Publications

strain-dependent effect of ethanol on ventricular septal defect frequency in white leghorn chick embryos.	we have tested the potential of a single dose of ethanol (0.20 ml 50% ethanol in chick ringer's saline (crs) administered into the air sac) to produce ventricular septal defect (vsd) in three distinct commercially available strains of white leghorn chick embryo: stress-resistant dekalb delta strain, hy-vac spf type v, and hy-vac spf type l. eggs were controlled for both size and developmental stage (hamburger-hamilton stage 18-19) at time of injection. the frequency of vsd in dekalb delta embryo ...	1993	8278929
anionic sites in glomerular basement membrane of rats with serum sickness nephritis: quick-freezing and deep-etching study.	serum sickness nephritis was induced in male fisher 344/jcl rats by injecting egg albumin into the foot pads and peritoneal cavity. the alteration of anionic sites in the glomerular basement membrane (gbm) of the rats with significant proteinuria was studied with a quick-freezing and deep-etching method using polyethyleneimine as a cationic probe. in control rats, anionic sites were located around the fibrils of the lamina rara externa, which radiated perpendicularly from the lamina densa to pod ...	1993	8320129
[the incidence, etiology and clinical significance of visceral mycoses in patients with aids].	the incidence, aetiology and clinical significance of visceral mycoses in hiv-infected subjects were evaluated by a retrospective survey of the clinical and microbiological records of 237 consecutive aids patients followed-up since 1984. seventy-four patients out of 237 (31.2%) (56 males, 18 females; 55 iv drug abusers, 7 heterosexuals, 6 homobisexuals, 3 blood recipients and 3 children with congenitally-acquired hiv infection) presented 77 different episodes of visceral fungal infection as a wh ...	1993	8414130
age-related alterations in the properties of hippocampal pyramidal neurons among rat strains.	we compared age-related alterations in the electrophysiological and pharmacological properties of ca1 hippocampal pyramidal neurons in three strains of rats (sprague-dawley, fisher 344, and wistar) at 3-4 and 25-32 months of age, using the in vitro slice preparation. the most consistent age-related alterations in the properties of rat hippocampal neurons were: a decrease in membrane excitability, a decrease in the amplitude and duration of inhibitory postsynaptic potentials and a decreased sensi ...	1993	8450929
influence of the bacterial flora on collagen-induced arthritis in susceptible and resistant strains of rats.	collagen-induced arthritis is an experimental model for rheumatoid arthritis which can be elicited in susceptible strains of rats by intradermal injection of native type ii collagen. in order to investigate whether bacterial flora may alter the pathogenic response to type ii collagen, we have immunized germ-free (gf) male rats from either highly resistant fisher (f344) or highly susceptible dark agouti (da) strains. the disease was markedly enhanced in gf da as compared to conventional (cv) da r ...	1993	8453801
airway-parenchymal interdependence and bronchial responsiveness in two highly inbred rat strains.	to investigate if airway-parenchymal interdependence may account for differing bronchial responsiveness between inbred rat strains, fisher and lewis 12-wk-old male rats were anesthetized, tracheostomized, and placed in a pressure plethysmograph. functional residual capacity, total lung capacity [lung volume at transpulmonary pressure (pl) of 30 cmh2o], and specific compliance were determined and were found to be similar. rats were paralyzed and mechanically ventilated. concentration-response cur ...	1993	8458768
characterization of the promoter-regulatory region and structural organization of e1 alpha gene (bckdha) of human branched-chain alpha-keto acid dehydrogenase complex.	we have isolated genomic clones containing the complete exon 1 and the promoter-regulatory region of the e1 alpha gene (bckdha) of human branched-chain alpha-keto acid dehydrogenase complex. the cloning was achieved by amplification of a genomic library in the srb (p2) host strain that allowed the replication of nonstandard dna structures. the results of this and previous (dariush, n., fisher, c. w., cox, r. p., and chuang, d. t. (1991) febs lett. 284, 34-38) studies showed that the human e1 alp ...	1993	8463340
[buerger's disease and juvenile arteriopathy. analysis and classification based on a series of 127 cases].	the prevalence and even the existence of buerger's disease or thromboangiitis obliterans (tao) are still ill-defined. the analysis of a continuous series of 127 young patients with obstructive arterial disease of the lower limbs (mean follow-up 67.7 months, lost to follow-up 13.8%) allows the evaluation of the clinical, radiological and evolutive characteristics of the patients. the positive diagnosis of tao relies upon the four usual criteria: onset of the disease before 40, no other vascular r ...	1993	8473808
evaluation of the stereoisomers of deprenyl for amphetamine-like discriminative stimulus effects in rats.	the antiparkinsonian agent l-deprenyl, a selective monoamine oxidase (mao)-b inhibitor, is a phenylalkylamine derivative which is metabolized in part to l-methamphetamine and l-amphetamine. as the clinical use of amphetamine-like psychostimulants is limited by their potential for abuse, we evaluated l-deprenyl for amphetamine-like discriminative stimulus effects over a range of experimental conditions. male fisher rats were trained under a 5-response, fixed-ratio schedule of stimulus-shock termi ...	1993	8473997
vesicular fast axonal transport rates in young and old rat axons.	an isolated sciatic nerve preparation was used to measure the transport rates of more than 18,000 vesicles in 72 axons from young (3-4 months of age) and old (24-26 months of age) rats from two strains (harlan sprague-dawley and fisher-344). average anterograde and retrograde vesicle transport rates were significantly slower in the older animals. the amount of slowing of anterograde vesicles was twice as great as the slowing of retrograde vesicles. age-related slowing of vesicle transport was in ...	1993	8313149
