Publications

[cat-scratch disease as cause of lymphadenitis colli].	cat-scratch disease as cause of lymphadenitis colli. cat-scratch disease is a frequent cause of lymphadenitis colli. it mainly affects children and adolescents younger than 21 years. since the clinical picture is not characteristic, a history of contact to cats or kittens is highly valuable for diagnosing the disease. major aspects of the disease concerning epidemiology, diagnostic procedures, clinical presentation and therapy are discussed.	2005	16358204
[inguinal mass as presentation of cat-scratch disease].		2005	16358433
comparative proteomic analysis of b. henselae houston and b. henselae marseille by two-dimensional gel electrophoresis.	to compare the protein difference between b. henselae houston and b. henselae marseille by two-dimensional gel electrophoresis.	2005	16370318
[cat-scratch disease].	to study the etiology, epidemiology, clinical and pathological features, diagnose and treatment of cat-scratch disease(csd).	2005	16375109
clinicopathologic findings in dogs seroreactive to bartonella henselae antigens.	to assess the potential clinical relevance of seroreactivity to bartonella henselae antigens in dogs.	2005	16379647
[prevalence of serum antibodies against bartonella ssp. in a health population from the south area of the seville province].	to know the prevalence of serum antibodies against bartonella spp. in a healthy population from south of spain.	2005	16381097
pattern visual evoked potentials in eyes with disc swelling due to cat scratch disease-associated neuroretinitis.	to evaluate optic nerve function by pattern visual evoked potentials (veps) in eyes with optic disc swelling due to neuroretinitis associated with cat scratch disease (csd).	2005	16328936
aortic valve endocarditis with bartonella quintana - a rare entity.	endocarditis caused by bartonella species is difficult to diagnose and still remains a rare entity. therefore, a young male patient undergoing aortic valve replacement for culture-negative endocarditis is reported in whom the diagnosis of a bartonella quintana infection was made with a great delay postoperatively.	2005	16331372
[detection of the bartonella dna by the method of nested pcr in patients after tick bites in novosibirsk region].	arthropod-borne bacterial pathogen bartonella dna was detected in human blood cells after tick bites in summer 2003 and 2004 in novosibirsk region by nested pcr with primers specific to groel gene of hsp60 protein. comparative assay of 190 p.b. of long pcr fragment revealed that the nucleotide sequences might belong to bartonella henselae and bartonella quintana.	2005	16334219
bacterial 16s ribosomal dna in house dust mite cultures.	allergen extracts prepared from dermatophagoides farinae contain significantly more endotoxin than dermatophagoides pteronyssinus extracts, and extracts from both mite extracts contain more endotoxin than pollen extracts. attempts to culture bacteria from mite cultures have failed to establish the sources of the endotoxin.	2005	16337462
disseminated cat scratch disease with vertebral osteomyelitis and epidural abscess.	a 5-year-old boy with cat scratch disease presented with fever of unknown origin and osteomyelitis of the thoracic spine and epidural abscess. he did not have localizing signs or symptoms. computed tomography of the abdomen, which was initially negative, showed hepatosplenic disease. cat scratch disease has variable systemic presentations and should be included in the differential diagnosis of fever of unknown origin if an epidemiologic risk factor is present.	2005	16351038
[multifocal chorioretinitis, papillitis, and recurrent optic neuritis in cat-scratch disease].	to evaluate the causative factor for multifocal chorioretinitis, papillitis, and recurrent optic neuritis. a 41-year-old patient presenting multifocal choroiditis, papillitis, and recurrent optic neuritis was evaluated with funduscopy, angiography (fa), optical coherence tomography (oct), visual evoked potentials (vep), and numerous blood laboratory tests. fa and oct showed multifocal pigment epithelial detachments. vep showed typical changes for optic neuritis and papillitis. indirect fluoresce ...	2005	16395190
[abrupt visual loss in children. three case studies of ocular bartonellosis].	to evaluate the severity and progression of neuroretinitis in children caused by bartonella.	2005	16395224
rodent-associated bartonella in saskatchewan, canada.	six species of wild rodents were sampled at 10 sites in 2002 and 2003 to determine the prevalence of bartonella infections in rodent communities near saskatoon, saskatchewan, canada. isolates were characterized genotypically and compared with isolates found at other locations. of 104 wild rodents examined, 57% were infected with bartonella and prevalence within species varied from 49% for richardson's ground squirrels (spermophilus richardsonii) to 90% for franklin's ground squirrels (s. frankli ...	2005	16417436
bartonellae as elegant hemotropic parasites.	bartonella species are hemotropic bacterial parasites of a wide range of mammals that occasionally cause disease in humans. the low prevalence of clinical manifestations compared to the high prevalence of infection underlines the elegance of these parasites that carefully exploit their hosts in a manner that optimizes their transmission. recent research efforts have begun to determine the strategies involved in this exploitation, and significant progress has been made in unraveling an unusually ...	2005	16481527
production of recombinant protein pap31 and its application for the diagnosis of bartonella bacilliformis infection.	tropical bartonellosis is a highly fatal epidemic and endemic infectious disease that occurs throughout the communities of the andes mountains in south america. the disease is caused by the facultative intracellular bacteria, bartonella bacilliformis. the emergence of bartonellosis in new geographic areas and an increase in the number of reported cases suggest the need for a rapid test for epidemiologic study and investigation of the disease burden. the objective of this research is to develop a ...	2005	16481528
