Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| serology in helicobacter pylori infection. | 1993 | 8280937 | |
| immunisation against gastric infection with helicobacter species: first step in the prophylaxis of gastric cancer? | the discovery of the gastric bacterium, helicobacter pylori and the demonstration of its role in the pathogenesis of gastroduodenal disease, has been one of the major microbiological advances in the last decade. recent demonstration of long term infection with this bacterium as a risk factor in gastric carcinoma suggests that intervention in a disease of major morbidity and mortality is possible. using a model of helicobacter infection in mice it has been shown that oral immunisation with a soni ... | 1993 | 8280938 |
| stimulatory effects of helicobacter pylori on human peripheral blood mononuclear cells of h. pylori infected patients and healthy blood donors. | the ability of 23 different strains of helicobacter pylori to induce proliferative response of human peripheral blood mononuclear cells (pbmc) was investigated. all tested strains stimulated the dna synthesis of pbmc from both healthy and h. pylori infected blood donors, but with lower stimulation of pbmc of infected donors. using different bacterial antigen preparations, such as crude membranes, cytoplasmic proteins, and urease, a significantly lower induction of the proliferative response of p ... | 1993 | 8280939 |
| role of the systemic cellular immune response in the pathogenesis of helicobacter pylori-associated duodenal ulcer. | 20 patients colonized by h. pylori (9 with duodenal ulcer, 11 with antral gastritis) were examined for the presence of a systemic cellular immune response to h. pylori using an in vitro lymphocyte transformation assay. infiltration of the antral mucosa by myelomonocytic cells was assessed by immunohistology as a parameter of local cellular immune response. a systemic h. pylori-induced cellular reaction could be demonstrated in 11 patients all of whom showed an intense myelomonocytic infiltration ... | 1993 | 8280940 |
| humoral and cellular immunity in hiv positive and hiv negative helicobacter pylori infected patients. | the prevalence of h. pylori associated gastritis seems to be different in hiv positive and hiv negative patients. therefore a correlation to immunodeficiency can be postulated. the histology of gastritis, status of h. pylori infection and parameters of humoral and cellular immune response were investigated in 41 hiv positive and 47 hiv negative patients, who were subjected to upper endoscopy for the evaluation of gastrointestinal symptoms. in hiv positive patients 37% had active chronic gastriti ... | 1993 | 8280941 |
| neutralising antibodies to the vacuolating toxin of helicobacter pylori in gastritis only and peptic ulcer patients. | sera from 36 patients with gastritis only and 26 patients with peptic ulcer were tested for the presence of neutralising antibodies against h. pylori vacuolating toxin. the frequency with which sera did neutralise the vacuolating toxin was not significantly different among the groups of patients with gastroduodenal ulcer infected either with toxigenic or nontoxigenic h. pylori strains (9/14 vs 4/12; ns) or in patients with gastritis only harbouring toxigenic h. pylori strains (8/12). by contrast ... | 1993 | 8280942 |
| performance of helicobacter pylori acid extract and urease enzyme-linked immunosorbent assays in relation to 14c-urea breath test. | the 14c-urea breath test has been shown to be a reliable non-invasive method to detect the presence or absence of h. pylori infection. alternatively, a number of techniques have been devised to detect circulating antibodies against h. pylori in serum, the most commonly used being enzyme-linked immunosorbent assays (elisa). in the present study we compared the value of two elisa antigen preparations, an acid glycine extract and a urease preparation, in relation to the results achieved in a 14c-ur ... | 1993 | 8280943 |
| helicobacter pylori antibodies in sera of children suffering from chronic abdominal pain. | 107 pediatric patients aged 9 to 18 with persistent gastric complaints were examined serologically and bacteriologically for helicobacter pylori. helicobacter was identified in 48 (45%) of individuals. 51 (48%) of children were found to be seropositive when h. pylori antibodies were detected by the elisa; 56 (52%) when the passive haemagglutination test was used, and 41 (38%) in the latex agglutination test. 25% of culture-negative patients were found to be seropositive. the percentage of raised ... | 1993 | 8280944 |
| comparison of four second generation kits for detection of igg antibodies against helicobacter pylori in adults. | four serological kits for detection of igg antibodies against h. pylori were tested on 132 adult patients with dyspeptic symptoms. presence of h. pylori infection was established when either culture or microscopy of gastric biopsies were positive. the prevalence of h. pylori infection was 55% in the test population. with anti-h. pylori mtp-assay (roche), pylori stat test kit (whittaker), hm-cap (enteric products inc.) and pyloriset eia-g (orion) the sensitivities were 97%, 95%, 81% and 68% respe ... | 1993 | 8280945 |
| in vitro susceptibility testing of helicobacter pylori to antimicrobial agents: basis for treatment or microbiologists' obsession? | 1993 | 8280946 | |
| antibacterial activity of teprenone, a non water-soluble antiulcer agent, against helicobacter pylori. | teprenone, a non water-soluble antiulcer agent, is a derivative of terpene. the antibacterial activity of teprenone against helicobacter pylori was examined by the disc method and survival test in albumin broth including teprenone. growth of h. pylori around the disc charged with teprenone was inhibited on brucella agar supplemented with bovine serum albumin fraction v, charcoal, or beta-cylodextrin, but not with blood or egg yolk emulsion. furthermore, when h. pylori was exposed in broth includ ... | 1993 | 8280947 |
| therapeutics used to alleviate peptic ulcers inhibit h. pylori receptor binding in vitro. | treatment with bismuth-containing remedies has been long associated with the alleviation of minor gastric ailments. bismuth salts have a potent antimicrobial activity, and are part of the current standard regime used to treat helicobacter pylori infection. h. pylori is considered to be the major etiological factor in the development of peptic ulcer disease. earlier efficacious treatments for peptic ulcer included the oral administration of tween detergents. we have found that these agents have a ... | 1993 | 8280948 |
