Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| epidemiological evidence for causal relationship between epstein-barr virus and burkitt's lymphoma from ugandan prospective study. | results from a prospective sero-epidemiological study initiated in uganda in 1971 indicate that children with high antibody titres to epstein-barr virus structural antigens are at high risk of developing burkitt's lymphoma. these findings strongly support a causal relationship between the epstein-barr virus and burkitt's lymphoma but suggest that the oncogenic potential of the virus is realised only in exceptional circumstances. | 1978 | 210392 |
| binding to chromosomes of herpes simplex-related antigens in biochemically transformed cells. | association of herpes simplex virus (hsv)-related antigens with chromosomes was demonstrated in human and mouse cells biochemically transformed by hsv that had been irradiated with ultraviolet light. this was accomplished by using peroxidase-anti-peroxidase immunological staining with rabbit antisera that had high neutralizing titers against both hsv-specific thymidine kinase activity and virus infectivity. antisera-against hsv did not react with chromosomes of uninfected cells nor did normal se ... | 1978 | 210457 |
| studies on the association of the epstein-barr virus genome and human chromosomes. | we have used human-mouse somatic cell hybrid to study the association between the ebv genome and the cellular genome. attempts were made to identify a specific human chromosome(s) with which the ebv genome is associated. our data suggest that at least in the mouse fibroblast/burkitt lymphoma hybrid combination studies, the ebv genome is not associated with any specific human chromosome. | 1978 | 209053 |
| bone marrow-derived lymphoid cell lines from patients with agammaglobulinemia. | in vitro infection with epstein-barr virus of bone marrow-derived (b) lymphocytes from blood of patients with x-linked or common varied agammaglobulinemia resulted in the establishment of long-term b-lymphoid cell lines (lcl). lcl were established only with b lymphocytes from patients whose b cells failed to respond to in vitro mitogenic stimulation. in contrast, lymphocytes from patients without small b lymphocytes or with b cells that synthesized but failed to secrete ig failed uniformly to es ... | 1978 | 209061 |
| activation of endogenous type c virus in balb/c mouse cells by herpesvirus dna. | several virion and nonvirion dnas were tested for the ability to activate endogenous type c virus in balb/c-derived mouse cells using the calcium precipitation technique. the dnas from all herpesviruses tested activated xenotropic type c virus synthesis. these included dnas from herpes simplex virus types 1 and 2, epstein-barr virus, human cytomegalovirus, sa8 virus, infectious bovine rhinotracheitis virus, pseudorabies virus, and herpes saimiri virus (m-dna). in contrast, dnas from vaccinia vir ... | 1978 | 212761 |
| current assessment of "case clustering" of lymphomas and leukemias. | 1978 | 210923 | |
| [isolation of the epstein-barr virus in suspension cell lines obtained from persons with different forms of hemoblastosis]. | isolation of ebv from patients with different types of haemoblastosis by establishing virus-producing cell lines is described. ebv was isolated from patients with myelogenous leukemia in 71%, hodgkin's disease--in 22%. ebv was also isolated from 1 patient with lung tumor and leukemogenic reaction. all 8 established cell lines produced ebv in 0.5--3% of cells. the cells of the lines concerned are lymphoblasts and show b-cell characteristics. | 1978 | 212872 |
| latent viruses and bell's palsy in children. | 4 children with unilateral facial palsy--bell's palsy (bp)--had serological evidence of primary infection with epstein-barr virus (ebv). concomitant infection with cytomegalovirus (cmv) was demonstrated in 1 child while in all 4 children a rise in antibody titers to an additional one or two viruses was demonstrated. the viruses involved were herpes simplex, cmv and adenovirus which are latent in humans. immunosuppression induced by ebv and steroid treatment may cause reactivation of these viruse ... | 1978 | 213283 |
| serological reactivities of human and baboon sera against ebna and herpesvirus papio-determined nuclear antigen (hupna). | 1978 | 213288 | |
| host cell reactivation of epstein-barr virus in normal and repair-defective leukocytes. | 1978 | 210932 | |
| electron microscopic studies of tumor viruses. ii. entry and uncoating of epstein-barr virus. | entry of epstein-barr virus into human lymphoblastoid cells (daudi cells) was studied by electron microscopy. at the site of viral attachment, two distinct interactions conducive to penetration of the virus occurred between the viral envelope and cell membrane, namely, (i) simultaneous dissolution of both the envelope and cell membrane, presumably resulting in passage of viral capsids into the cytoplasm and (ii) dissolution confined to the cell membrane with resulting penetration of enveloped vi ... | 1978 | 214669 |
| epstein-barr virus early antigen titer by immunofluorescence in microplates. a new semi-automated method based on microtiter system. | for the titration of antibodies directed against epstein-barr virus early antigen (ebv-ea) we describe a method in microplates with the microtiter system (cooke engineering co., alexandria, va). using this technique, which allows rapid epidemiological investigations, we have titered anti-ebv-ea antibodies in different groups of patients and controls, and particularly in group which had recent contact with infectious mononucleosis. in this group the percentage of individuals having antibodies dir ... | 1978 | 214682 |
