Publications

TitleAbstractYear(sorted ascending)
Filter
PMID
Filter
detection of sequence variation in pcr-amplified fragments of omp2 gene from three species of the family chlamydiaceae using agarose gel electrophoresis containing bisbenzimide-peg.a simple technique providing a means for rapid genetic differentiation of chlamydial strains is described. the technique is based on a single-step sequence-specific separation of pcr-amplified dna fragments by electrophoresis in an agarose gel containing a dna ligand - bisbenzimide-peg. a hypervariable region at the 5' end of the omp2 gene of chlamydiaceae species encoding the 60-kda cysteine-rich outer membrane protein was selected as a target for pcr. the appropriate fragments were amplified f ...200010713423
seroprevalence of chlamydia pneumoniae antibodies in a young adult population sample living in verona. european community respiratory health survey (ecrhs) verona.the aim of the study was to evaluate the prevalence of antibodies to chlamydia pneumoniae in a random population sample of 369 young adults (aged 20-44 years), living in verona, italy. igg and igm titers were measured by micro-immunofluorescence. igg antibodies, greater or equal to 16, were found in 104/177 (58.8%) men and 76/192 (39.6%) women (p < 0.001). no relationship was found between igg seropositivity, age, social class, education and family size. factors positively associated with igg se ...200010697790
touchdown enzyme time release-pcr for detection and identification of chlamydia trachomatis, c. pneumoniae, and c. psittaci using the 16s and 16s-23s spacer rrna genes.three touchdown enzyme time release (tetr)-pcr assays were used to amplify different dna sequences in the variable regions of the 16s and 16s-23s spacer rrna genes specific for chlamydia trachomatis, chlamydia pneumoniae, and chlamydia psittaci as improved tests for sensitive diagnosis and rapid species differentiation. the tetr-pcr protocol used 60 cycles of amplification, which provided improved analytical sensitivity (0.004 to 0.063 inclusion-forming unit of chlamydia species per pcr). the se ...200010699002
[chlamydia, atherosclerosis, asthma and ms]. 200010701305
gender, chronic infection and myocardial infarction. 200010702035
association of chlamydia pneumoniae infection with diabetic nephropathy.we evaluated the association of chlamydia pneumoniae (cp) infection with progression of diabetic nephropathy. type 2 diabetic patients (60) were divided into two groups, those with incipient nephropathy and those with advanced nephropathy, based on the severity of diffuse glomerular lesions using gellman's criteria. type 2 (34) diabetic patients without nephropathy (normoalbuminuria) and 59 nondiabetics served as control groups. serum igg-antibody against cp was measured using elisa. cp antibody ...200010660220
a novel superfamily of predicted cysteine proteases from eukaryotes, viruses and chlamydia pneumoniae. 200010664582
chlamydia pneumoniae-induced transactivation of the major immediate early promoter of cytomegalovirus: potential synergy of infectious agents in the pathogenesis of atherosclerosis.both cytomegalovirus (cmv) and chlamydia pneumoniae have been associated with atherosclerosis. cmv is believed to exist in host tissues in a latent state with periodic reactivation. this study was designed to determine whether c. pneumoniae infection stimulates the expression of cmv genes. transactivation of the cmv major immediate early promoter (miep) is essential for viral gene expression and viral replication. hela cells were transfected with a construct containing a reporter gene (chloramph ...200010669378
characteristics and prognosis of myocardial infarction in patients with normal coronary arteries.myocardial infarction with angiographically normal coronary arteries (minc) is a life-threatening event with many open questions for physicians and patients. there are little data concerning the prognosis for patients with minc.200010669671
community-acquired chlamydia pneumoniae pneumonia. 200010669723
lack of correlation between chlamydia pneumoniae antibody titers and adult-onset asthma. 200010669864
genome sequences of chlamydia trachomatis mopn and chlamydia pneumoniae ar39.the genome sequences of chlamydia trachomatis mouse pneumonitis (mopn) strain nigg (1 069 412 nt) and chlamydia pneumoniae strain ar39 (1 229 853 nt) were determined using a random shotgun strategy. the mopn genome exhibited a general conservation of gene order and content with the previously sequenced c.trachomatis serovar d. differences between c.trachomatis strains were focused on an approximately 50 kb 'plasticity zone' near the termination origins. in this region mopn contained three copies ...200010684935
atherosclerosis, inflammation, and infection.in recent years, it has been shown that inflammation plays an important role in the pathogenesis of atherosclerosis. activated macrophages, t lymphocytes, and mast cells are present in atherosclerotic plaques, which has led to the notion that the inflammatory response is an immune-mediated process. complicated lesions, moreover, appear to be associated with an increase in the amount of the inflammatory response and in these patients, increased levels of acute phase proteins are present. the appr ...200010685058
chronic infection and coronary artery disease.on a variety of fronts, chronic infection has been found to be significantly associated with the development of atherosclerosis and the clinical complications of unstable angina, myocardial infarction, and stroke. for the most part, these are still just associations. specific causative relationships on par with that determined between h. pylori and peptic ulcer disease have not yet been established. potential mechanisms whereby chronic infections may play a role in atherogenesis are myriad. in t ...200010685131
