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the crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium bartonella henselae strain houston-1 at 2.3 å resolution.in bacteria, the second committed step in the diaminopimelate/lysine anabolic pathways is catalyzed by the enzyme dihydrodipicolinate reductase (dapb). dapb catalyzes the reduction of dihydrodipicolinate to yield tetrahydrodipicolinate. here, the cloning, expression, purification, crystallization and x-ray diffraction analysis of dapb from the human-pathogenic bacterium bartonella henselae, the causative bacterium of cat-scratch disease, are reported. protein crystals were grown in conditions co ...201627917836
bartonella endocarditis and pauci-immune glomerulonephritis: a case report and review of the literature.among culture-negative endocarditis in the united states, bartonella species are the most common cause, with bartonella henselae and bartonella quintana comprising the majority of cases. kidney manifestations, particularly glomerulonephritis, are common sequelae of infectious endocarditis, with nearly half of all bartonella patients demonstrating renal involvement. although a pauci-immune pattern is a frequent finding in infectious endocarditis-associated glomerulonephritis, it is rarely reporte ...201627885316
prosthetic valve endocarditis caused by bartonella henselae: a case report of molecular diagnostics informing nonsurgical management.identifying the pathogen responsible for culture-negative valve endocarditis often depends on molecular studies performed on surgical specimens. a patient with ehlers-danlos syndrome who had an aortic graft, a mechanical aortic valve, and a mitral anulloplasty ring presented with culture-negative prosthetic valve endocarditis and aortic graft infection. research-based polymerase chain reaction (pcr)/electrospray ionization mass spectrometry on peripheral blood samples identified bartonella hense ...201627844027
status epilepticus due to cat scratch disease: recognition, diagnosis, and thoughts on pathogenesis.despite the publication of a number of case reports since the 1950s, physician awareness of the unique relationship between cat scratch disease (csd) and acute encephalopathy remains limited. this report alerts emergency medicine physicians to include csd encephalopathy (csde) in the differential diagnosis when a previously healthy child presents with status epilepticus. prompt recognition of this relationship impacts the selection of initial diagnostic studies and antibiotic choices and permits ...201625853722
a family of genus-specific rnas in tandem with dna-binding proteins control expression of the bada major virulence factor gene in bartonella henselae.bartonella henselae is a gram-negative zoonotic bacterium that causes infections in humans including endocarditis and bacillary angiomatosis. b. henselae has been shown to grow as large aggregates and form biofilms in vitro. the aggregative growth and the angiogenic host response requires the trimeric autotransporter adhesin bada. we examined the transcriptome of the houston-1 strain of b. henselae using rna-seq revealing nine novel, highly-expressed intergenic transcripts (bartonella regulatory ...201627790856
management of a 16-year-old with axillary lymphadenopathy: the cat's in the bag. 201627742481
thoracic osteomyelitis and epidural abscess formation due to cat scratch disease: case report.osteomyelitis of the spine with associated spinal epidural abscess represents an uncommon entity in the pediatric population, requiring prompt evaluation and diagnosis to prevent neurological compromise. cat scratch disease, caused by the pathogen bartonella henselae, encompasses a wide spectrum of clinical presentations; however, an association with osteomyelitis and epidural abscess has been reported in only 4 other instances in the literature. the authors report a rare case of multifocal thor ...201627662446
cat-scratch disease in the united states, 2005-2013.cat-scratch disease (csd) is mostly preventable. more information about the epidemiology and extent of csd would help direct prevention efforts to those at highest risk. to gain such information, we reviewed the 2005-2013 marketscan national health insurance claims databases and identified patients <65 years of age with an inpatient admission or outpatient visit that included a csd code from the international classification of diseases, ninth revision, clinical modification. incidence of csd was ...201627648778