| effects of substances inhibiting or uncoupling respiratory-chain phosphorylation of helicobacter pylori. | the effects of electron transport inhibitors and uncoupling agents as well as of bismuth compounds on the respiratory activity and oxidative phosphorylation of helicobacter pylori were investigated. bismuth gallate and bismuth subsalicylate reduced the respiratory chain-dependent phosphorylation. inhibition was of the same magnitude as that observed with other known inhibitors. it is concluded that bismuth displays an antibacterial effect by inhibiting the respiratory chain of h. pylori. | 1993 | 8280949 |
| coccoid like forms (clf) of helicobacter pylori. enzyme activity and antigenicity. | in this study we attempted to transform "helical" forms of helicobacter pylori to "coccoid like forms" (clf) by induction with the following substances in vitro: bismuth subcitrate, bismuth subsalicylate, ampicillin, amoxicillin, erythromycin, ursodeoxycholic acid and glycochenodeoxycholic acid. some liquid cultures were incubated for 24 days to induce clf by aging. changes in the protein pattern, urease enzyme activity and in the serological response against specific antigens were investigated. ... | 1993 | 8280950 |
| influence of omeprazole on urease activity of helicobacter pylori in vitro. | the influence of omeprazole on urease activity of 13 helicobacter pylori strains was assessed in vitro employing different inocula of the bacteria and various concentrations of omeprazole. bacteria were grown in liquid culture supplemented with omeprazole for 48 h. afterwards, bacterial numbers were assessed and urease activity was measured in a spectrophotometric assay. in 10 strains, omeprazole had no influence on urease activity at concentrations up to 8 mg/l; higher concentrations had a bact ... | 1993 | 8280951 |
| activity of antibiotics and azole antimycotics against helicobacter pylori. | the bacteristatic and bactericidal activities of six antibiotics from different substance classes against helicobacter pylori were determined. ampicillin, imipenem, tetracycline, and amikacin inhibit the growth of all isolates at concentrations achievable in serum. cefpirome and ofloxacin are ineffective against three and two of 41 strains, respectively. however, the minimum bactericidal concentrations (mbc) of the substances are two- to sixteen-fold higher than the minimum inhibitory concentrat ... | 1993 | 8280952 |
| animal models of bacterial gastritis: the role of host, bacterial species and duration of infection on severity of gastritis. | gastric bacteria from cheetahs with gastritis were used to inoculate specific-pathogen free kittens and conventional mice. helicobacter sp. and gastrospirillum sp. colonized kittens, while only gastrospirillum sp. colonized mice. in kittens, both bacterial species induced mild lymphofolliclar gastritis which did not change over the course of the 11 months observation period. in mice, gastrospirillum sp. induced lymphoplasmacytic and follicular gastritis which increased in severity over 6 months ... | 1993 | 8280953 |
| prevalence of helicobacter pylori in gastrointestinal disorders and concentrations of ciprofloxacin in serum and gastric mucosa. | endoscopic antral biopsies were obtained from 30 patients with several gastrointestinal disorders and analysed for the presence of h. pylori. this bacterium was present in 80% and 58%, respectively, of patients with either gastric and duodenal ulcers and gastric neoplasm. in none of the healthy individuals, h. pylori could be found. another 14 patients with various diseases of the stomach, undergoing a major gastric resection, had been treated with 200 mg ciprofloxacin intravenously immediately ... | 1993 | 8280954 |
| long term infection of the gastric mucosa with helicobacter species does induce atrophic gastritis in an animal model of helicobacter pylori infection. | gastric atrophy is a precursor lesion in the development of gastric cancer. it has been proposed that atrophy is part of a natural progression of inflammatory changes that result from long term infection with the bacterium helicobacter pylori. the aim of this study was to test this hypothesis using an animal model of human helicobacter infection. conventional mice were infected with either a cat isolate of helicobacter felis or a human isolate of "gastrospirillum hominis". all infected mice show ... | 1993 | 8280955 |
| discovery of "curved bacilli" in the stomach. | 1993 | 8280956 | |
| serial change of gastric mucosa after challenging with helicobacter pylori in the cynomolgus monkey. | the aim of this study was to clarify the change of the gastric mucosa following inoculation with helicobacter pylori (h. pylori). two pairs of cynomolgus monkeys received either h. pylori of human origin (group a) or h. pylori of monkey origin (group b) by intragastric inoculation at a dose of 10(9) cfu. after inoculation, endoscopical observation and biopsies were done every 7 days for one month. the bacteria in the biopsy samples were cultured quantitatively. the content of intracellular pas-a ... | 1993 | 8280957 |
| interaction of helicobacter pylori (strain 151) and campylobacter coli with human peripheral polymorphonuclear granulocytes. | helicobacter pylori associated gastritis is characterized by dense mucosal inflammatory infiltrations with predominantly neutrophilic granulocytes, together with a local and systemic immune response. nevertheless, the natural course of the infection is chronic in nature, and active phagocytosis of h. pylori by mucosal granulocytes was only rarely observed. the aim of the present study was to investigate with electronmicroscopic methods the interaction of h. pylori with freshly harvested human pe ... | 1993 | 8280958 |
| the evangelism of helicobacter pylori: how to convince the non-believers and curb the believers. | 1993 | 8280959 | |
| in situ localization of the 60 k protein of helicobacter pylori, which belongs to the family of heat shock proteins, by immuno-electron microscopy. | the groel homologue of helicobacter pylori was isolated and characterized by means of immunoelectron microscopy, after cryosectioning. the 60 k protein was isolated from helicobacter pylori by treatment of the cells with 2-butanol and purified by anion exchange chromatography. the native molecular weight of the 60 k protein was estimated to be 420 k by size exclusion chromatography. the purified 60 k protein showed the typical rotational symmetry of chaperonins when analyzed by electron microsco ... | 1993 | 8280960 |
| activation of human phagocytes by helicobacter pylori. a novel interaction with neutrophils and monocytes distinct from that of n-formylated oligopeptides. | sonicate proteins from helicobacter pylori activate human neutrophils and monocytes for chemotactic and oxidative burst responses. the molecular nature of this activity and its interaction with the phagocyte membrane is unknown. cross-stimulation experiments were performed with human neutrophils and monocytes preincubated in h. pylori sonicate and subsequently stimulated with the established and characterised stimuli n-f-methionyl-leucyl-phenylalanine (fmlp), the complement split product c5a (in ... | 1993 | 8280961 |