bartonella bacilliformis groel: effect on growth of human vascular endothelial cells in infected cocultures.	bartonella are the only bacteria known to induce angioproliferative lesions of the human vasculature and liver during infection. previous work from our lab suggests that groel participates in the mitogenic response observed in huvec cultures supplemented with the soluble fraction of bartonella bacilliformis. work in this study shows that exposure to high concentrations of the fraction is actually cytotoxic for huvecs. to analyze this phenomenon, live b. bacilliformis-huvec cocultures were employ ...	2005	16481529
occurrence of bartonella henselae and bartonella quintana among human immunodeficiency virus-infected patients.	the purpose of this study was to determine the seroprevalence against bartonella henselae and bartonella quintana among a risk group, patients with hiv infection, and to identify the epidemiological factors involved. our data indicate that the prevalence of bartonella infection among hiv-infected patients is much greater than that in the healthy population of the same area and that bartonella infection should be considered in the differential diagnosis for patients with hiv disease.	2005	16481530
bacillary angiomatosis caused by bartonella quintana.	bacillary angiomatosis is a disorder of neovascular proliferation involving skin and lymph nodes of immunosuppressed patients. bartonella henselae or bartonella quintana have been inculpated as causative by direct culture or pcr amplification of dna sequences. here, we report the clinical evolution of a patient infected with human immunodeficiency virus (hiv) whose b. quintana infection was diagnosed by pcr.	2005	16481531
molecular screening of bartonella species in rodents from the russian far east.	a potentially broad-range pcr system for glta gene amplification has been designed. a nearly full (992 bp) sequence of the glta gene was amplified in two steps. dna was extracted from organs (spleen and liver) of four mostly spread species of rodents: apodemus agrarius and apodemus peninsulae mice; clethrionomys rufocanus and microtus fortis voles. all amplicons have been sequenced. the incidence of bartonella species in rodents was 73%, 60%, 60%, and 83% for the above-mentioned rodents, respect ...	2005	16481532
characterization of genes involved in long-term bacteremia in mice by bartonella birtlesii.		2005	16481533
bartonella henselae in porpoise blood.	we report detection of bartonella henselae dna in blood samples from 2 harbor porpoises (phocoena phocoena). by using real-time polymerase chain reaction, we directly amplified bartonella species dna from blood of a harbor porpoise stranded along the northern north carolina coast and from a pre-enrichment blood culture from a second harbor porpoise. the second porpoise was captured out of habitat (in a low-salinity canal along the northern north carolina coast) and relocated back into the ocean. ...	2005	16485476
bartonella quintana in cynomolgus monkey (macaca fascicularis).	we identified a bartonella quintana strain by polymerase chain reaction amplification, cloning, and sequencing of dna extracted from lysed erythrocytes and cultured colonies grown from peripheral blood collected from a captive-bred cynomolgus monkey (macaca fascicularis). this report describes naturally acquired b. quintana infection in a nonhuman primate.	2005	16485482
a review of emerging flea-borne bacterial pathogens in new zealand.	recent studies have shown that rickettsia typhi, r. felis, bartonella henselae, and b. clarridgeiae occur in new zealand. to raise awareness of these emerging and re-emerging flea-borne bacterial pathogens among new zealand health workers, we review the clinical features, diagnosis, and treatment of infections, and the biology of the major flea vectors.	2005	15682209
[cat-scratch disease].		2005	15695034
bartonella vinsonii subsp. arupensis as an agent of blood culture-negative endocarditis in a human.	we report the case of a patient hospitalized with endocarditis. the etiological diagnosis of bartonella was suggested by detection of high titers of antibodies by immunofluorescence and western blotting. two different nested pcrs performed on sera identified bartonella vinsonii subsp. arupensis by sequencing.	2005	15695714
visual loss after cat scratch.		2005	15632237
multispacer typing technique for sequence-based typing of bartonella quintana.	bartonella quintana is a worldwide fastidious bacterium of the alphaproteobacteria responsible for bacillary angiomatosis, trench fever, chronic lymphadenopathy, and culture-negative endocarditis. the recent genome sequencing of a b. quintana isolate allowed us to propose a genome-wide sequence-based typing method. to ensure sequence discrimination based on highly polymorphic areas, we amplified and sequenced 34 spacers in a large collection of b. quintana isolates. six of these exhibited polymo ...	2005	15634949
pcr detection of bacteria on cardiac valves of patients with treated bacterial endocarditis.	we used broad-range pcr amplification and sequencing to detect and identify bacterial dna in 156 valves of patients treated for infective endocarditis (ie). bacterial dna was found more frequently in patients who underwent valve replacement while on antibiotic treatment for ie (60%) than in patients who had completed antibiotic treatment for ie (37%; p = 0.02). we found specific bacterial dna in valves removed from 11 of 30 patients who had completed antibiotic treatment for ie. six had no histo ...	2005	15634966