is there a role for antibiotics in the treatment of asthma?: involvement of atypical organisms.emerging evidence suggests an association between some asthma and pulmonary infection by the atypical organisms chlamydia pneumoniae and mycoplasma pneumoniae, but a causal role for infection remains unproven and controversial. most acute exacerbations of asthma are triggered by acute infections that are due to viral respiratory pathogens, not to bacteria or atypical organisms. administration of antibiotics for acute exacerbations of asthma has been shown to be ineffective. most evidence linking ...200018034578
chlamydia pneumoniae antibodies and inflammatory reaction in patients with ischemic heart disease.we studied the relationship between chlamydia pneumoniae antibodies, c-reactive protein (crp) and interleukine 8 (il-8) in 87 patients with ischemic heart disease: 29 patients with acute myocardial infarction, 18 patients with unstable angina pectoris and 40 patients with stable effort angina. we determined in all patients igg and iga antibodies to chlamydia pneumoniae, crp and il-8. species specific antibodies to chlamydia pneumoniae (igg and iga) were detected by indirect elisa technique (savy ...200015529571
epidemiology and bacteriology of bacterial pneumonias.an understanding of the epidemiology and bacteriology of pneumonia in childhood is frustrated by the difficulties in making an aetiological diagnosis in young children. incidence figures for community-acquired pneumonia are derived from the 1970s and 1980s and suggest that the incidence is higher in young children than in older children: approximately 40/1000/year <5 years of age and 15/1000/year aged 5-14 years. certain pathogens are associated with pneumonia in different age groups, mycoplasma ...200016263435
the antibiotic treatment of severe community-acquired pneumonia admitted to the critical care unit.community-acquired pneumonias (cap) are still caused by streptococcus pneumoniae, hemophilus influenzae, or moraxella catarrhalis. legionella and chlamydia pneumoniae have been defined as important atypical pathogens causing cap. klebsiella causes cap primarily in patients with chronic alcoholism or in chronic care facilities. normal hosts do not present with "unusual pathogens'' e.g., staphylococcus aureus or pseudomonas aeruginosa. the clinical severity of a bacterial pneumonia has important p ...200016088719
chlamydia pneumoniae pneumonia.chlamydia pneumoniae is a common cause of community-acquired pneumonia. at present there is no "gold'' standard for diagnosis and there is no easily accessible means of rapid diagnosis available. the best indication of acute c. pneumoniae infection is a fourfold rise in antibody titer, accompanying a positive polymerase chain reaction or culture. c. pneumoniae is usually associated with nonsevere clinical manifestations but the features will vary depending upon the occurrence as primary or reinf ...200016088739
association of myocardial infarction with mononuclear cell expression of the cytomegalovirus chemokine receptor us28 in patients with niddm.infectious agents have been linked to atherosclerosis and its acute manifestations; however, little is known about their influence in the context of established risk factors.200120428272
acepromazine modulates cell differentiation: in vitro experiments on monocytes stimulated by chlamydia pneumoniae toxins. 200128404253
community-acquired pneumonia: role of atypical organisms.m. pneumoniae infection occurs world-wide and is the most common cause of community-acquired pneumonia (cap) in the 5 to 20 year-old age group. the most reliable diagnostic test is enzyme immunoassay that allows immunoglobulin (ig)g and igm titration and presents 92% sensitivity and 95% specificity on paired samples. potentially active drugs are tetracyclines, macrolides, ketolides, lincosamides, streptogamines, chloramphenicol, and fluoroquinolones. the incidence of legionella infection, in spi ...200111980285
the relationship between infection, inflammation, and cardiovascular disease: an overview.atherosclerotic plaques were likened histologically to healing inflammatory lesions by russell ross, who proposed a "response to injury" hypothesis for their formation. more recently, intraplaque inflammation has been postulated to play a role in thinning of the fibrous cap, plaque rupture, and superadded thrombosis. potential causes for vascular injury include mechanical stress, smoke exposure, hypercholesterolemia, hyperhomocysteinemia, and chronic infection (direct, or indirect). blood levels ...200111887452
[atherosclerosis--search for a new entity].atherogenesis is a disease of middle-sized and large caliber blood vessels that can be divided into three major phases. the initial lesions of early atherosclerosis are characterized by the adhesion and subendothelial emigration of blood-borne monocytes, which differentiate into macrophages and provide the morphological basis for the formation of foam cells and fatty streak lesions. these lesions are found in most children and teenagers in industrialized nations. the next key event in atherogene ...200111894390
[chlamydia pneumoniae infection and arteriosclerosis]. 200111917864
respiratory syncytial virus and chlamydia are not detectable by pcr in ongoing vernal keratoconjunctivitis.respiratory syncytial virus (rsv) and chlamydial infection may be pathogenetic factors in allergic diseases, perhaps also in ocular allergy. we analyzed the presence of rsv and chlamydial nucleic acids using reverse transcription (rt)-pcr and pcr, respectively, in conjunctival biopsies from patients with vernal keratoconjunctivitis (vkc) in order to determine whether these agents play a role in the maintenance of the disease. all biopsy samples were negative for both rsv (n = 15 for vkc and n = ...200111935435