| epidemiology of, and risk factors for, helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. the eurogast study group. | the cross sectional study describes the prevalence of infection with helicobacter pylori as determined by a serodiagnostic assay in over 3000 asymptomatic subjects, in two age groups 25-34 years and 55-64 years, from 17 geographically defined populations in europe, north africa, north america, and japan, using a common protocol for blood collection and serological testing. in all populations combined, the prevalence of infection was higher in the older age group (62.4%) than in the younger age g ... | 1993 | 8282253 |
| prevalence of helicobacter pylori infection and its effect on symptoms and non-steroidal anti-inflammatory drug induced gastrointestinal damage in patients with rheumatoid arthritis. | non-steroidal anti-inflammatory drugs (nsaids) and helicobacter (h pylori) are both associated with an increased risk of peptic ulceration and gastropathy. it is not known, however, if there is an interaction between these two agents, and thus whether or not screening for h pylori before nsaid treatment is of value. the aim of this study was to find out if h pylori potentiates the damaging effects of nsaids. fifty two patients with rheumatoid arthritis requiring longterm nsaid treatment were stu ... | 1993 | 8282254 |
| when is helicobacter pylori infection acquired? | cross sectional surveys have shown an increasing prevalence of helicobacter pylori (h pylori) infection with increasing age in western populations. the aim of this study was to examine the pattern of acquisition of h pylori infection over a 21 year period in a group of 141 adults who had blood samples and serum stored in 1969, 1978, and 1990. a prevalence of h pylori antibody of 39% in 1969 serum samples, 40.9% in 1978, and 34.8% in 1990 was found when assessed by an enzyme linked immunosorbent ... | 1993 | 8282255 |
| lipid analysis of helicobacter pylori. | lipids from helicobacter pylori were extracted, isolated by conventional deae-sephadex and silica gel column chromatography, and then purified by preparative thin-layer chromatography. simple and phospholipids were analyzed by hptlc and quantitatively determined by densitometry scanning. the fatty acid compositions of simple lipids were estimated by gas-liquid chromatography. the simple lipid composition of h. pylori consisted of wax ester (2.5%), triglycerides (4.9%), free fatty acids (30.0%), ... | 1993 | 8283008 |
| significance of serum markers pepsinogen i and ii for chronic atrophic gastritis, peptic ulcer, and gastric cancer. | chronic atrophic gastritis (cag) is closely correlated with gastric cancer and is predominant in japan. epidemiologically, food habits are the primary factor in both cag and gastric cancer. two potential serum markers for cag have recently been investigated, i.e., the concentration of serum pepsinogen (pg) and the presence of serum antibodies against helicobacter pylori. serum pg i and ii and the pg i:pg ii ratio have been reported to be useful as indicators of recurrent peptic ulcer and for scr ... | 1993 | 8283010 |
| [histology of helicobacter pylori (hp) infection: gastric local immunity to hp]. | 1993 | 8283613 | |
| [helicobacter pylori and gastroduodenal diseases: current status]. | 1993 | 8283614 | |
| [bacteriological status, serotypes, and biotypes of helicobacter pylori]. | to divide h. pylori strains into subgroup for an etiological survey, some attempts have been made to determine serotypes or biotypes. a variety of serogroups was observed with a slide agglutination test between s. aureus sensitized with antisera and cells of h. pylori (danielson et al, 1988). three or more serotypes were obtained by using antisera absorbed with heterogeneous strains (tanaka et al, 1990). furthermore, the possible existence of serological subgroups or subtypes by elisa was observ ... | 1993 | 8283615 |
| [lipid composition of helicobacter pylori]. | in h. pylori, we examined the composition of total lipids. in thin-layer chromatography, three kinds of glycolipids were detected, which were named as g-1, g-2 and g-3. g-3 contained phosphates in addition to sugars. total lipids consisted of 6.0% neutral lipids (weight %), 20.6% glycolipids (g-1, g-2) and 73.4% phospholipids (including g-3). total glycolipids were approximately 25% of total lipids. after methanolysis, cholesterol was detected in the hexane extractable fraction and glucose was d ... | 1993 | 8283616 |
| [epidemiological studies and mode of transmission of helicobacter pylori infection]. | recent epidemiological reports of helicobacter pylori (hp) reveal that hp is distributed among all populations in the world. the prevalence rate in the developed countries is generally, lower than that in the developing countries. the prevalence of hp increases with age both in the developed and the developing countries, reflecting a socioeconomic status; the poorer a population, the earlier is the age of infecting hp, resulting in the higher prevalence rate of hp. the epidemiological evidence i ... | 1993 | 8283617 |
| [the possibility of transendoscopic transmission of helicobacter pylori and the method of disinfection of endoscopic instruments]. | although helicobacter pylori (hp) infection has been considered to have an etiologic role in the development of antral gastritis and recurrence of duodenal ulcer, the source and normal route of transmission of hp remains unknown. ironically, iatrogenic infection was the first route of transmission established. through many investigations using hp dna analysis and anti-hp antibody change, the possibility of transendoscopic transmission of hp has been determined. from the fundamental analysis of t ... | 1993 | 8283618 |
| [experimental infection of the cynomolgus monkey with helicobacter pylori]. | to better understand the pathogenesis of helicobacter pylori (h. pylori) associated gastritis and to evaluate the effectiveness of potential therapies in ulcer healing, we established an experimental animal model of h. pylori infection. a strain of h. pylori was isolated from the stomach of a cynomolgus monkey, cultured and used to inoculate as a group of h. pylori negative monkeys. h. pylori-induced changes in the gastric mucosa was monitored both endoscopically and by histological evaluation o ... | 1993 | 8283619 |