[seroprevalence of bartonella henselae in occupational risk persons].bartonella henselae infection is a worldwide zoonosis with the domestic cat as reservoir. although people with occupational contact with these pets are risk population only few studies of prevalence in them have been reported.201627598290
zoonotic and vector-borne infections among urban homeless and marginalized people in the united states and europe, 1990-2014.in high-income countries, homeless individuals in urban areas often live in crowded conditions with limited sanitation and personal hygiene. the environment of homelessness in high-income countries may result in intensified exposure to ectoparasites and urban wildlife, which can transmit infections. to date, there have been no systematic evaluations of the published literature to assess vector-borne and zoonotic disease risk to these populations.201627159039
bartonella henselae transmission by blood transfusion in mice.bartonella spp. are neglected fastidious gram-negative bacilli. we isolated bartonella henselae from 1.2% of 500 studied blood donors and demonstrated that the bacteria remain viable in red blood cell units after 35 days of experimental infection. now, we aim to evaluate the possibility of b. henselae transmission by blood transfusion in a mouse model.201626968530
analysis of endothelial adherence of bartonella henselae and acinetobacter baumannii using a dynamic human ex vivo infection model.bacterial adherence determines the virulence of many human-pathogenic bacteria. experimental approaches elucidating this early infection event in greater detail have been performed using mainly methods of cellular microbiology. however, in vitro infections of cell monolayers reflect the in vivo situation only partially, and animal infection models are not available for many human-pathogenic bacteria. therefore, ex vivo infection of human organs might represent an attractive method to overcome th ...201626712205
cloning, expression, purification, crystallization and x-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium bartonella henselae strain houston-1 at 2.1 å resolution.the enzyme dihydrodipicolinate synthase catalyzes the committed step in the synthesis of diaminopimelate and lysine to facilitate peptidoglycan and protein synthesis. dihydrodipicolinate synthase catalyzes the condensation of l-aspartate 4-semialdehyde and pyruvate to synthesize l-2,3-dihydrodipicolinate. here, the cloning, expression, purification, crystallization and x-ray diffraction analysis of dihydrodipicolinate synthase from the pathogenic bacterium bartonella henselae, the causative bact ...201626750477
transfer of dna from bacteria to eukaryotes.historically, the members of the agrobacterium genus have been considered the only bacterial species naturally able to transfer and integrate dna into the genomes of their eukaryotic hosts. yet, increasing evidence suggests that this ability to genetically transform eukaryotic host cells might be more widespread in the bacterial world. indeed, analyses of accumulating genomic data reveal cases of horizontal gene transfer from bacteria to eukaryotes and suggest that it represents a significant fo ...201627406565
bartonella henselae as a putative cause of congenital cholestasis.severe anemia and cholestatic hepatitis are associated with bartonella infections. a putative vertical bartonella henselae infection was defined on the basis of ultrastructural and molecular analyses in a three-year-old child with anemia, jaundice and hepatosplenomegaly since birth. physicians should consider bartonellosis in patients with anemia and hepatitis of unknown origin.201627410916
detection of vector-borne pathogens in cats and their ectoparasites in southern italy.vector-borne pathogens are the subject of several investigations due to the zoonotic concern of some of them. however, limited data are available about the simultaneous presence of these pathogens in cats and their ectoparasites. the aim of the present study was to define the species of ectoparasites found on cats as well as to investigate vector-borne pathogens in cats and their ectoparasites in southern italy.201627160725
molecular identification and phylogenic analysis of bartonella henselae isolated from iranian cats based on glta gene.one of the most important species of the bartonella genus is b. henselae that causes a zoonotic infection, cat scratch disease (csd). the main source of the bacteria is cat and the carrier is ctenocephalides felis flea. one hundred and forty nail and saliva samples were collected from 70 domestic cats. positive samples for b. henselae were characterized by polymerase chain reaction (pcr) and sequencing. sequences of glta gene were trimmed using bioedit software and then compared with the sequenc ...201627226890