infection and the etiology and pathogenesis of multiple sclerosis.multiple sclerosis (ms) currently defies clinical and scientific definitions, and carries a prognosis that remains practically unchanged despite many years of intensive research. although the prevailing dogma is that ms is an immune-mediated condition, it fulfills none of the criteria of an autoimmune disease. on the other hand, there is enough significant data to suggest that infectious agents(s) could be involved in either direct damage to the white matter or induce inflammatory responses that ...200111898529
[the relation between chlamydia pneumoniae infection and abdominal aortic aneurysm].the aim of our study was to evaluate the frequency of c. pneumoniae infection in abdominal aortic aneurysm (aaa) patients by measuring c. pneumoniae specific serum igg, igm and iga levels and the activation of their immune system by measuring the concentrations of il-10, il-12, ifn-gamma and tnf-alpha in patients' serum. microimmunofluorescence method was applied to evaluate the level of anti-c. pneumoniae igg, iga and igm. the concentrations of cytokines were evaluated using elisa method. serol ...200111899845
chlamydia pneumoniae and chronic skin wounds: a focused review.the genus, chlamydophilia, as obligate intracellular pathogens, induce chronic scarring in humans. chlamydia pneumoniae, a common cause of pneumonia, infects endothelial cells and circulating macrophages. evidence that c. pneumoniae is an opportunistic pathogen in chronic skin ulcers and other inflammatory skin conditions analogous to its role in atherosclerosis is reviewed.200111924834
chronic infections and atherosclerosis.the established risk factors for atherosclerosis such as hypertension, smoking, diabetes mellitus, hyperlipidemia, and hyperhomocysteinemia do not explain clinical and epidemiological features of coronary heart disease (chd). the role of infectious disease as a chd risk factor may partly explain these features. chronic infection with various microorganisms, particularly, chlamydia pneumoniae, cytomegalovirus (cmv) and helicobacter pylori may play a role in etiological factors, linking inflammati ...200112002906
rapid detection of chlamydia pneumoniae dna in peripheral blood mononuclear cells of coronary artery disease patients by real-time fluorescence pcr.several recent reports including serological, pathological and animal studies have associated chlamydia pneumoniae with coronary artery disease (cad). in order to establish whether chronic c. pneumoniae infection is linked to coronary artery disease, clinical intervention trials may be needed. however, to detect eligible patients with persistent infection, a reliable diagnostic marker must be developed for identifying cases and assessing efficacy of antichlamydial therapy. moreover, the prevalen ...200112002907
roxithromycin in prevention of acute coronary syndrome associated with chlamydia pneumoniae infection: a randomized placebo controlled trial.the role of chlamydia pneumoniae infection in precipitating acute coronary syndrome (acs) is unclear. some studies have indicated that intervention with macrolide antibiotics might reduce coronary events in patients with acs. a double blind, randomized, placebo-control trial was conducted on 84 acs patients. patients were randomized to 30 days of treatment with roxithromycin (150 mg, twice daily) or matching placebo. the follow-up period was 90 days, and the primary clinical end point included c ...200112002908
absence of chlamydia pneumoniae in surgical specimens of coronary and carotid arteries by polymerase chain reaction.several recent articles indicate the renewed interest that chlamydia pneumoniae is associated with and contributes to arterial diseases. associations have been established for coronary arteries, carotid arteries and abdominal aortic aneurysms by serological studies, immunofluorescence and dna-specific testing. the purpose of this study was to determine the presence of c. pneumoniae in coronary artery plaques, carotid artery plaques and old vein grafts that were harvested at the time of surgery.200112160763
non-specific interstitial pneumonia and chlamydia pneumoniae infection.recently, the clinical features of non-specific interstitial pneumonia (nsip) have been described. we hypothesize that recurrent infection caused by chlamydia pneumoniae may play a role in the pathogenesis of nsip. to prove this, we quantified serum iga and igg antibodies against c. pneumoniae using the enzyme linked-immunosorbent assay kit. the study included 15 patients diagnosed with nsip, 20 patients with chronic obstructive pulmonary diseases (copd) as disease group, and 27 control subjects ...200111862004
[chlamydia pneumoniae and myocardial infarct? (serologic study)].at disposal for tests were 156 blood sera collected from patients with acute myocardial infarction (ami samples) and 67 blood sera collected from control persons. the sera were tested by the following reactions: complement fixation test (cft) with genus-specific antigen (c. psittaci, bioveta, ivanovice na hané), elisa in the immunoglobulin classes igg and iga using the momp (vircell, spain) and lps (medac, hamburg, brd) chlamydia pneumoniae (c. p.) antigens, and indirect immunofluorescence test ...200111826549