| [experimental study in japanese monkeys with helicobacter pylori infection]. | japanese monkeys were studied for one month from 6 months (short-term) after inoculation of helicobacter pylori, and two years (long-term). in the short-term study, macroscopic and histological gastritis were observed for 5 infected monkeys. the gastritis score, the ammonia concentration in the gastric secretion and the level of serum antibody (igg) were higher for the infected group than for the control. in the long term study, h. pylori was always recovered for 2 years in the infected group, a ... | 1993 | 8283620 |
| [experimental animal models in mongolian gerbils and mice]. | helicobacter pylori is an emerging candidate agent for the genesis of chronic gastritis and peptic ulcer. there have been many challenges to establish an experimental infection with h. pylori in animals. in recent, several studies reported for animal infection with this organism. one of them was the study using urinary system. the study indicated the ability of h. pylori to induce inflammation without significant low ph condition. experimental infection in mongolian gerbils showed that h. pylori ... | 1993 | 8283621 |
| [adhesion of helicobacter pylori--role of glycolipid adhesion receptors]. | in the gastric mucosa, the composition of acidic glycolipids has unique feature of enrichment of sulfatides over gangliosides. immunohistochemical staining using a monoclonal antibody demonstrated that the sulfated glycolipids specifically localized on surface epithelial cells. moreover, cultured gastric mucosal cells actively synthesized sulfated glycolipids. we have also shown that it may be recognized as an adhesion receptor by helicobacter pylori (hp). since other investigators have proposed ... | 1993 | 8283622 |
| [helicobacter pylori and urease activity--comparative study between urease positive and negative mutant strains]. | the ammonia concentration in the gastric juice from h. pylori positive cases was significantly higher than that from negative cases, and there was positive correlation between number of h. pylori, gastritis score and ammonia concentration in gastric juice. it is suggested that ammonia in gastric juice which is produced by powerful urease activity of h. pylori is one of the pathogenic factors in gastritis. we succeeded in producing a urease-negative mutant strain of h. pylori. this strain did not ... | 1993 | 8283623 |
| [role of ammonia-monochloramine system in helicobacter pylori--induced gastric mucosal injury]. | monochloramine is a reactive oxidant which is yielded by the reaction of neutrophil-derived hypochlorous acid and ammonia. luminol-dependent chemiluminescence assay reveals that h. pylori directly elicits a respiratory burst of neutrophils. this activation is also observed by adding the bacterial supernatant of cultured or sonicated h. pylori, suggesting that h. pylori-derived soluble factor may be responsible for the release of chlorinated oxidants. in vitro cytotoxicity assay indicates that cu ... | 1993 | 8283624 |
| [leukotriene levels of helicobacter pylori-infected gastric mucosa]. | helicobacter pylori appears to cause chronic active gastritis, which is characterized by infiltration by neutrophils. leukotrienes (lts), which are both chemotactic and cytotoxic, are produced mainly by neutrophils. we studied lt levels, h. pylori infection and neutrophils infiltration in gastric mucosa of patients with non-ulcer dyspepsia. lt levels of mucosa infected with h. pylori were higher than that in non-infected mucosa. there was a correlation between lt levels and neutrophils infiltrat ... | 1993 | 8283625 |
| [mucinase activity of helicobacter pylori: application of simplified mucinase test]. | we conducted the simplified mucinase tests about helicobacters (helicobacter pylori, helicobacter felis and helicobacter mustelae) and campylobacter jejuni, positive controls were pseudomonas maltophilia and pseudomonas cepacia. h. pylori, h. felis and c. jejuni showed low resolution activities for hog gastric mucin, however h. mustelae had no detectable the activities. this enzymatic activity varies considerably by cultural condition of h. pylori, therefore it is difficult to compare the activi ... | 1993 | 8283626 |
| [isolation identification and quantitative culture of helicobacter pylori from gastric mucosa]. | the biopsy specimens were homogenized and diluted ten-fold serially in hank's solution. each dilution samples were streaked on skirrow's selective medium. the plates were incubated at 37 degrees c 5 to 7 days under micro-aerobic condition and counting the viable cell of h. pylori. the positive rate of specimens with h. pylori in active gastric ulcer tissue (62.0%) was higher than that in scarred tissue (51.9%). number of h. pylori viable cells in active ulcer tissue was significantly larger than ... | 1993 | 8283627 |
| [detection of helicobacter pylori by polymerase chain reaction]. | the application of pcr method to the detection of h. pylori is reviewed. in most of the assays reported to date, primer pairs based on the sequences of urease and 16s rrna genes have been chosen. clinical samples tested have ranged widely from gastric biopsy specimens to gastric aspirates, feces, dental plaques, saliva, etc. as few as one organism can be detected by the most sensitive assay. the reports suggest that pcr assay is suited for laboratory diagnosis of the organism as well as epidemio ... | 1993 | 8283628 |
| [endoscopic diagnosis of helicobacter pylori distribution in human gastric mucosa by phenol red dye spraying method]. | helicobacter pylori (h. pylori) is known to show an uneven and patchy distribution on human gastric mucosa, close association with chronic gastritis and peptic ulcer diseases. the aim of this study was to clarify the distribution of this organism under direct vision by phenol red dye spraying endoscopy. in order to maintain gastric ph around ph 4.0 to 5.0, premedication was necessary either by intravenous injection of h2-blocker, 30 min before the test, or by oral administration of omeprazole 20 ... | 1993 | 8283629 |
| [staining for helicobacter pylori on gastric mucosa with dye from red cabbage during endoscopy]. | helicobacter pylori has a high urease activity and produces ammonia from urea, resulting in elevation of mucosal ph. based on this characteristics of h. pylori, we have developed a method for staining h. pylori under endoscopy using dye from red cabbage (san-red rc, san-ei chemical ind., osaka), a ph indicator, safe for clinical use. after administration of a proton-pump inhibitor and an h2-receptor antagonist, the dye solution, mixed with 2% urea, was sprayed over the mucosa by endoscope. chang ... | 1993 | 8283630 |
| [urease test]. | in order to elucidate bacterial infection, as a rule, isolated and cultured bacteria of a specimen are identified by their morphologies or biochemical characteristics. however, the culture of helicobacter pylori (h. pylori) is difficult and takes, much time. therefore, favorable test results are currently obtained by combining the culture method, histopathologic method, urease test and sero-immunologic test. the merits of the urease test are that judgement is available immediately after endoscop ... | 1993 | 8283631 |