synthesis of 5-o-oligoglucosyl extended α-(2→4)-kdo disaccharides corresponding to inner core fragments of moraxellaceae lipopolysaccharides.the heptose-deficient inner core of the lipopolysaccharide of several pathogenic strains of the moraxellaceae family (moraxella, acinetobacter) and of bartonella henselae, respectively, comprises an α-d-glucopyranose attached to position 5 of kdo. in continuation of the synthesis of fragments of acinetobacter haemolyticus lps, the branched α-glcp-(1 → 5)[α-kdo-(2 → 4)]-α-kdo trisaccharide motif was elaborated. the glycosylation of a suitably protected, α-(2 → 4)-interlinked kdo-disaccharide was ...201626795079
[lyme borreliosis and co-infections. place of anaplasma phagocytophilum and bartonella henselae].lyme borreliosis (lb) is certainly the most common infection transmitted through the bite of ixodes in northern hemisphere. these ticks are also able to transmit other microorganisms such as the bacteria anaplasma phagocytophilum (ap) and bartonella henselae (bh), with the latter discovered fairly recently, leading to diferent clinical presentations often close to those of lb. the aim of this study was to evaluate the frequency of co-infection by either of these bacteria in patients with lb, par ...201627509682
seroprevalence of seven pathogens transmitted by the ixodes ricinus tick in forestry workers in france.in order to assess the level of occupational exposure to the main pathogens transmitted by the ixodes ricinus tick, a seroprevalence study was performed on serum samples collected in 2003 from 2975 forestry workers of northeastern france. the global seroprevalence estimated for the seven pathogens studied was 14.1% (419/2975) for borrelia burgdorferi sl, 5.7% (164/2908) for francisella tularensis, 2.3% (68/2941) for tick-borne encephalitis virus, 1.7% (50/2908) for anaplasma phagocytophilum and ...201627237545
novel approach for evaluation of bacteroides fragilis protective role against bartonella henselae liver damage in immunocompromised murine model.bartonella henselae is a gram-negative facultative intracellular bacterium and is the causative agent of cat-scratch disease. our previous data have established that bacteroides fragilis colonization is able to prevent b. henselae damages through the polysaccharide a (psa) in an experimental murine model. in order to determine whether the psa is essential for the protection against pathogenic effects of b. henselae in immunocompromised hosts, scid mice were co-infected with b. fragilis wild type ...201627872616
paleomicrobiology of bartonella infections.studying ancient infectious diseases is a challenge, as written contemporary descriptions, when available, are often imprecise and do not allow for accurate discrimination among the pathogens endemic at that time. paleomicrobiology offers a unique access to the history of these infections by identifying precisely the causative agents. body louse-transmitted infections are amongst the most epidemic diseases in history, especially in war and famine periods. of these, bartonella quintana was detect ...201626369716
assessment of a quantitative 5' nuclease real-time polymerase chain reaction using the nicotinamide adenine dinucleotide dehydrogenase gamma subunit (nuog) for bartonella species in domiciled and stray cats in brazil.the objective of this study was to develop a quantitative 5' nuclease real-time polymerase chain reaction (pcr) assay to diagnose infections caused by bartonella species.201626138812
prevalence, hematological findings and genetic diversity of bartonella spp. in domestic cats from valdivia, southern chile.the present study determined the prevalence, hematological findings and genetic diversity of bartonella spp. in domestic cats from valdivia, southern chile. a complete blood count and nuog gene real-time quantitative pcr (qpcr) for bartonella spp. were performed in 370 blood samples from cats in valdivia, southern chile. nuog qpcr-positive samples were submitted to conventional pcr for the glta gene and sequencing for species differentiation and phylogenetic analysis. alignment of glta gene was ...201627938417