detection of chlamydophila pneumoniae dna in peripheral blood mononuclear cells of blood donors in the north-east of italy.recent studies have implicated chlamydia pneumoniae (now chlamydophila pneumoniae) in the pathogenesis of atherosclerosis and demonstrated its presence within human peripheral blood mononuclear cells (pbmcs). in this study the presence of c. pneumoniae dna was assessed, using nested pcr, in pbmcs from 169 active blood donors as a function of age, of specific antibodies and c-reactive protein. the results obtained demonstrated a high degree of global positivity (46.15%), which was higher in femal ...200111827203
[new infectious diseases]. 200111820173
[chlamydia pneumoniae--chronic infection and atherosclerosis].recent evidence suggests that common chronic infections may contribute to the initiation and/or progression of atherosclerosis. infection of the vascular wall with chlamydia pneumoniae, a gramnegative bacterium, has been linked with coronary heart disease, myocardial infarction and stroke in epidemiological studies and in pathological studies using immunohistochemistry and electron microscopy. in addition striking evidence for an active role of chlamydia pneumoniae in atherogenesis has been prov ...200111820175
[infection hypothesis of coronary heart disease].it is well accepted that coronary artery disease is linked to an inflammatory process. it is unproven however whether either infectious agents may cause or accelerate coronary artery disease or the inflammatory process is due to metabolic or toxic effects. among the possible infectious agents chlamydia pneumoniae is the most likely bacterium involved in atherosclerosis. the arguments in favour of chlamydia pneumoniae originate from seroepidemiologic studies and from detection and isolation of ba ...200111820176
risk factors of wheeze and allergy after lower respiratory tract infections during early childhood.lower respiratory tract infections (lris) during early childhood can lead to bronchial hyperreactivity or recurrent obstructive bronchitis. the role of lris in the pathogenesis of allergic diseases such as allergic rhinoconjunctivitis, atopic eczema, and bronchial asthma is less clear. the aim of this retrospective study was to determine the incidence of subsequent wheezing and atopy, and the known risk factors for allergic sensitization in 74 children hospitalized for acute lris of various etio ...200111825005
high sensitivity immunoassays for c-reactive protein: promises and pitfalls.c-reactive protein (crp) has historically been measured in the clinical laboratory for the detection and monitoring of occult infection and inflammation, using immunoturbidimetric or immunonephelometric techniques. the recent commercial availability of automated high-sensitivity assays has enabled investigators to measure crp at levels previously unattainable on a routine basis and to explore its clinical utility in apparently healthy individuals. crp concentrations increased above the individua ...200111831635
isolated 6th nerve palsy in a child associated with asymptomatic chlamydia pneumoniae infection and elevated anti-gq1b antibody. 200111421427
chlamydia pneumoniae and atherosclerosis.based on seroepidemiological studies, chlamydia pneumoniae has been suspected to play a role in atherosclerosis. the organism was searched for in atherosclerotic lesions by electron microscopy, immunohistochemistry, culture and pcr. it appears from published data and our own investigations that contrary to what could be expected, the sensitivity of pcr is much lower than that of the 3 other techniques. moreover, pcr results are frequently conflicting. we therefore propose to interpret the result ...200111813502
[genome analysis of pathogenic bacteria]. 200111802401
[chlamydia pneumoniae infection in patients with chronic obstructive pulmonary disease].to investigate the association of chlamydia pneumoniae infection with chronic obstructive pulmonary disease (copd).200111802964
effect of chlamydia pneumoniae infection on coronary flow reserve and intimal hyperplasia after stent implantation in patients with angina pectoris.chlamydia pneumoniae (c. pneumoniae) has been detected in tissue from coronary atherosclerotic vascular lesions and may be involved in the pathogenesis of atherosclerosis. however, the effect of prior c. pneumoniae infection on coronary intimal hyperplasia after stent implantation and on coronary microvascular function is unknown.200111806088
[clinical significance of interaction between chlamydia infection (chlamydia pneumoniae) and free radical processes during ischemic heart disease].to determine occurrence and activity of chlamydial infection (ci) as well as activity of free radical processes in clinical course of different forms of ischemic heart disease.200111806203
analysis of the serological response to chlamydia pneumoniae in patients with ischemic heart disease by recombinant momp-elisa.to investigate the humoral immune response to the major outer membrane protein (momp) of chlamydia pneumoniae, a fusion protein, thioredoxin-(his)6-momp (rmomp) was produced in escherichia coli and purified; this served as an antigen to establish an enzyme-linked immunosorbent assay (elisa). specific igg and iga antibodies against rmomp were determined in sera from patients with ischemic heart disease. the findings were compared with those obtained by elisa using the outer membrane protein compl ...200111810581
macrolide treatment after coronary stent placement. 200111784661
antibodies anti-chlamydia pneumoniae and anti-mycoplasma pneumoniae in patients with negative serology for hantavirus. retrospective study.the seroprevalence of chlamydia pneumoniae and mycoplasma pneumoniae in hantavirus seronegative patients, who had symptoms and signs compatible with pneumonia was established. for this purpose we used the indirect fluorescent antibody test. titers > or = 1:16 for c. pneumoniae and m. pneumoniae were found in 8.6% and 17.1% of the serum, respectively, showing evidence of recent or current infection.200111784935