inhibition of the catechol-o-methyltransferase-catalyzed o-methylation of 2- and 4-hydroxyestradiol by catecholamine: implications for the mechanism of estrogen-induced carcinogenesis.	catechol estrogens have been postulated to mediate estrogen-induced carcinogenesis. as part of our examination of this hypothesis, we studied the catechol-o-methyltransferase-catalyzed o-methylation of 2- and 4-hydroxyestradiol and the inhibition of this reaction by catecholamines. epinephrine, norepinephrine, or dopamine (2 microm) inhibited the methylation of 2- and 4-hydroxyestradiol (20 mm) catalyzed by porcine liver catechol-o-methyltransferase by approximately 28-46% and 37-57%, respective ...	1993	8323288
energy transduction by nitrogenase: binding of mgadp to the mofe protein is dependent on the oxidation state of the iron-sulphur 'p' clusters.	hydrolysis of mgatp to mgadp is essential for nitrogenase action. there is good evidence for binding of both nucleotides to the fe protein of nitrogenase, but data indicating their binding to the mofe protein have been controversial [see miller and eady (1989) biochem. j. 263, 725-729]. the binding of mgadp to the mofe protein of nitrogenase of klebsiella pneumoniae was investigated by non-equilibrium gel-filtration column methods. no binding of mgadp to the dithionite-reduced protein could be d ...	1993	8489498
serum anti-gq1b igg antibody is associated with ophthalmoplegia in miller fisher syndrome and guillain-barré syndrome: clinical and immunohistochemical studies.	to determine the significance of serum anti-gq1b igg antibody, we studied the disease spectrum associated with this antibody and gq1b epitope in the human nervous system. we examined sera from 19 patients with typical miller fisher syndrome (mfs), five patients with acute postinfectious ophthalmoplegia without ataxia (atypical mfs), six patients with guillain-barré syndrome (gbs) with ophthalmoplegia (gbs-op[+]), and 23 patients with gbs without ophthalmoplegia (gbs-op[-]). we also examined sera ...	1993	8413947
effect of acetyl-l-carnitine treatment on brain adenylate cyclase activity in young and aged rats.	the aim of the present study has been to evaluate the effect of acetyl-l-carnitine (alcar) on brain adenylate cyclase (ac) activity in adult and aged rats. in in vitro studies, alcar (1, 10 and 100 microm) did not exert any effect on frontal cortex basal ac activity. acute and subchronic administrations of alcar were carried out in 4- and 25-month-old male fisher rats and ac activity was determined in rat frontal cortex under both basal and stimulated conditions. the acute treatment of young rat ...	1993	8364354
the effects of varying the expression of a neutral cholesteryl ester hydrolase on the turnover of cholesteryl ester in rat hepatoma cells.	a neutral bile salt-dependent cholesteryl ester hydrolase (ceh) in rat liver has been shown to be indistinguishable from the pancreatic ceh by a number of criteria (harrison, e. h. (1988) biochim. biophys. acta 963, 28-34; zolfaghari, r., harrison, e. h., ross, a. c., and fisher, e. a. (1989) proc. natl. acad. sci. u.s.a. 86, 6913-6919; camulli, e. d., linke, m. j., brockman, h. l., and hui, d. y. (1989) biochim. biophys. acta 1005, 177-182). the rat hepatoma cell line fu5ah, which lacks this pa ...	1993	8514786
oxidation of alpha-tocopherol in subcellular fractions from rat brain and its possible involvement in nerve function.	the turnover rate of vitamin e is slow in nerve tissue. therefore, we have developed in vitro techniques to study the biochemical reactions of this nutrient in brain. subcellular fractions were isolated from the cerebral hemispheres of 4-month-old, male, fisher 344 rats. aliquots of fractions (500 micrograms protein) were suspended in 50 mm phosphate buffer at ph 7.4 and incubated at room temperature (20-22 degrees) or 37 degrees for 2 hr in the presence or absence of the following oxidizing age ...	1993	8517870
inhibition of growth of experimental prostate cancer in rats by lh-rh analogs linked to cytotoxic radicals.	the effects of hybrid cytotoxic lh-rh analogs, produced by linking anthraquinone or methotrexate to carrier lh-rh agonist [d-lys6]lh-rh, were evaluated in copenhagen-fisher f1 rats bearing dunning r-3327h prostate adenocarcinoma. the two cytotoxic lh-rh analogs t-98 [(d-lys6)lh-rh coupled to glutaryl-2-(hydroxymethyl)anthraquinone (g-hmaq)], and aj-04 [(d-lys6)lh-rh linked to methotrexate (mtx)], carrier [d-lys6]lh-rh, or the free cytotoxic compounds mtx and g-hmaq were administered from alzet o ...	1993	8378189
tumor-induced alterations in hepatic malic enzyme and carnitine palmitoyltransferase activity.	to better understand the role of the liver in the hypertriglyceridemia observed in a tumor-bearing state, we have examined tumor-induced alterations in hepatic lipogenesis and fatty acid oxidation. the effects of differing tumor burden as well as tumor excision on the activity and mrna levels of malic enzyme and carnitine palmitoyltransferase were studied in fisher 344 rats bearing a methylcholanthrene-induced sarcoma. serum triacylglycerols and plasma nonesterified fatty acids (nefa) levels wer ...	1993	8412123
the heterogeneous temporal evolution of focal ischemic neuronal damage in the rat.	male fisher rats (n = 61) underwent permanent focal cerebral ischemia induced by left middle cerebral artery (mca) occlusion, in conjunction with ipsilateral common carotid artery ligation. the experiments were terminated at time points ranging from immediately following occlusion to 30 days post mca occlusion. a coronal histological section, in close proximity to the site of the arterial occlusion, was taken from each brain and divided into six areas encompassing the affected cortex and caudate ...	1993	8460534
immunorestorative effect of thymostimulin on surgery immunodepression: experimental model.	the purpose of the present study is to ascertain the immunorestorative effect of two different drugs on immunodepression induced by small bowel surgical resection in an experimental model. the potential immunorestorative effect has been measured by the ability of the drug to avoid the delay of skin allograft rejection induced by surgery and the inhibition of cd4/cd8 index changes induced by surgery in spleen tissue. 120 wistar-furth rats (age 12-16 weeks) anesthetized with a single intramuscular ...	1993	8482312
increased atrial natriuretic factor prohormone peptides with aging in the heart, but not in lung, liver, or intestine.	atrial natriuretic factor (anf) has been found to be increased in the circulation of aged rats. the present investigation was designed to determine if the n-terminal anf prohormone peptides with blood pressure lowering properties are increased in the circulation of "aged" (24-26 months) versus "adult" (4-6 month old) fisher 344 rats. we utilized two sensitive and specific radioimmunoassays that immunologically recognize the 98 amino acid (a.a.) n-terminus (proanf 1-98) and a.a. 31-67 (proanf 31- ...	1993	8495993