molecular evidence of vector-borne pathogens in dogs and cats and their ectoparasites in algiers, algeria.in algeria, only limited information is currently available on the prevalence of emergent canine and feline vector-borne diseases. the aim of the present work was to detect by qpcr vector-associated bacteria in stray dogs and cats and their ectoparasites from algiers. 18/117 (15.38%) dogs and 2/107 (1.87%) cats were positive for at least one vector-borne agent. coxiella burnetii and bartonella henselae were identified in 1/117 (0.85%) dog individually. ehrlichia canis dna was detected in 17/117 ...201627012917
experimental infection of horses with bartonella henselae and bartonella bovis.experimental infection of horses with bartonella species is not documented.201622356473
bartonella species pathogenic for humans infect pets, free-ranging wild mammals and their ectoparasites in the caatinga biome, northeastern brazil: a serological and molecular study.this study verified the occurrence of bartonella spp. in dogs, cats, wild mammals and their ectoparasites in petrolina and lagoa grande counties, pernambuco, located in a semi-arid region in northeastern brazil. anti-bartonella spp. antibodies were detected by indirect immunofluorescence assay (ifa) in 24.8% of dogs (27/109) and in 15% of cats (6/40). bartonella sp. dna was identified by pcr performed on dna extracted from blood and ectoparasites using primers targeting bartonella sp. glta and r ...201728249707
intestinal parasites and vector-borne pathogens in stray and free-roaming cats living in continental and insular greece.this survey investigated the distribution of various intestinal parasites and vector-borne pathogens in stray and free-roaming cats living in four regions of greece. a total number of one hundred and fifty cats living in three islands (crete, mykonos and skopelos) and in athens municipality was established as a realistic aim to be accomplished in the study areas. all cats were examined with different microscopic, serological and molecular assays aiming at evaluating the occurrence of intestinal ...201728141857
prevalence of bartonella species infections in cats in southern germany.bartonella species are zoonotic pathogens, and infections in cats are common. however, prevalence in cats in southern germany is still unknown. therefore, prevalence of bartonella species dna in blood of 479 southern german cats was determined using a previously published conventional pcr targeting a fragment of the 16s-23s rrna intergenic spacer region. associations between bartonella bacteraemia, housing conditions, feline immunodeficiency virus (fiv) and feline leukaemia virus (felv) status, ...201728130406
prevalence and potential risk factors for bartonella infection in tunisian stray dogs.bartonellae are blood-borne and vector-transmitted pathogens, some are zoonotic, which have been reported in several mediterranean countries. transmission from dogs to humans is suspected, but has not been clearly demonstrated. our objectives were to determine the seroprevalence of bartonella henselae, bartonella vinsonii subsp. berkhoffii, bartonella clarridgeiae, and bartonella bovis (as a proxy for candidatus bartonella merieuxii) in stray dogs from tunisia, identify the bartonella species in ...201728346866
prevalence study and risk factor analysis of selected bacterial, protozoal and viral, including vector-borne, pathogens in cats from cyprus.feline infectious agent studies are lacking in cyprus. the aims of this study were to determine the prevalence and risk factors for various feline infectious agents, including feline vector-borne pathogens (fvbp), in cats from cyprus.201728285597
draft genome sequences of 12 feline bartonella henselae isolates.bartonella henselae is the main causative agent of cat scratch disease. in this report, we present the draft genome sequences of 12 strains of bartonella henselae originating from the united states, denmark, and france. these strains were isolated from cats and belonged to either 16s rrna genotype i or 16s rrna genotype ii.201728360154
bartonella-associated transverse myelitis.each year in the united states, 500 patients are hospitalized for cat-scratch disease, caused by bartonella henselae infection. we report a case of rare but serious neurologic b. henselae infection. when typical features of cat-scratch disease occur with neurologic findings, bartonella infection should be suspected and diagnostic testing should be performed.201728322716
