | liposomal formulations (distearoylphosphatidylcholine:dipalmitoylphosphatidylglycerol, 9:1) of recombinant human interferon-beta ser17 (ifn-beta), administered im to african green monkeys at doses of 10(7) units/kg on days 1 and 6 after infection with simian varicella virus, resulted in partial protection of the monkeys from viral infection. aqueous interferon administered under the same dosing regimen was ineffective. when given at 10(6) units/kg per dose twice daily for 10 d, however, it was h ... | 1989 | 2538517 |
| a method to identify distinctive charge configurations in protein sequences, with application to human herpesvirus polypeptides. | charge interactions are of great importance for protein function and structure, and for a variety of cellular and biochemical processes. we present a systematic approach to the detection of distinctive clusters, runs and periodic patterns of charged residues in a protein sequence. criteria and formulae are set forth to assess statistical significance of these charge configurations. for the 80-odd proteins potentially encoded by the epstein-barr virus, only the major nuclear antigens of the laten ... | 1989 | 2538622 |
| persistence of immunity to varicella in children with leukemia immunized with live attenuated varicella vaccine. | to determine the safety and efficacy of varicella vaccine, we studied 437 children in remission from leukemia who were immunized with live attenuated varicella virus. three hundred one of the patients received two doses of vaccine and 136 received a single dose of vaccine from 1 of 10 lots from two manufacturers. the patients have been followed for an average of three years (range, one to six). seroconversion occurred in 88 percent of the 437 children after the first dose of vaccine and in 98 pe ... | 1989 | 2538749 |
| the prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation. | eighty-two patients were randomly allocated to receive intravenous acyclovir 5 mg kg-1 t.d.s. for 23 days followed by oral acyclovir 800 mg 6-hourly for 6 months or matching placebos after allogeneic bone marrow transplantation. herpes simplex and varicella zoster virus infections were significantly reduced during the period of administration of acyclovir. no reduction in cytomegalovirus infection was demonstrated. the drug was not toxic. | 1989 | 2539180 |
| inhibition of varicella-zoster virus in vitro by human peripheral blood mononuclear cells. | a functional in vitro assay of cell-mediated immunity to varicella-zoster virus (vzv) is described. this procedure uses an enzyme-linked immunosorbent assay (elisa) to measure the inhibitory effect of human peripheral blood mononuclear cells on vzv antigen production by vzv-infected cell monolayers. when mononuclear cells from vzv-immune, tetanus-immune donors were stimulated with either vzv antigen or tetanus toxoid they reduced vzv antigen production. in contrast, mononuclear cells from vzv-no ... | 1989 | 2539281 |
| physical mapping and nucleotide sequence of a herpes simplex virus type 1 gene required for capsid assembly. | in this report, we describe some phenotypic properties of a temperature-sensitive mutant of herpes simplex type 1 (hsv-1) and present data concerning the physical location and nucleotide sequence of the genomic region harboring the mutation. the effect of shifts from the permissive to the nonpermissive temperature on infectious virus production by the mutant a44ts2 indicated that the mutated function is necessary throughout, or late in, the growth cycle. at the nonpermissive temperature, no majo ... | 1989 | 2539510 |
| investigation of varicella-zoster virus infection of lymphocytes by in situ hybridization. | peripheral blood mononuclear cells harboring viral gene sequences were detected during primary varicella-zoster virus (vzv) infection of the human host and the strain 2 guinea pig by in situ hybridization with a 3h-labeled vzv dna probe. activated t lymphocytes were permissive for vzv infection at low frequency in vitro. | 1989 | 2539528 |
| zoster in normal children after varicella vaccine. | 1989 | 2540244 | |
| are current therapies useful for the prevention of postherpetic neuralgia? a critical analysis of the literature. | to determine whether current therapies are useful in preventing postherpetic neuralgia (phn) by analysis of study designs and pooled results. | 1989 | 2540301 |