| [13c-urea breath test]. | the 13c-urea breath test is now a practical and readily available alternative to endoscopy- and serology-based methods for the detection of h. pylori infection. it can detect very low levels of h. pylori colonization within the stomach by assessing the entire mucosa, and avoids the risks of sampling error. we performed the 13c-urea breath test in asymptomatic volunteers and patients with gastric and duodenal ulcers in order to compare the sensitivity and specificity by measurement of h. pylori a ... | 1993 | 8283632 |
| [elisa tests for detection of helicobacter pylori antibodies]. | the efficacy of commercial elisa tests for detection of helicobacter pylori antibodies was investigated. some investigators reported that six commercial elisa tests had sensitivities of 81-96%, and had specificities of 29-96%. it is possible that some of false-negative results by elisa may occur for patients who are in the acute phase of infection. when elisa tests gave false-positive results, it should be taken into account that there might be some false negative diagnoses for the gastric h. py ... | 1993 | 8283633 |
| [prevalence and distribution of helicobacter pylori in the stomach of patients by upper gastrointestinal endoscopy]. | the prevalence of h. pylori colonization in the antrum and body was examined in patients with gastritis, duodenal ulcer (du) and gastric ulcer (gu). the total prevalence was 63.5%, 90.0% and 85.5%, respectively. in patients with gastritis and du, the frequency was similar at both sites, while in gu patients h. pylori positivity was increased markedly in the body compared with the antrum. furthermore, in patients with antral and angular ulcers, biopsy studies from 8 different sites showed that th ... | 1993 | 8283634 |
| [helicobacter pylori and gastroduodenal ulcers]. | we studied the prevalence of helicobacter pylori (h.p.) infection in gastroduodenal diseases. h.p. was positive in 67.6% of gastric ulcer patients and 82.2% of duodenal ulcer patients. h.p. was detected with high frequency throughout the course of ulcer healing. short-term antimicrobial therapy, including cefixim, ofloxacin and bismuth subnitrate, was effective in 50% of h.p. positive patients. however, h.p. was detected again in a considerable number of patients one year after the treatment. hi ... | 1993 | 8283635 |
| [role of helicobacter pylori infection in gastric metaplasia in the duodenum in the production of duodenal ulcer]. | helicobacter pylori (h. pylori) is frequently detected in not only the antrum but also the gastric juice and the duodenum with gastric metaplasia, which is believed to be a response of duodenal mucosa to injury by hyperacidity, in most of duodenal ulcer patients. conversely, the normal duodenum is not infected with h. pylori in non-duodenal ulcer patients, even if h. pylori is present in the antrum and/or the gastric juice. all patients with h. pylori in the duodenum has the h. pylori infection ... | 1993 | 8283636 |
| [the role for helicobacter pylori infection in intractable and recurrent ulcer]. | patients with intractable peptic ulcer or recurrent peptic ulcer have high rate of helicobacter pylori infection. to study the effect of h. pylori on the recurrence of peptic ulcer, we treated the patients, who had h. pylori infection, with antibiotics (amoxicillin, clarithromycin, fosfomycin). after one year, none of peptic ulcer patient in whom h. pylori was eradicated had a recurrence. among patients who remained positive for h. pylori, the ulcer relapse rate was 61% (11 of 18). in patients w ... | 1993 | 8283637 |
| [relationship between helicobacter pylori colonization in the gastric mucosa and the severity of atrophic gastritis]. | we studied the relationship between helicobacter pylori infection and atrophic gastritis. eighty non-ulcer patients underwent endoscopy with biopsy. detection and quantitative assessment of h. pylori was made based on smear, culture and tissue section (gram stain). the extent of atrophic gastritis was assessed endoscopically according to the classification of kimura and takemoto. severity of glandular atrophy and intestinal metaplasia was assessed histologically. h. pylori infection was accompan ... | 1993 | 8283638 |
| [helicobacter pylori and the development of atrophic gastritis]. | a close relationship between h. pylori infection and atrophic gastritis has been reported, and atrophic gastritis has been thought of as one of the precursors of gastric carcinoma. it was reported that there was a significant positive correlation between the reduction of serum pepsinogen (pg) i/ii ratio and the progression of atrophic gastritis. the ratio of pg i/ii was significantly decreased in h. pylori positive patients when compared to h. pylori negative patients with chronic gastritis. the ... | 1993 | 8283639 |
| [helicobacter pylori infection in gastric cancer]. | the relationship between helicobacter pylori (h. pylori) infection and gastric cancer becomes the topics in the world, since some reports thereon in 1991. the purpose of this study was to know the prevalence of h. pylori infection in many patients with gastric cancer. we examined the h. pylori igg antibody in 507 patients with gastric cancer resected surgically in our hospital from 1989 to 1991, retrospectively. for the test of h. pylori igg antibody, hm-cap eia kit (italy, enteric products co.) ... | 1993 | 8283640 |
| [helicobacter pylori and gastric cancer in view of relation to atrophy of background gastric mucosa]. | to make clinical assessment regarding the role of helicobacter pylori (h. pylori) in the occurrence of gastric cancer, we examined serological and microbiological positive rate of h. pylori and histological and endoscopic findings of atrophic gastritis of background mucosa in 149 gastric cancer patients, 136 gastric ulcer patients, 82 chronic gastritis cases and 46 normal control. serological h. pylori positive rate examined using gap-igg in 43 gastric cancer patients was 95%, which was signific ... | 1993 | 8283641 |
| [clinico-pathological study of helicobacter pylori in early gastric cancer]. | the role of helicobacter pylori (hp) infection in the pathogenesis of various gastric diseases is an important but unresolved issue. to investigate the association between hp and the histological findings of the stomach in patients of early gastric cancer, the prevalence of hp in gastric mucosa and the mucosal alterations were examined histo-pathologically in the surgically resected stomach of 30 cases with early gastric cancer. serum igg antibodies for hp were determined in these cases. all 30 ... | 1993 | 8283642 |