a multivariate statistical analysis of the composition of rainwater near cubatão, sp, brazil.	with the aim of estimating the chemical composition of bulk precipitation (wet + dry) in cubatão, rainwater samples were collected at several localities in the cubatão region from may 1984 to october 1985. the levels of some inorganic ions (na+, ca2+, k+, mg2+, cl-, so4(2-), nh4+, po4(3-)) were measured by atomic absorption spectrophotometry, turbidimetry and titration analysis. correlation and fisher discrimination indices, principal component and varimax loading and scores were determined in t ...	1993	15091883
occurrence of vibrio alginolyticus in ligurian coast rock pools (tyrrhenian sea, italy) and its association with the copepod tigriopus fulvus (fisher 1860).	a study of heterotrophic bacteria and vibrios adhering to the copepod tigriopus fulvus, which lives in ligurian coast rock pools (tyrrhenian sea), was carried out from november 1990 to october 1991. heterotrophic bacteria, which were always found both free in the water and bound to the t. fulvus organisms, showed a correlation with water temperature and salinity. vibrio alginolyticus was found free in the water and bound to t. fulvus surfaces during the warmest months. temperature is the main fa ...	1993	16348971
treatment and biomechanical assessment of patients with chronic sacroiliac joint syndrome.	to evaluate diagnostic and biomechanical correlates and treatment outcomes of manipulative/adjustive care in patients highly selected for sacroiliac joint syndrome (sijs).	1993	8445358
miller fisher syndrome is associated with serum antibodies to gq1b ganglioside.	a recent report described serum anti-gq1b ganglioside antibodies in miller fisher syndrome (mfs), a clinical variant of guillain-barré syndrome (gbs). four consecutive cases of mfs all had high titre anti-gq1b antibodies which were absent from all control sera including those of patients with gbs.	1993	8437011
paragangliomas. static cytometric studies of nuclear dna patterns.	the biologic behavior of most paragangliomas cannot be predicted from their histologic appearance. recently, cytometric studies have found an association between an aggressive clinical behavior and the presence of a hyperdiploid or tetraploid range in the dna nuclear content.	1993	8431863
dna ploidy and percent s-phase as prognostic factors in node-positive breast cancer: results from patients enrolled in two prospective randomized trials.	to help clarify the clinical utility of flow-cytometric parameters, we performed flow cytometry on archival paraffin-embedded primary breast cancers from 502 patients treated on two adjuvant chemotherapy protocols performed by the north central cancer treatment group (ncctg) and mayo clinic. dna ploidy and percent s-phase (%s) were examined in univariate and cox model multivariate analyses along with tumor size, menopausal and estrogen receptor status, quetelet's index (qi), number of positive n ...	1993	8426213
[clinical analysis of paralytic shellfish poisoning following ingestion of oysters].	we describe five patients of paralytic shellfish poisoning (psp) following ingestion of oysters in january 1991, in nagato, yamaguchi. the five patients (four men and one woman, age range:37-80 years) developed symptoms three-nine hours after consuming oysters. symptoms included paresthesia of the mouth and tongue (three), paresthesia of the extremities (five), and quadriparesis (five). the median duration of neurological symptoms was 16 hours. all five patients completely recovered. although ps ...	1993	8319395
optimization of demographic models with poissonian response.	"the general solution of related estimation and inference problems we can specify as application of fisher scoring algorithm for maximum likelihood estimators with constraints (in section 2).... application to regional fertility patterns (in section 3) yields the simultaneous solutions of tasks about structural fertility differentiations which have not been presented with correct stochastic evaluation.... the functions used for approximations of age-specific fertility schedules coincide with the ...	1993	12291387
express attentional shifts.	"express" saccades, named for their extremely short latencies, occur more frequently in a paradigm with a "gap" in time between the disappearance of the fixation mark and the appearance of the target to be fixated. to explain this result, it has been hypothesized that movements of the eyes are preceded by movements of attention [posner (1980) quarterly journal of experimental psychology, 32, 3-25], and that removing the fixation mark allows attention to disengage from the fovea and to be deploye ...	1993	8451848
first person account: the onset of paranoia.	the article that follows is part of the schizophrenia bulletin's ongoing first person accounts series. we hope that mental health professionals--the bulletin's primary audience--will take this opportunity to learn about the issues and difficulties confronted by consumers of mental health care. in addition, we hope that these accounts will give patients and families a better sense of not being alone in confronting the problems that can be anticipated by persons with serious emotional difficulties ...	1993	8451610
on the probability of loss of new mutations in the presence of linkage disequilibrium.	a new selectively neutral mutation occurs in a multilocus genetic background that has achieved a stable equilibrium at which there is a linkage disequilibrium. perturbation techniques are applied to an extension of the branching process formulation of fisher in order to address the question of extinction probabilities. we show that under appropriate conditions the probability of extinction of the new mutant is increased by the existence of linkage disequilibrium in the genetic background.	1993	8445349
prediction equation estimates of creatinine clearance in the intensive care unit.	to assess the accuracy of 4 mathematical equations used to estimate creatinine clearance versus the 24-h creatinine clearance in icu patients.	1993	8440797