evidence of bartonella sp. in questing adult and nymphal ixodes ricinus ticks from france and co-infection with borrelia burgdorferi sensu lato and babesia sp.	ticks are known vectors for a wide range of pathogenic microorganisms. their role in the transmission of some others is so far only suspected. ticks can transmit multiple pathogens, however, little is known about the co-existence of these pathogens within questing ticks. we looked for the presence of dna from three micro-organisms, bartonella sp., borrelia burgdorferi sensu lato and babesia sp. which are known or suspected tick-borne pathogens, using a cohort of 92 questing ixodes ricinus ticks ...	2005	15610725
bartonella henselae inhibits apoptosis in mono mac 6 cells.	bartonella henselae causes the vasculoproliferative disorders bacillary angiomatosis and peliosis probably resulting from the release of vasculoendothelial growth factor (vegf) from infected epithelial or monocytic host cells. here we demonstrate that b. henselae in addition to vegf induction was also capable of inhibiting the endogenous sucide programme of monocytic host cells. our results show that b. henselae inhibits pyrrolidine dithiocarbamate (pdtc)-induced apoptosis in mono mac 6 cells. b ...	2005	15617526
demonstration of intracellular microorganisms (rickettsia spp., chlamydia pneumoniae, bartonella spp.) in pathological human aortic valves by pcr.	rickettsiae, which causes vasculitis, has not been linked to atherosclerotic cardiovascular disease in contrast to chlamydia pneumoniae whose association with coronary artery disease and with sclerotic heart valves in patients undergoing aortic valve replacement is well established, even if causality is yet to unproven. in the search for any of these infectious agents, 84 pathological and 15 normal aortic heart valves of patients undergoing forensic autopsy were analysed by pcr and dna-sequencin ...	2005	15603840
[cotton wool spots in a 16-year-old girl].		2005	15095109
production of recombinant bartonella henselae 17-kda protein for antibody-capture enzyme-linked immunosorbent assay.	the bartonella henselae 17-kda protein was expressed in a prokaryotic expression system as a histidine-tagged fusion protein and was purified. the target gene was cloned into a recombinant expression construct, ptri-17kd. the expressed protein was purified to near homogeneity by a nickel-agarose column chromatography. protein recovery was estimated to be 2.9 mg from 100 ml of bacterial culture. the purified 17-kda protein was recognized by serum from patients infected with b. henselae and barton ...	2006	16490335
bartonella quintana characteristics and clinical management.	bartonella quintana, a pathogen that is restricted to human hosts and louse vectors, was first characterized as the agent of trench fever. the disease was described in 1915 on the basis of natural and experimental infections in soldiers. it is now recognized as a reemerging pathogen among homeless populations in cities in the united states and europe and is responsible for a wide spectrum of conditions, including chronic bacteremia, endocarditis, and bacillary angiomatosis. diagnosis is based on ...	2006	16494745
epidemiological studies on bartonella quintana infections among homeless people in tokyo, japan.	in an epidemiological investigation of trench fever in japan, we compared the seroprevalence of bartonella quintana in homeless people and in the general population. in homeless rescue outreach programs held in tokyo from may 2001 to march 2003, 151 blood samples were taken from non-hospitalized homeless people. the prevalence of igm and igg antibodies against b. quintana in these people was compared with that in 200 healthy blood donors using a commercially available indirect fluorescent antibo ...	2006	16495631
localized bacillary angiomatosis in the oral cavity: observations about a neoplasm with atypical behavior. description of a case and review of the literature.	bacillary angiomatosis is a rather frequent infectious pathology appearing mainly in the skin but can also affect the liver, spleen, heart, bones, lungs, muscles, central nervous system and other organs. the localization of the lesion in the oral cavity is rather rare, as it is evident in the literature. bacillary angiomatosis can be clinically similar to the kaposi's sarcoma and histologically confused with angiosarcoma, epitheloid hemangioma and pyogenic granuloma. a case of bacillary angiomat ...	2006	16495874
first molecular evidence of bartonella quintana in pediculus humanus capitis (phthiraptera: pediculidae), collected from nepalese children.	trench fever is a body louse-borne disease caused by bartonella quintana brenner. the recent status of louse infestation in nepalese children is not well known. we collected head and body lice, pediculus humanus capitis de geer and pediculus humanus humanus l., respectively, from 30 children, including 11 cases of double infestation with both head and body lice. detection of b. quintana in both louse species identified was carried out by polymerase chain reaction (pcr). pcr products with b. quin ...	2006	16506456
bartonella henselae bacilli detected in vitrectomy aspirates in a patient with massive vitreous opacity with total retinal detachment.	to present endophthalmitis-like massive vitreous opacity as a manifestation of cat-scratch disease.	2006	16507491
do dogs harbour risk factors for human breast cancer?	we ask consulting patients regularly whether they keep pets in order to identify zoonotic factors. it became apparent that patients with breast carcinoma (n=69) owned significantly more often dogs but not cats compared to age matched female controls. we compared the frequencies of dog and pet ownership with data from public available statistics on women (n=1320) of the same age group in bavaria. the most striking result was that more than twice the number of patients kept dogs permanently in the ...	2006	16516398