| [in vitro anti-microbial activity against h. pylori and clinical efficacy of various drugs]. | the in vitro antimicrobial activity against h. pylori and clinical efficacy of various antibiotics and antiulcer drugs are summarized in this study. h. pylori highly sensitive to most of the beta-lactams and macrolides. especially, amoxicillin and clarithromycin have satisfactory in vitro activity against h. pylori. the anti-ulcer drugs, sofalcon and plaunotol, used in japan as mucosal protective agents, also have a weak activity against h. pylori with mic50 12.5 micrograms/ml and mic90, 50-100 ... | 1993 | 8283643 |
| [activity of lansoprazole (new proton pump inhibitor) against helicobacter pylori and its therapeutic efficacy]. | lansoprazole, one of ppis, is a strong antacid and it cures stomach and duodenal ulcers at early stages as well as having antibiotic action towards hp. the in vitro mic of the product is between 3.13 and 12.5 micrograms/ml and it was 12.5 micrograms/ml, which was the same as mic of colloidal bismuth citrate, in our study. sterilizing effect of lansoprazole is reported to be the direct attack on hp bacteria from electron microscopic findings. our study revealed that lansoprazole would preserve th ... | 1993 | 8283644 |
| [effective regimen for eradication of helicobacter pylori]. | there is now substantial evidence that helicobacter pylori (h. pylori) is both a frequent cause of chronic gastritis and an important factor in the recurrence of duodenal ulcer. however, to achieve the eradication of h. pylori is very difficult and although a number of treatment regimens suppress this organism, the stomach usually becomes recolonized shortly after the cessation of treatment. many reports have shown that polytherapy is more effective than monotherapy. and so, the best results hav ... | 1993 | 8283645 |
| [eradication therapy of helicobacter pylori in gastroduodenal ulcer and its long-term course]. | we investigated the efficacy of antimicrobial drugs, amoxicillin and clarithromycin that have the in vitro activity against h. pylori, and observed a long term course of ulcer after eradication. the eradication rate of combination therapy with ppi and amoxicillin showed best result (13/18: 72%). in eradicated cases, index of pas positive substance and gastritis score in antral mucosa that is histological examination was improved, and ammonia concentration in gastric secretions decreased. the rec ... | 1993 | 8283646 |
| [the effect of the eradication of h. pylori on the intractable ulcer]. | on 25 cases (gastric ulcer 14 cases and duodenal ulcer 11 cases) of the intractable ulcer which was h. pylori-positive, we eradicated h. pylori. the eradication was done during 14 days by a triple therapy: bismuth subnitrate 2.0 g, metronidazole 0.75 g, ampc 0.75 g/day). all cases were confirmed to be eradicated by culture and microscopic examination. 24 cases (gastric ulcer 13/14 and duodenal ulcer 11/11) were confirmed to be completely cured. after the eradication, we ceased the maintenance th ... | 1993 | 8283647 |
| [relationship of helicobacter pylori to chronological transition of endoscopic atrophic pattern]. | the prevalence of helicobacter pylori (hp) were studied in 117 subjects with no gross findings whose stomach age was equal to its chronological age. hp was detected by culture. the prevalence of hp significantly was higher in thirties and forties than other ages, and in c3 and o1 groups than other groups. most of forties and fifties belonged to c3 or o1 groups. histologically, hp infection was significantly frequent in the gastric mucosa with advancing inflammation. these findings suggest that h ... | 1993 | 8283808 |
| [a clinical study in 4 infants with duodenal ulcer]. | 1993 | 8283815 | |
| ultrastructural localization of urease of helicobacter pylori. | helicobacter pylori urease was characterized by means of an enzyme histochemical electron microscopic technique. ultrastructural analysis revealed no urease activity in one strain; in seven h. pylori strains (43.75%), urease activity was associated with the cell membrane. eight strains (50.0%) showed reaction product located within the cytoplasm. urease activity showed no correlation with localization of activity. our results demonstrate that h. pylori urease is not uniform in all h. pylori stra ... | 1993 | 8283959 |
| chronic gastritis and helicobacter pylori in digestive form of chagas' disease. | patients with the digestive form of chagas' disease frequently present chronic gastritis. as the microorganism helicobacter pylori is now accepted as the most common cause of human chronic gastritis, the present work was undertaken to verify a possible relationship between the presence of this bacterium and inflammatory changes of antral mucosa in chagasic patients. seventeen chagasics, with megaesophagus and or megacolon were studied. fragments from two different regions of antral mucosa were o ... | 1993 | 8284595 |
| efficacy and side effects of a triple drug regimen for the eradication of helicobacter pylori. | one hundred consecutive patients with helicobacter pylori infection, as proven by culture, were treated with 120 mg colloidal bismuth subcitrate (cbs) four times daily, 250 mg tetracycline four times daily, and 250 mg metronidazole four times daily during 15 days. the patients were amply instructed in how to take the medicine and strongly urged to complete the prescribed course. in 66 of the 100 patients pretreatment metronidazole susceptibility was determined. endoscopy was performed 3 months a ... | 1993 | 8284626 |
| treatment of helicobacter pylori reduces the rate of rebleeding in peptic ulcer disease. | we evaluated whether therapy designed to eradicate helicobacter pylori infection resulted in a reduction in rebleeding in patients with peptic ulcer disease. patients presenting because of major upper gastrointestinal hemorrhage from peptic ulcer and whose ulcers healed in a study in which they were randomized to receive ranitidine alone or triple therapy plus ranitidine were followed up regularly with endoscopy. no maintenance anti-ulcer therapy was given after ulcer healing. | 1993 | 8284627 |
| parietal cell antibodies among peruvians with gastric pathologic changes. gastrointestinal physiology working group. | parietal cell antibodies were present in 12% of 272 peruvians presenting for endoscopy. gender, age, socioeconomic status, ethnic background (peruvian versus japanese), and altitude at which the patient lived were not associated with the presence of parietal cell antibodies. no significant relationship could be shown between the presence of parietal cell antibodies and either helicobacter pylori infection or gastric lesions, including chronic atrophic gastritis. loss of proper gastric glands was ... | 1993 | 8284633 |