value of having a cytopathologist present during percutaneous fine-needle aspiration biopsy of lung: report of 55 cancer patients and metaanalysis of the literature.	percutaneous fine-needle aspiration biopsy is an accepted procedure for diagnosing intrathoracic malignant disease. the value of having a cytopathologist present during the procedure was studied with respect to the number of needle passes, the accuracy of the procedure, and complications. a metaanalysis was performed on the combined results of the present and previous series.	1993	8416620
[the incidence, localization, sex and mean age in patients with renal carcinoma].	retrospective analysis was made of the clinical case records of 97 nephrectomized patients with renal cancer at the university urologic clinic in rostock, germany. the student-fisher t-criterion was used for statistical processing of the results. the stage of the disease was determined in accordance with the histologic classification of ptnm, suggested in 1988 by the european organization for cancer research and treatment. patients with malignant diseases of the urogenital tract accounted for 6. ...	1993	8411862
impact of prematurity and intrauterine growth retardation on neonatal hemorrhagic and ischemic brain damage.	low birth weight and intrauterine growth retardation are well-recognized risk factors for increased mortality, morbidity and poor neurologic outcome. risk assessment is different considering true preterm (appropriate-for-gestational-age, aga) or growth-retarded (small-for-gestational-age, sga) infants. therefore, we carried out a study on the incidence of hemorrhagic (peri-intraventricular hemorrhage, pivh) and ischemic (periventricular leukomalacia) brain lesions in two groups of aga and sga ve ...	1993	8348917
stereotaxic target calculation. theory and practice.	modern neuro-imaging techniques have significantly increased the accuracy of stereotactic procedures and have thereby generated a renewed interest in guided brain surgery. this paper describes the neuroradiological aspects of stereotaxic target calculation (x-, y-, z- coordinates) using the riechert-mundinger (fisher) frame for computed tomography (ct). selected cases are shown, illustrating patient positioning, ct technique, target identification and calculation. the importance of obtaining pre ...	1993	8279290
the assessment of iadl motor skills: an application of many-faceted rasch analysis.	traditional methods of developing tests have been driven by item content specification and have relied on the use of summed ordinal scores in an attempt to create a quantitative index of ability. there are fundamental problems with this approach to test development. the first problem is that the summing of qualitative ordinal counts to create a total score does not result in a number that is a valid means of making quantitative comparisons of performances. the second problem is that reliance on ...	1993	8322873
[atypical form of miller fisher syndrome].		1993	8511086
estimating selective advantage of two alleles in discrete time.	a class of estimators for the selective advantage, s, in a wright-fisher model with two alleles, variable population size, and genic selection is derived via martingale theory. explicit expressions are given for these estimators which only involve simple computation. the optimal estimate among this class of estimators is obtained. asymptotic results are readily established by an application of a martingale central limit theorem. the performance of this optimal estimator is compared to known esti ...	1993	8263425
[1992 nobel prize of medicine and physiology: edwin krebs and edmond fisher. protein phosphorylation and a hot summer].		1993	8246736
pediatric miller fisher syndrome requiring intubation: a case report.	in 1956, c. miller fisher described a clinical syndrome of ophthalmoplegia, ataxia, and areflexia. this syndrome, which now bears his name, shares certain features with the guillain-barré syndrome (gbs) and generally follows a benign, restricted clinical course, especially in the pediatric population. the authors report a pediatric case of miller fisher syndrome (mfs) who subsequently required intubation and mechanical ventilation.	1993	8344052
miller fisher syndrome mimicking stroke in immunosuppressed patient with rheumatoid arthritis responding to plasma exchange.	a patient with rheumatoid arthritis on immunosuppressive therapy was admitted to hospital with the sudden onset of diplopia and ataxia. because of the history, a stroke was thought most likely. however, as he progressed a diagnosis of the miller fisher syndrome was established. he responded to plasma exchange. this presentation is highly unusual and has not previously been described. in addition, the possibility of immune dysregulation setting the stage for the development of this syndrome is di ...	1993	8340481
an in vitro study of two adhesive systems: third and fourth generations.	the aim of this in vitro study was to compare the adhesive properties of a manufacturer's third and fourth generation dentin adhesive. vestibular sections of recently extracted third molars were embedded in chemical-cured acrylic resin and ground with 600-grit silicon carbide sandpaper. fifteen samples were prepared with the adhesive products and the dentin surfaces were analysed by sem. twenty-four samples were divided into two groups and prepared with third and fourth generation systems, respe ...	1993	7988769
population relationships of lapps as reflected by quantitative dermatoglyphics.	relationships and divergence among five lapp samples were assessed using finger and palm interdigital ridge counts. lapp relationships to other uralic speakers were also assessed. multivariate minimum fst values expressing differentiation among lapps are 0.012. these values are higher than those for most european populations and show the importance of isolation and genetic drift in lapp populations. skolt lapps and lapps of the kola peninsula are generally more similar to each other and are diff ...	1993	8262502
evaluation of mechanically improved conibear 220 traps to quickly kill fisher (martes pennanti) in simulated natural environments.	mechanically improved conibear 220 traps failed to render irreversibly unconscious in < or = 3 min fishers single-struck in the head-neck region, or double-struck in the neck and thorax regions. although the conibear 220 trap is often recommended as an alternative to the steel leghold trap, it is unlikely that it has the potential to humanely kill fisher.	1993	8487383