chlamydia trachomatis and mycobacterium tuberculosis lung infection in an hiv-positive homosexual man.a 31-year-old homosexual man, who was human immunodeficiency virus (hiv)-positive was admitted for fever and cough. chest computed tomography (ct) revealed the presence of diffuse interstitial reticular nodulation, and brain nuclear magnetic resonance imaging showed the presence of nodular frontal lesions. microscopic examination of sputum and other body fluids showed the presence of acid-fast bacilli and culture-only growth mycobacterium tuberculosis. serology for respiratory tract pathogens wa ...200111788074
constant relative rate of protein evolution and detection of functional diversification among bacterial, archaeal and eukaryotic proteins.detection of changes in a protein's evolutionary rate may reveal cases of change in that protein's function. we developed and implemented a simple relative rates test in an attempt to assess the rate constancy of protein evolution and to detect cases of functional diversification between orthologous proteins. the test was performed on clusters of orthologous protein sequences from complete bacterial genomes (chlamydia trachomatis, c. muridarum and chlamydophila pneumoniae), complete archaeal gen ...200111790256
chronic infections and atherosclerosis.the inability of traditional risk factors such as hypercholesterolemia, hypertension, and smoking to explain the incidence of atherosclerosis (at) in about 50% of the cases prompted a search for additional putative risk factors involved in the development of the disease. infectious agents have long been suspected to initiate/contribute to the process of at. it has also been suggested that inflammation, either related to infectious agents or independent from infection, may mediate the atherogenic ...200111791347
role of infection in alzheimer's disease.alzheimer's disease (ad) is a chronic condition in which inflammation has been shown to contribute to neurodegeneration. current thinking suggests that deposition of beta-amyloid in the brain promotes inflammation resulting in neuronal damage/death. alternatively, our data suggest that chronic inflammation observed in late-onset sporadic ad may be stimulated by infection with the obligate, intracellular bacterium, chlamydia pneumoniae. our results indicate that c. pneumoniae is found in high fre ...200111794745
chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls.chlamydia pneumoniae infection is a common event in neurological patients and recovery of c. pneumoniae dna in the cerebrospinal fluids (csf) of multiple sclerosis (ms) patients could represent an epiphenomenon. we assessed the relevance of c. pneumoniae infection in 62 csf samples from 32 ms patients and 30 neurological controls by means of pcr, immunofluorescence microscopy, enzyme-linked fluorescence and antibody detection. multiple sclerosis (9.3%) and neurological controls (13.3) had simila ...200111795458
emerging role of mycoplasma pneumoniae and chlamydia pneumoniae in paediatric respiratory-tract infections.increased use of specialised diagnostic techniques over the past 10 years has allowed considerable new information to be obtained concerning mycoplasma pneumoniae and chlamydia pneumoniae infections. in children, these pathogens seem to have a more important role in causing respiratory-tract infections than previously thought; they have been associated with wheezing, and they are also frequent in children aged under 5 years. contrary to original belief, no clinical, laboratory, or radiological f ...200111871806
an association between chronic infection with chlamydia pneumoniae and lung cancer. a prospective 2-year study.this study assesses a possible relationship between chronic chlamydia pneumoniae (cpn) infection and lung cancer (lc). a total of 210 consecutive patients (136 m, 74 f) were diagnosed with lc during a 2-year period. blood was obtained from 128 m and 70 f patients for cpn serology. repeat blood specimens were taken after 3 months. throat specimens for cpn dna analysis by pcr were taken from 110/136 m and 63/74 f seventy-four cytobrush specimens were taken and also analyzed by polymerase chain rea ...200111878709
species specific chlamydiae antibodies in voluntary blood donors of delhi.different species of genus chlamydia have been associated with ocular, genitourinary and respiratory infections, and coronary artery disease. since the majority of these infections remain asymptomatic or subclinical, antibodies may be present in apparently healthy individuals, and the determination of species specific chlamydia antibodies in a healthy population may reflect exposure. we therefore screened the sera of healthy blood donors for species specific chlamydia antibodies by microimmunofl ...200112025256
[biochemical risk factor for atherosclerosis in young men. preliminary report].atherosclerotic damage of cardiovascular system, including kidneys, is an increasing problem not only in the modern cardiology but also in nephrology and dialysotherapy. the purpose of our study was to evaluate the frequency of particular biochemical risk factors for atherosclerosis (rffa) in young men being over-pressed with psychological stress because of decisive character of their professional job. there were 68 men in mean age 33.3 +/- 7.4 years, being employed in the state administration f ...200112026514
chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation.an early component of atherogenesis is abnormal vascular smooth muscle cell (vsmc) proliferation. the presence of chlamydia pneumoniae in many atherosclerotic lesions raises the possibility that this organism plays a causal role in atherogenesis. in this study, c pneumoniae elementary bodies (ebs) rapidly activated p44/p42 mitogen-activated protein kinases (mapks) and stimulated proliferation of vsmcs in vitro. exposure of vsmcs derived from human saphenous vein to c pneumoniae ebs (3x10(7) incl ...200111485974
host immune response to chlamydia pneumoniae heat shock protein 60 is associated with asthma.chlamydia pneumoniae infection has been associated with asthma. it has also been suggested that heat shock protein 60 (hsp60) belonging to a class of highly conserved proteins may play a role in the pathogenesis of chlamydial infections. the purpose was to study whether the host immune response to c. pneumoniae hsp60 is associated with asthma and decreased pulmonary function. an enzyme immunoassay was used to measure immunoglobulin-(ig)a and igg antibodies against recombinant c. pneumoniae hsp60 ...200111491147
nonsevere community-acquired pneumonia: correlation between cause and severity or comorbidity.community-acquired pneumonia frequently constitutes a nonsevere infection manageable at home. however, for these low-risk episodes, the epidemiological features have not been carefully analyzed.200111493128
azithromycin chemoprophylaxis. 200111494171
[a case presenting severe respiratory failure with high antibody titers to chlamydia pneumoniae]."hitazyme c. pneumoniae" is a diagnostic reagent that has been recently developed by adopting an elisa method for detection of anti-chlamydia pneumoniae (c. pneumoniae) antibodies. a case presenting bilateral interstitial opacities and severe respiratory failure with high titers of "hitazyme c. pneumoniae" was described. sputum, blood, serological, and bronchoalveolar lavage examinations failed to reveal other etiology to explain his severe respiratory illness. clinicians should be aware that c. ...200111494568
discovering the dynamics of microbial genomes. 200111494770
indicators of infection with chlamydia pneumoniae are associated with expansion of abdominal aortic aneurysms.chlamydia pneumoniae has been shown to be associated with atherosclerosis, myocardial infarction, and abdominal aortic aneurysms (aaas). the possible association between aaa expansion and c pneumoniae infection was therefore assessed.200111496270
chlamydia pneumoniae infection accelerates hyperlipidemia induced atherosclerotic lesion development in c57bl/6j mice.considerable evidence of an association between chlamydia pneumoniae infections and cardiovascular disease has emerged. animal models using genetically altered mice and hypercholesterolemic rabbits have shown a pathogenic role of c. pneumoniae in accelerating atherosclerotic plaque development. in the present study, we evaluated the effect of chronic c. pneumoniae infection on atherosclerosis in c57bl/6j mice, fed either a regular chow diet or a high fat, high cholesterol diet. infected animals ...200111500169
demonstration of chlamydia pneumoniae in atherosclerotic arteries from various vascular regions.chlamydia pneumoniae (cp) has been reported to be a pathogenic agent in the mechanism leading to atherosclerosis. the majority of available data is focused mainly on coronary artery disease whereas the distribution of cp in different areas, associated with atherosclerotic disorders, has not been completely clarified. in this study we investigated the presence of cp in atheromasic plaques from five different vascular areas (basilary artery, coronary artery, thoracic aorta, abdominal aorta, renal ...200111500176
chlamydia pneumoniae expresses genes required for dna replication but not cytokinesis during persistent infection of hep-2 cells.chlamydia pneumoniae causes community-acquired pneumonia and is associated with several chronic diseases, including asthma and atherosclerosis. the intracellular growth rate of c. pneumoniae slows dramatically during chronic infection, and such persistence leads to attenuated production of new elementary bodies, appearance of morphologically aberrant reticulate bodies, and altered expression of several chlamydial genes. we used an in vitro system to further characterize persistent c. pneumoniae ...200111500413
prevalence of chlamydia pneumoniae in acute respiratory tract infection and detection of anti-chlamydia pneumoniae-specific ige in japanese children with reactive airway disease.we examined the prevalence of chlamydia pneumoniae in acute respiratory tract infection and association of c. pneumoniae infection and reactive airway disease in japanese children. four hundred eleven children with acute respiratory tract infection were enrolled in this study, and c. pneumoniae was isolated from 58 (14.1%) patients by culture. evidence of infection with c. pneumoniae was detected in 58 children with pneumonia (34.5%), bronchitis (41.4%) and upper respiratory tract infection (24. ...200111501498
frequency of occurrence of cytomegalovirus and chlamydia pneumoniae in lymphocytes of atherosclerotic patients.forty-three blood samples from atherosclerotic donors and 28 samples from normal individuals were analyzed to determine the frequency of occurrence of cytomegalovirus (cmv) and chlamydia pneumoniae dna sequences in lymphocytes of saudi arabian donors using polymerase chain reaction (pcr). in non-atherosclerotic donors, no cmv dna was detectable and only one sample was positive for c-pneumoniae dna sequences. of the 43 atherosclerotic patients, 22 were infected with cmv, 23 were infected with c-p ...200111503273