| long-term omeprazole therapy does not affect helicobacter pylori status in most patients. | fifty-one patients were treated with 20-60 mg omeprazole for reflux oesophagitis resistant to h2-blocker therapy during a mean of 49 months of follow-up. with use of a standardized enzyme-linked immunosorbent assay technique specific igg and igg helicobacter pylori antibodies were determined in serum obtained at the start of therapy and at the most recent visit. at the start of therapy 26 patients (51%) had evidence of h. pylori infection, as demonstrated by increased igg and iga antibody levels ... | 1993 | 8284634 |
| does antral distension inhibit gastric acid secretion or stimulate bicarbonate secretion in 'healthy' subjects? | the effects of a 150-ml antral balloon distension on pentagastrin-stimulated gastric acid secretion and bicarbonate secretion were studied in nine healthy subjects and eight duodenal ulcer (du) patients. the gastric secretions were simultaneously measured, using a luminal perfusion and ph/pco2 measurements. two of the healthy subjects and six of the du patients were positive for helicobacter pylori. when h. pylori-positive and -negative subjects were compared, basal gastric acid and bicarbonate ... | 1993 | 8284638 |
| [nodular antritis and helicobacter pylori infection in children]. | we have studied 115 patients infected with helicobacter pylori (hp). endoscopic nodular antritis and histologic lymphonodular hyperplasia was noted. the frequency of nodular antritis was compared between the 115 hp patients and a hp-negative age-matched control group. nodular antritis was observed in 70.4% of the hp-positive patients and 11.3% of the hp-negative group (p <0.001). the specificity of nodular antritis was 86.1%. a significant association was found between the existence of nodular a ... | 1993 | 8285457 |
| helicobacter pylori infection, cigarette smoking and alcohol consumption. a histological and clinical study on 286 subjects. | helicobacter pylori (hp) is connected with active/chronic gastritis, gastric gastric and duodenal ulcer. it is not known whether exogenous factors are involved in hp infection. the aim of this prospective study, performed on 286 consecutive subjects undergoing upper gastrointestinal endoscopy, was to evaluate the influence of smoking and alcohol consumption on hp infection. for each patient the following parameters were taken into account: sex, age, smoking (no, < 10, > 10 cig/day) and alcohol ( ... | 1993 | 8286775 |
| gastrointestinal infection in children. | infections of the gastrointestinal tract remain an important cause of childhood morbidity and mortality worldwide. a number of pertinent articles have appeared in the past year, advancing our understanding of 1) helicobacter pylori-induced gastroduodenal disease, 2) escherichia coli o157:h7-mediated diarrhea, and 3) newer gastrointestinal parasites that cause diarrhea. these are the topics of review. | 1993 | 8287081 |
| effect of helicobacter pylori colonisation on gastric mucosal eicosanoid synthesis in patients taking non-steroidal anti-inflammatory drugs. | colonisation with helicobacter pylori may influence susceptibility to gastroduodenal injury and ulceration in patients taking non-steroidal anti-inflammatory drugs (nsaids). the aim of this study was to determine if helicobacter pylori colonisation altered eicosanoid synthesis by gastric mucosa in these patients. sixty five patients with long-standing nsaid intake and 23 control subjects underwent endoscopy. in vitro gastric antral biopsies were stimulated by vortex mixing and eicosanoid measure ... | 1993 | 8314505 |
| influence of helicobacter pylori, sex, and age on serum gastrin and pepsinogen concentrations in subjects without symptoms and patients with duodenal ulcers. | the relation between helicobacter pylori (h pylori) infection and fasting gastrin and pepsinogen-i and -ii concentrations was evaluated in 278 volunteers without symptoms and the results were compared with the values obtained in 35 patients with duodenal ulcers. h pylori infection was determined with the 13c-urea breath test in subjects without symptoms and with endoscopy, biopsy (histology and culture), and quick urease test (clo-test) in patients with duodenal ulcers. gastrin and pepsinogen-i ... | 1993 | 8314506 |
| helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17. | helicobacter pylori infection increases the serum concentration of gastrin, and this may be one of the mechanisms by which it predisposes to duodenal ulceration. different forms of circulating gastrin were studied both basally and postprandially in 13 duodenal ulcer patients before and one month after eradication of h pylori. three antisera that are specific for particular regions of the gastrin molecules were used. gel chromatography indicated that > 90% of the circulating gastrin consisted of ... | 1993 | 8314507 |
| a study of the pathogenesis of helicobacter pylori negative chronic duodenal ulceration. | in the past five years 12 patients have been identified presenting with chronic duodenal ulcer (du) disease and with no evidence of current or recent helicobacter pylori (h pylori) infection. four of them were taking regular non-steroidal anti inflammatory agents, one was subsequently found to have crohn's disease of the duodenum, and one to have the zollinger-ellison syndrome. the remaining six patients with idiopathic du disease were remarkable for their absence of the a1 blood antigen gene. d ... | 1993 | 8314508 |
| diagnosis of helicobacter pylori infection by using pyloriset eia-g and eia-a for detection of serum immunoglobulin g (igg) and iga antibodies. | we evaluated the performance of new enzyme immunoassay (eia) kits (pyloriset; orion corporation, orion diagnostica, espoo, finland) for the detection of immunoglobulin g (igg) and iga antibodies to helicobacter pylori in serum. serum samples from 195 patients with upper abdominal complaints were collected. biopsy specimens of the gastric mucosae were taken for histological analysis and bacterial culture. the sensitivity, specificity, and positive and negative predictive values, and efficacy of t ... | 1993 | 8314985 |
| [physiopathology, diagnosis and therapy of stomach diseases]. | 1993 | 8315334 | |
| [helicobacter pylori infections]. | 1993 | 8315343 | |
| gastroenterology. | 1993 | 8315733 | |
| duodenal ulcer is a multifactorial disorder--the role of pepsinogen i. | serum pepsinogen i (pgi) levels were measured in 231 duodenal ulcer (du) patients and 100 sex- and age-comparable healthy controls. significantly higher mean serum pgi levels were found in du patients than in controls (124.7 +/- 3.4 ng/ml v. 92.9 +/- 2.3 ng/ml; p < 0.001) (mean +/- se). these levels were higher in male du patients than in female du patients (128.5 +/- 3.9 ng/ml v. 107.4 +/- 6.4 ng/ml; p < 0.05). smoking was associated with elevated serum pgi levels in du patients (145.3 +/- 5.1 ... | 1993 | 8316925 |