| [acute necrotizing retinitis following varicella zoster virus infection]. | as far as we know today, acute retinal necrosis is caused by infection with a virus of the herpes group. reports are occasionally published of retinitis developing before or after herpes zoster dermatitis. the present paper reports the case of a patient who developed a retinitis of the right eye five years after a herpes zoster infection of the ophthalmic nerve. studies and treatment of vzv retinitis and retinitis before or after zoster retinitis reported in the literature are summarized. the po ... | 1989 | 2540379 |
| [a mini epidemic of varicella zoster virus reinfection at a department of hematology]. | whereas primary infection with varicella zoster virus (vzv) (chickenpox) and reactivation of vzv (shingles) are common and recognized, clinical reinfection with vzv is rare. a little epidemic of presumed reinfection with vzv in six immune-compromised adults is presented here. the epidemic lasted for three months, during which a healthy young woman also developed a primary vzv infection in the form of chickenpox. in the immune-compromised patients, the clinical picture was dominated by disseminat ... | 1989 | 2540583 |
| screening for varicella-zoster immunity and the use of varicella zoster immune globulin in pregnancy. | 1989 | 2540653 | |
| improvement of the absorption of oral (r,s)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine, an anti-varicella-zoster virus drug, in rats and monkeys. | in an effort to improve the gastrointestinal absorption of (r,s)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine [(+/-)2hm-hbg], various salts and esters of the compound were synthesized and pharmacokinetic experiments were performed in rats and monkeys. the sodium or hydrochloride salts and short-chain esters of (+/-)2hm-hbg showed bioavailability characteristics that were equally as poor as those of (+/-)2hm-hbg. however, the esters given as salts tended to be better absorbed than the parent compo ... | 1989 | 2540706 |
| production of polyclonal antisera against cytomegalovirus and varicella-zoster virus by use of affinity-purified viral antigens. | specific animal antisera to cytomegalovirus (cmv) and varicella-zoster virus (vzv), devoid of antibodies to host cell components, have been difficult to prepare because of the cell-associated nature of these viruses. a simple method for the purification of cmv and vzv antigens is described in this paper. the viral antigens were purified from commercially available crude antigens by affinity chromatography with human antibodies against cmv and vzv. rabbits were immunized with the purified antigen ... | 1989 | 2540778 |
| a simple and sensitive assay for varicella-zoster virus. | a plaque assay procedure has been adapted for vzv which, by obviating the need of a preformed cell monolayer, shortens the assay time, and provides improved sensitivity. the size and clarity of the plaques obtained are comparable to those seen in previously-described plaque assay methods for vzv. | 1989 | 2542349 |
| definition of high-proficiency serological markers for diagnosis of varicella-zoster virus infections by enzyme immunoassay. | the levels of varicella-zoster virus (vzv)-specific igg, igm, and iga antibodies produced in 22 cases of varicella, 22 cases of cutaneous zoster, and 12 cases of acute aseptic meningitis due to vzv in the absence of cutaneous lesions, were measured by indirect enzyme immunoassay (eia) and compared with those observed in a group of 34 age-matched controls. the definition of cutoff titres for each serological marker and combinations of them allowed early diagnosis of infection in 82% of varicella ... | 1989 | 2542432 |
| rapid detection of varicella-zoster virus in clinical specimens using monoclonal antibodies on shell vials and smears. | monoclonal antibodies were used for detecting varicella-zoster virus (vzv) by immunofluorescence (if) in clinical specimens inoculated on shell vial cultures. vesicles of 74 patients with varicella or herpes zoster-like eruptions were tested by this method and by conventional cell culture. further diagnostic tests were direct if on smears (42 patients), the cytological tzanck test (28 patients), and serology (30 patients). both if assays were performed with the commercial vzv-specific monoclonal ... | 1989 | 2542440 |