speech and swallow function after tonsil/base of tongue resection with primary closure.	speech and swallowing function was examined in 11 patients who underwent surgical resection of greater than 1 cm of tongue base, tonsil, and faucial arch with mandible resected on the side of the tumor and reconstruction by primary closure. preoperatively and 1 and 3 months post-healing, high fidelity audio recordings were made of a 6- to 7-minute conversational speech sample, the sentence version of the fisher logemann test of articulation competence was administered, and videofluoroscopic asse ...	1993	8246480
evaluation of the bionic trap to quickly kill fisher (martes pennanti) in simulated natural environments.	the bionic trap equipped with a 10 cm aperture bait cone and cocked to eight notches quickly killed nine of nine fishers (martes pennanti) in simulated natural conditions. mean (+/- se) estimated times to loss of consciousness and heartbeat were < or = 55 sec and 305 (+/- 8) sec, respectively after firing the trap. this study confirmed that the bionic trap can be expected to render > or = 70% of captured fishers irreversibly unconscious in < or = 3 min (p < 0.05).	1993	8487382
characterization of three alleles causing aspartylglycosaminuria: two from a british family and one from an american patient.	aspartylglycosaminuria (agu) is a lysosomal storage disease principally occurring in finland that results from mutations in the structural gene for glycosylasparaginase (agu). this work characterizes the inheritance of two previously reported agu mutations in a british patient [ikonen, aula, grön, tollersrud, halila, manninen, syvänen and peltonen (1991) proc. natl. acad. sci. u.s.a. 88, 11222-11226]. use of the pcr determined the glycosylasparaginase cdna sequence from both parents of the briti ...	1993	8457202
abnormal thyroid function test results in patients with fisher-evans syndrome.	thyroid function was evaluated in patients affected by fisher-evans syndrome (fes) and compared to that of patients affected only by autoimmune hemolytic anemia (aiha) and to that of patients affected only by idiopathic thrombocytopenic purpura (itp). the study population consisted of 20 patients with fes, 44 with aiha and 20 with itp. all patients were examined for thyroid function abnormalities and thyroid autoantibodies. abnormal thyroid function test results were observed in 40, 25 and 10% o ...	1993	8514971
prospective study on the prevention of cerebral vasospasm by intrathecal fibrinolytic therapy with tissue-type plasminogen activator.	the authors have evaluated the efficacy of postoperative intrathecal injections of tissue-type plasminogen activator (tpa) in preventing cerebral vasospasm in patients with a diffuse thick subarachnoid hemorrhage (sah). the present study examined 105 patients who underwent direct surgery within 48 hours of sah and whose computerized tomography (ct) findings were classified as fisher ct group 3. patients showing diffuse thick subarachnoid blood clots on ct with greater than 75 hounsfield units (h ...	1993	8433145
[body image index in the rorschach test in ulcerative proctocolitis].	the use of the rorschach test allows the body image to be examined using the body-image index formulated by fisher-cleveland. this index is obtained by calculating the responses to penetration and barrier. the hypothesis is that the diseases which affect the inside of the body are more greatly correlated to a high p score and a low b score (high p-low b type personality). the paper examines the body-image index in a sample of 41 patients suffering from ulcerous rectocolitis comprising 24 males a ...	1993	8492674
p values, hypothesis tests, and likelihood: implications for epidemiology of a neglected historical debate.	it is not generally appreciated that the p value, as conceived by r. a. fisher, is not compatible with the neyman-pearson hypothesis test in which it has become embedded. the p value was meant to be a flexible inferential measure, whereas the hypothesis test was a rule for behavior, not inference. the combination of the two methods has led to a reinterpretation of the p value simultaneously as an "observed error rate" and as a measure of evidence. both of these interpretations are problematic, a ...	1993	8465801
fetal growth in patients with elevated maternal serum hcg levels.	to determine the relationship between maternal serum hcg levels and small for gestational age (sga) infants.	1993	8437782
early increase precedes a depletion of vip and pgp-9.5 in the skin of insulin-dependent diabetics--correlation between quantitative immunohistochemistry and clinical assessment of peripheral neuropathy.	diabetic neuropathy affects both sensory and autonomic peripheral nerve fibres. vasoactive intestinal polypeptide (vip) is present in autonomic fibres which modulate sweat secretion, while calcitonin gene-related peptide (cgrp) is localized to cutaneous sensory fibres. in this study, immunohistochemistry and image analysis were used to assess changes of vip and cgrp, and of the pan-neuronal marker protein gene-product (pgp)-9.5, in skin biopsies of 18 patients affected by type 1 diabetes (age ra ...	1993	8445492
the value of ploidy in the prognosis of the colorectal cancer.	between the prognostic indices in the colorectal cancer the ploidy has determined a great interest. to study the value of ploidy in the prognosis of the colorectal cancer, as a sign of the aggressiveness of the tumor for a therapeutic help, we have examined, in a retrospective study, 150 patients who had a colorectal cancer resected from 1980 to 1986. we have compared ploidy of specimens of paraffin-embedded tumors and dukes' stage, grading, the over-all, distal and local recurrence and the surv ...	1993	7992556
[systemic lupus erythematosus: a clinical and immunological study of 300 patients].	the aims of the present study were to analyze the clinical and immunologic characteristics of a wide group of patients with systemic lupus erythematosus (sle) and define homogeneous subgroups with their own characteristics.	1993	8497156
a placebo-controlled trial of intravenous and oral disopyramide for prevention of neurally mediated syncope induced by head-up tilt.	a double-blind randomized trial was designed to determine the efficacy of intravenous and oral disopyramide phosphate in preventing neurally mediated syncope induced by a head-up tilt test.	1993	8245337
[motor impersistence].	motor impersistence is the term introduced by fisher to describe the inability to sustain certain simple voluntary acts such as keeping eyes closed, protruding the tongue etc. he considered it a specific, nondominant hemisphere symptom, but some investigators denied its relationship to the right hemisphere damage. we considered that this difference might depend on the following two features of mi; the one is inability to maintain one of these simple acts so long as normal persons do, the other i ...	1993	8174331