| complete heart block in epstein-barr myocarditis. | 1978 | 214746 | |
| detection of epstein-barr virus antigens and antibodies by peroxidase-labeled specific immunoglobulins. | detection of the epstein-barr (ebv) antigens, early antigen (ea), viral capsid antigen (vca), and nuclear antigen (ebna) by the indirect immunoperoxidase technique was highly sensitive. antibody titers to ebna, ea, and vca were determined in more than 25 sera of patients with burkitt lymphoma (bl), nasopharyngeal carcinoma (npc), or normal persons. a good correlation between the titers of these antigens was obtained by the immunoperoxidase and immunofluorescence methods. the indirect (anti-igg) ... | 1978 | 212523 |
| purification of the epstein-barr virus-determined nuclear antigen from epstein-barr virus-transformed human lymphoid cell lines. | the epstein-barr virus-determined nuclear antigen (ebna) was purified from extracts of the human lymphoid cell lines raji, namalwa, and b95-8/mld by two different methods. in the first approach, the apparently native antigen was purified 1,200-fold by a four-step procedure involving dna-cellulose chromatography, blue dexptran-agarose chromatography, hydroxyapatite chromatography, and gel filtration, employing complement fixation as the assay procedure. such ebna preparations specifically inhibit ... | 1978 | 212583 |
| chromosomal association of an epstein-barr virus-associated nuclear antigen. | 1978 | 212669 | |
| prospects of vaccines against cancer in man. | preventive immunization is the cheapest and most effective approach to the management of epidemic disease. certain forms of cancer, including burkitt's lymphoma, carcinoma of the cervix, primary liver cancer, acute leukaemia and breast cancer show many characteristics of epidemic disease, and the possibility of producing preventive vaccine against these conditions merits serious consideration. | 1978 | 212839 |
| insulin inhibits cellular and herpes simplex virus dna synthesis in transformed lymphoblastoid cell lines. | treatment of uninfected and herpes simplex virus-infected lymphoblastoid cells with 4 units of insulin per milliliter resulted in the inhibition of both cellular and viral dna synthesis. | 1978 | 213399 |
| two epstein-barr virus-associated dna polymerase activities. | we have partially purified and characterized two separate dna polymerase activities associated with epstein-barr virus (eb virus). one activity is present in eb virus producer cell lines but not in nonproducer or negative cell lines. it adheres more strongly to deae-cellulose than any host cell enzymes, eluting at 210 to 270 mm potassium phosphate buffer. further elution from phosphocellulose and sedimentation in glycerol gradients yields an enzyme purified 900-fold with an s value of 8.3. the s ... | 1978 | 213439 |
| epstein-barr virus in somatic cell hybrids between mouse cells and human nasopharyngeal carcinoma cells. | somatic cell hybrids between mouse cells and cells derived directly from npc biopsies were produced in order to study the association of the epstein-barr virus (ebv) genome and the expression of epstein-barr nuclear antigen (ebna) with the human chromosome(s). all attempts to correlate the presence of ebv-dna and the expression of ebna with the presence of a particular human chromosome(s) showed that the segregation of ebv-dna or of ebna and human chromosomes was dysconcordant. the data, therefo ... | 1978 | 213442 |
| intracisternal tubular inclusions in nasopharyngeal carcinoma. | biopsy specimens obtained from 20 cases of nasopharyngeal carcinoma were examined under electronmicroscope for the presence of intracisternal tubular inclusions (iti). in eight (40 per cent) of them these inclusions could be identified. although the morphogenesis and significance of these iti are not clearly understood, they have been found in several autoimmune and viral diseases, including infectious mononucleosis, a disease caused by ebv, and burkitt's lymphoma, which is closely associated wi ... | 1978 | 213517 |
| screening of anti-b cell antibodies in the sera of renal transplant recipients by using daudi cell line. | in order to examine the presence of antibodies against b cells, 83 sera obtained from 55 renal transplant recipients were screened by microcytotoxicity test using daudi cell line. out of 83 samples, 12 were pretransplant sera, 62 were post-transplant sera and 9 were from the patients whose grafts has been removed due to rejection. for the purpose of improving the reliability of the tests, 5 different rabbit complements were selected and cytotoxicity tests with them were carried out simultaneousl ... | 1978 | 213630 |
| interaction of the b95-8 and p3hr-1 substrains of epstein-barr virus (ebv) with peripheral human lymphocytes. | two substrains of the epstein-barr virus derived from the b95-8 and p3hr-1 cell lines were studied for their interaction with human peripheral lymphocytes. it has been previously shown that b95-8 virus has and p3hr-1 virus lacks lymphocyte-transforming ("immortalizing") properties. dna stimulation induced by b95-8 virus showed a good correlation with the number of surface ig-positive cells. p3hr-1 virus added before b95-8 virus completely abolished the stimulation of dna synthesis. it also preve ... | 1978 | 212371 |