brucella outer membrane protein omp31 is a haemin-binding protein.	the expression of haemin-binding proteins (hbps) in the outer membrane is one of the strategies used by gram-negative bacteria to obtain iron from the host. no hbp has been described in brucella spp. we investigated whether omp31, an outer membrane protein from brucella with homology to hbps from bartonella quintana, is an hbp. soluble recombinant omp31 bound specifically to haemin-agarose, while an unrelated brucella protein (sura) did not. a similar experiment showed that native omp31 found in ...	2006	16517201
molecular detection of bartonella quintana, b. elizabethae, b. koehlerae, b. doshiae, b. taylorii, and rickettsia felis in rodent fleas collected in kabul, afghanistan.	the prevalences of bartonella spp. and rickettsia spp. were investigated using molecular methods in 77 rodent fleas collected in november 2002 by the french forces detachment in kabul, afghanistan. overall, bartonella dna was detected in 15.5% of gerbil fleas and 40.5% of rat fleas, whereas rickettsia felis was found in 9% of gerbil fleas. we described for the first time in this country bartonella quintana, b. koehlerae, b. taylorii, and rickettsia felis in fleas from the gerbil species meriones ...	2006	16525103
type iv secretion systems and their effectors in bacterial pathogenesis.	type iv secretion systems (t4sss) are membrane-associated transporter complexes used by various bacteria to deliver substrate molecules to a wide range of target cells. t4sss are involved in horizontal dna transfer to other bacteria and eukaryotic cells, in dna uptake from or release into the extracellular milieu, in toxin secretion and in the injection of virulence factors into eukaryotic host target cells by several mammalian pathogens. rapid progress has been made towards defining the structu ...	2006	16529981
etiology of tick-borne febrile illnesses in adult residents of north-eastern poland: report from a prospective clinical study.	febrile tick-borne diseases can be caused by different pathogens. the study objective was to prospectively determine the etiology of infection among adults exposed to tick bite and to detect acute human granulocytic anaplasmosis (hga), a recently emerging infection, in north-eastern poland. we evaluated 68 patients (34 males and 34 females, mean age 44.2+/-15 years) who had fever within 4 weeks after a tick bite. paired sera were tested for antibodies against tick-borne encephalitis virus, borre ...	2006	16530481
predominant t helper 2 immune responses against bartonella henselae in naturally infected cats.	this study was conducted to explicate the mechanism of long-term bacteremia in bartonella henselae-infected cats by the examining host immune responses. blood samples were collected from three naturally infected cats and the igg antibody titers and the cytokine responses in peripheral blood mononuclear cells (pbmc) were examined by quantitative reverse transcriptase-polymerase chain reactions (rt-pcr). relapsing bacteremia was found in two of the three cats during the examination period. the qua ...	2006	16547414
anti-francisella tularensis dna aptamers detect tularemia antigen from different subspecies by aptamer-linked immobilized sorbent assay.	aptamers are powerful candidates for molecular detection of targets due to their unique recognition properties. these affinity probes can be used to recognize and bind to their targets in the various types of assays that are currently used to detect and capture molecules of interest. they are short single-stranded (ss) oligonucleotides composed of dna or rna sequences that are selected in vitro based on their affinity and specificity for the target. using combinatorial oligonucleotide libraries, ...	2006	16550191
pet ownership in immunocompromised children--a review of the literature and survey of existing guidelines.	pet ownership has been associated with both emotional and physical health benefits. however, owning pets may also pose health risks to immunocompromised patients through zoonotic transmission of disease. our initial impression was that there is a lack of any evidence base in information given by health care professionals regarding these risks. we therefore aimed to produce evidence-based guidelines addressing this issue. a pubmed search was undertaken and a variety of literature on zoonoses revi ...	2006	16581294
co-detection of bartonella henselae, borrelia burgdorferi, and anaplasma phagocytophilum in ixodes pacificus ticks from california, usa.	presence of bartonella dna was explored in 168 questing adult ixodes pacificus ticks from santa cruz county, california. bartonella henselae type i dna was amplified from 11 ticks (6.55%); previously, two (1.19%) were found to be infected with borrelia burgdorferi and five (2.98%) with anaplasma phagocytophilum. detection of b. henselae was not dependent on co-infection. the present study offers additional evidence that ixodes spp. ticks may act as hosts and possibly vectors for b. henselae.	2006	16584332
molecular detection of microbes in nasal tissue of dogs with idiopathic lymphoplasmacytic rhinitis.	lymphoplasmacytic rhinitis (lpr) is a common histologic finding in dogs with chronic nasal disease; however, potential etiologies of this disorder have not been examined. we investigated the hypothesis that specific microbes contribute to clinical disease in dogs with lpr. paraffin-embedded nasal biopsies were obtained from 19 dogs with lpr, 10 dogs with nasal neoplasia, and 10 dogs with nasal aspergillosis. nucleic acids were extracted from paraffin blocks, and real-time quantitative polymerase ...	2006	16594580
rickettsial agents from parasitic dermanyssoidea (acari: mesostigmata).	mites are often overlooked as vectors of pathogens, but have been shown to harbor and transmit rickettsial agents such as rickettsia akari and orientia tsutsugamushi. we screened dna extracts from 27 mites representing 25 species of dermanyssoids for rickettsial agents such as anaplasma, bartonella, rickettsia, and wolbachia by pcr amplification and sequencing. dna from anaplasma spp., a novel bartonella sp., spiroplasma sp., wolbachia sp., and an unclassified rickettsiales were detected in mite ...	2006	16596351