placenta accreta is associated with elevated maternal serum alpha-fetoprotein.	to determine whether placenta accreta/percreta/increta is associated with elevation of second-trimester maternal serum alpha-fetoprotein (msafp) levels.	1993	7687756
using computer algebra to determine rate constants in biochemistry.	in earlier work we have described how computer algebra may be used to derive composite rate laws for complete systems of equations, using the mathematical technique of gröbner bases (bennett, davenport and sauro, 1988). such composite rate laws may then be fitted to experimental data to yield estimates of kinetic parameters. recently we have been investigating the practical application of this methodology to the estimation of kinetic parameters for the closed two enzyme system of aspartate amino ...	1993	8266745
[facial angioma and the sturge-weber syndrome: a study of 121 cases].	we show a study in 121 patients with port-wine stain (pws) over the areas of trigeminal nerve sensory innervation, and we analyzed the relations between this distribution, sex and the neuro-ocular disease.	1993	8315969
power studies in the estimation of genetic parameters and the localization of quantitative trait loci for backcross and doubled haploid populations.	a statistical model for doubled haploids and backcrosses based on the interval-mapping methodology has been used to carry out power studies to investigate the effects of different experimental designs, heritabilities of the quantitative trait, and types of gene action, using two test statistics, the f of fisher-snedecor and the lod score. the doubled haploid experimental design is more powerful than backcrosses while keeping actual type i errors similar to nominal ones. for the doubled haploid d ...	1993	24193587
scleral flap sutures and the development of shallow or flat anterior chamber after trabeculectomy.	to determine whether closing the scleral flap with extra sutures can reduce the risk of overfiltration after trabeculectomy, we divided 339 trabeculectomies into three groups based on the number of scleral flap sutures used in the procedure, and studied the postoperative complications and results. the incidence of shallow or flat anterior chamber was significantly less in eyes that had received seven to nine sutures than in those that had received from two to six. also, the incidence of cornea-l ...	1993	8515946
the performance of two intensive care humidifiers at high gas flows.	high continuous flow breathing systems are now available to provide fresh gas flows well in excess of 100 l.min-1 in continuous positive airway pressure systems used for respiratory support. the performance of two commonly used intensive care humidifiers, the kendal conchatherm and the fisher and paykel fp310 have been assessed at flows of 50, 75, 100, 125 and 150 l.min-1. their performance when using two humidifiers connected in parallel and in series was also studied. at a fresh gas flow of 10 ...	1993	8238837
mitral valve carpentier-edwards bioprosthetic replacement, thromboembolism, and anticoagulants.	patients undergoing mitral valve replacement (mvr) using a bioprosthesis are frequently placed on long-term anticoagulant treatment, and thereby lose the main advantage conferred by the bioprosthesis. to assess predictive factors of the need for long-term anticoagulant treatment, 100 consecutive patients surviving bioprosthetic mvr between 1977 and 1987 were followed up. the estimated thromboembolism-free survival was 88.9% +/- 3.6% after 6 years of follow-up. preoperative risk factors for throm ...	1993	8215671
issues of consequence.	rapid advances in scientific knowledge and technology engender ethical and moral concerns. the explosion of new genetic information is bringing about changes that will affect virtually every aspect of our lives. jeffrey fisher, md, author of rx 2000, reports on health care breakthroughs we will see during the next 40 years. this article touches on just a few of the exciting, innovative, and sometimes troubling possibilities.	1993	8106995
20-year experience in childhood craniopharyngioma.	the management of craniopharyngioma is controversial, and surgery alone is frequently advocated. the purpose of this study was to assess the long-term impact of various treatments in childhood craniopharyngioma.	1993	8407391
flow cytometric crossmatch and early pregnancy loss in women with a history of recurrent spontaneous abortions who underwent paternal leukocyte immunotherapy.	the purpose of our study was to evaluate the clinical significance of flow cytometric crossmatch in managing women with unexplained recurrent spontaneous abortions who have been immunized with paternal leukocytes.	1993	8498439
profiles of women age 30-39 and age less than 30 with epithelial ovarian cancer.	to study a group of women diagnosed with epithelial ovarian cancer at a young age (less than 40).	1993	8469449
effect of age on survival in acute leukemia. 1950-1990.	four decades ago, survival of patients with acute leukemia was brief at any age. since 1950, survival of children has increased remarkably but has changed little for the elderly. the nature and magnitude of this age difference in survival are not understood.	1993	8348491
venous thromboembolism and high grade gliomas.	a retrospective study was done to determine the incidence of and the risk factors predisposing to clinical venous thromboembolism (vte) in patients treated for high grade gliomas. medical records of 68 consecutive patients diagnosed and treated at saint francis hospital and medical center from january 1986 to june 1991 were reviewed. the follow up was to time of death or at least 6 months (up to december 1991). all clinically suspected episodes of vte were confirmed by objective tests. sixteen e ...	1993	8259536
performances on the nbme i, ii, and iii by medical students in the problem-based learning and conventional tracks at the university of new mexico.	problem-based learning curricula are growing in popularity, and questions have been raised about the appropriateness of standardized examinations, such as the national board of medical examiners (nbme) parts i, ii, and iii examinations, for assessing students in these new curricula.	1993	8352874