| presence of ebna in nasopharyngeal carcinoma and control patient tissues related to ebv serology. | 1978 | 212372 | |
| [virus diseases of the lymphatic system. differential diagnosis and therapy]. | 1978 | 212661 | |
| [complex antibody studies in suspected infectious mononucleosis]. | 1978 | 212703 | |
| expression of latent epstein-barr virus genomes in human epithelial/burkitt's lymphoblastoid hybrid cells. | expression of latent epstein-barr virus genomes in somatic-cell hybrids of burkitt's lymphoblastoid cells has been studied. treatment of the hybrid cells, d98/raji and d98/hr-1, with iudr induced the formation of ea and vca and replication of virus dna, whereas the same treatment of raji cells induced only the formation of ea. the patterns of transcription of virus genomes in these three cell lines were, however, very similar: 25% without treatment with iudr, 30% immediately after the treatment ... | 1978 | 215523 |
| interaction between epstein-barr virus and type-c virus in human cells. | the interaction between ebv and type-c viruses was studied in our fvnc experimental system, in which ebv and type-c viral genomes are contained in each cell. the data indicate that the human lymphoid fvnc cells are sensitive to both ebv and type-c virus exposure, showing high frequencies of induction of both repressed viral genomes. the two different viral genomes may be associated with different chromosomes in individual cells. | 1978 | 215524 |
| epstein-barr virus-related serology in nasopharyngeal carcinoma and controls. | 1978 | 215525 | |
| clinical evaluation of ebv serology in american patients with nasopharyngeal carcinoma. | there is now extensive immunological, biological and biochemical evidence to support a possible etiological relationship between ebv and npc in patients from different geographical locations. besides providing information on the question of etiology, the results from immunological investigations suggest that antibodies to some of the ebv-associated antigens might also be of clinical importance in the diagnosis and prognosis of npc. to determine the possible clinical application of ebv serology t ... | 1978 | 215526 |
| the genetic and antigenic basis for the iga antibody response to epstein-barr viral capsid antigen. | 1978 | 215527 | |
| presence of epstein-barr virus specific iga in saliva of nasopharyngeal carcinoma patients: their activity, origin and possible clinical value. | 1978 | 215528 | |
| isolation of a herpesvirus-specific dna polymerase from tissues of an american patient with burkitt lymphoma. | a dna polymerase (dna nucleotidyltransferase) has been partially purified from a neck mass of an american patient with burkitt lymphoma and separated from the cellular dna polymerases. the molecular weight of the enzyme was approximately 90,000. the enzyme differs from the cellular dna polymerases, but resembles herpes-virus-induced dna polymerase in its primer template preference, high monovalent cation requirement for activity, and sensitivity to phosphonoacetate. enzyme activity was inhibited ... | 1978 | 212756 |
| lysosomal acid hydrolases in established lymphoblastoid cell lines, transformed by epstein-barr virus, from patients with genetic lysosomal storage diseases. | lysosomal acid hydrolases were determined in established lymphoblastoid cell lines, transformed in vitro by epstein-barr virus (ebv) from lymphocyte-rich cell populations isolated from the peripheral blood of patients with genetic lysosomal storage diseases--hurler syndrome, scheie syndrome, gm1-gangliosidosis type 1 and type 2, tay-sachs disease, and i-cell disease--and from obligate heterozygotes for these diseases. the respective enzyme activity was undectectable in lymphoblastoid cells from ... | 1978 | 213379 |
| [an autopsy case of acute myeloblastic leukemia with persistent high anti ebv-antibody titer (author's transl)]. | 1978 | 213625 | |
| epstein-barr virus-regulation studies on somatic-cell hybrids derived from the fusion of burkitt's lymphoma and nasopharyngeal carcinoma cells with human or mouse partners. | 1978 | 215519 | |
| detection of b-lymphocyte (b-cell)-associated antigens on human leukemic lymphocytes. masking of membrane antigens. | an indirect immunofluorescent technic has been used for rabbit antisera (anti-ep) that demonstrated complement-dependent cytotoxicity against human leukemic lymphocytes but not against normal blood lymphocytes. with the immunofluorescent technic, the antisera were found to react with 2--23% of normal blood lymphocytes. simultaneous staining of normal cells with anti-ep and for surface immunoglobulins (sig) on bone-marrow-derived b-cells showed that the proportions of stained cells were similar t ... | 1978 | 213964 |
| stimulation of human peripheral blood lymphocytes by autologous ebv-infected b cells. | 1978 | 214248 | |
| dna of epstein-barr virus. iv. linkage map of restriction enzyme fragments of the b95-8 and w91 strains of epstein-barr virus. | the arrangement of ecori, hsu i, and sal i restriction enzyme sites in the dna of the b95-8 and w91 isolates of epstein-barr virus (ebv) has been determined from the size of the single-enzyme-cleaved fragments and from blot hybridizations that identify which fragments cut from the dna with one enzyme contain nucleotide sequences in common with fragments cut from the dna with a second enzyme. the dna of the b95-8 isolate was the prototype for this study. the data indicate that (i) approximately ... | 1978 | 214576 |