kikuchi's disease or kikuchi's syndrome?		2006	16421809
transient monoclonal gammopathy in a patient with bartonella quintana endocarditis.	monoclonal gammopathy has been reported rarely in association with infectious diseases. viral infection has been the most frequently reported. we report a case of bartonella quintana endocarditis in a 45-year-old homeless male associated with a monoclonal igg kappa gammopathy. the gammopathy disappeared after 8 months of antibiotics while the bartonella antibody titre was decreasing. this correlation suggests a causative role for b. quintana for the monoclonal gammopathy. to the best of our know ...	2006	16432867
serological survey of vector-borne zoonotic pathogens in pet cats and cats from animal shelters and feral colonies.	although cats and their arthropod parasites can sometimes be important sources of zoonotic diseases in humans, the extent of exposure among various cat populations to many potential zoonotic agents remains incompletely described. in this study, 170 domestic cats living in private homes, feral cat colonies, and animal shelters from california and wisconsin were evaluated by serology to determine the levels of exposure to a group of zoonotic vector-borne pathogens. serological positive test result ...	2006	16434226
confirmation of diagnosis of cat scratch disease by immunohistochemistry.		2006	16434905
[diagnostic imaging (257). a boy with a swollen inguinal gland].	in a 4-year-old boy with left-sided inguinal lymphadenopathy and a papule on his left lower leg situated at the end of a scar of a probable cat scratch, cat scratch disease was confirmed serologically.	2006	16440563
prevalence of selected infectious disease agents in cats from arizona.	the objective of this study was to use polymerase chain reaction (pcr) assays to determine the prevalence of ehrlichia species, anaplasma phagocytophilum, mycoplasma haemofelis, 'candidatus mycoplasma haemominutum' and bartonella species from feral and relinquished cats in phoenix and nogales, arizona. dna from one or more of the organisms was amplified from 31 of 112 blood samples (27.7%). dna consistent with bartonella clarridgeiae 15 (13.4%), bartonella henselae 14 (12.5%), 'candidatus m haem ...	2006	16443383
antibodies to rickettsia rickettsii, rickettsia typhi, coxiella burnetii, bartonella henselae, bartonella quintana, and ehrlichia chaffeensis among healthy population in minas gerais, brazil.	rickettsial diseases except those belonging to spotted fever group rickettsioses are poorly studied in south america particularly in brazil where few epidemiological reports have been published. we describe a serosurvey for rickettsia rickettsii, r. typhi, coxiella burnetii, bartonella henselae, b. quintana, and ehrlichia chaffeensis in 437 healthy people from a brazilian rural community. the serum samples were tested by indirected micro-immunoflourescence technique and a cutoff titer of 1:64 wa ...	2006	16444416
[presence of bartonella henselae in cats: natural reservoir quantification and human exposition risk of this zoonoses in chile].	the availability of a serologic test for cat scratch disease in humans has allowed the diagnosis of an increasing number of cases of this disease in chile.	2006	16446874
hepatic peliosis (bacillary angiomatosis) in aids: ct findings.		2006	16447083
bartonella quintana associated neuroretinitis.	we report an observational case of bartonella quintana-associated neuroretinitis. the patient had a positive igm ifa titer for bartonella quintana early in the disease. after treatment, the neuroretinitis and igm resolved. given the patient's history, symptoms, response to treatment, and igm course, we believe his neuroretinitis was secondary to bartonella quintana.	2006	16449005
bacillary angiomatosis associated with pseudoepitheliomatous hyperplasia.	bacillary angiomatosis is an opportunistic bacterial infection caused by either bartonella henselae or b. quintana. the classic histologic presentation of bacillary angiomatosis involves three components: a lobular proliferation of capillaries with enlarged endothelial cells, neutrophilic debris, and clumps of finely granular material identified as bacteria with staining techniques. pseudoepitheliomatous hyperplasia is a histologic reaction pattern characterized by epithelial proliferation in re ...	2006	16456322
ocular manifestation of cat-scratch disease in hiv-positive patients.	to characterize ocular manifestations of cat-scratch disease in hiv-positive patients.	2006	16458711
a bartonella vinsonii berkhoffii typing scheme based upon 16s-23s its and pap31 sequences from dog, coyote, gray fox, and human isolates.	since the isolation of bartonella vinsonii subspecies berkhoffii from a dog with endocarditis in 1993, this organism has emerged as an important pathogen in dogs and as an emerging pathogen in people. current evidence indicates that coyotes, dogs and gray foxes potentially serve as reservoir hosts. based upon sequence differences within the 16s-23s its region and pap31 gene, we propose a classification scheme that divides b. vinsonii subsp. berkhoffii isolates into four distinct types. two conse ...	2006	16460911
antimicrobial susceptibility of bartonella henselae using etest methodology.	bartonella henselae is a fastidious slow growing pathogen which is seldom cultured in the laboratory. previous descriptions of antimicrobial susceptibility have been largely limited to feline isolates and/or laboratory reference strains, with no accounting for genotypic or phenotypic diversity.	2006	16464897
a serological study of exposure to arthropod-borne pathogens in dogs from northeastern spain.	there is limited information regarding the prevalence of many vector borne pathogens in europe and especially in spanish dogs. we investigated 206 sick and 260 clinically healthy dogs from three different regions in northeastern spain for antibodies to rickettsia conorii (rc), ehrlichia canis (ec), anaplasma phagocytophilum (ap), bartonella henselae (bh), bartonella vinsonii subsp. berkhoffii (bvb), leishmania infantum (li) and borrelia burgdorferi (bb) and for antigen of dirofilaria immitis (di ...	2006	16472522