molecular detection of hepatozoon spp. and cytauxzoon sp. in domestic and stray cats from madrid, spain.different species of apicomplexan protozoans of the genera hepatozoon and cytauxzoon can infect domestic cats, but their epidemiology and clinical relevance are not fully understood. the aim of this study was to assess the molecular prevalence of hepatozoon spp. and cytauxzoon spp. and to identify associated risk factors and clinical and laboratory abnormalities in a population of cats from madrid, spain.201728285590
molecular detection of bartonella henselae in 11 ixodes ricinus ticks extracted from a single cat.bartonella henselae is a highly prevalent, vector-borne pathogen. transmission to humans and animals by ticks is discussed controversially. here, we present a case report, where eleven ixodes ricinus ticks all harbouring b. henselae dna were removed from one single cat.201728285589
bartonella henselae in canine cavitary effusions: prevalence, identification, and clinical associations.previous reports suggest an association between bartonella infection and effusions in dogs and human beings.201728263407
cat scratch disease during etanercept therapy in a rheumatoid arthritis patient.cat scratch disease (csd) is an infectious disorder caused by bartonella henselae and characterized by fever and granulomatous lymphadenopathy. immunosuppression is a risk factor for the development of atypical forms of the disease. we report the case of a 52-year-old woman who presented with fever and bilateral inguinal lymph node enlargement. she did not have apparent contact with animals. the patient was receiving etanercept therapy for rheumatoid arthritis. lymph node biopsy demonstrated gra ...201728256443
prolonged course of hepatic granulomatous disease due to bartonella henselae infection.cat-scratch disease (csd) is an emerging zoonosis caused by bartonella henselae. the disease is usually self-limiting and typically presents in about 90% of all cases as a subacute regional lymphadenopathy. we present a case report of an unusual csd presentation, persistent hepatic granulomatous disease due to bartonella henselae infection despite combination therapy with doxycycline and rifampicin. furthermore, a review of literature was conducted. (acta gastroenterol. belg., 2016, 79, 497-499) ...201728209111
disseminated cat-scratch disease presenting as nausea, diarrhea, and weight loss without fever in a heart transplant recipient.we report the case of an afebrile 59-year-old heart transplant recipient presenting with nausea, vomiting, diarrhea, weight loss, and diffuse lymphadenopathy. lymph node biopsies revealed non-caseating granulomatous inflammation. cat-scratch disease was confirmed by serologic studies, warthin-starry staining, and polymerase chain reaction testing of lymph node tissue. the patient's symptoms resolved with 3 months of doxycycline. we review clinical presentations of bartonella henselae infection i ...201728199763
diverse clinical signs of ocular involvement in cat scratch disease.to describe ocular manifestations, diagnosis, and treatment of cat scratch disease.201728182175
acute and late bartonella henselae murine model infection.bartonella spp. are fastidious gram-negative neglected bacilli with worldwide distribution. they are able to cause intraerythrocytic and potentially fatal infection. cats and dogs are reservoirs of some species of these agents. blood-sucking arthropods are potential vectors. our aim was to evaluate the blood, skin, liver, and spleen in balb/c mice by using molecular tests and confocal microscopy to demonstrate bartonella henselae infection in the bloodstream and organs after 4 and 21 days of int ...201728165916
dynamics of co-infection with bartonella henselae genotypes i and ii in naturally infected cats: implications for feline vaccine development.bartonella henselae is an emerging bacterial pathogen causing cat-scratch disease and potentially fatal bacillary angiomatosis in humans. bacteremic cats constitute a large reservoir for human infection. although feline vaccination is a potential strategy to prevent human infection, selection of appropriate b. henselae strains is critical for successful vaccine development. two distinct genotypes of b. henselae (type i, type ii) have been identified and are known to co-infect the feline host, bu ...201728150014
bacillary angiomatosis with bone invasion.bacillary angiomatosis is an infection determined by bartonella henselae and b. quintana, rare and prevalent in patients with acquired immunodeficiency syndrome. we describe a case of a patient with aids and tcd4+ cells equal to 9/mm3, showing reddish-violet papular and nodular lesions, disseminated over the skin, most on the back of the right hand and third finger, with osteolysis of the distal phalanx observed by radiography. the findings of vascular proliferation with presence of bacilli, on ...201728099606