| antigenic content of an in vitro cellular immunity reactive cell surface extract of raji cells. | antigenic content of a raji cell surface extract (ts) was studied by sequential abosrption of rabbit antiserum to this extract with different cells. anti-ts was first allowed to react exhaustively with human blood cells followed by hela cells and human diploid fibroblasts. the residual reactivity was studied by stepwise absorption with an ebv-negative b lymphoblastoid cell line, bjab, and then with b1--19, a clone derived from ebv transformed bjab cells. these processes delineated three kinds of ... | 1978 | 215106 |
| expression of altered ribonucleotide reductase activity associated with the replication of the epstein-barr virus. | 1978 | 210572 | |
| sensitization of lymphocytes against pooled allogeneic cells. i. generation of cytotoxicity against autologous human lymphoblastoid cell lines. | lymphocytes sensitized in vitro to a pool of x-irradiated allogeneic normal lymphocytes from 20 individuals develop cytotoxic activity for autologous human lymphoblastoid cells (lcl). whereas pool sensitized t lymphocytes lyse autologous lcl cells, they fail to lyse autologous b-enriched or t-enriched normal target cells nor autologous phytohemagglutinin (pha) blasts. in contrast to pool sensitization, stimulation with normal cells of single allogeneic individuals rarely led to development of cy ... | 1978 | 206649 |
| epstein-barr virus is not synonymous with infectious mononucleosis. | 1978 | 205830 | |
| a greatly simplified method of establishing b-lymphoblastoid cell lines. | ten lymphoblastoid cell lines were established by epstein-barr virus-induced transformation directly from 0.04 to 0.15 ml of peripheral whole blood of one patient with xeroderma pigmentosum and four normal healthy adults. all these lines expressed b-lymphocyte characteristics. the advantages of this method are: (a) only a few drops of blood are required for establishing a permanent line; (b) damage and loss of cells in separation procedures are minimal; and (c) the method is simple, reliable, an ... | 1978 | 210942 |
| autoradiographic detection of epstein-barr virus (ebv)-associated early antigen in a variety of ebv dna-containing lymphoblastoid cell lines previously designated as nonproducers. | by using autoradiography combined with 125i-labeled igg prepared from human sera containing high anti-ea (early antigen) antibody titers, ea has been detected in a low fraction of cells in a variety of ebv dna-containing cell lines previously designated as negative for this antigen. these positive cell lines are highly inducible for ea following treatment with iododeoxyuridine (iudr) and also contain multiple copies of the virus genome on average. the correlation between iudr inducibility and sp ... | 1978 | 204604 |
| transforming activity of epstein-barr virus obtained by superinfection of raji cells. | epstein-barr virus obtained by superinfection of raji cells with epstein-barr virus recovered from p3hr1 cells (hri virus) transformed human lymphocytes, but it did not superinfect raji cells. a human lymphoblastoid cell line, hlb, established by such transformation contained 22 epstein-barr virus genomes per cell and epstein-barr virus-associated nuclear antigen, and a few cells contained early or viral capsid antigen complexes. chromosomal analysis revealed that hlb-cells were diploid with nor ... | 1978 | 205877 |
| genetics of neoplasia--impact of ecogenetics on oncogenesis. a review. | 1978 | 207190 | |
| a new manifestation of infection with epstein-barr virus. | 1978 | 209846 | |
| activation of the alternative complement pathway by human b cell lymphoma lines is associated with epstein-barr virus transformation of the cells. | activation of the alternative complement pathway by human b cell lymphoma lines is correlated with the presence of epstein barr virus (ebv) in the cell genome. ebv-negative b cell lymphoma lines produce little activation of the alternative pathway as measured either by c3 deposition on the cell surface or c3 conversion and consumption of alternative pathway activity in the supernatant serum. by contrast, ebv-positive sublines derived by in vitro ebv conversion of ebv-negative parental lines prod ... | 1978 | 211040 |
| sensitivity of the transforming and replicative functions of epstein--barr virus to inhibition by phosphonoacetate. | disodium, phosphonoacetate (pa), at concentrations of 50 to 200 microgram/ml, which still allowed continued growth of the eb virus-transformed b95-8 cell line on a routine culture regimen, was able to inhibit the production of virus capsid antigen and of virus particles by these cells down to very low but finite levels which persisted despite prolonged treatment. further experiments measured the effects of these same drug concentrations on the eb virus-induced in vitro transformation of foetal c ... | 1978 | 211188 |