[influence of chlamydia pneumoniae and cytomegalovirus infections on prevalence and the course of coronary artery disease].chlamydia pneumoniae (c. pneumoniae) as well as cytomegalovirus (cmv) are common pathogens found in about 50% of healthy western population. many studies suggest a role of c. pneumoniae in development of coronary artery disease (cad). cmv infection is also considered to increase risk of developing of cad as well as restenosis after percutaneous coronary revascularization (pci). the aim of our study was to evaluate a possible role of c. pneumoniae and cmv infections in both cad development and co ...200111505697
chlamydial nucleic acids in synovium in osteoarthritis: what are the implications?to study whether there is evidence of bacterial dna in some osteoarthritic (oa) joint tissues, and the clinical implications of finding bacterial dna in this relatively noninflammatory disease.200111508594
[infection thesis as explanation of the higher incidence of myocardial infarction in males]. 200111512289
[diseases from chlamydia psittaci and chlamydia pneumoniae]. 200111515199
no evidence of cns infection with chlamydia pneumoniae in patients with multiple sclerosis. 200111518005
clinical analysis of community-acquired pneumonia in the elderly.to evaluate the clinical features, etiology, and outcome of patients over 65 years old hospitalized for community-acquired pneumonia.200111518106
san-pin wang, md, mph, dmsc 1920-2001. 200111518862
is chlamydia pneumoniae important in asthma? the first controlled trial of therapy leaves the question unanswered. 200111520706
trial of roxithromycin in subjects with asthma and serological evidence of infection with chlamydia pneumoniae.an association has been reported between chronic infection with chlamydia pneumoniae and the severity of asthma, and uncontrolled observations have suggested that treatment with antibiotics active against c. pneumoniae leads to an improvement in asthma control. we studied the effect of roxithromycin in subjects with asthma and immunoglobulin g (igg) antibodies to c. pneumoniae > or = 1:64 and/or iga antibodies > or = 1:16. a total of 232 subjects, from australia, new zealand, italy, or argentina ...200111520711
[demonstration of chlamydophila pneumoniae and chlamydia stress protein, hsp-60 in heart muscle tissue].there has been much attention to the association between chlamydophila pneumoniae and athrosclerosis since c. pneumoniae was demonstrated in macropharges, and vascular smooth muscle cells of atheroma tissues. there are few data demonstrating whether c. pneumoniae is present in other tissues than atherosclerotic tissues. we surveyed samples of heart tissue from 10 patients with ischemic heart disease and 10 patients with other disease by immunohistochemical staining with monoclonal antibodies aga ...200111521279
microbiological profile of telithromycin, the first ketolide antimicrobial.telithromycin, the first of the ketolide antimicrobials, has been specifically designed to provide potent activity against common and atypical/intracellular or cell-associated respiratory pathogens, including those that are resistant to beta-lactams and/or macrolide-lincosamide-streptograminb (mls(b)) antimicrobials. against gram-positive cocci, telithromycin possesses more potent activity in vitro and in vivo than the macrolides clarithromycin and azithromycin. it retains its activity against e ...200111523558
failure to detect chlamydia pneumoniae in the central nervous system of patients with ms. 200111524506
antibodies to chlamydia pneumoniae in young swedish orienteers.during 1992-93 sera from 1790 swedish elite orienteers were tested for antibodies to chlamydia pneumoniae. the reason for this was that a cluster of 16 cases of sudden unexpected cardiac death had occurred among swedish orienteers and dna from c. pneumoniae had been found in the myocarditic heart and in the lung in 1 of 2 deceased athletes in whom testing was feasible; in addition, c. pneumoniae igg was found in all 5 cases where serum was available. among the orienteers, the prevalence rates of ...200111525352
effects of interleukin-1 gene polymorphisms on the development of coronary artery disease associated with chlamydia pneumoniae infection.this study was done to elucidate the effects of interleukin (il)-1 gene polymorphisms on coronary artery disease (cad) associated with chlamydia pneumoniae (cp) infection.200111527622
seroprevalence of antibodies to microorganisms known to cause arterial and myocardial damage in patients with or without coronary stenosis.infections are assumed to play a role in coronary artery disease (cad) and cardiomyopathies. it is unknown whether the seroprevalence of antibodies to these microorganisms is higher in patients with than without cad. the seroprevalence of antibodies to bartonella henselae, borrelia burgdorferi, chlamydia pneumoniae, coxiella burnetii, helicobacter pylori, human granulocytic ehrlichia, leptospira, rickettsia conorii, and treponema pallidum was assessed prospectively in patients with exertional dy ...200111527817
sodium ion cycle in bacterial pathogens: evidence from cross-genome comparisons.analysis of the bacterial genome sequences shows that many human and animal pathogens encode primary membrane na+ pumps, na+-transporting dicarboxylate decarboxylases or na+ translocating nadh:ubiquinone oxidoreductase, and a number of na+ -dependent permeases. this indicates that these bacteria can utilize na+ as a coupling ion instead of or in addition to the h+ cycle. this capability to use a na+ cycle might be an important virulence factor for such pathogens as vibrio cholerae, neisseria men ...200111528000