the utility of a country-specific bartonella henselae antigen in an igm-indirect fluorescent antibody assay for the improved diagnosis of cat scratch disease.bartonella henselae strains genetically differ among nations. the utility of japanese-specific yh-01 strain was investigated in developing indirect fluorescence antibody assay (ifa) for igm in comparison with conventional ifa employing houston-1 strain by testing 100 japanese patients suspected of cat scratch disease. the country-specific ifa greatly improved the accuracy of diagnosis.201728029424
role of whole-body mr with dwibs in child's bartonellosis.cat-scratch disease (csd) is a zoonosis in children, result of infection by bartonella henselae, a gram-negative bacillus. infection is generally characterized by regional and self-limited lymphadenopathy after exposure to a scratch or bite from a cat. rarely, b. henselae is cause of fever of unknown origin (fuo), with dissemination to various organs, most often involving the reticuloendothelial system (liver, spleen, bone marrow), mimicking an inflammatory rather than a lymphoproliferative dise ...201727598022
bartonella henselae infective endocarditis detected by a prolonged blood culture.a 65-year-old japanese man was admitted with a 4-month history of fatigue and exertional dyspnea. transthoracic echocardiography revealed a vegetation on the aortic valve and severe aortic regurgitation. accordingly, infective endocarditis and heart failure were diagnosed. although a blood culture was negative on day 7 after admission, a prolonged blood culture with subculture was performed according to the patient's history of contact with cats. consequently, bartonella henselae was isolated. b ...201727746451
pyogranulomatous pancarditis with intramyocardial bartonella henselae san antonio 2 (bhsa2) in a dog. 201727883248
parinaud's oculoglandular syndrome: a case report.a 33-year old woman presents with unilateral granulomatous conjunctivitis, ipsilateral regional lymphadenopathy and fever. a bartonella henselae infection is demonstrated by indirect immunofluorescence, and a diagnosis of a parinaud's oculoglandular syndrome is established. outcome after treatment with oral doxycycline is satisfactory.201726996048
[bartonella henselae vertebral osteomyelitis: report of a case].cat scratch disease (csd) is caused by bartonella henselae, with unknown prevalence and incidence in the chilean paediatric population. regional lymphadenopathy is the most common presentation, while atypical forms constitute a diagnostic challenge.201726460082
full-thickness macular hole in bartonella henselae neuroretinitis in an 11-year-old girl.cat scratch disease is a febrile illness caused by bartonella henselae and is associated with rash at the site of cat bite or scratch and regional lymphadenopathy. various ocular manifestations of cat scratch disease have been described, mainly retinochoroiditis, optic disc swelling, neuroretinitis, vascular occlusive events, serous retinal detachment, vitreous hemorrhage, intermediate uveitis, inflammatory lesions of the optic nerve head and rarely full thickness macular hole. we describe a cas ...201725709274
neuroretinitis secondary to bartonella henselae in the emergent setting. 201725586979
analysis of seroreactivity against cell culture-derived bartonella spp. antigens in dogs.little is known about the specificity of bartonella spp. immunofluorescent antibody (ifa) assays in dogs. bacteremia in sick dogs most often has been associated with bartonella henselae (bh), bartonella vinsonii subspecies berkhoffii (bvb), and bartonella koehlerae (bk). clarification of the diagnostic utility of ifa serology when testing against these organisms is needed.201724341682
identification of bartonella henselae in the liver of a thoroughbred foal with severe suppurative cholangiohepatitis. 201724814868
macular hole following bartonella henselae neuroretinitis.to report a case of macular hole secondary to bartonella henselae neuroretinitis.201728221619
infection to pathogens with different transmission modes in feral cats from urban and rural areas of korea.in this study, we examine the prevalence of three infectious pathogens with different transmission modes (bartonella henselae, hemoplasma and toxoplasma gondii) in feral cats (felis catus) from two unique habitat types, urban and rural. we determined the infection status of three pathogens in blood samples (total n=117) through molecular or serological diagnostic methods. overall prevalence of hemoplasma, t. gondii and b. henselae was 47.9%, 50% and 35.7%, respectively. only seroprevalence of b. ...201728385003