| improved detection of virus-specific igm antibodies. elimination of non-specific igm binding. | a non-specific reaction between human igm and cytoplasmic structures of virus infected cells can often be observed if mgm antibodies to virus antigens are detected by indirect immunofluorescence or by immuno enzyme assays. formaldehyde selectively inactivates the cytoplasmic receptors for human igm without affecting the virus structural proteins. alternatively, receptor-free antigens can be obtained by isolation of nuclei from virus infected cells. due to reduced background, a more specific and ... | 1978 | 211190 |
| studies of epstein-barr virus (ebv)-associated nuclear antigen: solubilization from raji cell chromatin with 5 m-urea-2 m-nacl and fractionation on hydroxyapatite. | ebna-containing chromatin from raji cells was solubilized by treatment with high concentrations of urea and salt and fractionated by hydroxyapatite chromatography. fractions eluting at different phosphate concentrations were analysed for the presence of ebna by means of an anti-ebna-specific 125i-labelled igg absorption assay. the antigen was found in fractions containing non-histone chromatin proteins. | 1978 | 211194 |
| persistence of both human cytomegalovirus and epstein-barr virus genomes in two human lymphoblastoid cell lines. | by dna-dna reassociation kinetic analysis, less than one genome equivalent per cell of human cmv-dna was found in two lymphoblastoid cell lines, one derived from the peripheral blood of a congenitally infected male infant at the age of 21 months (d4 cell line), the other obtained by co-cultivation of lethally x-irradiated cells from the 9-month lymphoblastoid cell line previously described by joncas et al. (1975) with cord blood leukocytes of a female newborn (m1 cell line). human cmv antigens c ... | 1978 | 211195 |
| heterogeneity of epstein-barr virus. iii. comparison of a transforming and a nontransforming virus by partial denaturation mapping of their dnas. | the dnas of a transforming and a nontransforming epstein-barr virus strain, b95-8 and p3hr-1, were compared by partial denturation mapping. b95-8 viral dna showed a homogeneous denaturation pattern. in contrast, p3hr-1 viral dna was heterogeneous, containing at least two classes of molecules, classified into groups a and b and present in a ratio of about 2:1 to 3:1. no evidence could be obtained that molecules from both groups a and b contain identical sequences present in different orientations ... | 1978 | 211256 |
| dna of epstein-barr virus. iii. identification of restriction enzyme fragments that contain dna sequences which differ among strains of epstein-barr virus. | previous kinetic and absorption hybridization experiments had demonstrated that the dna of the b95-8 strain of epstein-barr virus was missing approximately 10% of the dna sequences present in the dna of the hr-1 strain (r.f. pritchett, s.d. hayward, and e. kieff, j. virol. 15:556-569, 1975; b. sugder, w.c. summers, and g. klein, j. virol. 18:765-775, 1976). the hr-1 strain differs from other laboratory strains, including the b95-8 and w91 strains, and from virus present in throat washings from p ... | 1978 | 211267 |
| [hodgkin's disease: effect of spenectomy on the immune status (author's transl)]. | in 22 untreated hodgkin's patients the following parameters were studied before and after splenectomy: the total wbc, lymphocytes, b- and t-cells and mitogenic stimulation of peripheral lymphocytes using autologous and control serum. the results were correlated to patient groups with favourable and unfavourable prognosis according to pathological stage, histology, spleen involvement and constitutional symptoms. 1. all patients. significant increase of the absolute number of peripheral lymphocyte ... | 1978 | 211317 |
| shedding of anti-igm from antibody-coated human lymphoma lines: differences between epstein-barr virus-negative lines and their virus-converted sublines. | in vitro converted, epstein-barr (ebv) genome-carrying cell lines showed a reduced ability to shed surface-bound antibodies, compared to their ebv-free parental b lymphoma lines. on the other hand, antibody degradation was higher with ebv-positive cells. analysis of antibody-coated single cells revealed that cells which failed to redistribute or cap their ligand-bound surface components at 37 degrees c, were also capable of shedding bound antibody. this suggests that capping and shedding are ess ... | 1978 | 207534 |
| [[auto] critique of a tumor virology (author's transl)]. | 1978 | 211545 | |
| [incidence and specificity of circulating immune complexes in infectious mononucleosis (proceedings)]. | occurrence of immune complexes in infectious mononucleosis has been investigated by the 125i clq binding assay. increased serum clq-binding activity was found in 87% of the 23 patients studied during the acute stage of the disease. the serum clq-binding material detected has properties identical to those of immune complexes. igg antibodies dissociated from the complexes at acid ph and f (ab)'2 fragments obtained after treatment by pepsin appeared to be directed against the viral capsid antigen o ... | 1978 | 211580 |
| [sero-epidemiologic studies of epstein-barr virus in israel]. | 1978 | 207624 | |
| human malignant lymphomas in vitro. characterization of biopsy cells and establishment of permanent cell lines. | a series of 55 biopsies from different types of malignant lymphomas were characterized in short-term culture experiments and during prolonged growth in vitro. the majority of the lymphocytic lymphomas and half of the histiocytic lymphomas expressed surface immunoglobulin, either in monoclonal or polyclonal form, indicating b-lymphocyte derivation. no lysozyme production was noted in either type of lymphoma, giving further support to the notion that histiocytic lymphomas are not truly histiocytic ... | 1978 | 211794 |