[prospective study of cataract after 5 years intraocular lenses with and without laser ridge].	a prospective randomized study was carried out to investigate whether intraocular lenses with and without laser ridge have different effects on the development of secondary cataract.	1993	8231041
which neuropsychological deficits are hidden behind a good outcome (glasgow = i) after aneurysmal subarachnoid hemorrhage?	a series of 31 patients with good neurological 6-month outcomes (glasgow outcome scale = i) was examined with a battery of cognitive tests 1 to 5 years after aneurysmal subarachnoid hemorrhage (sah) and early operation. the results showed a marked disability in 28 to 62% of these patients in the subtests of a complex choice reaction task. short-term memory was impaired in 53% of the patients neuropsychologically examined, whereas 21% of them had a reduced long-term memory. concentration was impa ...	1993	8134014
[2 solutions for estimating odds ratios with zeros].	two solutions are proposed for the estimation of odds ratios (or) when one or the two elements of the principal (a, d) or secondary (b, c) diagonals of a 2 x 2 matrix (a, b, c, d) are 0. the or estimate is ad/bc. if a or d are 0, or = 0; if b or c are 0, the or is undefined. analytical solution. this solution conserves the marginal totals. if b = 0 and c = 0, the or cannot be less than ad/1 (the minimal acceptable value), then the equation (a-x) (d-x)/x2 = kad/1 searches for that x which subtrac ...	1993	8085071
direct and indirect estimation of the sex ratio of mutation frequencies in hemophilia a.	carrier detection tests were carried out in 119 families with hemophilia a by using the data obtained with current dna techniques (e.g., rflp analysis and direct identification of mutations), conventional carrier detection tests (e.g., factor viii:c and von willebrand factor antigen), and pedigree information. on the basis of this data, we estimated the sex ratio of mutation frequencies with three completely different methods and compared the results. since the classical indirect method derived ...	1993	7902674
miller fisher syndrome, a brainstem encephalitis, mimics brain death.	miller fisher syndrome is a rare focal encephalitis of the brainstem characterized by cranial nerve palsy, ataxia, and areflexia. while this condition usually is mild and self-limiting, as this case documents, findings may fulfill many of the criteria in the clinical examination for brain death. unlike brain death, however, it is not associated with irreparable structural damage of the brain or, as is mandatory, does it fulfill a very important prerequisite of brain death, the exclusion of poten ...	1993	8299301
cerebral hemodynamics in subarachnoid hemorrhage evaluated by transcranial doppler sonography. part 2. pulsatility indices: normal reference values and characteristics in subarachnoid hemorrhage.	in previous publications on the diagnostic value of transcranial doppler sonography (tcd), conflicting results concerning predictive capacities for evaluating vasospasm by measuring flow velocities were reported, and the necessity to examine pulsatility indices (pis) was stressed. pis are known to give useful information on cerebral hemodynamics in cases of stenosis of the extracranial internal carotid artery and cerebral arteriovenous malformations. whether the examination of pis can give addit ...	1993	8355825
visual-acuity development in healthy preterm infants: effect of marine-oil supplementation.	docosahexaenoic acid (dha; 22:6n-3) is important for normal visual development. we hypothesized that preterm infants fed formulas with marine oil as a source of dha would have better visual acuity than infants fed formulas without marine oil, as measured by the teller acuity card procedure. marine oil (p < 0.001) and age (p < 0.0001) influenced visual acuity, by repeated-measures analysis of variance (anova) corrected for the effect of subject. marine-oil-supplemented infants had better visual a ...	1993	8317386
radiosurgery for acoustic neuroma.	radiosurgery has been used for many years with great success for the treatment of acoustic neuroma. we present three cases in louisiana using the e l fisher system, the results of treatment, and a discussion of acoustic neuroma.	1993	8228537
immunoglobulin subclass distribution and binding characteristics of anti-gq1b antibodies in miller fisher syndrome.	circulating igg antibodies to carbohydrate determinants on gq1b ganglioside are found in the acute phase sera of patients with miller fisher syndrome, a variant of guillain-barré syndrome. here we report that the igg subclass distribution of the anti-gq1b antibodies is mainly restricted to igg1 and igg3 antibodies, subclasses typically associated with a t cell-dependent immune response to protein antigens. this is highly unusual in that igg responses to carbohydrate determinants are typically of ...	1994	8120137
neuro-ophthalmic manifestations of the syndrome of ophthalmoplegia, ataxia and areflexia: a review.	controversy regarding the nosological position of the syndrome of ophthalmoplegia, ataxia and areflexia (miller fisher syndrome) exists. the oculomotor dysfunction was presumed to represent an unusually symmetrical peripheral cranial nerve dysfunction. to investigate the neuro-ophthalmic manifestations in this rare syndrome we reviewed 109 reports describing 243 cases. the ophthalmoplegia was remarkable in its constant association with a cerebellar type ataxia. it was described to be remarkably ...	1994	8030396
fisher's game with the devil.	the publication of fisher's correspondence on statistics has shed new light on his views on randomization. quotations from this correspondence and from other works of fisher are used to illustrate the role of randomization in clinical trials. it is concluded that fisher's views not only are coherent but, despite having been developed over 60 years ago and with particular reference to agricultural experiments, are still relevant to the planning and analysis of clinical trials today.	1994	8202650
high-dose oxytocin: 20- versus 40-minute dosage interval.	to determine whether an increase in the oxytocin dosing interval would decrease the incidence of uterine hyperstimulation.	1994	8290186
[initial prognostic factors of aneurysmal subarachnoid hemorrhage].	the purpose of this retrospective study is to explain, using a total of 210 consecutive patients with aneurysmal subarachnoid hemorrhage, the survival by several prognostic factors measured at the admission time. a multivariate analysis using the cox proportional hazards model allowed one to recognize five prognostic factors: secondary arterial hypertension (risk ratio (rr) = 1.8; p = 0.03), the hunt and hess grade-3 (rr = 3.3; p = 0.002), the hunt and hess grade-4 (rr = 7.3; p = 0.007), and the ...	1994	7997314