molecular survey of bartonella henselae and bartonella clarridgeiae in pet cats across japan by species-specific nested-pcr.cats are known to be the main reservoir for bartonella henselae and bartonella clarridgeiae, which are the agents of 'cat-scratch disease' in humans. in the present study, we investigated the prevalence of the two bartonella species on 1754 cat bloods collected from all prefectures in japan during 2007-2008 by a nested-polymerase chain reaction (pcr) targeting the 16s-23s rrna internal transcribed spacer region. overall, bartonella dna was detected in 4·6% (80/1754) of the cats examined. the nes ...201728780918
[elbow abscess revealing cat-scratch disease: about a case].cat-scratch disease (csd) is a common cause of chronic benign lymphadenopathy in the child and the young adult. bartonella henselae is the agent responsible for this disease. common symptoms include regional lymphadenopathy associated with fever. we report a clinically atypical and potentially misleading case of a 18-year old girl with csd revealed by elbow abscess.201728819488
cat scratch disease: u.s. clinicians' experience and knowledge.cat scratch disease (csd) is a zoonotic infection caused primarily by the bacterium bartonella henselae. an estimated 12,000 outpatients and 500 inpatients are diagnosed with csd annually, yet little is known regarding clinician experience with and treatment of csd in the united states. questions assessing clinical burden, treatment and prevention of csd were posed to 3,011 primary care providers (family practitioners, internists, paediatricians and nurse practitioners) during 2014-2015 as part ...201728707827
bartonella henselae neuroretinitis associated with central retinal vein occlusion, choroidal ischemia, and ischemic optic neuropathy.we describe a healthy 37-year-old man with bartonella henselae (b. henselae) neuroretinitis with concurrent central retinal vein occlusion and ischemic optic neuropathy resulting in optic atrophy and choroidal ischemia.201728700390
comparative proteomic analysis of the outer membrane protein 43 (omp43) deficient bartonella henselae.outer membrane proteins (omps) of gram-negative bacteria constitute the first line of defense that protects the cells against environmental stresses including chemical, biophysical, and biological attacks. although 43-kda outer membrane protein (omp43) is major porin protein among the bartonella henselae-derived omps, its function remains unknown. in this study, omp43-deficient mutant b. henselae (δomp43) was generated to investigate function of omp43. interestingly, δomp43 showed a weaker proli ...201728693313
[cat scratch disease - a neglected zoonosis].cat scratch disease is a relatively rare infection that is caused by the bacterium bartonella henselae. this disease occurs after cat scratch or bite. the course of the disease depends on the patients immunity status. in immunocompetent patients, the disease typically runs as a lymph node syndrome. sometimes, mild general symptoms may appear, or the course can be atypical with a more serious clinical manifestation involving various organs. in immunocompromised patients, bartonella henselae can c ...201728691834
bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease.bartonella henselae, the agent of cat scratch disease (csd), appears to be a common organism responsible for lymphadenitis in both adults and children. there is a very low isolation rate for b. henselae from lymph nodes of patients with csd. our objective was to evaluate b. henselae viability in a large series of lymph nodes from patients with csd. from january to november 2016, we analyzed lymph node biopsy samples from patients diagnosed with csd. we used reverse transcription-quantitative pol ...201728669017
cat scratch disease: not a benign condition.describe a case series of ocular cat-scratch-disease (csd) with vision-threatening findings and poor outcomes, indicating severity of disease.201728665750
neurological and immunological dysfunction in two patients with bartonella henselae bacteremia.recently, bapgm enrichment culture has documented bartonella bacteremia in previously healthy, "nonimmunocompromised" patients following arthropod exposures. neurobartonellosis should be among the differential diagnoses for patients with persistent or recurrent neurological symptoms of undetermined etiology. microbiological and immunological testing should be concurrently pursued to determine whether defective immune function accompanies bartonella bacteremia.201728588842