| cultural, morphological, cell membrane, enzymatic, and neoplastic properties of cell lines derived from a hodgkin's disease lymph node. | a neoplastic cell line (designated hut11) has been established in continuous culture from an involved lymph node of a patient with stage iia hodgkin's disease of the mixed cellularity type. the hut11 line has been morphologically heterogeneous, consisting of mononucleate lymphoid-like cells, polygonal epithelioid cells, and mono-, bi-, and multinucleate giant cells. four clones initiated from isolated binucleate giant cells of the hut11 line also have been successfully established as continuous ... | 1978 | 209894 |
| detection of epstein-barr virus (ebv) dna sequences using in situ hybridization. | in situ hybridization was used to detect epstein-barr virus (ebv) dna sequences under conditions where the virus dna is replicating spontaneously and where it is induced to do so following superinfection. the in situ reaction itself is influenced by several parameters, analogous to conventional nucleic acid hybridization, consideration of which should help to optimize the designing of in situ hybridization reactions in general. both ebv complementary rna (crna) and ebv dna synthesized in vitro c ... | 1978 | 208612 |
| detection of epstein-barr virus in biopsied malignant lymphoma cell and its continuous culture. | in more than 80% of tumor cells in the pericardiac effusion of a case of malignant b-cell lymphoma, epstein-barr virus-determined nuclear antigen (ebna) was detected by the anticomplement immunofluorescence test. moreover, herpestype virus particles, although few in number, were demonstrated in the nucleus of lymphoma cells by an electron microscope. tumor cells in the pericardiac effusion were seeded at 98% purity after centrifugation on ficoll-conray and, soon after plating, they proliferated ... | 1978 | 210075 |
| antigen-inducing ability of herpesvirus papio in human and baboon lymphoma lines, compared to epstein-barr virus. | herpesvirus papio(hvp)-carrying baboon lymphoblastoid lines do not express a nuclear antigen like the epstein-barr virus(ebv)-determined nuclear antigen (ebna), as judged by in situ anticomplement fluorescence staining, although the carry multiple viral genomes and, in the case of producerlines, early antigen (ea) and viral capsid antigen (vca) that cross-react with the corresponding human ebv-determined antigens. to test whether the lack of in situ nuclear antigen expression is a property innat ... | 1978 | 210135 |
| production of migration inhibitory factor (mif) by human leukocytes following exposure to epstein-barr virus. | 1978 | 208782 | |
| stimulation of peripheral human lymphocytes by autologous ebv genome-carrying lymphoblastoid cell lines. | 1978 | 208783 | |
| the detection of epstein barr virus antibody in 'exanthematic' dermatoses with special reference to pityriasis lichenoides. a preliminary survey. | 1978 | 206394 | |
| lymphoblastoid cell lines from sarcoid patients. | 1978 | 206399 | |
| appearance of early and late components of epstein-barr virus-associated membrane antigen in daudi cells superinfected with p3hr-1 virus. | this study investigated the synthesis of membrane antigen (ma) as well as virus capsid antigen (vca) and early antigen (ea) in daudi cells which had been superinfected with the p3hr-1 strain of epstein-barr virus (ebv) and then treated with trypsin to remove initially absorbed ma-positive material from the cell surface. synthesis of ma, vca and ea was completely inhibited by puromycin. a marked reduction in the frequency of ma positive cells was observed in superinfected cells cultured in the pr ... | 1978 | 202665 |
| lymphocytes transformed by epstein-barr virus. induction of nuclear antigen reactive with antibody in rheumatoid arthritis. | sera from approximately two-thirds of patients with rheumatoid arthritis contain an antibody which is reactive with a nuclear antigen present in human b-lymphocyte tissue culture cells. the immunological reaction can be demonstrated by precipitation and immunofluorescence. evidence is present that the reactive nuclear antigen is associated with epstein-barr (eb) virus-transformed lymphocytes. normal human peripheral blood lymphocytes did not contain the nuclear antigen reactive with rheumatoid a ... | 1978 | 206643 |
| epstein-barr (eb) virus genome-containing, eb nuclear antigen-negative b-lymphocyte populations in blood in acute infectious mononucleosis. | experiments have been performed to identify the type and size of cell infected by eb virus in the blood of acute infectious mononucleosis (im) patients, and to investigate the nature of the infection. virus-infected cells, recognized by their ability to give rise to lymphoblastoid cell lines when co-cultivated with foetal lymphocytes, were shown to be restricted to the b-lymphocyte population. samples of this population from each of eight im patients were found to be negative for eb nuclear anti ... | 1978 | 204732 |
| expression of an antigen associated with acute lymphoblastic leukemia in human leukemia-lymphoma cell lines. | 1978 | 206705 | |