antibodies to bartonella vinsonii subsp. berkhoffii in moroccan dogs.	bartonella vinsonii subsp. berkhoffii is a fastidious microorganism that has been recognized as an emerging human and canine pathogen. we report for the first time on the prevalence of antibodies to b. vinsonii subsp. berkhoffii in domestic dogs from morocco. the overall seroprevalence was 38% (56 of 147 dogs tested). most of the seropositive dogs were stray dogs from rabat (36%, 8 of 22) and khenifra (47%, 47 of 101). antibodies against b. vinsonii subsp. berkhoffii were found infrequently amon ...	2006	16474074
purification of the yada membrane anchor for secondary structure analysis and crystallization.	non-fimbrial adhesins, such as yersinia yada, moraxella uspa1 and a2, haemophilus hia and hsf, or bartonella bada, represent an important class of molecules by which pathogenic proteobacteria adhere to their hosts. they form trimeric surface structures with a head-rod-anchor architecture. whereas their head and rod domains may be of heterologous origin, their anchor domains are homologous and display the properties of autotransporters. conflicting topology models exist for these membrane anchors ...	2006	16405993
dna examination of ancient dental pulp incriminates typhoid fever as a probable cause of the plague of athens.	until now, in the absence of direct microbiological evidence, the cause of the plague of athens has remained a matter of debate among scientists who have relied exclusively on thucydides' narrations to introduce several possible diagnoses. a mass burial pit, unearthed in the kerameikos ancient cemetery of athens and dated back to the time of the plague outbreak (around 430 bc), has provided the required skeletal material for the investigation of ancient microbial dna.	2006	16412683
plasmacytoid monocytes in cat scratch disease with special reference to the histological diversity of suppurative lesions.	it has been suggested that plasmacytoid monocytes (pmos) play an essential role in t-cell-dependent immune response. indeed, numerous pmos are found in close topographical association with epithelioid cell granulomas in hypersensitivity-type granulomas, such as tuberculosis and sarcoidosis. the key pathologic process in cat scratch disease (csd) usually involves a b-cell-associated granulomatous reaction. histologically, csd appears to exhibit a histopathologic diversity, including suppurative l ...	2006	16352403
bartonella quintana endocarditis with positive serology for coxiella burnetii.	both bartonella quintana and coxiella burnetii are known to cause of blood culture negative endocarditis. in such case, the diagnosis is usually established by serology. a case of bartonella quintana endocarditis is described where the serology was falsely positive for coxiella burnetii. this case demonstrates the difficulty in distinguishing these two etiologic agents by routine serologic testing.	2006	16386308
antiangiogenic effect of erythromycin: an in vitro model of bartonella quintana infection.	bartonella quintana, the etiological agent of bacillary angiomatosis (ba), causes endothelial cell proliferation. erythromycin has dramatic effects on ba, and the effects are largely unexplained by the compound's bacteriostatic properties. our aim here was to evaluate the possibility that erythromycin alters angiogenesis.	2006	16388485
effects of cow age and pregnancy on bartonella infection in a herd of dairy cattle.	bartonella spp. are small hemotropic bacteria infecting mammals. four bartonella species have been recently described in cattle and wild ruminants. to date, the biology and possible pathogenic role of bartonella species isolated from ruminants are poorly understood. therefore, a dairy herd of 448 cows and heifers was surveyed in order to establish the prevalence of bartonella bovis and b. chomelii infections, the level of bacteremia, and the relationship between bacteremia and age or pregnancy s ...	2006	16390945
first isolation of bartonella alsatica from a valve of a patient with endocarditis.	we report the first documented case of endocarditis in a man infected with bartonella alsatica, which causes bacteremia in healthy wild rabbits. b. alsatica was identified by serology and culture and by pcr of an aortic valve specimen. b. alsatica should be added to the list of zoonotic agents of blood culture-negative endocarditis.	2006	16390990
bartonella henselae infection associated with guillain-barre syndrome.	this is the first report of guillain-barré syndrome (gbs) related to bartonella henselae infection. a 10-year-old girl had difficulty walking and marked myalgia. the search for all causes known to trigger gbs was negative. she was treated with intravenous immunoglobulins and recovered. because she lived in a rural area and had a history of kitten contact, a specific serology for b. henselae infection was performed and confirmed an ongoing infection. she did not show any clinical typical feature ...	2006	16395116
evidence for louse-transmitted diseases in soldiers of napoleon's grand army in vilnius.	many soldiers in napoleon's grand army died of infectious diseases during its retreat from russia. because soldiers were commonly infested with body lice, it has been speculated that louse-borne infectious diseases, such as epidemic typhus (caused by rickettsia prowazekii), were common.	2006	16323139
prevalence of bartonella species, haemoplasma species, ehrlichia species, anaplasma phagocytophilum, and neorickettsia risticii dna in the blood of cats and their fleas in the united states.	ctenocephalides felis were killed and collected from 92 cats in alabama, maryland, and texas. the fleas and blood from the corresponding cat were digested and assessed in polymerase chain reaction assays that amplify dna of ehrlichia species, anaplasma phagocytophilum, neorickettsia risticii, mycoplasma haemofelis, 'candidatus m haemominutum' and bartonella species. dna consistent with b henselae, b clarridgeiae, m haemofelis, or 'candidatus m haemominutum' was commonly amplified from cats (60.9 ...	2006	16290092