randomized, placebo-controlled clinical trial of oral azithromycin prophylaxis against respiratory infections in a high-risk, young adult population.military special forces trainees undergo intense psychological and physical stressors that often lead to respiratory infection. during 1998-2000, 477 navy special forces trainees were enrolled in a double-blind trial of oral azithromycin (1 g given weekly) plus a placebo injection, compared with benzathine penicillin g (1.2 million u) plus azithromycin placebo tablets. among the 464 subjects with complete data, 44 developed acute respiratory infection (20 with pneumonia) during the 2 weeks of mo ...200111528569
in vitro activity of telithromycin, a new ketolide, against chlamydia pneumoniae.the in vitro activity of telithromycin, a new ketolide, was compared with those of roxithromycin, azithromycin, clarithromycin and erythromycin a against 20 strains of chlamydia pneumoniae. the mics and minimal chlamydiacidal concentrations of telithromycin for the 20 c. pneumoniae strains both ranged between 0.031 and 0.25 mg/l. telithromycin was twice as active as roxithromycin, azithromycin and erythromycin a, but less active than clarithromycin. these results appear to indicate that telithro ...200111533006
incidence of chlamydia pneumoniae infection in patients with coronary artery disease subjected to angioplasty or bypass surgery.seroepidemiological, pathological and animal studies suggest that chronic infection with chlamydia pneumoniae (cp) may directly impact the development or progression of atherosclerosis and coronary heart disease. the aim of the present study was to determine the seroprevalence of cp infection and markers of systemic inflammation in patients undergoing routine coronary artery examination and prior to heart revascularization.200111535948
predominant role of toll-like receptor 2 versus 4 in chlamydia pneumoniae-induced activation of dendritic cells.chlamydia pneumoniae is an obligate intracellular human pathogen causing diseases such as pneumonia, bronchitis, and pharyngitis. because of its intracellular replication, cell-mediated immune responses are needed to mediate successful defenses of the host. because dendritic cells play a central role in linking innate immunity and ag-specific cell-mediated immune responses we asked whether dendritic cells are activated upon contact with c. pneumoniae and whether known toll like receptors (tlr) a ...200111544320
chlamydia pneumoniae dna in the arterial wall of patients with peripheral vascular disease.chlamydia pneumoniae is a human respiratory pathogen that has recently been related to the genesis of symptomatic atherosclerosis. c. pneumoniae has been studied more widely in relation to coronary atherosclerosis than to peripheral arterial occlusive disease (paod). the present study aimed to retrospectively analyze the presence of c. pneumoniae dna in patients with paod.200111545479
increased cd8(+) t cells associated with chlamydia pneumoniae in symptomatic carotid plaque.the presence of chlamydia pneumoniae has been reported in carotid atheroma, but its causative effect in the activation of an atherosclerotic plaque to a prothrombotic state remains unproved. antigen- mediated activation of t lymphocytes within plaque may represent a mechanism by which infection can result in plaque conversion. the goal of the present study was to characterize the t-cell subtype profile related to the presence of c pneumoniae in patients with symptomatic versus asymptomatic carot ...200111546882
chlamydia pneumoniae in atherosclerotic middle cerebral artery.atherosclerotic middle cerebral arteries are frequent sites of thrombosis, leading to stroke. previous studies have suggested a role for chlamydia pneumoniae in the pathogenesis of atherosclerosis. however, the presence of this pathogen in atherosclerotic middle cerebral arteries has heretofore not been documented. in the present study, we analyzed atheromatous plaques from middle cerebral arteries for the presence of c pneumoniae.200111546883
newer risk factors for stroke.stroke places a tremendous burden on health resources throughout the world. improved detection and modification of risk factors could reduce the impact of this disease. important non-modifiable risk factors for ischemic stroke include age, gender, ethnicity, and heredity. modifiable risk factors include hypertension, cardiovascular disease, diabetes, hyperlipidemia, asymptomatic carotid stenosis, cigarette smoking, and alcohol abuse. data from the northern manhattan stroke study provide new insi ...200111552052
detection of chlamydia pneumoniae antigenin pbmncs of healthy blood donors.because it has been increasingly recognized that chlamydia pneumoniae may be linked to some chronic inflammatory diseases, including atherosclerosis, detection of this pathogen in blood from patients may be valuable in the diagnosis of such diseases. however, the prevalence of chlamydia in the blood of healthy donors has not yet been extensively studied.200111552067
non-detection of chlamydia species in carotid atheroma using generic primers by nested pcr in a population with a high prevalence of chlamydia pneumoniae antibody.the association of chlamydia pneumoniae with atherosclerosis is controversial. we investigated the presence of c. pneumoniae and other chlamydia spp. in atheromatous carotid artery tissue.200111553320
[presence of chlamydia pneumoniae antibodies in patients with ischemic heart disease and acute myocardial infarct]. 200111554118
possible role of chlamydia and virus infections in the development of sexual dysfunction. 200111554229
chlamydia pneumoniae, clarithromycin, and severe asthma. 200111555549
Refresh
firstprev
...11121314151617181920...
nextlast
Displaying items 1601 - 1700 of 4785