beware the cat: bartonella henselae infections and biologic therapies. 201728532821
the seroprevalence of bartonella henselae in healthy adults in korea.cat-scratch disease (csd), caused by bartonella henselae is one of the most common zoonosis. however, only several cases of b. henselae infection have been reported in korea. this study investigated the seroprevalence of b. henselae in healthy adults and related risk factors.201728490714
prosthetic valve endocarditis caused by bartonella henselae presenting as recurrent fever and imitating granulomatosis with polyangiitis. 201728446372
the conjugative relaxase trwc promotes integration of foreign dna in the human genome.bacterial conjugation is a mechanism of horizontal dna transfer. the relaxase trwc of the conjugative plasmid r388 cleaves one strand of the transferred dna at the orit gene, covalently attaches to it, and leads the single-stranded dna (ssdna) into the recipient cell. in addition, trwc catalyzes site-specific integration of the transferred dna into its target sequence present in the genome of the recipient bacterium. here, we report the analysis of the efficiency and specificity of the integrase ...201728411218
multiorgan involvement confounding the diagnosis of bartonella henselae infective endocarditis in children with congenital heart disease.two children with congenital heart disease status post surgical correction presented with prolonged constitutional symptoms, hepatosplenomegaly and pancytopenia. concern for malignancy prompted bone marrow biopsies that were without evidence thereof. in case 1, echocardiography identified a multilobulated vegetation on the conduit valve. in case 2, transthoracic, transesophageal and intracardiac echocardiography were performed and were without evidence of cardiac vegetations; however, pulmonic e ...201728403058
acute unilateral vision loss in a female adolescent due to ocular bartonellosis.acute worsening of visual acuity with optic disc edema is commonly assumed to be due to idiopathic intracranial hypertension. bartonella henselae is an unusual cause to abrupt vision loss that is associated with optic disc edema and exudative macular stars seen on examination. it is an important cause to be aware of because it responds very well to antibiotic treatment. we present a case of a female adolescent with unilateral vision loss cause by cat-scratch neuroretinitis.201728398939
bartonella henselae as a cause of acute-onset febrile illness in cats.at different time points spanning 6 months, three adopted feral flea-infested cats, residing in the household of a veterinary technician, became acutely anorexic, lethargic and febrile. enrichment blood culture/pcr using bartonella alpha proteobacteria growth medium (bapgm) confirmed initial infection with the same bartonella henselae genotype in all three cases. with the exception of anemia and neutropenia, complete blood counts, serum biochemical profiles and urinalysis results were within ref ...201728491382
cat-scratch disease presenting as multiple hepatic lesions: case report and literature review.although infectious diseases are the most prevalent cause of fevers of unknown origin (fuo), this diagnosis remains challenging in some pediatric patients. imaging exams, such as computed tomography (ct) are frequently required during the diagnostic processes. the presence of multiple hypoattenuating scattered images throughout the liver associated with the history of cohabitation with cats should raise the suspicion of the diagnosis of cat-scratch disease (csd), although the main etiologic agen ...201728580326
seronegative cat-scratch disease diagnosed by pcr detection of bartonella henselae dna in lymph node samples.cat scratch disease (csd), the typical clinical manifestation of bartonella infections usually follows a typical benign self-limited course. nevertheless, a variety of unusual clinical manifestations and confusing imaging features can lead to misinterpretations and render the disease a diagnostic dispute. routine laboratory tests exhibit varying reported sensitivity and are usually unhelpful in diagnosis, as serology fails in terms of specificity and/or sensitivity. herein we report a case of se ...201722358366
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