the exact analysis of contingency tables in medical research.	a unified view of exact nonparametric inference, with special emphasis on data in the form of contingency tables, is presented. while the concept of exact tests has been in existence since the early work of ra fisher, the computational complexity involved in actually executing such tests precluded their use until fairly recently. modern algorithmic advances, combined with the easy availability of inexpensive computing power, has renewed interest in exact methods of inference, especially because ...	1994	7952429
[a statistical mean dyad test (tt-criteria for comparison of mean trends of two samples)].	the authors claim that widely used statistic tests (student, berence-fisher, wilcoxon-mann-whitney, etc.) may fail to detect differences in average trends. a new statistical tt-test is suggested for such situations when samples are compared belonging to essentially different distributions and one of these distributions is bimodal or u-shaped. this test consists in comparison of the arithmetic means calculated not for the whole sample but separately for values higher and lower than the respective ...	1994	7921822
presence of non-fibrillar amyloid beta protein in skin biopsies of alzheimer's disease (ad), down's syndrome and non-ad normal persons.	a total of 66 skin biopsies from persons with alzheimer's disease (ad) or down's syndrome (ds) and from persons without ad were used in this study. the age range was from 7 to 89 years. positive immunoreactivity of skin biopsies to monoclonal antibody 4g8, which is reactive to amino acid residue 17-24 of synthetic amyloid beta protein (a beta), and 4g8-fab (the antigen-binding fragment of 4g8 igg, reactive only to amyloid plaque) was observed in the epidermis-dermis junction or the basement memb ...	1994	7810290
effects of prophylactic intrathecal administrations of nicardipine on vasospasm in patients with severe aneurysmal subarachnoid haemorrhage.	calcium antagonists are currently most widely used for chronic cerebral vasospasm after aneurysmal subarachnoid haemorrhage (sah). however, the vasodilatory effects of systemically administered calcium antagonists can be limited secondary to hypotension. we previously compared intrathecal and intravenous routes of administration of nicardipine. intrathecal administration of nicardipine significantly dilated spastic basilar arteries on day 7 in a two-haemorrhage canine model of vasospasm. in the ...	1994	7709781
association of the ss genotype of the l-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers.	l-myc is a nuclear oncogene which is sometimes activated late in tumourigenesis. digestion of dna with ecori reveals a simple restriction fragment length polymorphism (rflp) located in the second intron of l-myc, with allele sizes 10 kb (l-allele) and 6.6 kb (s-allele). some studies have suggested that the presence of the s-allele in the constitutional dna of a patient with cancer is associated with a higher risk of metastasis in lung, breast and renal cell carcinomas. the aims of this study wer ...	1994	7907781
[an opinion/satisfaction survey on 2 models of clinical histories used in primary care].	we aimed to discover the opinion of primary care doctors regarding the structure, usefulness and problems when using two models of clinical records employed consecutively in the same health centres.	1994	8180304
pregnancy following cardiac prosthetic valve replacement.	to determine the effect of cardiac valve replacement on pregnancy outcome.	1994	8127524
brinley plots, explained variance, and the analysis of age differences in response latencies.	critics of brinley plot analyses (e.g., fisk, fisher, & rogers, 1992; perfect, 1994) claim: (a) that lack of overlap between latencies on different tasks inflates r2 values; (b) that brinley plots mask task-specific age differences; and (c) that measurement error in young adults' latencies precludes the use of regression techniques with brinley plot data. we dispute these claims. we show that lack of overlap does not inflate r2 and that the possible presence of task-specific effects in brinley p ...	1994	8126362
a phylogenetic estimator of effective population size or mutation rate.	a new estimator of the essential parameter theta = 4ne mu from dna polymorphism data is developed under the neutral wright-fisher model without recombination and population subdivision, where ne is the effective population size and mu is the mutation rate per locus per generation. the new estimator has a variance only slightly larger than the minimum variance of all possible unbiased estimators of the parameter and is substantially smaller than that of any existing estimator. the high efficiency ...	1994	8150291
patterns of failure following loco-regional radiotherapy in the treatment of limited stage small cell lung cancer.	the probability of treatment resistant cells developing in a tumor, such as small cell lung cancer (sclc) which has a rapid cell cycle time, is a function of the number of tumor cells present and of time. theoretically, the development of resistance to chemotherapy and radiotherapy should be minimized by using all treatment modalities early in the treatment program.	1994	8276650
r. a. fisher on karl pearson.		1994	11615277
stability of metacarpal ii dimensions in boys during adolescence.	the stability of radiogrammetrically determined metacarpal ii (m ii) bone dimensions was determined in 184 belgian boys between 13 and 18 years of age. stability was assessed by fisher z transformations of pearson correlations between discrete measurement intervals and by structured covariance analysis incorporating compound, banded, and autoregressive models. adjacent-age stability (1-year measurement interval) was high (0.82 ⩽ r ⩽ 0.97) for all metacarpal dimensions for all approaches, but sta ...	1994	28548261
chorioamnionitis: association of nonreassuring fetal heart-rate patterns and interval from diagnosis to delivery on neonatal outcome.	the purpose of this study was to determine whether selected fetal heart-rate (fhr) patterns and the interval from diagnosis to delivery in pregnancies complicated by chorioamnionitis could predict neonatal outcome.	1994	18475385
high dose immunoglobulin therapy is effective in the miller fisher syndrome.		1994	8164023