| antibodies against varicella-zoster virus and herpes simplex virus deoxythymidine kinase in heterologous infections. | antibody responses to varicella-zoster virus (vzv) deoxythymidine kinase (dtk) and herpes simplex virus (hsv) dtk in homologous and heterologous infections were studied. antibodies blocking the enzymatic activity of vzv-dtk appeared late after varicella and decreased more or less in parallel with the decreasing complement fixing [cf] titre. in herpes zoster, on the other hand, antibodies to vzv-dtk appeared soon after infection. antibodies against hsv dtks appeared long after primary infection, ... | 1989 | 2542443 |
| varicella-zoster virus infection of adult rat sensory neurons in vitro. | we report here an in vitro model of neuronal infection by varicella-zoster virus (vzv). such a model has been achieved by using dissociated adult rat dorsal root ganglia cells infected by cocultivation with vzv-infected mrc5 cells or with cell-free virus. indirect vzv immunolabeling, in situ hybridization, and neuron-specific immunolabeling demonstrated that vzv infection occurred selectively in neurons. vzv-specific immunolabeling detected a few neurons 1 or 2 days postinfection but not later. ... | 1989 | 2542622 |
| [structure and functional analysis of genomes of herpesviruses: varicella-zoster virus]. | 1989 | 2542649 | |
| [dna diagnosis and epidemiologic analysis of varicella-zoster virus infection]. | 1989 | 2542653 | |
| [diagnosis of varicella-zoster virus infection by immunological method]. | 1989 | 2542657 | |
| [chemotherapy to thymidine kinase producing virus (hsv-1, hsv-2, vzv) infection]. | 1989 | 2542661 | |
| [efficacy of live varicella vaccine strain (oka) in high-risk patients]. | 1989 | 2542665 | |
| [pathogenesis of herpes zoster]. | long-term follow-up of 2000 patients with herpes zoster (hz) in the department of viral neuroinfections as well as special hz studies provided evidence for comprehensive evaluation of hz pathogenesis. in addition to peripheral nervous system involvement, hz is shown to cause systemic disorders typical for neuroviral infections. the principles of adequate pathogenetic therapy are validated. it is believed that relevant pathogenetic studies contribute to the development of general pathology. | 1989 | 2543167 |
| rapid detection of cytomegalovirus by 24-well plate centrifugation with the use of a monoclonal antibody to an early nuclear antigen. | two methods for the detection of cytomegalovirus (cmv) in 457 clinical specimens were compared: (1) centrifugal inoculation of mrc-5 cells seeded on coverslips in 24-well plates and staining with a monoclonal antibody to cmv early nuclear antigen after incubation for both 16-18 hours (ea-1) and four days (ea-4); and (2) conventional tube cell culture. cmv was identified in 50 (11%) specimens from 34 different patients. ea-1 and ea-4 had positive results for cmv in 32 (64%) and 36 (73%) of the sp ... | 1989 | 2543211 |
| nonenzymic glycation of human immunoglobulins does not impair their immunoreactivity. | diabetic patients have an increased proportion of their immunoglobulins nonenzymically glycated. to investigate the possibility that this may contribute to increased susceptibility to infection, we compared the immunoreactivity of glycated and nonglycated human immunoglobulins against rubella and hepatitis; streptococcal exoenzyme and infectious mononucleosis; human lymphocytotoxic antigens (hla); and varicella zoster in terms of antigen-antibody binding, cell agglutination, cytotoxicity, and co ... | 1989 | 2543516 |
| transient intrathecal igg synthesis in herpes zoster myelitis: 2 case reports. | alterations in cerebrospinal fluid in 2 cases of viral myelopathy associated with herpes zoster infection are reported. viral myelopathy is a rare complication of herpes zoster. quantitatively there was a slight increase in igg production and oligoclonal igg bands were detected by isoelectric focusing. these parameters returned to normal after 1 year suggesting a transient involvement of the central nervous system. | 1989 | 2543579 |
| identification and nucleotide sequence of a gene in equine herpesvirus 1 analogous to the herpes simplex virus gene encoding the major envelope glycoprotein gb. | a gene in equine herpesvirus 1 (ehv-1; equine abortion virus) equivalent to the gb glycoprotein gene of herpes simplex virus (hsv) has been identified by dna hybridization and nucleotide sequencing. a 4.3 kbp ehv-1 psti-clai sequence (0.40 to 0.43 map units) contained an open reading frame flanked by appropriate control elements and was capable of encoding a polypeptide of 980 amino acids. this had 50 to 60% identity over a 617 amino acid conserved region with the gb gene products of hsv and thr ... | 1989 | 2543744 |