| epstein-barr virus-associated thymidine kinase. | superinfection of raji cells with epstein-barr virus induced a new thymidine kinase that was distinguishable from both adult and fetal kinases of the host cell by discontinuous electrophoresis on polyacrylamide gels and glycerol gradients. | 1978 | 206728 |
| epstein-barr virus (ebv) receptors, complement receptors, and ebv infectibility of different lymphocyte fractions of human peripheral blood. ii. epstein-barr virus studies. | 1978 | 202404 | |
| posttransplantation syndrome in children: cytomegalovirus vs epstein-barr virus. | 1978 | 206131 | |
| an immunologic basis for detection of occult primary malignancies of the head and neck. | after extensive evaluation of patients with metastatic neck disease and clinically undetectable primary cancer of the head and neck, the clinician is often faced with the difficult question of subsequent management. in this study, sera from 11 patients with clinically occult carcinoma and metastatic lymphadenopathy were studied for epstein-barr virus-associated antigens. these were compared with 35 sera from patients with known nasopharyngeal carcinoma at all stages of disease and treatment and ... | 1978 | 205337 |
| ocular granulocytic sarcoma (chloroma) with acute myelomonocytic leukemia in turkish children. | in a series of 166 leukemic children from turkey, 56 had acute myelomonocytic leukemia (amml). seventeen boys and 3 girls presented with chloroma-like deposits (granulocytic or myeloid sarcomas) in the eye and orbit, all showing amml on initial study of blood and marrow. the ocular lesions responded rapidly to antileukemic therapy. laboratory studies of amml cases revealed no cytogenetic or immune defects, and epstein-barr virus titers were normal. a group-specific (gs-3) antigen (type-c virus?) ... | 1978 | 205341 |
| immune function in healthy relatives of patients with malignant disease. | immune function studies of healthy members of families with multiple lymphoreticular neoplasms were compared with those of healthy members of families with multiple cancers and families with no known history of cancer. the lymphoma family group had a significantly elevated serum level of igm and diminished responses to the candida albicans skin test antigen and the t-cell mitogen concanavalin a. subjects with epstein-barr virus-viral capsid antigen titers greater than or equal to 160 had lower r ... | 1978 | 203705 |
| a convenient method of establishing permanent lines of xeroderma pigmentosum cells. | nine lymphoblastoid cell lines were established after transformation by epstein-barr virus of peripheral lymphocytes from four xeroderma pigmentosum (xp) patients, the parents of one xp patient, and three normal donors. all these cell lines proliferate as suspension in roswell park memorial institute medium 1640 supplemented with 20% fetal bovine serum, without detectable release of infectious epstein-barr virus. some characteristics of these cell lines, such as growth rates, chromosome numbers, ... | 1978 | 202381 |
| [hepatology and immunology]. | immunologic diseases of the liver are exogenous mostly initiated by virus or endogenous initiated by autoaggression. all virus-induced kinds of hepatitis are due to an immune response against inocculated hepatocytes. therefore the hepatitis is limited to the period of complete elimination of virus-infected cells. a strong immune response therefore corresponds with an acute and short hepatitis whilest a weak immune response develops a chronic hepatitis. in contrast, autoimmune hepatitis based on ... | 1978 | 205495 |
| heterophil antigen in bovine sera detectable by immune adherence hemagglutination with infectious mononucleosis sera. | bovine sera for tissue culture use were shown to contain heterophil antigen of the paul-bunnell-davidsohn type by immune adherence hemagglutination tests with sera from patients with infectious mononucleosis. the antibody titers observed were comparable to those determined by two other methods; i.e., the immune adherence hemagglutination test was found to be as specific as the differential absorption test with horse erythrocytes or the ox cell hemolysis assay,but it appeared to be the most sensi ... | 1978 | 205510 |
| properties of epstein-barr virus transformed woolly monkey lymphoblastoid cell lines. | 1978 | 204945 | |
| an assessment of the possible role of viruses in the aetiology of burkitt's lymphoma. | 1978 | 205908 | |
| [infectious mononucleosis. 6. infectious mononucleosis with thrombocytopenia]. | 1978 | 205051 | |
| two e-rosette-forming lymphoid cell lines. | two e-rosette (spontaneous rosette with sheep red blood cells)-forming lymphoid cell lines were established. one (hpb-all) was derived from a young male japanese patient with acute lymphoblastic leukemia (all), and the other (hpb-mlt) was from a 62-year-old female japanese patient with a leukemic t-lymphoid malignancy. formation of e rosettes, absence of any immunoglobulin determinants, absence of ebna (epstein-barr virus associated nuclear antigen) and very limited stimulating ability in mixed ... | 1978 | 203546 |