| hyperplastic polyposis and diffuse carcinoma of the stomach. a study of a family. | the authors previously described a large pedigree with familial gastric polyposis and a high incidence of gastric cancer and demonstrated the autosomal dominant pattern of inheritance. the current study described the histologic and immunohistologic features of the lesions in an attempt to clarify the mechanisms underlying gastric carcinogenesis in this family. | 1993 | 8319165 |
| the time trend and age-period-cohort effects on incidence of adenocarcinoma of the stomach in connecticut from 1955-1989. | adenocarcinoma of the gastric cardia has been be increasing in connecticut, and the risk factors responsible for the increasing incidence are unknown. this study examined the incidence pattern of adenocarcinoma of the gastric cardia and distal stomach in connecticut during the past decades and identified components of birth cohort, period, and age as determinants of the observed time trends by regression modeling. | 1993 | 8319166 |
| measurement of urea and ammonium concentrations in gastric juice. | to study the effect of known interference in the measurement of urea and ammonium concentrations in samples of gastric juice. | 1993 | 8320328 |
| treatment and long-term follow-up of helicobacter pylori-associated duodenal ulcer disease in children. | in a 7-year period, 33 children had endoscopically documented duodenal ulcer disease. of the 33 children, 29 had helicobacter pylori antral gastritis. all children with h. pylori-associated duodenal ulcer disease were treated with antibiotics but no h2-receptor blocking agents. for the first 3 years of the study, initial treatment was with bismuth subsalicylate or amoxicillin for 6 weeks. for the latter 4 years, therapy with both bismuth subsalicylate and amoxicillin for 6 weeks was used initial ... | 1993 | 8320625 |
| imprint cytology--a cheap, rapid and effective method for diagnosing helicobacter pylori. | to compare the efficacy of imprint cytology, histology and clo-test (for biopsy urease) in detecting helicobacter pylori infection, antral biopsies were taken from 239 patients undergoing upper gastrointestinal endoscopy. both imprint cytology and histology showed the presence of h. pylori in 215 (90%) patients. the sensitivity and specificity of imprint cytology vis-à-vis histology was noted to be 100%. the clo-test was performed in 165 patients and was positive in 130 (79%) patients. the sensi ... | 1993 | 8321793 |
| role of helicobacter pylori infection and duodenogastric reflux in the pathogenesis of alkaline reflux gastritis after gastric operations. | in patients undergoing gastric operations, we studied the relationship between data suggesting alkaline reflux gastritis (symptoms, endoscopic alterations and histologic lesions) and two factors that produce chronic gastritis (helicobacter pylori and duodenogastric reflux). of 225 patients who underwent operations for gastroduodenal gastric ulcer at our general surgery unit between 1980 and 1982, 63 agreed to undergo endoscopy and biopsies. of these 63 patients, 38 agreed to a test to quantify d ... | 1993 | 8322136 |
| giant fold gastritis--a special form of helicobacter pylori associated gastritis. | we investigated the question as to how frequently helicobacter pylori gastritis is present in cases of endoscopically detected giant folds of the corpus and fundic mucosa, and whether this gastritis differs from helicobacter pylori associated gastritis with no giant folds. biopsy material obtained from 138 patients with giant folds (sex ratio: 1.0 men: 105 women; average age 61.0 years) was evaluated histologically and compared with that obtained from 1,196 patients with h. pylori associated gas ... | 1993 | 8322475 |
| [helicobacter pylori associated gastritis and primary stomach lymphoma]. | 1993 | 8322481 | |
| protection of germ-free mice from infection by helicobacter felis after active oral or passive iga immunization. | helicobacter pylori infection of human gastric epithelium has been associated with gastritis, ulcers and gastric cancers. in an h. felis, germ-free mouse model of infection, oral immunization with bacterial antigens plus cholera toxin resulted in elevated serum, gastric and intestinal anti-h. felis antibody titres and protection from acute infection. mice given monoclonal iga anti-h. felis antibody at the time of initial challenge were also protected from infection. these results demonstrate tha ... | 1993 | 8322486 |
| helicobacter pylori: a cause of chronic abdominal pain in children. | approximately one in ten children are seen by a health care professional for a complaint of chronic recurrent abdominal pain. in most cases these complaints are non-organic. organic causes of abdominal pain may include gastroesophageal reflux, peptic ulcer disease, gallbladder, pancreatic or kidney disease. in addition, infection of the gastric antrum with helicobacter pylori is now included in the differential diagnosis of chronic abdominal pain in children. h. pylori are "s" or "c" shaped, gra ... | 1993 | 8323993 |
| rapid test for detection of antibodies to helicobacter pylori. | 1993 | 8324158 | |
| the inflammatory response of the gastric mucosa of mice experimentally infected with "gastrospirillum suis". | to establish an experimental model to study gastric spiral non-cultivable bacteria, 30 4-week-old female cfw (lob) mice were inoculated with porcine gastric mucus containing "gastrospirillum suis" and 25 mice were inoculated with mucus without "g. suis". mice were examined 3, 7, 14, 21, 28 and 60 days after inoculation. fragments from the membranous, oxyntic and antral gastric mucosa and from the duodenal mucosa were obtained for histological and microbiological analysis. tightly spiralled bacte ... | 1993 | 8326514 |
| [oral triple therapy for eradication of helicobacter pylori in duodenal ulcer disease]. | 25 patients with helicobacter pylori-associated active duodenal ulcer disease (bleeding: n = 5, penetrating: n = 1, stenosis of the bulb: n = 4, frequent ulcer relapse: n = 18) were treated with 3 x 600 mg bismuth subsalicylate (bss), 3 x 400 mg metronidazole and 3 x 500 mg tetracycline in addition to 300 mg ranitidine. 23 out of 25 patients (92%) proved to be helicobacter pylori-negative four weeks after cessation of study medication as judged from negative urease test, specific culture and his ... | 1993 | 8326916 |
| the us temporal and geographic variations of diseases related to helicobacter pylori. | if helicobacter pylori plays an important role in the occurrence of three distinct diseases--gastric cancer, gastric ulcer, and duodenal ulcer--their individual epidemiologic behaviors should show a resemblance to one common pattern. | 1993 | 8328594 |