role of dendritic cell-derived cxcl13 in the pathogenesis of bartonella henselae b-rich granuloma.	dendritic cells (dcs) initiate adaptive immunity and regulate the inflammatory response by producing inflammatory chemokines. this study was aimed to elucidate their role in the pathogenesis of the suppurative granuloma induced by bartonella henselae infection, which characterizes cat scratch disease (csd). in vitro dc infection by b. henselae results in internalization of bacteria, phenotypic maturation with increased expression of hla-dr and cd86, and induction of cd83, cd208, and ccr7. in com ...	2006	16189275
bartonella quintana endocarditis in dogs.	we provide the first evidence that bartonella quintana can infect dogs and cause typical signs of endocarditis. using pcr and sequencing, we identified b. quintana in the blood of a dog from the united states with aortic valve endocarditis and probably also in the mitral valve of a dog from new zealand with endocarditis.	2006	17326937
bartonellosis: suggestive case reports in adult and pediatric patients and therapeutic issues.	cat-scratch disease warrants extensive investigation, from an epidemiological, a diagnostic, but especially a therapeutic point of view. two suggestive episodes of bartonella henselae-caused cat-scratch disease are reported, and discussed in the light of the most recent literature evidence. the first case occurred in a 60-year-old man, thus suggesting that it is important to maintain an elevated level of suspicion for this disease in adults as well. both episodes were characterized by a very pro ...	2006	17420917
emergence of distinct genetic variants in the population of primary bartonella henselae isolates.	bartonella henselae isolates from different hosts display a marked genetic heterogeneity, as determined by pulsed-field gel electrophoresis (pfge). the aim of the present study was to determine whether different genetic variants may coexist within the population of distinct b. henselae isolates and could be detected by pfge. three primary b. henselae isolates and the b. henselae reference strains atcc 49793 and 49882 were subjected as single colony derived cultures in quadruplicate to pfge analy ...	2006	16697237
autoimmunohistochemistry: a new method for the histologic diagnosis of infective endocarditis.	although the pathologic examination of cardiac valves remains the reference standard for the diagnosis of infective endocarditis, the detection of microorganisms often poses a challenge for pathologists. this can be done by use of nonspecific histochemical stains or by immunohistochemical analysis, but specific antibodies are often not available. we describe a novel method for the detection of microorganisms in valve specimens from patients with infective endocarditis.	2006	16703515
bartonella spp. in pets and effect on human health.	among the many mammals infected with bartonella spp., pets represent a large reservoir for human infection because most bartonella spp. infecting them are zoonotic. cats are the main reservoir for bartonella henselae, b. clarridgeiae, and b. koehlerae. dogs can be infected with b. vinsonii subsp. berkhoffii, b. henselae, b. clarridgeiae, b. washoensis, b. elizabethae, and b. quintana. the role of dogs as an important reservoir of bartonella spp. is less clear than for cats because domestic dogs ...	2006	16704774
new insight into the diagnosis of fastidious bacterial endocarditis.	sterile blood cultures are noted in one third of patients with infectious endocarditis. although in half of cases this is due to previous antibiotic therapy, in the other half, the aetiology of culture-negative endocarditis is intracellular bacteria such as coxiella burnetii or fastidious growing bacteria. although it was previously considered that the prevalence of such organisms was identical throughout the world, recent investigations on bartonella endocarditis clearly showed that the aetiolo ...	2006	16706783
environmental signals generate a differential and coordinated expression of the heme receptor gene family of bartonella quintana.	of all bacteria, bartonella quintana has the highest reported in vitro hemin requirement, yet an explanation for this remains elusive. to produce diseases such as trench fever, endocarditis, and bacillary angiomatosis, b. quintana must survive and replicate in the disparate environments of the pediculus humanus corporis (body louse) gut and the human vasculature. we previously identified a five-member family of hemin binding proteins (hbps) synthesized by b. quintana that bind hemin on the outer ...	2006	16714552
binding of bartonella henselae to extracellular molecules: identification of potential adhesins.	bartonella henselae, the etiologic agent of cat scratch disease, bacillary angiomatosis and other clinical syndromes initiates infection through a trauma or wound to the skin suggesting involvement of extracellular matrix molecules. we have demonstrated in this study that b. henselae bound strongly fibronectin, collagen ix and x, but comparatively less laminin and collagen iv. b. henselae bound primarily the n- and c-terminal heparin (hep-1 and hep-2, respectively) and the gelatin-binding domain ...	2006	16725305
louse-borne bacterial pathogens in lice (phthiraptera) of rodents and cattle from egypt.	we collected 1,023 lice, representing 5 species, from rats and domestic cattle throughout 13 governorates in egypt and tested these lice for anaplasma marginale, bartonella spp., brucella spp., borrelia recurrentis, coxiella burnetii, francisella tularensis, and rickettsia spp. by pcr amplification and sequencing. five different louse-borne bacterial agents were detected in lice from rodents or cattle, including "bartonella rattimassiliensis", "b. phoceensis", and bartonella sp. near bartonella ...	2006	16729688