| relationship between epstein-barr virus (ebv)-production and the loss of the ebv receptor/complement receptor complex in a series of sublines derived from the same original burkitt's lymphoma. | virus production, ebv (p3hr-1 substrain) superinfectability, idurd inducibility, ebv receptor and complement (c3) receptor expression were assessed in two independently maintained jijoye lines, the derived p3hr-1 clone that releases a growth inhibitory and cytopathic, non-transforming viral mutant, and in non-producer sublines derived from the p3hr-1 line by the spontaneous cessation of virus production. both jijoye lines were superinfectable, inducible, and carried ebv and c3 receptors. virus-p ... | 1978 | 207646 |
| demonstration of a surface antigen on epstein-barr virus genome-carrying lymphoid cells: distinction from the virus-determined membrane antigen. | a surface antigen (sa) was detected on epstein-barr virus (ebv)-carrying lymphoid cell lines by indirect membrane immunofluorescence with an antiserum from a rabbit immunized with raji cells; the antiserum had been extensively absorbed with normal human blood and tonsil cells. the sa was not detected on normal human umbilical cord and adult peripheral blood lymphocytes or ebv-negative cell lines. incidences of the sa and ebv-determined membrane antigen (ma) on certain ebv-carrying cell lines wer ... | 1978 | 207776 |
| reversible inhibition by phosphonoacetic acid of human b lymphocyte transformation by epstein-barr virus. | 1978 | 208257 | |
| mechanisms of infection with epstein-barr virus. iii. the synthesis of proteins in superinfected raji cells. | 1978 | 208266 | |
| factors affecting serum iga antibody to epstein-barr viral capsid antigens in nasopharyngeal carcinoma. | irrespective of the ethnic origin of the patient, nasopharyngeal carcinoma (npc), appears to stimulate the production of iga antibodies against vca. these antibodies are detected at high frequency and titres in sera from npc patients but only rarely from control subjects. a majority of relapse-free survivors tested 1-12 years after radiotherapy (rt) sustain a detectable level of iga anti-vca. serum titres of iga anti-vca remain relatively unchaged in individual npc patients after rt, regardless ... | 1978 | 205232 |
| epstein-barr virus. is it timely to discuss a vaccine? | 1978 | 208671 | |
| the epstein-barr virus (ebv) in human pathology. ii. serologic profiles of ebv infections. | antibodies to ebv induced intracellular antigens, (vca, ea, na) and vca-igm antibodies have been investigated to define ebv serologic profile of 245 individuals. this profile was a first studied in ebv primary infections. in infectious mononucleosis, the efficiency of ebv serodiagnosis is lower than paul bunnel davidsohn reaction (pbd) : primary infection profile is only characterised in 80% of the positive pbd infectious mononucleosis (im). on the other hand, ebv antibodies are preponderant for ... | 1978 | 208675 |
| experimental infection of callithrix jacchus marmosets with herpesvirus ateles, herpesvirus saimiri, and epstein barr virus. | we inoculated common marmosets (callithrix jacchus) with herpesvirus ateles (hva), herpesvirus saimiri (hvs), and epstein-barr virus (ebv). hva-induced tumors contained several cell types, including giant cells reminiscent of the sternberg-reed cells observed in human hodgkin's disease. hvs and ebv did not induce tumors, although hvs was present in lymphocytes and elicited a strong antibody response. ebv elicited only a variable antibody response. we feel that more common marmosets should be use ... | 1978 | 208678 |
| human studies following models of tumorigenesis by dna tumor viruses in animals. | the discovery of virus-specific messenger rna in virus-induced animal tumors has led to the search for messenger rna in human tumors that can be hybridized with the dna of known oncogenic viruses. attention has focused on the adenoviruses, which have produced cancer in laboratory animals and are widespread in man, and on three papovaviruses that have been isolated in human disease and which are oncogenic in hamsters. in other research, the association between human infection with herpesivurs typ ... | 1978 | 208690 |
| characterization of a unique cell line (laz 221) from human acute lymphocytic ("null" cell) leukemia. | a unique human cell line designated laz 221 has been established from the peripheral blood of a patient with acute lymphocytic leukemia of the "null" cell type. the cell line does not possess the epstein-barr virus nuclear antigen and has a karyotype of 45,xx,-9,-12,+(9q12q). both the established cell line and the patient's uncultured blast cells share the same phenotypic markers. they both lack t-cell markers. they fail to form sheep erythrocyte rosettes and do not react with t-cell-specific an ... | 1978 | 205365 |
| epstein-barr virus-determined nuclear antigen in malignant epithelial cells of nasopharyngeal carcinoma. | tumor tissue from lymph node metastasis of nasopharyngeal carcinoma (npc) was successfully heterotransplanted into an athymic nude mouse and the tumor grown in the nude mouse was identical in its morphology to that form the patient by optical and electron microscopy. tumor cells at passage 2 were dispersed in vitro by enzymic digestion and smeared. epstein-barr virus-determined nuclear antigen (ebna) was demonstrated in malignant epithelial cells of the smear. | 1978 | 205477 |
| gut lymphoma presenting simultaneously in two siblings. | 1978 | 202368 | |
| studies on cytotoxicity generated in human mixed lymphocyte cultures. i. time course and target spectrum of several distinct concomitant cytotoxic activities. | 1978 | 205612 | |
| a new tumour-derived transforming strain of epstein-barr virus. | 1978 | 205793 |