bartonella quintana coinfection with mycobacterium avium complex and cmv in an aids patient: case presentation.	as a greater number of hiv-infected patients survive despite profound immunodepression due to medical progress, we face complex infection with multiple agents in aids-patients.	2006	16732891
evaluation of the relationship between causative organisms and clinical characteristics of infective endocarditis in dogs: 71 cases (1992-2005).	to evaluate microbiologic findings in dogs with infective endocarditis (ie) and determine whether there were differences in clinical features of disease caused by different groups of infective agents.	2006	16740074
multifocal osteomyelitis in a child: a rare manifestation of cat scratch disease: a case report and systematic review of the literature.	we present a case of a 9-year-old immunocompetent girl who presented with pain in her left elbow and a painful swelling at her left clavicle. she had no lymphadenopathy or fever. four hot spots were seen at her left clavicle, proximal and distal left humerus and lumbo-sacral spine on a bone scan. a magnetic resonance imaging showed an inflammatory process with bone destruction at her clavicle. serological testing and polymerase chain reaction performed on a bone biopsy identified a bartonella he ...	2006	16751739
aetiological diagnosis of infective endocarditis by direct amplification of rrna genes from surgically removed valve tissue. an 11-year experience in a finnish teaching hospital.	the aetiology of infective endocarditis (ie) can be determined directly from surgically removed valve tissue using broad-range bacterial rdna polymerase chain reaction (pcr) followed by sequencing. we sought to assess the value of this methodology in a routine clinical setting.	2006	16754257
[submandibular tumor].		2006	16756901
isolation of bartonella henselae dna from the peripheral blood of a patient with cat scratch disease up to 4 months after the cat scratch injury.	we report the case of a girl with cervical lymphadenitis and a persistent primary lesion of cat scratch disease (csd). bartonella henselae dna was isolated from plasma samples collected 3 and 4 months after the cat scratch, indicating that recurrent and long-term shedding of bartonella dna into peripheral blood may occur in typical csd.	2006	16757642
etiological diagnosis of blood-culture-negative endocarditis.		2006	16762253
[endocarditis due to bartonella spp. three new clinical cases and spanish literature review].	infections by bartonella spp. include a wide spectrum of emerging and re-emerging infectious diseases, such as culture-negative endocarditis.	2006	16762254
possible role of tick-borne infection in "cat-scratch disease": comment on the article by giladi et al.		2006	16802385
borrelia, coxiella, and rickettsia in carios capensis (acari: argasidae) from a brown pelican (pelecanus occidentalis) rookery in south carolina, usa.	argasid ticks are vectors of viral and bacterial agents of humans and animals. carios capensis, a tick of seabirds, infests the nests of brown pelicans, pelecanus occidentalis, and other ground nesting birds along the coast of south carolina. this tick is associated with pelican nest abandonment and could pose a threat to humans visiting pelican rookeries if visitors are exposed to ticks harboring infectious agents. we collected ticks from a pelican rookery on deveaux bank, south carolina and sc ...	2006	16821092
multispacer typing to study the genotypic distribution of bartonella henselae populations.	bartonella henselae, a worldwide fastidious bacterium, has a feline reservoir and is pathogenic for humans. however, the relationship between human and cat isolates of b. henselae, as well as its population dynamics and geographic heterogeneity, is not fully understood, in part because of the absence of appropriate typing methods. multilocus sequence typing (mlst), the most discriminatory genotyping method for b. henselae, identified seven genotypes and suggested that human isolates arose from a ...	2006	16825371
disseminated bartonella infection following liver transplantation.	bartonella henselae has not only been identified as the causative agent of cat scratch disease, but it is also associated with other significant infectious syndromes in the immunocompromised population. we describe two cases of b. henselae associated diseases in liver transplant recipients who both had contact with cats. the first recipient developed localized skin manifestation of bacillary angiomatosis in association with granulomatous hepatitis. he tested positive for immunoglobulin g (igg) a ...	2006	16827686
rodent-associated bartonella febrile illness, southwestern united states.	serum specimens from 114 patients hospitalized with a febrile illness were tested with an indirect immunofluorescence assay (ifa) using bartonella antigens prepared from 6 species of sigmodontine rodents and 3 known human bartonella pathogens: b. henselae, b. quintana, and b. elizabethae. acute- and convalescent-phase serum samples from 5 of these patients showed seroconversion with an ifa titer >512 to rodent-associated bartonella antigens. the highest titer was against antigen derived from the ...	2006	16836824
surveillance of egyptian fleas for agents of public health significance: anaplasma, bartonella, coxiella, ehrlichia, rickettsia, and yersinia pestis.	serologic surveys in egypt have documented human and animal exposure to vector-borne bacterial pathogens, but the presence and distribution of these agents in arthropods has not been determined. between july 2002 and july 2003, fleas were collected from 221 mammals trapped in 17 cities throughout egypt. a total of 987 fleas were collected, representing four species (ctenocephalides felis, echidnophaga gallinacea, leptopsylla segnis, and xenopsylla cheopis); 899 of these fleas were x. cheopis fro ...	2006	16837707